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172
resultados
Última actualización
04/09/2025 [07:09:00]
Resumen de: EP4609823A1
Die vorliegende Erfindung betrifft ein Verfahren zum Aufbauen einer dentalen Restauration, mit den Schritten eines Bereitstellens (S101) eines dreidimensionalen Datensatzes, der die räumliche Form der dentalen Restauration und eine räumliche Verteilung zumindest eines Herstellungsmaterials innerhalb der dentalen Restauration angibt; eines Simulierens (S102) einer räumlichen Spannungsverteilung innerhalb der dentalen Restauration bei einer vorgegebenen Belastung auf Basis des dreidimensionalen Datensatzes; und eines Veränderns (S103) des dreidimensionalen Datensatzes auf Basis der simulierten Spannungsverteilung.
Resumen de: WO2024092237A1
Described are continuous manufacturing methods using 3D printing or any similar additive manufacturing technology to produce pharmaceutical dosage forms or pharmaceutical delivery devices. Manufacturing methods using hot-melt extrusion to fabricate filaments for fused deposition modeling (FDM) based 3D printing are disclosed. Methods using FDM based 3D printing to fabricate printed products suitable for pharmaceutical delivery purposes are disclosed. The printed products may have various shapes and configurations.
Resumen de: GB2638786A
3D printing of solid-dosage-forms. A printhead comprising one of an integrated powder dispenser or an integrated peristaltic pump 11, where the printhead may be interchangeable and may comprise a multi-tip array. A 3D printer comprising one or more of the printheads. The peristaltic pump may comprise a thermostatic peristaltic pump and tubing 13 for pumping at up to 160 °C, a temperature controlled chamber 12 for storing semi-solid material, and may comprise dispensing tips 15 for simultaneous printing of multiple items. 3D printing apparatus comprising the 3D printer and a build platform with integrated capsule holders and/or moulds. 3D printing apparatus comprising a conveyer belt and balance. Methods of manufacturing solid-dosage-forms comprising use of the 3D printer to print semi-solid material at up to 160 °C, fill capsules or moulds, or print multiple items simultaneously.
Resumen de: EP4609822A1
Die vorliegende Erfindung betrifft ein Verfahren zum Aufbauen einer dentalen Restauration, mit den Schritten eines Bereitstellens (S101) eines dreidimensionalen Datensatzes, der die räumliche Form der dentalen Restauration und eine räumliche Verteilung zumindest eines Herstellungsmaterials innerhalb der dentalen Restauration angibt; eines Simulierens (S102) einer räumlichen Spannungsverteilung innerhalb der dentalen Restauration bei einer vorgegebenen Belastung auf Basis des dreidimensionalen Datensatzes; und eines Veränderns (S103) des dreidimensionalen Datensatzes auf Basis der simulierten Spannungsverteilung.
Resumen de: US2024191006A1
The present disclosure provides curable compositions comprising one or more of photo-polymerizable monomers as reactive diluents, as well as polymeric materials formed from the curable compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.
Resumen de: CN120571076A
本发明公开了一种基于液相烧结和离子取代同时增强力学性能和生物学性能的3D打印白磷钙石复合支架的制备方法。该方法采用桌面级DLP打印技术作为成型工艺，以白磷钙石作为基体材料，通过Li3PO4掺杂引入液相烧结机制与离子取代反应的协同作用，可同步调控支架的微观结构和物相组成，最终实现力学性能、降解特性及生物活性的综合提升。本发明为骨缺损修复过程中磷酸钙类陶瓷力学性能不足的问题提供了一种有前景的解决方案。
Resumen de: CN120571067A
本发明属于生物医学领域，具体涉及一种用于治疗肝衰竭的原位生物3D打印人工肝脏贴片的构建方法。本发明人工肝脏贴片主要成分是复合水凝胶，包括透明质酸(HA)、明胶(Gelatin)、海藻酸钠(sodium alginate)、甲基丙烯酰化明胶(GelMA)。复合水凝胶具有良好的3D打印性能，通过生物3D打印可实现人工肝脏贴片的规模化构建，为可移植的生物人工肝组织提供了一个潜在的解决方案。本发明所述人工肝脏贴片采用挤出式打印模式，成型速度快，并且内部的肝脏细胞仍能保持较高活性，可保证肝脏基础功能(糖原储存、药物代谢和分泌蛋白的合成等)的重建，在治疗肝功能衰竭疾病中具有重要潜力。
Resumen de: CN120572739A
本发明涉及微系统技术领域，并涉及一种可用于打印装置的声学流体装置,其具有小的尺寸并且可以集成到用于沉积气溶胶的设备中并且通过简单的结构实现具有可调节气溶胶特性的定向气溶胶流。该任务通过一种声学流体装置解决，该声学流体装置至少包括至少一个气溶胶出口部件和至少一个保持部件以及至少各一个用于气体、液体和热量的供用管路和/或排放管路、至少一个电管路和/或电信号管路和至少一个高频电信号管路以及至少一个用于热量传输的部件和至少一个温度传感器和至少一个微声学部件以及至少一个用于传输高频信号的部件和至少一个用于液体传输的部件和至少一个传输气体部件以及至少一个用于定位和/或机械紧固的部件。
Resumen de: CN120570719A
本发明公开了一种个性化治疗冠心病的血管支架及其制备方法，所述制备方法包括如下步骤：S1、根据患者的基本信息、临床表现症状和CT扫描数据，对患者的冠状动脉情况进行分析评估，判断应采用的治疗方式；S2、结合患者的冠状动脉情况，针对患者情况设计出尺寸合适的血管支架，建立不同降解状态下的血管支架模型，对血管支架进行径向支撑性能有限元模拟测试和血流动力学模拟测试，确定适合病人个性化治疗的血管支架数据；S3、根据确定的血管支架数据，选择血管支架材料，根据血管支架尺寸和所选血管支架材料来制备血管支架。本发明能有效地实现冠心病患者的个性化治疗，提高血管支架介入治疗的效果，减少患者的经济成本。
Resumen de: CN120571071A
本发明公开了一种基于载细胞近场直写打印的三层神经导管及其制备方法和应用，特点是三层神经导管的内层为载细胞ALG/GelMA/PEO水凝胶支架，中层为PVA/GelMA静电纺丝膜，外层为熔融近场直写PCL支架，其制备方法包括将纺丝液通过静电纺丝制备为有序纤维膜PVA/GelMA，将有序纤维膜PVA/GelMA加入丙酮/戊二醛溶液得到PVA/GelMA静电纺丝膜的步骤，通过熔融近场直写在静电纺丝膜的任一单面打印直写PCL支架的步骤，将含细胞生物墨水通过载细胞近场直写打印制备为有序载细胞水凝胶支架的步骤，最后制备成三层神经导管，优点是能够加速轴突生长、促进髓鞘再生和改善神经功能恢复。
Resumen de: CN120572021A
本发明公开了一种梯度异质结构锌合金植入物及其激光增材制备方法，首先构建梯度异质结构的三维模型，并经分层切片处理后导入选区激光熔化系统。以切片层为调控单元，在优化的激光能量密度范围内进行动态参数切换：高激光能量密度通过提升熔池热力学条件促进粗大晶粒生长，而低激光能量密度则通过急速冷却实现细小晶粒调控，最终形成具有周期性粗细晶层交替的梯度异质结构。结果显示梯度异质结构锌合金植入物展现出强度与延性的协同提升，其强化机制主要源于非均匀变形引起的应力、层间位错以及粗细晶粒交替层抑制应变局部化的综合作用。此外，该植入物还展现出优异的梯度抗菌作用。这为高性能锌合金植入物的设计和开发提供了可行的策略。
Resumen de: CN120572672A
本发明涉及伤口敷料及其制备方法，包括以下步骤：S1、获取伤口三维尺寸，得到伤口模型；S2、根据伤口模型设计阳模，所述阳模包括基板和设置在基板一侧的多个微针模型，所述微针模型位于伤口模型内，且所有微针模型的尖端均处于伤口三维模型的伤口面上；S3、制备步骤S2设计的阳模；S4、利用阳模倒模制备PDMS微孔模具；S5、将负载药物的水凝胶前驱体溶液注入PDMS微孔模具，得到伤口敷料。本发明的伤口敷料，各个微针的长度与伤口的深度相匹配，使得各个微针的尖端能够有效接触到伤口面，从而有效传递药物，保证伤口的恢复效果。
Resumen de: CN120570728A
本发明涉及医疗美容器械技术领域，且公开了一种基于金字塔结构的鼻整形支撑系统，包括金字塔基元模块、三维桁架系统、梯度孔隙基座、性能参数单元、3D打印参数设置模块、智能适配组件和智能监测模块，金字塔基元模块包括微金字塔结构单元，通过集成了金字塔基元模块、三维桁架系统、梯度孔隙基座、性能参数单元、3D打印参数设置模块、智能适配组件和智能监测模块，形成了一个高度集成化、智能化的鼻整形支撑解决方案，不仅提高了鼻整形手术的精准度和个性化程度，还大大增强了手术的安全性和效果，提高了结构稳定性，避免了在受剪切力时易偏转和单点支撑导致鼻尖皮肤具有穿透风险的情况发生，提高了血管化速率。
Resumen de: CN120570701A
本发明公开了一种唇颊侧及腭侧双固位骨膜下种植体支架及制作方法，种植体支架包括双固位支架主体，双固位支架主体上一侧设有固定于唇颊侧的螺钉孔，双固位支架主体上另一侧设有固定于腭侧的螺钉孔，双固位支架主体的中部设有多个种植基台；双固位支架主体通过扫描数据重建患者完整颌骨结构，提取唇颊侧与腭侧骨面轮廓，得到基础支架模型，然后通过三维有限元分析，对种植基台的布局结合应力分布结果以及唇侧与腭侧的螺钉孔位进行优化，然后采用拓扑优化方法，并通过3D打印制造得到种植体支架。本发明在保证刚度和耐用性的同时，整体结构更加轻便，使用的螺钉数量更少，从而减轻患者佩戴时的压力，显著提高支架的使用寿命，减少压力性损伤的风险。
Resumen de: US2024391170A1
The invention relates to an arrangement for manufacturing a plurality of orthodontic appliances in parallel, including an additive printing machine comprising a build platform and configured for additively manufacturing a plurality of teeth models in parallel, a plurality of plates each configured for teeth model printing by the additive printing machine, whereby each plate comprises a unique machine-readable identifier and each plate is detachable and precisely fixed to the build platform, and a thermoforming machine configured for thermoforming a thermoformable material over the plurality of teeth models for receiving the plurality of orthodontic appliances.
Resumen de: PL447880A1
Przedmiotem zgłoszenia jest sposób wytwarzania endoprotezy stawu biodrowego oraz sposób wytworzenia endoprotezy stawu biodrowego z wypełnieniem strukturalnym, o obniżonej masie i dedykowanej wytrzymałości oraz kształcie do potrzeb. Sposób wytwarzania przedstawionej na rysunku endoprotezy stawu biodrowego charakteryzuje się tym, że obejmuje następujące etapy: przeprowadza się CT i/lub przeprowadza się MRI stawu biodrowego, opracowuje się model numeryczny kości na podstawie badań CT lub badań MRI, przeprowadza się analizę numeryczną i wyznacza się stan naprężeń stawu biodrowego podczas obciążenia wynikającej z motoryki, opracowuje się model geometryczny endoprotezy stawu biodrowego; opracowuje się graniczne parametry wytrzymałościowe endoprotezy stawu biodrowego i dobiera się zagęszczenie wypełnienia strukturalnego endoprotezy stawu biodrowego; analizuje się stan naprężeń stawu biodrowego po endoprotezoplastyce podczas obciążeń wynikającej z motoryki; eksportuje się dane numeryczne z kształtem oraz geometrę wewnętrzną endoprotezy stawu biodrowego, wykonuje się model z wykorzystaniem technik addytywnych, zgęszcza się materiał z wykorzystaniem metod obróbki cieplno-ciśnieniowej w atmosferze gazu obojętnego, zasklepia się otwory technologiczne; obrabia się wykańczająco; sterylizuje się i pakuje się.
Resumen de: US2024294607A1
The present invention relates to isolated, recombinant polypeptides comprising the gamma chain of fibrinogen and a His-Tag. The present invention further relates to nucleic acids encoding said polypeptides, vectors comprising said nucleic acids, host cells, preferably bacterial host cells, comprising said nucleic acids or vectors, biohybrid materials comprising conjugates comprising said polypeptides, uses of the above, and methods for producing said polypeptides.
