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3D打印金属植入物

Resumen de: CN223111858U

本实用新型公开了3D打印金属植入物，包括植入物主体。本实用新型通过采用了顶部件、中部件、底部件，作业时，通过3D打印机可以分批次的将顶部件、中部件以及底部件进行3D生产出来，接着将生产出来的多组部件可以通过底部的限位环与顶部的定位槽进行对接就可以实现多组结构的初步连接操作，接着转动结构可以使得孔洞相互对齐，然后在孔洞中安装上紧固螺栓，通过紧固螺栓就可以实现多组结构的固定操作，由于构成植入物主体的结构采用模块化的设置，因此在生产过程中容错率大幅度提升，可以在某一部件出现不合格时针对性的进行替换生产，不需要整个结构进行重新生产，有效的提升了整体的使用灵活性以及实用性，具有生产容错率高、使用灵活的优点。

基于人工智能的髓腔固位冠制造方法、系统

Resumen de: CN120326941A

本发明涉及牙冠制造技术领域，具体涉及基于人工智能的髓腔固位冠制造方法、系统，基于人工智能的髓腔固位冠制造方法包括：获取口腔CBCT影像与口扫模型；将口腔CBCT影像与口扫模型合成为合成模型；将合成模型输入训练后的AI模型，由AI模型基于合成模型生成髓腔固位冠模型；对髓腔固位冠模型做模拟受力测试，当髓腔固位冠模型的任意区域的应力大于预定值时，重新生成髓腔固位冠模型；对模拟受力测试合格的髓腔固位冠模型做模拟试戴测试；根据模拟试戴测试的结果调整髓腔固位冠模型；将调整后的髓腔固位冠模型输入打印装置并打印生成半成品髓腔固位冠；对半成品髓腔固位冠进行固化处理，生成成品髓腔固位冠。本申请提高了患者体验。

一种FARSs的数字化设计及制作方法及FARSs

Resumen de: CN120324131A

本发明公开了一种FARSs的数字化设计及制作方法及FARSs，该方法包括：获取使用者静态的上下颌牙列数字化三维模型、颌骨数字化三维模型及下颌动态运动数据，并在CAD/CAM软件内进行拟合，以构建使用者的动态VDP模型；基于使用者的动态VDP模型，确定使用者的治疗颌位，并导出对应于各治疗颌位的数字化三维牙列模型；依据所导出的各治疗颌位对应的数字化三维牙列模型，在CAD/CAM软件内中完成牙合面具有解剖形态的FARSs的个性化设计；根据个性化FARSs的设计数据，使用3D打印技术一次性完成FARSs的制造。本发明制作的FARSs通过全数字化流程制作，相比传统前伸再定位咬合板，个性化位置精度高，贴合性好，舒适度高，可以改善咀嚼功能；其次，序列治疗降低治疗难度、减少患者复诊次数。

纳米羟基磷灰石/聚酰胺66复合材料的成型方法及应用

Resumen de: CN120326930A

本发明公开了纳米羟基磷灰石/聚酰胺66复合材料的成型方法及应用，其中，纳米羟基磷灰石/聚酰胺66复合材料的成型方法，包括：成型，采用熔融沉积成型的挤出式3D打印机对含纳米羟基磷灰石/聚酰胺66复合材料的料浆进行3D打印成型，得到打印件；后处理，对所述打印件依次进行干燥和退火，得到纳米羟基磷灰石/聚酰胺66复合材料的成型件。本申请利用3D打印可基于患者CT数据的三维重建技术可定制椎体假体形态，实现与复杂解剖结构的精确匹配，避免标准化椎体假体的局限性；还能够精确设计孔隙结构，而羟基磷灰石本身具备微观孔隙结构(<10μm)，从而使产品具备多级孔隙结构，有利于加速骨整合。

