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Resultados 54 resultados
LastUpdate Última actualización 15/01/2026 [06:45:00]
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Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days
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CAR T-CELLS COMPRISING AN ANTI CD33, AN ANTI CLL1 AND AT LEAST ONE FURTHER CAR ANTI CD123 AND/OR FTL3

NºPublicación:  US2025381224A1 18/12/2025
Solicitante: 
AUTOLUS LTD [GB]
Autolus Limited
US_2025381224_PA

Resumen de: US2025381224A1

The present disclosure provides a cell comprising: an anti-CD33 chimeric antigen receptor (CAR); an anti-CLL 1 CAR; and an anti-CD123 and/or anti-CAR FLT3 CAR. The cell can be used in the treatment of a disease such as acute myeloid leukemia (AML).

Compositions and Methods for Retrieving Tumor-related Antibodies and Antigens

NºPublicación:  US2025382349A1 18/12/2025
Solicitante: 
THE TRUSTEES OF THE UNIV OF PENNSYLVANIA [US]
The Trustees of the University of Pennsylvania
US_2025382349_PA

Resumen de: US2025382349A1

The present invention includes compositions and methods for retrieving tumor-related antibodies and antigens. In one aspect, the invention includes a method for Sequential Tumor-related Antibody and antigen Retrieving (STAR) which directly and efficiently identifies potent antibodies that can specifically bind to tumor-related antigens on the tumor cell surface. In another aspect, the invention includes a CAR comprising a nanobody, a transmembrane domain, and an intracellular domain, wherein the nanobody is retrieved by a STAR method. In another aspect, the invention includes a CAR T system that targets CD13 and treats acute myeloid leukemia. In another aspect, the invention includes a CAR T system and ADC that targets CDH17 and treats NETs and other types of tumors expressing this antigen, with tolerable toxicities.

IMMUNOTHERAPEUTIC COMPOSITIONS FOR TREATMENT OF GLIOBLASTOMA MULTIFORME

NºPublicación:  US2025381266A1 18/12/2025
Solicitante: 
VARIATION BIOTECHNOLOGIES INC [CA]
Variation Biotechnologies Inc
US_2025381266_A1

Resumen de: US2025381266A1

The present disclosure provides compositions and methods useful for treating Glioblastoma Multiforme (GBM), e.g., compositions comprising virus-like particles (VLPs) comprising Moloney Murine leukemia virus (MMLV) core proteins and the human cytomegalovirus epitopes, gB and pp65, formulated with GM-CSF, which, at dose of at least 10 μg gB/pp65Gag, reverse dysregulation of anti-HCMV immunity in GBM patients.

AAV-Mediated Gene Transfer for Retinopathy

Nº publicación: US2025381236A1 18/12/2025

Solicitante:

OCULOGENEX INC [US]
OCULOGENEX INC

US_2025381236_A1

Resumen de: US2025381236A1

The present invention relates generally to gene therapy for treating ailments that can affect vision such as retinal degeneration, retinal dystrophy, macular degeneration, macular dystrophy, ischemic retinopathies, and glaucoma. Embodiments include systems and treatments that use AAV-mediated gene therapy or non AAV-mediated DNA, mRNA, or protein therapy to target all retinal cells. An AAV virion can be introduced (e.g., via intravitreal or subretinal injection) into an eye of an individual, or systemically, to express a heterologous gene product such as BMI1 protein (B lymphoma Mo-MLV insertion region 1 homolog).

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