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重组蛋白、重组DNA序列、载体、真核和原核表达系统及其用途

Resumen de: WO2025014382A1

The invention relates to recombinant RE15mR and EJ17zipR hybrid proteins with the structure specified in the description, recombinant DNA sequences encoding recombinant hybrid proteins, vectors containing recombinant DNA sequences, as well as eukaryotic or prokaryotic expression systems transformed with recombinant DNA sequences. The invention also concerns the use of recombinant hybrid proteins as components of bioink intended for bioprinting, and also as components of biomaterials. Furthermore, the invention relates to the use of recombinant DNA sequences, vectors and eukaryotic or prokaryotic expression systems for the production of recombinant hybrid proteins.

一种复合驻极体柔性生物静电驻极体贴片及其制备方法

Resumen de: CN121971609A

本发明涉及医用生物材料技术领域，具体公开了一种复合驻极体柔性生物静电驻极体贴片及其制备方法，所述静电驻极体贴片，包括由外至内依次设置的背衬层、医用压敏胶层和功能层。本发明功能层选用聚乳酸、聚偏氟乙烯、聚乳酸‑羟基乙酸共聚物中的至少一种作为聚合物基体，与石墨烯进行复合，并采用超声分散与高精度3D打印结合的特定工艺，引入了深能级电荷陷阱，解决了高导电填料团聚与表面电荷泄漏的难题，使得材料900天后表面电位保持率可达60%以上，空气暴露8小时电荷流失率不大于20%，实现了无药物、无透皮条件下的高效物理静电驻极辅助睡眠治疗。

通过对移动设定的牙齿模型进行校正的正畸装置设计方法

Resumen de: WO2025079952A1

The present invention is a method for designing an orthodontic device by using a computer, comprising the steps of: (S01) displaying a teeth arrangement image; (S02) correcting an arrangement state of teeth in the teeth arrangement image; (S03) correcting the shape of teeth in the teeth arrangement image; (S04) displaying the orthodontic device on a screen according to the corrected teeth arrangement image; and (S05) outputting the orthodontic device by using a 3D printer.

pH响应型MOF材料、包含其的复合光敏树脂体系及在齿科矫治器中的应用

Resumen de: CN121975065A

本发明提出了pH响应型MOF材料、包含其的复合光敏树脂体系及在齿科矫治器中的应用；所述pH响应型MOF材料为“核‑壳‑卫星”结构多功能金属有机框架材料（Guardian‑MOF），该MOF被化学键合到光固化树脂基质中，形成一种可3D/4D打印的智能复合树脂，制成的矫治器在宏观上具备所需的力学性能以完成正畸功能，在微观上则是一个分布式、智能化的“微诊所”，能够精准响应口腔致病微环境（低pH），并协同执行多重抗菌与靶向再矿化治疗，具备显著的应用前景。

一种纤维增强3D打印生物墨水及其制备方法

Resumen de: CN121971703A

本申请涉及一种纤维增强3D打印生物墨水及其制备方法，包括以下质量份的原料：明胶1.0‑20.0份，海藻酸钠0.1‑10.0份，预处理细菌纤维素分散液0.01‑10份，水60‑100份，所述预处理细菌纤维素分散液包括以下制备步骤：将细菌纤维素凝胶加水打碎，用胶体磨循环2‑4次，转速5000‑15000rpm，间隙30‑100μm，真空脱泡10‑20min得到预处理细菌纤维素分散液。

基于3D打印的仿生椎间盘一体化类器官及其构建方法与应用

Resumen de: CN121950678A

本发明公开了基于3D打印的仿生椎间盘一体化类器官及其构建方法与应用，涉及生物医学工程领域。该构建方法包括以下步骤：采用聚合物材料通过3D打印制备交叉网状仿生支架，经卷曲成型为圆柱状纤维环结构，得到纤维环仿生支架；将多能干细胞经中胚层诱导后，分别进行软骨诱导和纤维软骨诱导，获得类髓核的软骨类器官与类纤维环的纤维软骨类器官；将该软骨类器官置于该纤维环仿生支架的中心，该纤维软骨类器官填充于该纤维环仿生支架的网格结构中，经基质胶包裹和孵育固化后，经诱导培养得到该基于3D打印的仿生椎间盘一体化类器官。本发明提供的基于3D打印的仿生椎间盘一体化类器官，能够有效复现天然椎间盘的结构特征与功能特性。

具有改进的SLS 3D打印烧结性能的聚己内酯

Resumen de: WO2025073518A1

The present invention refers to a compound particle for 3D printing obtained by hot melt extruding 50 to 90 wt.-% at least one polycaprolactone based polymer; 10 to 50 wt.-% of at least one filler; and optionally up to 5 wt.-% of at least one additive into pellets, wherein the total weight of the components is 100 wt.-%, and thereafter milling the pellets to obtain the compound particle. Furthermore, the present invention refers to a composition for 3D printing comprising a) 94 to 99 wt.-% of at least one compound particle according to the present invention; b) 1 to 6 wt.-% of at least one filler; and c) optionally up to 5 wt.-% of at least one additive; wherein the total weight of a) to c) is 100 wt.-%. Moreover, the present invention refers to a 3D printing method comprising the compound particle or the composition according to the present invention, the article obtained by the 3D printing method and its use as a substitute for bones or a scaffold for broken bones.

