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93
results.
Updated on
29/08/2025 [07:14:00]
Results 50 to 75 of 93
Absstract of: CN120174154A
The invention relates to the technical field of molecular biological detection, in particular to a primer, a probe group and a kit for multiplex nucleic acid mass spectrometry detection of porcine diarrhea pathogens and application. By adopting a matrix-assisted laser desorption/ionization time-of-flight nucleic acid mass spectrometry technology, eight main pathogens such as PEDV, TGEV, PDCoV, PoRV, SADS-CoV, PBoV, HEV and salmonella can be rapidly, sensitively and specifically detected at the same time. By designing the specific primer and the unexpanded probe and combining multiple PCR amplification and mass spectrometry, the method realizes high-throughput and multi-pathogen simultaneous detection. Experimental results show that the method has high sensitivity and high specificity, has no false positive reaction, and shows 100% repeatability in 60 repeated experiments. Compared with a qPCR method, the detection consistency is as high as 96.2%. The method has the advantages of being easy and convenient to operate, high in detection speed and high in adaptability, can be widely applied to efficient monitoring of porcine diarrhea pathogens, and provides important technical support for early diagnosis, prevention and control of porcine diseases.
Absstract of: CN120169352A
The invention discloses a preparation method of Au (at) Au (at) Ag/Pt/M NPs and application of the Au (at) Au (at) Ag/Pt/M NPs in klebsiella pneumoniae detection, and belongs to the technical field of analysis and detection. The invention particularly relates to development of a signal probe and combination and assembly of the signal probe and lateral flow immunochromatography (LFIA) for klebsiella pneumoniae detection. Au (at) Au (at) Ag/Pt/MNPs is a multi-element noble metal nanoparticle with plasma resonance property, peroxidase-like activity and light stability, shows strong detection potential in three modes of colorimetric (CM), catalytic colorimetric (CL) and surface enhanced Raman scattering (SERS), and is loaded into LFIA to construct a multi-mode LFIA (CM/CL/SERS-LFIA). The kit is expected to be used for direct multimode detection of klebsiella pneumoniae in clinical sputum samples, and a new early detection strategy is provided for respiratory tract infection diseases such as klebsiella pneumoniae.
Absstract of: CN120173819A
The invention relates to the field of microorganisms, in particular to bacillus subtilis, a fungicide and application of the fungicide. The invention discloses a bacillus subtilis strain, which is classified and named as bacillus subtilis, has a strain number of GXGD-YZ-2483, is preserved in Guangdong Microbial Culture Collection Center on March 13, 2025, and has a preservation number of GDMCC No: 66014. The bacillus subtilis can tolerate the high temperature of 70-90 DEG C, has excellent self-heat production performance, and can produce lignin degrading enzymes (laccase, manganese peroxidase and/or lignin peroxidase) and inhibit the growth of pathogenic bacteria (escherichia coli, salmonella, clostridium perfringens and/or aspergillus flavus). When the bacillus subtilis or the microbial inoculum prepared from the bacillus subtilis is used for biologically composting organic wastes, a lignin barrier can be efficiently cracked by secreting a lignin degrading enzyme system, lignin degradation, nitrogen retention and pathogenic bacteria inactivation can be synchronously realized by virtue of high temperature resistance, self-heat production characteristics and enzyme activity stability, the composting period is shortened, and the yield of the organic wastes is improved. The humification quality is obviously improved.
Absstract of: CN120173781A
The invention belongs to the technical field of microorganisms, and relates to a selenium-rich bacillus velezensis with high tolerance and application of the selenium-rich bacillus velezensis. The invention relates to a selenium-rich bacillus velezensis 915-1 with strong tolerance, which is preserved in Guangdong Microbial Culture Collection Center, and the preservation number is (GDMCC No: 64021). The bacillus velezensis 915-1 can effectively inhibit growth of escherichia coli, salmonella and staphylococcus aureus after inoculation as first inoculation culture bacteria, and can be used as probiotics or drugs for colonization in intestinal tracts to play roles in inhibiting pathogenic bacteria and benefiting life. The bacillus velezensis is applied to production of organic selenium. The bacillus velezensis can absorb, convert and utilize sodium selenite, the sodium selenite is enriched into thalli to be converted into organic selenium, the content of the organic selenium is increased along with increase of the number of cells, and the bacillus velezensis can be used for production and preparation of the organic selenium.
