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一种使用前驱液光固化3D打印的立方体镂空结构及其应用

Resumen de: CN119910896A

本发明属于健康医疗技术领域，涉及一种使用前驱液光固化3D打印的立方体镂空结构及其应用，立方体镂空结构呈正六面体状，棱长为600～800微米、镂空度为25～35％，泊松比为0.425～0.525，立方体镂空结构设有贯穿的圆形气孔，圆形气孔的孔径为200～400微米；立方体镂空结构的成分包括：海藻酸钠SA、丙烯酰胺AM、丙烯酸甲酯ACMO；本发明立方体镂空结构增加了材料柔韧性和透气性，对脉搏跳动等微小形变更加敏感；内部结合保证了材料力学性能不受影响，经过多次循环工作后，仍保持信号输出的稳定性，没有明显的峰值衰减或初始电阻偏移，有效提升了传感器的长期监测能力和可靠性，解决了传统应变传感器依赖纳米填料提升灵敏度而导致抗疲劳性能不佳的问题。

一种义齿数字化上瓷方法

Resumen de: CN119908866A

本发明涉及口腔修复技术领域，特别涉及一种义齿数字化上瓷方法。数字化上瓷的方法包括数字化扫描、数字化设计、数字化制造、高温烧结、数字化上瓷、烤瓷、自动抛光、质量检测。本发明通过采用数字化技术和自动化设备，实现义齿烤瓷冠上瓷过程的自动化，由自动上瓷机（上瓷机器人）进行（喷涂）上瓷操作，上瓷颜色计算机自动调制，保证了上瓷结果的颜色、形态等要求与设计一致，不再需要人工堆砌，并且减去了车瓷的流程，从而提高生产效率，降低人工劳动强度，提高制作精度和舒适度，产品质量精准可控；实现了义齿烤瓷冠上瓷过程的自动化，降低了人工劳动强度，提高了生产效率和制作精度。

一种氧化锆种植体表面促成骨和抗菌磷酸锌涂层的制备方法及装置

Resumen de: CN119912258A

本发明属于齿科种植体领域，尤其涉及一种氧化锆种植体表面促成骨和抗菌磷酸锌涂层的制备方法及装置，磷酸涂层的制备步骤包括：S4：取氧化锌、磷酸、硝酸和去离子水混合，并加入添加剂制备磷化液；S5：将磷化液和氧化锆种植体置于反应釜内，反应釜置于150～230℃的烘箱内加热3～12h，待自然冷却后取出；S6：采用去离子水超声清洗1～5min，并置于40～60℃的烘箱干燥，最后得到覆载磷酸锌涂层的氧化锆种植体；通过运用水热法在氧化锆牙种植体表面制备磷酸锌涂层，通过改变磷化液配方和调节水热反应的温度和时间，具备良好力学性能、细胞相容性、成骨性能和抗菌性能，对于拓展氧化锆陶瓷种植体材料在口腔领域的临床应用具有重要的意义。

一种具有促进细胞增殖能力的3D打印钛合金植入物及其制备方法和应用

Resumen de: CN119909227A

本发明公开了一种具有促进细胞增殖能力的3D打印钛合金植入物及其制备方法和应用，属于骨修复技术领域。本发明提供的水凝胶具有多孔结构，可以提供营养和氧气运输，利于细胞渗透和增殖，从而促进新组织的形成，为骨骼生长成多孔材料提供空间；提供的3D打印钛合金植入物凝胶涂层与3D打印钛合金间通过氨基和羟基间的氢键连接，结构紧凑，结合稳定性高；制备的水凝胶热具有良好的热稳定性、拉伸性、抗氧化性、抗菌性能和溶血性能，同时溶胀性小，降解性能优异，无细胞毒性，使3D打印钛合金植入物不会受身体温度的影响，适于骨修复。

一种宠物犬用关节护具的3D打印制备方法

Resumen de: CN119910909A

本申请涉及医疗器械技术领域，公开了一种宠物犬用关节护具的3D打印制备方法，包括以下步骤：S1、数据测量：测量宠物大腿围、膝关节围、小腿围、脚围、大腿长、小腿长和脚长的尺寸数据；S2、3D建模：分析测量尺寸数据，基于患犬关节部位的信息，建立关节护具的初步三维模型；S3、定向设计：根据关节特点，增加允许关节活动的设计，建立最终的三维模型；S4、输出打印：将三维模型输入到3D打印设备，一体打印得到完成品的关节护具。通过多样化的数据获取方式，结合3D软件建模技术，能够使护具形状精准匹配宠物犬的腿型，从而实现最佳的固定效果，适应不同用户需求，并且支持远程取模制作护具，提升了制作的灵活性。

