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273
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Última actualización
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Resultados 175 a 200 de 273
Resumen de: WO2026063647A1
The present invention relates to an antibody specifically binding to TDP-43 and use thereof. When the antibody of the present invention is used, the level of TDP-43, particularly TDP-43 aggregates, can be effectively detected. Therefore, the present invention can be a powerful tool for distinguishing TDP-43 proteinopathy from other clinically similar neurodegenerative diseases and diagnosing TDP-43 proteinopathy, serving as a biomarker for TDP-43 proteinopathy, including FTD, ALS, LATE, and the like.
Resumen de: WO2026064356A2
Mismatch anchoring compounds (MACs) are disclosed that recognize and bind to specific base-pair mismatches (mmBP) present within single stranded or double stranded DNA, RNA, and oligonucleotide sequences, and enable the ex vivo identification of DNA/RNA point mutations (DNAPM/RNAPM), including disease-associated, rare, and low abundance DNAPM/RNAPM, and the isolation and elimination of mmBP-positive cells. The use of MACs in vitro and in vivo (a) blocks mmBP-positive DNA replication and gene transcription/expression, (b) inhibits mmBP-positive cell proliferation, (c) reverses, prevents, and/or treats mmBP-rnediated disease, aging, and age-related disorders, (d) blocks mmBP-positive RNA and/or RNA-DNA duplex translation and inhibits the production of abnormal disease-causing proteins, (e) silence mmBP-positive genes, and (f) blocks intracellular pathogen replication. MAC-conjugates and their uses are disclosed, including MACs radiolabeled with SPECT/PET/particle-emitting isotopes for radioimaging and/or radiotherapy of mmBP-positive diseases.
Resumen de: WO2026062142A1
The invention relates to a circuit carrier (2), PCB, for a clip (1) for mounting on an absorbent article (4). The circuit carrier (2) comprises an impedance and electrochemical sensing module (21) configured to obtain a first measurement signal, a gas sensing module (22) configured to obtain a second measurement signal, a motion and position sensing module (23) configured to obtain a third measurement signal, a temperature sensing module (24) configured to obtain a fourth measurement signal, and a main controller (29) configured to control an operation of the sensing modules (21, 22, 23, 24) for obtaining the measurement signals, to sample and process the obtained measurement signals from the sensing modules (21, 22, 23, 24) and determine an output based on the sampled measurement signals, wherein the main controller (29) comprises a communication unit configured to exchange the measurement signals and/or the determined output with an external device and/or a server using an radio-frequency, RF, module, a gateway and a wireless personal area network transmission, WPAN, protocol, and/or using serial data transmission. The invention further relates to a clip (1) comprising the circuit carrier (2) according to the invention.
Resumen de: DE102024127976A1
Eine mikrofluidische Vorrichtung (12) zum Probenauftrag einer Körperflüssigkeit auf ein konditioniertes Sensorelement für eine Detektion von molekularen Biomarkern in der Körperflüssigkeit und/oder zum Konditionieren des Sensorelements (14) mittels eines Konditionierungsfluids umfasst zumindest eine Interaktionskammer (40), die abschnittsweise durch ein Sensorelement (14) geschlossen ist. Eine Pneumatikeinheit (70) ist mit der zumindest einen ersten Aufnahme (46) verbunden und dazu eingerichtet, diese mit Überdruck zu beaufschlagen und die Körperflüssigkeit oder das Konditionierungsfluid durch die zumindest eine Interaktionskammer (40) entlang der behandelten Oberfläche (16) einmalig und unidirektional und anschließend in den zumindest einen Entsorgungsbehälter (52) zu pumpen, so dass bei Körperflüssigkeit Biomarker an der Oberfläche (16) haften oder bei Konditionierungsfluid die Oberfläche konditioniert ist. Ferner werden eine Biomarkerdetektionsvorrichtung (18) und eine Verfahren zum Probenauftrag einer Körperflüssigkeit auf ein konditioniertes Sensorelement (14) für eine Biomarkerdetektion und/oder zum Konditionieren eines Sensorelements (14) für eine Biomarkerdetektion vorgeschlagen.
Resumen de: WO2026064744A1
The subject invention provides materials and methods for treating diseases affecting the central nervous system (CNS) and/or other viral reservoir organs utilizing nanoscopic diamond particles, i.e., nanodiamonds (ND), loaded with drug molecules and microglial targeting moiety.
Resumen de: US20260086100A1
0000 Provided are methods of determining risk for chronic stress and stroke. More specifically, provided is an early prognostic index that can be used to predict chronic stress and stroke risk. There is provided a method of evaluating the risk of developing chronic stress and stroke, the method including obtaining a biological sample from an individual; measuring the levels of a set of biomarkers in the biological sample obtained from the individual; measuring the levels of a set of clinical markers of the individual; using a computer to programmatically generate an index based on the levels of biomarker in the biological sample obtained from the individual in combination with levels of the individual's clinical marker; and using the index to identify a likelihood that the individual will experience chronic stress and stroke.
Resumen de: WO2026064655A1
Provided are nucleic acids encoding voltage indicator polypeptides. In some instances, the voltage indicator polypeptide comprises a voltage-sensing domain (VSD) comprising four transmembrane segments, and a circularly permuted fluorescent protein inserted into an extracellular loop between the third transmembrane segment (S3) and the fourth transmembrane segment (S4) of the VSD. The voltage indicator polypeptide may comprise one or more amino acid substitutions and/or deletions, non-limiting examples of which include one or more substitutions at I412, F413 and/or Q414, wherein numbering of positions is according to SEQ ID NO: 1. Cells comprising the nucleic acids are also provided. In some embodiments, the cells are neurons that express the voltage indicator polypeptide on the plasma membrane of the neuron in a pan-membrane or targeted manner. Methods of recording the electrical activity of neurons are also provided, as are methods of assessing an effect of an agent on the electrical activity of neurons.