Absstract of: CN120173891A
The invention discloses a salmonella bacteriophage cocktail and application thereof, and belongs to the technical field of bioengineering, the salmonella bacteriophage cocktail is characterized by comprising a salmonella bacteriophage vBSenMP9, a salmonella bacteriophage vBSalSPS87 and a salmonella bacteriophage vBSalSPMY153, and the salmonella bacteriophage vBSalSPMY153 is prepared from salmonella bacteriophage vBSenMP9, salmonella bacteriophage The salmonella bacteriophage vBSenMP9 is preserved in the China Center for Type Culture Collection, and the preservation number of the salmonella bacteriophage vBSenMP9 is CCTCC M 20231900; the salmonella bacteriophage vBSalSPS87 is preserved in the China Center for Type Culture Collection, and the preservation number of the salmonella bacteriophage vBSalSPS87 is CCTCC M 20242948; the salmonella bacteriophage vBSalSPMY153 is preserved in the China Center for Type Culture Collection, and the preservation number of the salmonella bacteriophage vBSalSPMY153 is CCTCC M 20242949. The salmonella bacteriophage cocktail has a wide splitting spectrum for salmonella, and genes related to lyogen, drug resistance and toxicity are not found in each salmonella bacteriophage genome, so that the salmonella bacteriophage cocktail is safe when being applied to research and development of medicines and sterilization products.
Absstract of: CN120177776A
The invention relates to the technical field of bacterium detection, in particular to a colorimetric-Raman coding immunochromatography test strip based on a 3D film-shaped SERS probe and a multi-bacterium detection method thereof. According to the technical scheme, the kit comprises a sample pad, a nitrocellulose membrane, a water absorption pad, a 3D membrane-like SERS probe and an operation buffer solution. According to the present invention, the immunochromatography of the 3D film-like probe is provided, the MoDAu-coated Ag SERS nano-film is adopted as the probe in the system, such that the pathogenic bacteria can be highly specifically recognized and captured, the immune complex fluidity can be increased, the rapid quantitative detection of the three pathogenic bacteria can be achieved, and the flexible 3D film-like SERS probe capable of enhancing the colorimetric ability and the SERS activity and highly specifically capturing the pathogenic bacteria can be prepared; by combining with an antibody-modified ICA test strip, rapid, simultaneous and quantitative determination of various pathogenic bacteria is realized.
Absstract of: US2025195631A1
To make an immunotherapy that is effective for a larger group of cancer patients, Salmonella have been genetically engineered to deliver proteins from prior vaccines into the cytoplasm of tumor cells.
Absstract of: US2025195635A1
A method of generating a Salmonella free egg is disclosed. The method includes administering a vaccination to a poultry animal that is less than one year old. The method further includes boosting the vaccination of the poultry animal when the poultry animal is between about 50 weeks old and about 60 weeks old, the boosting comprising administering killed virus if the poultry animal molted subsequent to the vaccination, and the boosting comprising administering live virus if the poultry animal did not molt subsequent to the vaccination at the time of boosting.
Absstract of: US2025197951A1
This disclosure relates to methods of isolating rare or non-dominant serotypes of Salmonella species from a sample. The disclosure further relates to the isolation of non-dominant serotypes of Salmonella in a sample related to one or more products for human or animal consumption.
Absstract of: AU2023323947A1
The invention is directed to immunogenic compositions and method of treatment comprising a peptide or nucleic acid that encodes the peptide that induces an immune response in a mammal that is protective against infection by one or more pathogens. The peptide sequence contains multiple epitopes, wherein at least one epitope is a composite epitope which is a combination of two or more conserved epitopes of the pathogen wherein the amino acid sequence of the composite is not an amino acid sequence of the pathogen. In addition, the invention is directed to vaccines comprising the peptide or nucleic acid that encodes the peptide for treating and preventing an infection in mammals such as animals and humans.
