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Print Head and Cartridge for an Additive Manufacturing Device for Forming a Drug Delivery Device

Resumen de: US20260335191A1

Print head assembly for an additive manufacturing device for forming a drug delivery device, the print head assembly comprising:—a print head, comprising a print head housing with a receptacle for receiving at least part of a cartridge therein; and—a cartridge having an internal volume for holding a volume of drug delivery material; wherein the cartridge is provided with a level indicator providing a level signal indicative of a level of drug delivery material inside the internal volume, and wherein the print head is provided with a level signal sensor arranged for receiving the level signal of the level indicator of the cartridge.

INTELLIGENT INFUSION BASED ON ANTICIPATING PROCEDURAL EVENTS

Resumen de: US20260334872A1

0000 An intelligent control device provides an option to select a medical procedure and receives a selection of the medical procedure. The intelligent control device also operates an infusion device to administer a medication at a first rate. Further, the intelligent control device identifies a set of events associated with the selected medical procedure, including a procedural event expected to cause a physiological change for which an administration of the medication is prescribed. Moreover, the intelligent control device determines that the procedural event is about to occur based on the infusion information, the physiological information, or the selected medical procedure. After determining that the procedural event is about to occur, and before the procedural event occurs, the intelligent control device prompts an operator to cause an adjustment of the infusion device to administer the medication at a second rate; or the intelligent control device causes the adjustment of the infusion device.

TECHNOLOGY FOR INEXPENSIVE AND QUANTIFIED ASSESSMENT OF INFANT SUCKLING BEHAVIOR

Resumen de: US20260334811A1

Provided herein is a method for evaluating infant suckling behavior, comprising: collecting suckling data from an infant using a vacuum measurement device, transmitting the collected suckling data to a processor, processing the collected suckling data by the processor using a pre-trained Machine Learning (ML) algorithm to identify one or more abnormalities in the infant's suckling behavior, wherein the ML algorithm has been trained on a set of training data comprising a plurality of dimensions associated with the training data, and wherein the identified one or more abnormalities are corresponding to one or more of the plurality of dimensions.

BIOMATERIAL-INK FOR 3D PRINTING

Resumen de: US20260335503A1

Three-dimensional (3D) bioprinting has tremendous potential to aid in the creation of engineered tissues and organs that are so desperately in need. In this disclosure, a new type of bio-ink for 3D bioprinting made of sheared slurries of biomaterial hydrogel, in particular alginate hydrogel having micro-capillary structure (Capgel), in particular Capgel having increased stackability and thus self-assembly capability through the formation of a polyelectrolyte complex “skin” on the outer surfaces of the Capgel block with poly-L-lysine (PLL) coating prior to printing needle extrusion is provided as injectable biomaterial tissue scaffolding system, so that such stackable structure as weave patterns and cylindrical structures can be successfully printed with the new Capgel bio-ink. Further, the micro-capillary structure inherent in the original Capgel blocks is retained in the printed bio-ink making up the larger 3D structures and allows for cell culture in it.

APPARATUS AND METHODS FOR USE WITH IMAGE-GUIDED SKELETAL PROCEDURES

Resumen de: US20260335013A1

0000 A tool (538) is advanced along an insertion path (542) into a skeletal portion within a body of a subject. 3D image data of the skeletal portion is acquired using a 3D imaging device. The tool is positioned at a location along the insertion path and a 2D x-ray of the at least a portion of the tool and the skeletal portion is acquired using a 2D x-ray imaging device. Using at least one computer processor (22), the single 2D x-ray is registered to the 3D image data. The computer processor reconstructs a 3D location of the tool with respect to the skeletal portion based on the at least a portion of the tool in the single 2D x-ray that is registered to the 3D image data, and generates an output, at least partially in response thereto. Other applications are also described.

CELL MACROENCAPSULATION DEVICES, METHOD OF FABRICATION AND USE THEREOF

Resumen de: US20260337551A1

It is provided a cell macroencapsulation device for implanting cells in a recipient comprising cells encapsulated in a porous membrane, wherein the porous membrane consists of a sugar network coated with a polymeric solution comprising porogen, which can be used as a graft to transplant islets while protecting the graft from the immune system as well as providing enhanced convection and diffusion to ensure long-term cell survival and physiological insulin delivery.

