3D bioinprimaketa

三维仿生角膜基质支架的梯度生物墨水及3D打印制备工艺

Resumen de: CN120714102A

本发明提供三维仿生角膜基质支架的梯度生物墨水及3D打印制备工艺，所述梯度生物墨水包含5‑30份天然聚合物基质、2‑8份生物活性因子、1‑5份细胞成分、1‑10份光固化剂及60‑95份生理盐水。天然聚合物基质含甲基丙烯酰化明胶、胶原/透明质酸蛋白复合物和壳聚糖，其中胶原/透明质酸复合物经赖氨酰氧化酶交联与可见光光固化制得。生物墨水制备后，采用挤出式3D打印机，在特定条件下逐层打印，同步以紫外光照射，制得三维仿生角膜基质支架。本发明支架具有良好的力学性能、透光性及细胞相容性，可支持干细胞定向分化，适用于角膜修复。

一种个性化牙齿3D打印设备及其方法

Resumen de: CN120716173A

本发明涉及打印设备技术领域，且公开了一种个性化牙齿3D打印设备及其方法，包括打印机和设置在打印机上的料盒，所述打印机内设置有成型板，还包括：升降部，所述升降部安装在打印机上；安装部，所述安装部设置在打印机上；所述升降部包括传动组件，所述传动组件设置有两个，两个所述传动组件均安装在打印机上；以及动力组件，所述动力组件设置在打印机上；所述传动组件包括固定连接在打印机上的固定杆一，所述固定杆一内滑动连接有滑杆一。本发明通过设置设置升降部，解决了现有的打印设备在使用过程中，动力传递多采用单组齿轮齿条或简单连杆结构，难以保证两侧运动的同步性，成型板易出现倾斜或偏移，导致打印材料堆叠不均匀问题。

一种多材料药片3D打印装置

Resumen de: CN223392685U

本实用新型涉及一种多材料药片3D打印装置，属于医疗器械技术领域，包括：机架、成型系统、供粉系统及喷液系统，机架的内部固定有固定板且固定板上设有长条孔；成型系统沿X轴滑动在长条孔内；供粉系统包括支撑架和多个供粉斗，支撑架固定在固定板上；多个供粉斗沿X轴方向间隔固定在支撑架上且其漏粉孔可分别与多个容粉孔相对布置；喷液系统包括Y轴驱动机构和多个喷射器，Y轴驱动机构固定在机架上且其驱动端沿Y轴方向往复移动；多个喷射器间隔固定在Y轴驱动机构的驱动端。本实用新型突破传统3D打印机单一配比打印药物的设计束缚，匹配全新的药物喷射粘结技术，可以灵活配比多种材料，提高药片的成型效率和成型效果。

一种异种骨-微孔金属植入物复合材料的制备方法

Resumen de: CN120714106A

本发明公开了一种异种骨‑微孔金属植入物复合材料的制备方法，属于生物技术领域；将微孔金属植入物植入到异种动物松质骨中，经过12周时间，微孔金属植入物与异种动物松质骨进行骨整合连接，形成界面互穿结构，将微孔金属植入物取出，保留1mm‑10mm厚度的周围骨，再依次进行梯度脱钙和完全脱细胞处理，获得具有高骨诱导活性、强骨整合性和低免疫原性的异种骨‑微孔金属植入物复合材料；本发明将金属植入物材料转变为生物活性植入物复合材料，将金属植入物与移植骨的异质界面转变为宿主骨或移植骨与移植骨的同质界面，解决了移植骨与金属植入物界面骨整合不良的临床难题。

用于改变颏短平形态的颏成形导板系统及其制作方法

Resumen de: CN120713588A

本发明提供了一种用于改变颏短平形态的颏成形导板系统及其制作方法，颏成形导板系统包括截骨导板和定位导板，所述截骨导板包括第一定位孔、第二定位孔和第三定位孔，并且限定了第一截骨骨块、第二截骨骨块和截骨去除骨块的切割引导路径，所述第一定位孔、所述第二定位孔和所述第三定位孔分别对应于所述第一截骨骨块、所述第二截骨骨块和下颌骨固位区域上的连接孔位；所述定位导板用于将截取的所述第一截骨骨块和所述第二截骨骨块限定在依据手术规划的目标位置，其包括第四定位孔、第五定位孔和第六定位孔，所述第四定位孔、所述第五定位孔和所述第六定位孔分别对应于所述第一截骨骨块、所述第二截骨骨块和所述下颌骨固位区域上的连接孔位。