Absstract of: US2025025552A1
The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.
Absstract of: CN120158533A
The invention provides a method for detecting salmonella enteritidis, which comprises the following steps of: 1, expressing a nano antibody for resisting salmonella enteritidis FliC by using escherichia coli, and verifying the nano antibody; step 2, preparing immunomagnetic beads for resisting FliC protein, and verifying the immunomagnetic beads; step 3, carrying out specific enrichment on the target bacteria; 4, performing rapid splitting decomposition to release nucleic acid; step 5, carrying out isothermal amplification on the target DNA fragment; and step 6, CRISPR/Cas12a mediated signal amplification and detection are carried out. The kit has the effects of ultra-fast detection, high sensitivity, high specificity, portability, easiness in operation, no need of bacterial culture and the like.
Absstract of: CN120158403A
The invention provides lactobacillus pentosus YN-02, a product prepared from the lactobacillus pentosus YN-02 and application of the lactobacillus pentosus YN-02, and belongs to the technical field of biological medicine, the lactobacillus pentosus YN-02 is preserved in China Center for Type Culture Collection on October 22, 2024, and the preservation number is CCTCC NO.M20242300; the gene sequence of 16srRNA (Ribonucleic Acid) of the lactobacillus pentosus YN-02 is as shown in SEQ ID NO. 1. According to the lactobacillus pentosus YN-02, the product prepared from the lactobacillus pentosus YN-02 and the application of the lactobacillus pentosus YN-02, the lactobacillus pentosus YN-02 and the product, the lactobacillus pentosus YN-02, the product and the application have a remarkable effect in the aspect of resisting infection of listeria monocytogenes, salmonella enteritidis, escherichia coli, staphylococcus aureus and salmonella typhimurium.
Absstract of: CN120157916A
The invention relates to the technical field of hydrogel, in particular to a preparation method and application of EGCG-mediated hydrogel, a lysozyme solution is heated under the acidic condition to form lysozyme amyloid fibrils LAFs, EGCG is dissolved in a buffer solution and mixed with the LAFs solution obtained in the step 1 in proportion to form an LAFs-EGCG compound, and the EGCG-mediated hydrogel is prepared. The chitosan CS is dissolved in an acetic acid buffer solution, glutaraldehyde is added to serve as a cross-linking agent, the mixture is mixed with the LAFs-EGCG compound obtained in the step 2 and stirred, the composite hydrogel is formed, the concentration of EGCG is 0.2-1.0 wt%, the concentration of LAFs is 5 wt%, the concentration of chitosan is 2 wt%, the pH value of the lysozyme solution in the step 1 is 2.0, the heating temperature is 77 DEG C, the heating time is 10 hours, the concentration of EGCG in the step 2 is 0.4-0.8 wt%, and the pH value of the lysozyme solution in the step 2 is 1.5-2.5. In the step 3, the concentration of glutaraldehyde is 2%, the storage modulus G'of the hydrogel is 325-480 Pa, the hardness is 2176.71 g, and the bacteriostasis rate on staphylococcus aureus and salmonella exceeds 95%.
Absstract of: CN120142654A
The invention discloses a method for in-situ detection of drug sensitivity of different types of bacteria in a mixed flora based on metabolic labeling combined with fluorescence in-situ hybridization, and belongs to the technical field of microbiological detection. The activity change condition of all bacteria in a flora under the action of an antibacterial drug is quantified through a D-type amino acid fluorescent probe (FDAA) metabolism labeling method, target bacteria are recognized through a fluorescence in-situ hybridization technology, and the drug sensitivity of the bacteria is detected in a manner of detecting the fluorescence intensity change of the corresponding bacteria in combination with a flow cytometry. The method can be used for rapidly and effectively performing species identification on various pathogenic bacteria in a mixed flora sample at the flora level and simultaneously determining and evaluating the antibacterial drug sensitivity of the pathogenic bacteria. The method is high in detection sensitivity, the minimum inhibitory concentration (MIC) of low-abundance target bacteria (larger than or equal to 0.5%) in a flora system can be accurately measured, and antibacterial spectrums of almost all bacteria in the complex flora system are established; the kit can be used for drug sensitivity detection of aerobic bacteria and anaerobic bacteria, can also be used for antibiotic sensitivity determination of flora level of microorganisms which cannot be cultured
Absstract of: CN120137814A
The invention belongs to the technical field of biology, and particularly relates to lactobacillus gasseri LTG1323 and application thereof. The lactobacillus gasseri provided by the invention has relatively strong enrichment ability and acid production ability, has relatively strong inhibition ability on escherichia coli, staphylococcus aureus, bacillus cereus, shigella flexneri and salmonella typhimurium, has strong colonization ability in human intestinal tracts, can regulate and optimize a microenvironment, is sensitive to six common antibiotics, and can be used for preparing a feed additive. And the prepared freeze-dried powder has the characteristics of high viable count, long shelf life and the like.
