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77
results.
Updated on
14/07/2026 [08:04:00]
Results 50 to 75 of 77
Absstract of: CN121950481A
The invention relates to the technical field of biomedicine detection, and discloses a biomedicine-based salmonella detection instrument and method for livestock and poultry breeding, the biomedicine-based salmonella detection instrument comprises a detection table and an electron microscope mounted at the upper end of the middle part of the detection table, a conveying assembly is arranged at the upper end of the detection table, and the conveying assembly is used for continuously feeding a culture dish; and the conveying assembly comprises two groups of rotating rods connected with the detection table. According to the salmonella detection instrument and method for livestock and poultry breeding based on biomedicine, stable power is provided for the conveying assembly through the first motor, and continuous and automatic conveying of culture dishes is achieved in cooperation with transmission of a synchronous belt wheel and a feeding belt; the feeding assembly synchronously completes accurate feeding of single culture dishes through the power of the conveying assembly by means of linkage of a driving belt wheel, a driven belt wheel and a transmission belt, a power source does not need to be additionally arranged, the structure is simplified, and meanwhile cooperation and consistency of the feeding rhythm and the conveying rhythm are achieved; and the detection requirements of large-batch salmonella in large-scale livestock and poultry breeding are effectively met.
Absstract of: WO2026089256A1
The present invention relates to an antibacterial composition against pathogenic bacteria, the composition comprising streptococcus salivarius g7 and lactobacillus plantarum gspe05, and specifically, exhibits high antibacterial activity against one or more bacteria selected from the group consisting of Bacillus cereus, Listeria monocytogenes, Salmonella typhimurium, Streptococcus mutans, Porphyromonas gingivalis, and Moraxella catarrhalis, and thus can contribute to the improvement of intestinal diseases, oral diseases, and respiratory diseases caused by these pathogenic strains.
Absstract of: WO2026087662A1
The present invention relates to a combination therapy against pathogenic bacteria in the gut, wherein a bacteriophage against the capsule of the pathogenic bacterium is combined with a vaccination against a bacterial antigen which is normally masked by the capsule.
Absstract of: US20260117162A1
0000 The present disclosure relates to a food poisoning bacteria detection sensor. According to an embodiment, it is possible to provide the food poisoning bacteria detection sensor including: a substrate part; a liquid crystal part that is formed on the substrate part and is composed of a micro partition wall partitioning a unit pixel and a liquid crystal structure layer disposed inside the partitioned unit pixel; and an accommodating part that accommodates the substrate part and the liquid crystal part and includes an aqueous solution.
Absstract of: WO2026087718A1
The present invention, in embodiments, relates to a multivalent vaccine comprising a combination of two or more different monovalent Shigella oligosaccharide protein conjugates and an adjuvant. One of the vaccine components can be a Shigella sonnei oligosaccharide- protein conjugate and the other three can be Shigella flexneri oligosaccharide-protein conjugates, specifically, S. flexneri 2a, S. flexneri 3a and S. flexneri 6, respectively. All conjugates feature sOS components acting as surrogates of the heterogeneous Shigella surface polysaccharide antigens characteristic of each one of the selected Shigella serotypes. The multivalent vaccine of the present invention is made for the prevention and/or treatment of disease caused by Shigella, in particular S. sonnei and S. flexneri.
Absstract of: CN121931058A
The invention discloses a salmonella virulent bacteriophage vBSalPNW15 and application thereof, the bacteriophage is separated from farm sewage, belongs to a long-tail bacteriophage family, has a regular icosahedron head and a long-tail structure, and keeps stable under the conditions that the pH is 4-13 and the temperature is 40-60 DEG C. Genomic analysis shows that the kit does not contain virulence genes and drug-resistant genes and is good in safety. The bacteriophage and cinnamyl aldehyde are combined to be used for preventing and treating salmonella infection, both the bacteriophage and cinnamyl aldehyde show a remarkable synergistic bacteriostatic effect (FICI = 0.5) in vitro and in vivo, and the bacteriophage and cinnamyl aldehyde can effectively inhibit growth of multi-drug-resistant salmonella, remove biological membranes, relieve tissue pathological damage and remarkably improve the survival rate of chicks. The invention provides a safe and efficient antibiotic replacement scheme for preventing and treating salmonella infection, and is suitable for the fields of livestock and poultry breeding and food safety.
