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58
results.
Updated on
21/02/2026 [07:22:00]
Results 50 to 58 of 58
Absstract of: CN121015753A
The invention discloses a dark plum antidiarrheal compound preparation for treating chicken diarrhea and a preparation method thereof. The dark plum antidiarrheal compound preparation is prepared from the following active ingredients: dark plum, schisandra chinensis, radix isatidis and berberis poiretii schneid in a mass ratio of (8-12): (12-16): (12-16): (8-12). The fructus mume antidiarrheal compound preparation for treating chicken diarrhea is low in price, and the cost of the fructus mume antidiarrheal compound preparation is reduced by 50% or above compared with that of currently common Chinese pulsatilla root oral liquid, Chinese pulsatilla root powder, Sihuang antidiarrheal granules, Siwei herba andrographitis powder and other compounds, and even is reduced by 500% or above compared with that of the Chinese pulsatilla root oral liquid/powder. The traditional Chinese medicine composition can completely inhibit characteristic pathological changes of peritonitis, pericarditis, perihepatic inflammation and enteritis caused by pathogenic bacteria of escherichia coli and salmonella by 100%, the cure rate of bacterial diarrhea is 100%, disordered intestinal flora and damaged intestinal villi of infected chickens can be recovered, and the inflammatory response of the infected chickens is remarkably reduced.
Absstract of: CN121022764A
The invention relates to the technical field of biology, in particular to a bacteriophage vBSalPSE29, a bacteriophage vBSalPSE29 preparation and application of the bacteriophage vBSalPSE29 preparation. The invention provides a bacteriophage vBSalPSE29, and the preservation number of the bacteriophage vBSalPSE29 is CGMCC (China General Microbiological Culture Collection Center) No.46499. The bacteriophage vBSalPSE29 is According to the salmonella pullorum bacteriophage provided by the invention, through whole genome sequencing analysis, gene sequences related to lysogenic transformation, antibiotic resistance and virulence factors are not detected in the genome of the salmonella pullorum bacteriophage, so that the biological safety of the bacteriophage for drug development and sterilization product development is ensured from the molecular level, and potential biological risks are effectively avoided.
Absstract of: CN121015906A
The invention relates to the technical field of nano-drug carriers, in particular to a preparation method and application of enzyme-responsive nano-vesicles with pillararene as a carrier, a compound 30 is used as a starting raw material and condensed with a compound 31 under the action of EEDQ to obtain a compound 32, the compound 32 is subjected to Fmoc protection removal through piperidine and diethyl ether precipitation to obtain a compound 33, and the compound 33 is subjected to enzyme-responsive reaction to obtain the enzyme-responsive nano-vesicles with pillararene as the carrier. A compound 33 and a compound 34 react in DMF to obtain a compound 35, the compound 35 is subjected to trifluoroacetic acid deprotection to obtain a compound 36, the compound 36 and a compound 37 react and are subjected to column chromatography separation to obtain a compound 38, the compound 38 and terminal alkyne pillar arene 11 are subjected to 1, 3-dipole addition under the catalysis of Cu I/TBTA to obtain a compound 39, acetyl protecting groups are removed through sodium methoxide to obtain MP5, MP5 is dissolved in deionized water containing 1% of DMSO, dialysis is performed after ultrasonic treatment, and the compound 38 is obtained. The MP5 nano vesicle solves the problem that common antibiotics cannot play a role in intracellular parasitic salmonella, so that infection is difficult to radically treat.
Absstract of: CN121015731A
The invention discloses an extraction method and application of guava functional components for preventing and treating piglet diarrhea. The extraction method comprises the following steps: performing vacuum drying on guava leaves at 45-60 DEG C, and crushing; mixing with an ethanol-water mixed solvent, and carrying out ultrasonic-assisted extraction; filtering the extracting solution, concentrating under reduced pressure, and freeze-drying to obtain the guava leaf extract; according to the scheme, comprehensive prevention and control of bacterial diarrhea are achieved, phenolic compounds in GE directly inhibit growth of ETEC and salmonella, compound enzymes make up the defect that piglet digestive enzymes are insufficient to reduce intestinal burden, and traditional Chinese medicine compounds enhance the intestinal convergence function; the natural plant extract, the traditional Chinese medicine compound and the food-grade enzyme preparation are taken as core components, so that the problems of drug resistance and residue of antibiotics are avoided; ultrasonic-assisted ethanol-water mixed solvent extraction is adopted, and a freeze drying technology is combined, so that the yield of phenolic compounds in GE is increased, the impurity content is reduced, and the raw material cost and the feed palatability influence are reduced.
Absstract of: CN121023055A
The invention discloses an avian salmonella nucleic acid rapid detection method based on a RAA-CRISPR-Cas13a technology and a kit, and belongs to the technical field of biochemistry and molecular biology. On the basis of the designed RAA primer pair and crRNA, the avian salmonella nucleic acid detection based on an RAA-CRISPR-Cas13a enzyme molecular system is established, the system is high in specificity and sensitivity, rapid detection of avian salmonella can be achieved within 30 minutes, the detection sensitivity of a fluorescence method can reach 100 copies/microliter, and the detection sensitivity of a test paper method can reach 102 copies/microliter. In addition, according to the system, expensive test equipment does not need to be operated in a standard professional laboratory, and field detection of clinical samples can be achieved through the portable visual transverse flow test strip.
Absstract of: US2025360189A1
An immunogenic gel compositions for oral administration and methods of immunizing an animal the methods including administering to the animal a therapeutically effective amount of an immunogenic gel composition comprising an antigen of an animal pathogen and a gel composition for oral administration.
Absstract of: WO2025245361A1
The present invention relates to antigen presentation to CD8+ T cells. Systems and methods are provided for efficient presentation of diverse peptide antigens and induction of stimulatory and regulatory CD8+ T cell responses.
Nº publicación: CN121003595A 25/11/2025
Applicant:
JILIN AGRICULTURAL UNIV
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Absstract of: CN121003595A
The invention relates to the field of biological pharmacy, in particular to a bacteriophage microcapsule as well as a preparation method and application thereof. The invention provides a bacteriophage microcapsule. The bacteriophage microcapsule comprises 1-5% (w/v) of sodium alginate, 6-10% (w/v) of gelatin, 1.1-3.3% (w/v) of calcium chloride and bacteriophage. According to the invention, salmonella S.Enterica-29 is taken as a host bacterium, microencapsulation coating is carried out on the bacteriophage vB-SalP-SE29, and the bacteriophage has relatively strong lysis activity on the host bacterium. Three materials of sodium alginate, gelatin and CaCl2 are adopted for microencapsulation coating, and on the basis of a single factor test, an optimal preparation condition is obtained through orthogonal test optimization. The microencapsulated bacteriophage vB-SalP-SE29 has the advantages of reducing inflammatory factor expression, relieving inflammatory response and the like, is expected to become an effective antibiotic replacement therapy, and provides a new thought for research of bacteriophage preparations.
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