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用于制造牙科物件的方法

Resumen de: US2025375273A1

A method of producing a dental object, including the steps of printing (S101) a substructure; printing (S102) an intermediate layer from a support material on the substructure; and printing (S103) the dental object from the production material for the dental object on the intermediate layer.

用于3D打印树脂的可光固化聚合物和组合物

Resumen de: US2024400859A1

The present disclosure provides a miktoarm polymer having the following structure:where polymer chain 1, 2, 3, 4, A1 and A2 are as defined herein. These miktoarm polymers can produce desirable polymeric materials and being used as a component in photo-curable resins. Further provided herein are methods of producing miktoarm polymers, as well as compositions, resins, devices, and polymeric materials by use of the same. Also provided herein are methods of using miktoarm polymers, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.

用于制造牙科物件的方法

Resumen de: US2025375921A1

A method of producing a dental object, including the steps of printing (S101) a printing layer of the dental object; evaporating (S102) a solvent of the printed printing layer; and detecting (S103) a temperature profile during evaporation of the solvent.

一种形状记忆型多孔的墨水直写打印植入介入类微型医疗器械制品及其制备方法

Resumen de: CN121102591A

本发明提供一种形状记忆型多孔的墨水直写打印植入介入类微型医疗器械制品及其制备方法，是将十二烷二酸与甘油经真空条件下搅拌反应制备得到PGD预聚物，然后加入水溶性无机盐颗粒后经固化得到打印用PGD墨水材料，利用墨水直写3D打印成型，再经固化、去除水溶性无机盐颗粒、冷冻干燥制备得到植入介入类微型医疗器械制品。本发明通过耦合墨水直写打印与PGD制备植入介入类微型医疗器械制品，并基于颗粒渗滤法首次利用水溶性无机盐颗粒赋予PGD基制品多孔结构特征与可药物负载性，实现了临床愈合所需的机械强度和药物负载特性的精确调节战略的有效方案，尤其是为椎间盘退变相关研究相关植入类微型医疗器械制品提出了新思路。

用于制造牙科物件的方法

Resumen de: US2025375275A1

A method of producing a dental object (100), including the steps of printing (S101) the dental object by means of a production material and a support structure by means of a meltable support material layer by layer; melting (S102) the support material; and absorbing (S103) the molten support material in the production material of the printed dental object.

一种具有区域差异化物理性能的牙科矫治器及其增材制造方法

Resumen de: CN121101779A

本发明涉及牙科医疗器械领域，公开了一种具有区域差异化物理性能的牙科矫治器及其增材制造方法。该矫治器包括由光固化树脂制成的三维壳体结构，所述树脂含有聚氨酯丙烯酸酯和单体。通过调节打印工艺参数，使基体不同区域获得差异化的力学性能，从而在同一矫治器内对不同牙齿施加方向和大小不同的矫治力，以满足临床复杂需求。所述矫治器的材料性能包括：拉伸模量420～2650MPa、屈服强度22～78MPa、屈服应变大于1.8%、断裂应变大于10%、玻璃化转变温度大于40℃，且平均厚度小于2.0mm。本发明方法工艺简便，可提高矫治精度与生物相容性，提升治疗效率。

一种复合材料及快速制备方法

Resumen de: CN121108714A

本发明涉及生物导电技术领域，具体涉及一种复合材料及快速制备方法。本发明提供了一种面向生物电子学的新型柔性导电复合材料，其通过将混合体系进行光照成型制备得到。本发明以聚醚F127‑二丙烯酸酯作为弹性网络骨架，溶解在导电聚合物溶液中均匀掺杂导电聚合物，制备得到半互穿双网络水凝胶；随后通过温和冰醋酸处理去除多余小分子并诱导链段重新排列。本发明制备出的生物柔性导电材料具有优异的导电性、机械性能和生物相容性，可以结合3D打印技术来获得具有良好性能的生物柔性电极。本发明从材料体系到制造工艺改进了现有柔性电极导电性低、封装复杂和大尺寸打印受限的瓶颈，为可植入软生物电子学提供了通用、高效的新方案。

一种显微镜下腰椎手术个性化定制软组织保护装置

Resumen de: CN121101769A

本发明涉及一种显微镜下腰椎手术个性化定制软组织保护装置，包括通路主体、紧缩闭合件和撑开固定件；通路主体包括套筒，套筒侧壁设有沿其轴向延伸的开口，开口两侧壁面的外部对称设置有滑轨；紧缩闭合件包括顶盖和连接在顶盖下的紧缩部件，紧缩部件内侧对称设置有两个与所述滑轨适配的滑槽Ⅰ；撑开固定件包括外侧弧形片、内侧弧形片及连接在外侧弧形片与内侧弧形片之间的撑开部，撑开固定件周向的两侧设有滑槽Ⅱ，滑槽Ⅱ能套设在套筒开口两侧壁面上并沿套筒开口处轴向滑动。本发明结构简单，操作方便，能根据需要的视野范围选择不同规格的撑开固定件使套筒被撑开至理想尺寸，可以个性化定制，与患者身体情况高度适配，可提高手术操作效率，减少并发症和不适情况的发生。

用于预测牙齿移动和制造正畸器具的系统和方法

Resumen de: WO2024238462A2

A computer-implemented method for predicting tooth positions includes a) defining a plurality of tooth positions corresponding to a plurality of teeth in a dental arch; b) defining a plurality of appliance positions of an orthodontic appliance; c) determining, for each tooth, one or more tooth position differences; d) determining, for each tooth, one or more appliance position differences; e) determining, for each tooth, one or more appliance-tooth relative differences; f) modifying each of the plurality of tooth positions based on the corresponding one or more appliance-tooth relative differences; g) iteratively repeating steps c) to f) until a maximum change in each of the plurality of tooth positions is less than a convergence threshold; and h) defining the plurality of tooth positions obtained in the final iteration of step g) as a plurality of predicted tooth positions.

用于骨缺损修复的可降解梯度多孔Zn@β-TCP复合材料支架及制备方法

Resumen de: CN121104087A

本发明属于金属粉末加工技术领域，公开一种用于骨缺损修复的可降解梯度多孔Zn@β‑TCP复合材料支架及制备方法。其中，支架的Zn@β‑TCP复合材料中，优选Zn和β‑TCP的体积分数为97vol.%和3vol.%；支架内部结构为梯度多孔结构，具体是以三周极小曲面为孔隙拓扑结构，孔隙直径为700±50μm～1100±50μm线性过渡。制备方法为通过计算机辅助设计出梯度多孔支架模型，以Zn为金属基体，β‑TCP为增强相，利用激光粉末熔融技术制备出具有梯度多孔结构的Zn@β‑TCP复合材料支架。本发明制备支架中梯度结构设计能够为成骨细胞的黏附、增殖提供更大的空间，有利于营养物质的传输和骨组织的长入。

MINIATURIZED TABLET COATING APPARATUS AND METHOD

Resumen de: WO2025255124A1

A method is provided for coating tablets on-demand in a miniaturized coating apparatus. A supply of tablets are provided, each having dimensions and a mass. The supply of tablets together has a total number, a total mass and a total volume. In some aspects, specifications are selected for constructing a customized rotatable drum based on tablet dimensions, tablet number, total mass, total volume, physical and/or chemical properties of coating material(s) to be applied to the tablets, or a combination thereof. In some embodiments, the rotatable drum may be formed by 3D printing.

SCHLIESSEN VON LÖCHERN IN EINEM DREIDIMENSIONALEN DIGITALEN PRÄPARATIONSMODELL

Resumen de: DE112024000859T5

Enthalten ist ein computerimplementiertes Verfahren zum Schließen eines oder mehrerer Löcher in einem unteren Abschnitt eines dreidimensionalen digitalen Präparationsmodells einer Zahnpräparation. Der Zahn ist für die Aufnahme eines Zahnrestaurationselements präpariert, wobei eine untere Grenze des unteren Abschnitts der Präparation in Form einer stufenlosen Kante präpariert ist. Das Verfahren umfasst den Empfang des dreidimensionalen digitalen Präparationsmodells des präparierten Zahns. Ein oder mehrere zu schließende Löcher des dreidimensionalen digitalen Präparationsmodells werden innerhalb des unteren Abschnitts erfasst. Es wird ein Präparationswinkel für die Präparation des unteren Abschnitts bestimmt und das oder die erfassten Löcher werden geschlossen. Das Schließen umfasst eine Extrapolation des unteren Abschnitts in die Löcher unter Verwendung des ermittelten Präparationswinkels.

MULTIFUNCTIONAL HEALTH AND ACTIVITY TRACKER FOR WEARABLE, UNDER-MATTRESS, AND TACTICAL USE

Resumen de: WO2025255553A1

A physiological monitoring device, the device having a housing formed by two rigid structural elements, a soft elastomeric part mechanically locked between the two rigid elements, an electromechanical film sensor assembly positioned beneath the soft part, and a conductive electrode that is arranged above the electromechanical film. The electrode includes electrical connection routed to the printed circuit board (PCB), and the device includes electronics for signal processing, wireless communication, and power management.

EXPANDABLE SPINAL IMPLANT SYSTEM AND METHOD OF USING SAME

Resumen de: US2025375304A1

An expandable spinal implant includes a plug movably disposed in a distal aperture and an interior portion of a frame. The plug may be configured for movement from a first position to a second position. The plug may include a plug proximal end, an opposite plug distal end, a body portion, and a head portion extending from the body portion to the plug distal end. Movement of the plug from the first position to the second position, and corresponding interaction of a head portion with a first endplate portion may causes the first endplate portion and a first distal end portion to move away from the frame and interaction of the head portion with a second endplate portion may cause the second endplate portion and a second distal end portion to move away from the frame to move the implant from a collapsed position to an expanded position.