一种下颌髁突固定板组件及制作方法

Resumen de: CN121943445A

本发明公开了一种下颌髁突固定板组件及制作方法，下颌髁突固定板组件设置在骨折块和下颌骨本体上，下颌髁突固定板组件包括：第一固定板，分别连接骨折块和下颌骨本体；第二固定板，分别连接骨折块和下颌骨本体；第一固定板和第二固定板活动连接；第一固定板上设置有第一防滑部，第二固定板上设置有第二防滑部。本发明的有益效果是：通过第一固定板和第二固定板的活动连接，以将骨折块的空间位置进行精确定位及固定，替代“徒手复位” 的经验依赖，实现术中 “连接即复位” 的精准操作，降低术后咬合紊乱、颞下颌关节功能障碍等并发症的发生率。在第一固定板和第二固定板分别设置第一防滑部和第二防滑部，以增加骨‑板摩擦力，从而防止骨折块移位。

エアアシスト型付勢部を備えた織物シール

Resumen de: WO2020165761A1

A patient interface comprises a plenum chamber and a seal-forming structure. The seal-forming structure comprises a support structure arranged to support a sealing portion that is adapted to sealing engage the patient's face in use. The seal-forming structure may also include a seal biasing portion configured to inflate under pressurization within the cavity in the cushion assembly in use to extend the reach of the sealing portion and decouple the sealing portion from external forces.

一种具有递进式变化孔隙率的三层人工软组织修复膜

Resumen de: CN121943521A

本发明公开了生物医学组织工程领域的一种具有递进式变化孔隙率的三层人工软组织修复膜，该修复膜由内向外依次包括有序纤维层、螺旋无序纤维层和有序纤维层，形成孔隙率递进增大的结构。各层采用生物可降解材料制成，可选自多种天然或合成聚合物。纤维直径在纳米级至微米级范围，有序纤维层的纤维间距可调且由内向外递增。该膜可负载多种生物活性物质与药物，其表面也可用生长因子或纳米材料等修饰。制备方法主要采用近场直写3D打印工艺，通过调控打印参数实现。所得修复膜孔隙结构独特，能模拟天然组织，促进细胞有序生长与组织修复，适用于组织工程支架领域。

一种可光固化Matrigel基质胶的生物墨水、制备方法及在体积生物打印中的应用

Resumen de: CN121944242A

本发明属于生物打印技术领域，具体公开了可光固化Matrigel基质胶的生物墨水、制备方法及在体积生物打印中的应用，该生物墨水由水凝胶和Matrigel基质胶混合后加入光引发剂制成，能在光源的照射下实现可控固化，解决了现有技术中Matrigel基质胶缺乏光敏基团导致无法进行光交联反应的问题，本发明还通过将该生物墨水与生物介质混合，得到了复合生物墨水并与GLVBP技术完美兼容，打印成型的结构具有高精度、高细胞活性及良好的生物相容性，在类器官培养、组织工程等生物医学领域具有广阔的应用前景。

一种负压产生装置

Resumen de: CN224180017U

本实用新型公开了一种负压产生装置，该装置包括本体和连接于本体的握持部，本体顶端设有开口，本体底端设有多个通孔，开口和通孔之间连接壁面，使壁面内由开口至通孔形成腔体；本体还设有：控制模块，控制模块设于壁面外；料仓，料仓为无顶盖的筒状结构；筒底部设有若干小孔；料仓上设有升降模块，所述升降模块连接驱动机构以使料仓在腔体内进行上升或下降；驱动机构连接控制模块；握持部两端开口，一端连通于本体的底端，另一端为负压作用口。本实用新型的负压产生装置结构简单，使用方便，该装置底部的负压作用口可精准适配身体各个部位，用于在身体部位产生负压。通过控制模块对升降模块的位移，使料仓靠近或远离负压作用口，实现负压作用口附近的自动控温。

