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Resultados 56 resultados
LastUpdate Última actualización 30/11/2025 [07:17:00]
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Solicitudes publicadas en los últimos 60 días / Applications published in the last 60 days
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METHODS TO DETECT AB PROTEOFORMS AND USE THEREOF

NºPublicación:  US2025306037A1 02/10/2025
Solicitante: 
WASHINGTON UNIV [US]
Washington University
WO_2023220276_PA

Resumen de: US2025306037A1

The present disclosure relates to methods useful to identify subjects having an increased risk for conversion to mild cognitive impairment (MCI) due to Alzheimer's disease (AD) and/or stage a subject prior to the onset of mild cognitive impairment (MCI) due to Alzheimer's disease (AD) and/or identify subjects with Aβ amyloidosis and/or to identify subjects who should or should not undergo further testing or treatment for Aβ amyloidosis, as well as methods for treating subjects diagnosed with Aβ amyloidosis by the methods disclosed herein.

DEVICE AND METHOD FOR THE DETECTION OF BIOMARKERS ASSOCIATED WITH NEURODEGENERATIVE DISEASES

NºPublicación:  US2025305982A1 02/10/2025
Solicitante: 
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECN CONICET [AR]
UNIV NACIONAL DE TUCUMAN [AR]
SIST PROVINCIAL DE SALUD DE TUCUMAN [AR]
SKYBIO LLC [US]
UNIV DE BUENOS AIRES [AR]
CONSEJO NACIONAL DE INVESTIGACIONES CIENT\u00CDFICAS Y T\u00C9CNICAS (CONICET),
UNIVERSIDAD NACIONAL DE TUCUM\u00C1N,
SISTEMA PROVINCIAL DE SALUD DE TUCUM\u00C1N,
SKYBIO LLC,
UNIVERSIDAD DE BUENOS AIRES
JP_2025522643_A

Resumen de: US2025305982A1

The present disclosure provides devices for the detection and/or quantification of neurotoxic amyloid-type protein aggregates, comprising a doxycycline derivative immobilized on an appropriate surface, as well as electrochemical and immunochemical methods associated to the use of such devices.

Method of producing and preparation of exosomes (nestaexo) derived from human immature dental pulp stem cells for therapeutic applications

NºPublicación:  IL322642A 01/10/2025
Solicitante: 
AVITA INT LTD [VG]
FUNDA??O BUTANTAN [BR]
KERKIS IRINA [BR]
ARALDI RODRIGO PINHEIRO [BR]
AVITA INTERNATIONAL LTD,
FUNDA??O BUTANTAN,
KERKIS Irina,
ARALDI Rodrigo Pinheiro
IL_322642_A

Resumen de: WO2024166074A1

The present invention relates to a method of isolating exosomes from human immature dental pulp stem cell (hIDPSC) cultures that is scalable. The present invention also provides pharmaceutical compositions comprising exosomes and methods of using these pharmaceutical compositions to treat a neurological disease or condition, infectious disease, or cancer.

超分子ポリマー治療および診断

NºPublicación:  JP2025532621A 01/10/2025
Solicitante: 
ザリージェンツオブザユニバーシティオブカリフォルニア
JP_2025532621_PA

Resumen de: US2024197682A1

A method of inhibiting propagation of protein misfolding associated with a neurological disease, is carried out by contacting an environment populated with a propagating amyloid conformation of a protein (prion) associated with a neurological disease with molecules which binds multiple adjacent sites of the protein assemblies and allowing the molecules to bind multiple cites of the protein assemblies; and thereby impeding propagation of the disease-associated conformation of the protein in the environment. Drug/prion complexes are formed and uses of the drugs in detection and treatment of neurodegenerative diseases are disclosed.

Compounds and methods targeting human tau

NºPublicación:  IL322784A 01/10/2025
Solicitante: 
ELI LILLY AND COMPANY [US]
ELI LILLY AND COMPANY
IL_322784_A

Resumen de: CN120559249A

The present invention provides compounds and methods for targeting human tau, particularly human tau phosphorylated at threonine 217 and tau isoforms expressed only in CNS, including therapeutic antibodies, pharmaceutical compositions and diagnostic applications for use in the field of neurodegenerative diseases such as AD, PSP and FTD.

ANTICUERPOS ANTI-PROTEÍNA A-b, MÉTODOS Y USOS DE ESTOS

Nº publicación: AR133487A1 01/10/2025

Solicitante:

F HOFFMANN LA ROCHE AG [CH]
F. HOFFMANN-LA ROCHE AG

TW_202513585_A

Resumen de: TW202513585A

Herein is reported an antibody that binds to human A-beta protein, wherein the antibody comprises a heavy chain variable domain (VH) and a light chain variable domain comprising CDRs selected from (1) CDRs of SEQ ID NO: 85, 86, 87, 81, 82 and 83; or (2) CDRs of SEQ ID NO: 85, 89, 87, 81, 82 and 83; or (3) CDRs of SEQ ID NO: 85, 86, 87, 81, 82 and 91; or (4) CDRs of SEQ ID NO: 85, 89, 87, 81, 82 and 91.

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