Resumen de: CN120555818A
本发明涉及一种兼柱状晶向等轴晶转变和强塑性的钛氧铜合金及制备方法，该钛氧铜合金为Ti‑xCu‑yO，其中Cu占钛氧铜合金的重量百分含量比值为2.6≤x≤3.2，O占钛氧铜合金的重量百分含量比值为0.3
Resumen de: CN120550196A
本发明提供了微凝胶生物墨水、包含神经‑血管网络的微凝胶支架及其制法和应用，属于生物医药技术领域。本发明制备得到的微凝胶生物墨水打印时具备显著自愈合能力，确保高精度挤出成型，剪切稀释能力优异，黏度随剪切速率增加显著降低；在生理温度下保持固态结构，具备温敏稳定性；自愈合效果显著，提升打印体机械稳定性，具有良好的打印挤出和成形能力。本发明实现了载神经元与血管内皮细胞微球的复合打印，成功构建了包含神经‑血管网络的微凝胶支架，能够用于模拟体内微环境互作机制，为复杂组织缺损修复提供一体化解决方案。
Resumen de: CN120551422A
本发明涉及医用植入物技术领域，具体是一种基于4D打印的多孔Niti合金仿生骨梯度结构构建方法，包括患者骨数据采集、仿生梯度模型设计、NiTi粉末制备、4D打印、热处理激活记忆效应、表面功能化处理、力学/生物性能测试，其特征在于：包括以下制备步骤：本发明，通过CT/MRI精准获取骨结构数据，结合Mimics预处理与UG/NX建模，针对皮质骨（低孔隙率30%‑40%）和松质骨（高孔隙率50%‑70%）差异化设计孔径与孔隙率，经ANSYS模拟典型载荷工况，使弹性模量（3‑15GPa）、抗压强度（80‑200MPa）接近天然骨，该设计显著降低植入体与宿主骨的弹性模量差，避免应力屏蔽导致的骨吸收问题，同时通过功率渐变技术实现孔隙率连续过渡，提升复杂载荷下的结构稳定性。
Resumen de: CN120549876A
本发明公开了一种基于3D打印的苯巴比妥口崩微片，主要由以下质量百分比的组分采用3D打印技术制备而成：苯巴比妥15％～70％，填充剂10％～60％，崩解剂0％～50％，矫味剂0.1％～2％，粘合剂0％～15％。本发明还公开了该苯巴比妥口崩微片的制备方法。所述的苯巴比妥口崩微片药物释放速度快，可提高患者服用药物的依从性，尤其方便婴幼儿等吞咽困难者服用。
Resumen de: CN120550195A
本申请提供了一种组织工程基质，其包括功能单元、微凝胶、光交联分子和生物活性分子，所述组织工程基质经紫外光光照后能够形成具有高细胞密度的可血管吻合植入的组织或器官。本申请中的组织工程基质由高密度功能单元、微凝胶、光交联分子和生物活性分子复合形成，可以同时满足生物打印要求的力学性能和生物活性，根据功能单元的类型可作为嵌入式打印墨水或挤出式打印墨水，构建形成的组织器官可用于药物开发与筛选、制备病理研究模型或者植入功能补偿病损的组织器官。
Resumen de: US2025268690A1
A method of building a dental restoration, including the steps of providing (S101) a three-dimensional data set indicating the spatial shape of the dental restoration and a spatial distribution of at least one production material within the dental restoration; simulating (S102) a spatial stress distribution within the dental restoration at a predetermined load based on the three-dimensional data set; and changing (S103) the three-dimensional data set based on the simulated stress distribution.
Resumen de: US2025270291A1
The present invention is concerned with a manufactured article prepared from a biomaterial comprising isolated and purified type I collagen fibrils derived from abalone and a method of preparing such an article. The manufactured article can be prepared by 3D bioprinting, and therefore the present invention also envisages a novel bioink for a 3D bioprinter comprising an isolated and purified type I collagen fibril and cartridges containing such a bioink. The invention additionally relates to a method of isolating type I collagen fibrils from abalone. The manufactured article is useful in a number of biomedical applications including as an implantable device where it can function as a 3D bioprinted hard or soft tissue scaffold for tissue engineering.
Resumen de: DE102024105696A1
Die Erfindung betrifft einen Referenzkörper (1) zum Bestimmen einer Abschwächung von Röntgenstrahlung durch ein mittels Röntgenstrahlung untersuchtes Objekt, wobei der Referenzkörper (1) eine zusammenhängende Matrix (2) aus einem Kunstharz mit zugesetztem Röntgenkontrastmittel aufweist. Um einen Referenzkörper (1) anzugeben, welcher in einer Röntgenaufnahme sowohl eine hohe Röntgenkontrastauflösung, als auch eine hohe Ortsauflösung erlaubt, wird vorgeschlagen, dass die Matrix (2) 3D-gedruckt wird, wobei mindestens ein erster Bereich (3, 4, 5, 6,7) und ein zweiter Bereich (3, 4, 5, 6 7) der Matrix (2) definiert werden, indem das Röntgenkontrastmittel dem Kunstharz in dem ersten Bereich (3, 4, 5, 6, 7) in einer ersten definierten Konzentration und in dem zweiten Bereich (3, 4, 5, 6, 7) in einer von der ersten definierten Konzentration abweichenden zweiten definierten Konzentration zugesetzt wird, so dass der erste Bereich (3, 4, 5, 6, 7) einen ersten definierten Röntgenkontrast mit einer ersten CT-Zahl aufweist, welche sich von einer zweiten CT-Zahl eines zweiten definierten Röntgenkontrasts des zweiten Bereiches (3, 4, 5, 6, 7) um mindestens 1 HU unterscheidet.
Resumen de: US2025270389A1
The present invention relates to a stretchable self-healing hydrogel. The hydrogel has excellent mechanical properties and stability, and stretchable and self-healing properties, and can be useful as a hydrogel for delivery of a drug or a cell, and a composition for 3D bioprinters.
Resumen de: US2025270502A1
Methods for fabricating three-dimensional (3D) constructs from a mixture of cells, culture medium, and a scaffold material with a controlled calcium chloride concentration is disclosed. The process involves positioning a nozzle within a gel composed of alginate solution. The nozzle is then moved within the gel, releasing the cell-media-scaffold mixture in a controlled pattern. As the mixture is deposited, it becomes surrounded by the gel, which provides structural support until it solidifies through the cross-linking reaction between the calcium chloride in the cell-media-scaffold mixture and the alginate solution. This results in the formation of a solid 3D structure that incorporates the cells and their supporting scaffold. The presented method offers a versatile platform for generating intricate cell-based 3D constructs with precise control over their composition and structure. This method can be used to produce cultivated meat with complex 3D structures as well as organelles and fully functional organs.
Resumen de: US2025268690A1
A method of building a dental restoration, including the steps of providing (S101) a three-dimensional data set indicating the spatial shape of the dental restoration and a spatial distribution of at least one production material within the dental restoration; simulating (S102) a spatial stress distribution within the dental restoration at a predetermined load based on the three-dimensional data set; and changing (S103) the three-dimensional data set based on the simulated stress distribution.
Resumen de: US2025269083A1
A hollow embolic microsphere, a preparation method, and a pharmaceutical composition and use thereof, wherein: the hollow embolic microsphere is a microsphere prepared using a polymer material and having a unique shape and structure, and is suitable for transcatheter arterial embolization. The hollow embolic microsphere of the present disclosure can enter channels having different sizes, and has embolization effects on various target positions. The hollow microsphere is internally porous and has drug loading abilities, and drug release when loading drug can be easily controlled and the treatment effect is good. No emulsifier or surfactant is needed in the preparation of the hollow microsphere, reaction conditions are mild, and the process is simple. The obtained microsphere has a uniform shape and a controllable size, and is capable of controlling the embolization time. Various drugs including protein heat-sensitive drugs can be loaded, and the drug encapsulation efficiency can reach more than 70%.
Resumen de: US2025268718A1
Apparatus and methods for joint and bony segment replacement may utilize additive manufacturing (e.g., 3D printing) of various anatomic constructs with PEEK/zeolite/ion (PZI) material. Heavy metal ion loading options may be utilized which may provide differing properties to different surfaces of the resultant apparatus. Moreover, using the PZI material, the apparatus being implanted in joint and bony segment replacement may favorably manipulate the biologic microenvironment in which it may be implanted. Further, through use of PZI material, current large joint replacement options also may be disrupted including, but not limited to, modifications of the joint replacement itself, and the augments and supporting joint reconstruction devices used in bone loss situations. Methods for joint and bony segment replacement may provide mixing two or more types of PZI material together through an additive manufacturing process; and introducing the mixture as part of an implantable apparatus.
Resumen de: US2025269094A1
Disclosed herein are apparatuses comprising one or more channels defining a luminal space, wherein the luminal space is defined by an inner wall of fibrous basement membrane material, as well as methods of their manufacture and use.
Resumen de: US2025269656A1
A coupling member includes a valve housing and a hollow movable valve. Relative to the valve housing, the hollow movable valve is positionally displaced in an axis direction between a position in a connected state where the coupling member is connected to another coupling member and a position in a disconnected state where the coupling member is disconnected from the other coupling member, thus allowing circulation of a liquid therethrough in the connected state, while restricting the circulation of the liquid therethrough in the disconnected state. In the connected state, a gap is generated between a prescribed part of the hollow movable valve and the valve housing in a radial direction. The hollow movable valve has a circulation opening penetrating through the prescribed part in the radial direction.
Resumen de: US2025269599A1
Systems, methods, and devices for post-processing additively manufactured objects are disclosed herein. In some embodiments, a system includes a rotor configured to support a plurality of additively manufactured objects having excess material thereon. The system can further include an actuator configured to spin the rotor so as to remove the excess material from the plurality of additively manufactured objects. The system can further include a sensor configured to obtain sensor data indicative of a cleaning status of the plurality of additively manufactured objects while the plurality of additively manufactured objects remain on the rotor. The system can further include a controller configured to adjust, based on the sensor data, an operational parameter of the rotor that enhances removal of the excess material from the plurality of additively manufactured objects.
Resumen de: WO2025178922A1
A socket preparation tool configured to facilitate autotransplantation of a donor tooth to a recipient site is provided. The socket preparation tool includes a tooth replica of the donor tooth. A coronal portion is optionally included for facilitating alignment of the tooth replica adjacent teeth during a simulated autotransplantation. A radicular portion includes a smooth surface configured to facilitate compression of soft bone or soft tissue of the tooth replica or a contoured surface adapted for filing or cutting bone of the tooth replica. A cylindrical attachment is configured to be coupled to the tooth replica, such as via a receiver. A method of guided autotransplantation of a donor tooth via the customized socket preparation tool includes at least fitting and adjusting the socket preparation tool coupled to the tooth replica in the recipient site, before extracting the donor tooth.
Resumen de: WO2025178505A1
The invention relates to a recombinant hybrid protein REC2z with a structure as defined in the description, recombinant DNA sequences encoding this protein, vectors containing the recombinant DNA sequences, and eukaryotic and prokaryotic expression systems using the in vitro recombinant DNA sequences described below. The invention also relates to the use of the recombinant hybrid protein REC2z as a component of bioink for bioprinting and also as a component of biomaterials. In addition, the invention relates to the use of recombinant DNA sequences, expression vectors and expression systems to produce the recombinant hybrid protein REC2z. The invention finds applications in bioprinting, medicine and cell and tissue engineering.
Resumen de: US2025269585A1
Methods to fabricate objects by 3D printing of poly-4-hydroxybutyrate (P4HIB) and copolymers thereof have been developed. In one method, these objects are produced by continuous fused filament fabrication using an apparatus and conditions that overcome the problems of poor feeding of the filament resulting from the low softening temperature of the filament and heat creep along the fed filament. Methods using an apparatus including a heat sink, a melt tube, a heating block and nozzle, and a transition zone between the heat sink and heating block, with the melt tube extending through the heat sink, transition zone, and heat block to the nozzle are disclosed. 3D objects are also printed by fused pellet deposition (FPD), melt extrusion deposition (MED), selective laser melting (SLM), printing of slurries and solutions using a coagulation bath, and printing using a binding solution and polymer granules.
Resumen de: WO2025179194A1
Systems and methods are provided for applying visualization features to one or more expandable members. In some embodiments, a modular rack system is provided that is configured to receive one or more expandable members. The modular rack system comprises one or more elongate rods assemblies, with each rod assembly being sized and shaped to receive a single expandable member. An inking system is configured to apply one or more visualization features on the one or more expandable members. The one or more visualization features are applied to each of the one or more expandable members such that each of the one or more expandable members has identical visualization features thereon.
Resumen de: CN120112315A
The present disclosure provides devices including a therapeutic agent coupled to a printed three-dimensional structure. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for making the device and their use, for example, in treating a condition of a subject in need thereof.
Resumen de: WO2025179212A1
Many embodiments are directed to systems and methods for 3D printing. Many embodiments utilize a print head modeled after a concentric tube robot (CTR). Certain embodiments provide a print bed allowing for collaborative printing and can include ports to allow numerous degrees of freedom from a print head without loss of a print bed solution. Further embodiments allow printing within irregular print beds, including printing within an injection mold. Certain embodiments of print heads possess multiple nozzles and/or internal tubes to allow for additional geometries. Certain embodiments are directed to print nozzles allowing for multiple material printing, and optionally on-the-fly material switching. Certain embodiments are directed to uses of bioprinting, including in vivo printing of devices, while additional embodiments allow for pipeline type printing, such that the printed part continually and/or continuously moves through a path during the printing process.
Resumen de: EP4606824A1
An object of the present invention is to provide a photopolymerization initiator that is hardly affected by inhibition by oxygen, has good photoinitiating property in air, has high sensitivity to long-wavelength light, and can suppress odor and bleed-out problems of a cured product to be obtained.A photopolymerization initiator having one or more benzophenone groups and one or more saturated or unsaturated 5 or more-membered cyclic substituents having heteroatoms in a molecule, wherein one or more saturated or unsaturated 5 or more-membered cyclic substituents having heteroatoms are bonded to one or more carbon atoms of an aryl group of one or more benzophenone groups through a carboxylic acid ester group or a carboxylic acid amide group.
Resumen de: CN120225338A
Aspects of the present disclosure include methods for making polymer structures having microvoid spaces. A method according to certain embodiments includes irradiating a polymerizable composition positioned between a build lift table and a build surface to produce such polymerizable composition, the polymerizable composition has: a polymerized region of the polymerizable composition having a microvoid space in contact with a build lift table and a non-polymerized region of the polymerizable composition in contact with a build surface; removing the build lift from the build surface; contacting the generated microvoid space with a non-reactive composition; and repeating in a manner sufficient to create a polymer structure having a clearly discernible microvoid space. Systems for preparing polymer structures according to the subject methods are also described. Also provided are polymer structures having clearly discernible microvoid spaces, such as where the microvoid spaces are filled with a non-polymerizable composition.
Resumen de: EP4606583A1
A coupling member (1) includes a valve housing (12) and a hollow movable valve (101). Relative to the valve housing (12), the hollow movable valve (101) is positionally displaced in an axis direction between a position in a connected state where the coupling member (1) is connected to another coupling member (2) and a position in a disconnected state where the coupling member (1) is disconnected from the other coupling member (2), thus allowing circulation of a liquid therethrough in the connected state, while restricting the circulation of the liquid therethrough in the disconnected state. In the connected state, a gap (G) is generated between a prescribed part of the hollow movable valve (101) and the valve housing (12) in a radial direction. The hollow movable valve (101) has a circulation opening (1010) penetrating through the prescribed part in the radial direction.
Resumen de: EP4606354A1
Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an intermedullary implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants are optimized for the expected stress applied at the bone structure site.