PATIENT-SPECIFIC IMMOBILIZATION STRUCTURE AND SYSTEM AND METHOD FOR FABRICATION THEREOF

Resumen de: US20260335674A1

Systems and methods are provided for modelling and fabricating a patient-specific immobilization support. Image data is obtained for characterizing an exposed surface of a body portion and a support structure employed to support the body portion during imaging. The image data is processed to determine a position and orientation of the support structure based on spatial features of the support structure, and surface data associated with the exposed surface of the body portion is segmented from the image data. The segmented surface data and the position and orientation of the support structure are employed to generate a digital model of a patient-specific immobilization structure that is attachable to the support structure for immobilizing the body portion between the patient-specific immobilization structure and the support structure. Prior to fabricating the patient-specific immobilization structure, an initial digital model may be modified, optionally according to beam parameters associated with a treatment plan.

ROBOTIC ENCODING SYSTEM AND METHOD

Resumen de: US20260336889A1

0000 A lockable container encoding system and method is disclosed. The lockable container encoding system is for use in the manufacture of encodable lockable containers, wherein the encodable lockable container comprises an annular sidewall having a plurality of annular rings, the annular rings having an inner and outer surface, the inner surface featuring a plurality of selectable removable tabs for the encoding of lockable containers. The lockable container encoding system includes a tumbler for receiving unencoded encodable lockable containers, a receptor having a sidewall dimensioned and configured to hold a plurality of encodable lockable containers, a first articulating arm comprising a plurality of ring manipulators, a vision system in communication with the ring manipulators to monitor the physical position of the plurality of annular rings of the encodable lockable container, and a second articulating arm comprising a plunger having a shearing blade; wherein the shearing blade comprises guide rails couplable to the shearing blade, wherein the shearing blade removes a plurality of selected removable tabs from an unencoded lockable container to encode the container.

THERANOSTIC DEVICE FOR CANCER IMMUNOTHERAPY

Resumen de: US20260337578A1

Provided herein compositions and methods including bioprinted tissue fibers comprising precisely patterned cancerous and non-cancerous cells that are capable of recapitulating a desired tumor microenvironment in vitro. The subject tissue models enable the automated high throughput screening of anti-cancer therapies in a biologically-relevant human system, and can be further personalized with patient-specific cells.

GUIDANCE IN SPATIAL SETUPS OF A ROOM IN A MEDICAL FACILITY

Resumen de: US20260341481A1

The present invention relates to guidance in spatial setups of a room in a medical facility. In order to provide improvements for a facilitated work procedure in medical interventions, a device (10) for guidance in spatial setups of a room in a medical facility is provided that comprises a data input (12), a data processor (14) and an output interface (16). The data input is configured to provide procedure data (18) about a current executed medical procedure. The data input is also configured to provide spatial data (20) of at least one of the group of staff and equipment relating to the currently executed medical procedure. The data processor is configured to calculate upcoming physical movement of at least one of the group of the staff and the equipment based on the procedure data and the spatial data procedure data. The data processor is also configured to determine, based on the calculated upcoming physical movement, at least one of the group of equipment movement instructions (22) and staff spatial guidance (24). Further, the output interface is configured to provide at least one of the group of the equipment movement instructions and the staff spatial guidance.

INJECTION DEVICE AND ADD-ON DEVICE

Resumen de: US20260341455A1

0000 Disclosed is an injection device for injecting of a dose of a medicament, the injection device including a housing having a body detachably connectable to a container part configured to accommodate a medicament container, a drive mechanism arranged in the body and operable to expel the dose of the medicament from the medicament container, a first antenna disposed on or in a first portion of the body and configured for wireless signal transmission with an electronic container identifier provided on or in the container part, a second antenna disposed on or in a second portion of the body electrically connected to the first antenna and configured for wireless signal transmission with a transceiver of an electronic module of an add-on device connectable to the injection device, and an electronic device identifier configured for wireless signal transmission with the transceiver.

EVALUATION DEVICE, EVALUATION METHOD, AND EVALUATION PROGRAM

Resumen de: US20260341070A1

An evaluation device includes: a memory that stores three-dimensional data of a shape of a foot of a subject measured by a measurement device; and a processor that computes an index value specifying the shape of the foot from the three-dimensional data read from the memory. The processor computes, from the three-dimensional data, at least one index value among an index value related to a frontal plane of the foot, an index value related to a sagittal plane of the foot, and an index value related to a horizontal plane of the foot. The processor evaluates a flat-foot level of the foot of the subject based on the computed index value.

CUSTOMIZED PATIENT-SPECIFIC 3D PRINTED POSITIONING AUGMENT FOR ORTHOPAEDIC SURGICAL IMPLANT

Resumen de: US20260335093A1

An orthopaedic prosthetic component includes a manufactured acetabular shell component having an outer wall and an additively manufactured augment coupled to the outer wall. The augment includes an outer surface that defines a customized patient-specific negative contour shaped to conform to a positive contour of a patient's bone. A method for manufacturing the prosthetic component is also disclosed.

