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196
results.
Updated on
06/11/2025 [06:52:00]
Results 100 to 125 of 196
Absstract of: US2025319037A1
The object of the present invention is to provide a method for delivering a therapeutic agent to endothelial cells, mesenchymal cells, or cancer cells which can realize excellent delivery efficiency to organs other than the liver, and a composition containing a therapeutic agent and lipid nanoparticles which can realize excellent delivery efficiency to an organ other than the liver. The present invention provides a method for delivering a therapeutic agent to endothelial cells, mesenchymal cells, or cancer cells, which comprises administering a lipid composition to a subject, wherein the lipid composition comprises the therapeutic agent and lipid nanoparticle,and wherein the lipid nanoparticle comprises an ionizable lipid and a compound represented by formula (1) or a salt thereof.wherein G1 represents —C(O)—, —OC(O)—, —O(CO)O— or —C(O)O—,LY represents a single bond, an alkylene group having 1-14 carbon atoms, a substituted alkylene group having 1-14 carbon atoms, a heteroalkylene group having 1-14 carbon atoms, and a substituted heteroalkylene group having 1-14 carbon atoms.X represents a basic functional group.
Absstract of: AU2023409836A1
The present disclosure relates compositions of RNA encapsulated in lipid nanoparticles and methods of producing the same The compositions can be used for delivery of mRNA to a subject. The lipid nanoparticles have improved properties for delivery of biologically active agents, such as RNA.
Absstract of: AU2023409835A1
The present disclosure provides lipid nanoparticles having a sphere like structure, compositions comprising the lipid nanoparticles and methods for delivery of the agents. The lipid nanoparticles have improved properties for delivery of biologically active agents, such as RNA.
Absstract of: CN119095585A
An LNP comprising a phospholipid comprising a sterol moiety is provided. The LNP containing the phospholipid has potential application in the mRNA vaccine technology. Compositions comprising the LNPs and methods of using the LNPs or the compositions as described above are provided.
Absstract of: AU2023407128A1
Provided herein is an ionizable, cationic amino lipid or a pharmaceutically acceptable salt thereof. The ionizable, cationic amino lipid has: a protonatable amino head group; two lipophilic chains, wherein the protonatable amino head group has a central carbon atom to which each of the two lipophilic chains are directly bonded; at least one of the two lipophilic chains has a structure of Formula C: Formula C wherein E is an ester in either orientation. The compounds may be formulated in a lipid nanoparticle for use in the delivery of charged cargo such as nucleic acid.
Absstract of: EP4640215A1
Biocompatible and biodegradable nanoparticles based on amorphous calcium phosphate containing ascorbic acid and anti-tumor agents. The use of these nanoparticles as highly stable nanocarriers of these drugs improves their effectiveness in terms of bioavailability, cytotoxicity, induction of apoptosis, inhibition of cell migration, tumor growth and survival.
Absstract of: WO2024137455A1
The present disclosure relates to nanoparticles and nanoparticulate compositions comprising a TLR7/8 agonist and one or more polynucleotides; methods of preparing such nanoparticles and nanoparticulate compositions; and associated methods of medical treatment and uses of such nanoparticles and nanoparticulate compositions for medical treatment, including the use of such nanoparticles for the manufacture of medicaments for medical treatment. Nanoparticles and nanoparticulate compositions disclosed herein may be effective for stimulating or enhancing a therapeutic or protective immune response in a patient, and may be used for the treatment of a proliferative disorder such as a cancer, including metastatic cancer, or may be used for or in the course of immunisation.
Absstract of: CN120418427A
Methods and compositions for genetically modifying cells are provided.
Absstract of: TW202438043A
A compound having the following structure of Formula (I): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, R4, X, Y1, and Y2 are as defined herein. Compositions comprising the compounds, and their use in methods of treating diseases, are also described.
Absstract of: TW202438044A
A compound having the following structure of Formula (I): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, R4, R5, R6, G1, G2, x, y, n, z, and w are as defined herein. Compositions comprising the compounds, and their use in methods of treating diseases, are also described.
Absstract of: NZ766044A
The present invention relates to the medical field, in particular to the treatment of neurological disorders. More specifically the present invention relates medicaments comprising gold (Au), barium titanate (BaTiO3) and/or zirconium dioxide (ZrO2) nanoparticles coated with a biocompatible coating providing a neutral or a negative surface charge, for preventing or treating Parkinson’s disease or Alzheimer’s disease by intra-cranial or intra-thecal administration and provided without exposure of the nanoparticles to an electric current, electric field or electric stimulus applied by deep brain stimulation (DBS), by transcranial electric stimulation (TES), or by transcranial magnetic stimulation (TMS).
