3D bioinprimaketa

一种用于口颌面畸形的矫正修复器及其制作方法

Resumen de: CN121465752A

本发明公开了一种用于口颌面畸形的矫正修复器及其制作方法，属于口腔医学修复与矫正技术领域，其修复器包括上颌组件和下颌板，上颌组件下端连上支撑组件，下颌板上端两侧连下支撑杆；上支撑组件和下支撑杆远离颌部一侧连用于套设牙齿的上、下套托，上套托和下支撑杆另一侧连多个托槽组件；托槽组件含单晶氧化铝陶瓷托箱、医用不锈钢封闭板及伸缩连杆；上支撑组件的上支撑杆与下支撑杆端部分别设氧化锆陶瓷上、下咬合块；制作时，通过口内扫描、影像确定参数，CAD设计部件，采用激光烧结和3D打印模型，装配各部件后佩戴。

一种集成剪切激活微胶囊的自固化角蛋白3D打印墨水及其制备方法

Resumen de: CN121466382A

本发明一种集成剪切激活微胶囊的自固化角蛋白3D打印墨水及其制备方法，属于生物3D打印和智能材料技术领域，将高分子量可溶性角蛋白粉末溶解于pH为6.5‑8.5的生物相容性水性介质中，混合均匀，脱泡后得到角蛋白基液；将芯材包裹于相应的外壳内，得到成平均粒径为1‑10 μm的微胶囊；在搅拌条件下，将所述微胶囊均匀地分散到0~8°C的角蛋白基液中，直至形成均一的悬浮体系，得到集成剪切激活微胶囊的自固化角蛋白3D打印墨水。墨水的固化过程内化于打印行为本身，简化了打印流程，降低了设备成本和操作难度。由于交联剂被有效隔离，墨水在打印前可稳定储存数周而不会发生凝胶，解决了双组分墨水混合后必须立即使用的难题。

一种仿生骨支架定制体及其制备方法与应用

Resumen de: CN121468962A

本发明涉及一种仿生骨支架定制体及其制备方法与应用，属于生物医药材料技术领域。本发明提供了仿生骨支架定制体的制备方法，包括以下步骤：扫描记录颅颌面硬组织缺损形态，基于所记录得到的数据通过算法模型和/或人工设计构建得到数字化支架模型；所得数字化支架模型进行三维重建，生成符合颅颌面组织缺损个性化需求的仿生骨支架定制体数据；利用3D打印技术将所得仿生骨支架定制体数据转化为仿生骨支架定制体。本发明利用真实骨缺损数据进行建模，通过3D打印技术制备骨缺损部位的仿生骨支架定制体，外轮廓与骨缺损侧形态贴合并重建骨理想形态，内轮廓为缺损部位的精细亚结构，具备仿生孔隙结构和生物力学性能，可用于重建个性化颅颌面组织。

一种适用于增材制造的骨骼材料及其制备方法

Resumen de: CN121466360A

本发明公开一种适用于增材制造的骨骼材料及其制备方法，方法包括以下步骤：S1、将CNTs加入乙醇中，搅拌，超声分散，获得CNTs乙醇分散液；S2、将PEEK粉体加入CNTs乙醇分散液中，搅拌，超声分散，获得CNTs‑PEEK‑乙醇共混液；S3、将CNTs‑PEEK‑乙醇共混液搅拌直至重量不再减少，获得CNTs‑PEEK粉体；S4、将CNTs‑PEEK粉体烘干后，挤出，获得CNTs‑PEEK线材；S5、将CNTs‑PEEK线材再次烘干后，利用高温融熔挤出打印，获得个性化骨骼支架；本发明提供了一种适用于增材制造的、力学性能好且不容易脆性断裂的骨骼材料及其制备方法。