SYSTEM AND METHOD FOR SWEEP TRAJECTORY SIMULATION AND GUIDANCE

Resumen de: WO2026226928A2

Systems and methods for sweep trajectory simulation and sweep trajectory guidance are disclosed. One system includes a processor and a memory containing instructions that configure the processor to receive 3D imaging data, generate ultrasound simulation data, and create 3D models. The system trains a sweep trajectory simulation model using reinforcement learning, with the model being trained on the 3D imaging data, probe position data, and 3D models. The sweep trajectory simulation model is configured to output a time-step vector related to the movement of a catheter, enabling simulation of catheter movement trajectories.

SYSTEM AND METHOD FOR TRANSSEPTAL PUNCTURE SITE SELECTION

Resumen de: WO2026226690A1

A system for transseptal puncture site selection, comprising a processor and a memory communicatively connected to the processor, the processor configured to receive a 3D organ model pertaining to an organ of a subject, receive a treatment plan pertaining to the subject, generate treatment guidance as a function of the treatment plan, wherein generating the treatment guidance comprises determining an optimized access route of the treatment guidance to the area of interest, wherein the optimized access route is optimized for the procedure type, and locating a puncture site of the treatment guidance as a function of the treatment plan, wherein locating the puncture site comprises determining the puncture site using a puncture machine-learning model, wherein the puncture machine-learning model is configured to receive the treatment plan as input and output a puncture site, and generate an overlay for the 3D organ model.

Cartilage Restoration System

Resumen de: US20260335510A1

The Cartilage Restoration System is an injectable hydrogel platform designed to permanently restore, reinforce, and replace fibrocartilaginous and cartilaginous tissues, including intervertebral discs, knee menisci, labra, and articular cartilage, for human and veterinary orthopedic applications, with potential non-orthopedic uses. The system comprises a biocompatible hydrogel precursor with synthetic or natural polymers, natural additives, crosslinking agents activated by thermal, chemical, photochemical, enzymatic, or ionic triggers, and reinforcing agents. Delivered minimally invasively via dual-chamber syringe, catheter, robotic-assisted system, or 3D-printed applicator, the hydrogel polymerizes in situ to form a non-degradable implant with a compressive strength of at least 3-5 MPa, three times that of native tissue. The implant resists degradation, ensures fatigue resistance, and integrates with native tissue through adhesive and bioactive components, sealing defects and supporting lifelong functionality. Modular configurations address disc regeneration, spinal fusion, cartilage repair, and osteochondral defects, with species-specific formulations for veterinary use.

APPARATUS AND METHOD FOR SUBJECT MONITORING AND DIAGNOSING WITH NON-INVASIVE MEASURES

Resumen de: US20260334885A1

An apparatus and method for subject monitoring and diagnosing with non-invasive measures are disclosed. The apparatus includes a memory contains instructions configuring at least a processor to receive non-invasive measurement data associated with a subject, wherein the non-invasive measurement data comprises electrocardiogram (ECG) data received from an ECG machine and echocardiogram (echo) data received from an echocardiogram device, and extract at least an ECG feature of the ECG data and at least an echo feature of the echo data, generate a synthetic computed tomography (CT) image of the subject as a function of the fused non-invasive measurement datum, wherein the synthetic CT image is generated without using CT imaging data or magnetic resonance imaging (MRI) imaging data of the subject as an input, and transmit the synthetic CT image to a remote device.

SYSTEMS AND METHODS FOR IMPLEMENTING AN INDIVIDUALIZED DRUG DELIVERY PROFILE FOR A RECIPIENT OF A COCHLEAR IMPLANT SYSTEM

Resumen de: US20260341452A1

An exemplary system comprises a memory that stores instructions and a processor communicatively coupled to the memory and configured to execute the instructions to perform a process. The process may comprise generating, based on a recipient-specific anatomical structure of a cochlea of a recipient of a cochlear implant system and historical procedure data associated with one or more previously performed lead insertion procedures, an individualized drug delivery profile for the recipient; and controlling, in accordance with the individualized drug delivery profile for the recipient, a release of a drug from a stimulating portion of a stimulating lead within the recipient based on a command transmitted to a cochlear implant that includes the stimulating lead.

METHODS OF TREATING TRAUMATIC ENCYPHALOPATHY SYNDROME

Resumen de: US20260335333A1

0000 Disclosed is a method of treating traumatic encephalopathy syndrome (TES) in a patient in need thereof by administering a therapeutically effective amount of a rho-kinase inhibitor. In one embodiment, the rho-kinase inhibitor is fasudil.

