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297
results.
Updated on
02/09/2026 [06:55:00]
Results 25 to 50 of 297
Absstract of: CN122647431A
本发明涉及含有生育酚结构的可电离脂质分子、包含其的脂质纳米颗粒及其用途。具体地，提供一种式(1)所示的含有生育酚及其衍生物结构的可电离脂质分子、包含其的脂质纳米颗粒、其制备方法和用途。与本领域常规使用的可电离脂质分子相比，本发明的式(1)所示的可电离脂质分子所制备得到的脂质纳米颗粒可显著提高核酸的递送效率及表达。
Absstract of: CN122647680A
本发明公开了一种具有液晶性能的嵌段共聚物纳米粒子及其制备方法和应用。所述嵌段共聚物纳米粒子结构式如(1)式所示。本发明通过使用聚合诱导自组装方法中动力学陷阱的特点，获得高固含量且尺寸均一的液晶嵌段共聚物纳米粒子。本发明不仅可获得传统蠕虫状液晶嵌段共聚物胶束，并可获得可调节双折射程度的球形液晶嵌段共聚物胶束。本发明不仅提高了液晶嵌段共聚物纳米粒子的可加工性能，亦通过固含量提供显著提升其大规模制造的可能，在高分子材料和生物医药方面有显著的应用价值。
Absstract of: CN122647726A
本发明属于药物递送载体及化疗类药物领域，具体涉及一种具有GSH/ROS双重响应机制的聚合物及其制备方法和应用、脂质纳米颗粒。该聚合物具有GSH/ROS双重响应机制，其化学结构通式如下所示：A‑R‑B；所述A为具有胆固醇或其衍生物的第一化学结构；所述R为具有GSH响应的第二化学结构；所述B为具有如式I所示的第三化学结构。由此，本发明通过化学结构设计赋予其GSH/ROS双重响应机制，并将其进一步应用于药物递送系统及其在肿瘤协同治疗中，实现了基于氧化还原双响应脂质纳米颗粒的多模态协同治疗策略，为恶性肿瘤治疗提供了具有显著协同增强效应的新技术方案。
Absstract of: CN122643260A
本发明属于纳米药物递送技术领域，具体涉及一种负载CDNF/Rg3仿生脂质纳米颗粒的制备方法和应用。所述方法通过构建过表达ARC的神经干细胞并提取其细胞膜，采用微流控技术制备负载CDNF circRNA和人参皂苷Rg3的ROS响应性脂质纳米颗粒，再经薄膜挤出获得ARC‑RCD‑LNP。该纳米颗粒经鼻腔给药后可进入脑内，借助ARC相关神经元靶向特性提高受损神经元摄取，并在ROS微环境下释放Rg3和CDNF circRNA；CDNF circRNA翻译为CDNF蛋白，抑制α‑Syn聚集，并与Rg3协同发挥抗炎、抗氧化、缓解内质网应激和抗凋亡作用，从而修复受损神经元并改善运动功能障碍。
Absstract of: WO2025030426A1
Provided is a pharmaceutical preparation for treating Bietti's crystalline dystrophy (BCD), comprising a recombinant AAV expressing CYP4V2, sodium chloride, poloxamer, phosphate, and water for injection, and having a pH between 7.0 to 7.6. The pharmaceutical preparation has an excellent virus titer stability, very few AAV aggregates, a high mRNA expression of the target gene after multiple times of freezing and thawing, and/or an excellent high temperature stability. Moreover, the animal experiments in vivo demonstrate that the preparations with the formulations have an excellent property in reducing local inflammatory response of the retina, and further clinical trials demonstrate that the pharmaceutical preparations conform to the relevant technical specifications for safety and effectiveness in the Chinese Pharmacopoeia and the United States Pharmacopoeia (USP).
Absstract of: EP4497433A1
The invention relates to Nano-in-micro (NIM) encapsulated bioactive siRNA dry powder comprising lipid nanoparticles, the lipid nanoparticles comprising from at least an ionizable cationic lipid, a helper lipid, a stealth lipid, and siRNA, wherein the lipid nanoparticles are encapsulated in sugar and/or sugar alcohol, wherein the mass ratio of siRNA to a sugar and/or sugar alcohol is more than 0.10%, especially between 0,90% and 1,30%. The invention also relates to a respective pharmaceutical product containing the dry powder in a sealed volume.
Absstract of: CN120550105A
The invention discloses a DNA vaccine, and the DNA vaccine prepared by taking an H gene and an F gene of a peste des petits ruminants virus strain with a microbial preservation number of CCTCC NO: V202487 as coding genes of immunogens has good immunogenicity and immune protection capability, and has an application prospect.
