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87
results.
Updated on
13/07/2025 [07:15:00]
Results 50 to 75 of 87
Absstract of: CN119923470A
The present invention relates to a modified live attenuated Salmonella strain comprising at least one chromosomal integrated synthetic polynucleotide sequence inserted in a predetermined pseudogenomic position, said sequence comprising at least one defined recombination site for introducing a heterologous polynucleotide sequence encoding a polypeptide, wherein the chromosome integration synthetic polynucleotide sequence is located within at least one genomic site, the genomic site being defined by any one of SEQ ID NO: 1-30 or a sequence having at least 70% identity with any one of SEQ ID NO: 1-30. The invention also relates to vaccine compositions comprising the modified strains and various uses and methods thereof.
Absstract of: CN119913268A
The invention discloses a multiple qPCR (quantitative polymerase chain reaction) detection reagent for detecting neonatal gastrointestinal infection pathogens. The kit comprises specific primers and probes for detecting enterohemorrhagic escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, streptococcus agalactiae, klebsiella pneumoniae, staphylococcus epidermidis, beta hemolytic streptococcus, salmonella, rotavirus and adenovirus. According to the invention, different fluorescently-labeled probes are utilized to add specific primers and probes of multiple pathogens into a reaction system to detect multiple targets at the same time, and the method has the advantages of good specificity, high sensitivity, short detection period, capability of simultaneously detecting multiple pathogens, rapidness, simplicity, convenience and economy; a convenient method is provided for rapid detection of pathogens causing neonatal gastrointestinal infection, and the kit has important significance in epidemiological research, clinical early molecular diagnosis and the like.
Absstract of: CN119913066A
The invention provides a Lactobacillus paracasei, which has a preservation number of CGMCC (China General Microbiological Culture Collection Center) No.32951. The Lactobacillus paracasei has a preservation number of CGMCC No.32951. The Lactobacillus paracasei has a preservation number of CGMCC No.32951. The lactobacillus paracasei ID001 provided by the invention has an inhibition effect on enteropathogenic bacteria such as salmonella, escherichia coli, staphylococcus aureus and the like. The probiotic preparation is obtained through fermentation and the dendrobium officinale extract, and the probiotic preparation has the immunoregulation effect through performance verification and screening.
Absstract of: US2025134980A1
The present disclosure relates to novel immunogenic monovalent and multivalent polysaccharide-protein conjugate vaccine compositions comprising a polysaccharide selected from Salmonella serovar strains S. typhi; S. paratyphi A; S. typhimurium and S. enteritidis and alternative improved methods of polysaccharide fermentation, polysaccharide purification, polysaccharide-protein conjugation and stable formulation. The present disclosure further relates to methods for inducing an immune response in subjects against Salmonella and non-typhi related diseases and/or for reducing or preventing Salmonella typhi and non-typhi related diseases in subjects using the compositions disclosed herein. The vaccine elicits bactericidal antibodies and is useful for prevention of gastroenteritis, enteric and typhoid fever.
Absstract of: WO2025090839A1
Described herein are compositions, methods, and kits for detecting diarrhea causing pathogens from patient, food, or environmental samples. One embodiment described herein is primer pairs and probes for multiplex polymerase chain reaction (PCR) based assays for the detection of gastrointestinal pathogens, such as Adenovirus, Astrovirus, Rotavirus, Norovirus, Sapovirus, Campylobacter species, Clostridium difficile, Enteroaggregative E. coli (EAEC), Enteropathogenic E. coli (EPEC), Enterotoxigenic E. coli (ETEC), Shiga-like toxin-producing E. coli (STEC), Shigella/Enteroinvasive E. coli (EIEC), E. coli O157, Listeria monocytogenes, Plesiomonas shigelloides, Salmonella species, Yersinia enterocolitica, Vibrio species, Cryptosporidium species, Cyclospora cayetanensis, Entamoeba histolytica, Giardia intestinalis, or Giardia lamblia. Other embodiments include methods and kits for detecting gastrointestinal pathogens.