Resumen de: WO2024083825A1
A hollow body and a process for preparing a hollow body having a bottom, an upper end wall and side walls extending between the bottom and the upper end wall, characterized in that the upper end wall and side walls are made of metal, the cavity within the hollow body has a volume in the range between 1 picoliter to 1,000 picoliter and the upper end wall comprises at least one opening. The hollow body are suitable for encapsulating small amounts of liquid, or of very small micro-electromechanical system, may be used for the controlled release of pharmaceutical components.
Resumen de: CN120076767A
Systems, methods, and devices are provided for computer-aided design, digital treatment planning, and direct additive manufacturing of dental appliances. In some embodiments, a method includes receiving a treatment plan for teeth of a patient, the treatment plan specifying a target arrangement of teeth and a plurality of treatment stages to reposition the teeth from an initial arrangement toward the target arrangement. The method may include identifying appliance design parameters of one or more dental appliances for performing at least one of a plurality of treatment phases. The appliance design parameters may include one or more manufacturability parameters corresponding to an additive manufacturing process to be used for directly manufacturing the one or more dental appliances. The method may also include determining an appliance geometry of the one or more dental appliances using the set of appliance design parameters.
Resumen de: CN120091914A
The present disclosure relates to an aqueous bio-ink solution for light-based bioprinting applications comprising: (a) from 0.5% to 95% by weight of a water-soluble prepolymer; (b) from 0.001% to 5% by weight of a biocompatible metal acyl phosphinate photoinitiator; (c) from 0.001 wt% to 10 wt% of a biocompatible light absorber; and (d) from 5% to 99.5% by weight of a solvent. The present disclosure also relates to methods of using aqueous bio-ink solutions containing living cells and methods of using aqueous bio-ink solutions free of living cells (cell-free).
Resumen de: CN120534078A
本发明提供联结部件、流道连接机构和喷墨记录装置。联结部件包括：阀箱体；以及中空可动阀，配置在阀箱体的径向内侧，相对于阀箱体可在轴向上移位，通过在联结部件和其他联结部件被连接的连接状态时和连接被解除的连接解除状态时使中空可动阀相对于阀箱体的轴向的位置移位，从而中空可动阀在连接状态时使液体流通，而在连接解除状态时限制液体的流通，在连接状态时，在径向上的中空可动阀的预定部分与阀箱体之间产生间隙，中空可动阀具有在径向上贯通预定部分的流通口。
Resumen de: CN120531540A
本发明涉及一种熔融沉积3D打印的医疗支具，用于医疗的器具，它公开了在医疗支具的全封闭的镂空区域、半封闭的镂空区域、底座承托的镂空区域内都填充有支撑薄片，使医疗支具与支撑薄片一体成形，在医疗支具的非镂空区域阵列设置有水滴形状的通孔。本发明的优点是它能满足医疗支具3D打印支撑需求的同时，后期拆除容易，而且支撑薄片拆除对支具表面质量影响小，确保复杂结构的医疗支具与支撑薄片一体成型，使医疗支具内外表面及整体曲面造型质量更加高。
Resumen de: US2024285522A1
The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having at least one coating made at least in part using printing technologies to provide drug storage and drug release structures, notably for hydrophobic drugs and that such hydrophobic drugs can be stabilized as to hydrolysis, heat, and a combination thereof. A first aspect of the present invention includes a packaged medical device that includes at least one drug delivery contact lens. A second aspect of the present invention includes a drug delivery contact lens. A third aspect of the present invention includes a method of making a drug delivery contact lens. A fourth aspect of the present invention includes an ink. A fifth aspect of the present invention includes a method of using a drug delivery contact lens to treat or prevent a disease, disorder, or condition of the eye.
Resumen de: CN223263037U
本实用新型涉及扫描仪技术领域，具体为一种义齿3D扫描仪，包括底座、固定架、放置台、安装架和扫描装置；固定架连接底座上端，安装架连接固定架，安装架设有滑轨，扫描装置滑动连接滑轨，扫描装置上设有限位组件，限位组件与安装架配合连接；底座转动设有用于调节放置台高度的升降机构，底座设有驱动机构传动连接升降机构，底座设有用于夹持义齿的夹持机构，夹持机构位于放置台的两端。本实用新型中通过转动的放置台和夹持机构使义齿可以全方面扫描，不需要多次调节提高扫描效率。
Resumen de: AU2023365980A1
A melt electrowritten soft tissue scaffold, comprising: a first region having one or more sets of fibres and a second region having one or more sets of fibres; and an interface region joining the first region and the second region, the interface region being electrowritten along with the first and second regions in a continuous printing path, such that fibres in the interface region each join between a respective pair of fibres in the first and second regions.
Resumen de: CN120531531A
本发明公开了一种数字化和柔性压力传感器结合的大腿假肢接受腔优化制造方法。大腿残肢物理模型的数字化重建；对重建后的残肢构面数字模型空间标定和尺寸校准处理；对空间标定和尺寸校准后的残肢构面数字模型稀疏化处理并进行编辑和优化；将稀疏点云数字模型和帽檐、坐托的数字点云模型进行拼接成大腿假肢数字模型；设置柔性压力传感器压力分析调整局部片段厚度，生成外层表面形成双面稀疏点云的假肢接受腔数字模型，最后转换进行3D打印。本发明利用柔性传感单元与数字化皮肤上的点云单元相对应，进行静态和动态下肌肉受力的实时变化评估，能够在再次检查时能够快速适应患者的生理变化，提供更为个性化和及时的康复解决方案。
Resumen de: CN120531507A
本发明公开了一种牙周辅助加速正畸手术专用导板，该专用导板包括颊侧就位导板和合面就位导板、以及位于颊侧就位导板上的多个导向管，颊侧就位导板上设置有一体成型的定位销且合面就位导板上设置有一体成型的定位槽，合面就位导板套置在上颌和/或下颌的牙列上，与合面就位导板配套的颊侧就位导板上的定位销插入对应的定位槽内；所述的导向管位于牙列唇侧、牙龈软组织的外侧且排列在每个牙位的近中邻面和远中邻面处，导向管限定了支抗钉手柄工作头部的钻入位置、钻入方向和钻入深度。本发明导板使用后的创口为针状大小，患者不易出现术后水肿、强烈的炎症反应以及牙根吸收等情况，安全性强、操作方便、定位精准、费用便宜，适用于大多数正畸病例。
Resumen de: CN120531544A
本发明公开了一种基于3D打印的个性化骨骼夹板外固定装置及其制作方法，属于医疗器械技术领域。本发明包括固定主体及紧固件螺丝螺栓。所述固定主体可分为两部分，每部分纵向均设有四个调节部位。调节部位包括尼龙螺丝、尼龙螺母和底座，尼龙螺丝贯穿上下两夹板的底座连接螺母，通过旋转螺母调节夹板的松紧。所述外固定手臂夹板主体呈多边形不规则镂空状，保证了其具有较好的透气性。所述外固定手臂夹板由3D scanner扫描建模并测量具体数据，利用熔融沉积型3D打印机制成。其中3D打印机参数设置如下：控制打印喷头温度为190~220℃，打印底板温度为20~50℃，打印速度为20~40mm/s，冷却风扇转速为2000~2500rpm。打印机所使用的线材由超高分子量聚乙烯通过单螺杆挤出机制成。采用超高分子量聚乙烯保证了所述外夹板具有较高的抗冲击性能，固定效果好，有利于患者部位的稳定愈合。
Resumen de: CN120531488A
本申请提供一种基于多模态神经网络的口腔3D建模打印方法及系统，属于口腔医学技术领域，首先基于图像传感器获取目标视频，将目标视频输入训练好的第一神经网络模型，基于第一神经网络模型的输出结果，确定强磨合区域数据，最后，获取初始模型数据，将初始模型数据与强磨合数据输入训练好的第二神经网络模型，基于第二神经网络模型的输出结果，确定目标建模数据。本申请实施例提出的一种基于多模态神经网络的口腔3D建模打印方法及系统，通过动态视频中运动数据驱动3D打印模型的咬合面形态设计，在正畸治疗的过程中预判组织变化，用历史病例训练预测网络，较人工测试咬合更精准，通过预测高磨损区域并提前增材设计降低牙冠碎裂或种植体松动率。
Resumen de: EP4537787A2
Strategies that reduce shrinkage and ultimately warping of parts that are directly fabricated from photopolymer resins. This increases the accuracy of directly fabricated parts, which is essential for patient specific applications. Implementing these strategies can reduce the need for directly fabricated parts to have supporting structures, which can reduce pre-processing and post-processing steps and facilitate an easier route for production level scale of additive manufacturing.
Resumen de: AU2023375461A1
Compositions and methods for delivery of therapeutic agents to an individual in need thereof, for prevention/reduction of tissue adhesion, and for 3D printing are disclosed herein. In some embodiments, the composition comprises octadecyl modified hydroxypropyl methylcellulose (HPMC-C18) and a surfactant or cyclic polysaccharide, wherein the composition is a hydrogel that exhibits dynamic properties.
Resumen de: CN120536767A
本发明公开了一种耐蚀高超弹性增材制造镍钛合金及其制备方法与应用。所述制备方法包括增材制造成型、前处理、表面处理三个步骤。本发明采用纳秒脉冲激光重熔的方法，利用特定范围内参数优化了增材制造镍钛合金表面质量，通过纳秒脉冲激光重熔工艺的精确热物理调控，重熔层形成了细小均匀的等轴晶粒结构，而基层则保留柱状晶粒，提高了整体超弹性效应；并促使其在腐蚀过程中形成稳定的钝化膜，有效抑制基体镍释放，提高了其耐蚀性。本发明所述制备方法具有精确可控、加工效率高和适用性广的优点，适宜推广应用。
Resumen de: AU2025203084A1
Embodiments herein relate to an implant for insertion into a patient. The implant comprises a plurality of unit cells arranged to form a three-dimensional lattice structure, the three-dimensional structure comprising a resting volume of the implant. The plurality of unit cells are arranged to form a porous network of the three-dimensional structure, and wherein the three-dimensional structure is a reversibly compressible three-dimensional structure, wherein a bulk porosity of the three-dimensional structure (101) of the implant is at least 50 %.
Resumen de: CN120535735A
本发明公开了一种用于后巩膜加固的光敏树脂及其制备方法与应用。其制备方法包括以下步骤：将碳酸乙烯酯与异佛尔酮二胺混合反应生成非异氰酸酯聚氨酯；向非异氰酸酯聚氨酯加入己内酯，反应得到聚己内酯基聚氨酯二醇；在聚己内酯聚氨酯二醇溶液中添加三乙胺，再添加甲基丙烯酸酐进行反应，纯化，得到聚己内酯基聚氨酯光敏树脂。制得的聚己内酯基聚氨酯光敏树脂具有良好的生物相容性和力学性能，应用于后巩膜加压手术中，对后巩膜加压效果良好，OCT结果显示出现明显加压嵴。
Resumen de: CN120514917A
本发明涉及基于埃洛石纳米管的载药海藻酸钠水凝胶抗菌支架、制备方法及其应用，属于材料合成和生物医药技术领域。所述支架是由载药埃洛石纳米管、海藻酸钠和甲基纤维素混合依次经3D打印、交联后得到的具有一定孔隙率和孔径结构的支架，载药埃洛石纳米管包埋在海藻酸钠/甲基纤维素水凝胶，载药埃洛石纳米管是由聚乙烯亚胺修饰的埃洛石纳米管与带负电的广谱抗菌剂混合得到的。该支架兼具降解速率可控和生物相容性特点，适用于骨髓炎清创后的局部抗感染与骨再生治疗。
Resumen de: WO2024133585A1
The present invention provides a nebuliser (100) comprising one or more inputs (110), and a plurality of droplet ejectors (126) in fluid communication with the one or more inputs (110). Each droplet ejector comprises a nozzle portion and a piezoelectric actuator. The one or more inputs are for receiving one or more liquids. Each nozzle portion defines a nozzle outlet in fluid communication with the one or more inputs. Each piezoelectric actuator is operable to cause ejection of a liquid received by one of the one or more inputs through the respective nozzle outlet as one or more droplets to thereby generate an aerosol comprising the one or more droplets ejected by each droplet ejector.
Resumen de: CN120514920A
本发明公开了一种负载镁锰掺杂空位氧化铋的生物墨水及其制备方法、生物打印支架和应用，该生物墨水包括以下质量体积百分比（mg/mL）的组分：5%~15%的苯硼酸接枝甲基丙烯酰化明胶、1%~10%的聚乙烯醇、0.15%~0.3%的苯基(2,4,6‑三甲基苯甲酰基)磷酸锂、0.01%~1%的负载镁锰掺杂空位氧化铋，该生物墨水通过3D打印制备生物打印支架。本发明利用苯硼酸接枝甲基丙烯酰化明胶和聚乙烯醇为基础生物墨水材料，同时负载镁锰掺杂空位氧化铋，由其制备的生物打印支架具有良好的生物学功能，可以作为老年性骨缺损修复的骨植入物，具有重要的临床应用价值。
Resumen de: CN120514526A
本发明提供了一种基于3D打印技术的颈部理疗护具，属于医疗器械领域，所述护具由如下的部件组成：后颈托壳体、护具内衬、双震动马达、温控加热装置以及操作控制模块。所述后颈托壳体选用PLA可降解线材，创新性地融合3D打印技术与按摩理疗功能，为颈部健康护理带来全新解决方案。护具整体通过3D打印成型，能够依据个体颈部的精准扫颈部理疗护具则提升与皮肤接触的舒适度，并适应颈部日常活动。本颈部理疗护具在颈部保健、慢性颈部疾病辅助治疗以及颈部疲劳缓解等方面具有显著优势，为用户提供便捷、高效、个性化的颈部护理服务，具有广阔的市场应用前景。
Resumen de: WO2024172411A1
The purpose of the present disclosure is to provide a patient-customized helmet and a control method therefor, the helmet enabling the injection of an ultrasound contrast agent (e.g., microbubbles) into blood vessels of a patient and the radiation of ultrasonic waves into the brain by means of an ultrasound module to open the blood-brain barrier and deliver a brain disease therapeutic agent to the affected area.