一种具有活性的骨缺损修复材料及其制备方法

Resumen de: CN120324678A

本发明公开了一种具有活性的骨缺损修复材料及其制备方法。所述骨缺损修复材料由动物来源提取的胶原蛋白、煅烧骨基质及骨形态发生蛋白复合微球复合，通过光固化3D打印技术成型制成。本发明从仿生角度出发，拟以胶原蛋白作为框架材料，以免疫原性低的煅烧骨基质作为硬质材料增强材料力学支持，并辅以骨形态发生蛋白复合微球协同作用，长效引导未分化间充质干细胞向特定方向发展。该活性骨缺损修复材料，植入骨缺损部位后，为细胞提供一个利于细胞粘附和增殖微观环境，同时骨形成发生蛋白的缓慢释放，能够长效作用于骨缺损部位，有效地推动成骨细胞分化成熟的过程，促进骨缺损部位的骨修复。

光開始剤、それを含むバイオインク及びハイドロゲルの製造方法

Resumen de: US2025222169A1

The present disclosure relates to a photoinitiator, a bioink including the same, and a method of manufacturing a hydrogel. According to the present disclosure, the photoinitiator of the present disclosure may have water solubility, high molar extinction coefficient, and low cytotoxicity. In addition, the method of manufacturing a hydrogel of the present disclosure may have high cell viability by increasing 3D printing efficiency due to a fast photo-curing rate.

ORTHODONTIC TEETH-STRAIGHTENER MADE OF SHAPE-MEMORY POLYMERS, AND METHOD FOR THE PRODUCTION OF SAME

Resumen de: US2025228647A1

An orthodontic teeth-straightener, comprising a splint element which contains, or is entirely made from, a thermoplastic polyurethane having shape-memory properties. The thermoplastic polyurethane having shape-memory properties is selected from the group of polyether polyurethanes and contains hard segments which contain polyurethane units that have been obtained by polyaddition of the isocyanate groups of a diisocyanate to the hydroxyl groups of a diol acting as a chain extender, thereby forming urethane groups. The polyether polyurethane also contains soft segments, which contain, or are entirely made from, polyether units in the form of polyalkylene glycols, wherein the polyether units are bonded to isocyanate end groups of the diisocyanate of the hard segments, thereby forming urethane groups with the hard segments. The thermoplastic polyether polyurethane is both thermo-responsive and water-responsive and thus gives the splint element dual-stimuli responsive shape-memory properties.

BIOMANUFACTURING SYSTEM, METHOD, AND 3D BIOPRINTING HARDWARE IN A REDUCED GRAVITY ENVIRONMENT

Resumen de: US2025230391A1

A method, apparatus, and system are provided for the printing and maturation of living tissue in an Earth-referenced reduced gravity environment such as that found on a spacecraft or on other celestial bodies. The printing may be three-dimensional structures. The printed structures may be manufactured from low viscosity biomaterials.

光硬化性組成物及び歯科用製品

Resumen de: JP2023143923A

To provide a photocurable composition which can yield a cured product with the suppressed formation of cracks and breaks and excellent handleability.SOLUTION: A photocurable composition includes a (meth)acrylic monomer component and a photopolymerization initiator, wherein the adhesive force of its cured product is less than or equal to 1.5 N, and the rupture elongation of the cured product is greater than or equal to 20%.SELECTED DRAWING: Figure 1

Surgical Implant And Methods Of Additive Manufacturing

Resumen de: US2025228594A1

A method of manufacturing a surgical implant includes simultaneously forming a first component and a second component of the surgical implant. Formation of the first and second components includes depositing a first quantity of material to a building platform and fusing the first quantity of material to form a first layer of the first and second components. The method of manufacturing also includes depositing a second quantity of material over the first layer of the first and second components and fusing the second quantity of material to form a second layer of the first and second components. The surgical implant is fully assembled upon the completion of the formation of the first and second components.

3D PRINTED ARTIFICIAL BILE DUCTS AND MANUFACTURING METHOD THEREOF

Resumen de: US2025229006A1

The present invention relates to an artificial bile duct comprising ursodeoxycholic acid (UDCA), and due to comprising UDCA, the artificial bile duct of the present invention is effective in improving differentiation into cholangiocytes and preventing formation of bile stones.