Absstract of: EP4545628A1
The present application relates to a Limosilactobacillus fermentum MSJK0025 from breast milk for adjusting gut microbiota and an application thereof. The Limosilactobacillus fermentum MSJK0025 from breast milk is preserved in China General Microbiological Culture Collection Center, with a preservation number of CGMCC No.26426. The Limosilactobacillus fermentum from breast milk provided in the present application is a new strain separated from the healthy nursing woman, named as "Limosilactobacillus fermentum MSJK0025", having good antibiotics sensitivity, and its property can be stably inherited. It has good resistance to acid, bile salt, and artificial gastric juice and intestinal juice, and fast growth rate and good safety. At the same time, the strain has strong survival capability in the gut, and effectively inhibits pathogenic bacteria in the gut such as Escherichia coli, Staphylococcus aureus, Salmonella typhimurium, and Candida albicans, but does not inhibit the probiotic in the gut such as lactobacillus and bifidobacterium, so the strain has broad application prospect in adjusting the balance of gut microbiota.
Absstract of: CN119901919A
The invention discloses a capture probe, a detection probe, a detection system and a detection method for escherichia coli O157: H7. The capture probe comprises a magnetic bead capture probe containing rich amino groups and a specific detection probe (nano V-MnO2 (at) ZIF-90/Apt) with an escherichia coli O157: H7 aptamer, a detection system combining a capture probe and a detection probe is adopted to capture and recognize escherichia coli O157: H7 in a sample, a Fe3O4 (at) SiO2-NH2-bacteria-V-MnO2 (at) ZIF-90/Apt compound is formed, reaction is started under specific conditions, a colorimetric signal value is determined according to absorbance at 417 nm, or a colorimetric card is adopted for colorimetry, or the temperature difference before and after 808 nm laser irradiation is adopted, quantitative analysis of escherichia coli O157: H7 is performed, and the detection result is accurate. The detection requirements of rapidity and field applicability are met, and the method has application value in the field of food safety detection.
Absstract of: AU2023312737A1
Provided herein are vaccine composition comprising a
Absstract of: CN119899887A
The invention discloses a high-throughput reverse screening method for functional probiotics for preventing salmonella typhimurium, belongs to the technical field of microorganisms, and is a high-throughput reverse screening method based on a plate agglutination test, and the functional probiotics capable of secreting salmonella typhimurium immune analogues can be rapidly and efficiently screened out. The screening efficiency is greatly improved, the screening cost is greatly reduced, and the screened functional probiotics can prevent salmonella typhimurium infection, are safe and non-toxic, have no side reaction, have long immune duration and have important clinical application value; the functional probiotics can be prepared into functional probiotic vaccines or oral products, infection of salmonella typhimurium in clinical breeding is effectively prevented, the death rate of ducks is remarkably reduced, and economic benefits are improved.
Absstract of: CN119899903A
The invention discloses a cdLAMP-based detection kit for simultaneously detecting staphylococcus aureus and salmonella and a detection method thereof, and relates to the field of biological detection.The detection kit comprises a silicon-based nano porous chip, a primer probe combination, 20 mM Tris-HCl, 10 mM KCl, 8 mM MgSO4, 10 mM (NH4) 2SO4, 0.05% Tween-20, a 2.5 mu L DNA template, 1.4 mM dNTP, 0.16 U/mu L Bst DNA polymerase and DEPC; the primer probe combination comprises a primer probe and a primer probe, wherein the primer probe is designed according to a nuc gene of staphylococcus aureus: GenBank registration number EF529607.1, and the primer probe is designed according to a fimY gene of salmonella: GenBank registration number JQ665438.1; according to the invention, dual detection is realized through a chip and a two-color fluorescence channel carried by an imaging analyzer, and compared with the existing detection method, the method has higher sensitivity and accuracy.
Absstract of: CN119875946A
The invention belongs to the technical field of agricultural biology, and particularly relates to a strain of lactobacillus coryniformis HAU121, a microbial inoculum and application of the microbial inoculum. The microbial inoculum comprises lactobacillus coryniformis HAU121, lactobacillus coryniformis HAU121, lactobacillus coryniformis HAU121, lactobacillus coryniformis HAU121 and lactobacillus coryniformis HAU121. According to the invention, a strain of lactobacillus clavuliformis HAU121 is screened from rumen fluid of dairy cow, the strain has stable acid production performance, and the stable acid production performance ensures that the strain rapidly inhibits the growth of other microorganisms in the fermentation process; bacteriostatic activity detection finds that the strain HAU121 has different degrees of inhibition capability on escherichia coli, staphylococcus aureus, salmonella and pseudomonas aeruginosa. The strain HAU121 provided by the invention is applied to solid anaerobic fermentation of cottonseed meal, the removal rate of free gossypol in the fermented cottonseed meal can reach 75.20%, and the strain HAU121 has no obvious negative influence on the nutritional value of the cottonseed meal, and has important application value in the aspect of feed development and utilization of the cottonseed meal.