Resumen de: US2025262031A1
Modular dental devices and methods of forming the same. The dental devices may include a first region having a first joining surface and a second region having a second joining surface. The first joining surface may have one or more protrusions and the second joining surface may include one or more corresponding features configured to mate with the one or more protrusions. The first and second regions may be coupled together at the first and second joining surfaces, where the one or more protrusions of the first joining surface mate with the corresponding features of the second joining surface to align the first region with the second region and to interlock the first and second regions.
Resumen de: US2025262033A1
A socket preparation tool configured to facilitate autotransplantation of a donor tooth to a recipient site is provided. The socket preparation tool includes a tooth replica of the donor tooth. A coronal portion is optionally included for facilitating alignment of the tooth replica adjacent teeth during a simulated autotransplantation. A radicular portion includes a smooth surface configured to facilitate compression of soft bone or soft tissue of the tooth replica or a contoured surface adapted for filing or cutting bone of the tooth replica. A cylindrical attachment is configured to be coupled to the tooth replica, such as via a receiver. A method of guided autotransplantation of a donor tooth via the customized socket preparation tool includes at least fitting and adjusting the socket preparation tool coupled to the tooth replica in the recipient site, before extracting the donor tooth.
Resumen de: US2025262036A1
A method according to the disclosure herein includes producing, via additive manufacturing, a first mold portion having a first recess based on a tooth portion of a patient mouth; producing, via additive manufacturing, a second mold portion having a second recess based on a gum portion of the patient mouth; positioning at least one artificial tooth in the first recess; aligning the first mold portion with the second mold portion to form a mold assembly having a cavity defined by the first recess and the second recess; filling the cavity with a resin; and removing a partial denture from the mold, the partial denture formed by the resin and the at least one artificial tooth.
Resumen de: US2025262355A1
Described are methods for producing tissue constructs, tissue constructs produced by the methods, and their use. The described method of producing a tissue construct comprises providing a granular tissue, depositing one or more filaments on or in the granular tissue, each filament comprising an ink, and gelling or fusing the granular tissue, thereby producing the tissue construct.
Resumen de: US2025262356A1
A method for treating a bone defect extending between a proximal bone structure and a distal bone structure of a patient may include resecting a region of bone between the proximal bone structure and the distal bone structure and encompassing the bone defect, positioning a biodegradable osteogenic scaffold within a biodegradable sleeve, coupling the biodegradable sleeve to a fixation member, positioning the biodegradable sleeve between the proximal bone structure and the distal bone structure, and attaching the fixation member to each of the proximal bone structure and the distal bone structure.
Resumen de: US2025262349A1
A biomaterial is provided. The biomaterial includes a methacrylated polymer-silver-containing bioactive glass (methacrylated polymer-AgBaG) in which the AgBaG is chemically coupled to the methacrylated polymer. The methacrylated polymer may include gelatin methacryloyl (GelMA). Methods of making and using the biomaterial are also provided.
Resumen de: US2025262348A1
A polymeric scaffold for bone repair and regeneration includes a body comprising a biodegradable polymer matrix and nanoparticles dispersed in the biodegradable polymer matrix, and a polydopamine surface coating on the body. A method of forming a composite scaffold for bone tissue engineering includes preparing a solution comprising a biodegradable polymer and a plurality of nanoparticles in a solvent, applying the solution to a surface of a mold and drying the solution to form a polymer matrix having nanoparticles dispersed therein, removing the mold from the polymer matrix to form an intermediate scaffold, and applying a polydopamine coating to the intermediate scaffold to form the composite scaffold.
Resumen de: US2025262351A1
A composition comprising decellularized extracellular matrices, hydrogels comprising the same, and methods of making the same are disclosed.
Resumen de: US2025265713A1
A method includes receiving a digital representation of an orthodontic aligner, analyzing the digital representation of the orthodontic aligner to identify a quality-related property of the orthodontic aligner, determining, based on the quality-related property, that the orthodontic aligner comprises a manufacturing flaw, and causing the orthodontic aligner to be remanufactured responsive to determining that the orthodontic aligner comprises the manufacturing flaw. Analyzing the digital representation includes comparing the digital representation of the orthodontic aligner with data based on a digital model of a dental arch associated with a stage of treatment to be performed using the orthodontic aligner, and calculating one or more differences between a feature determined from the data and a feature of the digital representation of the orthodontic aligner.
Resumen de: AU2024218051A1
The present invention provides a curable composition for three-dimensional stereolithography, the curable composition being used in a vat photopolymerization method and containing 100 parts by mass of a polymerizable monomer component (A), 40 parts by mass to 400 parts by mass of an inorganic filler (B) that is composed of a single kind or plural kinds of inorganic particulate matter, and 0.01 part by mass to 5 parts by mass of a photopolymerization initiator (C), wherein: 80% or more of all primary particles that constitute the inorganic filler (B) have a particle diameter of 0.05 µm to 5.0 µm; and a sample, which is formed of this curable composition for three-dimensional stereolithography and has a thickness of 0.5 mm, has a transmittance of 1.00% to 50.00% with respect to activation light. The present invention also provides a method for producing this curable composition for three-dimensional stereolithography. The present invention also provides a method for producing a three-dimensional stereolithographic model and a method for producing a dental restoration, each using this curable composition for three-dimensional stereolithography.
Resumen de: US2025262164A1
The present disclosure, in some aspects, is directed to methods of designing an oral drug dosage form formulated and configured to have a desired pharmacokinetic profile. In other aspects, the present disclosure is directed to oral drug dosage forms having a desired pharmacokinetic profile, and methods of making, such as three-dimensional printing, such oral drug dosage forms.
Resumen de: US2025262077A1
A three-dimensional subtractive manufacturing system configured for constructing an orthopedic orthosis from a first blank of a plurality of blanks includes a scanner configured to capture a 3D model of a body part of a patient, a central processor configured to receive the 3D model and select the first blank based on the three-dimensional model and a computer numerical control machine configured to receive the computer numeric control programming file and an identification of the first blank from the central processor. The central processor is configured to convert the 3D model into a CNC programming file. The CNC machine comprised of a subtractive manufacturing machine. The CNC machine configured to remove material from the first blank to form the orthopedic orthosis.
Resumen de: WO2025174829A1
A surgical tool kit and a method of installing a tissue, the method comprising positioning an alignment guide to ensure proper alignment of surgical tools relative to a lesion in a host tissue; inserting a guide pin into the host tissue to provide a reference point; using a punch to score the host tissue at the location of the guide pin; utilizing a cannulated reamer to prepare a socket in the host tissue; evaluating the prepared socket in the host tissue with a trial implant to ensure proper fit and alignment; employing an undercut tool to prepare at least one groove in the host tissue; and placing the tissue scaffold into the prepared socket using an insertion tool.
Resumen de: WO2025175303A1
A method according to the disclosure herein includes producing, via additive manufacturing, a first mold portion having a first recess based on a tooth portion of a patient mouth; producing, via additive manufacturing, a second mold portion having a second recess based on a gum portion of the patient mouth; positioning at least one artificial tooth in the first recess; aligning the first mold portion with the second mold portion to form a mold assembly having a cavity defined by the first recess and the second recess; filling the cavity with a resin; and removing a partial denture from the mold, the partial denture formed by the resin and the at least one artificial tooth.
Resumen de: AU2023361612A1
The invention relates to nerve conduits for connecting a lesioned nerve end to a target site. In particular, the invention relates to nerve conduits supporting repair of a nerve lesion and motor control and/or reducing risk of the development of a neuroma at the lesioned nerve end. Accordingly, a nerve conduit (10) for connecting a lesioned nerve end (26) to a target site (28) is suggested, comprising an elongate body (12) formed by a wall (22) and comprising a central portion (14) defining an inner cavity (16) and end portions (18, 19) defining a respective opening (20, 20') to the inner cavity (16) and arranged adjacent to the central portion (14) and at longitudinally opposing ends of the elongate body (12). One end portion (18) is configured as an insertion portion configured for inserting a respective nerve end (26). According to the invention, the other end portion is configured as a nerve end outlet portion (19), wherein an outer diameter of the wall defining the outlet portion (19) is larger than an outer diameter of the wall defining the central portion (14).
Resumen de: CN120051256A
A dental appliance for a patient includes a body including a first surface and a second surface opposite the first surface. The second surface defines a channel for receiving a plurality of teeth of the patient. The dental appliance also includes an arrangement of a plurality of features disposed on the first surface of the body. Each feature of the plurality of features includes a protrusion extending from the first surface opposite the second surface; a recess extending partially from the first surface toward the second surface; or a via extending from the first surface to the second surface. The arrangement of the plurality of features encodes feature data representing dental appliance information of the dental appliance or patient information of the patient.
Resumen de: US2025215166A1
This document describes a process of producing gel microparticles, which are consistent in size and morphology. Through the process of coacervation, large volumes of gel microparticle slurry can be produced by scaling up reactor vessel size. Particles can be repeatedly dehydrated and rehydrated in accordance to their environment, allowing for the storage of particles in a non-solvent such as ethanol. Gel slurries exhibit a Bingham plastic behavior in which the slurry behaves as a solid at shear stresses that are below a critical value. Upon reaching the critical shear stress, the slurry undergoes a rapid decrease in viscosity and behaves as a liquid. The rheological behavior of these slurries can be adjusted by changing the compaction processes such as centrifugation force to alter the yield-stress. The narrower distribution and reduced size of these particles allows for an increase in FRESH printing fidelity.
Resumen de: EP4603053A1
A removable orthodontic device, suitable to obtain complex orthodontic movements and made with CAD-CAM techniques and 3D printing, comprising an orthodontic member, made from a shape memory polymer, in turn comprising: a restraint portion of a dental arch; a connection portion which is apt to be in contact with a palatal surface and/or a lingual surface; and one or more female members positioned at said connection portion; the orthodontic device further comprises one or more temporary anchorage devices (TADs), acting as orthodontic screw, comprising a shank, a hollow upper end and a protruding head which is attached to said upper end by a respecting connection screw, said head implementing a male connection member and being made from a shape memory polymer as well; said female members of said orthodontic member and said one or more TADs being shaped as to cooperate with each other implementing an automatic pressure connection, whereby a reversible connection mechanism is implemented.
Resumen de: EP4602972A1
The present invention provides, inter alia, a method for designing an insole, comprising receiving a measurement of a foot sole associated with pressure, said measurement preferably being obtained by placing a load on a measurement surface; receiving a sole profile; determining, based on said measurement, one or more anatomical zones; determining, based on said anatomical zones, a foot profile comprising a major axis; determining, at least based on said foot profile and said anatomical zones, an interpolating surface; aligning the interpolating surface with the sole profile, to obtain an aligned 3D profile; generating, based on said aligned 3D profile, an instruction for manufacturing the insole; wherein said determining of the interpolating surface is realized according to a 3D characterization according to respective positions (y1, y2) on said major axis; wherein said determining of the interpolating surface comprises calculating, based on said foot profile and said anatomical zones, a plurality of at least two anchor coordinates (d0-d3) each lying in a respective cross-section corresponding to said respective positions (y1, y2), and calculating, based on said at least two anchor coordinates (d0-d3), an interpolating surface.
Resumen de: CN120501931A
本发明涉及组织工程生物材料领域，尤其涉及一种角蛋白基复合骨软骨的制备方法和应用，制备方法将软骨层1、钙化软骨层2和软骨下骨层3组合为复合骨软骨。软骨层1为通过静电纺丝法和发泡技术制备的角蛋白基纳米纤维气凝胶，钙化软骨层2为采用静电纺丝法制备的富含钙磷离子的角蛋白纳米纤维膜，软骨下骨层3为利用3D打印技术制备的改性角蛋白基水凝胶材料。三层结构按顺序组合形成角蛋白基复合骨软骨。所制备的角蛋白基支架具有良好的生物相容性，有利于骨细胞的粘附增殖，具有促进骨软骨修复再生的功能。
Resumen de: CN120501945A
本发明涉及一种聚醚醚酮复合材料及其制备方法和在3D打印人工颅骨修复体中的应用，涉及聚醚醚酮材料技术领域，以重量份数计，所述聚醚醚酮复合材料包括以下原料：聚醚醚酮50~60份、改性羟基磷灰石40~50份和壳聚糖4~9份。在现有聚醚醚酮/羟基磷灰石体系基础上，本发明通过采用含羧基的笼型聚倍半硅氧烷对羟基磷灰石改性并引入适宜脱乙酰度的壳聚糖，有效解决了因羟基磷灰石添加量过高导致的拉伸强度下降问题，同时改善了材料的柔韧性，获得了一种兼具高羟基磷灰石含量、优异拉伸强度和良好柔韧性的聚醚醚酮复合材料，可充分满足人工颅骨修复体等骨植入体的应用需求。
Resumen de: WO2024133585A1
The present invention provides a nebuliser (100) comprising one or more inputs (110), and a plurality of droplet ejectors (126) in fluid communication with the one or more inputs (110). Each droplet ejector comprises a nozzle portion and a piezoelectric actuator. The one or more inputs are for receiving one or more liquids. Each nozzle portion defines a nozzle outlet in fluid communication with the one or more inputs. Each piezoelectric actuator is operable to cause ejection of a liquid received by one of the one or more inputs through the respective nozzle outlet as one or more droplets to thereby generate an aerosol comprising the one or more droplets ejected by each droplet ejector.