Structured solid dosage form

Resumen de: US2025375383A1

At present, the most prevalent pharmaceutical dosage forms, the oral immediate-release tablets and capsules, are porous solids of compacted drug and excipient powders. Upon ingestion, physiological fluid percolates the open pores, and the dosage form disintegrates and the drug dissolves. Because the pores in the compacted solids are not well connected, however, fluid percolation generally is not uniform, and the drug release rate is difficult to predict and control. To overcome such limitations, therefore, herein a structured solid dosage form is disclosed. The structured solid dosage form comprises a structural assembly of one or more repeatably arranged, extruded structural elements. The elements comprise segments separated and spaced from adjoining segments by free spacings defining one or more substantially interconnected free spaces, or channels, in the dosage form through which a physiological fluid may percolate. The disclosed dosage form enables more predictable drug release rates, and can be readily manufactured by 3D-printing.

DENTAL APPLIANCES AND ASSOCIATED SYSTEMS AND METHODS

Resumen de: US2025375266A1

The present technology comprises methods of manufacturing an orthodontic appliance. For example, a method can include forming an orthodontic appliance in an intermediate configuration by a casting process. The method can further include securing the appliance to a shape forming fixture such that the appliance assumes a desired configuration. The shape forming fixture can comprise a gingiva portion including a surface having a shape corresponding at least in part to a gingiva of a patient and a securing portion carried by the gingiva portion and configured to releasably secure to a portion of the appliance. The method can further include setting a shape of the appliance while the appliance is secured to the shape forming fixture.

Insertion Aid Apparatus for Diaper Inserts

Resumen de: US2025375324A1

A diaper insert insertion aid apparatus is disclosed, designed to streamline and simplify the process of inserting absorbent inserts into cloth diaper covers. The apparatus comprises a main body configured to hold multiple reusable cloth diaper inserts, a fastening mechanism to secure the inserts in place, and resilient pads for stability. In one embodiment, the main body further includes a handle for ease of manipulation. The apparatus can accommodate inserts with or without pockets, and the pocketed inserts can be further supported by a dedicated structure within the apparatus. This invention aims to address the inconvenience and physical strain associated with traditional manual insertion methods, making cloth diapering more accessible and appealing to a wider range of users, including those with limited dexterity or handling multiple diapers. The apparatus is adaptable to various insert configurations and can also find possible applications in other textile manufacturing processes.

METHOD OF PRODUCING A DENTAL OBJECT

Resumen de: US2025375921A1

A method of producing a dental object, including the steps of printing (S101) a printing layer of the dental object; evaporating (S102) a solvent of the printed printing layer; and detecting (S103) a temperature profile during evaporation of the solvent.

SCAFFOLD BASED IMPLANTS

Resumen de: US2025375287A1

Certain aspects of the present disclosure provide a flexible scaffold implant comprising a plurality of layered structures, the plurality of layered structures comprising: a first layered structure having a three-dimensional (3D) shape and formed from a bioresorbable material, and a second layered structure conforming to the corresponding 3D shape of the first layered structure and formed from the bioresorbable material. The first layered structure is arranged in proximity to the second layered structure. The first layered structure is configured to dissolve for resorption at a different rate than the second layered structure based on design elements of the first layered structure and the second layered structure. The plurality of layered structures are flexible.

METHOD OF PRODUCING A DENTAL OBJECT

Resumen de: US2025375273A1

A method of producing a dental object, including the steps of printing (S101) a substructure; printing (S102) an intermediate layer from a support material on the substructure; and printing (S103) the dental object from the production material for the dental object on the intermediate layer.

METHOD OF PRODUCING A DENTAL OBJECT

Resumen de: US2025375275A1

A method of producing a dental object (100), including the steps of printing (S101) the dental object by means of a production material and a support structure by means of a meltable support material layer by layer; melting (S102) the support material; and absorbing (S103) the molten support material in the production material of the printed dental object.

POLYMER FILAMENT REINFORCED SCAFFOLD FOR PARTIAL MENISCUS REGENERATION

Resumen de: US2025375299A1

A method for fabricating a resorbable scaffold for regeneration of meniscal tissue is disclosed. The method includes fabricating a polymer filament network using 3D printing in accordance with a digital model of the polymer filament network, such that the polymer filament network will include a first plurality of layers comprising the circumferentially-oriented filaments alternating with a second plurality of layers comprising the radially-oriented filaments, the polymer filament network having a three-dimensional shape and geometry between a first layer and a second layer which is substantially the same as a three-dimensional shape and geometry of the resorbable scaffold.

POSTERIOR BITE INTERFERENCE ELEMENTS

Resumen de: US2025375269A1

The present disclosure discusses techniques for fabricating bite interference elements within polymeric dental appliances. The techniques disclose at least one polymeric shell that includes a number of cavities shaped to fit over a patient's teeth. The polymeric shell includes an occlusal appliance surface shaped to fit over an occlusal tooth surface of the patient. One or more bite interference elements are formed within the occlusal appliance surface, and each bite interference element includes a partially disc-shaped feature extending radially away from the occlusal tooth surface when worn by the patient.

Culture Apparatus and Printing Method

Resumen de: US2025376651A1

A culture apparatus includes a bioprinter that linearly prints bioink, a housing configured to accommodate a substrate that supports the bioink, a driver that moves the bioprinter and the housing relatively to each other, and a controller. The controller is configured to control the driver to locate an outlet of the bioprinter at a printing start position in the housing and thereafter to move the outlet in a first direction in the substrate within the housing. The controller is configured to control a pump for the bioink to start application of a pressure to the bioink after the outlet is inserted in the substrate and before the outlet starts moving from the printing start position in the first direction.

DRUG-LOADED FILAMENT COMPRISING TOPIRAMATE AND PHARMACEUTICAL PREPARATION FOR PREVENTING OR TREATING OBESITY PREPARED USING SAME

Resumen de: WO2025254423A1

The present invention relates to a drug-loaded filament comprising topiramate and a pharmaceutical preparation for preventing or treating obesity prepared using same. Topiramate contained in the filament exhibits an amorphous nature, and thus can be used in the preparation of a pharmaceutical preparation that is easily dissolved, thereby facilitating application and absorption in the body. The drug-loaded filament comprising same can be applied to 3D printing such as fused deposition modeling (FDM) and effectively used in the preparation of a pharmaceutical preparation that can be administered via various mucosal administration routes, such as oral mucosa, e.g., sublingual and buccal mucosa, and nasal mucosa in the nasal cavity or the like.

COLLIMATORS FOR ULTRA-HIGH DOSE RATE RADIATION

Resumen de: WO2024163434A1

A collimator assembly for a linear accelerator for use in FLASH radiotherapy includes a collimator and a tray. The collimator includes an elongated body and a base and can also include an opening that defines a central bore formed in the elongated body and the base and extending the length of the collimator along a central axis. The tray includes a central opening having a larger cross-section than the elongated body of the collimator but smaller than the base of the collimator to allow only the elongated body of the collimator to pass therethrough such that the collimator is retained by the tray for reversible installation on the linear accelerator. The tray is adapted to be removably installed on accessory rails of the linear accelerator. Both the collimator and tray may be fabricated by 3D printing to allow for customization.

DEVICES AND METHODS FOR DELIVERING A DRUG VIA AN API-LOADED TISSUE PENETRATOR

Resumen de: CN120603620A

A drug delivery device comprises at least one tissue penetrating member configured to be embedded in tissue, the at least one tissue penetrating member comprising: at least one lumen formed below an outer surface of the at least one tissue penetrating member, the at least one cavity has a depth from the outer surface and a width in a direction orthogonal to a direction of the depth from the outer surface; and at least one opening in the outer surface, the at least one opening in communication with the at least one lumen such that at least one API loaded into the at least one lumen can be absorbed from the at least one lumen into the tissue, where the width of the at least one opening is less than the width of the at least one lumen.

MEDICAL DEVICE FOR 3D PRINTED MEMBERS OR JOINTS AND MAGNET CLOSURE SYSTEM THEREFOR AND METHOD OF MAKING SAME

Resumen de: EP4659719A1

Dispositif médical (100,200,300,400) pour immobiliser un membre ou une articulation, ledit dispositif comportant au moins deux demis-coques complémentaires (10a-b,20a-b,30a-b,40a-b) de forme sensiblement alvéolaire, lesdites demis-coques comprenant chacune au moins deux surfaces de contact (101a-b,102a-b,201a-b,202a-b,203a-b,301a-b,302a-b,303a-b,401a-b,402a-b), un système de fermeture (12,22,32,42), le système de fermeture (12,22,32,42) étant positionné dans des logements (103a-b,204a-b,304a-b,403a-b) des surfaces de contact (101a-b,102a-b,201a-b,202a-b,203a-b,301a-b,302a-b,303a-b,401a-b,402a-b), ledit système de fermeture étant magnétique, ledit système de fermeture étant invisible lorsque le dispositif médical (100,200,300,400) est assemblé.

SYSTEMS AND METHODS FOR IN VIVO CELL REPLACEMENT

Resumen de: US2024252719A1

A method for in-vivo cell replacement is disclosed. The method includes steps of extracting donor cells from a donor tissue of a patient; generating donor material including the donor cells; removing one or more cell layers from a receiver tissue of the patient to expose a target layer of the receiver tissue while maintaining operation of a vasculature of the receiver tissue; and printing the donor material onto the target layer of the receiver tissue. A tissue position assembly, a composition for use in a treatment of bladder damage or bladder dysmorphism, and a system for supplying donor material to a bioprinter are also disclosed.