Absstract of: CN120137852A
The invention relates to a bifidobacterium animalis subsp. Lactis YYSJ001 with a blood sugar reducing effect and application of the bifidobacterium animalis subsp. Lactis YYSJ001. The classification name of the strain is bifidobacterium animalis subsp. Lactis, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.33471. The invention further relates to a preparation method of the bifidobacterium animalis subsp. Lactis YYSJ001. The bacterial strain has good artificial gastric juice resistance, artificial intestinal juice resistance and intestinal tract adhesion ability, has an inhibition effect on numerous pathogenic bacteria such as escherichia coli, staphylococcus aureus, salmonella, klebsiella pneumoniae and quail chicken enterococcus, and can stimulate intestinal cells to generate glucagon-like peptide-1, so that the bacterial strain can be applied to preparation of various pathogenic bacteria. Diseases of diabetic mice can be effectively improved, and the compound can be used for preparing products for preventing and treating diabetes or assisting in reducing blood sugar.
Absstract of: CN120137051A
The invention discloses a fusion antibacterial peptide BMAP18-BSN37 and application thereof, and belongs to the technical field of gene engineering. The nucleotide sequence of the fusion antibacterial peptide BMAP18-BSN37 is as shown in SEQ ID NO. 1, and the amino acid sequence of the fusion antibacterial peptide BMAP18-BSN37 is as shown in SEQ ID NO. 2. The fusion antibacterial peptide BMAP18-BSN37 gene is inserted into a pNZ8148 expression vector to construct a recombinant expression vector pUBB, so that protein aggregation or degradation in cells can be avoided, and the survival rate of strains and the stability of protein expression are improved. The method comprises the following steps: transferring a plasmid pUBB into a lactic acid bacteria NZ9000 strain through electrotransformation, and screening a recombinant lactic acid bacteria strain capable of expressing a fusion protein BMAP18-BSN37 to obtain a recombinant strain NZ-BB; the recombinant lactic acid bacteria NZ-BB strain shows a remarkable prevention effect in an animal infection model, and can effectively reduce bacterial colonization and relieve pathological injury; the Salmonella strain has the potential of being used as an animal feed additive, can reduce the use of antibiotics and chemicals, slow down the development of bacterial drug resistance, improve animal immunity and slow down intestinal inflammation caused by salmonella, and provides support for effectively preventing the health of livestock and poult
Absstract of: CN120137870A
The invention discloses a sifA gene knockout attenuated salmonella recombinant engineering bacterium as well as a preparation method and application thereof, and belongs to the technical field of microbial biology. An intracellular vesicle (SCV) of the attenuated salmonella VNP20009 of the engineering bacterium forms a related gene sifA, and the related gene sifA is seamlessly knocked out. The engineering bacterium is named as VNP20009 delta sifA. The invention also discloses a preparation method of the engineering bacterium. The engineering bacterium has the characteristic of keeping the characteristic of specific colonization of a female parent strain VNP20009 in a tumor hypoxic region, and meanwhile, the biotoxicity of the strain is further reduced; meanwhile, the strain has a potential value of becoming a chassis strain for combined synthesis of biological tumor therapy due to relatively weak killing performance and higher intracellular load on immune cells. The invention also provides a construction method of the strain and application of the strain in treatment of mouse entity subcutaneous melanoma.
