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172
resultados
Última actualización
03/04/2026 [07:19:00]
Resumen de: AU2024327179A1
In this specification, a new design and formulation of an expandable dosage form is presented where the post-expansion mechanical properties and the drug release rate by the dosage form can be independently controlled. The dosage form generally comprises a fluid-absorptive, expandable solid core, a mechanically strengthening semi-permeable layer substantially encapsulating said fluid-absorptive core, and a drug-containing solid applied outside said encapsulated core.
Resumen de: AU2024327475A1
In this specification, a new design and formulation of an expandable, gastroretentive dosage form is presented where the post-expansion mechanical properties and the drug release rate can be independently controlled. The dosage form generally comprises a drug-laden formulation attached to an expandable, gastroretentive solid.
Resumen de: AU2026202035A1
Abstract The invention provides an implant for covering a thorax bone defect, comprising: 5 at least one lattice structure of individual lattice cells, each lattice cell comprising one or more ring elements, each ring element comprising a through-hole configured for receiving a fixation device, at least some of the ring elements of each lattice structure 10 being connected via non-linear bridge elements to one another, wherein the implant is made at least predominantly from a plastic material. ar b s t r a c t a r h e i n v e n t i o n p r o v i d e s a n i m p l a n t f o r c o v e r i n g a t h o r a x b o n e d e f e c t , c o m p r i s i n g : a t l e a s t o n e l a t t i c e s t r u c t u r e o f i n d i v i d u a l l a t t i c e c e l l s , e a c h l a t t i c e c e l l c o m p r i s i n g o n e o r m o r e r i n g e l e m e n t s , e a c h r i n g e l e m e n t c o m p r i s i n g a t h r o u g h - h o l e c o n f i g u r e d f o r r e c e i v i n g a f i x a t i o n d e v i c e , a t l e a s t s o m e o f t h e r i n g e l e m e n t s o f e a c h l a t t i c e s t r u c t u r e b e i n g c o n n e c t e d v i a n o n - l i n e a r b r i d g e e l e m e n t s t o o n e a n o t h e r , w h e r e i n t h e i m p l a n t i s m a d e a t l e a s t p r e d o m i n a n t l y f r o m a p l a s t i c m a t e r i a l
Resumen de: US20260091160A1
Synthetic hemocompatible vascular grafts manufactured from polyvinyl alcohol-based biomaterials containing crystalline segments of polyvinyl alcohol, which are long-term fully functioning vascular grafts that provide no activity towards immune systems in recognizing surfaces as foreign bodies that would normally lead to fibrosis, platelet activation and subsequent thrombi formation, and thus occlusion of the grafts.
Resumen de: US20260091161A1
There is provided a hydrogel string for encapsulating a biological material. The hydrogel string has a thiol-ene crosslinked polymer with a first side-chain functionalized backbone polymer functionalized with an activated alkene crosslinked with a free or protected thiol-containing group present on a second side-chain functionalized backbone polymer. The biological material is encapsulated within the thiol-ene crosslinked polymer.
Resumen de: US20260091555A1
Dental restoration technologies include dental prosthesis components such as implants, abutments, crowns, and the like that are mapped to a patient's mouth prior to and during installation. Fabricating at least a portion of one or more components of the dental prosthesis using a fully calibrated and characterized fabricator can reduce sources of error that affect the success of fabrication and installation processes. The components of the dental prosthesis are represented by library files that are tailored to reflect particular characteristics of the components of the prosthesis to be fabricated, the fabricator, the material used during fabrication, and/or the environment surrounding the fabricator. The library files may be determined based on an acquired scan of the patient and/or based on inputs received from a user during the design process. The library files may be generated using virtual modeling techniques, and/or based on a component design that falls within pre-determined parameters.
Resumen de: US20260090892A1
An orthopedic knee prosthesis includes a femoral component, a tibial bearing, a tibial component, a first magnetic portion associated with the femoral component and including a first pole having a first pole polarity the first magnetic portion not physically interrupting any articulating portion of the curved medial condyle surface or curved lateral condyle surface, and a second magnetic portion associated with one or both of the tibial bearing and/or the tibial component and including a second pole having a second pole polarity, the second pole polarity the same as the first pole polarity, the second magnetic portion not physically interrupting any articulating portion of the concave medial bearing surface or concave lateral bearing surface, wherein the first pole and the second pole are in sufficient proximity to each other such that a magnetic repulsive force is present therebetween.