Absstract of: CN122647415A
本发明涉及含冰片结构的可电离脂质化合物及其制备方法和应用，属于生物医药技术领域。本发明通过对冰片分子C2位羟基进行修饰，引入多胺结构及疏水性尾链，制得一类新型含冰片结构的可电离脂质化合物。该化合物具有以下优势：（i）冰片结构可有效突破皮肤角质层屏障，显著提升经皮吸收效率；（ii）多胺结构在酸性条件下可电离，通过静电吸附作用高效携载核酸药物，有助于增强核酸稳定性并促进溶酶体逃逸；（iii）尾链修饰增强了化合物的脂溶性，赋予其脂质特性，可作为固体脂质纳米粒的制备原料。本发明还提供了所述化合物的制备方法，该类含冰片结构的可电离脂质化合物在核酸药物的经皮递送领域展现出良好的应用前景。
Absstract of: CN122643257A
本发明公开了一种脂质纳米颗粒及其在胞内或体内蛋白质递送中的应用。本发明所述脂质纳米颗粒包括阳离子脂质、可电离脂质、辅脂脂质、胆固醇和聚乙二醇化脂质五种脂质组分；所述脂质纳米颗粒可以实现高效的活细胞内和体内蛋白质递送，且不影响被递送蛋白质的生物学活性；所述脂质纳米颗粒成分安全，具有很好的生物相容性。本发明具有广泛应用前景。
Absstract of: CN122643264A
本发明公开了一种以乳清分离蛋白为载体的鞣花酸纳米颗粒及其制备方法和应用，属于食品加工技术领域。所述制备方法包括如下步骤：将鞣花酸添加至碱性的乳清分离蛋白溶液中，混合均匀后，调节pH至中性；经超声辅助处理后，得到所述鞣花酸纳米颗粒。本发明结合pH驱动方法和超声辅助处理方法，并结合乳清分离蛋白WPI的自身特性，制备了EA包封率高、稳定性强的WPI/EA纳米颗粒，实现了提升EA溶解性、稳定性及生物利用度的效果，为EA的制剂开发与功能活性应用提供了新的制备途径与理论支撑。
Absstract of: CN122643262A
本发明公开了一种纳米晶氟苯尼考颗粒及其制备方法，属于兽药制剂及纳米药物技术领域。所述方法包括：将氟苯尼考溶解于食用级乙醇中制得有机相；将注射用水冷却后加入聚乙二醇‑1000维生素E琥珀酸酯和植酸，制得水相；将两相料液泵入高压微射流对撞反应器中进行连续化混合结晶；产物经减压脱醇、浓缩及干燥，即得类球形纳米晶氟苯尼考颗粒。本发明摒弃了传统有毒溶剂及超声破碎工艺，利用高压微射流的微湍流与植酸的氢键晶面调控作用，一步制备粒径为80～150nm的纳米晶。所得颗粒流动性好、无有毒溶剂残留，25℃下水相溶解度大幅提升，且悬浮稳定性超过120小时。
Absstract of: CN122643432A
本发明公开了一种用于治疗肺部肿瘤的药物组合物及其应用。本发明提供的用于治疗肺部肿瘤的药物组合物包括能够肺部递送CXCL10 mRNA的纳米颗粒和靶向基因修饰免疫效应细胞；所述靶向基因修饰免疫效应细胞为CAR‑T细胞、CAR‑NK细胞、CAR‑M细胞或TCR‑T细胞。本发明证实肺部递送CXCL10 mRNA的纳米颗粒能够增强靶向基因修饰免疫效应细胞（如CAR‑T细胞）的肺部肿瘤浸润及抗肿瘤疗效。本发明不仅为肺部肿瘤免疫治疗提供了具有明确机制支撑的可转化方案，也为拓展mRNA药物在肝外器官的递送与多疾病应用场景提供了重要的技术参考与产业化价值。
Absstract of: WO2025165163A1
The present invention relates to an albumin nanoplatform for boron neutron capture therapy and a composition for boron neutron capture therapy comprising same. The albumin-based nanoplatform according to the present disclosure can effectively deliver boron to specific tumor tissues by simultaneously conjugating a boron compound containing an excessive amount of boron and a targeting molecule as a carrier for specifically targeting tumor tissues via click chemistry functional groups introduced into the albumin surface. In particular, the nanoplatform enables sufficient delivery of boron molecules to target tumor tissues even at doses less than one-tenth of those required by conventional boron neutron capture therapy (BNCT) drugs, and thus can be applied as a composition for boron neutron capture therapy and as an anticancer therapeutic agent.
Absstract of: WO2025157978A1
The present invention relates to ionizable lipids for use in lipid nanoparticles, lipid nanoparticle formulations comprising these ionizable lipids, alone or in combination with other lipids and/or polymers. The lipid nanoparticles formulations may be formulated with nucleic acids for their delivery to target tissues after administration, in particular after parenteral administration such as intravenous, intramuscular, subcutaneous or intratumoral administration.