PROSTHETIC PARTIAL FINGERS

Resumen de: EP4659714A2

There is provided a prosthetic finger, comprising: a knuckle (165) that attaches to a prosthetic socket (194); a first phalange (155) having a phalange end coupled to the knuckle (165) and configured to move in flexion and extension with respect to the knuckle (165); a distal phalange (160) coupled to the first phalange (155) and configured to move in flexion and extension; a link bar (170) extending through the first phalange (155) and having: a first link bar end coupled to the knuckle; and a second link bar end coupled to the distal phalange; and a ratcheting mechanism (157) comprising: a set of teeth (167); and a release lever (175) that moves between a first position and a second position, wherein: in the first position, the release lever is engaged with the set of teeth and prevents movement of the first phalange and the distal phalange in extension; and in the second position, the release lever is disengaged with the set of teeth and allows movement of the first phalange and the distal phalange in extension.

DEVICES AND METHODS FOR DELIVERING A DRUG VIA AN API-LOADED TISSUE PENETRATOR

Resumen de: CN120712122A

A drug delivery device includes a substrate; and a plurality of tissue penetrating members 3D printed onto the substrate and configured to be embedded into tissue, wherein at least one tissue penetrating member of the plurality of tissue penetrating members is configured to anchor the drug delivery device to the tissue; and at least one payload comprising at least one API loaded into at least one of the substrate and the plurality of tissue penetrating members for absorption into the tissue when the at least one tissue penetrating member is embedded in the tissue.

DEVICES AND METHODS FOR DELIVERING A DRUG VIA AN API-LOADED TISSUE PENETRATOR

Resumen de: CN120641167A

A drug delivery device comprises at least one tissue penetrating member configured to be embedded in tissue, the at least one tissue penetrating member comprising: a plurality of lumens, and at least one payload comprising at least one active pharmaceutical ingredient (API) loaded into the plurality of lumens, the at least one tissue penetrating member is configured such that when the at least one tissue penetrating member is embedded in the tissue, the at least one API can be absorbed into the tissue wherein a ratio of a surface area of the plurality of lumens to a volume of the plurality of lumens is at least 0.5: 1.

AN APPARATUS AND METHOD FOR A TRANSALVEOLAR DENTAL IMPLANT

Resumen de: EP4659703A2

The present disclosure relates to single tooth or full arch dental restoration. In cases where patients have insufficient bone stock for conventional root-form dental implants, current solutions often fail to restore function. The present disclosure describes a transalveolar dental implant for single tooth or full arch dental restoration. The transalveolar dental implant is comprised of a post and a bone plate, the bone plate having a contoured portion fabricated to match the topography of a bony surface of the facial skeleton. Through primary fixation of the contoured portion of the bone plate, the transalveolar dental implant improves function and outcomes in affected patients.

AUTOMATED MANAGEMENT OF CLINICAL MODIFICATIONS TO TREATMENT PLANS USING THREE-DIMENSIONAL CONTROLS

Resumen de: EP4661024A2

Methods and apparatuses, including systems, for forming and modifying treatment plans, including modifying treatment plan in real time. In particular are methods and apparatuses for modifying and orthodontic treatment plan in real time that may include the use of an enhanced user interface including a 3D user overlay.

METHODS OF DESIGNING AND MAKING CUSTOMIZED DENTAL CARE SYSTEMS

Resumen de: WO2024163970A2

The various embodiments described herein include methods, devices, and systems for customizing dental care. In one aspect, personalized toothbrush devices are 3-D printed for a plurality of users. A 3-D dental model of a respective user's mouth is obtained, and a configuration for a mouthpiece of a respective personalized toothbrush device is determined. The respective personalized toothbrush device is 3-D printed, and includes a top cleaning tray, a bottom cleaning tray, and a set of cleaning elements, each customized based at least in part on the 3-D dental model of the respective user's mouth. Each personalized toothbrush device is 3- D printed for each respective user of the plurality of users, and is different from every other user's personalized toothbrush device.

一种基于数字化建模的可快速脱拆义齿系统及其制作方法

Resumen de: CN121095468A

本申请涉及口腔种植引导技术领域，提供了一种基于数字化建模的可快速脱拆义齿系统及其制作方法。该方法包括：通过口腔扫描仪获取患者口腔内三维数据，通过神经辐射场模型对患者口腔内结构进行三维重建；在三维口腔模型中设置虚拟替代体，构建可拆义齿的虚拟实体；从三维口腔模型中提取可拆义齿参数及虚拟实体与虚拟替代体之间的初始位置关系；结合初始位置关系及与口腔就诊相关的患者个体化数据，采用位移预测模型预测可拆义齿在咬合过程中符合长期使用状态的位移变化趋势获得修正策略；采用修正策略优化可拆义齿参数及对应的初始位置关系，由用户端确认后通过义齿制造端生产匹配的可拆义齿定制化模型，提升可拆义齿与患者口腔的适配度。

一种用于创面修复的声波辅助3D打印复层高密度细胞贴片及其制备方法

Resumen de: CN121081750A

本发明公开了一种用于创面修复的声波辅助3D打印复层高密度细胞贴片及其制备方法，该方法将定制的声波平台、信号发生器、功率放大器和3D打印机结合，信号发生器产生的正弦波通过功率放大器被放大，经过声波平台上的指间交叉换能器将电信号转变为声波信号，信号通过具有正逆压电效应的基板在生物墨水中产生机械能，将细胞聚集在打印平台中心，从而生物打印形成复层高密度细胞贴片；通过更换不同细胞种类的生物墨水，改变打印参数逐层打印三种细胞，制备得到复层高密度细胞贴片。本发明制备的复层高密度细胞贴片特征在于具有仿人体皮肤的三层结构和人体内细胞的高密度，具有诱导细胞迁移、促进血管生成，改善炎症反应，从而加速创面愈合的优点。

聚乳酸/丝蛋白3D打印气管支架的制备方法

Resumen de: CN121081744A

本申请提供了一种聚乳酸/丝蛋白3D打印气管支架的制备方法，属于医疗器械技术领域。本申请将聚乳酸和热塑性淀粉按特定比例混合，造粒，接着熔融挤出、牵伸，得到复合线材，再经熔融沉积3D打印，并依次于聚乙二醇（PEG）和丝素蛋白水溶液中浸泡，得到聚乳酸/丝蛋白气管支架。相比常规PLA线材成分简单可控。通过引入热塑性淀粉对PLA的熔融指数和结晶速率进行调控，改善其可打印性和打印样品的稳定性。用PEG进行浸泡，PEG分子可渗入气管支架，使支架发生轻微溶胀软化，提高支架的亲水性。将丝蛋白涂敷在支架表面，提高支架生物相容性。采用熔融沉积3D打印工艺，比直写式3D打印工艺更加稳定，更利于制备性能均一稳定的气管支架。

一种3D打印颌骨囊肿塞治装置及其制作方法

Resumen de: CN121081154A

本发明属于医疗器械技术领域，公开了一种3D打印颌骨囊肿塞治装置及其制作方法，该装置包括术中定位导板和术后囊肿塞治器。其制作方法包括：获取患者颌骨三维影像数据和牙列三维扫描数据；在计算机中对数据进行重建、分割和精确配准，生成融合数字化模型；基于该模型个性化设计导板和塞治器；最后通过3D打印机制造出实体装置。本发明采用全数字化工作流程，能够在术前一次性完成导板和塞治器的精确设计与制作，省去了传统术后取模的繁琐步骤，提高了制作效率和装置的适配精度，使手术更精准、微创，同时提升了患者的佩戴舒适度和治疗效果。

结构功能一体化仿生椎间融合器制备方法与装置

Resumen de: CN121081171A

本发明涉及生物医学新材料技术领域，提供一种结构功能一体化仿生椎间融合器制备方法和装置，借计算机辅助设计与拓扑优化算法确定支架的初始多孔结构骨架。选用可降解金属材料粉末作支架材料，制成三维多孔结构的支架坯件，选生物玻璃等作涂层靶材，激光作用下形成均匀可控的熔融玻璃液滴，气流带动液滴定向输送至多孔支架，穿透外部孔隙沉积于内部孔隙表面。多孔支架旋转与气流协同实现三维多向表面涂敷，最终得到支架融合器。本发明还公开了一种用于上述方法的装置。该方法和装置能够在复杂结构处理与性能调控领域，能突破传统线扫描或渗透式涂层方法难以在复杂拓扑结构内部实现均匀涂覆的瓶颈，适用于不同宏观拓扑结构和孔隙尺寸的多孔支架。

矫治器制作用压膜模型及其制作方法、矫治器的制作方法

Resumen de: CN116687591A

The invention provides a pressed film model for manufacturing an appliance, the pressed film model comprises a tooth jaw prototype and an accessory model on the tooth jaw prototype, the accessory model comprises a connecting part and an accessory part, a gap is formed between the accessory part and the tooth jaw prototype, the connecting part is located in the gap and used for connecting the accessory part and the tooth jaw prototype, and the connecting part is located in the gap and used for connecting the accessory part and the tooth jaw prototype. When force larger than a preset value is applied to the connecting part, the connecting part is broken, and therefore the accessory part is separated from the tooth jaw prototype. Through the arrangement of the breakable connecting part in the pressed film model, the demolding difficulty of the appliance can be reduced, and the appliance is prevented from deforming or cracking in the demolding process. Meanwhile, the invention further provides a manufacturing method of the pressed film model for manufacturing the appliance and a manufacturing method of the appliance.