布置多个齿科模型的方法

Resumen de: CN120716178A

本申请涉及一种布置多个齿科模型的方法，该方法包括：将多个齿科模型分为牙模模型和非牙模模型；将至少两个牙模模型编为一组；将至少一个非牙模模型编为一组；并且对至少一组牙模模型和/或至少一组非牙模模型进行排版。本申请能够兼顾批量3D打印制造的效率和后续分拣的简便性。

一种黑陶香薰器皿及其制备方法

Resumen de: CN120695233A

本发明公开了一种黑陶香薰器皿，包括有壶体主体、香薰托盘、内置陶芯模块，内置陶芯模块采用中空多孔陶块，可吸附精油或香料，可拆卸更换，壶体主体的内壁覆有高温相变陶瓷微球涂层，由以下重量份的原料组成：高岭土40-50％；黏土15-25％；长石5-8％；石英粉5-10％；硅藻土5-10％；负离子矿石粉2-5％；高温相变陶瓷微球1-3％；植物灰或碳粉1-2％。本发明壶体内壁采用高温相变陶瓷微球+透明陶瓷溶胶涂层，不仅提升陶器的热储存与热释放能力，还能稳定释放负离子，具有净化空气、增强香薰效能、缓释香气的功能，香薰壶配有可拆卸的中空多孔陶芯模块，模块结构具有良好吸附与透气性能，可反复使用或替换不同香型香料，用户体验佳、经济耐用。

用于经由装载有API的组织穿透器递送药物的装置和方法

Resumen de: WO2024163831A1

A drug delivery device includes a substrate; and a plurality of tissue penetrating members 3D printed onto the substrate and configured to embed into tissue, wherein at least one of the plurality of tissue penetrating members is configured to anchor the drug delivery device to the tissue; and at least one payload comprising at least one API loaded into at least one of the substrate and the plurality of tissue penetrating members for absorbing into the tissue when the at least one tissue penetrating member is embedded in the tissue.

3D打印水凝胶前驱体溶液、固化产物及其制备方法和应用

Resumen de: CN120699378A

本申请涉及材料技术领域，提供了3D打印水凝胶前驱体溶液、固化产物及其制备方法和应用。该3D打印水凝胶前驱体溶液，按质量百分数计，包括如下组分：表面活性剂5％～35％、丙烯酰胺5％～30％、疏水单体0.5％～5％、水溶性聚合物0.05％～5％、光引发剂1％～5％，余量为硫酸钠溶液。本申请的3D打印水凝胶前驱体溶液，适用于光固化3D打印，能够在光作用下固化形成3D打印水凝胶，形成的3D打印水凝胶同时兼具良好的力学性能和自修复特性，在一些对强度、持久性要求较高的应用场景下具有良好的适应性，具有广阔的推广应用前景。

一种3D打印前臂假肢

Resumen de: CN223380672U

本实用新型涉及假肢技术领域，且公开了一种3D打印前臂假肢，包括内外接受腔，所述内外接受腔的表面套接有上仿真皮，所述内外接受腔的表面设有透气孔和盖板、弹簧伸缩杆、挡板。本实用新型结构合理，通过CT扫描得到患者前臂残肢的数字模型，镜像得到残肢侧外形，提高假肢接受腔舒适性及假肢外观，通过旋转正反螺纹丝杠，使左夹具向右移动，同时右夹具向左移动，从而使左夹具和右夹具将螺栓夹紧固定，同时使假肢手与内外接受腔固定连接，通过旋转固定丝杠，使移动座和清洁结构向下移动，通过清洁结构可对透气孔部位进行清理同时对内外接受腔内部的汗水进行吸附，通过导热管将导热座内部的热量排入散热磷内部，再通过散热磷将热量由透气孔排出。

APPARATUS FOR PRODUCING TABLETS

Resumen de: WO2025195853A1

The invention relates to an apparatus (1) for producing tablets (2), wherein the apparatus (1) comprises a precursor material production device (3) and an additive manufacturing device (4), wherein the precursor material production device (3) is designed to coat granulate particles (6) containing a medicament (5) with a coating agent (8) comprising a thermoplastic material (7) in order to produce precursor material particles (9), and wherein the additive manufacturing device (4) is designed to produce tablets (2) from a powdered precursor material (10) comprising a plurality of precursor material particles (9) by selective laser sintering.

