Alerta

CHEAP, PORTABLE, ELECTRICITY-FREE ELECTROPORATOR FOR GENE TRANSFER IN CELLS

Resumen de: WO2026010589A1

The invention is a cheap, portable, electricity-free electroporator for gene transfer in single cells. In order to transfer substances such as the gene DNA in cells, it generates electricity in during 20 microseconds in the range of about 200 volts to 5 kv. This causes a temporary opening of the cell pore in bacteria/cells and the targeted substance enters. The first part of the product: Cuvette holder: It is designed to hold the current electroporation cuvettes in a suitable size. The 2 copper connection cables from the piezoelectricity supply electricity to the cuvette. The second part of the product: Main case: It contains the 1st part of the product and also contains the piezoelectric system, cables, and button. It weighs approximately 30 grams and is a 3D printed single piece. Its dimensions are preferably 27 mm x 62 mm x 35 mm. The third part of the product: Button: Thanks to this button, electricity through piezo system is transferred to the cuvette with a single press.

DENTAL PROSTHESIS OR TEETH-STRAIGHTENING DEVICE CONTINUOUS PRODUCTION PROCESS USING 3D PRINTER, AND DENTAL PROSTHESIS OR TEETH-STRAIGHTENING DEVICE MANUFACTURED USING CONTINUOUS PRODUCTION PROCESS

Resumen de: WO2026010233A1

The present invention relates to a dental prosthesis or teeth-straightening device continuous production process using a 3D printer, and to a dental prosthesis or a teeth-straightening device manufactured using the continuous production process. The present invention is for manufacturing a patient-customized dental prosthesis or teeth-straightening device by using 3D data on the oral structure of a patient, wherein a teeth-straightening device is manufactured using 3D printing, supporter separation, washing, post-curing, and heat treatment processes are performed in a continuous process, and the steps proceed by means of a robot without manual handling by a person during proceeding of the steps, thereby improving production efficiency and enabling defective products to be sorted out without additional equipment.

USE OF GELATIN IN A SUPPORT MATERIAL FOR EMBEDDED PRINTING

Resumen de: WO2024218352A1

The current invention pertains to a use of gelatin in a support material for embedded printing. The current invention furthermore pertains to a method for preparing a gelatin support material for embedded printing and a gelatin support material, optionally obtainable by the method. The invention furthermore pertains to a method for embedded printing using a gelatin support material. In the context of the invention, the gelatin has an average molecular weight of 50 - 250 kDa and preferably is in a fluid bulk, single-phase and non-crosslinked form.

ADDITIVES FOR 3D PRINTING POLYMER RESINS

Resumen de: US2025346703A1

The present disclosure provides micelles comprising a plurality of block co-polymers, the micelle comprising (i) a core comprising at least a portion of a poly(alkyl acrylate) block of one or more of the block co-polymers; and (ii) an outer layer comprising at least a portion of a poly(aryl acrylate) block or a poly(aryl methacrylate) block of one or more of the block co-polymers. The present disclosure also includes polymer compositions, polymer films, and devices (e.g., orthodontic equipment) including the same. Methods for making and using micelles, polymer compositions, polymer films, and devices (e.g., orthodontic equipment) are also disclosed. Further provided herein are methods of producing polymer compositions and using the same for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.

CERAMIC VENEERS AND CONTINUOUS ADDITIVE MANUFACTURING METHOD FOR MAKING CERAMIC VENEERS

Resumen de: CN120857914A

The present disclosure provides a method of making a ceramic article. The method comprises (a) obtaining a photopolymerizable slurry or sol comprising a plurality of ceramic particles distributed in the photopolymerizable slurry or sol, and (b) continuously moving a build substrate through the photopolymerizable slurry or sol using actinic radiation, and selectively polymerizing the photopolymerizable slurry or sol to form a gelled article. The method further includes (c) extracting a solvent from the gelled article to form an aerogel article or a xerogel article; (d) heat treating the aerogel article or the xerogel article to form a porous ceramic article; and (e) sintering the porous ceramic article to form a sintered ceramic article. The sintered ceramic article exhibits a specific density. In addition, additive manufactured ceramic articles exhibiting specific density, opacity, or both are provided.