Absstract of: CN121930997A
The invention discloses application of pseudomonas in treatment and/or prevention of Alzheimer's disease, and belongs to the technical field of microorganisms. The invention provides pseudomonas salmonella E14-1 for treating and/or preventing Alzheimer's disease, and the pseudomonas salmonella E14-1 can improve the autophagy level of nematodes and the unfolded protein reaction of endoplasmic reticulum, can reduce the latency period of AD mouse water maze, and can increase the number of platform crossing times. The invention further provides a composition for treating and/or preventing the Alzheimer's disease, a microbial agent and application. The composition and the microbial agent can effectively relieve the symptoms of the Alzheimer's disease.
Absstract of: CN121930141A
The invention belongs to the field of medicinal chemistry, and discloses an aromatic pleuromutilin derivative with an antibacterial effect as well as a preparation method and application of the aromatic pleuromutilin derivative. The pleuromutilin is structurally modified, aromatic group modification is further increased through a reductive amination method after mercaptoethylamine is introduced into a C-14 side chain, and the structural formula of the pleuromutilin is shown in the specification. Research on an antibacterial mechanism finds that the series of derivatives can effectively interfere with expression of bacterial protein and show unique and excellent antibacterial activity, and the pleuromutilin can be applied to preparation of antibacterial agents. Compared with pleuromutilin in the prior art, most of the pleuromutilin compounds have antibacterial activity on staphylococcus aureus, escherichia coli, salmonella, micrococcus luteus and enterococcus faecalis which are common in in-vitro clinical application, hardly generate drug resistance, have stable safety and are expected to be further optimized into lead compounds of novel antibiotics.
Absstract of: CN121931266A
The invention provides a primer probe combination, a kit, a nucleic acid detection method and application, and relates to the technical field of biochemical detection. The primer probe combination comprises a first primer pair and a first probe, wherein the first primer pair and the first probe are used for specifically amplifying pseudomonas aeruginosa; the second primer pair and the second probe are used for specifically amplifying enterococcus; the third primer pair and the third probe are used for specifically amplifying staphylococcus aureus; the fourth primer pair and the fourth probe are used for specifically amplifying the salmonella enterica. According to the primer and probe combination, a specific nucleotide sequence is utilized, efficient and accurate recognition of pseudomonas aeruginosa, enterococcus, staphylococcus aureus and salmonella enterococcus is achieved in a complex intestinal environment, and non-specific interference is effectively avoided; meanwhile, synchronous quantitative detection of four pathogens is supported, the detection efficiency is remarkably improved, and an accurate and sensitive detection means is provided for rapid clinical evaluation of flora conditions.
Absstract of: CN121930983A
The invention relates to the technical field of aquaculture microorganisms, in particular to enterococcus faecalis, low-temperature probiotic compound bacteria as well as a preparation method and application of the enterococcus faecalis and the low-temperature probiotic compound bacteria. The low-temperature probiotics used in the invention can keep good growth ability and functional activity in a low-temperature environment. The low-temperature probiotic compound bacteria are added into the feed for feeding, so that the intestinal health of cultured objects in a low-temperature culture environment can be effectively improved, and the abundance of pathogenic bacteria such as vibrio, salmonella and edwardsiella can be effectively reduced. The probiotic compound bacteria can effectively increase the protein content in the cultured objects, and compared with cultured objects without probiotics, the protein content in fish meat of the cultured objects can be increased by 8.4% when the cultured objects are continuously fed with the probiotic compound bacteria for 40 days.
Absstract of: CN121914985A
The invention discloses a cocktail preparation based on duck-origin salmonella adaptive evolution bacteriophage and application of the cocktail preparation, and belongs to the technical field of biological medicine. The cocktail preparation consists of a phage phi ST 705 with the preservation number of CCTCC (China Center for Type Culture Collection) NO: M 2025836, a phage phi R2 with the preservation number of CCTCC NO: M 2025837 and a phage phi R1-1-1 with the preservation number of CCTCC NO: M 2025838. The bacteriophage phi ST 705 is separated and purified from sewage of a farm, and the host bacterium is salmonella ST 705; the bacteriophage phi R2 and the bacteriophage phi R1-1-1 correspond to bacteriophages separated from the salmonella ST 705 in an adaptive evolution strain under the continuous selection pressure of the bacteriophage phi ST 705. The cracking capacity and the host spectrum of the cocktail preparation are remarkably expanded, and the resistant mutation rate of salmonella ST 705 can be effectively reduced.