Absstract of: CN119875984A
The invention discloses a salmonella YeaZ gene deleted strain as well as a construction method and application thereof, and belongs to the technical field of gene engineering. The YeaZ gene deletion strain is constructed by utilizing a lambda-Red homologous recombination technology, and compared with a WT strain, the constructed salmonella YeaZ gene deletion strain can enter a VBNC state more easily and cannot revive in the VBNC state, and pathogenic bacteria in food can be detected by utilizing the characteristics of special biological phenotype and difficulty in reviving of the salmonella YeaZ gene deletion strain.
Absstract of: CN119876424A
The invention discloses a chicken salmonella enteritidis infection related biomarker and application thereof, and belongs to the technical field of poultry genetic breeding and propagation. The invention finds that the content of RUNX2 transcription factors in cecum T cells infected by salmonella enteritidis is obviously different, the expression quantity of RUNX2 in a susceptible group is far higher than that of RUNX2 in a resistance group, which indicates that the RUNX2 is a susceptible gene infected by salmonella enteritidis, and if a chicken shows typical enteritis symptoms such as diarrhea, inappetence and the like and the expression level of RUNX2 is detected to be obviously increased, the RUNX2 is a susceptible gene infected by salmonella enteritidis. This may be a marker of a chicken susceptible to Salmonella enteritidis; if the chicken does not show corresponding symptoms and the expression level of the RUNX2 is not greatly increased, the chicken is indicated to have resistance to the salmonella enteritidis, the resistance of the chicken to the infected salmonella enteritidis can be identified on the molecular level through a single-cell transcriptomics technology, and a technical support is provided for breeding poultry varieties resistant to salmonella enteritidis infection.
Absstract of: CN119868246A
The invention belongs to the field of oral care products and provides antibacterial mouthwash which is prepared from the following raw materials in percentage by mass: 20-30% of lactobacillus plantarum powder, 25-30% of plant extract, 10-15% of humectant, 2-3% of preservative and 0.5-2% of pH regulator. 5-12% of an antibacterial synergist; 2-3% of a sweetening agent and 17-35% of deionized water; the plant extracts comprise a honeysuckle flower extract, a Philippine violet herb extract, a left-hand fragrant extract, a tea leaf extract and a licorice root extract; lactobacillus plantarum powder is provided by Shanghai Shanghai Shanghai Shanghai Detection Technology Co., Ltd., and the product number is BNCC299253. The toothpaste can play a good role in protecting helicobacter pylori, salmonella, listeria monocytogenes, enterobacter sakakaakii and the like, can relieve swelling and aching of gum, oral mucosa bleeding and other symptoms, and avoids halitosis. And the toothpaste also has a very good prevention effect on diseases such as oral ulcer, gingivitis and periodontitis.
Absstract of: CN119876431A
The invention discloses a primer group for detecting polymyxin drug resistance genes (mcr-1 to mcr-10) of bacteria, a multiplex PCR (Polymerase Chain Reaction) method and application. The primer group comprises 10 pairs of primers which are respectively used for carrying out specific PCR (Polymerase Chain Reaction) amplification on mcr-1 to mcr-10 genes. Based on the primer group, a one-step multiplex PCR method for efficiently detecting the genes from mcr-1 to mcr-10 is established. According to the method disclosed by the invention, efficient, specific and sensitive detection of mcr-1 to mcr-10 genes can be realized through one-step reaction of a reaction system. The method provided by the invention is used for detecting escherichia coli and salmonella isolates and comparing with a genome sequencing result, so that the accuracy of the method provided by the invention is further verified. The invention fills the blank of lack of mcr-1 to mcr-10 gene multiplex PCR primer groups and methods at present, and has good application prospects in the fields of clinical detection and microbial prevention and control.
Absstract of: CN119876330A
The invention discloses a method for achieving the antibacterial purpose through cooperation of natural plant essential oil and potassium hydrogen persulfate composite salt, and relates to the technical field of antibacterial treatment. According to the method for synergistically achieving the antibacterial purpose through the natural plant essential oil and the potassium hydrogen persulfate composite salt, the natural plant essential oil with high antibacterial activity is obtained by testing the antibacterial effect of different natural plant essential oil when the natural plant essential oil is independently used, and the natural plant essential oil and the potassium hydrogen persulfate composite salt are compounded through a chessboard method, so that the antibacterial effect of the natural plant essential oil is achieved. The bacteriostatic effect of the compound solution is quantitatively analyzed through part of bacteriostatic concentration indexes, accurate reference data is provided for judgment of the interaction relation between the natural plant essential oil and the potassium hydrogen persulfate compound salt, support is provided for improvement of bacteriostatic efficiency, reduction of the drug use amount and expansion of a bacteriostatic spectrum, and the method has a wide application prospect. The defects of single natural plant essential oil in use are overcome, the cost and the use dosage are reduced, and the natural plant essential oil has a good applicati
Absstract of: CN119876046A
The invention discloses a salmonella bacteriophage JN06 and an application thereof. The preservation number of the salmonella phage JN06 is GDMCC (China General Microbiological Culture Collection Center) No: 65479-B1, and the salmonella phage JN06 is preserved in Guangdong Province Microbial Culture Collection Center on November 13, 2024. The Salmonella lyase has the advantages that the Salmonella lyase is simple in preparation method and wide in host spectrum, not only can be used for lysing various serotypes of salmonella, particularly can be used for lysing Salmonella Schwarzenge Salmonella vaporariorum, but also can be used for lysing Escherichia coli at the same time. The method has the advantages of short incubation period, high outbreak amount, strong tolerance to temperature and pH value, wider application range, and no virulence gene and drug-resistant gene.
Absstract of: CN119881118A
The invention belongs to the technical field of food-borne pathogenic bacterium detection, and discloses a detection method for targeted analysis and detection of salmonella based on a characteristic peptide, and the method detects salmonella pollution in a dairy product by analyzing the following characteristic peptides: I1: (LLADDLVPSR; i2: (IGTISTTGEMSPLDAR), and I3: ( I3: (IELALFLDSYIPEPER), and a method for preparing the same. And I4: (AVAAVEELK). The method for identifying the type of the strain by taking the characteristic peptide as an index is a relatively safe food detection method, the characteristic peptide of a specific microorganism is used for screening, and the characteristic peptide is detected through a targeted mass spectrometry analysis technology, so that the detection of pathogenic bacteria is converted into the detection of the characteristic peptide. The method has the advantages of rapidness, high throughput, high reliability, no dependence on bacterial colony purity and the like. By obtaining a characteristic peptide combination with good specificity, the technology can realize detection of various specific microorganisms.
Absstract of: CN119876412A
The invention relates to a CNTN5 gene related to the resistance character of host salmonella pullorum and an SNP molecular marker and application thereof, the CNTN5 gene and the SNP molecular marker thereof are used for breeding or auxiliary breeding of chicken varieties with high resistance to salmonella pullorum, the nucleotide sequence of the CNTN5 gene is as shown in SEQ ID NO.1, the SNP molecular marker of the CNTN5 gene is located in the intron region of the CNTN5 gene of the first chromosome of the chicken, and the SNP molecular marker of the CNTN5 gene is located in the intron region of the CNTN5 gene of the first chromosome of the chicken. At the site 185063016bp of the chromosome 1, the polymorphism is T or C; when the basic group at the SNP molecular marker of the CNTN5 gene is T, the chicken has high resistance to salmonella pullorum; when the basic group at the SNP molecular marker of the CNTN5 gene is C, the chicken has low resistance to salmonella pullorum. By utilizing the CNTN5 gene and the SNP molecular marker provided by the invention, a chicken variety with high resistance to salmonella pullorum can be quickly and effectively screened and bred.
Absstract of: CN119876374A
The invention relates to the technical field of molecular biology, in particular to a biomarker for detecting salmonella enteritidis infection and application of the biomarker in preparation of a salmonella enteritidis infection detection kit. The invention provides a biomarker for detecting salmonella enteritidis infection, and the biomarker is long-chain RNA (Ribonucleic Acid) Lnc012227. The invention provides a novel molecular marker which can be used for diagnosing and monitoring the infection condition of salmonella in duck ovaries, the characteristic can be used as a reference for evaluating the resistance potential of offspring, a novel strategy and a tool are provided for prevention and control of salmonella infection in the laying duck industry, and the application prospect is wide. The reproductive performance of the laying ducks and the safety of the duck eggs are favorably improved.
Absstract of: CN119875961A
The invention relates to a VBNC salmonella enteritidis resuscitation culture medium and application, and belongs to the technical field of microorganism culture detection. The VBNC salmonella enteritidis resuscitation culture medium comprises 8 g/L-12 g/L of peptone, 3 g/L-7 g/L of sodium chloride, 7 g/L-11 g/L of disodium hydrogen phosphate, 1 g/L-2 g/L of monopotassium phosphate and 0 U/mL-1000 U/mL of Rpf recombinant protein. Experiments prove that the culture medium can detect VBNC salmonella enteritidis which cannot be detected by a traditional culture medium, and the VBNC salmonella enteritidis resuscitation culture medium is proved to be excellent in performance and high in detection rate.
Absstract of: CN119875903A
The invention provides a preparation method of an antibiotic carrier based on bacterial outer membrane vesicles, which is characterized by comprising the following steps: (1) culturing bacteria in a culture medium containing antibiotics; and (2) removing viable bacteria in the culture product, and extracting the outer membrane vesicles of the bacteria to obtain the antibiotic carrier based on the outer membrane vesicles of the bacteria, wherein the bacterium is a salmonella mutant strain QS0074, and the preservation number of the bacterium is CCTCC (China Center For Type Culture Collection) M 2023192; the antibiotic is alcamicin. The antibiotic carrier based on the bacterial outer membrane vesicles, provided by the invention, has excellent drug loading capacity on the acamicin, and has relatively good drug activity stability; the preparation method is simple and easy to popularize.
Absstract of: US2025127889A1
The present disclosure relates to a composition for inducing migration of activated B cells to a germinal center, the composition including a substance that induces CD11b expression in B cells, a production method therefor, or use thereof. In one aspect, the present disclosure relates to immunostimulation and maintenance or improvement of mucosal flora using the substance that induces the CD11b expression in B cells.
Absstract of: WO2025081515A1
The present invention provides a tumor neoantigen vaccine system specifically marking a heterologous protein, and a use thereof. The vaccine system is composed of a heterologous protein mRNA vaccine and a recombinant oncolytic virus; the heterologous protein mRNA vaccine is used to induce an organism to generate heterologous protein-specific memory T cells, and the recombinant oncolytic virus is used to promote a tumor to express microorganism-derived tumor neoantigens. When pre-immunized memory T cells detect these marked specific neoantigens, the tumor expressing the neoantigens is quickly activated and killed, the release of tumor autoantigens is promoted, dendritic cells phagocytize antigens to further initiate an anti-tumor response, and a systemic anti-tumor immune effect is activated by means of antigenic epitope spreading.
Nº publicación: WO2025081938A1 24/04/2025
Applicant:
ROAD ENVIRONMENT TECH CO LTD [CN]
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Absstract of: WO2025081938A1
Provided is a method for preparing a biofloc culture medium by using organic wastes. The method comprises: adding a first auxiliary material to organic wastes, uniformly mixing same to obtain a mixture, and adjusting the water content of the mixture to 45-55%; inoculating an activated Bacillus subtilis seed culture, Bacillus licheniformis seed culture and Saccharomyces cerevisiae seed culture into the mixture according to a ratio, and performing fermentation with stirring and ventilation, so as to obtain a fermented product; adding a second auxiliary material to the fermented product, and uniformly mixing same to obtain the biofloc culture medium. In the finished biofloc product prepared by the method, the viable count of Bacillus subtilis is greater than or equal to 400 million cfu/g, the viable count of Bacillus licheniformis is greater than or equal to 200 million cfu/g, the viable count of Saccharomyces cerevisiae is greater than or equal to 1200 million cfu/g, the total number of bacterial colonies is greater than or equal to 8000 million cfu/g, and no salmonella is detected. The present application can solve the pollution problem of livestock and poultry manure and further achieves recycling utilization of livestock and poultry manure.
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