STRUT STRUCTURE

Resumen de: WO2025194222A1

An expandable strut lattice structure for a structural component, the structure comprising extendable struts.

RADIATION-CURABLE COMPOSITION FOR USE IN A RAPID PROTOTYPING PROCESS OR A RAPID MANUFACTURING PROCESS

Resumen de: US2025297044A1

Polymerizable, radiation-curable compositions are provided and comprise (i) monomers and (ii) at least one further component, wherein the (i) monomers comprise (a) at least one urethane (meth)acrylate that is at least difunctional, (b) at least one monofunctional acrylate having an alicyclic group and/or at least one monofunctional methacrylate having an alicyclic group, and (ii) the at least one further component comprises (c) at least one photoinitiator for the UV and/or visible range or a photoinitiator system for the UV and/or visible range. The compositions are usable for producing, via a rapid prototyping, manufacturing, or tooling process, dental prosthetic parts, orthopaedic instruments, or dental pre-forms that have a flexural strength of greater than or equal to 75 MPa, a modulus of elasticity of greater than or equal to 2600 MPa, and/or a water absorption of less than 45 μg/mm3.

SURGICAL CLAMP

Resumen de: AU2024235637A1

A surgical clamp for providing a stable mechanical grasp and stabilisation of bone during an orthopaedic surgical procedure, comprising: a first arm comprising: an extended section comprising a mount at the distal end thereof; and a first jaw portion located at the distal end of the first arm; a second arm comprising: a fastening platform located at the proximal end of the second arm; and a second jaw portion located at the distal end of the second arm; engagement means comprising a bolt to engage the first arm with the second arm about a pivot point formed by the engagement means to provide relative rotation of the first and second arms between: an open configuration whereby first jaw portion and second jaw portion are urged apart; and a clamped configuration whereby first jaw portion and second jaw portion are urged into clamping engagement with the patient's bone in use during the surgical procedure; a fastening component comprising a fastening bolt and a fastening nut, adapted to engage the first and second arm into a locked clamped configuration about the bone of a patient during the surgical procedure; and a handle adapted to be gripped by a surgical assistance for stabilisation of the patient's joint or bone during the surgical procedure.

Impact Resistant Material

Resumen de: US2025297834A1

The current disclosure is directed to an impact resistant material made from a novel melanin composite. It has been found that using these composites allows for the production of effective ballistic protection and blast containment materials.

MULTI-VALENT POLYMERIZABLE COMPOSITIONS AND METHODS OF PRODUCING AND USING THE SAME

Resumen de: US2025297052A1

The present disclosure provides photo-polymerizable components, photo-curable resins comprising one or more of such monomers, as well as polymeric materials formed from the photo-curable resins. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

COLLAGEN-CONTAINING CURABLE FORMULATIONS

Resumen de: US2025295791A1

A conjugate made of collagen and a plurality of curable elastic moieties covalently attached thereto, a curable formulation (e.g., a bioink composition) that comprises the conjugate and additive manufacturing of a three-dimensional object which utilizes the curable formulation are provided. Also provided are methods/processes of additive manufacturing that employ collagen that feature a plurality of photocurable groups, in which the viscosity of a collagen-containing formulation is determined by manipulating an amount of the photoinitiator that is mixed with the collagen.

CHAOTIC PRINTING FOR THE PRODUCTION OF NON-FILAMENTOUS ARCHITECTURES

Resumen de: US2025296278A1

Disclosed are methods for preparing non-filamentous scaffolds (e.g., sheets) for cell or tissue culture. These methods can comprise providing at least a first printing composition (e.g., a bioink) and a second printing composition (e.g., a bioink or a fugitive ink); chaotic printing the first printing composition and the second printing composition to generate a microstructured precursor comprising a plurality of lamellar structures formed from the first printing composition and the second printing composition; extruding the microstructured precursor through a nozzle (e.g., a fan-shaped nozzle, a curved fan-shaped nozzle, or an annular nozzle) to produce a non-filamentous microstructured precursor; and curing the non-filamentous microstructured precursor to provide the non-filamentous scaffold for cell or tissue culture.

FUNCTIONALLY-DIVIDABLE ORODISPERSIVE DOSAGE FORM

Resumen de: US2025295593A1

A dividable tablet with a functional seam for functionally dividing the dividable tablet into substantially equivalent sub-dosage units along the functional seam. The functional seam is configured to subdivide the sub-dosage units into the same mass within a tolerance of about 3% or less, and typically of 1.0% or less. The functional seam is configured reduce the amount of lost material that separates from the divided sub-dosage units after division of the dividable tablet along the functional seam, to less than 3%, and typically less than 1.0%, and more typically less than 0.1% of the mass of the undivided dividable tablet.