Absstract of: CN122643427A
一种基于肿瘤抗原表位肽的多靶点DC疫苗及其应用，属于肿瘤免疫治疗技术领域，该疫苗包含hr‑8偶联肽、免疫佐剂和载体，以及免疫记忆增强因子，其中hr‑8偶联肽为hr‑8靶向肽通过化学偶联方式与至少两种不同肿瘤抗原CTL表位肽连接形成的偶联产物，免疫佐剂为TLR9激动剂CpG ODN与TLR3激动剂poly(I:C)的联合佐剂体系，载体为PLGA纳米颗粒，免疫记忆增强因子为IL‑7和/或IL‑15。本发明利用hr‑8肽特异性结合树突状细胞表面DEC‑205受体，实现多靶点抗原的高效协同递送和交叉呈递，联合佐剂与记忆因子显著增强CTL激活并促进长效免疫记忆形成，使得多靶点DC疫苗具有靶向性强、抗原覆盖广、延长无复发生存期的优点。
Absstract of: CN122643425A
本发明公开了RNA及包含其的四价流感疫苗。具体地公开了免疫原性组合物，其包括编码流感病毒H1N1、H3N2、H5N1和H7N9的HA蛋白的四种RNA分子。将该免疫原性组合物包裹在可离子化脂质纳米颗粒中得到mRNA疫苗。本发明的mRNA疫苗具有良好的免疫原性，能够高效表达，可在体内实现稳定安全的表达和有效激活免疫反应，免疫的小鼠可以在体内引起良好的体液免疫，并且有很好的保护作用。本发明的mRNA疫苗作为一种通用型流感疫苗，可提供针对流感病毒的更广泛的保护，具有良好的实际应用价值。
Absstract of: WO2025043179A1
In some aspects, the present disclosure provides methods for generating CAR T cells in situ. The present disclosure provides lipid nanoparticles that selectively target a spleen cell, in particular, a lymphocyte such as a T cell. The lipid nanoparticle provided herein contain a five component composition that includes a permanently anionic lipid giving the lipid nanoparticle an apparent pKa of less than 6.
Absstract of: US20260248969A1
0000 The disclosure relates to multimers of Glypican-3 (GPC3)-, CD44-, and Epithelial cell adhesion molecule (EpCAM)-specific peptides and the use thereof to detect and treat epithelial cell-derived cancers such as hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), breast cancer, colon cancer, gastric cancer, ovarian cancer, cervical cancer, and basal cell carcinoma of the skin. The disclosure also relates to methods to monitor the therapeutic response of treated patients using the peptide multimers.
Absstract of: US20260248903A1
0000 Some aspects of the disclosure relate to vaccines (e.g., RNA vaccines (e.g., mRNA vaccines)) for seasonal influenza viruses as well as methods of using the vaccines. Also described are combination vaccines (e.g., RNA vaccines (e.g., mRNA vaccines)) for seasonal influenza viruses and other respiratory viruses (e.g., respiratory syncytial viruses and coronaviruses), as well as methods of using the vaccines.
Absstract of: US20260248726A1
Disclosed herein are a new type of advanced microparticles for delivery of an active substance. The microparticles exhibit a complex and porous bulk morphology composed of one or more layers of electrospun nanofibrous materials and/or compounds.
Absstract of: US20260248905A1
0000 The invention relates to a fusion protein encoding a polypeptide based on the minimal region of the Orthoreovirus muNS protein capable of forming microspheres and/or nanospheres, modified to permit the addition of polypeptides at the C-terminal.
Absstract of: US20260249292A1
0000 A microfluidic chip (1,100) microfluidic chip (1,100) comprising at least two inlets (2,4,4a -4j ) that meet at a junction (5,5a,5b ) that is in fluid communication with a proximal end (3) of a channel (8,8a,8b,8c ) thereof and an outlet (6) that is in fluid communication with a distal end (7) of the channel (8), wherein the channel (8,8a,8b,8c ) comprises either a plurality of spaced-apart baffle structures (10) continuous with an inner wall (12) of the channel (8, 8a,8b,8c ) or a least one aerofoil-shaped baffle structure (14), or a combination thereof, and forms a microchannel (9) in the channel (8,8a,8b,8c ) adapted to accommodate a fluid.
Absstract of: US20260248734A1
Provided herein is a population of protocells comprising a lipid bi- or multi-layer, mesoporous silica nanoparticles (MSNPs), a cargo, and optionally a targeting ligand and methods of using the same.
Absstract of: WO2026177695A1
The invention relates to a method for the separation, purification, and industrial-scale production of exosomes from plant raw materials for use both as active and/or auxiliary substances in the food, cosmetic, and pharmaceutical industries and in scientific research conducted in the fields of molecular biology, biotechnology, food, agriculture, genetics, and medicine; and additionally for obtaining plant exosomes and purified and concentrated plant extracts while preserving their biological activity and without leaving chemical residues, characterized in that it comprises the process steps of: preparing the plant raw material by drying and grinding plant raw materials into powder form; performing filtration of the mixture of distilled water and plant raw material to remove coarse particles; performing low-speed centrifugation to allow the particles in the solution to settle and to achieve solid–liquid separation; cooling the mixture; performing a second filtration to remove remaining particles from the cooled and rested liquid; applying evaporation to remove excess water; performing ultrafiltration to remove impurity-forming particles; and performing homogenization to ensure uniform distribution of exosomes in the solution.
Nº publicación: US20260248823A1 27/08/2026
Applicant:
TREMBLAY MARIO [US]
TREMBLAY MARIO
Absstract of: US20260248823A1
The invention relates generally to beverage compositions comprising cryogenically produced cannabinoid nanoparticles using cannabinoids made from hemp, and processes for making the same.
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