Absstract of: CN121915177A
The invention belongs to the technical field of microbiological detection, and particularly relates to a primer and a method for detecting salmonella and a drug-resistant gene thereof and application of the primer and the method. The gene of the salmonella is invA, and the drug resistance genes are blaCTX-M, blaNDM-1, blaTEM-1 and blaOXA; the gene of the salmonella is invA, and the drug resistance genes of the salmonella are blaCTX-M, blaNDM-1, blaTEM-1 and blaOXA; the primers comprise inner primers and outer primers of invA, blaCTX-M, blaNDM-1, blaTEM-1 and blaOXA, a primer group is designed according to conserved regions of a salmonella invA gene and part of beta-lactam drug-resistant genes blaNDM-1, blaTEM-1, blaOXA and blaCTX-M, a detection method of SYBR-LAMP and HNB-LAMP technologies is established, and screening of part of beta-lactam drug-resistant genes carried by animal-derived pathogenic strains is realized.
Absstract of: CN121914217A
The invention belongs to the field of biological medicine, and relates to broad-spectrum antibacterial peptide derived from periplaneta americana and anti-tumor application of the broad-spectrum antibacterial peptide. The PA-1 and the PA-2 are both novel alpha-spiral cationic peptides and show remarkable inhibitory activity on pseudomonas aeruginosa, salmonella typhimurium, staphylococcus aureus, staphylococcus epidermidis and carbapenem-resistant acinetobacter baumannii, and the minimum inhibitory concentration on the carbapenem-resistant acinetobacter baumannii reaches 11 mu mol/L. In addition, PA-1 and PA-2 can also obviously inhibit the growth of human colon adenocarcinoma cells SW480, cervical cancer cells Hela and gastric cancer cells HGC-27, and show better anti-tumor potential. And the PA-1 and the PA-2 have good thermal stability, pH stability, salt stability and enzyme stability. The two novel active peptides PA-1 and PA-2 provided by the invention show relatively high medicinal values in the antibacterial and anti-tumor fields, and particularly provide a new choice for clinical treatment of carbapenem-resistant acinetobacter baumannii infection.
Absstract of: CN121914230A
The invention discloses bacteriocin AM12LCIr as well as a preparation method and application of the bacteriocin AM12LCIr. The invention provides a bacteriocin AM12LCIr, the coding sequence of the bacteriocin AM12LCIr is composed of 46 amino acids, the relative molecular weight is 5067.73 Da, homology analysis shows that the bacteriocin AM12LCIr has the highest homology with class II bacteriocin LCI bacteriocin, but the AM12LCIr and LCI have obvious differences in structure and physicochemical properties, and the bacteriocin AM12LCIr belongs to a novel bacteriocin. According to the present invention, the bacteriocin AM12LCIr is subjected to heterologous expression, and the prepared recombinant protein has good inhibition effect on a variety of bacteria, can inhibit Escherichia coli, Listeria monocytogenes, Enterobacter aerogenes, Salmonella paratyphi B, Staphylococcus aureus and Bacillus cereus, has broad-spectrum antibacterial activity, can be used for preparing more antibacterial products, and has broad application prospects. The invention has important significance for clinically preventing and treating a plurality of pathogenic bacteria including escherichia coli.
Absstract of: CN121914893A
The invention relates to a preparation method of a biological agent synergistically produced by bacillus and lactobacillus plantarum, the biological agent and application, and relates to the technical field of bacteriocin preparation. The liquid culture medium contains yeast extract powder and glucose obtained by performing differential temperature asynchronous enzymolysis on starch slurry; s2, uniformly spraying the submerged fermentation liquid obtained in the step S1 on the surface layer of a solid fermentation culture medium within the thickness of 0.5-1 mm for primary fermentation, inoculating lactobacillus plantarum FJS003 into the surface layer of the solid fermentation culture medium within the thickness of 2-3 mm for secondary fermentation after the primary fermentation is finished, and obtaining the production biological agent after the secondary fermentation is finished. The prepared biological agent can effectively inhibit the growth speed of escherichia coli, salmonella and staphylococcus aureus, and meanwhile can effectively degrade aflatoxin B1 and the content of lead, arsenic, mercury and cadmium.