一种修复膜及其制备方法

Resumen de: WO2025055408A1

The present invention relates to the technical field of biomaterials. Disclosed are a repair membrane and a preparation method therefor. The preparation method comprises the following steps: S1, preparing a polymer membrane; S2, mixing the polymer membrane with a natural polymer material solution, and performing unidirectional freezing to prepare a through hole structure; and S3, cross-linking a composite membrane of a polymer and a natural polymer material to obtain a repair membrane. According to the repair membrane and the preparation method therefor provided by the present invention, the repair membrane prepared takes a polymer material as a support and slow-degradation inner layer and takes a cross-linked natural polymer material having a unidirectional channel as a guide outer layer. When the present application is applied to repair of soft tissues such as smooth muscle, blood vessels, and tendons, a gelatin unidirectional channel can guide directed cell migration, adhesion, proliferation, and alignment, and a polymer of an inner layer can ensure the matching between the degradation rate of the material and tissue growth, so that the present invention can achieve a better tissue repair effect.

基于耳廓扫描与3D打印的耳穴电刺激戒烟仪及使用方法

Resumen de: CN121466489A

一种基于耳廓扫描与3D打印的耳穴电刺激戒烟仪及使用方法，能够贴合个体的耳型，使电极或刺激凸点能准确对应穴位，实现电刺激的精准定位与标准化操作，模拟针刺“得气”效应，增强戒断症状缓解与渴求抑制效果，实时监测佩戴时长、刺激次数与依从性，为医生提供客观量化的数据。其包括：三维扫描与个体建模模块，3D打印个体化耳夹主体，电刺激控制模块，信号输出与控制单元。

通过选择性激光烧结的新型药物剂型3D打印概念

Resumen de: WO2024240762A1

The present invention relates to a process for producing a Pharmaceutical dosage form by powder bed fusion selective laser 3-dimensional printing, in particular selective laser sintering 3-dimensional printing (SLS), and a pharmaceutical dosage form manufactured by that process.

超结构玻璃碳在促骨修复中的应用及骨修复材料的制备方法

Resumen de: CN121466359A

本发明属于材料制备技术领域，具体涉及一种超结构玻璃碳在促骨修复中的应用及骨修复材料的制备方法。本发明首先提供了一种骨修复材料，所述骨修复材料由一种经过表面改性的玻璃碳材料制备得到；所述玻璃碳材料具有各向应力均匀分布的稳定结构；所述超结构玻璃碳以三周期极小曲面的晶胞作为最小重复单元；经过表面改性后的玻璃碳材料具有珊瑚样或类珊瑚样形貌。本发明的骨修复材料可以实现诱导骨组织加速修复和再生，此外这种骨修复材料还兼顾了很好的力学性能。

一种牙齿3D打印机用可调节操作台

Resumen de: CN223874032U

本实用新型公开了一种牙齿3D打印机用可调节操作台，其包括耳块：所述耳块的表面转动连接有轴杆，所述轴杆的表面固定连接有连接件，所述连接件的表面通过螺栓固定安装有操作台，所述耳块的表面固定安装有L形板，所述L形板的表面焊接有圆壳，所述圆壳的内壁转动连接有转板，所述轴杆的端部固定连接有连接杆，所述转板的表面开设有滑槽。本实用新型通过滑杆的滑动拨动滑槽的内壁，使得转板通过连接杆带动轴杆转动，继而轴杆通过连接件带动操作台翻转适宜角度，即可达到可对牙齿打印机操作台的角度进行调节，以使得操作台的显示屏得以与不同使用者的视线角度相垂直，进而提高打印机操作台适用性的目的。

一种用于3D打印遗体整容的头部辅助定位装置

Resumen de: CN223874014U

本实用新型提供一种用于3D打印遗体整容的头部辅助定位装置，面罩覆盖在支撑基座上，面罩的左右两侧通过连接扣和支撑基座固定连接，支撑基座包括基底层、支撑层和固定层，基底层内部设有高度调节杆，支撑层和固定层的上端均为由后至前向下倾斜设置，支撑层前侧的中央设有头部固定槽，头部固定槽由后至前呈波浪式曲面结构，固定层前侧的中央设有三面围挡的头部固定口，头部固定口与头部固定槽配合，头部固定槽设有两条可调节绑带，两条可调节绑带之间通过扣环配合固定，头部固定口的内缘设有防渗液层；本实用新型通过支撑基座为头部提供稳定的支撑，确保头部保持稳定的姿态，头部固定高度可调、角度可调，适用于多种场景下的头部固定需求。