一种3D打印用齿科TC4/TAl混合粉末及其制备方法

Resumen de: CN121943677A

本申请涉及齿科材料的技术领域，具体公开了一种3D打印用齿科TC4/TAl混合粉末及其制备方法。3D打印用齿科TC4/TAl混合粉末的化学成分如下，Al：2.75‑4.75wt.%，V：1.75‑3.25wt.%，Ti余量。其制备方法包括如下步骤：将TC4粉末和TAl粉末分别过筛，得到符合要求的备用TC4粉末和备用TAl粉末；在惰性气体保护下，按配比混合，真空干燥、过筛后，得到3D打印用齿科TC4/TAl混合粉末。本申请可以获得化学成分均匀、流动性好的粉末，而且成型样件的强度和韧性的平衡更优异，更适用于3D打印工艺制作齿科修复体。

Systems and Methods for Immobilizing Extracellular Matrix Material on Organ on Chip, Multilayer Microfluidics Microdevices, and Three-Dimensional Cell Culture Systems

Resumen de: US20260117154A1

0000 The presently disclosed subject matter provides an approach to address the needs for microscale control in shaping the spacial geometry and microarchitecture of 3D collagen hydrogels. For example, the disclosed subject matter provides for compositions, methods, and systems employing N-sulfosuccinimidyl-6-(4′-azido-2′-nitro-phenylamino)hexanoate (“sulfo-SANPAH”), to prevent detachment of the hydrogel from the anchoring substrate due to cell-mediated contraction.

服薬支援システム

Resumen de: WO2026084071A1

A medication support system provided with a medication support apparatus for performing a medicine dispensing operation in which a medicine package stored in a storage is transferred to a corresponding medicine storage part to dispense the medicine. The medication support system includes: a plurality of medication support apparatuses having mutually different configurations related to the medicine dispensing operation; and a management apparatus that is communicatively connected to the plurality of medication support apparatuses and manages control information for controlling each medicine dispensing operation of the plurality of medication support apparatuses.

ALERT MANAGEMENT IN FLUID DELIVERY SYSTEM

Resumen de: US20260120842A1

0000 A fluid delivery system displays, on a display screen, fluid identifiers including a first fluid identifier indicating a first fluid and a second fluid identifier specifying a second fluid. The fluid delivery system further displays, on the display screen, a first indication of receiving an excessive number of fluid delivery pump programming alerts associated with the first fluid identifier. The fluid delivery system adjusts a first fluid delivery limit setting associated with delivery of the first fluid in response to the excessive number of fluid delivery pump programming alerts associated with the first fluid identifier. The fluid delivery system implements the adjusted first fluid delivery limit setting for each of multiple fluid delivery pumps subsequently requesting to deliver the first fluid to a respective recipient.

MAXILLARY MODELLER

Resumen de: US20260114961A1

The invention relates to a maxillary modeller (2) intended to be worn, in a service position, on a dental arch of a user in order to modify the shape of the palate, the maxillary modeller being one-piece and removable and comprising: —a central palatal portion (22) configured to be in contact with the user's palate when the maxillary modeller is in the service position; and —a first and a second dental portion (24; 26) each comprising at least one, preferably multiple cavities configured to receive teeth of the user when the maxillary modeller is in the service position, the first and second dental portions extending on either side of the central palatal portion, the central palatal portion being configured so as to exert on the palate, in the service position, forces suitable for modifying the shape thereof.

SYSTEMS AND METHODS FOR DIGITALLY MODELING ARTICULATION

Resumen de: US20260114967A1

Systems for modeling a digital articulator may include a processor in electronic communication with an extraoral imaging device and an intraoral imaging device and a non-transitory computer readable medium having instructions stored thereon that when executed by the processor capture 3D data of the patient's face in with the extraoral imaging device, capture a 3D model of the patient's dentition, align the 3D model of the patient's dentition with 3D data of the patient's face, generate an estimate of the temporomandibular joint characteristics based on the 3D model of the patient's face, and derive digital articular settings for a digital articular based on the 3D model of the patient's dentition with the 3D data of the patient's face and the estimate of the temporomandibular joint characteristics.

INTRAORAL SCANNING GUIDANCE

Resumen de: US20260114968A1

A system comprises an intraoral scanner comprising one or more cameras that define a field of view (FOV) of the intraoral scanner, and a computing device. The computing device is configured to: process intraoral scans to generate a three-dimensional (3D) surface of a dental site during an intraoral scanning session; output a representation of the 3D surface to a display; determine a current position and orientation of the FOV of the intraoral scanner relative to the 3D surface; output a representation of the FOV of the intraoral scanner at the current position and orientation relative to the 3D surface to the display; determine suggested next positions and orientations of the FOV of the intraoral scanner relative to the 3D surface; and output the suggested next positions and orientations of the FOV of the intraoral scanner relative to the 3D surface to the display.