Resumen de: CN120501942A
本发明属于组织工程支架材料技术领域，具体涉及一种磁力辅助制备成分梯度型熔体电写支架的方法。本发明将含核壳结构磁性羟基磷灰石(Fe3O4纳米颗粒和包覆在其表面的羟基磷灰石壳层)、聚己内酯和二氯甲烷的分散液干燥，得到的mHA‑PCL复合原料加热至熔融状态形成的复合熔体经线性梯度磁场处理后，进行熔体电写打印，得到成分梯度型熔体电写支架。该方法通过核壳结构磁性羟基磷灰石在线性梯度磁场中的定向迁移，实现熔体电写支架中羟基磷灰石(HA)含量呈连续线性梯度分布，模拟骨软骨组织内部存在的自然的钙化梯度结构，提升支架的仿生性能，解决传统熔体电写方法制备的支架中HA浓度突变，无法实现梯度渐变的问题。
Resumen de: CN120501928A
本发明涉及一种双向强化高稳定浆料3D打印羟基磷灰石支架的制备方法，首先根据Furnas理论计算纳米球HA和微米球HA的最佳级配比例并进行级配，其次将光固化树脂单体和稀释剂单体按照不同比例混合，加入第一分散剂和光引发剂，避光搅拌，之后将粉体与树脂进行球磨并加入第二分散剂，混合均匀得到羟基磷灰石浆料，最后将羟基磷灰石浆料使用3D打印机打印支架，对打印支架进行清洗、脱脂烧结，得到双向强化高稳定浆料3D打印羟基磷灰石支架；本发明所制备的多孔支架孔隙率为62％，抗压强度可达到14.2MPa，同时通过双重分散剂结合球形粉体协同增强浆料稳定性，能有效提高浆料的流动性和固含量，提高打印支架质量和稳定一致性。
Resumen de: CN120504796A
本发明属于生物医学工程及医用材料领域，公开了一种水凝胶组合试剂，基于水凝胶组合试剂可制备一种强韧水凝胶，所述强韧水凝胶基于全新的双网络水凝胶，其网络由PEGMA/GelNB的共价交联网络和PEGMA自交联网络组成，降冰片烯作为一种刚性结构，在凝胶网络中可以起到一种类似弹簧的作用，可以显著提升水凝胶的拉伸和压缩性能，水凝胶组合试剂制备的强韧水凝胶具有良好的生物活性和优异的力学性能，可在温和条件下快速凝胶化。
Resumen de: CN120501924A
本发明涉及一种自发电的椎间融合器及其制备方法，椎间融合器包括多孔钽支架和设置在多孔钽支架上的生物活性压电陶瓷，所述生物活性压电陶瓷包含羟基磷灰石和钛酸钡；制备方法包括以下步骤：通过3D打印制得多孔钽支架，并在多孔钽支架的上下表面预留生物活性压电陶瓷的组装位，将生物活性压电陶瓷嵌入多孔钽支架上下表面的组装位，钛酸钡和羟基磷灰石的重量比为(92～98)：(2～8)。与现有技术相比，本发明具有利用人体内机械力自发电促进椎体融合、融合器接触面力学性能匹配、提供骨生成相关离子、界面结合较好等优点。
Resumen de: AU2023361612A1
The invention relates to nerve conduits for connecting a lesioned nerve end to a target site. In particular, the invention relates to nerve conduits supporting repair of a nerve lesion and motor control and/or reducing risk of the development of a neuroma at the lesioned nerve end. Accordingly, a nerve conduit (10) for connecting a lesioned nerve end (26) to a target site (28) is suggested, comprising an elongate body (12) formed by a wall (22) and comprising a central portion (14) defining an inner cavity (16) and end portions (18, 19) defining a respective opening (20, 20') to the inner cavity (16) and arranged adjacent to the central portion (14) and at longitudinally opposing ends of the elongate body (12). One end portion (18) is configured as an insertion portion configured for inserting a respective nerve end (26). According to the invention, the other end portion is configured as a nerve end outlet portion (19), wherein an outer diameter of the wall defining the outlet portion (19) is larger than an outer diameter of the wall defining the central portion (14).
Resumen de: LU600255B1
This invention relates to a method for treating spontaneous intracerebral hemorrhage using a 3D-printed navigation guide plate combined with neuroendoscopic hematoma evacuation. The method aims to address the issue in existing technologies where relying on preoperative head CT scans for manual puncture marking on the body surface makes precise localization difficult. This innovation improves puncture accuracy, reduces surgical risks, and enhances patient prognosis. By utilizing the patient’s CT DICOM data along with 3D printing technology, the method creates a personalized navigation guide plate model. It precisely designs the puncture route and depth, ensuring accurate localization and puncture during the surgical process. Experimental results show that compared to traditional methods, this invention significantly improves hematoma evacuation rates, reduces intraoperative blood loss, shortens surgery duration, and lowers the incidence of postoperative complications.
Resumen de: EP4454601A2
The invention relates to a custom tool for forming a dental restoration in a mouth of a patient including an occlusal plane. The custom tool comprising a facial mold body for a patient-specific, customized fit with the facial side of at least one tooth of the patient, wherein the facial mold body includes a restorative portion and a first engagement portion extending away from the restorative portion, a lingual mold body for a patient-specific, customized fit with the lingual side of the tooth of the patient, wherein the lingual mold body includes a restorative portion and a first engagement portion extending away from the restorative portion. The first engagement portion of the facial mold body interlocks with the first engagement portion of the lingual mold body. The facial mold body and lingual mold body are configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of at least one tooth to be restored. The first engagement portion of the facial mold body and the first engagement portion of the lingual mold body extend generally perpendicular to the occlusal plane, and wherein either (i) the first engagement portions are sized and shaped to be adjacent the posterior teeth of the patient, and the restorative portions are sized and shaped to mate with the anterior teeth; or (ii) the first engagement portions are sized and shaped to be adjacent the anterior teeth of the patient, and the restorative portions are sized and sha
Resumen de: US2025129138A1
The present application provides a preparation method for biosynthesis of a human body structural material. A polypeptide has the amino acid sequence of SEQ ID NO. 4, 5 or 6. Recombinant type-VII humanized collagen prepared in the present application has high activity of promoting cell proliferation and does not produce an immune response when applied to a human body, and the preparation method therefor is novel and can obtain the recombinant type-VII humanized collagen on a large scale, and is widely applied in the preparation of human body structural materials.
Resumen de: US2024374359A1
A computer-implemented method for generating a color 3D model for a dental restoration. The method receives color information, a color distribution map. and shape for a tooth. The color information is assigned to the color distribution map. The color information and the color distribution map are then combined with the shape to generate a digital color 3D model. The resulting 3D model includes volumes for different color materials for the restoration to provide for color transition zones, which can be 3D printed from the 3D model to made a corresponding restoration.
Resumen de: CN119654116A
The present invention relates to a step (S01) for generating and storing, by a computer, a plurality of tooth images that are provided so as to be moved step by step in the order of orthodontic stages, a step (S02) for displaying any one of the plurality of tooth images, in which in the tooth images displayed in step S02, in order to determine the overall shape of a transparent orthodontic appliance, first a transverse reference line is provided for each tooth, and then a transverse reference line is provided for each tooth. S03, displaying the reference line, setting a cutting line of the orthodontic appliance in the tooth image displayed in the step S02 and displaying the cutting line, and displaying the semitransparent state of the transparent orthodontic appliance covering the upper tooth and the lower tooth according to the cutting line set in the step S04, and displaying the transparent orthodontic appliance according to the semitransparent state of the transparent orthodontic appliance covering the upper tooth and the lower tooth. And a step (S05) of displaying the first treatment image.
Resumen de: CN120485595A
本申请涉及金属材料增材制造技术领域，尤其涉及一种通过纳米铁粉均匀掺杂抑制β‑fleck缺陷的钛合金及其制备方法与应用。提供的钛合金材料以微米球形钛粉为基材，基材的内部均匀分布纳米铁粉；其中，以钛合金材料的总质量为100％计，纳米铁粉为0.5‑2.0wt％、微米球形钛粉为98～99.5wt％。由于纳米铁粉尺寸小、比表面积大，在激光粉末床熔融过程中快速溶解并均匀扩散至钛基体，避免了微米铁粉因扩散不充分导致的局部铁元素偏析的问题，同时纳米铁粉扩散速度快，并且避免了局部铁富集，确保无出现β相富集区(β‑fleck)和脆性TiFe析出相，有利于钛合金材料的广泛应用。
Resumen de: CN120478726A
本发明涉及材料制备技术领域，特别涉及一种用于3D打印构建组织工程皮肤的复合生物墨水及其制备方法和应用，复合生物墨水包括氧化海藻酸钠‑明胶生物墨水和AgNPs胶体溶液，氧化海藻酸钠‑明胶生物墨水通过氧化海藻酸钠与明胶构成席夫碱网络完成凝胶化。通过聚多巴胺原位还原#imgabs0#溶液，得到AgNPs胶体溶液。本发明提供的复合生物墨水具有良好的可打印性、机械性能，可用于3D生物打印；不仅拥有优秀的生物相容性还兼具自愈、抗菌、促进皮肤成纤维细胞增殖、分化的功能，可用于组织工程皮肤支架的制备，促进皮肤组织伤口愈合与功能重建，有较高的应用前景。
Resumen de: CN120478195A
本发明公开一种微藻光合治疗水凝胶面膜及其制备方法，利用悬浮浴3D打印技术与面部扫描技术，使用微藻生物墨水定制化生产3D贴合的面膜，使之在使用过程中利用光合作用产生氧气并释放有效成分，起到产氧消炎、促进细胞迁移和清除自由基来促进皮肤修复的作用，在二次交联的过程中引入小分子胶原和Se元素，促进细胞增殖与迁移，起着支撑、修复、保护的三重抗衰老作用。本发明可持续和环境友好，配方简单、设计科学，直接利用微藻、以可再生、可降解材料为原料，制备和使用过程无污染排放，原料可回收，与传统的面膜制备方式相比更加低碳环保。
Resumen de: US2024099816A1
Methods and systems are provided for diagnosing and generating a treatment plan for temporomandibular joint dysfunction where a polymeric shell appliance is utilized to generate one or more activation forces that facilitate tooth movement. The polymeric shell appliances may comprise one or more tooth receiving cavities, in which each of the plurality of tooth receiving cavities is shaped and arranged to provide a counter moment of each of the plurality of teeth.
Resumen de: CN120484471A
本发明属于生物医用材料技术领域，提供了一种聚L‑丙交酯‑己内酯复合材料及其制备方法和应用、血管支架。本发明的复合材料以聚L‑丙交酯‑己内酯（PLCL）和金属氧化物（三氧化二铁、氧化镁、氧化锌和二氧化钛中的一种或多种）为制备原料。相比PLLA，本发明的复合材料具有更好的强度和韧性；金属氧化物可以提高聚合物PLCL的降解速度。所以，本发明的复合材料兼具优异的韧性、强度和降解速度。进一步地，尤其是当金属氧化物为三氧化二铁时，所得复合材料的断裂伸长率和拉伸强度都有显著提升；且体外降解速率也有显著提升；同时，具有优异的生物相容性。
Resumen de: CN120478739A
本发明公开了一种可体温回复的形状记忆血管支架及制备方法，其制备方法包括：将聚乳酸粒料烘干后，加入PEG增韧，熔融共混，再加入聚乳酸纤维作为增强相，螺杆挤出得到复合材料，该材料相对于纯聚乳酸材料而言，提高了形状记忆材料的韧性，降低了形状记忆材料的形状回复温度，实现“人体体温”下形状回复。通过3D打印制备血管支架，本发明制得的形状记忆血管支架具有较好的回复率、固定率、更低的回复温度以及良好的生物相容性。
Resumen de: CN120478721A
本发明涉及生物医用材料技术领域，公开了一种改性聚己内酯支架及其制备方法和应用。所述改性聚己内酯支架包括由以下原料制备得到：聚己内酯、羟基磷灰石、纳米粘土和溶剂；其中，所述纳米粘土选自蒙脱石、层状双氢氧化物、凹凸棒石、海泡石、高岭土和合成型纳米粘土中的至少一种。本发明提供的改性聚己内酯支架，基于羟基磷灰石和纳米粘土的协同作用，实现了力学性能、生物活性和免疫调控功能的协同优化，支架具有接近松质骨的抗压强度，通过多级孔道结构和亲水性表面显著促进细胞粘附与迁移，羟基磷灰石与纳米粘土的协同作用不仅诱导干细胞成骨分化，还调控巨噬细胞向促修复的M2型极化，创造了利于骨再生的微环境。
Resumen de: WO2025168626A1
The invention relates to a device for producing three-dimensional screen-printed workpieces, in particular a 3D screen-printing system, comprising a printing device having a printing screen for producing at least one screen-printed workpiece layer by layer in a plurality of printing processes and comprising a metering device (18) for metering a pasty printing compound onto the printing screen, wherein the metering device has at least one container (20) for storing the pasty printing compound, a dispensing device (24) for dispensing the printing compound onto the printing screen, and a supply line (26) extending between the container and the dispensing device and supplying the printing compound from the container to the dispensing device.
Resumen de: WO2025166443A1
One aspect described herein is a method of 3D printing a tissue model in a contained volume of photocrosslinkable bioink located on a print surface. The bioink may contain living cells. The method may comprise maintaining, with the print surface, a cell viability temperature of the contained volume; locating an objective lens vertically in a bottom working plane within the contained volume and successive working planes located above the bottom working plane by moving the lens vertically relative to the surface; and in the bottom working plane and each successive working plane, moving the voxel horizontally by directing the laser beam into the objective lens at different angles at different times; focusing, with the objective lens, at each different angle and time, the laser beam into a voxel; polymerizing, with the voxel, a portion of the contained volume at each horizontal location; and moving the contained volume horizontally.
Resumen de: US2025257011A1
The invention relates to a set of chemicals for the production of a ceramic dispersion or a ceramic gel, a process for the production of a ceramic molded part and a ceramic molded part produced by this process.
Resumen de: US2025256078A1
This disclosure generally relates to devices for printing a graft onto a wound. In some embodiments, the devices comprise one or more reservoirs adapted to receive and/or contain a biological material or a synthetic material. The devices may further comprise a cooling component adjacent the reservoir configured to cool the internal portion of the one or more reservoirs at greater than or equal to −30° C. and less than or equal to 10° C., according to other embodiments. In some embodiments, the device comprises a dispenser configured to dispense the biological and/or synthetic material onto a surface of the wound. In some embodiments, the device preserves the native structure of the biological and/or synthetic material after deposition. This disclosure also provides methods for printing a graft onto a wound e.g., using the devices contemplated herein.