一种功能性可降解大豆油基仿生多孔复合骨支架的制备方法和应用

Resumen de: CN121081747A

本发明公开了一种功能性可降解大豆油基仿生多孔复合骨支架的制备方法和应用。该方法以环氧大豆油丙烯酸酯为生物基基材，复配甲基丙烯酸异冰片酯以改善其高粘度、低光敏性缺陷，加入光引发剂包含2,4,6‑三甲基苯甲酰基苯基膦酸乙酯与苯基双（2,4,6‑三甲基苯甲酰基）氧化膦复配后经老化处理得到基料树脂；再将木质素磺酸钙掺入基料树脂中制得复合光敏树脂，通过数字光处理技术3D打印技术打印三重周期极小曲面结构，最终得到功能性可降解豆油基仿生多孔支架。该支架兼具木质素磺酸钙介导在模拟人体内环境的条件下表现出近红外光光照调控与骨支架组分依赖的可控的光热响应行为，从而实现可控的光热响应介导的远程形状记忆功能的同时还可以实现温和的、安全可控的光热疗效。此外，木质素磺酸钙在改善支架亲水性能的同时，通过优先溶解并使得基体表面产生微孔结构而促进复合支架降解，并持续释放钙离子，由此使支架表现出增强的生物矿化能力并促进了细胞增殖和成骨分化。本研究为大豆油基生物光敏材料在仿生多孔骨支架的数字光处理制备技术以及多功能化应用中提供了一种具有潜力的解决方案以应对复杂不规则的骨缺损。

基于大分子拥挤效应的重组Ⅲ型人源化胶原蛋白凝胶及其制备方法与应用

Resumen de: CN121081743A

本发明提供了一种基于大分子拥挤效应的重组Ⅲ型人源化胶原蛋白凝胶及其制备方法与应用。首先配制rhCol III溶液体系；随后配制包含右旋糖酐70、聚乙二醇8000及抗坏血酸的大分子拥挤浴；再将rhCol III溶液加入上述大分子拥挤浴中以形成rhCol III微凝胶；最后构建以琼脂糖为基底、含功能添加剂以及温敏聚合物作为温敏释放与空间约束组件的3D打印分子排阻模具系统，实现rhCol III微凝胶的定向构建。本发明实现rhCol秒级物理成胶（<15 s），并构建了支持细胞增殖的生理微环境。本发明制得的重组Ⅲ型人源化胶原蛋白凝胶可用于制备胶原微凝胶球，胶原束，3D生物打印等产品，应用范围广泛。

Formulation pharmaceutique imprimable par extrusion, cartouche d’impression renfermant une telle formulation et procédé de préparation d’un médicament la mettant en œuvre

Resumen de: FR3162625A1

L’invention est relative à une formulation pharmaceutique adaptée à la fabrication de doses unitaires d’un médicament solide ou semi-solide par impression 3D, à une cartouche d’impression renfermant une telle formulation pharmaceutique à l’utilisation de cette formulation pharmaceutique pour la fabrication de doses unitaires d’un médicament solide ou semi-solide par impression 3D, à une cartouche d’impression renfermant une telle formulation pharmaceutique, et à un procédé de préparation d’un médicament sous la forme de doses unitaires par impression 3D mettant en œuvre une telle formulation. Figure à publier avec l’abrégé : 1

歯科補綴部品の製造方法、アダプタ、ブランク、アダプタとブランクのセット、および複数のアダプタのセット

Resumen de: CN119947675A

The invention relates to a method for producing a tooth substitute part (200) that can be connected to a tooth stump (110), in particular a stationary tooth substitute part (200), wherein an adapter (10) for a machine tool and a blank (50) for a tooth substitute part (200) are produced.

用于生产三维丝网印刷工件的设备

Resumen de: WO2024188675A1

The invention relates to an apparatus for producing three-dimensional screen-printed workpieces, in particular a 3D screen printing installation, said apparatus comprising: a printing device for the layer-by-layer production of at least one screen-printed workpiece in a plurality of printing operations; and a drying device which is designed to dry at least one screen-printed workpiece and to simultaneously cool a workpiece carrier that carries the screen-printed workpiece to be dried.

用于生产三维丝网印刷工件的工件载体和装置

Resumen de: WO2024188677A1

The invention relates to a workpiece carrier, in particular for producing three-dimensional screen-printed workpieces, said workpiece carrier comprising: at least one printing bed which has a printing surface to be printed; and a support structure which supports the printing bed and is formed separately from the printing bed, the support structure having a support base and at least one stop for the printing bed, the printing bed being arranged on the support base, and it being possible to bring the printing bed, when in the position arranged on the support base, into contact with the stop in at least one lateral direction.

一种用于假牙精准定位的数字化辅助定位装置及方法

Resumen de: CN121074143A

本申请涉及口腔种植引导技术领域，提供了一种用于假牙精准定位的数字化辅助定位装置及方法。该方法包括：获取患者口腔的骨结构数据、软组织数据、以及患者生理数据，形成口腔内部结构数据；通过分割模型对口腔内部结构数据进行分割处理，得到患者口腔内部的牙龈牙齿边界特征模型；基于口腔内部结构数据通过多模态时序预测网络中与患者代谢状态匹配的预测子模型，预测患者在未来预设时长内符合患者代谢状态变化情况的定位偏移量；基于定位偏移量，优化牙龈牙齿边界特征模型中假牙与周围口腔环境之间的空间关系，并基于牙龈牙齿边界特征模型输出假牙定位辅助信息，用以作为口腔模型打印机制作假牙模型的定位参考，提升定位准确性以及长期稳定性。

一种基于多材料3D打印构建的医用钳子及其制备方法

Resumen de: CN121059246A

本发明公开了一种基于多材料3D打印构建的医用钳子及其制备方法。包括以下步骤：基于患者医学影像数据或标准器械模型，通过计算机辅助设计软件进行个性化设计，构建一体化三维数字模型；接着进行拓扑优化，在非关键受力区域设计减重结构，并使用切片软件处理生成多材料打印指令文件；然后采用多材料3D打印设备，根据预先设定的材料分配方案，使用具有不同力学性能的材料在所述钳喙、活动关节和钳柄区域同步进行一体化打印，制造出钳子生坯；最后进行清洗、关键部位表面精加工及灭菌处理，得到最终产品。本发明能够根据特殊手术需求，快速设计和制造匹配的钳子，在同一器械上集成多种性能各异的材料，提升手术精准度和效果。

一种基于光聚合3D打印中药防臭矫形鞋垫的制备方法

Resumen de: CN121062211A

本发明公开了一种基于光聚合3D打印中药防臭矫形鞋垫的制备方法，属于足部护理及鞋垫技术领域，为了解决现有中药成分在鞋垫中的分布均匀性欠佳，且容易出现脱落现象，致使防臭性能大打折扣的问题；本发明将粉碎后的中药与光敏树脂混合，并添加分散剂借助其表面活性降低中药颗粒团聚力，确保中药颗粒在光敏树脂中均匀分散，同时，针对足部不同区域的压力特征，通过设置中药层厚度，如前脚掌0.3‑0.5cm、足弓0.2‑0.4cm、足跟0.4‑0.6cm，并结合逐层固化的3D打印特性，保证高压力区域的中药含量充足，提升防臭效果的针对性与持久性，表层采用竹纤维与棉纤维混纺面料，不仅利用竹纤维的高吸湿性快速吸收足部汗液，其天然抗菌性还与中药层形成协同防臭机制，增强防臭性能。

新型方法

Resumen de: WO2024201321A1

The present invention relates to a process for obtaining a dental prosthesis comprising a crown and tooth root. Said process comprises at least one step of directing undifferentiated cells or keratinocytes and at least one three-dimensional printing step, preferably 3D bioprinting of the dental prosthesis. Furthermore, the invention regards the dental prosthesis obtained with the process and a bioink suitable for three-dimensional printing (3D), preferably suitable for 3D bioprinting.

基于动态厚度补偿的透明矫治器动态厚度补偿生产工艺方法

Resumen de: CN121062188A

本发明公开了基于动态厚度补偿的透明矫治器动态厚度补偿生产工艺方法，属于口腔正畸医疗器械制造技术领域，包括以下步骤：S1，获取序列矫治模型；S2，CAE厚度预测；S3，动态调整决策；S4，自适应制造执行：根据步骤S3选用以下任一制造路径生产矫治器：S4（a），梯度成品膜片热成型路径；S4（b），3D打印增材制造路径，该发明具备能确保矫治器的成型厚度一致，且能结合三维动态仿真以及3D打印等多样化生产工艺的优点，解决了现有矫治器的成型厚度不一致、生产工艺较为单一、缺乏三维动态仿真，进而影响矫治器的生物力学表现，并严重制约个性化正畸方案落地实施的问题。

一种基于三维扫描的数字化假牙安装定位装置及其方法

Resumen de: CN121074284A

本申请涉及口腔种植引导技术领域，提供了一种基于三维扫描的数字化假牙安装定位装置及其方法。该方法包括：通过口腔扫描仪扫描患者口腔生成三维口腔数字化模型；通过SegFormer分割网络，基于三维口腔数字化模型生成患者的虚拟种植体以及对应的初始植入参数；基于历史手术数据、初始植入参数、骨质密度、患者属性以及咬合力参数，采用长序列预测网络通过分段注意力机制以及网络记忆缓存机制预测虚拟种植体在骨结合后的位置偏移量及骨吸收程度获得最佳植入参数；基于最佳植入参数向用户推送包含候选定位策略的可视化动态模型，驱动口腔模型打印机得到种植导板模型和口腔环境模型，辅助用户验证候选定位策略的安装效果，提升假牙安装定位准确性。

定制耳部设备的自动设计

Resumen de: WO2024200441A1

Described herein is a computer-implemented method for constructing in the form of designing in a virtual environment a custom ear device in an automated process utilizing a trained neural network. The computer-implemented method described is configured to allow for changing the output form the neural network to create change to an automatic generated custom ear device design. Furthermore, described herein is a system utilizing a processor running the method described herein to automatically generate virtually constructed custom ear devices that may be modified to adjust for any incorrect outputs generated by a neural network.