Method, apparatus, and computer-readable recording medium for providing orthodontic status and orthodontic treatment evaluation information based on dental scan data of patient

Resumen de: US20260114957A1

0000 The present invention provides a method for providing an orthodontic status and orthodontic treatment evaluation information based on dental scan data of a patient, implemented in a computing device including one or more processors and one or more memories storing instructions executable by the processors. The method is characterized by comprising: an initial image acquisition step of, when first dental scan data, which is three-dimensional scan data acquired by photographing the patient's head, is received, acquiring a first dental image, which is an image of the patient's teeth arrangement, on the basis of the received first dental scan data; a correction image acquisition step of, when the acquisition of the first dental image is completed, confirming a teeth arrangement status based on the first dental image through a pre-stored algorithm, and acquiring treatment solution information for correcting the teeth arrangement based on the confirmed teeth arrangement state, wherein acquired is a second dental image, which is an image of predicted teeth arrangement upon completion of the correction based on the acquired treatment solution information; an orthodontic appliance design creation step of, when the acquisition of the second dental image is completed, creating a design of a transparent orthodontic appliance for correcting the patient's teeth arrangement into a teeth arrangement corresponding to the second dental image; an intermediate image acquisition step of,

PHOTOCURABLE RESIN, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Resumen de: WO2026086601A1

The present application belongs to the technical field of photocuring 3D printing. Disclosed are a photocurable resin, and a preparation method therefor and the use thereof. The photocurable resin provided in the present application comprises a polyurethane acrylate oligomer, a modified acrylate oligomer, a reactive diluent, a photoinitiator, a light stabilizer and a dye, wherein the polyurethane acrylate oligomer can improve the toughness and reaction speed of the photocurable resin and reduce the volume shrinkage of the photocurable resin; the modified acrylate oligomer can improve the durability of the photocurable resin, adjust the hardness and toughness, and also reduce the volume shrinkage of the photocurable resin; and the reactive diluent can improve the hardness and toughness of the photocurable resin. The compounding of the polyurethane acrylate oligomer, the modified acrylate oligomer and the reactive diluent is used, and the amount of each component is defined, such that each component fully exerts a synergistic effect, and the photocurable resin maintains high toughness and durability while having a relatively low volume shrinkage and a relatively high hardness.

Olfactory Diagnostic Compositions and Kits, and Methods of Making and Using the Same

Resumen de: US20260114787A1

0000 The present invention is directed to olfactory diagnostic testing compositions and kits for detecting, screening and/or monitoring the progression of specific disease states or other conditions in a subject. In one aspect, the invention is directed to a method and testing kit using a pathology-specific panel of fragrances to detect, screen and/or monitor a specific disease state or condition. In another aspect, the invention is directed to a method of making diagnostic compositions having a specific complex fragrance such as an essential oil fragrance and diagnostic testing kits including such diagnostic compositions.

REPOSITION AND PENETRATION FORCEPS AND EXTERNAL FIXATOR FOR FRACTURES OF LONG BONES

Resumen de: US20260114904A1

Reposition and penetration forceps for fractures of long bones, in particular traumatic fractures of tibia in centre line, that comprise two jaws forming a three-point system in opposition, wherein the first movable jaw (1) comprises two threaded pins (7) with tips (21) and the second firm jaw (2) comprises one threaded pin (7) with a tip (21). An external fixator for fractures of long bones, in particular traumatic fractures of tibia in centre line, which comprises at least two sets of forceps, wherein the sets of forceps are arranged identically or in a mirror image to each other.

SYSTEMS AND METHODS FOR MANAGING GLYCEMIC VARIABILITY

Resumen de: US20260120863A1

Methods and apparatus, including computer program products, are provided for processing analyte data. In some example implementations, a method may include generating glucose sensor data indicative of a host's glucose concentration using a glucose sensor; calculating a glycemic variability index (GVI) value based on the glucose sensor data; and providing output to a user responsive to the calculated glycemic variability index value. The GVI may be a ratio of a length of a line representative of the sensor data and an ideal length of the line. Related systems, methods, and articles of manufacture are also disclosed.

PAPER-BASED WEARABLE PATCHES FOR REAL-TIME, QUANTITATIVE LACTATE MONITORING

Nº publicación: US20260114758A1 30/04/2026

Solicitante:

TRUSTEES OF TUFFS COLLEGE [US]
Trustees of Tuffs College

Resumen de: US20260114758A1

Disclosed herein is a printable liquid lactate sensor composition including silk fibroin in an amount by weight of between 0.1% and 30%, a lactate oxidase that is activated by lactate to produce hydrogen peroxide, a peroxidase that is activated by the hydrogen peroxide, and a chromogenic substrate that changes color upon activation of the peroxidase. Wearable sensors including the printable liquid lactate sensor composition are disclosed herein.