3D辅助下光线引导穿刺定向成套器械及其定向方法

Resumen de: CN121465686A

3D辅助下光线引导穿刺定向成套器械及其定向方法，属于医疗器械领域，发明包括设置在患者头皮且光线朝向患者头部的两个红外线或激光线性定位灯，两个线性定位灯通过角度调节装置设置在一个或两个支架上，所述两个线性定位灯的灯光可在头皮外周任意角度调节，两个线性定位灯的线性灯光在不同方向上，两个线性定位灯形成的线性光线分别经过患者头皮外周的两个定位标记，穿刺导管设置在头部外穿刺中心线的延长线上，穿刺辅助架支撑着穿刺导管，本发明可应对多种脑病灶穿刺定向，避免手术器械与患者面部与五官部位接触带来的伤害，可精准快速定向。

Additive manufacturing on machined assembled parts

Resumen de: AU2025205647A1

An implant having two adjacent solid parts, a third solid part disposed between the two solid parts, and a porous part extending from the solid parts. The implant is fabricated by a process that includes first assembling the solid parts before additively manufacturing the porous part on surfaces defined by the solid parts. This process may include positioning a first fabricated component adjacent to a second fabricated component such that a side surface of the first fabricated component and a side surface of the second fabricated component form a build surface. Then additively manufacturing a structure on the build surface such that the structure extends across and is permanently fixed to both of the side surfaces of the first and the second fabricated components such that the first and the second fabricated components form part of the implant. An implant having two adjacent solid parts, a third solid part disposed between the two solid parts, and a porous part extending from the solid parts. The implant is fabricated by a process that includes first assembling the solid parts before additively manufacturing the porous part on surfaces defined by the solid parts. This process may include positioning a first fabricated component adjacent to a second fabricated component such that a side surface of the first fabricated component and a side surface of the second fabricated component form a build surface. Then additively manufacturing a structure on the build surface such that th

MICROFLUIDIC ENGINEERING OF IMMUNE CELLS FOR IMPROVED THERAPEUTIC EFFICIENCY

Resumen de: WO2026030357A1

Disclosed herein is a microfluidic device for priming, collection and recovery of immune cells comprising: a) two separate fluidic channels: i) a first channel, wherein the first channel is infused with immune cells, and ii) a second channel, wherein the second channel acts as a collection reservoir for transmigrated cells, and; b) a microporous membrane interface, present between the first channel and the second channel, wherein the microporous membrane is functionalized on the first channel surface with adhesion molecules. Also disclosed are methods of creating enhanced cells, and using them in treatment of individuals in need thereof.

マイクロマニピュレータとして使用するためのツール及びその製造方法

Resumen de: WO2024120583A1

The invention relates to a tool for use as a micromanipulator and to a method for producing the tool. The tool consists of a plurality of parts in the form of - a frame (1) which is oriented along a longitudinal axis (L) and which is arranged as a hollow body around an interior, - at least one manipulator element (2) arranged on a first end face (1.1) of the frame (1), and - at least one actuation element (3) which is arranged on a second end face (1.2) opposite the first end face (1.1) and which is mounted slidably and axially movably in the interior of the frame (1), said parts being connected interlockingly and movably to one another by means of necessary connecting and bearing elements, and the tool being entirely generated by additive manufacture, including all the necessary gaps between the parts movably connected to one another. According to the method, the tool with all its parts and with the gaps between the movable parts is manufactured entirely by additive manufacture in one processing operation.

一种密孔型锌合金口腔膜

Resumen de: CN223861105U

本实用新型的目的在于提供一种密孔型锌合金口腔膜，其结构包括：锌合金膜，织物膜，织物膜覆盖在锌合金膜，锌合金膜利用粉末冶金技术成型，可以整体完全降解，还能够有效保持金属对于屏蔽空间的有效支撑，而织物膜具有微纳级孔隙率，与锌合金的密孔部分组成多级孔隙结构，增加了与营养物质的交换面积，克服了营养物质无法穿过金属膜的问题。

芳香剂递送系统

Resumen de: AU2024276549A1

Methods of manufacturing a porous device for diffusing a fragrance using additive manufacturing including iteratively spreading a loose powder and selecting at least one process parameter to create a porosity within the porous device adapted to carry the fragrance from a fragrance reservoir to an exterior surface of the porous device. An additively manufactured device for diffusing a fragrance includes a diffuser having a plurality of pores defining a porosity of the diffuser, the porosity defining at least one of a rate of absorption, an amount of storage, and a rate of diffusion of the fragrance. A method of using a porous device includes filling the plurality of pores with fragrance and diffusing the fragrance from an exterior surface.