Absstract of: WO2026084839A1
The present disclosure provides a Salmonella therapeutic delivery system having a modified surface for evading the host immune system, and methods of use thereof.
Absstract of: WO2026085295A1
Provided herein are kits, compositions, systems, and methods for treating a subject with a tumor with kynurenine responsive and degrading bacteria (e.g., such that the bacteria reduces or eliminates the tumor). In certain embodiments, the kynurenine responsive bacteria comprise one or more nucleic acid sequences encoding: i) a kynurenine transcriptional regulator protein, ii) a kynurenine transporter protein, iii) a kynureninase (KynU) protein, and iv) at least one protein important or essential for growth of the bacteria expression of which is linked to a kynurenine responsive promoter (e.g., where the corresponding gene(s) has been deactivated or knocked out in the genome of the bacteria).
Absstract of: CN121896139A
本发明属于兽医生物制品领域，具体涉及一株驴源马流产沙门菌spiC基因缺失株YZUSAL01ΔspiC及其构建方法和应用。本发明的基因缺失株已保藏于中国典型培养物保藏中心，保藏编号为CCTCC NO:M 20252392。该缺失株是利用λ‑Red同源重组技术，将马流产沙门菌的spiC基因敲除后获得的。本发明制备的基因缺失株毒力显著下降，具有良好的安全性。攻毒保护试验表明该菌株对小鼠的攻毒免疫保护效果良好，可诱导高效的体液免疫。本发明为预防马流产沙门菌感染提供了安全、保护效力高的减毒活疫苗奠定基础。
Absstract of: CN121892129A
The invention discloses a bimetallic nano-enzyme as well as a preparation method and application thereof, and relates to the technical field of biological detection. The bimetallic nano-enzyme is a DNA-Ag/Pt bimetallic nano-enzyme material prepared on the basis of a specific DNA template sequence or containing the specific DNA template sequence, and can be combined with a double-emission ratio type silver nano-cluster to be used for double-signal detection of vibrio parahaemolyticus. The bimetallic nano-enzyme has peroxidase-like activity, the enzyme activity efficiency is adjustable, and the bimetallic nano-enzyme can be used for double-signal detection of vibrio parahaemolyticus. Compared with the prior art, the color development absorbance of the bimetallic nano-enzyme provided by the invention is improved by about 15%, the lowest detection limit of a colorimetric detection method is 10 CFU/mL, and the lowest detection limit of a fluorescence detection method is 1 CFU/mL; the method has no cross reaction on staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, salmonella, vibrio vulnificus and the like, and is suitable for on-site rapid screening, visual interpretation and semi-quantitative detection of scenes such as water samples and marine products.
Absstract of: CN121891418A
The invention relates to the field of microorganisms, and discloses application and a method of aspergillus cristatus in preparation of a medicine for treating and/or preventing bacterial infection, and the preservation number of the aspergillus cristatus is CGMCC No.41727. The aspergillus cristatus provided by the invention has an inhibition effect on streptococcus mutans, escherichia coli, staphylococcus aureus and salmonella typhimurium, can secrete various active enzymes, and can relieve the symptoms of bacterial infection, including inhibition of expression of proinflammatory factors, promotion of expression of anti-inflammatory factors and reduction of the number of neutrophils; the aspergillus cristatus provided by the invention can also relieve the symptoms of colitis. The aspergillus cristatus provided by the invention has an application prospect in preparation of drugs for treating and/or preventing bacterial infection.