Resumen de: AU2024328750A1
Process for methacrylation of dECM comprising placing a carbonate buffer with a concentration of 1M in the reaction vessel and heating to a temperature of 50 °C, adding dECM to the carbonate buffer to obtain a dECM solution with a concentration of 4% (w/v), sterilizing this solution by irradiation with radiation UV for 15 minutes, adding methacrylic anhydride in an amount of 0.5 mL/1g dECM and reacting at 50 °C for 1 h, then adding a phosphate-buffered saline solution to obtain a 5-fold dilution of the mixture, placing the obtained solution in dialysis tube, and then placing the dialysis tube in deionized water, this stage is carried out at a temperature of 40 °C for no longer than 4 days, after completing this stage, the solution contained in the dialysis tubes is transferred to aluminum trays and then placed at a temperature -80 °C for at least 3 hours, then the frozen solution is freeze-dried under the following conditions: shelf temperature 10 °C, pressure 0.1 mba, freeze-drying time 48 hours. The invention also relates to methacrylated dECM obtained by the above method and to the use of methacrylated dECM obtained by the above method in the bioprinting process.
Resumen de: WO2024240762A1
The present invention relates to a process for producing a Pharmaceutical dosage form by powder bed fusion selective laser 3-dimensional printing, in particular selective laser sintering 3-dimensional printing (SLS), and a pharmaceutical dosage form manufactured by that process.
Resumen de: CN121754718A
本发明属于组织工程与创面修复领域，涉及一种用于慢性创面修复的复合型水凝胶敷料及其制备方法和应用，该制备方法包括：S1、将肉桂醛分散在明胶水溶液中，反应充分后透析至溶液澄清；冷冻干燥后得到肉桂醛接枝的改性明胶；S2、将祛褥生肌粉、S1得到的肉桂醛接枝的改性明胶、甲基丙烯化明胶、光引发剂在PBS溶液中混合，得到混合溶液；S3、向S2得到的混合溶液中加入Ga(NO3)3·6H2O溶液，得到水凝胶前驱体溶液；S4、使用S3得到的水凝胶前驱体溶液进行3D打印，光固化，得到复合型水凝胶敷料。本发明中，通过GelMA、CA‑Gel与镓离子形成的三维网络对药粉进行包埋与缓释，实现对慢性创面的高效抗菌、促愈和结构支撑，提升治疗效果与使用安全性。
Resumen de: EP4306235A2
Methods and systems are provided for using optical interferometry in the context of material modification processes such as surgical laser or welding applications. An imaging optical source that produces imaging light. A feedback controller controls at least one processing parameter of the material modification process based on an interferometry output generated using the imaging light. A method of processing interferograms is provided based on homodyne filtering. A method of generating a record of a material modification process using an interferometry output is provided.
Resumen de: CN121754723A
本发明涉及生物医用材料技术领域，具体涉及一种多材料3D打印仿生梯度软‑硬一体化水凝胶及其制备方法和应用。本发明基于高强度超分子N‑丙烯酰甘氨酰胺与乙烯基磷酸的共聚体系，采用DLP多材料打印技术将NAGA水溶液和NAGA‑VPA水溶液打印成梯度结构的水凝胶，然后依次浸泡于钙磷混合水溶液（Ca/P=1.67）、氨水、氯化钙水溶液和去离子水中，以实现羟基磷灰石（HAP）的原位梯度沉积及熟化。本发明制备的多材料3D打印仿生梯度软‑硬一体化水凝胶具备连续生化‑力学梯度，其中，表层低模量区匹配软骨性能，深层高矿化区整合骨组织，过渡区HAP结晶度呈空间依赖性分布，适用于骨软骨缺损修复及仿生关节假体的制造。
Resumen de: CN121754330A
本发明公开了一种基于生物力学的正畸矫治器设计方法、系统及正畸矫治器，涉及牙齿矫正技术领域，所述方法包括：获取目标对象的口腔信息，并根据所述口腔信息构建初始牙颌数字模型；根据所述初始牙颌数字模型确定优化咬合关系的目标牙颌数字模型，并根据所述目标牙颌数字模型生成正畸矫治器模型；根据所述初始牙颌数字模型及目标牙颌数字模型分别计算各牙齿的移动轨迹；根据所述移动轨迹修正所述正畸矫治器模型，以在所述正畸矫治器模型的齿槽中形成交替排布的挤压部和避让部。采用本发明，能够使得牙齿自然排齐，同时降低牙根吸收或牙槽骨损伤的风险，保证对牙齿的矫治效果。
Resumen de: PL452934A1
Przedmiotem zgłoszenia jest bioaktywny implant zawierający rusztowanie złożone z warstw polimerowych i kompozytowych o budowie włóknistej, które pokryte jest warstwą hydroksyapatytu i wzbogacone w nośnik z substancją biologicznie aktywną, charakteryzujący się tym, że rusztowanie ma strukturę warstwową, na którą składają się warstwy materiału głównego i warstwy materiału elastycznego i w którym to rusztowaniu warstwy materiału głównego stanowią od 50% do 99% ilości wszystkich warstw, tak, że pozostałą ilość warstw stanowią warstwy materiału elastycznego, przy czym materiał