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一种用于齿科3D打印树脂的增韧增强惰性玻璃填料及其制备方法

Resumen de: CN123023987A

本发明公开了一种用于齿科3D打印树脂的增韧增强惰性玻璃填料，该玻璃填料按重量百分比包括SiO2 55‑68%，Al2O3 8‑15%，B2O3 5‑12%，BaO 8‑18%，ZrO2 2‑8%，Na2O 1‑4%，平均粒径为0.5‑3μm，表面经硅烷偶联剂处理。制备方法包括按配比称取原料混合后于1350‑1480℃熔融，水淬急冷，球磨粉碎，硅烷偶联剂表面改性。该填料具有良好的分散性和界面相容性，能够同时提高树脂的强度和韧性，添加该填料的齿科3D打印复合树脂抗弯强度可达115‑142MPa，断裂韧性1.6‑2.3MPa.√m，维氏硬度63‑75HV，制备工艺简单可控，适合工业化生产。

生物打印组织纤维的冷冻保存

Resumen de: WO2025099488A1

Aspects of the disclosure include cryopreserved tissue fibers and multilayer structures comprising said fibers, wherein the fibers encapsulate dissociated cells, and where the fibers and/or structured are cryopreserved prior to aggregation of the encapsulated cell population. Methods of making and using such fibers and structures are also provided.

一种多功能生物活性支架及其制造装置

Resumen de: CN123025376A

一种多功能生物活性支架制造装置，包括：支架打印模块，支架后处理模块，支架赋能模块，支架装配模块，控制模块和运输模块；所述控制模块控制支架打印模块，支架后处理模块，支架赋能模块，支架装配模块和运输模块的运作；支架打印模块为第一工序；支架后处理模块位于支架打印模块后面为第二工序；支架赋能模块位于支架后处理模块后面为第三工序；支架装配模块位于支架赋能模块后面为第四工序；所述运输模块与支架打印模块，支架后处理模块，支架赋能模块，支架装配模块相邻按工序顺序运输支架。本发明半自动化地实现了多功能生物活性支架按需个性化制造，可应用于大批量生产。

2D image arrangement

Resumen de: USRE51101E

Disclosed is a method of designing a dental restoration for a patient, wherein the method includes providing one or more 2D images, where at least one 2D image includes at least one facial feature; providing a 3D virtual model of at least part of the patient's oral cavity; arranging at least one of the one or more 2D images relative to the 3D virtual model in a virtual 3D space such that the 2D image and the 3D virtual model are aligned when viewed from a viewpoint, whereby the 3D virtual model and the 2D image are both visualized in the 3D space; and modeling a restoration on the 3D virtual model, where the restoration is designed to fit the facial feature of the at least one 2D image.

Tooth preparation guide device and method of preparing tooth for dental prosthesis

Resumen de: USRE51102E

Dental preparation uses a tooth preparation guide custom-made for fitting with teeth of a patient. The preparation guide includes one or more guide channels for guiding a cutting tool. The preparation guide enables modification of the teeth as planned with high level of precision. A dental prosthesis for installing onto prepared teeth of the patient is provided before preparation of the teeth. The prosthesis includes features that are complementary to the prepared teeth. The prosthesis can be installed immediately after preparing the teeth using the preparation guide. With the high level of accuracy and precision in the preparation of teeth, no modification of the prosthesis would be needed for installation.

一种中药热敷康复及被动拉伸3D打印外骨骼系统

Resumen de: CN122997902A

本发明公开了一种中药热敷康复及被动拉伸3D打印外骨骼系统，专门针对伴有感觉障碍的脑卒中或脊髓损伤瘫痪患者设计。系统采用热‑药‑力三维协同疗法：先由热敷打开毛孔、促进药物渗透，再由被动拉伸软化痉挛肌肉的先后协同治疗逻辑，3D打印机械腰部根据用户腰围尺寸个性化打印达到完全匹配，整体实现中药热敷‑机械拉伸的协同治疗。

基于三维打印技术的儿童开胸术后鸡胸矫正装置

Resumen de: CN224911316U

本实用新型公开了一种基于三维打印技术的儿童开胸术后鸡胸矫正装置，涉及医疗器械技术领域，包括矫正支架，矫正支架用于放置于胸骨与心包之间；矫正支架为由高分子材料制成的条形板状结构；矫正支架上设置有两列固定孔，两列固定孔分别位于矫正支架的左右两侧，且每列的固定孔均设置有多个，每个固定孔均由前至后贯穿矫正支架；同一行的两个固定孔之间能够穿设有胸骨线，以使矫正支架绑缚于胸骨上。本实用新型能够避免胸骨后壁与纵膈心包接触，并且，防止儿童胸骨生长发育畸形。

