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3-CARBONYL IMIDAZO1,5-APYRIDINE DERIVATIVES FOR USE AS CD38 INHIBITORS FOR THE TREATMENT OF CNS DISORDERS

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

GELATINASE INHIBITORS AND USE THEREOF

Resumen de: EP4714940A1

New gelatinase inhibitors, processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy and/or prophylaxis of conditions wherein inhibition of gelatinases is useful such as epilepsy, schizophrenia, Alzheimer disease, autism (in particular associated to fragile X syndrome), mental retardation, mood disorders such as bipolar disorders, depression, vascular diseases such as ischemic stroke and atherosclerosis, inflammatory diseases such as multiple sclerosis and rheumatoid arthritis, drug addiction, neuropathic pain, lung diseases such as asthma and chronic obstructive pulmonary disease, cancer and sepsis.

USE OF UROLITHIN DERIVATIVES IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Resumen de: MX2025013613A

Disclosed are methods of treating amyotrophic lateral sclerosis (ALS). Also disclosed are methods of treating C9orf72 amyotrophic lateral sclerosis (C9-ALS).

1,3-THIAZOLE AND 1,2,4-THIADIAZOLE DERIVATIVES FOR USE AS CD38 INHIBITORS FOR THE TREATMENT OF CNS DISORDERS

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

CRBN-DJ1 CRBN-DJ1 BINDING INHIBITORY PEPTIDE AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PARKINSON'S DISEASE USING THE SAME

Resumen de: KR20260039010A

본 발명은 CRBN-DJ1 결합 저해 펩타이드 및 이를 이용한 파킨슨병 예방 또는 치료용 약학적 조성물에 관한 것으로서, 보다 상세하게는 CRBN 또는 DJ1의 부분에 결합하는 펩타이드로서 CRBN과 DJ1의 결합을 저해하여 DJ1의 공급을 늘려, 응집된 α-SYN의 독성을 줄이고, α-SYN의 섬유화 및 응집을 방해하여 파킨슨 병의 예방 및 치료 효과를 갖는 약학적 조성물에 관한 것이다.

CHITINASE ANTISENSE OLIGONUCLEOTIDES

Resumen de: WO2026055750A1

The present disclosure relates to the field of oligonucleotides. More particularly, the present disclosure relates to antisense oligonucleotides for the specific binding and inhibition of translation of Chitinase (CHIT1) encoding mRNA. Additionally, this disclosure relates to methods of using such oligonucleotides in preventing or treating diseases, disorders or conditions associated with CHIT1, such as neurodegenerative or neuroinflammatory diseases, disorders or conditions like ALS.

METHOD OF TREATING AMYLOTROPHIC LATERAL SCLEROSIS

Resumen de: WO2026059890A1

The present invention is directed to a pharmaceutical composition and method for treating a subj ect diagnosed amyotrophic lateral sclerosis (ALS) with a pharmaceutical composition containing dissolved or dispersed therein a SOD1 and/or TDP-43 aggregation- inhibiting amount of a rose bengal (RB) compound that is a pharmaceutically acceptable salt of RB, RB lactone, a RB amide, an aromatic RB derivative, wherein the aromatic derivative is an ester or amide formed from an alcohol or monosubstituted amine having a 5 - or 6 -membered aromatic ring, or a 5, 6 - or 6, 6 - fused aromatic ring system that contains 0, 1, or 2 hetero ring atoms that are independently nitrogen, oxygen or sulfur. This treatment method is typically repeated a plurality of times or until the subj ect no longer needs it.

L-DOPA MICROBIOME THERAPY

Resumen de: US20260076931A1

The present invention generally provides methods and compositions for the treatment of Parkinson's disease and depression and/or anxiety. The invention relates to recombinant microorganisms, particularly gut-colonizing probiotics, modified to produce L-DOPA.

PALATABLE COMPOSITIONS INCLUDING SODIUM PHENYLBUTYRATE AND USES THEREOF

Resumen de: US20260076927A1

The present invention features palatable pharmaceutical compositions including sodium phenylbutyrate and methods for the treatment of inborn errors of metabolism (e.g., Maple Syrup Urine Disease or Urea Cycle Disorders), neurodegenerative disorders such as Parkinson's disease, spinal muscular atrophy, dystonia, or inclusion-body myositis with such compositions.

CRYSTALLINE FORM OF A PYRIDAZINE NLRP3 INHIBITOR

Resumen de: WO2026057634A1

The present disclosure relates to a compound of formula (I) which is in crystalline Form 1, characterized by having a powder X-ray diffractogram displaying peaks expressed as degree 2-Theta angles at about 3.3, 10.0, 20.1, 21.7, and 25.0. The present disclosure also relates to processes for its preparation, as well as a medicament and a pharmaceutical composition comprising it. The present disclosure further concerns the crystalline Form 1 of compound of formula (I) for use as a medicine and more particularly in the prevention and/or in the treatment of Parkinson's disease, frontotemporal dementia, multiple system atrophy, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, or brain injury.