Resumen de: AU2024221303A1
A method and apparatus enabling additive manufacturing of individualized oral therapeutic capsule forms containing multiple medicinal ingredients, also referred to as a personalized polypill process. A process and supporting apparatus to fulfil the formulated therapy prescribed by a physician to address the medical conditions of an individual patient, furthering the practice of personalized medicine. The methods and apparatus apply to the powder forms of active pharmaceuticals, dietary supplements, and specialized chemicals, such as diagnostic inks and dyes. The methods teach the deposition of computer-controlled amounts of high-potency powder forms of active ingredients deposited in sequential layers into a single delivery form. Each active ingredient layer is sequentially deposited to a programmable dosage accurately controlled with closed-loop gravimetric sensing, enabling sub-milligram mass deposition accuracy. Cumulative doses are compacted into segregated layers of programmable density with the optional addition of an inert barrier film between each chemical entity to minimize interactions.
Resumen de: US2025256194A1
The invention relates to a multi-step method with a number of processes and sub-processes that interact to allow for the selection, design and/or manufacture of a protective sports helmet for a specific player, or a recreational sports helmet for a specific person wearing the helmet. Once the desired protective sports helmet or recreational sports helmet is selected, information is collected from the individual player or wearer regarding the shape of his/her head and information about the impacts he/she has received while participating in the sport or activity. The collected information is processed to develop a bespoke energy attenuation assembly for use in the protective helmet. The energy attenuation assembly includes at least one energy attenuation member with a unique structural makeup and/or chemical composition. The energy attenuation assembly is purposely engineered to improve comfort and fit, as well as how the helmet responds when an impact or series of impacts are received by the helmet.
Resumen de: US2025255737A1
A prosthetic assembly includes a socket and a liner. The socket includes a first interlocking feature and defines an inner volume. The liner includes a second interlocking feature. The first interlocking feature and the second interlocking feature are configured to engage each other when the liner is inserted into the inner volume of the socket. The liner is configured to receive a distal limb of a patient. At least one of the socket or the liner include inner voids extending within walls of the socket or the liner.
Resumen de: US2025255781A1
This invention relates to methods of producing 3-D printed pharmaceutical products.
Resumen de: US2025258479A1
Methods, systems, and apparatuses are described for guiding placement of transducer arrays on a patient.
Resumen de: US2025256248A1
An apparatus may be for producing nanocarriers and/or nanoformulations. A process may be for producing a nanocarrier and/or a nanoformulation with this apparatus. According to the preparation, a first liquid phase and a second liquid phase are mixed first to give a primary mixture using a static mixer. In a subsequence mixing step the primary mixture is diluted with a third liquid. An aspect of apparatus may be that the arrangement of the static mixer inside a linear pipe conducting a third liquid phase. Thus, the primary mixture exiting the mixer is instantaneously diluted with to give secondary mixture. The volume flow of the third mixture is chosen larger than the volume flow of the primary mixture. By these measures, nanocarriers with improved morphology and homogeneity are produced. Encapsulation efficiency was enhanced as well.
Resumen de: KR20250122164A
본 발명은 항균 기능성 소재인 산화아연에 실리카가 복합화된 산화아연/실리카 분말을 광경화가 가능한 아크릴 기반의 세라믹-레진에 복합화 하는 제조방법 및 이를 3D 프린팅 기술과 결합한 기술로서 궁극적으로 항균 특성을 나타내는 조성물을 이용한 치과용 임시치 구조물 제조 기술에 관한 것이다.
Resumen de: WO2024076590A2
Embodiments of an adapter, a system including the adapter, and methods of using the adapter may be for mixing a first substance and a second substance. The adapter may include a body having a first port configured to connect with a first container to receive a first substance, a second port configured to connect with a second container to receive a second substance, a third port configured to connect with a recipient container to output a mixture of the first substance and the second substance, and a mixing chamber having a first portion in communication with the first port and the second port and a second portion in communication with the third port. The adapter may further include a mixing pin inserted into the mixing chamber. In some embodiments, the mixing pin at least partially defines at least one microfluidic path for mixing the first substance and the second substance. In some embodiments, at least one of the first channel and the second channel are oriented offset of a central plane of the body.
Resumen de: US2025228647A1
An orthodontic teeth-straightener, comprising a splint element which contains, or is entirely made from, a thermoplastic polyurethane having shape-memory properties. The thermoplastic polyurethane having shape-memory properties is selected from the group of polyether polyurethanes and contains hard segments which contain polyurethane units that have been obtained by polyaddition of the isocyanate groups of a diisocyanate to the hydroxyl groups of a diol acting as a chain extender, thereby forming urethane groups. The polyether polyurethane also contains soft segments, which contain, or are entirely made from, polyether units in the form of polyalkylene glycols, wherein the polyether units are bonded to isocyanate end groups of the diisocyanate of the hard segments, thereby forming urethane groups with the hard segments. The thermoplastic polyether polyurethane is both thermo-responsive and water-responsive and thus gives the splint element dual-stimuli responsive shape-memory properties.
Resumen de: EP4599783A2
A surgical instrument comprising a jaw assembly is disclosed. The surgical instrument further comprises a motor-driven drive system configured to manipulate the jaw assembly. The surgical instrument also comprises a control system configured to control the drive system and, also, control a power supply system configured to supply electrical power to electrodes defined in the jaw assembly. In use, the surgical instrument can be used to apply mechanical energy and electrical energy to the tissue of a patient at the same time, or at different times. In certain embodiments, the user controls when the mechanical and electrical energies are applied. In some embodiments, the control system controls when the mechanical and electrical energies are applied.
Resumen de: JP2023118129A
To provide a system and method for forming a product with different size particles.SOLUTION: A system for forming a product with different size particles includes at least one print head region and at least one processor. The at least one print head region is configured to retain: a first group of print heads 106 configurable to additively print at least a first portion of a product with a first material having a first average particle size; and a second group of print heads 106 configurable to additively print at least a second portion of the product with a second material having a second average particle size. The at least one processor is configured to receive information reflective of desired properties of the product and regulate the first group of print heads 106 and the second group of print heads 106 to unevenly distribute the first material and the second material in a layer-by-layer basis to impart differing structural characteristics to differing portions of the product based on the information reflective of the desired properties of the product.SELECTED DRAWING: Figure 1
Resumen de: EP4599816A1
Vorrichtung zur Herstellung von dreidimensionalen Siebdruckwerkstücken, insbesondere 3D-Siebdruckanlage, mit einer ein Drucksieb aufweisenden Druckeinrichtung für die schichtweise Erzeugung zumindest eines Siebdruckwerkstücks in mehreren Druckvorgängen und mit einer Dosiereinrichtung zur dosierten Ausgabe einer pastösen Druckmasse auf das Drucksieb, wobei die Dosiereinrichtung wenigstens einen Behälter zur Aufbewahrung der pastösen Druckmasse, eine Ausgabevorrichtung zur Ausgabe der Druckmasse auf das Drucksieb und eine zwischen dem Behälter und der Ausgabevorrichtung verlaufende Zuführleitung zur Zuführung der Druckmasse aus dem Behälter bis zur Ausgabevorrichtung aufweist.
Resumen de: US2020015573A1
The present invention relates to a system (1) for applying at least two kinds of liquid onto respective targeted areas of a substrate (S). The system (1) includes first and second storage unit (10a, 10b) that accommodate first and second liquids (F1, F2); a pressured gas supply unit (20) that is fluidly connected to the first and second storage unit (10a, 10b); first and second applicator (30a, 30b) that are fluidly connected to the first and second storage unit (10a, 10b); and a controller (40) that is operatively connected to the applicator (30a, 30b). The pressured gas supply unit (20) causes pressure of a pressured gas to act on the liquids (F1, F2) within the storage unit (10a, 10b). The first and second applicator (30a, 30b) each include at least one nozzle (300a, 300b) disposed so as to face the substrate (S). The first and second applicator (30a, 30b) spray the first and second liquids (F1, F2) within the first and second storage unit (10a, 10b) from the nozzles (300a, 300b) toward the substrate (S) by the action of the pressured gas from the pressured gas supply unit (20). The controller (40) individually controls the first and second applicator (30a, 30b) so that the first applicator (30a) sprays the first liquid (F1) toward a targeted area for the first liquid (F1) on the substrate (S) and the second applicator (30b) sprays the second liquid (F2) toward a targeted area for the second liquid (F2) on the substrate (S). The present invention also relates to a method f
Resumen de: AU2023365980A1
A melt electrowritten soft tissue scaffold, comprising: a first region having one or more sets of fibres and a second region having one or more sets of fibres; and an interface region joining the first region and the second region, the interface region being electrowritten along with the first and second regions in a continuous printing path, such that fibres in the interface region each join between a respective pair of fibres in the first and second regions.
Resumen de: EP4599762A1
A method (10) of manufacturing a customized saddle cushion (30), such as a bicycle saddle cushion, the method comprises applying a molding paste (14) onto a saddle shell (16) to form a probe saddle (18); letting the molding paste of the probe saddle deform under a weight and motion of a rider (12) riding the bicycle during a riding session; obtaining a 2-D pressure map (22) on the geometrically stable deformed molding paste ; obtaining a 3-D saddle cushion model (21) of the geometrically stable deformed molding paste; and associating the 3-D saddle cushion model with the 2-D pressure map to obtain a 3-D saddle cushion pressure mesh (24) to be used as a reference for 3-D printing the customized saddle cushion. A density of the 3-D saddle cushion pressure mesh is correlated to the 2-D pressure map.
Resumen de: EP4600019A1
Vorrichtung zur Herstellung von dreidimensionalen Siebdruckwerkstücken, insbesondere 3D-Siebdruckanlage, mit einem Drucksieb und mit einer Rakelvorrichtung zum Fluten des Drucksiebs mit einer Druckmasse und/oder zum Pressen von Druckmasse durch das Drucksieb, wobei die Rakelvorrichtung wenigstens ein Rakelwerkzeug, eine Sensoreinrichtung zur Erfassung von auf das Rakelwerkzeug wirkenden Rakelkräften sowie eine Steuereinrichtung zur Auswertung und/oder Speicherung von Sensordaten der Sensoreinrichtung aufweist, wobei die Steuereinrichtung dazu ausgebildet ist, mittels der Sensoreinrichtung und/oder aus erfassten und/oder abgespeicherten Sensordaten der Sensoreinrichtung eine Siebrückstellkraft und/oder Siebspannung des Drucksiebs zu ermitteln
Resumen de: US2023096105A1
The present invention provides a resin composition for stereolithography that is easily shapable with good shape precision while reducing sedimentation of inorganic particles during storage, and a obtained three-dimensional shaped article thereby excels in mechanical characteristics such as flexural strength and flexural modulus, in addition to having a desirable shade and good shade stability. The present invention relates to a resin composition for stereolithography comprising a polymerizable monomer (a), a photopolymerization initiator (b), an inorganic particle (c) having an average particle diameter of 5 to 500 nm, and a hindered phenolic compound (d), wherein the content of the photopolymerization initiator (b) is 0.1 to 10 parts by mass relative to 100 parts by mass of the polymerizable monomer (a), the content of the inorganic particle (c) is 50 to 400 parts by mass relative to 100 parts by mass of the polymerizable monomer (a), and the content of the hindered phenolic compound (d) is 0.1 to 500 parts by mass relative to 100 parts by mass of the photopolymerization initiator (b).
Resumen de: US12383654B1
An acellular matrix woven material, a preparation method and an application thereof are provided. The acellular matrix woven material is prepared by combining 3D printing with weaving. At the same time, also provided are the acellular matrix woven material prepared by the preparation method and its application in preparing tissue engineering scaffold materials.
Resumen de: CN120458755A
本发明公开了一种腭侧固位骨膜下种植体支架及制作方法，种植体支架包括腭侧连接板，腭侧连接板上一侧设有螺钉孔，螺钉孔内设有固定于腭侧的螺钉，腭侧连接板上另一侧设有多个种植基台；唇颊侧连接板通过扫描数据重建患者完整颌骨结构，提取唇颊侧骨面轮廓，在三维模型中设计唇颊侧连接板的轮廓线后得到基础支架模型，然后通过三维有限元分析，对种植基台的布局结合应力分布结果以及唇颊侧的螺钉孔位进行优化，然后采用拓扑优化方法，并通过3D打印制造得到种植体支架。本发明兼具良好的力学稳定性与生物适应性，腭侧进路微创隐蔽，尤为适用于美学区及复杂骨缺损病例的修复需求。
Resumen de: CN120458785A
本发明涉及医疗器械技术领域，具体地说是一种基于仿生学原理的3D打印全踝关节假体。包括仿生脚、仿生小腿和仿生大腿，所述仿生小腿活动安装在仿生脚的外侧表面，所述仿生小腿和仿生大腿的外侧表面设置有散热机构，所述仿生大腿通过散热机构与仿生小腿构成活动连接，所述仿生大腿的内腔中设置有自适应贴合机构。本申请可以通过双面齿框啮合连接的带轴齿轮转动，带动与带轴齿轮啮合连接的半面卡尺向内滑动，通过拉杆拉动弧夹板向内进行夹持，压杆会压动第二气囊通过第二伸缩软管向弧气囊的内部进行充气，能够贴合不同大小和形状的肢体，弹力尼龙套保证了贴合时的舒适性和透气性。
Resumen de: CN120459383A
本发明公开了一种具有电磁响应骨修复多孔组织工程支架及其制备方法和应用，属于医用材料领域。本发明通过将超顺磁性纳米颗粒均匀嵌入到高分子仿生多孔支架，结合3D打印技术，构建兼具宏观力学强度与微观生物活性的分级多孔支架。利用多孔结构模拟骨细胞外基质，优化骨整合效率。同时结合支架的电磁响应特性，通过外加电磁场动态调控，诱导间充质干细胞的成骨分化并加速血管生成，通过跨学科技术融合，为临床难治性骨缺损提供一种兼具力学适配性、生物活性及智能响应性的新一代修复支架，从而实现“材料‑细胞‑微环境”三重协同修复机制。
Resumen de: CN120458756A
本发明公开了一种唇颊侧固位骨膜下种植体支架及制作方法，种植体支架包括唇颊侧连接板，唇颊侧连接板上一侧设有螺钉孔，螺钉孔内设有固定于唇颊侧的螺钉，唇颊侧连接板上另一侧为弯钩结构，弯钩结构的凸起位置设有多个种植基台；唇颊侧连接板通过扫描数据重建患者完整颌骨结构，提取唇颊侧骨面轮廓，在三维模型中设计唇颊侧连接板的轮廓线后得到基础支架模型，然后通过三维有限元分析，对种植基台的布局结合应力分布结果以及唇颊侧的螺钉孔位进行优化，然后采用拓扑优化方法，并通过3D打印制造得到种植体支架。本发明在保证刚度和耐用性的同时，整体结构更加轻便，使用的螺钉数量更少，显著提高支架的使用寿命，减少压力性损伤的风险。
Resumen de: CN120461813A
本发明公开了一种挤出和喷墨复合的3D打印方法。本发明通过挤出‑喷墨复合3D打印技术，以单液滴作为基本沉积单元，逐层堆积融合形成二维/三维高精度复杂结构。本发明实现了多种其他方法难以实现的高精度复杂结构打印，打印的二维复杂结构最小特征尺寸约50μm，三维复杂结构最小特征尺寸约80μm，并通过载细胞打印实现了体外跨尺度分级二维/三维血管网络的构建；且本发明所提供的方法可以实现高精度复杂三维结构的单步成型，避免了工艺切换带来的重复定位误差和二次加工，为解决复杂异质体外组织模型和复杂精细三维结构的制造难题提供了一种便捷有效的制造技术思路。
Resumen de: CN120458813A
本发明提供了一种双层夜磨牙口垫及其制备方法，属于医疗器械领域。本发明提供了一种双层夜磨牙口垫，由中空的GC软衬层和中空的PEEK硬质层组成，所述GC软衬层的外表面与PEEK硬质层的内表面相接触。本发明双层夜磨牙口垫的内层采用柔性生物相容材料—GC软衬层贴合牙列及软组织，极大减轻压迫感和异物感，适宜长时间佩戴，显著提升患者依从性；外层选用高强度、耐磨的PEEK，具备优异的抗咬合磨损能力和结构稳定性，特别适用于中重度夜磨牙患者的长期使用。
Resumen de: WO2024120583A1
The invention relates to a tool for use as a micromanipulator and to a method for producing the tool. The tool consists of a plurality of parts in the form of - a frame (1) which is oriented along a longitudinal axis (L) and which is arranged as a hollow body around an interior, - at least one manipulator element (2) arranged on a first end face (1.1) of the frame (1), and - at least one actuation element (3) which is arranged on a second end face (1.2) opposite the first end face (1.1) and which is mounted slidably and axially movably in the interior of the frame (1), said parts being connected interlockingly and movably to one another by means of necessary connecting and bearing elements, and the tool being entirely generated by additive manufacture, including all the necessary gaps between the parts movably connected to one another. According to the method, the tool with all its parts and with the gaps between the movable parts is manufactured entirely by additive manufacture in one processing operation.