可聚合的聚氨酯和含有该聚氨酯的组合物，用于3D打印牙科材料

Resumen de: US2024352179A1

The present disclosure provides curable compositions comprising one or more of photo-polymerizable urethane prepolymers having alternating hard and soft blocks, as well as polymeric materials formed from the curable compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

一种盆腔术后充填材料及其制备方法和应用

Resumen de: CN121059903A

本发明属于生物医用材料技术领域，提供了一种盆腔术后充填材料及其制备方法和应用。本发明的盆腔术后充填材料包含凝胶化生物膜基质和纳米弹性材料，限定了原料的质量比。本发明采用凝胶化生物膜基质，保留细胞外基质原有的三维结构、胶原纤维、非胶原蛋白及生长因子等成分，具有优异的生物相容性；采用物理交联法将凝胶化生物膜基质与纳米弹性材料交联，无需化学交联剂，无副作用；通过静电动态液体纺丝制备纳米弹性材料，促进充填材料与宿主细胞的相互融合，提高修复效果；采用天然聚合物和合成聚合物制备纳米弹性材料，赋予良好的生物相容性、稳定的支撑作用以及良好的拉伸应变，防止脏器脱垂，加快术后修复。

复合牙颌模型及其数字模型设计方法、牙科器械制作方法

Resumen de: CN121059320A

本发明公开一种复合牙颌模型，包括：上颌牙颌模型、下颌牙颌模型和能够锁定上下颌相对位置关系的定位组件；上颌牙颌模型包括上颌牙齿部和支撑上颌牙齿部的上颌支撑部；下颌牙颌模型包括下颌牙齿部和支撑下颌牙齿部的下颌支撑部；定位组件包括与上颌支撑部连接的上颌定位件和与下颌支撑部连接的下颌定位件；其中，上颌定位件和下颌定位件直接装配或间接装配后，能够将复合牙颌模型的上下颌相对位置定位至患者目标颌位的对应位置。本发明还提供了复合牙颌数字模型的设计方法，以及牙科器械的制作方法。

一种胫骨近端截骨器具

Resumen de: CN223627552U

本申请涉及医疗器械的技术领域，尤其是涉及一种胫骨近端截骨器具，其包括截骨导板，所述截骨导板包括导板主体和护套，所述护套设于所述导板主体的周向，所述导板主体和所述护套共同覆盖患部胫骨近端端面；克氏针固定孔，设置在导板主体上，用于引导克氏针钉入患者胫骨以固定所述导板主体；髓针定位孔，设置在导板主体上，用于定位假体髓针的位置；刀槽，设置在所述护套上，用于引导截骨工具进行截骨。本申请具有将髓针的定位与截骨两个步骤合二为一，节省手术时间，减少感染概率的效果。

PASTE WITH AN API AND A PERMEATION ENHANCER FOR 3D-PRINTING

Resumen de: WO2025247506A1

The present disclosure generally relates to a paste for carrying an active pharmaceutical ingredient (API), preferably a GLP-1 agonist and a permeation enhancer, preferably a fatty acid and/or a pharmaceutical acceptable salt thereof, such as sodium decanoate, preferably for use in a screen printing process for printing a pharmaceutical composition. The present disclosure further relates to a method for preparing a paste, and the use of a paste in an additive manufacturing process.

IMPLANT FOR CORRECTING A DEFECT OF A BONE STRUCTURE WITH NAVIGATION FIDUCIALS

Resumen de: JP2024057092A

To provide a system for manufacturing and using an implant for correcting a defect of a bone structure.SOLUTION: The implant includes a first surface comprising a shape configured to interface with a surface of the bone structure. In some examples, the implant includes a second surface opposite the first surface and substantially conformal to the shape of the first surface, the second surface comprising three or more point features on the second surface, wherein the three or more point features comprise a first point feature, a second point feature, and a third point feature that form nodes of a triangle, and each of the three or more point features is recessed below the second surface.SELECTED DRAWING: Figure 5D

ADDITIVE MANUFACTURING SYSTEM, METHOD AND CORRESPONDING COMPONENTS FOR MAKING ELASTOMERIC STRUCTURES

Resumen de: US2025367876A1

A system for additive manufacturing a medical device, the system comprising a first dispensing system, a second dispensing system, a deposition apparatus, and a deposition substrate on a surface of which the deposition apparatus is configured to deposit at least one elastomeric material into a filament. The deposition apparatus receives the at least one elastomeric material from the first and second dispensing systems in proportions effecting a desired property in the medical device. The deposition apparatus may comprise heating and/or cooling elements, a sonic vibration module, and/or a pneumatic suck-back valve. The deposition substrate may have a configuration corresponding to a desired shape of the medical device and is configured to rotate and/or translate relative to the deposition apparatus. The system comprises a controller configured to control the deposition.

Microneedles and Methods of Manufacture Thereof

Resumen de: US2025367422A1

A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.

3D PRINTING OF 3-LAYERED RETINA AND CHOROID TISSUE

Resumen de: US2025367348A1

A method for reinforcing a cellularized retinal construct fabricated from (i) endothelial cells; (ii) retinal pigment epithelial cells and/or photoreceptors; and (iii) an extracellular matrix (ECM) hydrogel is disclosed. The method comprises contacting the construct with a biocompatible small-molecule reinforcing agent that is capable of chemically interacting with the ECM hydrogel under conditions that maintain viability of the cells, to thereby increase a compressive modulus of the ECM hydrogel by at least 10%.

SEMI-RADIOLUCENT PATIENT-SPECIFIC 3D-PRINTED LATTICE TITANIUM PLATE

Resumen de: US2025366922A1

A plate for fixating bone, the plate comprising: a plurality of ribs defining a plurality of openings, wherein a first portion of the plurality of ribs define a lattice structure and a second portion of the plurality of ribs define at least four mounting holes. Another aspect of the present disclosure relates to a method for tailoring a plate for fixating bone. The method can include determining an initial design of the plate. The method can include analyzing radiation through the initial design. The method can include determining, based on analyzed radiation, if dosimetric characteristics are desirable. The method can include analyzing structural strength of the initial design. The method can include determining, based on the analyzed structural strength, if structural strength is sufficient.

Validation for Rapid Prototyping Parts in Dentistry

Resumen de: US2025366958A1

Systems and techniques for training one or more neural networks to automatically determine placement of a digital representation of an orthodontic appliance are disclosed including comparing one or more aspects of the second representation of a 3D printed part with one or more respective aspects of a first representation of the 3D printed part, generating a reconstruction error based on the comparing, and when the reconstruction error is greater than a predetermined threshold, assigning one or more result labels that specify that the respective aspects of the 3D printed part were not correctly fabricated and when the reconstruction error is less than the predetermined threshold, assigning one or more result labels that specify that the respective aspects of the 3D printed part were correctly fabricated.

MEDICAL DEVICE BASED ON BIOCERAMICS, ITS USE AS A SYNTHETIC BONE GRAFT AND PROCESS FOR THE PREPARATION THEREOF

Resumen de: US2025366995A1

The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.

ORTHODONTIC SYSTEMS WITH VARIABLE ATTACHMENT AND WELL GEOMETRIES

Resumen de: US2025366953A1

Systems for orthodontic treatment are provided. In some embodiments, a system includes an attachment configured to be coupled to a tooth of a patient. The attachment can include a first surface configured to contact the tooth, a second surface opposing the first surface, and one or more sidewalls connecting the first surface and the second surface. The first surface, the second surface, and the one or more sidewalls can form a solid enclosed volume having a protruding shape. The system can further include an orthodontic appliance including a shell having a plurality of teeth-receiving cavities shaped to reposition the patient's teeth from a first arrangement toward a second arrangement, and an attachment-receiving well formed in the shell. The attachment-receiving well can engage the attachment to effect a movement of at least one tooth of the patient. The attachment can have a different geometry than the attachment-receiving well.

DEVICES AND METHODS OF MAKING AND USE THEREOF

Resumen de: US2025366979A1

Disclosed herein are devices and methods of making and use thereof.

DEVICES AND METHODS OF MAKING AND USE THEREOF

Resumen de: US2025366978A1

Disclosed herein are devices and methods of making and use thereof.

METHOD FOR PRODUCING COMPOSITION FOR REGENERATING CARTILAGE USING LYOPHILIZATION HYALINE CARTILAGE POWDER, COMPOSITION FOR REGENERATING CARTILAGE PRODUCED USING THE SAME, METHOD FOR PRODUCING SCAFFOLD FOR REGENERATING PATIENT-CUSTOMIZED CARTILAGE USING COMPOSITION FOR REGENERATING CARTILAGE, AND SCAFFOLD FOR REGENERATING PATIENT-CUSTOMIZED CARTILAGE

Resumen de: US2025366997A1

The present invention relates to a method for using a lyophilization hyaline cartilage powder to produce a composition for regenerating cartilage, and a composition for regenerating cartilage produced by using the method, the method comprising: A) a step for preparing hyaline cartilage; B) a step for freeze-drying and crushing the hyaline cartilage, and producing a lyophilization hyaline cartilage powder; C) a step for producing an adipose tissue extract from autologous adipose tissue; and D) a step for producing a composition which is for regenerating cartilage and including the lyophilization hyaline cartilage powder and the adipose tissue extract.

Bone insert augment and offset device

Resumen de: US2025366893A1

A bone insert includes a cap having a convex top surface, an elongated stem, and a barrier between the cap and the stem. The stem of the bone insert is inserted into a hole formed in a host bone until the barrier is pressed against the exposed bone. The bone implant can be placed against a small focus contact point on the cap. Liquid cement can be injected into a space volume between the host bone and a bone implant. The cap can be made of a material and/or have surface features that create a strong bond with the cement when the liquid cement cures. The stem can be made of a material and/or have bone ingrowth surface features that create a strong bond with the bone.