CHIRAL GAMMA LACTAM DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PREPARATION METHOD THEREFOR

Resumen de: US20260076939A1

The present invention relates to: a method for preparing a chiral gamma lactam derivative or a pharmaceutically acceptable salt thereof by using a chiral organocatalytic compound; and a composition for preventing, alleviating or treating muscle diseases, mental diseases, or neurodegenerative diseases, comprising the derivative or the pharmaceutically acceptable salt thereof. The chiral gamma lactam derivative or the pharmaceutically acceptable salt thereof, of the present invention, has an effect of inhibiting MAO-B and MSTN, targets D1-mClu5, and can be used in the prevention, alleviation, or treatment of muscle diseases including sarcopenia, mental diseases including depression, neurodegenerative diseases including Parkinson's disease, and the like.

ANTI-PROTHROMBIN/PHOSPHATIDYLSERINE ANTIBODY, PHARMACEUTICAL COMPOSITION, AND USE

Resumen de: WO2026056971A1

Provided in the present invention is an anti-prothrombin/phosphatidylserine antibody, comprising a heavy chain variable region and a light chain variable region; the heavy chain variable region comprises HCDR1 to HCDR3 having amino acid sequences as shown in SEQ ID NOs: 1-3, respectively, and the light chain variable region comprises LCDR1 to LCDR3 having amino acid sequences as shown in SEQ ID NOs: 4-6, respectively. The anti-prothrombin/phosphatidylserine antibody of the present invention can bind to a prothrombin/phosphatidylserine complex with high affinity, thereby targeting and binding to phosphatidylserine, and has a potential therapeutic effect with respect to tumors, infections, atherosclerosis, ischemia-reperfusion injury, inflammatory bowel disease, Alzheimer's disease, Parkinson's disease, etc.

USE OF TRPM7 ACTIVATOR IN PREPARATION OF THERAPEUTIC PRODUCT FOR TREATING ALZHEIMER'S DISEASE

Resumen de: WO2026056131A1

The use of a TRPM7 activator in preparing a therapeutic product for treating Alzheimer's disease is provided. The TRPM7 activator can be a regulator of an extracellular divalent cation or a metal salt containing a divalent cation. The TRPM7 activator can retain memory and cognitive functions, protect synaptic density and reduce Aβ plaque accumulation in a mouse model of Alzheimer's disease, and the morphology and organ weight analysis of heart, liver and pancreas show that the administration of the TRPM7 activator is safe. In addition, a TRPM7 gene or a protein encoded by the TRPM7 gene can serve as a therapeutic target for treating Alzheimer's disease. A high throughput method for screening potential drug targets for treating Alzheimer's disease by screening TRPM7 activators via TRPM7 proteins broadens idea and provides a new direction for discovery and development of new agents for treating Alzheimer's disease.

5-CYANO-1H-IMIDAZOLE-2-CARBOXAMIDE COMPOUNDS AS CSF1R INHIBITORS

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

METHODS OF TREATMENT AND DIAGNOSIS OF PARKINSON'S DISEASE ASSOCIATED WITH WILD-TYPE LRRK2

Resumen de: CN121285374A

The present invention provides a method of treating a patient suffering from Parkinson's disease (PD) associated with wild type LRRK2, and a method of treating a patient suffering from Parkinson's disease (PD) associated with wild type LRRK2. The present invention recognizes that the analysis of genetic modification factors of LRRK2 in such patients allows for the identification of patients who will respond to LRRK2 inhibitors. Accordingly, the invention provides methods of identifying PD patients who will respond to LRRK2 inhibitors and methods of treating such patients.

INTRA-STRIATAL CO-TRANSPLANTATION OF AUTOLOGOUS TREG AND MDA CELLS IN PARKINSON'S DISEASE CELL THERAPY

Resumen de: WO2024233788A2

Described herein, inter alia, are compositions and methods of use (e.g., treating Parkinson's Disease and/or reducing the immune response due to needle trauma during cell transplantation) for administering a population of regulatory T (TREG) cells and/or a population of midbrain dopamine (mDA) cells to the brain of a subject.

ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

TARGETING OF MICROGLIA IN NEURODEGENERATIVE DISEASES

Resumen de: EP4710934A1

Microglial spatial heterogeneity remains a crucial yet poorly studied question in light of potential cell-directed therapies for Alzheimer's disease (AD). Little is known about the dynamics of spatially distinct microglia states, which are either adjacent or non-associated with the plaque site, and their selective contributions to neurodegeneration in vivo. So far, research has essentially focused on pathology-associated microglia. Here, we combined novel multicolor fluorescence fate mapping, single-cell transcriptional analysis, epigenetic profiling, advanced immunohistochemistry and computational modelling to comprehensively characterize the relation of plaque-associated and non-plaque-associated microglia during neurodegeneration. This approach enabled us to identify and characterize non-plaque-associated microglia as a unique and highly dynamic microglial state in a mouse model of AD. Non-plaque-associated microglia modulate network expansion, quickly adapt to environmental cues and their transition to plaque-associated microglia can be specifically modulated during disease, contrary to their reputation as a passive bystander subpopulation. This description of the dynamics of spatially segregated microglial states and their distinct molecular features may therefore open promising new avenues for state-specific therapeutic interventions during neurodegeneration.

ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

Sel de fumarate de 1-(4-amino-5-chloro-2-méthoxyphényl)-3-1-(cycloheptylméthyl)-4-pipéridinylpropan-1-one –Composition pharmaceutique et utilisation associées

Resumen de: FR3166146A1

Sel de fumarate de 1-(4-amino-5-chloro-2-méthoxyphényl)-3-1-(cycloheptylméthyl)-4-pipéridinylpropan-1-one – Composition pharmaceutique et utilisation associées La présente invention concerne un composé choisi parmi le sel de fumarate de 1-(4-amino-5-chloro-2-méthoxyphényl)-3-1-(cycloheptylméthyl)-4-pipéridinylpropan-1-one, et les hydrates de ce sel, ledit composé étant notamment à l’état de solide cristallin. La présente invention concerne également une composition pharmaceutique, comprenant en tant qu’ingrédient pharmaceuticalement actif, le composé de l’invention ainsi que le composé de l’invention pour son utilisation en tant que médicament et en particulier pour son utilisation dans le traitement d’une maladie neurodégénérative choisie en particulier parmi la maladie d’Alzheimer et la maladie de Parkinson. Figure pour l’abrégé : Néant

STABILIZED CIRCULATING PEPTIDES AND USES THEREOF

Resumen de: WO2026055173A1

The present invention provides a method for identifying a subject having a stabilized circulating peptide. The method comprises detecting the stabilized circulating peptide in a body fluid sample, for example, a serum or plasma sample, from the subject. The method may further comprise treating a neurodegenerative disease, or monitoring or adjusting a treatment of a neurodegenerative disease. Also provided is a kit. The kit comprises a binding protein that specifically binds a stabilized circulating peptide in a body fluid sample, for example, a serum or plasma sample, from a subject. The kit may further comprise an agent for detecting, treating or monitoring a neurodegenerative disease in the subject. The neurodegenerative disease may be Alzheimer disease.

METHOD OF TREATING ALZHEIMER'S DISEASE USING ANTI-N3pGlu AMYLOID BETA ANTIBODIES

Resumen de: WO2026055601A1

The invention pertains to a method for reducing amyloid plaques in the brain of a human suffering from a disease characterized by Aβ plaques in the brain. It also concerns the treatment or prevention of diseases characterized by Aβ deposition in the brain, such as Alzheimer's disease, Alzheimer's disease in Down syndrome, and cerebral amyloid angiopathy. Certain aspects of the invention involve methods, doses, or dosing regimens that decrease the risk, frequency, severity, or occurrence of amyloid-related imaging abnormalities (ARIA) in subjects undergoing the described treatments. These aspects ensure that while reducing ARIA-related issues, the methods still effectively remove amyloid β plaques from the subject's brain. Additionally, the methods, doses, or dosing regimens disclosed herein aim to reduce ARIA risks, frequency, severity, or events, in human subjects with one or two alleles of APOE4.

CARBAZOLE DERIVATIVE AND USE THEREOF

Resumen de: WO2026052031A1

The present invention belongs to the technical field of medicine. Disclosed are a pyranocarbazole derivative and a preparation method therefor, and a pharmaceutical composition thereof and the use thereof. Specifically, disclosed in the present invention are pyranocarbazole derivatives as represented by general formulas I and II. The derivative is prepared by means of artificial synthesis. Further disclosed are a pharmaceutical composition containing the derivative, and the use thereof in resisting inflammation, resisting ischemic cerebral injury, relieving pain, resisting brain trauma, treating post-stroke depression, treating vascular dementia and cerebral small vessel disease, resisting Alzheimer's disease, and treating amyotrophic lateral sclerosis.

MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88

Nº publicación: WO2026055419A1 12/03/2026

Solicitante:

ACADIA PHARMACEUTICALS INC [US]
ACADIA PHARMACEUTICALS INC

Resumen de: WO2026055419A1

N-(1,1'-biaryl-4-yl)-N-((1-hydroxycycloalkyl)methyl)-2-(aryl)cyclopropane-1-carboxamide compounds (I) and derivatives are G-protein coupled receptor (GPR) 88 modulators for use in the treatment of a disease mediated by GPR88. Indications include Tourette's Syndrome, Huntington's Disease (HD), Addiction, Parkinson's Disease (PD), Schizophrenia, and Attention Deficit Hyperactivity Disorder (ADHD), choreiform movements, tardive dyskinesia, speech delay, learning disabilities, depression, hyperkinetic movement disorders characterised by chorea and/or dystonia, psychosis, cognitive deficits in schizophrenia, affective disorders, bipolar disorder, Alzheimer's disease, basal ganglia disorders, and tardive dyskinesia.