ADJUSTABLE BRACE AND PROCESSES FOR MAKING AND USING SAME

Resumen de: US2025295513A1

An adjustable brace for stabilizing a body part of a patient and a method of fabricating such a brace is provided. In some embodiments, the adjustable brace comprises a first stabilizer having a first exterior surface, a first interior surface, a first thickness, and a plurality of first stabilizer guides; a second stabilizer comprising a second exterior surface, a second interior surface, a second thickness, and a plurality of second stabilizer guides; and at least one flexible lacing member extending along the first and second stabilizer guides, wherein the flexible lacing member adjustably secures the first stabilizer to the second stabilizer. Additional embodiments further include a closure mechanism to assist in the flexible lacing member adjustment.

3D PRINTED MATERIALS AND METHODS

Resumen de: US2025295839A1

Aspects of the present disclosure generally relate to 3D printed scaffolds for attaching a radionuclide and methods of use thereof. In some embodiments, 3D printed scaffolds comprising a first layer and/or a second layer, and a radionuclide, are provided. In some embodiments, methods for capturing a radionuclide using said 3D printed scaffolds, are provided. In some embodiments, methods of using 3D printed scaffolds with a radionuclide to capture a daughter radionuclide product at a location different than the 3D printed scaffold, are provided.

EQUINE NASOGASTRIC TUBE MODEL AND RELATED METHODS

Resumen de: US2025299602A1

Systems and associated method of fabrication of anatomically accurate animal training models can comprise fabricating at least one inverse anatomical feature representative of an anatomical feature in an animal's head, forming a mold of the animal's head, connecting the at least one inverse anatomical feature in the mold of the animal's head, filling the mold of the animal's head with a filling material, and removing the cast head from the mold.

CERAMIC PROCESSING FOR THE DIRECT MANUFACTURE OF CUSTOMIZED LABIAL AND LINGUAL ORTHODONTIC BRACKETS

Resumen de: US2025298391A1

A method of manufacturing customized ceramic labial/lingual orthodontic brackets by digital light processing, said method comprises measuring dentition data of a profile of teeth of a patient, wherein measuring dentition data is performed using a CT scanner or intra-oral scanner, based on the dentition data, creating a three dimensional computer-assisted design (3D CAD) model of the patient's teeth using reverse engineering, and saving the 3D CAD model on a computer, designing a 3D CAD bracket structure model for a single labial or lingual bracket structure, importing the 3D CAD bracket structure model into a Digital Light Processing (DLP) machine, directly producing the bracket by layer manufacturing.

ACOUSTIC FLUID-MEDIATED BOTTOM-UP BIOPRINTING DEVICE FOR FUNCTIONAL ORGANS WITH ULTRAHIGH CELL DENSITY AND PRINTING METHOD THEREFOR

Resumen de: US2025297202A1

An acoustic fluid-mediated bottom-up bioprinting device for functional organs with an ultrahigh cell density and a printing method are provided, the acoustic fluid-mediated bottom-up bioprinting device includes an array SAW chip, a printing container, a printing platform and a curing light source; the printing container is used for containing a printing ink; the printing platform is able to move upward and downward in the printing ink; the array SAW chip includes a plurality of interdigital electrodes; a central axis of each interdigital electrode deflects from a direction towards a center of the circle; the array SAW chip is in contact with the printing ink and is able to form a focused acoustic flow to aggregate the cells in the printing ink; the curing light source is able to expose a projection into the printing ink above the printing platform and cure the printing ink above the printing platform.

口腔インプラント材料の製造方法

Nº publicación: JP2025138476A 25/09/2025

Solicitante:

王偉建

Resumen de: JP2025138476A

【課題】口腔インプラント材料の製造方法を提供する。【解決手段】複数の標準金属インゴットに金属材料を使用して歯根部を印刷して、金属基盤を得て、金属基盤の周囲に歯槽修復材料５を印刷し、選択的レーザー溶解プロセスが歯根部の印刷に使用され、溶融堆積プロセスが歯槽修復材料の印刷に使用される。本発明は、１回の印刷で複数の患者用のインプラント材料を同時に製造する。【選択図】図５