FUNCTIONAL GRADIENT LATTICE IN ORTHOPEDIC FIXATION IMPLANT

Resumen de: US2025366894A1

A three-dimensional (“3D”) printed orthopedic fixation implant can reduce stress shielding and/or enhance osseointegration. The implant can include: a head defining a proximal end of the implant; a tip defining a distal end of the implant; a core extending from the head to the tip, the core being elongate; and threads extending along at least a portion of the core. One or more functionally graded lattice structures can be propagated longitudinally and/or radially in at least portions of the core. A density of the one or more functionally graded lattice structures can have a varying longitudinal gradient and a varying radial gradient.

PHOTODETECTORS FOR MEASURING REAL-TIME OPTICAL IRRADIANCE

Resumen de: US2025369798A1

A skin-wearable photodetector module includes an array with a plurality of photodetectors and a plurality of optical filters, and each photodetector is configured to receive an optical input from an optical filter having a central wavelength in a wavelength range of about 100 nm to about 1000 nm. Each photodetector includes a substrate with a first major surface having an electrode thereon, and a second major surface overlying an optical filter, an anode within an interior region of the electrode, an active layer including a. ternary mixture of an electron donor, an electron acceptor, and at least one charge carrier trap material, and a cathode that contacts the active layer.

ARTICLES AND METHODS FOR FORMAT INDEPENDENT DETECTION OF HIDDEN CARDIOVASCULAR DISEASE FROM PRINTED ELECTROCARDIOGRAPHIC IMAGES USING DEEP LEARNING

Resumen de: US2025372251A1

Provided herein are computer-implemented methods of detecting cardiovascular disease in a subject. The methods include receiving an electrocardiogram (ECG) image for the subject; applying a machine-learning based algorithm to the ECG image for the subject, the algorithm being trained to distinguish a printed ECG reading of a heart with cardiovascular disease from a printed ECG reading of a healthy heart; comparing outputs of the algorithm to patterns of algorithm outputs for ECG images from healthy subjects and subjects with one or more cardiovascular diseases; and determining if the subject has cardiovascular disease based upon the outputs of the algorithm.

PHOTOCURABLE COMPOSITION FOR STEREOLITHOGRAPHY, THREE-DIMENSIONAL ARTICLE, AND INSTRUMENT USED IN ORAL CAVITY

Resumen de: WO2025249198A1

This photocurable composition for stereolithography comprising: a di(meth)acrylic monomer (A) containing two (meth)acryloyloxy groups; a mono(meth)acrylic monomer (B) containing one (meth)acryloyloxy group and at least one group selected from the group consisting of groups (b1) to (b13); and a photopolymerization initiator. * indicates the bonding position. Any one of Rb1A to Rb1G is a divalent group, and the rest are H or a monovalent group. One of Rb2A and Rb2B is a divalent group, the other is H or a monovalent group, and each of Rb2C and Rb2D is H or a monovalent group. Any one of Rb3A to Rb3I is a divalent group, and the rest are H or a monovalent group. In the group (b5), each of Rb5A to Rb5H is H or a monovalent group.

OSSEOINDUCTIVE BONE GRAFT PREPARATION FROM HUMAN HARD TISSUES AND METHODS FOR CUSTOMIZABLE BONE REGENERATION

Resumen de: WO2025248557A1

This invention relates to the preparation of bone grafts from human hard tissues, such as teeth, bone, and cartilage, that retain osseoinductive potential. The grafts are processed through optimized lab procedures to preserve their biological activity, achieve sterilization, and minimize water content for enhanced shelf life. These grafts can be formulated into particulate, block, or dough/pastel - like forms. The particulate matter can be combined with body fluids containing growth factors to create a moldable material for packing into bone defects, promoting superior osteogenesis. Additionally, the particulate matter can be used in 3D printing to produce customized grafts with controlled porosity based on CT scans and computer-aided design (CAD). Block grafts can be machined into precise shapes using CAD models and computer-aided machining (CAM).

EXTRUSION-PRINTABLE PHARMACEUTICAL FORMULATION, PRINT CARTRIDGE CONTAINING SUCH A FORMULATION AND METHOD FOR PREPARING A MEDICAMENT USING SAME

Resumen de: WO2025247979A1

The invention relates to a pharmaceutical formulation suitable for the manufacture of unit doses of a solid or semi-solid medicament by 3D printing, to a printing cartridge containing such a pharmaceutical formulation, and to the use of this pharmaceutical formulation for the manufacture of unit doses of a solid or semi-solid medicament by 3D printing, to a printing cartridge containing such a pharmaceutical formulation, and to a method for preparing a medicament in the form of unit doses by 3D printing using such a formulation.

METHOD FOR MANUFACTURING A MEDICAL BONE CONNECTING DEVICE

Resumen de: WO2025247746A1

A method for manufacturing a medical bone connecting device (10) is proposed that serves to connect two bones (V, H) or bone parts of a human or animal patient. The method comprises at least the following steps: a.) targeted deposition (80) in a common layer (17) of one or more strands (13) of reinforcing fibers (11) embedded in a matrix material (12), b.) repetition (81) of step a.) for a plurality of successive layers (17), in order to produce a preform (18) of the bone connecting device (10), and c.) compression (82) of the preform (18) in a mold (70) to form the bone connecting device (10). The strand or strands (13) are deposited in such a way in step a.) that they follow a multiple curved path (15) without crossing themselves or each other. Furthermore, a bone connecting device (10) manufactured according to this method is disclosed.

FUNCTIONAL GRADIENT LATTICE IN ORTHOPEDIC FIXATION IMPLANT

Resumen de: WO2025250670A1

A three-dimensional ("3D") printed orthopedic fixation implant can reduce stress shielding and/or enhance osseointegration. The implant can include: a head defining a proximal end of the implant; a tip defining a distal end of the implant; a core extending from the head to the tip, the core being elongate; and threads extending along at least a portion of the core. One or more functionally graded lattice structures can be propagated longitudinally and/or radially in at least portions of the core. A density of the one or more functionally graded lattice structures can have a varying longitudinal gradient and a varying radial gradient.

歯科用コンポーネントの製造のための放射線硬化性組成物

Resumen de: US2025361406A1

The invention relates to a radiation-curing composition for the manufacture of dental components using the DLP process or SLA process, comprising, based on the total mass of the radiation-curing composition (i) one or more radically polymerizable monomers in a combined mass fraction of 60% or more, (ii) one or more hexaarylbiimidazole compounds in a combined mass fraction in the range of 0.1 to 5%, and (iii) one or more mercaptotetrazole compounds in a combined mass fraction in the range of 0.1 to 5%, wherein the combined mass fraction of fillers in the radiation-curing composition is less than 30%.

METHOD OF MANUFACTURING A SEAT UNIT FOR A WHEELCHAIR, AND A SEAT UNIT

Resumen de: WO2025250016A1

Herein is disclosed a method of manufacturing a seat unit for a wheelchair, and a seat unit for a wheelchair The method comprises the steps of determining a user's needs for support and pressure relief, and thereafter selecting a basic seat cushion module (1) and a basic backrest module (2) before 3D-printing a seat unit adaptation module (4; 5) using information about the determined support and pressure relief needs of the user, for adapting the basic seat cushion module (1) and/or the basic backrest module (2) to the user. The adaptation module (4; 5) is printed with an open 3D structure (3).

BLOCK COPOLYMERS SUITABLE AS IMPACT MODIFIERS, PROCESS FOR THEIR PREPARATION AND POLYMERIZABLE MATERIALS COMPRISING THEM

Resumen de: EP4656661A1

Block copolymer according to Formula 1 and methods for producing the same,wherein n is a value of from 5 to 250; W1 is a group according to Formula 2, which is attached to the Si atom of Formula 1 via X:The block copolymers are suitable to improve fracture toughness of radically polymerizable compositions. These compositions are particularly suitable as dental materials.

CARDIAC PACEMAKER CONSTRUCT, METHOD FOR PRODUCING A CARDIAC PACEMAKER CONSTRUCT AND USE THEREOF

Resumen de: WO2024156635A1

The invention relates in a first aspect to a cardiac pacemaker construct comprising a three-dimensional core structure comprising pacemaker cells and fibroblasts, produced in vitro, or producible in vitro, by means of an additive manufacturing process and/or a moulding process. A second aspect of the invention relates to a method for producing a cardiac pacemaker construct, in particular a cardiac pacemaker construct according to the first aspect of the invention. A third aspect of the invention relates to a cardiac pacemaker construct obtained or obtainable by the method of the second aspect. A fourth aspect of the invention relates to the use of a cardiac pacemaker construct according to the first aspect, or a cardiac pacemaker construct according to the third aspect, for investigating the effect of substances, in particular harmful substances and/or medications, on the function of the sinoatrial node.

バイオプリンタのための着脱可能なプリンタヘッド及びバイオプリンタ

Resumen de: AU2023377822A1

A detachable printhead for a bioprinter is disclosed, the detachable printhead comprising a body, removably attachable to a fixed portion of the bioprinter; a dispensing system, supported by the body; one or more reservoirs, for holding one or more biomaterials, in fluid communication with the dispensing system, supported by the body; and a coupling for attaching to the fixed portion of the bioprinter, the coupling including an interface for operating the dispensing system.