LIQUID WITH PATTERN AND PRODUCTION METHOD FOR SAME

Resumen de: AU2023419073A1

The purpose of the present invention is to provide: a liquid with a pattern, said liquid including a pattern that can produce, in a liquid matrix, a sensation such as a color, a flavor, a texture, or a tactile sensation, said pattern having good stability; and a method for producing a liquid with a pattern which makes it possible to stably form a pattern in a liquid matrix. The present invention relates to, for example, a liquid with a pattern, said liquid including, in a liquid matrix, a pattern formed by microparticles and/or a pigment, wherein the liquid matrix is pseudoplastic fluid and is accommodated in a container.

AUTOMATED ORTHODONTIC ALIGNER MANUFACTURING AND ASSESSMENT

Resumen de: US2025229463A1

A manufacturing system comprises a holder, a robot arm, a press and a laser. The holder is configured to receive a feature of a dental appliance and to hold the dental appliance by clamping the feature of the dental appliance, wherein the holder holds the feature of the dental appliance at a reference position. The robot arm is configured to retrieve an object and to place the object against the feature at the reference position. The press is configured to apply pressure to press the object against the feature of the dental appliance while the dental appliance is held by the holder. The laser is configured to expose an interface of the dental appliance and the object to coherent light to weld the object to the feature of the dental appliance while the press presses the object against the feature of the dental appliance.

REMOVABLE DENTAL APPLIANCE INCLUDING SPRING MEMBER AND COMPUTER METHOD OF DESIGNING SAID APPLIANCE

Resumen de: EP4585185A2

The present invention relates to a method comprising forming a model of dental anatomy of a patient; and forming, based on the model, a removable dental appliance. The dental appliance comprises an appliance body configured to at least partially surround a plurality of teeth of a dental arch of a patient. The appliance body comprisies a unitary material defining a shell shaped to receive at least one tooth of the patient and a spring member integrally formed with the shell. The spring member is configured to receive an attachment, wherein the attachment is configured to affix to the at least one tooth, and wherein the spring member is configured to apply a spring force to the attachment to cause at least one of a rotation, a translation, a tipping, a torqueing, an extrusion, or an intrusion of the at least one tooth toward a desired position of the tooth when the removable dental appliance is worn by the patient.

フィルム製剤の製造方法及びフィルム製剤の製造システム

Resumen de: WO2023234310A1

This production method for a film preparation comprises: (1) a step for discharging a solution containing at least one pharmaceutical active ingredient from a print head to print the solution onto a soluble substrate film, the pharmaceutical active ingredient being printed onto the soluble substrate film so that the film includes a dose by which a desired effect is exhibited upon administration to a subject. The printed soluble substrate film can be formulated as a drug delivery system selected from a group including an injectable agent, a suppository, and a transdermal patch. The present invention also provides a production system for a film preparation, the system being for implementing the method.

TRANSFER APPARATUS FOR ORTHODONTIC APPLIANCES AND RELATED METHODS OF MANUFACTURING

Resumen de: CN119855708A

A method of manufacturing a transfer device includes providing a physical physical model having a shape corresponding to a positive shape of a patient's dental arch and one or more stent assemblies each including a lifting mechanism body releasably connectable to an orthodontic appliance. A transfer device may be formed over the physical entity model, wherein a transfer denture represents a negative replica of at least a portion of the entity model. The transfer device may be used to place the appliance on a patient's dental arch, after which the appliance may be detached from the lifting mechanism body and bonded to the associated tooth.