Absstract of: CN120138182A
The invention discloses a detection method for salmonella based on RPA-CRISPR/Cas12a regulation and control of fluorescence polarization enhancement. The detection method comprises the following steps: performing DNA extraction on a to-be-detected sample, and then mixing the to-be-detected sample with an RPA reagent, a dissolving agent, ddH2O, an upstream primer, a downstream primer and an activating agent to obtain an amplification product; the amplification product is mixed with Exo I enzyme, Exo I buffer and ddH2O for incubation, and a cutting product is obtained; mixing and incubating the cleavage product with water, LbaCas12a, a target sequence crRNA and an r2.1 buffer, so as to obtain a solution to be detected; and detecting the salmonella in the to-be-detected sample according to the fluorescence polarization value of the to-be-detected solution. The salmonella detection method provided by the invention has the advantages of rapidness, simplicity and convenience in operation, high sensitivity and strong specificity, and can efficiently detect salmonella.
Absstract of: CN120131712A
The invention belongs to the field of biological medicines, and provides a composition and a method for treating tumors by using attenuated salmonella and an immune checkpoint inhibitor. The anti-tumor immune response is activated in a mode of combining the attenuated salmonella and the immune checkpoint inhibitor, and the inhibition effect on tumor cells is synergistically improved. The medicine shows an excellent treatment effect on malignant tumors lacking an effective control means at present, and has a wide application prospect.
Absstract of: WO2025122955A1
Provided herein are methods and compositions for treating cancer. One composition includes an engineered bacterial cell comprising: a) a lysis gene or lysis cassette operably linked to an intracellularly induced Salmonella promoter; b) one or more of the bacterial cell genes selected from the group consisting of recA, recB, recF, sbcB, sbcCD, red, sseJ or any combination thereof are knocked out; and c) a nucleic acid sequence coding for an oncolytic virus genome.
Absstract of: WO2024155027A1
The present invention relates to an attenuated Salmonella gallinarum expressing FliC or FliC-hiL2 and use thereof. The Salmonella strain according to the present invention has excellent immune activity and exhibits excellent anti-cancer efficacy, and thus can be used as a therapeutic agent for cancer together with or independently of existing anti-cancer drugs.
Absstract of: CN120118818A
The invention provides a controllable self-destruction engineering bacterium and a preparation method thereof, attenuated salmonella typhimurium is taken as a carrier, plasmid containing PD-1 gene is introduced into the body of the bacterium, and the engineering bacterium VNP-mPD-1 is obtained; the preparation method comprises the following steps: preparing engineering bacteria VNP-mPD-1-N3, enabling the surface of the engineering bacteria to contain an azide group through a glycometabolism method to obtain the engineering bacteria VNP-mPD-1-N3 with the surface containing the azide group, and covalently linking a DBCO modified photosensitizer with the azide group on the surface of the engineering bacteria through a click chemistry method to prepare the controllable self-destruction engineering bacteria VNP-mPD-1-(at) IN. The controllable self-destruction engineering bacterium prepared by the invention is good in biological safety, can generate active oxygen under laser irradiation, and has anti-tumor performance.
Nº publicación: CN120119010A 10/06/2025
Applicant:
FOOD INSPECTION AND TESTING INST OF JIANGXI INSPECTION AND TESTING INST JIANGXI GRAIN QUALITY INSPEC
WUHAN POLYTECHNIC UNIV
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Absstract of: CN120119010A
The invention discloses an LMTIA primer combination for detecting salmonella and application, and relates to the technical field of microbiological detection.The LMTIA primer combination comprises a first primer and a second primer, the sequence of the first primer is shown as SEQ.ID.No.1, and the sequence of the second primer is shown as SEQ.ID.No.2. The invention further discloses a kit for detecting salmonella. Amplification of the target gene of the to-be-detected sample can be completed within 30 min through the first primer, the second primer and a constant-temperature environment, expensive equipment such as a PCR instrument is not needed, the specificity is high, the false positive rate is low, the sensitivity is not worse than that of PCR, and the kit can be used for rapidly detecting salmonella on site.
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