錠剤用インクジェットインクセット、錠剤用混合インクジェットインクおよび錠剤印刷物

Resumen de: JP7810304B1

【課題】本開示は、優れた印刷安定性を保ちつつ、組み合わせる色素の種類によらず耐光性に優れ、かつ広い色域を再現できる錠剤用インクジェットインクセット、錠剤用インクジェットインクのシリーズ、錠剤用混合インクジェットインクおよび錠剤印刷物を提供することを目的とする。【解決手段】本実施形態に係る錠剤用インクジェットインクセットは、可食性の染料と、溶媒として水およびエタノールとを含み、前記染料の種類が互いに異なる複数の錠剤用インクジェットインクを備え、前記複数の錠剤用インクジェットインクのうち少なくとも１つには褪色抑制剤として還元イソマルツロースが含まれており、前記褪色抑制剤を含む前記錠剤用インクジェットインクにおける前記褪色抑制剤の含有量Ｆ［ｗｔ％］と、前記染料の含有量Ｄ［ｗｔ％］との比（Ｆ／Ｄ）が０．２以上３０．０以下の範囲内である。【選択図】図６

一种通过多参数协同控制的钴铬合金成型方法及牙科修复体

Resumen de: CN121447064A

本发明涉及金属增材制造技术领域，具体涉及一种通过多参数协同控制的钴铬合金成型方法及牙科修复体，成型方法包括如下步骤：1)粉末预处理：对钴铬合金粉末进行真空等离子活化得到活化处理的钴铬合金粉末；在活化处理的钴铬合金粉末表面附着纳米氧化物表面修饰剂得到预打印粉末；2)3D打印：在对步骤1)获得的预打印粉末打印过程中，采用梯度能量打印和动态气氛控制，获得钴铬合金成型件。本发明实现金属表面氧化层的精确可控生长，使氧化层厚度稳定在理想范围，以满足金瓷高强度结合的需求。

一种增材制造的空心髋臼杯假体及其制作方法

Resumen de: CN121445530A

本发明一种增材制造的空心髋臼杯假体及其制作方法涉及人工髋关节假体技术领域，包括依次连接的堵销、杯体以及多孔结构；杯体的内型面包括内端面、内球面、锥面、防旋凸耳安装槽和卡合槽，杯体的内型面用于安装臼衬；杯体的锥面被用于安装陶瓷衬，而内端面、内球面、防旋凸耳安装槽和卡合槽不与陶瓷衬接触；多孔结构附着在杯体的外型面上，其外型面呈半球形或半椭球形，止于长轴；多孔结构与杯体回转轴为短半轴；杯体的顶端设有一个用于术中安装的螺纹孔，杯体的端面上设有至少一个排粉孔并在排粉后安装堵销；杯体的内球面处不设置或设有至少一个用于安装植入初期固定的钛钉的钛钉孔；端面与外型面之间设有连通的空腔。

一种用于3D打印骨填充物的调整装置

Resumen de: CN223860972U

本实用新型公开了一种用于3D打印骨填充物的调整装置，涉及医疗器械技术领域。该一种用于3D打印骨填充物的调整装置，包括底座，所述底座一侧滑动设置有活动套。该一种用于3D打印骨填充物的调整装置，通过调节活动套和调节头的位置，使夹持机构位于需要连接位置处的正上方，在将桥接棒块固定后，向下压动齿杆，齿杆在压力左右下移动并使桥接棒块接近连接处，在进一步调节活动套与调节头的位置后，继续下压齿杆，由于限位齿轮被卡销阻挡，使得桥接棒块被精确紧密地压在连接处，使得桥接棒块在固定时更加稳定，且方便调节桥接棒块的位置，结构简单，操作方便，提高了手术效率。

