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3D bioprinting

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LastUpdate Updated on 27/05/2025 [07:29:00]
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微创在体骨组织3D打印修复装置

Publication No.:  CN120000384A 16/05/2025
Applicant: 
北京清华长庚医院
CN_120000384_PA

Absstract of: CN120000384A

本发明提供一种微创在体骨组织3D打印修复装置,其包括:第一球囊导管,其包括第一导管和第一球囊,第一球囊在扩张状态下能够封堵待修复骨组织的长度方向一端的进液;第二球囊导管,其包括第二导管和第二球囊,第二球囊在扩张状态下能够排空待修复骨组织的内部的液体;第三球囊导管,其包括第三导管和第三球囊,第三球囊在扩张状态下能够封堵待修复骨组织的长度方向另一端的进液;和3D打印导管,其能够在由第一球囊和第三球囊分别封堵待修复骨组织的长度方向一端和长度方向另一端的进液、且由第二球囊排空待修复骨组织的内部的液体之后,并且在将第二球囊导管撤出之后,将用于对待修复骨组织进行修复的打印材料挤出至待修复骨组织的内壁上。

光聚合引发剂

Publication No.:  CN120019084A 16/05/2025
Applicant: 
科巨希化学股份有限公司
CN_120019084_A

Absstract of: TW202432621A

To provide a photopolymerization initiator that has low inhibition of polymerization by oxygen, good photopolymerization initiation properties in air, high sensitivity to long wavelength light, and can suppress the occurrence of odor and bleed-out problems in the resulting cured product. A photopolymerization initiator having one or more benzopheno groups and one or more saturated or unsaturated 5-membered or more cyclic substituent having one or more heteroatoms, and at least one carbon atom of the aryl group of the benzopheno group is connected to the saturated or unsaturated 5-membered or more cyclic substituent having one or more heteroatoms though a carboxylic acid ester group or a carboxylic acid amide group.

一种3D打印的可降解骨缺损填充块

Publication No.:  CN120000845A 16/05/2025
Applicant: 
广州湘龙高新材料科技股份有限公司
CN_120000845_A

Absstract of: CN120000845A

本发明提供一种3D打印的可降解骨缺损填充块及其制备方法,所述骨缺损填充块以3D打印技术一体成型制得,所述骨缺损填充块的材质为锌合金,按重量百分比计,所述锌合金的组分包括镁0.1‑2%、杂质<0.2%、锌>98%、上述各组分重量百分百之和为100%。

用于材料改性的方法和系统

Publication No.:  CN120018869A 16/05/2025
Applicant: 
爱德华兹生命科学公司
CN_120018869_PA

Absstract of: WO2024044071A1

Systems and methods for improving biocompatibility and mechanical properties of cardiac repair and regenerative devices are described. Laser techniques can be applied for material modification of various parts of cardiac repair and regenerative devices including patterning on the frame, leaflets, and/or skirt material. Material modification can aid in healing, tissue acceptance, and/or anchoring of the prosthetic valve.

医用3D打印装置

Publication No.:  CN120000383A 16/05/2025
Applicant: 
北京清华长庚医院
CN_120000383_PA

Absstract of: CN120000383A

本发明提供了一种用于骨组织的在体修复和重建的新型的医用3D打印装置。该医用3D打印装置包括:打印材料供给装置,其供给包含骨粉和骨水泥的打印材料;第一通道管,其构成为前端能够插入至骨组织;第二通道管,其以可移动的方式设置于第一通道管内,并且其前端连接有自膨胀覆膜支架;打印导管,其以可移动的方式设置于第二通道管内,具有与打印材料供给装置连接的输送管和设置于输送管的前端的打印喷头;和穿刺部件,其构成为能够将覆膜支架的覆膜刺破。根据本发明,能够实现手术创伤小,与患者解剖结构匹配度高,且能够排除体内的组织液等的干扰,实现在手术过程中实时、精准的在体打印。

一种生物医用复合材料及其制备方法

Publication No.:  CN120006131A 16/05/2025
Applicant: 
湖南省妇幼保健院深圳升华三维科技有限公司
CN_120006131_PA