główny stanowi kompozyt o osnowie poli (ϵ—kaprolaktonu), o stopniu dyspersyjności w zakresie od 1,7 do 4,3 i maximum piku rozkładu masy cząsteczkowej w zakresie od 40 do 100 kDa, z dodatkiem od 40% wag. do 60% wag. dwufazowej ceramiki fosforanowo—wapniowej, o stosunku masowym hydroksyapatytu i ortofosforanu (V) wapnia 50:50, a materiał elastyczny bazuje na poli(ϵ—kaprolaktonie), o stopniu dyspersyjności w zakresie od 1,7 do 4,3 i maximum piku rozkładu masy cząsteczkowej w zakresie od 40 do 100 kDa, przy czym każda warstwa materiału głównego i materiału elastycznego ma grubość od 0,8% do 0,95% średnicy włókien, z których jest wytworzona, a rusztowanie ma strukturę porowatą, o otwartych porach między włóknami, tworzących trójwymiarową sieć połączonych kanałów, stanowiących od 40% do 80% objętości całkowitej rusztowania oraz zaw
Resumen de: WO2025031978A1
The invention relates to a polypeptide that is excellently suited for use in an ink for 3D printing. Furthermore, the present invention also relates to a polynucleotide that encodes the polypeptide according to the invention, and to a host cell that expresses the polypeptide according to the invention. Another embodiment is a method for producing an ink for 3D printing, wherein the ink contains a polypeptide. Additional embodiments relate to methods for producing a 3D scaffold and to the 3D scaffold that can be obtained by said methods, including for use in medicine.
Resumen de: CN121732829A
本发明公开了金属玻璃仿生人工骨植入体激光粉末床熔融增材制造方法，属于增材制造技术与生物医用材料技术领域，采用激光粉末床熔融技术，通过三维模型设计、调控激光工艺参数，在不同位置成形具有不同孔隙率的显微组织，从而实现具有梯度孔隙结构的人工骨植入体一体化成形；本发明从三维建模和工艺参数两个角度出发，可在宏观、介观、微观三个层级实现对零件内部孔隙结构的控制，显著提升金属玻璃植入体的能量吸收能力及细胞组织渗透能力，并能有效降低金属玻璃植入体的弹性模量，实现对植入体性能的综合调控，有效缓解应力屏蔽效应，增强金属玻璃植入体整体的稳定性，有助于金属玻璃仿生人工骨植入体在人体骨缺损修复临床治疗中的应用。
Resumen de: AU2024326857A1
Methods, systems, and devices for a wearable ring device are described. A wearable ring device may include a ring-shaped housing and a printed circuit (PCB) that at least partially contacts an inner shell of the ring-shaped housing. Light-emitting components and light-receiving components may be disposed on a first surface of the PCB and may extend through an aperture(s) in the inner shell such that the lightemitting and light-receiving components are substantially flush with an inner ringshaped surface of the inner shell. Optical lenses may cover the light-emitting and lightreceiving components within the aperture(s). In some cases, the optical lenses may be molded over the light-emitting and light-receiving components before the PCB is inserted into the ring-shaped housing. In other cases, the optical lenses may be molded over the light-emitting and light-receiving components (and the aperture(s)) after the PCB is inserted into the ring-shaped housing.
Resumen de: WO2026063621A1
This finger-wearable electronic device may comprise: a ring-shaped housing; a printed circuit board (PCB) disposed in the ring-shaped housing; and a sensor package mounted on the PCB. The sensor package can include an enclosure including a first light-transmitting portion, a second light-transmitting portion and a partition wall between the first light-transmitting portion and the second light-transmitting portion. The partition wall can include a surface that defines a portion of the exterior of the sensor package. The sensor package can include a first sensor. The first sensor can include: a light-emitting unit disposed under the first light-transmitting portion; and a reception unit disposed under the second light-transmitting portion. The sensor package can include a second sensor including electrodes. The electrodes of the second sensor can be disposed on the surface of the partition wall.