Absstract of: CN120837661A
本发明公开了一种双磷酸盐和腺嘌呤核苷三磷酸协同修饰的磷酸钙纳米颗粒及其制备方法和应用，属于生物医药技术领域，包括以下步骤：将氯化钙溶液、Tris缓冲液溶于水中，得到第一溶液；将含磷酸氢二钠的HEPES 缓冲液加入水中，再加入双磷酸盐、腺嘌呤核苷三磷酸，搅拌均匀，得到第二溶液；将第二溶液滴入第一溶液中，搅拌均匀，得到混合液，将混合液离心，洗涤，干燥，得到双磷酸盐和腺嘌呤核苷三磷酸协同修饰的磷酸钙纳米颗粒；本发明通过双磷酸盐、腺嘌呤核苷三磷酸的协同作用，改善磷酸钙纳米颗粒的尺寸，并调整其Zeta电位，从而提高其在体内的循环时间及递送效率和稳定性，提高了核酸疫苗的递送效率，进而增强疫苗的免疫效果。
Absstract of: CN120456928A
Described herein are compounds comprising lipids attached to a polymer backbone having functional groups. Also described herein are uses of such agents for delivering nucleic acids to cells.
Absstract of: CN120077061A
The technology disclosed and described herein relates to multimode mRNA-based immunotherapy that delivers both antigens and immunomodulators. Related formulations, methods of administration, and kits are disclosed and described.
Absstract of: CN120187434A
The present invention relates to compounds for use in methods for treating patients suffering from conditions associated with bacterial or fungal severe sepsis and bacterial or fungal septic shock and conditions resulting therefrom, pharmaceutical compositions containing said compounds and their use as medicaments for the treatment of bacterial or fungal severe sepsis and bacterial or fungal septic shock and the conditions resulting therefrom. # imgabs0 #
Absstract of: US2025242049A1
It is an object of the present invention to provide a lipid composition capable of delivering a nucleic acid such as RNA to a hematopoietic stem/progenitor cell or mesenchymal stem cells, and a method of delivering a therapeutic agent to a cell using the lipid composition. The present invention provides a lipid composition comprising (A) a therapeutic agent and (B) a lipid nanoparticle conjugated to a targeting molecule, wherein the lipid nanoparticle comprises an ionizable lipid, and the targeting molecule specifically binds to a marker of hematopoietic stem/progenitor cells or mesenchymal stem cells.
Absstract of: MX2025004375A
The present disclosure provides compositions, systems, and methods related to cellular transduction. In particular, the present disclosure provides compositions, systems, and methods pertaining to implantable macroporous scaffolds that facilitate rapid and highly efficient cellular transduction.
Absstract of: CN120842107A
本发明提供一种化合物或其N‑氧化物、溶剂合物、药学上可接受的盐或立体异构体，还提供了包含前述化合物的组合物以及它们用于递送治疗剂或预防剂的用途。本发明丰富了阳离子脂质化合物的种类，为核酸药物、基因疫苗、小分子药物、多肽或蛋白质药物的有效递送提供更多选择。当与其它脂质成分形成脂质纳米颗粒后，能够有效地递送mRNA或药物分子到细胞内发挥生物功能。
Absstract of: CN120837449A
本发明属于生物制药领域，具体涉及一种具有内质网靶向的抗氧化功能纳米酶及其制备方法和应用。本发明所提供的新型抗氧化纳米酶(Arg‑Mnzyme)，能有效抑制NOX1的表达消除活性氧的积累，抑制颞下颌关节炎性疼痛后NOX1的激活和氧化应激的发生，发挥了减轻疼痛超敏反应的作用。相比于天然酶而言，纳米酶具有更强的修饰性，本发明将构建一种内质网精准抗氧化纳米酶将实现氧化应激的精准调控。
Absstract of: CN120836673A