一种牙套生产用3D打印设备

Resumen de: CN223618264U

本实用新型公开了一种牙套生产用3D打印设备，包括打印设备外壳、打印设备和打印件，所述打印设备外壳的底部内壁上开设有滑动槽，滑动槽内滑动安装有滑动块，滑动块的一端延伸至滑动槽内，滑动块的另一端延伸至滑动槽外，滑动块延伸至滑动槽外的一端固定安装有托板，打印设备外壳的一侧内壁上开设有开孔，托板的一端穿过开孔延伸至打印设备外壳外，托板的底部一侧固定安装有竖杆，打印设备外壳的一侧开设有凹槽，凹槽内滑动安装有横杆。该实用新型在打印设备内设有可水平移动的托板，可以在打印结束之后，水平移动托板，使得托板带动打印件滑出打印设备，可以降低打印件的冷却时间。

一种3D打印多孔椎弓根螺钉

Resumen de: CN223614912U

本实用新型公开了一种3D打印多孔椎弓根螺钉，包括钉身部和钉帽部，钉身部包括近钉帽部一端的皮质骨螺纹区和远离钉帽部一端的松质骨螺纹区，钉身部非连接钉帽部一端设有多孔结构区，多孔结构区包括沿钉身部轴向延伸的内芯柱、加强梁和多孔结构，加强梁至少设置一个且加强梁自内芯柱周缘向外延伸，多孔结构环布于内芯柱外周缘。本实用新型通过多孔结构能高效诱导骨组织长入，将螺钉与椎体连成一整体，有效分散应力，增加螺钉稳定性，多孔结构设于螺钉前端椎体部分，能够避免螺钉在椎弓根区域因应力集中导致螺钉断裂，同时，加强梁能够更好的提高螺钉稳定性，减少螺钉多孔区域断裂的可能，更具推广性且提升使用体验感。

一种多级仿生神经膜结构的神经导管制备方法和应用

Resumen de: CN121041508A

本发明公开了一种多级仿生神经膜结构的神经导管制备方法和应用，属于组织工程材料技术领域。本发明的多级仿生神经膜结构的神经导管，包含具有二级引导结构的仿生内膜支架和双层结构的仿生外膜支架。本发明的多级仿生神经膜结构的神经导管中，发挥生长引导作用的填充物具备多级引导结构，一级引导为细胞沿着定向纤维膜中的纤维方向定向迁移，在纤维上拉长形态，加速分化；二级引导为定向微通道约束神经纤维生长，促进集束成熟，对齐生长方向。本发明解决了现有方案存在的接触引导效率不足的问题，并克服了引导纤维填充密度、生长空间与引导效应之间的矛盾。

光敏陶瓷浆料与光固化3D打印生物陶瓷材料及其制备方法和应用

Resumen de: CN121041503A

本发明提供了光敏陶瓷浆料与光固化3D打印生物陶瓷材料及其制备方法和应用，属于医用生物材料技术领域。本发明提供的光敏陶瓷浆料，按质量份数计，包括以下组分：磷酸二氢铝溶胶50~55份，陶瓷粉末20~25份，单体10~15份，光引发剂0.05~0.10份，稳定剂0.01~0.05份，染料0.01~0.05份，水5~10份。本发明提供的光敏陶瓷浆料经3D打印后所得前驱体具有自由压缩复原、剪裁及个体化填补骨缺损部位的特点，打印过程中出现的瑕疵可以进行修剪，打印后所得前驱体结构出现轻微变形可以自行恢复，避免了光敏树脂经3D打印后存在结构固定、不能自由压缩和剪裁的问题。

一种血管支架及其制备方法

Resumen de: CN121042562A

本发明提出一种血管支架及其制备方法，对等原子比镍钛合金粉末进行逐层打印得到镍钛支架基体；在镍钛支架基体的表面原位生成氮化钛阻隔层；将表面改性后的镍钛支架置于熔融镁液中，进行无压渗透，以得到互穿相复合结构的Mg‑NiTi复合材料基体；对复合材料基体进行重熔，通过气流雾化制备得到复合材料细粉；采用选择性激光熔化技术和超快激光强化技术对复合材料细粉进行逐层打印，完成二次增材制造，以制备得到目标三维形态的血管支架。经本发明实施例提供的血管支架制备方法所制备的血管支架兼具高力学强度、可控降解周期，避免长期异物留存，可显著降低术后再狭窄率，适用于心血管、骨科等领域。

一种个性化牙齿3D打印设备及其方法

Resumen de: CN121043404A

本发明公开了一种个性化牙齿3D打印设备及其方法，涉及3D打印技术领域，包括打印主体，所述打印主体内设有用于存放液体树脂的树脂框，所述树脂框的上方装配有牵引组件，所述打印主体的前表面安装有能够操控牵引组件往复升降打印义齿的触摸操控屏，所述触摸操控屏的下方设有连接于打印主体前表面的门体；牵引组件包括固定于打印主体内壁的驱动部件。本发明通过铲除组件的设置，能够自动对义齿床上成型的义齿模具以及边料进行铲除，在铲除过程中，通过振动电机的设置，使得铲条能够往复横向振动，进而增加了铲除组件铲除义齿模具以及边料的稳定性，避免了因铲除力度过大而导致义齿模具出现损坏的情况。

一种基于3D打印的微流控芯片制备姜黄素缓释微球的方法

Resumen de: CN121041243A

本发明涉及生物医药材料及药物递送领域，具体涉及一种基于3D打印的微流控芯片制备姜黄素缓释微球的方法，包括：设计微流控芯片结构、利用光固化打印微流控芯片模具、翻模并键合芯片、连接微流控芯片制备姜黄素缓释微球。其中，连续相为含司盘80的矿物油溶液，分散相的成分包括Gelma溶液、姜黄素；将分散相和连续相按设定比例分别注入分散相流道和连续相流道，形成姜黄素液滴微球。本申请所述的方法可以提升姜黄素缓释微球的粒径均一性，提高姜黄素缓释微球的包载量，延长药物的释放周期，加大药物的利用效率。

用于生产三维丝网印刷工件的设备

Resumen de: WO2024188674A1

The invention relates to an apparatus for producing three-dimensional screen-printed workpieces, in particular a 3D screen printing installation, said apparatus comprising: a printing device for the layer-by-layer production of at least one screen-printed workpiece in a plurality of printing operations; and a transport device for the automated transport of at least one screen-printed workpiece and/or a workpiece carrier to and/or from the printing device, wherein the transport device has at least one transport rail and a conveyor vehicle, which is movably mounted on the transport rail, for at least one screen-printed workpiece and/or at least one workpiece carrier.

患者特异性血管介入球囊的3D打印模型生成系统

Resumen de: CN121043407A

本申请公开了患者特异性血管介入球囊的3D打印模型生成系统，包括影像建模模块从患者DICOM影像提取血管几何与解剖特征参数，生成带解剖特征标注的三维模型，为球囊设计提供基础；球囊构建模块依据血管三维模型中的血管曲率和弯曲动力学参数，标记高危区域并升级模型，设计出贴合血管实际的初始球囊三维模型；应力调整模块构建涵盖球囊多方面参数的规则库，通过仿真优化球囊应力分布，防止应力集中；打印处理模块根据优化后的球囊结构，利用3D打印实现材料分区与密度梯度控制，制造出患者专属球囊；此方案能提升球囊与血管的适配性，增强扩张效果，降低手术风险，有力支持个性化医疗。

用于制备糖尿病创面修复水凝胶的3D打印生物墨水及糖尿病创面修复水凝胶

Resumen de: CN121041510A

本发明公开了一种用于制备糖尿病创面修复水凝胶的3D打印生物墨水，包括组分A羟丁基功能化壳聚糖、组分B季铵基与醛基共修饰的甲壳素等；所述组分A由壳聚糖分散在NaOH溶液与异丙醇溶液中，与环氧丁烷反应制得；所述组分B由甲壳素分散在NaOH‑尿素溶液中，与2，3‑二氧基三甲基氯化铵反应，然后将产物分散在水中再与NaIO4反应制得。本发明的3D打印生物墨水，可以直接在伤患创面处进行原位打印形成修复水凝胶，能够完美贴合创面，该水凝胶利于伤口愈合，具备抗菌性能、对细胞无副作用，还可根据糖尿病创面在不同阶段需要不同药物的需求制备出负载不同药物的上下两层结构，实现在不同愈合阶段缓释不同药物，从而显著促进糖尿病等难愈合性创面的愈合。

3D打印正畸牙科矫治器的支撑结构及其制造方法

Resumen de: WO2024216245A1

The present disclosure provides a support of a 3D printed orthodontic dental appliance is provided. The orthodontic dental appliance includes a shell structure defined by an inner contour surface and an outer contour surface. The support comprises: a middle support including a middle support base mesh and a plurality of middle support struts and a main support configured to connect the middle support to a build platform of a 3D printing device used to print the orthodontic dental appliance. One end of each middle support strut of the plurality of middle support struts is connected to the orthodontic dental appliance at a junction of the inner contour surface and the outer contour surface, and the other end of the middle support strut is connected to a rim of the middle support base mesh.