Resumen de: AU2025260012A1
The present invention relates to a 3D scaffold implant system for mandibular reconstruction, featuring a scaffold structure that includes at least four scaffold segments strategically positioned within the implant, the segments ensuring precise placement within a subject's jawbone and facilitate optimal integration with a surrounding bone tissue; a fluid delivery tube system integrated into each of the scaffold segments to administer a growth factor(s) and an antibiotic directly into the scaffold implant; a pump that facilitates controlled delivery of the growth factors into the scaffold segments; at least three fixation that provide stability to the implant and micro-motors that enable precise alignment of the scaffold implant to conform seamlessly to the natural curvature of the jawbone.
Resumen de: WO2026062286A1
The invention relates to diagnostic method software for providing data for producing an occlusive mouthguard for a person, wherein an actual tooth space state and/or tooth position (1) and an actual jaw function (2) are acquired, wherein - an actual body posture (3) is acquired, and - an actual plantar pressure (4) is acquired, and - the actual tooth space state and/or tooth position (1) is compared with a target tooth space state and/or tooth position (11) in order to determine a first deviation (a) between the actual tooth space state (1) and the target tooth space state (11), - the actual jaw function (2) is compared with a target jaw function (12) in order to determine a second deviation (b) between the actual jaw function (2) and the target jaw function (12), - the actual body posture (3) is compared with a target body posture (13) in order to determine a third deviation (c) between the actual body posture (3) and the target body posture (13), - the actual plantar pressure (4) is compared with a target plantar pressure (14) in order to determine a fourth deviation (d) between the actual plantar pressure (4) and the target plantar pressure (14), wherein - the acquired data are used to produce the occlusive mouthguard, in a manner suitable for reducing the deviations (a, b, c, d).
Resumen de: WO2026062246A1
The present disclosure provides methods for manufacturing of gap free, cement free, abrasion free dental implant devices. Dental implant devices manufactured according to the disclosed methods are also provided.
Resumen de: WO2026062644A1
Photoblocker usable in additive manufacturing a three-dimensional object are disclosed. Photocurable formulations comprising the photoblockers are also disclosed. The photoblocker can be beneficially included in formulations usable in additive manufacturing of 3D objects featuring a biological material in at least a portion thereof.
Resumen de: WO2026062643A1
A photocurable formulation usable in additive manufacturing a three-dimensional object is disclosed. The formulation features, in at least a portion thereof, a biological or a biocompatible material, the photocurable formulation comprising a photoinitiator, a photocurable biological or biocompatible material, and a carrier, the formulation further comprising at least two photocurable polymeric materials. Implants comprising same are also disclosed.
Resumen de: US20260085448A1
An inorganic structure having mechanical properties that differ depending on the region in the inorganic structure, and a method for manufacturing the inorganic structure are provided. An inorganic structure (1) of the present embodiment includes a plurality of solidified portions (SA) composed of an inorganic material. The plurality of solidified portions (SA) include a first solidified portion (SA1) having a first crystallographic direction (CO1) preferentially oriented in a predetermined direction, and a second solidified portion (SA2) having a second crystallographic direction (CO2) that is a different orientation from the first crystallographic direction (CO1).
Nº publicación: US20260085975A1 26/03/2026
Solicitante:
UNIV OF SOUTHERN CALIFORNIA [US]
WILLIAM MARSH RICE UNIV [US]
UNIVERSITY OF SOUTHERN CALIFORNIA,
WILLIAM MARSH RICE UNIVERSITY
Resumen de: US20260085975A1
The present disclosure relates to a custom waveguide array to encode 3-dimensional data for snapshot imaging techniques like imaging spectrometry or volumetric spectral domain OCT. The custom waveguide array has a series of waveguides such as optical fibers having input ends and output ends. The input ends are grouped in a dense array input area. An array output area creates void spaces for the output ends. The output area thus may used to provide spectral information for an object imaged by the input area. The fiber arrays may be manufactured with an entirely automatic development process based on 3-D printing techniques such as 2-Photon Polymerization (2PP) additive manufacturing.
BOPI
Sede Electrónica