Absstract of: CN121868347A
The invention belongs to the technical field of biology, discloses a culture supernatant of Brawler's bacteria and application, a preparation method and a medicine of a metabolite of the culture supernatant, and discloses application of the culture supernatant of the Brawler's bacteria to preparation of an anti-inflammatory medicine. According to the application, a chicken infected with salmonella is drenched with a Brawler's metabolite in advance, and tests show that the Brawler's metabolite not only can reduce the death rate of the chicken infected with salmonella, but also has obvious inhibition capability on inflammations of multiple organs of the whole body including intestinal tracts, spleen and the like.
Absstract of: CN121873260A
The invention relates to an antibacterial peptide, the amino acid sequence of the antibacterial peptide is as shown in SEQ ID NO: 2, or a polypeptide which is obtained by substituting, deleting or adding one or more amino acids to the amino acid sequence as shown in SEQ ID NO: 2 and has antibacterial activity for escherichia coli, staphylococcus aureus and salmonella. The antibacterial peptide disclosed by the invention has a remarkable inhibition effect on main pathogenic bacteria such as escherichia coli, salmonella, staphylococcus aureus and drug-resistant strains thereof in animal husbandry, and is wide in antibacterial spectrum and high in activity; the feed additive has excellent thermal stability and acid resistance, can tolerate feed granulation high temperature and gastric acid degradation, and ensures effective effects of intestinal tracts; the hemolytic activity is low, and the biological safety is high; the expression quantity of a pichia pastoris fermentation tank is greatly improved, the production cost is remarkably reduced, and the economical requirement of large-scale feed addition is met.
Absstract of: CN121874062A
The invention belongs to the technical field of microorganisms, and particularly relates to lactic acid bacteria and application thereof. The bacterial strain is Ligilobacillus sativus SunLab-GHL01 (L.sativus GHL01 for short), is separated from lungs of high-production-performance Ailijiai broiler chickens and is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number of the bacterial strain is CCTCC NO: M 20251725. The invention further discloses a preparation method of the high-production-performance Ailijiai broiler chicken with high-production-performance Ailijiai broiler chicken with high-production-performance Ailijiai broiler chicken with high-production-performance Ailijiai broiler chicken. Through morphology, physiology and biochemistry, 16S rRNA sequence identification and whole genome sequencing analysis, the taxonomic status and functional characteristics of the 16S rRNA are defined. The strain has good acid resistance, cholate resistance and acid production capacity, has broad-spectrum antibacterial activity, and can effectively inhibit pathogenic bacteria such as escherichia coli, pathogenic escherichia coli, salmonella, staphylococcus aureus and pseudomonas aeruginosa. Animal experiments show that the poultry feed conversion rate and the anti-stress capability can be remarkably improved by atomizing the strain. The strain and the application thereof can be used for improving the health condition and the production performa
Absstract of: CN121874020A
The invention provides lactobacillus reuteri MRL1103 and application thereof, and relates to the technical field of microorganisms and mercury adsorption, the preservation number of the lactobacillus reuteri MRL1103 with a mercury adsorption function is CGMCC NO.28840, the lactobacillus reuteri MRL1103 is separated from fresh chicken manure, the lactobacillus reuteri MRL1103 can tolerate a mercury solution with the concentration as high as 100 mg/L, and under the conditions that the pH is 5 and the concentration of the mercury solution is 5 mg/L, the concentration of the mercury solution can reach 100 mg/L, and the concentration of the mercury solution can reach 100 mg/L; the adsorption rate of the lactobacillus reuteri MRL1103 on mercury in a mercury solution reaches 95% or above, and the lactobacillus reuteri MRL1103 has an inhibition effect on escherichia coli, staphylococcus aureus, salmonella enteritidis, salmonella pullorum or salmonella typhimurium. The lactobacillus reuteri MRL1103 can be used for removing a mercury metal element in a matrix, and the matrix can be mercury-containing soil, a feed or a culture medium.
Nº publicación: WO2026080385A1 16/04/2026
Applicant:
UNIV COLORADO REGENTS [US]
BENAROYA RES INSTITUTE AT VIRGINIA MASON [US]
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON
Absstract of: WO2026080385A1
Methods for the detection of subjects at risk of developing rheumatoid arthritis, and subjects having early rheumatoid arthritis thus allowing for early intervention. Compositions for inducing immune tolerance in a subject thus treating or slowing progression of RA. Kits useful in the diagnosis of RA.
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