HYDROGEL COMPOSITION FOR 3D PRINTING AND METHOD FOR FABRICATING ARTIFICIAL BLOOD VESSEL USING SAME

Resumen de: WO2025089835A1

The present invention relates to a hydrogel composition for 3D printing and a method for fabricating an artificial blood vessel, using same, the hydrogel composition comprising a granular hydrogel and a matrix hydrogel solution, wherein the matrix hydrogel solution includes an acrylamide-based compound, a compound containing at least two hydroxyl groups, a crosslinking agent, an initiator, and a solvent.

ARTIFICIAL BLOOD VESSEL MANUFACTURING APPARATUS AND ARTIFICIAL BLOOD VESSEL MANUFACTURING METHOD USING SAME

Resumen de: WO2025089876A1

The present invention relates to a technology for manufacturing an artificial blood vessel and, more specifically, to a technology for manufacturing an artificial blood vessel by a 3D printing technique using hydrogel ink. In addition, the purpose of the present invention is to provide a training artificial blood vessel manufacturing apparatus capable of manufacturing an artificial blood vessel having physical properties similar to those of an actual blood vessel by presenting extrusion and curing conditions of hydrogel ink optimized for a 3D printing technique for manufacturing the artificial blood vessel.

METHOD FOR MANUFACTURING SMALL-DIAMETER BIORESORBABLE ARTIFICIAL BLOOD VESSEL BY USING DISCHARGE METHOD AND SMALL-DIAMETER BIORESORBABLE ARTIFICIAL BLOOD VESSEL MANUFACTURED THEREBY

Resumen de: WO2025089466A1

Provided are a method for manufacturing a small-diameter bioresorbable artificial blood vessel by using a discharge method, and a small-diameter bioresorbable artificial blood vessel manufactured thereby. The method comprises the steps of: discharging an artificial blood vessel using a bioresorbable material; physically crosslinking the discharged artificial blood vessel; and chemically crosslinking the physically crosslinked artificial blood vessel.

Vascular Implant

Resumen de: US2025134642A1

A vascular implant including a tubular body of a polymeric material. The body has opposed filter body ends and a longitudinal axis. The body has a generally tubular segmented side wall that includes multiple spaced apart wall panels surrounding a central open-ended bore. The body includes one or more filtering elements in the bore and in between filter ends. One or more filtering elements including a hub at the central longitudinal axis and multiple radially extending filtering arms extend radially between the hub and wall, wherein each arm connects to a wall panel. The tubular body end has anchors that prevent migration and/or tilting.

MICROFLUIDIC-BASED FIBER FORMATION METHODS AND SYSTEMS

Resumen de: US2025135723A1

Microfluidic-based fiber formation methods and systems employ a computer vision and deep learning system and method to enable contactless sensing, analysis, and monitoring of key operational parameters within microfluidic crosslinking printheads on 3D bioprinters. Embodiments may employ object detection and/or semantic segmentation to facilitate the sensing, analysis, and monitoring. Deep learning can employ convolutional neural networks to localize and analyze the flow of different biological materials within the microchannels as well as to identify the operation of various microfluidic printhead on-chip components that can impact final quality of printed tissues. Printed tissues can include single-material fibers, including hollow filorezbers, as well as more complex coaxially-layered fibers.

STEREOLITHOGRAPHY PLATE DENTURE MANUFACTURING KIT, AND METHOD FOR MANUFACTURING PLATE DENTURE

Resumen de: US2025134636A1

The present invention relates to a plate denture production kit for stereolithography including a curable composition for a denture base (I) containing a (meth)acrylic based polymerizable monomer component (A) containing a (meth)acrylic based polymerizable monomer (m) as a major monomer, and a photopolymerization initiator, and a composition for a prosthetic tooth (II) containing a (meth)acrylic based polymerizable monomer component (B) containing the same (meth)acrylic based polymerizable monomer (m) as contained in the curable composition for a denture base (I), having a content of the (meth)acrylic based polymerizable monomer (m) of 20% by mass or more based on 100% by mass of the (meth)acrylic based polymerizable monomer component (B), and a method of producing a plate denture.