一种抗氧化可降解3D打印支架及其制备方法

Resumen de: CN122998459A

本发明公开了一种抗氧化可降解3D打印支架及其制备方法，属于骨缺损修复技术领域。本发明提供了一种PLGA/HA/MnO2三元复合3D打印生物墨水，通过MnO2纳米颗粒的引入赋予墨水优异的可打印性、力学支撑性、生物活性及免疫调节功能。在修复体结构方面，本发明涉及一种具有外壳‑网格复合结构的可降解缺损骨修复体，其外表面为致密的实心外壳（厚度0.2‑0.5mm），用于提供早期力学支撑并阻挡软组织长入，内部为网格结构（孔隙单元面积4‑6mm²，孔隙率45‑55%），用于引导新生骨长入和骨整合。本发明通过材料与结构的协同设计，实现了缺损骨修复的早期力学稳定、中期骨再生和远期功能重建，适用于颅骨、下颌骨、四肢长骨等多种缺损骨类型，具有良好的临床应用前景。

用于电刺激的电极结构

Resumen de: WO2025206723A1

An electrode structure for electrical stimulation according to an embodiment comprises: an electrode wire; and an electrode unit disposed on the outer surface of the electrode wire and including a plurality of electrode lines spaced apart from each other, wherein each of the plurality of electrode lines of the electrode unit is disposed in direct contact with the outer surface of the electrode wire.

用于在牙科修复体上印刷的陶瓷喷墨油墨组合物

Resumen de: US20250241734A1

Disclosed are systems and methods of a decision intelligence (DI)-based computerized framework that automatically and/or dynamically implements a color algorithm for performing staining and glazing dental restorations. The framework operates by leveraging determined color variations through AI/ML-based analysis that generate detailed color maps, which can be translated into precise printing instructions controlling the mixture and layering of dental-grade glazing materials. A printing system can employ multiple print heads with varying base colors and opacity levels to create microscopic color gradients and translucency effects matching natural tooth enamel. The disclosed automated processing applies personalized color patterns in microscopically thin layers, ensuring consistent glaze thickness while replicating regional variations across the tooth surface. Such approach eliminates manual glazing variability while achieving superior customization compared to traditional pre-set patterns, resulting in dental restorations that integrate seamlessly with existing teeth.

用于打印高密度组织纤维的系统和方法

Resumen de: WO2025099487A1

Aspects of the disclosure include microfluidic print heads for bioprinting core/shell fibers having consistent diameters and shell thicknesses, and methods of making high-density tissue fibers comprising cell populations of therapeutic interest for implantation, as well as the high-density tissue fibers produced thereby.

ポリオキサゾリドン誘導体及び医療デバイスにおけるそれらの使用

Resumen de: EP4541837A1

0001 The invention provides poly(hydroxy oxazolidone) compounds (PHOx) corresponding to following formula (I) or formula (II): wherein R<1'>, R<2'>, independently of one another each denote a C1 to C20 alkyl group, preferably a C1 to C10 alkyl group, more preferably a C1 to C3 alkyl group, most preferably a methyl group, and - R<3>, R<4> independently of one another each denote hydrogen or a C1 to C20 alkyl group, preferably a C1 to C10 alkyl group, more preferably a C1 to C3 alkyl group, most preferably a methyl group, and - R<5>, R<5'>, R<6>, R<6'>, independently of one another each denote hydrogen or a C1 to C20 alkyl group, preferably a C1 to C10 alkyl group, more preferably a C1 to C3 alkyl group, most preferably a methyl group, or an aryl group, preferably a phenyl group, and - A is an organic linking group selected from a linear, branched, saturated, unsaturated, cyclic and/or non-cyclic aliphatic, aromatic or araliphatic hydrocarbon group, preferably having 1 to 20, more preferably 1 to 12, most preferably 1 to 8 carbon atoms and optionally further containing one or more functional groups selected from ether, ester, amide, amine, carboxyl, sulfur, halogen and/or urethane, and - Optionally A, R<3> and R<4> in formula (I) are linked to each other to form a cyclic structure, and - Optionally R<5> and R<5'>, and/or R<6> and R<6'> in formula (II) are respectively linked to each other to form a cyclic

ANTI-CLOGGING AND ANTI-ADHESIVE MICRO-CAPILLARY NEEDLE WITH ENHANCED TIP VISIBILITY

Resumen de: WO2020006413A1

An object of the present invention is to provide an anti-adhesive/anti-clogging and/or color marked/tinted micro-capillary tube (microtube), microneedle, or micropipette. Typically, the color/tint will be selected such that the tip of the microneedle or micropipette is in contrast (e.g., visually) to the biological material. The tint/color may be selected to contrast the stained biological material. In some aspects, the color mark comprises nanoparticles that are modified by adding a non-adhesive coating/material that minimizes protein adhesion/adsorption. The microtubes and/or micropipettes may be treated with an anti-clogging reagent and an anti-adhesive reagent to prevent or reduce clogging and adhesion of the micropipette or microneedle to biological materials. The microtubes and/or micropipettes may be formed using additive printing processes and additive manufacturing techniques or from micropipette and microneedle pullers.

壳状牙齿矫治器的生产方法及生产系统

Resumen de: CN123001256A

本发明公开一种壳状牙齿矫治器的生产方法，用于采用热压膜工艺制造壳状牙齿矫治器，在脱膜形成壳状牙齿矫治器前，以同一病例信息完成初步分选，形成牙颌模型流转单元或压膜组件流转单元进行流转，具体地，可以在牙颌模型打印工序之后即识别牙颌模型的第一标识信息，并根据同一病例信息对牙颌模型进行分选，也可以在压膜工序之后即识别压膜组件中牙颌模型上的第一标识信息，并根据同一病例信息对压膜组件进行分选，从而在矫治器脱膜工序之后，获得同一病例的壳状牙齿矫治器形成的矫治器流转单元，在矫治器分拣工序只需识别壳状牙齿矫治器的第二识别信息进行分拣，并经矫治器包装工序完成包装。本发明还相应地提供一种壳状牙齿矫治器生产系统。

一种基于医学影像处理与3D打印的快速骨修复体制造方法

Resumen de: CN123001221A

本申请涉及医疗技术领域。通过提供一种基于医学影像处理与3D打印的快速骨修复体制造方法，该方法包括：在修复体外轮廓约束模型内部生成孔隙率和力学性能呈连续梯度变化的多孔支架数字模型；选用由生物相容性聚合物和生物活性陶瓷复合而成的成型丝材，针对多孔支架数字模型规划沿曲面连续无间断的挤出路径，通过熔融沉积成型工艺将成型丝材打印为物理修复体，对物理修复体依次进行表面活化改性和基于无损扫描的制造偏差检测，获得成品骨修复体，以达到提升骨组织分割自动化水平和缺损边界提取精度、实现修复体力学性能与骨组织生长需求的梯度适配、降低植入物内部孔隙结构相对于设计模型失真程度的技术效果。

一种荷叶炭碳量子点、制备方法及其在制备治疗肥胖药物中的应用

Resumen de: CN122998230A

本发明公开一种荷叶炭碳量子点、制备方法及其在制备治疗肥胖药物中的应用，所述荷叶炭碳量子点以荷叶为碳源制备得到，为纳米级颗粒，颗粒表面含有羟基和羧基；所述荷叶炭碳量子点的制备方法，包括步骤：（1）将干燥荷叶粉碎、过筛，获得荷叶粉末；（2）将荷叶粉末置于保护气氛下，碳化处理，得到碳化产物；（3）将碳化产物研磨后分散于溶剂中，经固液分离、纯化、干燥处理，制得所述荷叶炭碳量子点。该碳量子点兼具良好的水溶性及抗肥胖活性，解决了传统荷叶炭或荷叶提取物直接给药生物利用度低、体内作用时间短的问题。

Verfahren zur Herstellung eines kieferorthopädischen Artikels

Resumen de: CH722745B1

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung eines kieferorthopädischen Artikels umfassend eine auf einen Patienten individualisiert angepasste Komponente aus Titan oder einer Titanlegierung, insbesondere einer Zahnspange. Das Verfahren weist die Schritte auf, dass a.) ein dreidimensionales Bild mindestens eines Teils des Mundraums des Patienten erstellt wird, b.) auf Basis des in a.) erstellten Bildes ein virtuelles 3D-Modell des kieferorthopädischen Artikels erzeugt wird, c.) auf Grundlage der Daten des virtuellen Modells ein Rohling des kieferorthopädischen Artikels mittels 3D-Metalldruck aus einem Titan bzw. die Titanlegierung enthaltenden Pulver hergestellt wird, und d.) auf der Oberfläche des in Schritt c.) hergestellten Rohlings eine im Wesentlichen homogene und porenfreie Titanoxidschicht mit einer Dicke von mehr als 10 nm durch elektrochemische Anodisierung gebildet wird.

一种多材料、多细胞体积生物打印方法

Nº publicación: CN122998472A 30/10/2026

Solicitante:

广州医科大学

Resumen de: CN122998472A

本发明公开了一种多材料、多细胞体积生物打印方法，包括提供至少两种具有双水相分离特性的光交联水凝胶溶液，分别负载不同细胞后依次注入打印容器，静置使其自发形成具有清晰相界面的空间分区结构；再采用体积生物打印技术，以单次光辐射模式进行同步光交联固化，且根据不同材料的光衰减特性分别设定各分区的光衰减补偿系数，确保各层实际接收光照剂量均达完全交联阈值。本发明将水相分离机制与体积打印一体化成型技术深度融合，突破传统体积打印仅能构建单一材料结构的局限，可实现多材料、多细胞在三维空间中的精准分区排布，同时保证层间界面清晰稳定，细胞存活率高，成型速度快，为构建三维组织模型提供可靠的技术支持。