Absstract of: CN120006131A

本发明提供一种生物医用复合材料的制备方法,属于生物医用材料技术领域,包括以下步骤:将钽、铌、锆粉末混合均匀后采用3D打印技术制备多孔钽‑铌‑锆骨架;称量金属单质和无机物,将金属单质与无机物置于石墨坩埚中放入加压感应炉内,通入保护性气氛,加热加压感应炉并搅拌,制得孔内填充物;将制备的多孔钽‑铌‑锆骨架全部浸入孔内填充物,继续通入保护性气氛并保温;待加压感应炉冷却后即制得生物医用复合材料。本发明可解决现有合金作为生物医用材料力学性能不适配、生物相容性差的问题。

一种具备消毒功能的医用胶片打印机

Publication No.:  CN120003170A 16/05/2025
Applicant: 
柯尼达控股集团有限公司
CN_120003170_PA

Absstract of: CN120003170A

本发明涉及医用器械技术领域,尤其是指一种具备消毒功能的医用胶片打印机,包括胶片打印机主体,胶片打印机主体的前侧开设有操作槽,操作槽内设置有操作屏,操作槽内设置有紫外线灯,胶片打印机主体的顶部固定设置有手卷架,手卷架内设置有绕卷组件,绕卷组件上绕卷有密封帘,密封帘的底端滑动贯穿手卷架并延伸至操作槽内,密封帘前侧的底部固定安装有配重块;本发明在配重块带动密封帘下降时密闭操作槽的过程中,此时气流会通过通孔将减速伞面吹动并鼓起,使得减速伞面因受到气流阻力而向上拉动密封帘,从而实现了对密封帘减少下降的效果,避免配重块将密封帘拉扯损坏和砸坏胶片打印机主体的效果,有助于延长该打印机的使用寿命。

一种乳牙牙体预备用引导导板的压印制作装置

Publication No.:  CN222870673U 16/05/2025
Applicant: 
徐州医科大学徐州市口腔医院
CN_222870673_U

Absstract of: CN222870673U

本实用新型公开了一种乳牙牙体预备用引导导板的压印制作装置,包括:压印模型、导板、修剪凸起;压印模型在计算机软件中根据患者牙列模型设计,压印模型通过3D打印技术打印成实体;导板通过压膜膜片在压印模型上压印而成;压印模型上分布有修剪凸起,修剪凸起沿压印模型的牙列轴面环绕形成导板的边缘修剪路径,修剪凸起沿压印模型上患牙的咬合面、轴面环绕形成导板的开窗路径,修剪凸起上设有沿其路径开设的凹槽;本实用新型在制作备牙导板时通过不同结构的修剪凸起进行引导,能够避免裁切工具在操作时易脱离修剪凸起的凸面,而造成导板裁切边缘不平整,以及预备引导窗尺寸开设不精准的问题,以通过使用尺寸精准的备牙导板提高备牙调磨精度。

Strahlungshärtende Zusammensetzung für die Herstellung dentaler Bauteile in einem 3D-Druck-Verfahren

Publication No.:  DE102023131266A1 15/05/2025
Applicant: 
KULZER GMBH [DE]
Kulzer GmbH

Absstract of: DE102023131266A1

Die Erfindung betrifft ein strahlungshärtende Zusammensetzung für die Herstellung dentaler Bauteile in einem 3D-Druck-Verfahren, umfassend bezogen auf die Gesamtmasse der strahlungshärtenden Zusammensetzung: i) ein oder mehrere radikalisch polymerisierbare Monomere in einem kombinierten Massenanteil von 30 % oder mehr, ii) einen oder mehrere erste Füllstoffe in einem kombinierten Massenanteil von 5 % oder mehr, wobei der oder die ersten Füllstoffe einen mittleren Partikeldurchmesser D50 von 150 nm oder weniger aufweisen, iii) einen oder mehrere vom ersten Füllstoff verschiedene zweite Füllstoffe in einem kombinierten Massenanteil von 5 % oder mehr, wobei der oder die zweiten Füllstoffe ausgewählt sind aus der Gruppe bestehend aus Feldspaten, und iv) einen oder mehrere Photoinitiatoren mit einem kombinierten Massenanteil im Bereich von 0,001 bis 10 %, wobei der kombinierte Massenanteil an Füllstoffen 30 % oder mehr beträgt.