BIOREACTOR SYSTEM

Resumen de: WO2025087952A1

The present invention relates to a biofabrication system for bioprinting and/or patterning three dimensional scaffold and retention structures using biofilm producing bacteria as the means of synthesizing geometries. The machine comprises a negative mobile mold of the final three dimensional shape desired and one or more oxygen blocking floaters to allow biofilm growth only in the positive part of the aforementioned mold. The bioprinter movement is calibrated relative to the culture medium surface level to maintain continuous biofilm growth. The bioreactor may be used along with the ability to control temperature, humidity, air flow and culture media conditions and nutrients as the three dimensional synthesis requires.

A DENTAL ABUTMENT FOR ANCHORING A DENTAL APPLIANCE

Resumen de: WO2025088134A1

The present invention relates to a dental abutment and assembly for anchoring a dental appliance comprising means addressing, by allowing lateral and angular movements, deviation from tolerance generated at an interface between the dental abutment and a dental appliance produced by additive or subtractive manufacturing.

HOLOGRAPHIC VOLUMETRIC ADDITIVE MANUFACTURING (HOLOVAM)

Resumen de: WO2025088142A1

The invention relates to a method for volumetric additive manufacturing (VAM) using holography for 3D printing an object, and a corresponding VAM system. The method includes determining a composite hologram, and performing a phase and/or spatial light modulating of a coherent input beam, such as a laser, based on the composite hologram and directing the spatially and/or phase modulated beam towards the reconstruction space to generate a pixelated projection in the reconstruction space, the pixelated projection being applied for printing the 3D object, for example using a photocurable resin. The invention provides improved resolution, speed, and/or light efficiency, in particular with respect to 3D printing of biological/medical objects, such as biocompatible implants, such as organs or parts of organs.

COMPOSITION FOR 3D TISSUE CULTURE

Resumen de: US2025136927A1

The invention relates to a composition for preparing a 3D scaffold for culturing cells and tissue, such as human cells and tissue. In particular embodiments, the present invention relates to a composition comprising a biocompatible polymer suitable for the preparation of a hydrogel, and a modified extracellular matrix (ECM) protein that is unreactive towards the biocompatible polymer, such that, after preparation of a hydrogel, the modified ECM protein is not covalently bound to the hydrogel. Compositions of the invention are suitable for use in 3D bioprinting, tissue engineering, drug screening, disease modelling and methods of treatment such as tissue regeneration.

PATIENT-SPECIFIC IMPLANT AND METHOD FOR ITS MANUFACTURE

Resumen de: US2025135169A1

The invention relates to a patient-specific implant (5) for insertion into a body cavity of a patient, for example into the round window niche of the middle ear. The invention also relates to a method of manufacturing such an implant (5).

NASAL CANNULA COVER

Resumen de: US2025135142A1

A nasal cannula cover comprising two cooperative portions which may be when not in use “snapped together” while one portion remains moveably affixed to the cannula and moveably stored just above “a plastic cuff” commonly used to tighten/loosen the cannula. In certain embodiments, the nasal cannula cover can be attached to a user's ears.

Articulating Medical Stand

Resumen de: US2025137271A1

An inventive articulating medical stand comprises a lower horizontal support member, a vertical support member, an upper horizontal support member, a tray mounting member and an adhesive medical tray member. The vertical support member is connected to the lower horizontal support member and is capable of vertical height adjustment, and optionally axial rotational adjustment. One end of the upper horizontal support member is connected to the vertical support member and is capable of axial rotational adjustment. The tray mounting member is slideably connected to the upper horizontal support member and is capable of linear adjustment along the longitudinal length of the upper horizontal support member. The tray mounting member is also capable of angular rotational adjustment with respect to the longitudinal axis of the upper horizontal support member. The adhesive medical tray member is removably connected to the tray mounting member and comprises a releasably adhesive component for attachment of medical items. Accordingly, the articulating medical stand is configured such that the adhesive medical tray member can be adjusted through all axes of dimension.