REMOVABLE DENTAL APPLIANCE INCLUDING SPRING MEMBER AND COMPUTER METHOD OF DESIGNING SAID APPLIANCE

Resumen de: EP4585184A2

The present invention relates to a system comprising an ordered set of removable dental appliances configured to reposition one or more teeth of a patient. Each removable dental appliance in the set of removable dental appliances comprises an appliance body configured to at least partially surround a plurality of teeth of a dental arch of a patient. The appliance body comprises a unitary material defining a shell shaped to receive at least one tooth of the patient and a spring member integrally formed with the shell, wherein the spring member is configured to receive an attachment. The attachment is configured to affix to the at least one tooth. The spring member is configured to apply a spring force to the attachment to cause at least one of a rotation, a translation, a tipping, a torqueing, an extrusion, or an intrusion of the at least one tooth toward a desired position of the tooth when the removable dental appliance is worn by the patient.

光硬化性組成物および放射線を対象に送達する方法

Resumen de: AU2023293120A1

The disclosure is directed in part to polymerizable biocompatible or bioabsorbable compositions comprising styrene, N-vinylpyrrolidone or acrylate monomers, further comprising epoxide, urethane, polyether, or polyester oligomers and free radical initiators that can incorporate a radioactive source, including diagnostic or therapeutic radioisotopes and radioisotope precursors, to treat subjects with certain conditions, and methods of producing and use thereof.

牙颌模型

Resumen de: CN223095648U

本实用新型公开一种牙颌模型，为由薄壁围合而成的底面开口的空心模型，包括牙颌部、与牙颌部一体成型的用于支撑牙颌部的底座部，以及设置在底座部内用于提升牙颌模型抗压强度的加强结构，薄壁包括唇颊侧壁和舌侧壁，加强结构横跨牙颌模型的空心部分设置，且加强结构的一端支撑在唇颊侧壁内表面的第一预设位置处，加强结构的另一端支撑在舌侧壁内表面的第二预设位置处；第一预设位置和第二预设位置对应于同一牙齿设置，第一预设位置和第二预设位置分别设置在至少对应于患者左右两侧尖牙至第二双尖牙的下方且与对应牙齿的牙龈线呈预设距离设置；其中，薄壁的厚度为0.5mm‑3mm，加强结构呈柱状，加强结构横截面的特征直径为0.5mm‑3mm。

一种悬空设计的3D打印脑部穿刺导板

Resumen de: CN223095603U

本实用新型涉及医用辅助器械，一种悬空设计的3D打印脑部穿刺导板，包括导板本体；导板本体包括与患者的骨性生理特征相适配的眉弓固定曲面和鼻根固定曲面，鼻根固定曲面由眉弓固定曲面的中段下侧朝下延伸形成，导板本体整体呈T型；导板本体还包括鼻头固定曲面和鼻侧悬伸曲面；鼻头固定曲面由鼻根固定曲面的下部朝下延伸形成，且能够包覆在患者鼻头上；鼻头固定曲面的一侧朝左/右延伸形成有鼻侧悬伸曲面；本实用新型通过眉弓固定曲面、鼻根固定曲面、鼻头固定曲面等进行多点固定，多点固定的形式使得整体的固定更加的稳定，相较传统的简单通过皮肤贴附固定的方式而言，不易产生位移，能够保证穿刺导向的精准性，防止体表组织移动造成的干扰。

通过基于光的结构化固化制备的用作乳房植入物的3D脂肪组织支架

Resumen de: WO2024120579A1

The invention relates to a 3D fat tissue structure for use as a breast implant for surgical, therapeutic, prophylactic or aesthetic reconstruction, construction or replacement of human breast tissue, wherein the 3D fat tissue structure has a matrix that is made of a biocompatible polymer and colonised with a plurality of biological cell types, wherein the colonisation with the plurality of cell types takes place during the construction of the matrix made of a biocompatible polymer, in the course of which a blood vessel structure network is formed within the 3D fat tissue structure, characterised in that, for the construction of the matrix made of a biocompatible polymer, light-based, structuring curing of a photopolymerisable or photocrosslinkable fluid is used. The invention also relates to the use of a 3D fat tissue structure as a breast implant in humans, wherein the 3D fat tissue structure has a matrix made of a biocompatible polymer, which is colonised with a plurality of cell types, wherein the colonisation with the plurality of cell types takes place during the construction of the matrix made of a biocompatible polymer, in the course of which a blood vessel structure network is formed within the 3D fat tissue structure, characterised in that, for the construction of the matrix made of a biocompatible polymer, light-based, structuring curing of a photopolymerisable or photocrosslinkable fluid is used.