NOZZLE PLATE, FLUID EJECTION HEAD, FLUID EJECTION DEVICE, AND MODIFYING METHOD OF NOZZLE PLATE

Resumen de: EP4674624A1

A nozzle plate (128) configured for a fluid ejection head (114), a fluid ejection head (114) containing the nozzle plate (128), a fluid ejection device (100) containing the fluid ejection head (114), and a method for modifying a nozzle plate (128) for a fluid ejection device (100) to reduce fluid flooding thereon are provided. The nozzle plate (128) includes a plurality of nozzle holes (126) therein, the nozzle plate (128) being attached to a flow feature layer (124) on a semiconductor substrate (116), and the nozzle plate (128) includes a first hydrophobic region (150, 176, 186) surrounding each of the plurality of nozzle holes (126), whereby the first hydrophobic region (150, 176, 186) is configured to reduce flooding of the nozzle plate (128).

ELASTOMERIC SEAL-FORMING STRUCTURE WITH MULTIPLE CURVATURES

Resumen de: EP4674457A2

The present invention relates to a patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to a patient's airways including at least an entrance of a patient's nares. The patient interface is configured to maintain a therapy pressure in a range of about 4 cmH2O to about 30 cmH2O above ambient air pressure in use, throughout a patient's respiratory cycle, while the patient is sleeping, to ameliorate sleep disordered breathing. The patient interface comprises a plenum chamber at least partially forming a cavity pressurisable to a therapeutic pressure of at least 6 cmH2O above ambient air pressure. The plenum chamber includes a plenum chamber inlet port sized and structured to receive the flow of air at the therapeutic pressure for breathing by a patient. The patient interface further comprises a seal-forming structure having a textile membrane constructed and arranged to form a seal with a region of the patient's face surrounding the entrance to the patient's airways inferior to a nasal bridge region of the patient's face. Said textile membrane has at least one hole such that the flow of air at said therapeutic pressure is delivered to at least the entrance to the patient's nares. The seal-forming structure is constructed and arranged to maintain said therapeutic pressure in the cavity throughout the patient's respiratory cycle in use. The textile membrane comprises a first layer constructed

BIOPRINTING METHODS AND SYSTEMS

Resumen de: MX2025010283A

In a bioprinting system and method, a bioprinter may include one or more reservoirs, a printhead, and a print surface on which the bioprinting is dispensed. An optical system may collect imaging data of a plurality of cells within a cross-linkable material before, during and/or after passage of the plurality of cells through the bioprinting system. A computing system may process the imaging data to determine a quantity, distribution, concentration, and/or morphology of the plurality of cells. A machine learning system compares characteristics of the plurality of cells before, during and/or after passage of the plurality of cells through the bioprinting system to user-established cell morphologies corresponding to physical properties of cells and/or cell aggregates within a predetermined tolerance. Additionally or alternatively, the machine learning system compares characteristics of the plurality of cells at one stage in the bioprinting system to characteristics of the plurality of cells at another stage in the bioprinting system.

一种力学性能增强的3D打印角蛋白水凝胶支架及方法

Resumen de: CN121265863A

本发明公开了一种力学性能增强的3D打印角蛋白水凝胶支架及方法，属于生物材料加工和组织工程领域，将3D打印角蛋白水凝胶支架在自下而上的单向温度梯度环境中进行定向冷冻，之后浸没于‑80°C至‑20°C的醇类水溶液中，将水分子进行置换，得到初步处理的支架；之后浸泡在0°C~10°C且pH为4.0‑5.5的含盐离子缓冲溶液中，之后依次进行脱水、氧化和干燥，得到力学性能增强的3D打印角蛋白水凝胶支架，能在维持支架宏观形态的同时，在其内部可控地构建出高度有序的仿生层级结构，从而实现力学性能的巨大飞跃，并赋予其独特的各向异性。

一种正颌鼻模及其制造方法、正颌鼻模3D打印机

Resumen de: CN121265184A

本发明涉及医疗设备技术领域，特别涉及一种正颌鼻模，所述夹板本体中部设有鼻部凸起，鼻部凸起底部开有两个鼻孔，鼻孔内设有向鼻部凸起内延伸的管状凸起，管状凸起的长度为3‑5mm，鼻部凸起底部设有两个鼻翼凸起，鼻翼凸起环绕鼻孔设置，术前鼻翼半径与鼻翼凸起半径差值为1‑2mm，夹板本体底部设有基底夹板，基底夹板设置在鼻部凸起的下方，夹板本体每侧各纵向开有两个打孔，每个打孔均通过一个鸡眼扣与一个弹性绑带的端部连接，患者原鼻翼与鼻翼凸起的尺寸差值为1‑2mm，结构通过鼻翼凸起的设置对患者的术后鼻翼进行约束，配合鼻孔插管可以起到内收鼻翼、缩窄鼻翼宽度、增大鼻高度、改善鼻扁平、纠正两侧鼻孔欠对称的作用，提高术后塑形效果。