ALLOPLASTIC AURICLE PROSTHESIS AND METHOD FOR MANUFACTURING THE SAME

Publication No.:  WO2025099555A1 15/05/2025
Applicant: 
POLITECNICO DI MILANO [IT]
UNIV DEGLI STUDI DI MILANO [IT]
FOND IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO [IT]
POLITECNICO DI MILANO,
UNIVERSITA' DEGLI STUDI DI MILANO,
FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO
WO_2025099555_PA

Absstract of: WO2025099555A1

The invention relates to an alloplastic prosthesis (20) for the complete or partial reconstruction of the outer ear (22) of a patient (24). The alloplastic prosthesis comprises a plurality of shaped layers (26) stacked and joined to each other, wherein some layers are made of thermoplastic polyurethane (TPU) and other layers are made of polycaprolactone (PCL); at least the outer surface of the alloplastic prosthesis comprises a plurality of pores (28) having a predefined structure and surface comprised between 0.1 mm2 and 0.2 mm2. The invention further relates to a method (100) for manufacturing the alloplastic prosthesis.

Surgical implant device incorporating a lattice volume and associated method of manufacture

Publication No.:  AU2025202950A1 15/05/2025
Applicant: 
KYOCERA MEDICAL TECHNOLOGIES INC
KYOCERA MEDICAL TECHNOLOGIES, INC
AU_2025202950_A1

Absstract of: AU2025202950A1

The present disclosure provides a surgical implant device, including: a solid surface; and a lattice structure disposed adjacent to the solid surface, wherein the lattice structure includes a first plurality of struts that define a first plurality of voids adjacent to the solid surface and a second plurality of struts that define a second plurality of voids remote from the solid surface. The surgical implant device may also include one or more screw hole regions and/or a needle-populated porous surface disposed adjacent to the solid surface opposite the lattice structure. Fig 1 10,16 12 14b 14c14

RADIATION-CURING COMPOSITION FOR PRODUCING DENTAL COMPONENTS IN A 3D PRINTING PROCESS

Publication No.:  WO2025099123A1 15/05/2025
Applicant: 
KULZER GMBH [DE]
KULZER GMBH
WO_2025099123_A1

Absstract of: WO2025099123A1

The invention relates to a radiation-curing composition for producing dental components in a 3D printing process, comprising, based on the total mass of the radiation-curing composition: i) one or more radically polymerisable monomers in a combined mass fraction of 30% or more; ii) one or more first fillers in a combined mass fraction of 5% or more, wherein the first filler or fillers has or have an average particle diameter D50 of 150 nm or less; iii) one or more second fillers, different from the first filler, in a combined mass fraction of 5% or more, wherein the second filler or fillers is or are selected from the group consisting of feldspars; and iv) one or more photoinitiators having a combined mass fraction in the range of 0.001 to 10%, wherein the combined mass fraction of fillers is 30% or more.

3D PRINTED ELECTRONIC SKIN AND USES THEREOF

Publication No.:  WO2025101955A1 15/05/2025
Applicant: 
THE TEXAS A&M UNIV SYSTEM [US]
ROY SHOUNAK [US]
DEO KAIVALYA [US]
GAHARWAR AKHILESH K [US]
THE TEXAS A&M UNIVERSITY SYSTEM,
ROY, Shounak,
DEO, Kaivalya,
GAHARWAR, Akhilesh, K
WO_2025101955_PA

Absstract of: WO2025101955A1

Provided herein are hydrogels nanoengineered as a 3D-printed wearable electronic skin conformable to human skin and methods for nanoengineering the hydrogels. The hydrogel may be nanoengineered to have a crosslinked pullulan- SH/polydopamine/molybdenum disulfide network (Pul-SH/PDA/MoS2). Also provided are methods for detecting and monitoring physiological changes via the wearable electronic skin and for diagnosing a disease or disorder based on the physiological changes.

BIOMETRIC SENSING AND MONITORING SYSTEMS AND DEVICES EMPLOYING A MICROWAVE SENSOR UNIT AND METHODS FOR USING THE SAME

Publication No.:  WO2025102004A1 15/05/2025
Applicant: 
LIGHT PETER EDWARD [CA]
BAGHELANI MASOUD [CA]
LIGHT, Peter Edward,
BAGHELANI, Masoud
WO_2025102004_PA

Absstract of: WO2025102004A1

Provided herein is a non-invasive biometric sensing and monitoring device that may be employed in a non-invasive method with the potential for comprehensive analysis and data processing. The non-invasive biometric sensing and monitoring device may be employed for determining a characteristic of a state of a wearer using the device based on a value of a biomolecule within a body tissue of the user. The device may include a housing for retaining one or more components of the biometric device. The components may may include a substrate, such as a printed circuit board, and may further include one or more of an signal generator, a microwave structure based sensor unit, a filter unit, a receiver component, an analog to digital converter, a control unit, one or more buffers, a communications module and controller as well as an analytics system.

STEREOLITHOGRAPHIC RESIN COMPOSITION

Publication No.:  WO2025100441A1 15/05/2025
Applicant: 
KURARAY NORITAKE DENTAL INC [JP]
\u30AF\u30E9\u30EC\u30CE\u30EA\u30BF\u30B1\u30C7\u30F3\u30BF\u30EB\u682A\u5F0F\u4F1A\u793E
WO_2025100441_A1

Absstract of: WO2025100441A1

The present invention provides a stereolithographic resin composition which is excellent in modeling accuracy, strength, toughness, and water resistance of a modeled article, and has little eluate from a modeled article. The present invention relates to a stereolithographic resin composition that contains a polyfunctional (meth)acrylic polymerizable compound (A) and a photopolymerization initiator (B) containing four or more heteroatoms per molecule. The stereolithographic resin composition preferably also contains a monofunctional (meth)acrylic polymerizable compound (C). The polyfunctional (meth)acrylic polymerizable compound (A) preferably contains a polyfunctional (meth)acrylic polymerizable compound (A)-I having a molecular weight of less than 500.

A SHRINKING AND SETTING BIOINK

Publication No.:  WO2025099720A1 15/05/2025
Applicant: 
RAMOT AT TEL AVIV UNIV LTD [IL]
RAMOT AT TEL-AVIV UNIVERSITY LTD
WO_2025099720_PA

Absstract of: WO2025099720A1

Provided is a hybrid hydrogel composition and methods for its preparation and use in 3D printing biomaterials for tissue engineering applications. The hybrid hydrogel composition comprises discrete hydrogel particles of a first crosslinked polymeric network, interpenetrated- through and threaded by a second crosslinked polymeric network, dispersed in a medium. The first polymer is a thermo-responsive polymer, while the second is a protein-based thermo¬ denaturing polymer. The process for preparing this composition involves mixing swelled hydrogel nanoparticles of the first polymer with a non-crosslinked hydrogel of the second polymer in the presence of a crosslinking agent for the first polymer. The 3D printing method utilizes this composition below the LCST of the thermo-responsive polymer, followed by temperature increase wherein the second polymer cures and fixes the printed ink. This approach enables the creation of high-resolution structures, including artificial tissues with capillary blood vessels, featuring dimensions less than 50 μm.

SYSTEMS AND METHODS FOR PRINTING HIGH-DENSITY TISSUE FIBERS

Publication No.:  WO2025099487A1 15/05/2025
Applicant: 
ASPECT BIOSYSTEMS LTD [CA]
ASPECT BIOSYSTEMS LTD
WO_2025099487_PA

Absstract of: WO2025099487A1

Aspects of the disclosure include microfluidic print heads for bioprinting core/shell fibers having consistent diameters and shell thicknesses, and methods of making high-density tissue fibers comprising cell populations of therapeutic interest for implantation, as well as the high-density tissue fibers produced thereby.

CRYOPRESERVATION OF BIOPRINTED TISSUE FIBERS

Publication No.:  WO2025099488A1 15/05/2025
Applicant: 
ASPECT BIOSYSTEMS LTD [CA]
ASPECT BIOSYSTEMS LTD
WO_2025099488_PA

Absstract of: WO2025099488A1

Aspects of the disclosure include cryopreserved tissue fibers and multilayer structures comprising said fibers, wherein the fibers encapsulate dissociated cells, and where the fibers and/or structured are cryopreserved prior to aggregation of the encapsulated cell population. Methods of making and using such fibers and structures are also provided.

DEVICE FOR TREATING SNORING AND APNEA

Publication No.:  WO2025097229A1 15/05/2025
Applicant: 
FABER JORGE [BR]
FABER, Jorge
WO_2025097229_PA

Absstract of: WO2025097229A1

The present invention relates to a dental device for treating snoring and apnea (1) which is made using a 3D digital model and 3D printers and is composed of an upper plate (4) and a lower plate (6) that are joined by interlocking mechanisms (8, 9) that limit the opening of the mouth, optimizing the results of the treatment for snoring and apnea. The device is an apparatus for bringing the lower jaw forward that does not contain metal elements incorporated into the design of the apparatus, making manufacture easier and cheaper, as well as making the device more hygienic. Additionally, the forward movement of the lower jaw (7) is not achieved using screws or metal wires, but rather by sequentially and incrementally changing the plates, thus increasing the caliber of the airways, wherein the forward movement results from changes in the positioning of the interlocking mechanisms (8, 9).

Partially Porous Tibial Component

Publication No.:  US2025152374A1 15/05/2025
Applicant: 
HOWMEDICA OSTEONICS CORP [US]
Howmedica Osteonics Corp
US_2025073041_PA

Absstract of: US2025152374A1

A method for removing a stem portion of an orthopedic implant from a bone comprises exposing an implanted orthopedic implant having a body portion, a stem portion interconnected to the body and a porous metal section forming an interconnection between the body and the stem portion. A cutting tool is mounted on a holder connected to an exposed surface of the orthopedic implant. The porous section is aligned with the cutting tool mounted on the holder. The entire porous section is cut by moving the cutting tool therethrough in a direction transverse to the stem portion axis. The implant body portion is then removed and then the stem portion is removed from the bone. The cutting tool may be a saw or chisel which may be mounted on a guide fixed to the body portion.

SYSTEMS AND METHODS TO REPAIR TISSUE DEFECTS

Publication No.:  US2025151975A1 15/05/2025
Applicant: 
SCRIPPS HEALTH [US]
Scripps Health
US_2023233058_PA

Absstract of: US2025151975A1

Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.

CONTINUOUS LIQUID INTERPHASE PRINTING

Publication No.:  US2025152925A1 15/05/2025
Applicant: 
CARBON INC [US]
Carbon, Inc
US_2024082553_PA

Absstract of: US2025152925A1

A method of forming a three-dimensional object is carried out by providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; filling the build region with a polymerizable liquid; irradiating the build region through the optically transparent member to form a solid polymer from the polymerizable liquid and advancing the carrier away from the build surface to form the three-dimensional object from the solid polymer, while also concurrently with the irradiating and/or advancing steps: (i) continuously maintaining a dead zone of polymerizable liquid in contact with the build surface, and (ii) continuously maintaining a gradient of polymerization zone between the dead zone and the solid polymer and in contact with each thereof. The gradient of polymerization zone comprises the polymerizable liquid in partially cured form (e.g., so that the formation of fault or cleavage lines between layers of solid polymer in the three-dimensional object is reduced). Apparatus for carrying out the method is also described.

HYBRID 3D PRINTER HAVING DISPENSER WITH MOVABLE LIGHT SOURCE

Publication No.:  US2025153425A1 15/05/2025
Applicant: 
ALIGN TECH INC [US]
Align Technology, Inc
US_2024391162_PA

Absstract of: US2025153425A1

A method of three-dimensional (3D) printing includes heating a photo-curable material and extruding the photo-curable material from a nozzle of a dispenser to form a first layer of an object according to a digital file, wherein the first layer has a first shape specified by the digital file, and wherein the first shape has a first minimum line width based on a diameter of the nozzle. The method further includes directing a light beam onto the first layer according to the digital file or an additional digital file to cure a portion of the first layer, wherein the cured portion of the first layer has a second shape, wherein the second shape may comprise features that are smaller than the first shape. The light source is attached to the dispenser and is movable to adjust a direction of the light beam relative to the nozzle of the dispenser.

MONOMERIC AND POLYMERIC COMPOSITIONS AND METHODS OF PRODUCING AND USING THE SAME

Publication No.:  US2025154305A1 15/05/2025
Applicant: 
ALIGN TECH INC [US]
Align Technology, Inc
US_2025034305_PA

Absstract of: US2025154305A1

The present disclosure provides photo-polymerizable monomers, photo-curable resins comprising one or more of such monomers, as well as polymeric materials formed from the photo-curable resins. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

ON-THE-FLY MOLDING

Nº publicación: US2025153399A1 15/05/2025

Applicant:

3DSIL LTD [IL]
3DSIL LTD

US_2023066023_PA

Absstract of: US2025153399A1

A method of fabricating an object from a heat curable polymer such as silicone is provided. The method is carried out by using additive manufacturing to fabricate a portion of a mold and filling the portion of the mold with the heat curable polymer. The polymer is then heated and the steps of mold fabrication and filling are repeated until the object is fabricated.

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