本发明公开了一种防控罗非鱼链球菌病的复合抑菌剂及制备方法和应用，复合抑菌剂包括：五倍子鞣质纳米微囊25％～30％、杜仲绿原酸‑壳聚糖复合物25％～35％、黄芩苷磷脂复合物10％～20％、枯草芽孢杆菌GS‑02代谢产物冻干粉5％～15％及酸化改性凹凸棒土余量。在饲料中添加1.5％该复合抑菌剂可显著降低链球菌病累计发病率至5.3％，增重率提高22.1％，饵料系数降至1.21，且无恩诺沙星药物残留。该复合抑菌剂适用于饲料添加、水体泼洒及缓释凝胶剂多种应用场景；特别适用于循环水养殖系统，以缓释凝胶块形式按每10m3水体200g悬挂时，可维持有效抑菌浓度30天，使链球菌累计感染率降至≤1.2％。
Absstract of: CN120837616A
本发明涉及生物医用纳米材料技术领域，具体是超声响应多功能携氧纳米粒子及其制备方法和应用。本发明针对现有骨关节炎治疗载体存在的功能单一、靶向性不足及氧利用率低等问题，通过多级自组装技术构建具有"四合一"功能的智能递送系统，即超声响应多功能携氧纳米粒子，其具有关节微环境pH响应性、软骨细胞靶向性、超声响应释氧、二氧化碳吸附的“四合一”多重功能，通过体内和体外验证了其能够在细胞外微环境超声响应下维护软骨细胞纤维透明化平衡，改善软骨细胞线粒体功能和能量代谢，延缓软骨退变的效果；其具有良好生物相容性，个性化生物学功能，满意的体内外治疗效果，拓展了功能化、个性化生物纳米材料在骨关节炎领域的应用前景。
Absstract of: CN120837497A
本发明属于生物医药技术领域，具体公开金属离子螯合剂TPEN在肺癌治疗中的应用及其联合肺癌免疫治疗制剂在治疗肿瘤中的应用。本公开一方面提供TPEN在治疗肺癌中的应用，还提供TPEN用于增强肺癌免疫治疗疗效的应用，进一步提供TPEN联合肺癌免疫治疗制剂在制备治疗肺癌产品中的应用。本公开中，验证了“铜/锌金属离子螯合‑泛凋亡激活‑免疫微环境重塑”级联反应介导的“肿瘤细胞直接清除”和“抗肿瘤免疫激活”双重作用，并显著抑制原发肿瘤生长，确立的“金属离子螯合驱动泛凋亡”作为一种变革性治疗策略，解决了传统免疫治疗的局限性，并为NSCLC治疗提供了一种有前途的方法。
Absstract of: WO2024190817A1
The present invention addresses the problem of providing: a compound, or a salt thereof, which constitutes a lipid composition that can realize a high nucleic acid encapsulation rate and excellent nucleic acid delivery when mRNA is used; and a lipid composition, a pharmaceutical composition, and a delivery carrier that can realize a high nucleic acid encapsulation rate and excellent nucleic acid delivery when mRNA is used. The present invention provides a compound represented by formula (1), or a salt thereof. In the formula, R1 represents a hydrocarbon group having 1-24 carbon atoms; R2 represents a hydrocarbon group having 1-6 carbon atoms, R3 represents a hydrocarbon group having 6-24 carbon atoms and having a branched chain; R4 and R5 each represents a hydrocarbon group having 1-6 carbon atoms which are optionally substituted; R6 represents a hydrogen atom or a hydrocarbon group having 1-18 carbon atoms; L represents *-O-C(O)- or *-C(O)O -; a represents an integer of 1-12; and b, c, and d each represents an integer of 1-4.
Absstract of: CN120837609A
本发明公开了一种用于治疗牙周炎的金属多酚蛋白质药物无创透膜递送系统，制备方法如下：S1、以香叶酸和碳酸氢胆碱为原料制备离子液体；S2、首先，将表没食子儿茶素‑3‑没食子酸酯(EGCG)溶于Milli‑Q超纯水，搅拌至完全溶解，逐滴加入FeCl3溶液，避光搅拌30‑60min，得到蓝黑色溶液；然后，将PDGF‑BB冻干粉加入蓝黑色溶液中，冰浴静置10‑20min，然后冰浴下超声处理数分钟，冷冻干燥，得到金属‑多酚网络包裹的PDGF‑BB，即为Fe3+@EGCG‑PDGF‑BB纳米粒子；S3、将Fe3+@EGCG‑PDGF‑BB纳米粒子加入步骤S1的离子液体中，超声处理数分钟，得到目标物Fe3+@EGCG‑PDGF‑BBIL。本发明首次将离子液体作为多酚‑蛋白质类药物(PDGF‑BB)纳米粒子的递送载体，得到了高效、安全的蛋白质类药物透牙龈无创治疗牙周炎的全新药物递送系统。
Nº publicación: CN120837525A 28/10/2025
Applicant:
常州大学
Absstract of: CN120837525A
本发明公开了一种钼基ZIF‑67抗菌纳米粒及其制备方法与应用，属于纳米药物技术领域。本发明在40‑65℃下，将四水合钼酸铵分散液加入六水合硝酸钴分散液中，得到含有钼和钴的有机配体溶液；将其加入聚乙烯吡咯烷酮的2‑甲基咪唑分散液中，在0～5℃下静置，加入三乙胺，搅拌反应得到初始反应溶液，进一步在超声作用下反应得到Mo/ZIF‑67溶液，固液分离，洗涤沉淀，过滤，干燥制得钼基ZIF‑67抗菌纳米粒。本发明制备方法实现了钼基ZIF‑67的高效、可控合成，获得结晶度良好、粒径均匀，抗菌效果明显的钼基ZIF‑67抗菌纳米粒材料。
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