MEW TISSUE SCAFFOLD

Resumen de: AU2023365980A1

A melt electrowritten soft tissue scaffold, comprising: a first region having one or more sets of fibres and a second region having one or more sets of fibres; and an interface region joining the first region and the second region, the interface region being electrowritten along with the first and second regions in a continuous printing path, such that fibres in the interface region each join between a respective pair of fibres in the first and second regions.

DEVICES WITH LUMINA FOR BONE IMPLANTATION

Resumen de: AU2023371660A1

Provided herein are medical devices and methods for treating bone fractures. The medical device comprises a body with a proximal end and a distal tip, housing a scaffold with a porous structure distributed in proximal and distal lattices. The device includes an upper lumen in fluid communication with a first opening at the proximal end, and a lower lumen in fluid communication with a second opening at the proximal end. The device is configured to support independent delivery of cement and cells to the lattices. In some embodiments, the device is a bone screw with a thickened head-neck junction, designed to reduce the likelihood of rod breakage during installation. The methods involve implanting the device into a patient's bone, providing an innovative approach to fracture treatment.

BONE HARVESTING DEVICES FOR BONE IMPLANTATION

Resumen de: AU2023371661A1

Provided herein are medical devices and methods for treating bone fractures. The medical device comprises a body, a scaffold within the body, and a means for focusing bone growth throughout the body. The device is designed to minimize shear stresses on a distal tip and distribute micromotion to encourage bony ingrowth. The scaffold may include a triply periodic minimal surface (TPMS) with a cubic repeating pattern defining walls within the scaffold, and the TPMS may be helically wrapped around a central axis of the device. The device may also house biologic agents and accommodate an autologous product. In some embodiments, the medical device is a bone screw or a pedicle screw, designed to reduce common issues such as screw loosening, screw backout, and rod breakage. The method of treatment involves implanting the medical device into a patient's bone to aid fracture healing.

POLYMERIC STRUCTURES HAVING A MICRO-VOID SPACE AND SYSTEMS AND METHODS FOR MAKING SAME

Resumen de: AU2023364836A1

Aspects of the present disclosure include methods for making a polymeric structure having a micro-void space. Methods according to certain embodiments include irradiating a polymerizable composition positioned between a build elevator and a build surface to generate a polymerizable composition having a polymerized region of the polymerizable composition having a micro-void space in contact with the build elevator and a non-polymerized region of the polymerizable composition in contact with the build surface, displacing the build elevator away from the build surface, contacting the generated micro-void space with a non-reactive composition and repeating in a manner sufficient to generate a polymeric structure having a resolved micro-void space. Systems for preparing a polymeric structure according to the subject methods are also described. Polymeric structures having a resolved micro-void space such as where the micro-void space is filled with a non-polymerizable composition are also provided.

IMPROVED SILICONE PROSTHETIC LINERS AND METHODS OF PRODUCING SAME

Resumen de: WO2025090560A1

Methods for selective matting of some, but not all, surfaces of a silicone article of manufacture are disclosed. By use of a silicone matting additive and manipulation of process variables, a silicone article of manufacture may be produced that comprises some surface areas that exhibit silicone's inherent tacky texture and other surface areas that exhibit a matted texture. In an exemplary embodiment, a silicone prosthetic liner may be produced where an interior surface is taky and an exterior surface is matted.

THREE-DIMENSIONAL ENGINEERED LYMPHATIC AND ASSOCIATED TISSUE GRAFTS

Resumen de: WO2025091008A1

Described herein are methods of use involving tissue mimicking compositions comprising hydrogel systems and at least one therapeutic agent

BIODEGRADABLE NANOCOMPOSITE INK FOR 3D PRINTING RADIOPAQUE SCAFFOLDS

Nº publicación: WO2025091000A1 01/05/2025

Solicitante:

NORTHWESTERN UNIV [US]
NORTHWESTERN UNIVERSITY

Resumen de: WO2025091000A1

Provided herein are biodegradable nanocomposite inks for 3D printing of radiopaque scaffolds. In particular, X-ray visible, radiopaque, and photocurable liquid polymer-ceramic inks are provided comprising a composite of metal oxide nanosheets and acrylated/methacrylated polydiolcitrate polymers.