用于制造牙套的设备

Resumen de: WO2024254624A1

A device for producing a dental splint is described, comprising a computing unit (1), a thermoforming station (2) for a film on a denture model (3), and a laser cutting system (4) for cutting out the dental splint from the film. In order to configure a device of the type depicted at the outset in such a way as to enable a manufacturing process of dental splints which is as fully automated and rapid as possible, wherein, in particular, the space requirement of the required devices is minimized and complicated robotics systems for transporting the dental splints are intended to be dispensed with, it is proposed that a plurality of workstations are provided which comprise at least one 3D printer (5) for producing the denture model (3) on a workpiece carrier (10), the thermoforming station (2), a severing device (6) for severing the thermoformed film from the denture model (3), and the laser cutting system (4), wherein the workstations are arranged along a transport system (7) which comprises a guide (8) and a transport means (9) which is arranged movably along the guide (8) for loading and unloading the workstations with the workpiece carrier (10).

光敏氧化锆陶瓷浆料、牙齿贴面及制备方法

Resumen de: CN121270235A

本发明属于氧化锆陶瓷技术领域，公开一种光敏氧化锆陶瓷浆料、牙齿贴面及制备方法；所述光敏氧化锆陶瓷浆料，以质量百分比计包括：氧化锆粉末80‑92wt.%、紫外光敏树脂体系6‑18wt.%和分散剂0.1‑2.0wt.%。本发明光敏氧化锆陶瓷浆料为一种均匀、无气泡、高固含量、易于打印的光敏氧化锆陶瓷浆料；所述氧化锆粉作为陶瓷骨架，提供最终产品的强度、韧性和化学稳定性；所述紫外光敏树脂体系作为液态载体和粘结相，在特定波长紫外光照射下发生聚合反应，将陶瓷粉末粘结固化，形成打印坯体。本发明光敏氧化锆陶瓷浆料通过3D打印制备牙齿贴面，几乎无材料浪费，解决了CAD/CAM制造存在的材料浪费的技术问题，显著降低成本，实现40‑100μm超薄和复杂形态的牙齿贴面的直接制备，无崩边风险。

Ag-DCPD膜层表面涂覆掺杂Ca-Cur亚微米改性材料的PLA层的方法

Resumen de: CN121265874A

本发明公开了一种Ag‑DCPD膜层表面涂覆掺杂Ca‑Cur亚微米改性材料的PLA层的方法，涉及医用材料表面生物涂层技术领域。该方法包括：采用激光粉末床熔融增材制造技术制造LPBF‑NiTi合金基体并进行预处理；将预处理后的LPBF‑NiTi合金基体在电解质溶液中进行电化学沉积，得到沉积Ag‑DCPD膜层的LPBF‑NiTi合金基体；将CaCl2和姜黄素溶于无水乙醇，放入放有(NH4)2CO3的密闭容器恒温反应，得到Ca‑Cur亚微米改性材料；将聚乳酸溶于二氯甲烷，后将Ca‑Cur亚微米改性材料分散其中，得到浸提液；将沉积Ag‑DCPD膜层的LPBF‑NiTi合金基体在浸提液中反复浸渍提拉，得到涂覆Ag‑DCPD/PLA/Ca‑Cur复合膜层的LPBF‑NiTi合金基体。通过本发明，成功改善了Ag‑DCPD膜层的耐蚀性、生物相容性及抑菌抗炎性能。

异质结纳米复合材料及制备方法、异质结支架及制备方法和应用

Resumen de: CN121265857A

本发明涉及骨组织工程与智能抗菌材料交叉技术领域，具体涉及异质结纳米复合材料及制备方法、异质结支架及制备方法和应用。以pCu‑BTC和MoS2为原料，在分散介质中室温下进行球磨，然后冰浴条件下间歇式超声，形成II型异质结界面，得到异质结纳米复合材料，再复配左旋聚乳酸后经高压均质‑3D打印成型，得到超声响应型MoS2/pCu‑BTC/PLLA异质结支架。所述支架兼具声动力/化学动力双模式抗菌及促成骨功能，生物相容性好、降解可控，可广泛应用于感染性骨缺损修复领域，为“抗菌‑骨再生”协同治疗提供新型材料解决方案。