Resumen de: CN120436817A
本申请的实施方式提供一种托槽定位导板及其设计方法和制备方法，其中，托槽定位导板用于将托槽安装在牙齿表面，具体包括第一定位导板，所述第一定位导板具有沿水平方向设置的第一定位部和与第一定位部唇颊/舌腭侧端连接并沿龈颌方向设置的第二定位部，第二定位部包括第一定位滑槽，所述第一定位滑槽具有在近远中方向的第一开口，托槽可通过第一开口进入第一定位滑槽；装配时，托槽颈部沿所述第一定位滑槽滑动并卡持在第一预定位置处，其中，在所述第一预定位置处托槽底板朝向牙齿表面，所述托槽定位导板佩戴在所述对应牙齿上时，所述第一预定位置处满足所述托槽底板与对应牙齿表面具有填充粘接剂的预留间隙。
Resumen de: CN120436842A
本发明关于一种整形外科可植入可指导软骨塑形的3D打印耳支架，涉及3D打印技术领域。包括支架本体，支架本体上设有缺口，支架本体边缘设有边缘突出部，支架本体的一侧设有反求过来的耳廓部；支架本体的下部向上回折形成钩状部。本发明能够实现高精度的耳部重建，为耳部缺损或畸形的患者提供一种创新、安全且效果优异的修复手段。
Resumen de: CN120436978A
本发明涉及3D打印技术技术领域，具体为一种基于3D打印技术的口腔靶向复合凝胶制备方法，包括低温3D打印设备，低温3D打印设备包括双通道低温挤出喷头、五轴联动运动平台和惰性环境舱；双通道低温挤出喷头包括通道一和通道二，通道一包括益生菌微囊和温敏凝胶，温度为4‑10℃，黏度为3×10³mPa·s，通道二包括白桦多肽/茶多酚光交联预聚体，含0.5%LAP光引发剂；五轴联动运动平台：打印精度±10μm，支持舌背曲面贴合，曲率半径≥2mm；惰性环境舱：氧浓度≤0.5%，温度4‑10℃，湿度30‑40%；有益效果：高活性保留与稳定性：通过惰性环境舱（氧浓度≤0.5%）与低温打印（4‑10℃），益生菌存活率提升至打印后98%，6个月储存后仍≥85%；白桦多肽降解率≤3%，显著优于传统工艺。
Resumen de: CN120436861A
本发明公开了一种桡骨远端骨折的3D打印个性化夹板及其制作方法，包括：背侧板、掌侧板、尺侧板和桡侧板，背侧板、掌侧板、尺侧板和桡侧板均为曲面形夹板，曲面的方向与桡骨形状契合；每个夹板的宽度从手腕向手肘方向逐渐增大；每个夹板的两侧均设置边缘减薄结构；每个夹板的上表面相应位置上设有多对加强筋，在每对加强筋上设有绑带限位卡扣，每对加强筋中的两加强筋之间且位于绑带限位卡扣的正下方处设有绑带下陷平台；背侧板对应位置设置有防尺侧压疮凹陷、防背侧碰撞凹陷和第一防桡侧压疮凹陷；掌侧板对应位置设置有防掌侧肌肉压迫切面；桡侧板对应位置设置有第二防桡侧压疮凹陷。本发明针对患者的个体化差异，制作出满足要求的个性化夹板。
Resumen de: CN120437373A
本发明涉及一种仿生软骨膜‑软骨及其一体化的构建方法和应用，涉及复合生物材料领域。包括如下步骤：(1)将功能性分子和聚己内酯在第一溶剂中共混，得到第一混合溶液；将所述第一混合溶液通过静电纺丝技术，构建功能性的取向纳米纤维膜；(2)采用3D打印技术，在所述功能性的取向纳米纤维膜上进行工程软骨的仿生3D打印，得到第一部分待交联的仿生软骨膜‑软骨；(3)重复步骤(2)的步骤，得到第二部分待交联的仿生软骨膜‑软骨；将两部分依次进行对合、交联反应，得到仿生软骨膜‑软骨。本发明实现了软骨膜‑软骨的仿生一体化构建，并增加其力学强度。
Resumen de: CN120436725A
本发明公开了一种牙周辅助加速成骨正畸治疗的手术导板及其制作方法，包括：根据全口牙列牙根三维数据在填倒凹后的牙列数据上设计覆盖所有目标牙及其相邻牙齿的牙冠表面的固位结构模型；在颌骨三维数据的颊侧骨面上分别设计与固位结构模型连接的第一定位结构模型和第二定位结构模型；根据全口牙列牙根三维数据在第一定位结构模型上设计线状开口区域，得到骨皮质切开线定位结构模型，并得到骨皮质切开限位导板数据和骨增量限位导板数据；基于骨皮质切开限位导板数据和骨增量限位导板数据分别进行打印，得到骨皮质切开限位导板和骨增量限位导板。本发明能够提高手术区域的定位准确度，降低手术难度。
Resumen de: KR102844656B1
본 발명은, 제작자와 환자의 대면이 어려운 상황에서도 정확한 의지 소켓을 제작할 수 있도록, 사진측량 기반 역설계 기법 및 3D 프린팅 기술을 활용한 의지 소켓 제작 방법을 제안한다. 상기 의지 소켓 제작 방법은 환자의 잔여지를 여러 각도에서 여러 번 촬영하여 사진측량 기술로 3D 디지털 모델을 획득하는 단계; 획득된 3D 디지털 모델을 기반으로 네거티브 몰드를 디자인하여 3D 프린터로 출력하고, 출력된 네거티브 몰드를 이용하여 신체 모형을 제작하는 단계; 제작된 신체 모형을 기반으로 포지티브 석고 몰드를 제작하는 단계; 포지티브 석고 몰드를 사용하여 수지(resin)로 의지 소켓을 진공 성형하는 단계; 및 진공 성형된 의지 소켓에 현가장치를 설치하는 단계를 포함한다.
Resumen de: WO2025166116A1
Disclosed are systems and methods for a computerized framework for automated ceramic inkjet printing in dental restoration manufacturing. The disclosed ceramic inkjet mesh printing for dental restorations combines precision digital control with ceramic materials to create highly accurate and aesthetically pleasing dental prosthetics. The disclosed mechanisms utilize specialized printheads designed to deposit precise amounts of ceramic materials onto dental substrates, enabling the creation of detailed color gradients and natural-looking surfaces that closely mimic natural teeth.
Resumen de: WO2025166254A1
A method for manufacturing a ceramic inkjet ink for printing on a dental material substrate includes processing solid particle components to a particle size from 0.8 to 1 μm, at a particle size distribution of D98 and adding an effective amount of additives to the solid particle components to produce the ink capable of being dispensed from an inkjet printhead onto a surface of a 3-dimensional dental material substrate having an irregular shape and uneven surfaces, while the 3-dimensional dental material substrate is simultaneously translated and rotated under the inkjet printhead.
Resumen de: WO2025165052A1
The present invention relates to a method for activating natural killer cells, comprising a step of providing electrical stimulation to natural killer cells. Specifically, electrical stimulation under predetermined conditions is applied to natural killer cells by applying an electrical stimulation system established through a 3D-printed electrical stimulation device and a function generator. Here, cancer cell-killing ability and calcium ion-mediated mechanisms are analyzed among induced intracellular effects. In addition, with respect to the natural killer cells produced according to the present invention, a method capable of enhancing the efficacy of a cell therapeutic agent without introducing genetic modification is presented, and the cells can be used to study the correlation between the cancer cell-killing ability and the intracellular calcium ion levels of electrically stimulated natural killer cells.
Resumen de: WO2025164130A1
Provided are: a curable composition for three-dimensional stereolithography, which contains 100 parts by mass of a polymerizable monomer component (A), 40-400 parts by mass of an inorganic filler (B), 0.01-5 parts by mass of a photoinitiator (C), and 0.01-2.5 parts by mass of an activation light absorber (D), and in which 10-90 mass% of the inorganic filler (B) is contained as an organic-inorganic composite filler (E), the value of light scattering index Sc serving as an index of the proportion of light scattered laterally when being irradiated with activation light is 10% or less, and the rate of transmission for activation light in a state prior to being optically cured is 1-50%; and a method for producing the curable composition for three-dimensional stereolithography. The present invention also provides a method for producing a three-dimensional stereolithographic product and a method for producing a dental restoration article, in both of which said curable composition for three-dimensional stereolithography is used.
Resumen de: AU2023361612A1
The invention relates to nerve conduits for connecting a lesioned nerve end to a target site. In particular, the invention relates to nerve conduits supporting repair of a nerve lesion and motor control and/or reducing risk of the development of a neuroma at the lesioned nerve end. Accordingly, a nerve conduit (10) for connecting a lesioned nerve end (26) to a target site (28) is suggested, comprising an elongate body (12) formed by a wall (22) and comprising a central portion (14) defining an inner cavity (16) and end portions (18, 19) defining a respective opening (20, 20') to the inner cavity (16) and arranged adjacent to the central portion (14) and at longitudinally opposing ends of the elongate body (12). One end portion (18) is configured as an insertion portion configured for inserting a respective nerve end (26). According to the invention, the other end portion is configured as a nerve end outlet portion (19), wherein an outer diameter of the wall defining the outlet portion (19) is larger than an outer diameter of the wall defining the central portion (14).
Resumen de: AU2024212880A1
An apparatus comprises a soft robotic arm and a three-dimensional (3D) bioprinter. The soft robotic arm has actuators for controlling movements of a distal end of the soft robotic arm. The 3D bioprinter is attached to the distal end of the soft robotic arm, and has a print nozzle and soft microtubule artificial muscles (SMAMs) for controlling movements of the print nozzle.
Resumen de: US2025248828A1
The Invention refers to a method for manufacturing a new prosthesis for a lower limb, the method comprising the following steps:a) Providing 3D-data of a prior inner surface of a prior socket and of ist position and its orientation relative to a component adapter, —b) Creating a 3D model of a prosthetic socket with an attachment area for a socket adapter, wherein the prosthetic socket has an inner surface based on the scanned prior inner surface and an outer surface, —c) Determining information about an orientation transmitter, —d) Manufacturing of the prosthetic socket based on the 3D model and providing the orientation transmitter based on the information, —e) Directly or indirectly connecting the manufactured socket to a component adapter by means of the orientation transmitter so that the position and orientation of the inner surface of the prosthetic socket relative to the position and orientation of the component adapter corresponds to the position and orientation of the prior inner surface of the prior socket to the component adapter.
Resumen de: US2025248902A1
The present invention relates to a curable composition for dental purposes. The invention is characterized in that the composition comprises core-shell impact modifiers and 0.1 to 10 wt. % of a binder based on long-chain mono-functional (meth)acrylic acid esters, wherein the ester group has a carbon chain with at least 3 carbon atoms. The invention also relates to the use of the composition as a dental material or a dental auxiliary material, to a dental product made of the composition, and to a method for producing the dental product.
Resumen de: US2025250522A1
A device for modelling physiological and pathophysiological states of the brain is provided. The device comprises a hydrogel with micropattern channels having a length, width and depth. The micropattern channels comprise cells selected from the group consisting of neurons, astrocytes, microglia, oligodendrocytes, neuronal organoids, cancer cells, cancer spheroids, brain tumoral cells and combinations thereof.
Resumen de: US2025252697A1
A method for fabricating a custom headwear for a subject is described. The method comprises generating a three-dimensional head data file for the subject and determining contour lines on the head; automatically generating a headwear data file. The method yet further comprises utilizing the headwear data file to generate a shape for a desired headwear, the shape having an interior configured to restrain growth of the head in first predetermined areas. Still further, the method comprises generating contour lines for the custom headwear.