SYSTEM AND METHOD FOR ANALYTE MONITORING

Resumen de: AU2025257886A1

Apparatuses, systems, and methods for autonomously-initiated analyte measurements and/or calculation of analyte concentrations based on the analyte measurements. An apparatus (e.g., an analyte sensor or a sensing device of the analyte sensor) may be configured to take and sets of sensor measurements at a first frequency having a period equal to a threshold number of cycles of the clock. The stored sets of sensor measurements may include first sets of sensor measurements at the first frequency and second sets of sensor measurements at a second frequency, and the first frequency is greater than the second frequency. Another apparatus (e.g., a transceiver, display device, and/or data management system) may be configured to receive sets of sensor measurements conveyed by the analyte sensor, calculate time stamps for the sets of sensor measurements, and calculate analyte concentrations based on the sets of sensor measurements and the calculated time stamps.

METHODS OF ASSESSMENT OF PRE-CLINICAL ALZHEIMER'S DISEASE

Resumen de: AU2025258407A1

Described herein are methods of assessing the risk of dementia in a subject using an odor-based test, or "smell test". These methods can be self-administered by the subject under the instruction of a computing device via a user interface. Methods of administering a smell test as described herein can optionally be combined with measuring and quantifying the level of at least one biomarker for dementia (e.g., CXCL10, CCL2, IL-6) in a biological sample collected from the subject. Also provided are methods to treat dementia (e.g., dementia associated with Alzheimer's disease, dementia associated with a subset of Alzheimer's disease patients with TDP-43 pathology).

SYSTEM FOR CRANIOMAXILLOFACIAL AND ORTHOPAEDIC RECONSTRUCTION

Resumen de: WO2026224693A1

The present disclosure relates to a composition, a method for preparing the composition, and a system for implementing the composition for craniomaxillofacial and orthopaedic reconstruction. The composition comprises silk fibroin microfibres; a polymer matrix including polycaprolactone (PCL), and poly(lactide-co-glycolide) (PLGA) or poly(L- lactide-co-D, L-lactide) (PLDLA); a calcium phosphate ceramic phase comprising hydroxyapatite (HA), tricalcium phosphate (TCP), biphasic calcium phosphate (BCP), borate glass, bioactive glass; and a bioactive agent. The method for preparing the composition comprises the steps of raw silk processing, preparation of the composite filament, 3D printing and injection moulding of composite filament to obtain bone scaffolds, screws and plates. The system comprises a material processing assembly, a filament extrusion unit, a 3D printing apparatus, a moulding apparatus and a control unit. The said composition is intended for fabrication into craniomaxillofacial reconstruction plates, resorbable screws, interference screws, meshes, grafts, segmental defect scaffolds, and orthopaedic load-sharing implants.

APPARATUS AND METHOD FOR CONTROLLING A ROBOTIC FRAMEWORK TO PERFORM IMAGING MODALITIES

Resumen de: US20260334912A1

An apparatus and method for controlling a robotic framework to perform imaging modalities. The apparatus includes at least a processor and a memory communicatively connected to the at least a processor. The memory instructs the processor to receive a target region, receive, from a localization system, the at least a position signal of the catheter, generate, using at least a reinforcement-learning model, a movement vector as a function of the at least a position signal, control, using the at least a processor, the robotic framework, as a function of the movement vector, and generate, as a function of the plurality of ultrasonic signals, a three-dimensional (3D) model of the target region.

SYSTEM, LOCATION TAG ASSEMBLY AND PATIENT SUPPORT APPARATUS FOR LOCATING MOBILE TAGS IN REAL-TIME IN A MEDICAL FACILITY

Resumen de: US20260341496A1

0000 There is provided a system, a patient support apparatus, and a location tag assembly for locating mobile tags in real-time in a medical facility using a plurality of wireless signal modalities where the tags could be worn by patients or attached to equipment. The location tag assembly can be secured to a patient support apparatus which could be located precisely with respect to a wireless locating node. The wireless locating nodes may be used to locate a first type of mobile tag. The location tag assembly may be used to locate a second type of mobile tag. The location information may be transmitted to a server to precisely locate patient support apparatuses, medical equipment, patients and staff in real-time.

DYNAMIC ALLOCATION FOR MULTI-PUMP BOLUS VOLUMES

Nº publicación: US20260335546A1 29/10/2026

Solicitante:

CAREFUSION 303 INC [US]
CareFusion 303, Inc.