基于3D打印制备牙科修复体的方法及牙科修复体

Resumen de: CN121270067A

本发明提供了一种基于3D打印制备牙科修复体的方法及牙科修复体。该方法包括：将牙科修复体材料以均匀浆料的形态通过3D打印的方式打印，得到目标形状的生坯。将生坯进行脱脂，得到脱脂生坯；将脱脂生坯进行烧结，得到烧结坯体；将烧结坯体进行升温结晶，得到牙科修复体。考虑到脱脂后的生坯中虽然已经析出了一些晶相，但是由于升温速率快以及没有经过保温，因此晶相的含量较低并且玻璃相的含量依然较高，在玻璃相含量较高的情况下材料的烧结会变得容易。本发明采用较快的升温速率、较高的烧结温度以及较短的烧结时间完成烧结。如此，不仅缩短了脱脂和烧结时间、提高了生产效率，并且还可以保证牙科修复体的轮廓不变形，满足密合度要求。

一种互穿相陶瓷牙科材料的制备方法

Resumen de: CN121270239A

本发明公开了一种互穿相陶瓷牙科材料的制备方法，属于生物医用材料技术领域。本发明基于鸟类骨骼的多孔泡沫结构及空腔组织进行仿生设计，建立了两种结合环状舌骨结构特征与空腔组织的仿生鸟骨结构，并依据鸟类头骨协同减振机理进行榫卯配合设计，构建了具有协同承载与缓冲特性的仿生鸟骨榫卯结构，该结构相较于传统结构具有更优异的力学承载性能与变形稳定性。通过光交联的方法制备的氧化锆‑水凝胶互穿相材料，软相与硬相材料的复合设计不仅显著提升了材料的吸能特性，同时有效改善了牙科材料的断裂韧性。在此基础上，采用溶胶‑凝胶浸涂工艺在材料表面构筑功能性涂层，进一步解决了牙科材料在口腔环境中耐腐蚀性与耐磨性不足的问题。

用于生产氧化锆牙科制品的方法

Resumen de: WO2024231752A1

The invention relates to a process of producing a dental zirconia article, the process comprising the steps of processing a radiation-curable zirconia sol A as construction material in an additive-manufacturing process comprising a radiation-curing step to obtain a zirconia gel article, the zirconia gel article having the shape of a dental article with an outer and an inner surface, applying a radiation-curable zirconia sol Bx on at least a portion of the outer surface of the zirconia gel article,radiation-curing the radiation-curable zirconia sol Bx of step (b), transforming the zirconia gel article into a zirconia aerogel article, the radiation-curable zirconia sol A being same or different from the radiation-curable zirconia sol Bx with respect to chemical composition and/or physical properties. The invention also relates to a dental ceramic zirconia article obtainable by the process described in any of the proceeding claims.

三次元微細孔性フィラメント構成体の製造方法

Resumen de: CN120265403A

A method for producing a three-dimensional macroporous filament construct having interconnected microporous filaments comprises: a) preparing a mixture comprising particles of one or more metals, one or more metal alloys, or a combination thereof, one or more binders, a first liquid solvent of the one or more binders, and optionally one or more dispersants; b) dispersing particles containing at least one removable additive in the mixture; c) depositing the mixture in the form of filaments in a predetermined three-dimensional pattern of interconnected filaments, thereby producing a filament-based three-dimensional porous green structure; d) contacting the filament-based three-dimensional porous green structure formed in step c) with a second solvent, which is a non-solvent for the one or more binders, to induce phase inversion, thereby producing a filament-based phase-inverted porous structure having filament micropores, thereby converting at least a portion of the filaments into a solid state; e) removing the at least one removable additive by dissolution in a remover to create additional micropores in the phase-inverted porous structure; f) subjecting the structure thus obtained to a heat treatment. The remover contains or consists of the second liquid solvent, or the remover is a third liquid solvent different from the second liquid solvent.