Resumen de: WO2025163396A2
A system may include a donor supply sub-system configured to supply donor material to a donor substrate. The system may include a material transfer sub-system comprising a laser configured to illuminate the donor substrate via a transfer beam. The system may include an instrument head of a medical instrument configured to house the donor substrate, wherein upon an illumination of the donor substrate, the donor material is transferred to receiver material in vivo.
Resumen de: WO2025163003A1
The invention relates to a method for adapting a composite medical shoe to a human foot (1). A pressure protection element (2) serves to relieve pressure from the human foot or parts thereof.
Resumen de: WO2025163465A1
The present invention provides a method and system for fabricating complex human tissues by integrating bio-electrospraying, cell electrospinning merged with 3D multi material microfluidic bioprinting, and future additions of magnetic and acoustic levitation technologies. The fabricated tissues serve as an alternative to animal testing in drug discovery processes, aiding in the prediction of human physiological responses to various drug compounds.
Resumen de: CN120051272A
The present invention relates to a process for preparing a solid pharmaceutical administration form comprising an amorphous solid dispersion using a 3D printing process. The process is a printing process which allows the production of solid administration forms of a solid drug comprising an amorphous solid dispersion in a simple and flexible manner and makes it possible to obtain rapidly disintegrating dosage forms with high drug loading.
Resumen de: CN119789957A
The invention relates to a novel silicone foam obtained from a foamable, crosslinkable silicone composition, the invention relates to a composition comprising an organopolysiloxane having at least two silicon-bonded alkenyl groups per molecule, an organosilicon-containing compound having at least two and preferably at least three silicon-bonded hydrogen atoms per molecule, a hydrosilylation catalyst, at least one porogen as water, hydrogel or aqueous silicone emulsion, and at least one surfactant, at least one chemical blowing agent; and a linear polydimethylsiloxane.
Resumen de: WO2025165300A1
There is provided material for preventing or reducing scar formation during wound healing, the material comprising: (i) a base poly(lactic-co-glycolic acid) (PLGA); and (ii) a bioactive poly(lactic-co-glycolic acid) (PLGA) copolymer, wherein at least part of the material is in the form of a plurality of protrusions extending from a surface. Also provided are a medical device comprising said material, medical uses of said material, and a method of preparing said material.
Resumen de: WO2025166097A1
Disclosed are systems and methods of a decision intelligence (DI)-based computerized framework that automatically and/or dynamically implements a color algorithm for performing staining and glazing dental restorations. The framework operates by leveraging determined color variations through AI/ML-based analysis that generate detailed color maps, which can be translated into precise printing instructions controlling the mixture and layering of dental-grade glazing materials. A printing system can employ multiple print heads with varying base colors and opacity levels to create microscopic color gradients and translucency effects matching natural tooth enamel. The disclosed automated processing applies personalized color patterns in microscopically thin layers, ensuring consistent glaze thickness while replicating regional variations across the tooth surface. Such approach eliminates manual glazing variability while achieving superior customization compared to traditional pre-set patterns, resulting in dental restorations that integrate seamlessly with existing teeth.
Resumen de: WO2024069629A1
A 3D-printing support medium is provided herein, comprising hybrid calcium-alginate hydrogel particles and a dispersion medium, formulated by combining calcium-alginate and a soluble polymer distinct from alginate, and the dispersion medium contains a minimum of 2 mM gluconate. These hybrid hydrogel particles possess an average size ranging from 0.1 pm to 50 pm, with exceptional homogeneity characterized by a particle size distribution of less than 50% RSD, resulting in a substantially transparent medium to visible light. The support medium is provided in various forms, including drained particles and slurries with different volume ratios of hydrogel particles to the dispersion medium. The process of preparing this support medium involves forming, pulverizing, washing, and contacting the hybrid hydrogel particles with a gluconate solution, ensuring the presence of gluconate within the hydrogel matrix.
Resumen de: CN120018951A
The present invention relates to a process for the post-treatment of a 3D printed silicone article, said process comprising coating the 3D printed silicone article with a crosslinkable silicone composition comprising a microfiller. The invention further relates to a crosslinkable silicone composition comprising a microfiller, and to the use thereof as a post-treatment composition for post-treating 3D printed silicone articles.
Resumen de: CN223183653U
本实用新型属于医疗器械技术领域，涉及一种腰椎侧路锁定融合器，包括支撑主体和连接部，所述支撑主体和连接部通过3D打印一体成型，所述支撑主体外形与患者椎体终板相适应，所述支撑主体包括结构区以及贯穿结构区设置的两个植骨区，所述结构区上表面和下表面均设置有齿状结构，所述连接部上设置锁定螺钉以及与锁定螺钉配合设置的防脱件，所述连接部呈中心对称设计，且连接部的上下两端分别设置与锁定螺钉相匹配的螺钉孔，所述防脱件选用卡环，与锁定螺钉转动连接，所述锁定螺钉不突出于患者椎体外缘。本实用新型具有结构简单，操作方便，稳定可靠，能够减少手术时间，降低手术风险等优点。
Resumen de: CN120420615A
本申请提供一种近距离放疗模板打印数据确定方法。该方法通过获取目标对象待检测区域的医学影像数据，并根据医学影像数据生成原始放疗模板三维模型，然后，根据待检测区域中目标组织的受体曲面确定施源曲面上的受体区域以及扩散区域，并在原始放疗模板三维模型中生成插植针通道集合，再根据原始放疗模板三维模型以及插植针通道集合生成目标放疗模板打印数据，从而使得所确定的放疗模板打印数据在经过三维打印之后所形成的放疗模板既能利用受体区域实现对当前肿瘤组织的全面覆盖，还能够利用扩散区域实现对肿瘤组织边缘发展的预测匹配，有效地避免了重复进行医学影像采样以及放疗模板制作的复杂过程。
Resumen de: CN120420492A
一种3D打印制备甲基丙烯酰化壳聚糖/明胶基水凝胶创伤敷料的方法及应用，涉及一种制备水凝胶创伤敷料的方法及应用。为了解决现有的MXene光热转化温度高和关闭近红外照射后细菌再次迅速繁殖的问题。本发明ZGC复合水凝胶创伤敷料为多功能集成，能够同时实现止血、抗菌、抗炎、促血管化和细胞再生，尤其适合感染性创面。能够在近红外光的激活下通过光热疗法和光动力疗法的双重作用发挥抗菌性能，同时还能够与Zn2+协同发挥抗菌效果。本发明ZGC复合水凝胶创伤敷料可以通过3D打印技术根据伤口形状和深度精准定制打印，本发明复合敷料可实现精准的低温光热治疗，同时维持Zn2+持续释放和MXene物理抗菌功能，在杀灭细菌的同时保护正常组织，显著提升感染创面愈合率。
Resumen de: CN120424280A
本发明涉及水凝胶技术领域，具体涉及双重固化的水凝胶前驱体溶液、3D打印水凝胶及其应用。双重固化的水凝胶前驱体溶液包括如下重量份的原料：丙烯酸树脂0‑2份，丙烯酸单体8‑10份，热引发剂0.02‑0.05份，水溶性光引发剂0.14‑0.15份和溶剂1‑1.2份；其中，丙烯酸单体包括N‑丙烯酰甘氨酸酰胺和N‑丙烯酰氨基脲；溶剂包括磷酸盐缓冲溶液。本发明提供的水凝胶前驱体溶液制备得到的水凝胶具有优异的拉伸强度和微纳级加工精度。
Resumen de: CN120420502A
本发明公开了一种可用于逐层式光固化3D打印的水凝胶微球基生物墨水，属于生物医用和组织工程材料领域。本发明提出了一种含有可光交联的水凝胶微球与少量交联剂(微球可自交联的情况可不加)、光引发剂和光吸收剂组成的生物墨水，在逐层式光固化3D打印中通过水凝胶微球间的光交联反应形成打印结构。该类生物墨水所打印的物件由微球紧密堆积的三维结构组成，微球间的孔隙有效提高了生物墨水的细胞包载能力及生物活性，微球的模块化性可以实现打印复杂异质结构。本发明中的生物墨水具有较小的溶胀性、优秀的打印性能和负载细胞的能力，在负载细胞打印和多材料打印实验中得到了具体应用，具有良好的生物制造及组织工程应用前景。
Resumen de: CN120420518A
本发明公开了3D打印义乳的制备方法，制备步骤包括如下：S1，确定色料：该步骤主要是为确定TPE本色料的颜色。本发明通过3D打印义乳的制备方法实现一种新型的义乳制备方法，通过实现纯TPE材料的3D打印，并且在颜色、大小、形状和香味可供患者选择，从而实现了义乳的个性化定制，满足患者乳腺外观的双侧对称的美学需求，同时弥补了传统义乳按照号码生产，对于过小、过大乳房患者均无合适尺码的问题，同时通过材料的疏水特性，可有效解决透气微孔储水问题，在日常佩戴中可有效做到通风透气，避免汗液潴留，也可以扩展应用场景如温泉、游泳等，极大改善用户的生活质。
Resumen de: US2024417501A1
The present disclosure provides a photopolymerizable composition. The photopolymerizable composition includes at least one polypropylene oxide component and an initiator, plus optionally a urethane component, a multifunctional reactive diluent, and/or an inhibitor. The present disclosure also provides an article including the reaction product of the photopolymerizable composition. Typically, the article exhibits an elongation at break of 30% or greater. Further, the present disclosure provides a method of making an article. The method includes (i) providing a photopolymerizable composition and (ii) selectively curing the photopolymerizable composition to form an article. The method optionally also includes (iii) curing unpolymerized polypropylene oxide component, urethane component and/or multifunctional reactive diluent remaining after step (ii). Further, methods are provided, including receiving, by a manufacturing device having one or more processors, a digital object comprising data specifying an article; and generating, with the manufacturing device by an additive manufacturing process, the article based on the digital object. A system is also provided, including a display that displays a 3D model of an article; and one or more processors that, in response to the 3D model selected by a user, cause a 3D printer to create a physical object of an article.
Resumen de: CN120420515A
本申请涉及3D打印技术领域，具体涉及了多级仿生3D打印跨尺度复合管腔支架、制备方法及其应用。采用分级调控降解策略，总体结构模拟真实管腔组织结构，面向全生命周期满足物理性能，建立内‑中‑外复合管腔支架，内层为有序纤维层，中层为网状支撑层，外层为无序纤维层，且软组织重建后纤维层实现快速可控降解，避免阻碍内膜重建，为各种管腔疾病的治疗提供更加安全、有效和个性化的解决方案，从而显著提升患者的治疗效果和生活质量。
Resumen de: CN120420603A
本发明涉及电刺激技术领域，公开了基于3D打印面具辅助的面神经炎针灸电刺激治疗系统及方法，包括3D扫描成像设备，用于采集患者面部微观结构信息，并生成面部三维数字化模型；3D打印装置，采用三维数字化模型及大数据，设计并制造与患者面部贴合的3D打印面具；面具上设有穴位定位标识、凹槽、柔性电极及传感器矩阵；智能电刺激主控仪，通过导线与柔性电极连接，用于调控电刺激参数；云端智能决策模块，基于传感器矩阵采集的神经肌电数据，结合深度学习算法生成穴位组合方案及电刺激调控指令。上述的发明，通过对神经肌电数据的采集与深度分析，自动完成针灸穴位定位及电刺激调控，替代针灸师手工操作，实现治疗标准化，提升了治疗效率与效果。
Resumen de: CN120420503A
本发明公开了一种椎间盘髓核支架及其制备方法，属于医疗器械技术领域，其制备方法为：将PLLA、TMC和GA溶解于溶剂中，制得聚合物溶液；将聚合物溶液通过3D打印机逐层打印在冷却平台上，制得内部具有孔隙结构的八棱柱，然后将其进行干燥，制得前驱体；将前驱体进行等离子体处理，制得。该支架具有与人体自身椎间盘相似的力学性能，可减缓力学疲劳；同时，该支架的材料具有良好的生物相容性，且降解产物产生的炎症风险较小，可有效解决现有支架存在的问题。
Resumen de: CN120422391A
本发明提供了一种透超声显影的心脏制备方法，属于生物医学技术领域，包括如下步骤：S1：采集患者心脏CT造影数据；S2：建立患者整体心脏模型；S3：通过已做好的心脏模型制作对应模具，模具分为上下两部分，模具制作完成后，对模具内层进行抛光；S4：向已经抛光后的模具内灌注填充材料，使模具内填充材料固化，固化后去除模具；S5：将模具内的成品取出，并将上下两部分成品闭合连接即得所述心脏模型。本发明制得的心脏模型具有透超声显影功能，方便医生或工作人员进行操作，可广泛应用于医学上的心脏教学、临床上的手术模拟、手术培训和操作练习。
Resumen de: CN120420504A
本发明提供一种髋关节聚氨酯人工盂唇制备方法，将聚氨酯经3D打印制成圆环状聚氨酯支架，随后将圆环状聚氨酯支架表面经过聚多巴胺修饰。本发明一种髋关节聚氨酯人工盂唇制备方法，通过聚多巴胺(PDA)表面修饰技术增强其生物相容性与细胞粘附性，用于修复髋臼盂唇损伤并促进纤维软骨再生。
Nº publicación: CN120422390A 05/08/2025
Solicitante:
西安马克医疗科技有限公司
Resumen de: CN120422390A
本发明提供了一种透超声皮肤制备方法，属于生物医学技术领域，包括如下步骤：S1：采集患者平扫的胸部CT；S2：重建需要人造皮肤的位置，做出模具；S3：计算需要人造皮肤的容量，配置填充材料；S4：向模具内倒入填充材料，使填充材料固化，然后脱模，即得到透超声皮肤模型。本发明制得的皮肤模型可用在动静脉穿刺上，可以透超声，用穿刺针穿刺后不会漏水，如轻微的漏水可轻微按压漏水的位置，过1分钟左右会缓解漏水的位置，真实的模拟了人皮肤的性质，可以广泛应用在医学教学、临床上的手术模拟、手术培训和操作训练。
BOPI
Sede Electrónica