一种基于3D打印的用于关节软骨快速配准的弹簧测针系统

Resumen de: CN120304949A

本发明公开了一种基于3D打印的用于关节软骨快速配准的弹簧测针系统，涉及医疗成像与骨科手术导航技术领域。为了解决传统CT成像中软骨无法显影导致的关节配准精度不足的问题；本发明通过3D打印导板个性化定制，定位孔方便安装，弹簧测针组件可调节且数据监测实时，智能配准模块自动处理数据，减少人工操作，提高了手术效率，弹簧测针组件结构合理、弹力可调节，保障了系统在手术中的稳定运行，多体位CT扫描结合先进图像处理和配准技术，构建精确初始模型，弹簧测针组件采集数据结合弹性形变补偿模型实时修正配准误差，提升了配准准确性，为骨科手术导航提供了可靠支持，有助于提高手术成功率，减少患者创伤和手术风险。

锆铌合金种植件和锆铌合金种植件制作方法

Resumen de: CN120304980A

本发明涉及种植牙技术领域，具体而言，涉及一种锆铌合金种植件和锆铌合金种植件制作方法。该锆铌合金种植件包括种植体以及基台；种植体的外周配置有连接螺纹；种植体外表层为多孔骨小梁结构，多孔骨小梁结构采用三周期极小曲面结构，且其孔隙相互联通；种植体的外表面覆有锆铌合金金属陶瓷；种植体内部配置连接腔，连接腔内配置连接部；基台配置有用于与连接部可拆卸地连接的锥形连接台，基台在定量压力下压入种植体，在定量拉力下拔出基台。该锆铌合金种植件的种植体表面的多孔结构设计可促进骨组织长入，实现假体与人体骨骼界面的牢固整合，提高假体的稳定性和使用寿命，而且种植体与基台连接稳固，并能够降低金属过敏反应和金属伪影。

一种仿天然角膜纤维排列的超低溶胀人工角膜及制备方法

Resumen de: CN120305460A

本发明提供一种仿天然角膜纤维排列的超低溶胀人工角膜及制备方法，属于生物医用材料技术领域，本发明将I型胶原蛋白溶解于PBS缓冲液中，加入光功能化修饰的活性试剂进行化学修饰，避光搅拌后冷冻干燥，得到光功能化胶原蛋白；将光功能化胶原蛋白溶解，然后通过静电纺丝制备胶原纤维膜；将生物墨水和胶原纤维膜进行相变DLP 3D生物打印，获得胶原纤维夹层结构的人工角膜。本发明通过DLP 3D生物打印实现多层排列，模拟天然角膜的纤维走向，显著提升力学各向异性；GelMA/HA‑DN与光交联胶原纤维的复合相变DLP 3D打印方式，使其具有良好的可制造性，维持高透光率，同时保持高力学强度。

一种纳米纤维纱线3D打印复合支架及其制备方法与应用

Nº publicación: CN120305453A 15/07/2025

Solicitante:

五邑大学

Resumen de: CN120305453A

本发明公开了一种纳米纤维纱线3D打印复合支架的制备方法，所述制备方法包括以下步骤：S1：将纺丝所需聚合物和/或无机源溶于对应溶剂，得到纺丝前驱体溶液；S2：使用步骤S1所述的纺丝前驱体溶液采用纳米纤维纺纱设备进行纺纱，得到纳米纤维纱线；S3：利用3D打印技术打印得到聚合物框架；S4：将S2中所述的纳米纤维纱线在S3所述聚合物框架中进行编织，得到纳米纤维纱线3D打印复合支架。该制备方法制备得到的支架不仅具有3D打印的几何结构，还具有纳米纤维的高比表面积和生物活性，能够更好地模拟天然组织的微环境，可以克服传统支架的局限性，提供了更理想的组织工程支架。