Resumen de: CN121152975A
The present invention relates to the use of biomarkers for measuring the efficacy or effectiveness of a treatment for neurodegenerative diseases, in particular Alzheimer's disease.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: WO2024243435A2
The present invention relates to compositions and methods for promoting the removal of misfolded proteins and protein aggregates. The compositions and methods may be used to treat or prevent a neurodegenerative disease or disorder associated with misfolded proteins or protein aggregates. In various embodiments, the compositions and methods relate to activators of one or more TRIM proteins.
Resumen de: AU2023447004A1
The present invention relates to methods for identifying the splicing of RAGE pre-mRNA resulting in the inclusion of exon 9b and/or exclusion of exon 10 in a subject in a subject who has received, or is receiving an antisense oligonucleotide that modulates RAGE pre-mRNA splicing. In one aspect, the present invention provides a method for determining endogenous soluble receptor for advanced glycation end products (RAGE) level in the lung of a subject, the method comprising: determining the presence of endogenous soluble RAGE in a blood sample from a subject who has received or is receiving a treatment administered to their respiratory tract, wherein the treatment increases endogenous soluble RAGE, wherein the level of endogenous soluble RAGE in the blood sample correlates with the endogenous soluble RAGE level in the lung of the subject.
Resumen de: CN121717902A
本公开提供了一种抗人磷酸化tau217的兔源单克隆抗体及其制备方法和应用，属于生物检测、生物工程技术领域。抗人磷酸化tau217的兔源单克隆抗体包括轻链可变区和重链可变区，单克隆抗体包括HZK33‑B0010、HZK33‑B0011和HZK33‑B0029。本公开开发了识别p‑tau217的三种兔单克隆抗体，其不会与非磷酸化的tau蛋白或其他位点的磷酸化tau蛋白发生交叉反应，能够高度特异性地结合p‑tau217，并以此开发出更具特异性的相关体液标记物检测试剂盒。
Resumen de: CN121721289A
本发明属于分子生物学领域，具体地，涉及一种空间蛋白质组学分析方法，更具体地，涉及一种同时进行细胞类型成像和原位蛋白质组学分析的空间蛋白质组学分析方法。使用本发明的方法能够在同一组织切片上同时进行细胞类型成像和原位蛋白质组学分析，减小潜在的偏差，使得分析结果更为准确。
Resumen de: CN121721265A
本公开涉及生物医学传感领域，具体涉及一种基于人工智能算法的单分子计数免疫分析系统，用于解决现有技术中在痕量蛋白检测和定量分析方面的灵敏度不足、信噪比不足、定量精度受限和数据处理效率低等问题。本公开技术方案通过明场和暗场双模式成像技术，针对基于利用离散载体及微纳荧光材料进行免疫分析的体系，结合图像处理算法和深度学习模型，提供高灵敏度、高精度、高信噪比的单分子免疫物质检测。
Resumen de: CN121717907A
本公开涉及生物医药领域，提供了一种人BCMA抗体及其应用。本公开提供的抗BCMA单克隆抗体1F5与BCMA抗原具有较强的亲和能力，Kd值为0.752×10‑9 M；为鼠源IgG1亚型，轻链为κ链；能够高亲和力结合BCMA阳性细胞系H 929和RPMI 8226，与多发性骨髓瘤病人来源的CD138阳性骨髓单个核细胞也能高亲和力结合。鉴于这些特性，单克隆抗体1F5既可用于检测表达人BCMA的细胞，也能够单独或与其它方法联合应用在靶向人BCMA的肿瘤免疫治疗中，具有诊断和治疗价值。
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: WO2024263939A1
The present disclosure relates method of identifying a compound targeting a first protein and a second protein, wherein the first protein and/or the second protein are associated with a disease or disorder.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: US20260079168A1
0000 The technology relates in part to antibodies or antigen-binding fragments thereof that bind Tau phosphorylated at threonine 217 (Tau phospho (Thr217)) or a portion thereof, as well as methods, systems and kits for detection of Tau phospho (Thr217). In certain aspects, the technology relates to antibodies or antigen binding fragments thereof for use in determining levels of Tau phospho (Thr217) in a sample containing or suspected of containing Tau phospho (Thr217). In some aspects, the technology relates to antibodies or antigen-binding fragments thereof for use in diagnosing or treating an individual with or suspected of having a disease or disorder associated with Tau phospho (Thr217).
Resumen de: AU2024319662A1
The disclosure features methods for treating neutralizing antibodies that reduce the efficacy of soluble alkaline phosphatase treatment (e.g., asfotase alfa), an enzyme replacement therapy, such as for the treatment of bone mineralization disorders, e.g., hypophosphatasia (HPP). The methods include diagnosing a subject as having the presence of neutralizing antibodies that affect the efficacy of treatment, administering a treatment suitable for reducing the deleterious effects of neutralizing antibodies, and continuing alkaline phosphatase treatment.
Nº publicación: WO2026060258A1 19/03/2026
Solicitante:
UAB RES FOUND [US]
Resumen de: WO2026060258A1
Disclosed herein is the use of gut microbiome (GM) as a therapeutic target for Parkinson's Disease (PD). Metagenomic biomarkers are identified that can stratify patients based on their dysbiotic features. Therefore, also disclosed is a companion diagnostic designed to identify patients that can be treated with an inhibitor of microbially induced amyloid.
BOPI
Sede Electrónica