一种光固化3D打印用硅酸钙基生物活性陶瓷浆料及其制备方法

Resumen de: CN121265855A

本发明涉及生物医用材料增材制造技术领域，具体涉及一种光固化3D打印用硅酸钙基生物活性陶瓷浆料及其制备方法。该浆料由以下质量份的原料组成：硅酸钙基生物陶瓷粉末50‑70份、活性单体15‑30份、低聚物8‑15份、光引发剂0.5‑2.5份、润湿分散剂1‑3份、流平剂0.5‑2份。本发明通过选用具有特定形貌和粒径分布的硅酸钙基陶瓷粉末，成功解决了生物陶瓷浆料因密度大、表面极性高而导致的易沉降、粘度高、固化层脆性大等问题。所制备的浆料具有生物活性高、粘度适宜、稳定性佳、固化后生坯强度高及打印精度好等特点，特别适用于制备具有复杂多孔结构的骨修复支架，经打印、清洗、烧结后，可获得力学性能良好、降解速率可控且具有优异生物活性的陶瓷构件。

一种基于水-水乳浊液的3D打印多孔水凝胶及其制备方法和应用

Resumen de: CN121270960A

本发明涉及一种基于水‑水乳浊液的3D打印多孔水凝胶及其制备方法和应用，涉及生物医学技术领域。是通过水凝胶前驱体经过光固化交联形成，水凝胶前驱体包括连续相介质和分散相介质，连续相介质和分散相介质的体积比为1:（2～5）。本申请提供的水凝胶突破连续相介质和分散相介质常规的体积比，打破了传统水‑水两相乳浊液带来的体积比例限制，制备而成的水凝胶具备多层级孔径，并且水凝胶的光固化成型性能、3D打印成型性能、溶胀性能及力学性能均优于现有通过高体积连续相介质制备而成的水凝胶，从而为制备更高孔隙及连通性的水凝胶提供了新的技术体系。

一种基于3D打印技术的尼古丁分级释放口含制剂及其制备方法

Resumen de: CN121264688A

本发明涉及一种基于3D打印技术的尼古丁分级释放口含制剂及其制备方法。所述尼古丁分级释放口含制剂为球状结构，由内至外依次仅包含长效核心层、缓释中间层和速释表层，三层通过3D打印技术一体成型；所述长效核心层、缓释中间层和速释表层均包括负载活性组分的多孔载体；且长效核心层、缓释中间层和速释表层中多孔载体的孔径依次增加；所述活性组分选自尼古丁、或其异构体、或其药学上可接受的盐。本发明通过3D打印技术实现了尼古丁三级释放的精准调控，实现了“快速起效‑持续维持‑长效收尾”的三级释放模式，起效快，满足感强，低剂量长效维持，尼古丁摄入不易过量，同时能够减少刺激性，且制备得到的口含制剂具有优异的储存稳定性。

用于纠正替牙期单侧正锁合的3D打印矫治装置

Resumen de: CN121265289A

本发明公开了一种用于纠正替牙期单侧正锁合的3D打印矫治装置，包括上颌矫治组件和下颌矫治组件；上颌矫治组件包括适配于正锁合侧牙列的3D打印金属联冠、适配于非正锁合侧及腭侧的树脂基托、以及连接3D打印金属联冠与树脂基托的螺旋扩弓器，螺旋扩弓器被配置为对正锁合侧牙列施加缩弓力；下颌矫治组件包括下颌3D打印金属支架和下颌树脂固位层，下颌3D打印金属支架在非正锁合侧形成金属带环结构，在正锁合侧延伸形成长臂钩结构，下颌树脂固位层包覆于所述金属带环结构的外表面及非正锁合侧牙齿表面。本发明利用数字化设计与3D打印技术定制，通过粘接剂固定于口内，具有固位力好、体积小、对患者依从性低、能有效防止后牙伸长及缩短治疗周期的特点。

WATER BOLUS WITH WATER VOLUME FLOW CONTROL

Resumen de: WO2026005610A1

Water bolus (200) for covering part of an outer body surface of a body part, the water bolus comprising: - a flexible cover (202) for forming at least part of a container for containing a liquid; and - an insert (100) provided inside the flexible cover, wherein the insert is formed by interconnected struts (102) which form an open structure through which a liquid can flow.

IMPLANT TECHNIQUES

Resumen de: WO2026006035A1

A system (100) includes a bioprinter (110) having a nozzle (116) that is transluminally advanceable to the heart via a catheter (120). The bioprinter houses a bioink (140) comprising a biomaterial (142). While the nozzle extends from a distal portion (124) of the catheter, the nozzle can extrude the bioink into the heart such that the biomaterial assumes a three-dimensional implant-shape. Other embodiments are also described.

DESIGN AND FABRICATION OF PATIENT-SPECIFIC RADIATION THERAPY COLLIMATOR HOLDERS

Nº publicación: WO2026006303A1 02/01/2026

Solicitante:

MAYO FOUNDATION FOR MEDICAL EDUCATION AND RES [US]
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH