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MEW TISSUE SCAFFOLD

Resumen de: AU2023365980A1

A melt electrowritten soft tissue scaffold, comprising: a first region having one or more sets of fibres and a second region having one or more sets of fibres; and an interface region joining the first region and the second region, the interface region being electrowritten along with the first and second regions in a continuous printing path, such that fibres in the interface region each join between a respective pair of fibres in the first and second regions.

DEVICES WITH LUMINA FOR BONE IMPLANTATION

Resumen de: AU2023371660A1

Provided herein are medical devices and methods for treating bone fractures. The medical device comprises a body with a proximal end and a distal tip, housing a scaffold with a porous structure distributed in proximal and distal lattices. The device includes an upper lumen in fluid communication with a first opening at the proximal end, and a lower lumen in fluid communication with a second opening at the proximal end. The device is configured to support independent delivery of cement and cells to the lattices. In some embodiments, the device is a bone screw with a thickened head-neck junction, designed to reduce the likelihood of rod breakage during installation. The methods involve implanting the device into a patient's bone, providing an innovative approach to fracture treatment.

BIOPRINTED SOFT TISSUE REINFORCEMENT SCAFFOLD

Resumen de: AU2023346376A1

The disclosure encompasses systems, compositions, and methods for use in vivo, including for reinforcement of soft tissue in an individual. The systems, compositions, and methods may utilize three-dimensionally printed scaffolds comprising at least a polymer scaffold and an extracellular matrix component(s), including comprised on the scaffold. The polymer scaffold may comprise particular unit cell structures of a specific design and patterns of alternating configurations of the unit cell structures.

POLYMERIC STRUCTURES HAVING A MICRO-VOID SPACE AND SYSTEMS AND METHODS FOR MAKING SAME

Resumen de: AU2023364836A1

Aspects of the present disclosure include methods for making a polymeric structure having a micro-void space. Methods according to certain embodiments include irradiating a polymerizable composition positioned between a build elevator and a build surface to generate a polymerizable composition having a polymerized region of the polymerizable composition having a micro-void space in contact with the build elevator and a non-polymerized region of the polymerizable composition in contact with the build surface, displacing the build elevator away from the build surface, contacting the generated micro-void space with a non-reactive composition and repeating in a manner sufficient to generate a polymeric structure having a resolved micro-void space. Systems for preparing a polymeric structure according to the subject methods are also described. Polymeric structures having a resolved micro-void space such as where the micro-void space is filled with a non-polymerizable composition are also provided.

BONE HARVESTING DEVICES FOR BONE IMPLANTATION

Resumen de: AU2023371661A1

Provided herein are medical devices and methods for treating bone fractures. The medical device comprises a body, a scaffold within the body, and a means for focusing bone growth throughout the body. The device is designed to minimize shear stresses on a distal tip and distribute micromotion to encourage bony ingrowth. The scaffold may include a triply periodic minimal surface (TPMS) with a cubic repeating pattern defining walls within the scaffold, and the TPMS may be helically wrapped around a central axis of the device. The device may also house biologic agents and accommodate an autologous product. In some embodiments, the medical device is a bone screw or a pedicle screw, designed to reduce common issues such as screw loosening, screw backout, and rod breakage. The method of treatment involves implanting the medical device into a patient's bone to aid fracture healing.

一种3D打印个体化HTO术中快拆撑开器

Resumen de: CN119896501A

本发明涉及一种3D打印个体化HTO术中快拆撑开器，属于HTO截骨技术领域，包括多个采取锁扣结构进行组合形成楔形垫块的分块和用于对多个分块进行锁定的锁销。本发明通过多个分块的组合结构使垫块是可拆分的，便于手术完成后轻松取出，并不需要破坏才能取出，从而避免内部未消毒碎片的污染风险，并通过锁扣结构进行组合、锁销进行锁定，形成整体的楔形垫块，从而保证下肢力线的准确矫正，安全性和便携性得到显著提升。

METHOD FOR PRODUCING A DENTAL RESTORATION

Resumen de: KR20220049473A

The present invention relates to a method for designing dental restorations. The method comprises: determining a target data set on the basis of natural teeth to reflect at least one of optical characteristics and geometry of the natural teeth (S101); creating a digital teeth model having an internal architecture (S102); rendering the digital teeth model on the basis of the internal architecture to create an actual data set reflecting at least one of the optical characteristics and geometry of the digital teeth model (S103); calculating a deviation between the target data set and the actual data set (S104); and iteratively changing the digital teeth model to obtain a small deviation between the detected target data set and an actual data set of a re-rendered digital tooth model (S105).

一种透明3D打印手术导向器及材料

Resumen de: CN119896547A

本发明涉及外科器械材料领域，更具体的是涉及一种透明3D打印手术导向器及材料。导向器包括基体，基体由透明3D打印材料制成，用于附着在目标骨骼的外表面；基体包含多个解剖附着部，每个解剖附着部的附着面分别对应不同解剖部位；多个传感器，用于实时监测解剖附着部与目标骨骼的贴合情况；信号转换模块，嵌入在基体内部，用于将传感器的信号转换为可视信号；多个微型灯泡，微型灯泡镶嵌在基体内部，微型灯泡与信号转换模块连接，微型灯泡的亮度根据传感器的信号变化而变化；电源模块，用于为传感器、信号转换模块和微型灯泡提供电力。本发明提供了一种兼具全域可视化、解剖普适性和实时力反馈的新型手术导向器。

A BIO-INK FOR 3D PRINTING, RELATED CONJUGATE AND PREPARATION PROCESS OF AN INTERMEDIATE CONSISTING OF A PHOTOREACTIVE LINKER

Resumen de: US2024217166A1

A bio-ink for use in 3D printing, the related conjugate and the preparation process of an intermediate consisting of a bifunctional photoreactive linker are described. Said bio-inks are used for the manufacturing of constructs by 3D printing.

METHODS AND SYSTEMS FOR GENERATING THREE-DIMENSIONAL BIOLOGICAL STRUCTURES

Resumen de: US2022389373A1

One aspect of the invention provides a method of generating three-dimensional biological structures. The method includes: (a) depositing a first layer of a suspension over a substrate, the suspension including a liquid and a plurality of cells; (b) allowing the plurality of cells to attach to the substrate and form a first layer of attached cells; (c) depositing a cell-attachment agent over the first layer of attached cells; and (d) depositing a second layer of the suspension over the cell-attachment agent.

一种具有多层次孔结构的聚己内酯支架及其制备方法和应用

Resumen de: CN119868647A

本发明属于医用支架技术领域，特别涉及一种具有多层次孔结构的聚己内酯支架及其制备方法和应用。本发明聚己内酯支架包括聚己内酯支架本体，以及附着在聚己内酯支架本体表面的ZIF8；聚己内酯支架本体的基体材料为聚己内酯，聚己内酯的纤维之间及纤维表面均具有微米孔结构，纤维之间的微米孔结构的尺寸大于纤维表面的微米孔结构的尺寸。本发明聚己内酯支架本体具有宏观大孔及微观小孔，可提高支架本体的比表面积，表面粗糙度，进而提高聚己内酯支架本体的降解效果，还可促进细胞粘附；此外，大比表面积可为ZIF8沉积提供更多的位点，利于提升聚己内酯支架的生物活性，适于骨缺损的再生修复，且具有良好的机械强度、生物相容性、抗菌性。

一种基于3D打印的个性化跗跖关节固定板

Resumen de: CN119867900A

本发明公开了一种基于3D打印的个性化跗跖关节固定板，其中，包括：第一贴合板、第二贴合板和第三贴合板首尾依次连接组成三角形结构；第一贴合板和第三贴合板的连接处向外凸出设有第一固定部；第一贴合板和第二贴合板的连接处向外凸出设有第二固定部；第二贴合板和第三贴合板的连接处向外凸出设有第三固定部；第一贴合板和第三贴合板整体呈弧形设置，第二贴合板呈直线形设置。本申请采用第一贴合板、第二贴合板、第三贴合板、第一固定部、第二固定部和第三固定部一体成型，实现固定板对内侧楔骨、中间楔骨以及第二跖骨的固定与支撑，实现对近跗跖关节损伤的治疗，既避免了空心螺钉植入难度过高的问题，还能缩短手术时间，降低手术风险和成本。

用于可缝合柔性材料的互穿聚合物网络

Resumen de: AU2023315783A1

An advanced manufactured interpenetrating polymer network (AM-IPN) comprising: a primary polymer network; a secondary polymer network, wherein the secondary polymer network is bonded to the primary polymer network via one or more crosslinks, wherein one or more of the primary polymer network, the secondary polymer network and the one or more crosslinks are printed using a synthetic bioink is disclosed. Methods of making and using are also disclosed.

Procédé d’irradiation sélective contrôlée en temps réel d’une dose prédéterminée sur une zone cible d’une surface, et système correspondant

Resumen de: FR3154339A1

La présente invention a pour objet un procédé d’irradiation sélective contrôlée d’une zone cible d’une surface d’un produit ou d’un être vivant donné, pour permettre la radiation locale de cette zone cible en vue d’obtenir un effet cible, ce procédé étant mis en œuvre par un système comprenant un dispositif émetteur, au moins un dispositif de mesure et d’analyse et un dispositif contrôleur, ce procédé comprenant des étapes de :-mesure et enregistrement en temps réel de l’énergie principale réelle au niveau de la zone cible,-analyse et enregistrement de l’effet réel obtenu au niveau de cette zone cible, et-contrôle en temps réel du dispositif émetteur par le dispositif contrôleur, en prenant en compte la mesure de l’énergie principale réelle et l’analyse de l’effet réel, lesquelles sont comparées respectivement à un seuil énergétique prédéterminé associé à la zone cible et à l’effet cible attendu, de manière à ce que, si le seuil énergétique prédéterminé n’est pas atteint mais l’effet cible est obtenu, l’irradiation de la zone cible est stoppée. Figure pour l'abrégé : 1

生物玻璃纤维对增材制造聚合物的增强

Resumen de: US2024016578A1

Disclosed herein are methods for manufacturing medical devices, such as implants, joint replacements, graft materials, augmentation materials, prosthetic materials, etc., from solid material reinforced curable resins. Methods of repositioning a patient's teeth using such medical devices are also provided.

全数字化活动支架义齿装置及其制作方法

Resumen de: CN119867979A

本发明公开了一种全数字化活动支架义齿装置及其制作方法，其包括金属支架，还包括基托和固定在基托上的义齿，所述金属支架上设置有定位凸起，所述基托上设置有与定位凸起配合的定位凹槽，所述金属支架和基托通过粘接方式连接成一体。本发明取消了传统活动支架义齿装置制作工艺中的基托的注塑成型工艺流程，基托和金属支架之间通过定位凸起和定位凹槽相配合来确定组合位置，并通过粘接方式固定成一体，使得活动支架义齿装置的制作时间大大缩短，生产效率能得到很大提升。

一种白磷钙石-聚乙二醇-聚乳酸形状记忆聚合物及其制备方法以及在制备骨修复支架中的应用

Resumen de: CN119875333A

本发明提供了一种白磷钙石‑聚乙二醇‑聚乳酸形状记忆聚合物及其制备方法以及在制备骨修复支架中的应用，属于生物医用材料技术领域。本发明采用聚乙二醇和白磷钙石分别作为构建电生理微环境促进成骨和调节聚合物变形温度的改性材料，与聚乳酸基体进行物理共混，制备出3D打印形状记忆聚乳酸基复合材料。根据人体股骨受力情况，设计应力诱导结构骨支架，符合人体股骨生物力线分布和交错结构特征。本发明通过3D打印技术制备应力诱导结构骨修复支架，其性能兼具玻璃化转变温度较低、电活性较好、形状记忆功能强、生物相容性与可降解性较好，为骨修复支架提供了一种新选择。

一种可定制的微丝电极阵列及其制备方法

Resumen de: CN119867768A

本发明公开了一种可定制的微丝电极阵列及其制备方法，该可定制的微丝电极阵列包括可定制基底，所述可定制基底内部设有根据脑区定制化分布的穿孔槽；微丝电极阵列，所述微丝电极阵列从上向下穿过所述穿孔槽；封装材料，所述封装材料位于可定制基底底部，用于固定微丝电极阵列。该微丝电极阵列具有较好的灵活性，加工较为简单。

患者接口及其衬垫

Resumen de: WO2024011290A1

A patient interface comprising a plenum chamber, a seal-forming structure constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways, and a vent to allow a continuous flow of gases exhaled by the patient from an interior of the plenum chamber to ambient. The seal-forming structure may comprise a cushion, the cushion being deformable and resilient and at least partially formed by a lattice structure.

一种可定制核素水凝胶敷贴器的制备方法

Resumen de: CN119868827A

本发明公开了一种可定制核素水凝胶敷贴器的制备方法，包括：采集病灶部位的图像；根据图像进行对病灶进行三维建模；对病灶的三维模型进行切片，并利用3D打印机打印出与病灶部位形状适配的模具；将核素溶液和水凝胶前驱体溶液加入模具，经光照固化，取出水凝胶敷贴器并封装于两层透明胶带间。本申请可针对不同形状病灶定制与病灶部位适配的核素水凝胶敷贴器，有助于提高治疗效果。而且与目前临床主要依靠医护人员描摹病灶形状来制备敷贴器的繁琐过程相比，本申请制备方法更安全、更高效且形状适配度更高。

人工血管ネットワークの連続線維支持バリア

Resumen de: CN119013055A

Disclosed herein are devices comprising one or more channels defining a lumenal space, wherein the lumenal space is defined by an inner wall of a fibrous basement membrane material; and methods of making and using the same.

SONO-INK FOR VOLUMETRIC PRINTING

Resumen de: WO2025085893A1

A sono-ink composition is described that includes a acrylate oligomer, an acoustic absorber, and a thermal initiator. A method of using the sono-ink for deep-penetrating volumetric printing is also described. The method includes the steps of a) providing a volume of a sono-ink composition, comprising a acrylate oligomer, an acoustic absorber, and a thermal initiator; b) directing a focused acoustic projection of ultrasound waves into the volume of the sono-ink, wherein the focused acoustic projection of ultrasound waves has an intensity and frequency sufficient to activate the thermal initiator so that local polymerization is achieved at a desired region within the volume of sono-ink; and c) optionally repeating step b wherein the focused acoustic projection of ultrasound waves is directed to selected regions within the sono-ink, until a three-dimensional object is formed.

SYSTEM AND METHOD FOR ADDITIVE MANUFACTURING USING PROCESS ANALYTICAL TECHNOLOGY

Resumen de: WO2025085778A1

A binder jet printing system that uses one or more process analytical techniques in the processing of articles. The system has one or more fabrication substrate with one or more formation surfaces, an article forming system having a depositing device for placing a construction material onto the one or more formation surfaces when the fabrication substrate is positioned at a deposition position, and a processing device for performing a process unit operation on the construction material when the fabrication substrate is disposed at a processing position; a movement controller to control transporting of the one or more fabrication substrates between the deposition position and the processing position for forming the article; and one or more process analytical technologies for monitoring, scanning or detecting one or more physical or chemical properties of an article, an intermediate product, or an ingredient used in the manufacturing of the articles.

RESIN COMPOSITION FOR STEREOLITHOGRAPHY

Resumen de: WO2025084430A1

The present invention provides a resin composition for stereolithography, the composition producing a formed object having excellent strength, toughness, water resistance, and stress retention while exhibiting little elution. The present invention relates to a resin composition for stereolithography, the composition containing: (A) a monofunctional methacrylic polymerizable compound having independent multiple aromatic rings; (B) a multifunctional (meth)acrylic polymerizable compound; and (C) a polymerization initiator.

AN ANTIVIRAL PHOTOSENSITIVE COMPOSITION AND DEVICE FOR POTENTIATING THE SAME

Nº publicación: WO2025083710A1 24/04/2025

Solicitante:

FOCELITE GOODNESS INDIA PRIVATE LTD [IN]
FOCELITE GOODNESS INDIA PRIVATE LIMITED

Resumen de: WO2025083710A1

An antiviral photosensitive composition and device for potentiating the same Embodiments herein disclose a device 100 for potentiating at least one phenothiazinium compound and method for operating the same. The device 100 is placed on a hand of the subject, such that the plurality of LEDs (205) are in proximity to the venous side of the hand of the subject. Embodiments herein further disclose an antiviral photosensitive composition including at least one phenothiazinium compound; at least one pharmaceutically acceptable carrier; and water. The antiviral photosensitive composition combined with the device 100, is effective against dengue virus and serotypes thereof.