一种骨缺损修复的羟基磷灰石/二氧化锆复合多孔支架的3D打印制备方法、支架和应用

Resumen de: CN121445944A

本发明涉及骨修复技术领域，尤其涉及一种骨缺损修复的羟基磷灰石/二氧化锆复合多孔支架的3D打印制备方法、支架和应用。本发明以CT/Micro‑CT重建获得个性化STL，采用高固含光敏陶瓷浆料（HA:ZrO2=25:75～45:55）进行DLP成形；经分段脱脂与分段烧结，在钙磷酸盐/ZrO2界面原位构建连续CaZrO3/或Ca2Zr7O16中间层（覆盖率60%～95%、厚度80～250nm），并保持t‑ZrO₂≥70%。所得TPMS/晶格支架孔隙率45%～70%、连通率≥97%，在多孔条件下仍具抗压≥45MPa、106次疲劳极限≥6MPa；通过受控冷却与SBF预活化可实现HA快速再生（t50≤24h、7d≥2μm）。该方法兼顾个性化成形、界面键合与早期成骨性能。

Three-dimensional implant with hydrophilic surface

Resumen de: TW202510819A

The disclosure provides a 3D tissue reconstruction implant having a hydrophilic implant surface and consisting of a bio-resorbable material, wherein the implant surface is considered hydrophilic when assessed using an ink test following ISO 8296:2003 and adapted to a 3D surface, wherein said ink test comprises incubating the implant for 1 min in a solution consisting of an ink with a surface tension of 72 mN/m and water and wherein after incubation of the implant in said solution an ink colored implant surface is indicative for a hydrophilic implant surface. The disclosure also provides said implant for use in tissue reconstruction, (soft) tissue support, tissue augmentation and/or implant revision and the use of said implant for reconstructing, augmenting and/or revising a tissue and/or supporting a (soft) tissue, respectively, wherein the implant is inserted into a patient. Further the disclosure provides a method of manufacturing a tissue reconstruction implant with a hydrophilic implant surface.

3 3 Method for Preparing 3D bioprinting structure and 3D bioprinting structure by Thereof

Resumen de: KR20260014071A

본 발명은 3차원 바이오프린팅 구조물의 제조방법 및 상기 방법으로 제조된 3차원 바이오프린팅 구조물에 관한 것으로, 본 발명에 따르면, 기존에는 프린팅이 어렵던 높은 세포적합성의 저점도 생체수화젤로 고해상도 3차원 구조를 제작하여 높은 생체모사도의 체외 세포배양모델을 제작할 수 있어, 미세혈관 네트워크 조립, 유방암 미세환경 구현, 신경 네트워크 형성과 같은 복잡한 체내 미세환경을 재현하는 in vitro 모델에 활용할 수 있다.

剂量分配器

Resumen de: WO2024233888A1

A dose divider for releasable attachment to a plunger rod of a syringe comprises first and second arms. A front portion of the first arm and the front portion of the second arm form a channel therebetween for receiving the plunger rod. A resilient hinge pivotably couples the first arm and the second arm such that the dose divider is reversibly movable between first and second configurations. When the dose divider is in the second configuration, the dose divider is configured to receive the plunger rod in the channel through an opening formed between the front portions of the first and second arms. The channel has a shape configured to receive a specific outer shape of the plunger rod. The front portions of the first and second arms are closer when the dose divider is in the first configuration than when the dose divider is in the second configuration.

药剂包装装置

Nº publicación: CN121443257A 30/01/2026

Solicitante:

株式会社高园

Resumen de: WO2025018078A1

A drug packaging device is provided with a feeding mechanism for feeding a long sheet, a sealing device for sealing the long sheet to form a packaging bag in which a drug is accommodated, and an identifier imparting means. The long sheet is provided with a first surface constituting the inner surface of the packaging bag. The identifier imparting means is configured to apply ink onto the first surface of the long sheet to form an identifier for identifying information regarding the drug to be packaged.