用于治疗骨不连的骨整合式可降解硅胶支架及其制备方法

Resumen de: CN121041523A

本发明公开了用于治疗骨不连的骨整合式可降解硅胶支架及其制备方法，涉及医疗植入材料技术领域，该制备方法包括：使含氢硅油与烯丙基缩水甘油醚在铂催化剂作用下发生硅氢加成反应，生成含环氧基团硅油，随后在催化剂作用下使环氧基团开环，得到侧链含磷酸酯基团的硅油；将端羧基聚乳酸‑乙醇酸共聚物与侧链含磷酸酯基团的硅油混合，在缩合剂和催化剂作用下进行缩合反应，得到PLGA‑P‑PDMS‑PLGA三嵌段共聚物；将三嵌段共聚物、反应性稀释剂、光引发剂和无机增强填料混合制得3D打印浆料；使用光固化3D打印技术，根据设定的打印参数，将打印浆料打印成所设计的骨整合支架。通过本发明赋予了材料本征成骨活性，实现了生物活性、形状记忆功能与力学支撑的统一。

全光纤一体式探测消融诊疗仪及制备方法

Resumen de: CN121040956A

本发明公开了一种全光纤一体式探测消融诊疗仪及制备方法，属于光纤超声传感器与激光消融器领域。包括双包层光纤、介质膜、传感腔、微聚焦锥。双包层光纤用于探测光及消融激光的传输，介质膜和传感腔共同形成法布里珀罗（Fabry‑Pérot,FP）腔以传感超声信号，微聚焦锥提供超声聚焦的作用。本发明解决了现有光纤探测消融器件依赖多纤、结构复杂的问题，并解决了现有空心悬臂结构光纤超声传感器灵敏度较低、频带低的问题。

一种施源器及其制备方法

Resumen de: CN121041609A

本发明属于近距离放射治疗医疗器械技术领域，尤其涉及一种施源器及其制备方法，施源器采用3D打印技术制备，其原料各组分配比以质量百分比计，Cu：13‑15％，Zr：8‑10％，Mo：8‑10％，Nb：6‑9％，Sn：2.5‑3.5％，Si：0.5‑1.5％，余量为Ti。本发明通过添加Zr、Mo、Nb、Sn等低磁化率元素，将钛合金的磁化率降至纯钛磁化率的1/3，形成一种β相钛合金，再利用3D打印工艺和热等静压工艺制备成型为含ω相的钛合金施源器，其磁化率更小，使MRI成像伪影面积减少，源到位精度更高，降低了对危及器官的不利影响。

APPARATUS AND METHOD FOR 3D PRINTING PILLS WITH CUSTOM PROPERTIES

METHOD FOR GENERATING A PARTIALLY-CURED ITEM, A PARTIALLY-CURED ITEM AND A CURED OBJECT

Resumen de: EP4578633A2

The invention relates to a method for partial curing of an initial photoreactive material for 3D printing, comprising the steps of:a) providing an item (1) comprising the initial photoreactive material for 3D printing,b) a partial irradiation step comprising irradiating at least one curing section (20) of the initial photoreactive material for 3D printing of the item with a curing irradiation, yielding at least one cured section (120) of a partially-cured item (10), and at least one semi-curing section (40) of the initial photoreactive material of the item is irradiated with a semi-curing irradiation, yielding at least one semi-cured section (140) of the partially-cured item.

3차원 스크린-인쇄된 작업편을 생산하기 위한 장치, 및 이를 위한 방법

Resumen de: WO2024188675A1

The invention relates to an apparatus for producing three-dimensional screen-printed workpieces, in particular a 3D screen printing installation, said apparatus comprising: a printing device for the layer-by-layer production of at least one screen-printed workpiece in a plurality of printing operations; and a drying device which is designed to dry at least one screen-printed workpiece and to simultaneously cool a workpiece carrier that carries the screen-printed workpiece to be dried.

3차원 스크린-인쇄된 작업편을 생산하기 위한 장치, 및 이를 위한 방법

Resumen de: WO2024188676A1

The invention relates to an apparatus for producing three-dimensional screen-printed workpieces, in particular a 3D screen printing installation, said apparatus comprising: a printing device for the layer-by-layer production of at least one screen-printed workpiece in a plurality of printing operations; and a transport device for the automated transport of at least one screen-printed workpiece and/or a workpiece carrier to and/or from the printing device, the transport device having a support portion for at least interlockingly receiving a workpiece carrier.

复合3D环保打印材料的人体肋骨骼替代物制造方法、设备、存储介质

Resumen de: CN121018950A

本发明涉及复合3D环保打印材料的人体肋骨骼替代物制造方法、设备、存储介质，包括：步骤S100.基于患者受伤处的肋骨扫描，输出肋骨数据；步骤S200.在医学图像处理软件中基于所述肋骨数据生成肋骨三维模型；步骤S300.通过三维建模软件对肋骨三维模型进行优化，所述优化至少包括模型预处理、切片参数调整、打印路径规划和填充策略；步骤S400.将聚乳酸与连续纤维通过熔融堆叠形成复合材料，复合材料作为人体肋骨替代物的3D打印材料；步骤S500.采用3D打印技术对所述肋骨三维模型进行打印；步骤S600:对打印的人体肋骨骼替代物进行力学实验测试。

交联剂和组合物

Resumen de: US2024352174A1

The present disclosure provides cross-linker compounds that can produce desirable polymeric materials, polymer compositions, and/or photo-curable resins. Further provided herein are methods of producing cross-linker compounds, compositions, resins, devices, and polymeric materials. Also provided herein are methods of using cross-linker compounds, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.

适用于DLP 3D打印技术的齿科修复用复合材料及其制备方法

Resumen de: CN121015460A

本发明属于齿科陶瓷材料技术领域，具体涉及适用于DLP 3D打印技术的齿科修复用复合材料及其制备方法。所述的齿科修复用复合材料包括以下重量份数的原料：聚硅氮烷陶瓷先驱体粘结剂：30‑50份；氧化锆：60‑90份；光引发剂：3‑7份；热引发剂：2‑5份；分散剂：2‑6份；流变剂：1‑5份；硅烷偶联剂：3‑8份；烧结助剂：5‑10份；采用聚硅氮烷先驱体材料，通过光固化精确成型，再经热处理后可控转化为无机陶瓷，兼具有机物的加工性与陶瓷的高耐温、高稳定性，克服了传统有机粘结剂在高温下易分解、收缩大、强度不足的问题，为高性能陶瓷器件制备提供了新材料基础。

一种钛基复合材料的制备方法

Resumen de: CN121023285A

本发明公开了一种钛基复合材料的制备方法，该方法包括以下步骤：一、将氧化石墨烯分散液加入聚乙烯吡咯烷酮溶液中混合均匀，滴加硝酸银溶液进行自发反应，得到氧化石墨烯/纳米银复合粉末溶液；二、在氧化石墨烯/纳米银复合粉末溶液中加入钛或钛合金粉末，加热并进行超声机械搅拌，干燥后得到氧化石墨烯/纳米银+钛混合粉末；三、将氧化石墨烯/纳米银+钛混合粉末进行3D打印，得到钛基复合材料。本发明的制备方法通过在钛基表面构建氧化石墨烯和纳米银的共分散纳米结构，得到的钛基复合材料具有晶粒细化、高抗菌性、高耐磨性及高综合力学性能的特点，适用于医用钛及钛合金材料技术领域。

耳模制造方法、装置、系统、设备及存储介质

Resumen de: CN121018947A

本申请提供了一种耳模制造方法、装置、系统、设备及存储介质，涉及生物医疗技术领域，本申请预先对目标对象的耳郭取模得到耳郭反向模型，该耳郭反向模型真实表达了耳郭的所有曲面信息，通过扫描该耳郭反向模型得到三维点云数据，并基于三维点云数据构建得到的数字化耳郭正向模型，消除了耳部隐蔽曲面轮廓对点云数据采集的影响，有效实现了对耳郭完整曲面的数字化提取，提高了数字化构建实现耳模的精度，从而保证了数字化耳模与目标人员的耳部的契合度，并依据预设和提取耳郭的穴点信息，进行开孔，然后进行数字化耳模的实物打印，进行适合佩戴，方便进行个性化移动化诊治调理，实现了耳模数字化构建和可移动个性诊治调理的创新全流程。

Chemin d’air de ventilateur médical

Resumen de: FR3162365A3

Titre de l’invention Chemin d’air de ventilateur médical L’invention concerne un procédé de fabrication d’un chemin de gaz, de préférence d’air, pour ventilateur médical comprenant un ensemble de conduits ou de tronçons de conduits de gaz en communication fluidique les uns avec les autres. Au moins une partie de l’ensemble de conduits ou de tronçons de conduits de gaz est réalisée en mettant en œuvre un procédé de fabrication additive. Figure de l’abrégé : Figure 1

患者の口腔内の歯科的状況を治療する方法における使用のための硬化性組成物

Resumen de: CN120187382A

The present invention relates to a curable composition for use in a method of treating a dental condition in the oral cavity of a patient, the curable composition comprising a radiation curable component; a photoinitiator that exhibits absorption in the ultraviolet light region and exhibits absorption in the visible light region, the absorption in the ultraviolet light region being stronger than the absorption in the visible light region; optionally, a filler; optionally, an additive; the method comprises the steps of: layer-by-layer manufacturing of a dental or orthodontic article using radiation having a wavelength in the region of the ultraviolet light; attaching the dental or orthodontic article to a surface of hard dental tissue or dental material; radiation having a wavelength in the visible light region is applied to the dental or orthodontic article.

ADDITIVELY MANUFACTURED APPLIANCES WITH CELLULAR STRUCTURES

Resumen de: US2025359967A1

Intraoral appliances and associated systems are provided. In some embodiments, an intraoral appliance includes a 3D printed body composed of a plurality of additively manufactured layers. The 3D printed body can include a first cellular structure located at one or more first areas of the intraoral appliance, the first cellular structure corresponding to a first stiffness, and a second cellular structure located at one or more remainder areas of the intraoral appliance, the second cellular structure corresponding to a second stiffness less than the first stiffness.

ZINGEROL-BASED BIODEGRADABLE POLYESTERS AND 3D-PRINTABLE PHOTOPOLYMERIZABLE COMPOSITIONS, METHODS OF PREPARATION, AND USES THEREOF

Resumen de: US2025361358A1

The present invention provides novel polymeric materials for biomedical applications, derived from plant-derived phenolic diols, primarily zingerol. Two material classes are disclosed. First, biodegradable polyesters using said diols, are synthesized via solvent/catalyst-free melt polycondensation. These exhibit tunable mechanical properties, shape memory, antibacterial activity, and biocompatibility. Second, photopolymerizable zingerol derivative monomers or crosslinkers, are formulated into resins for 3D printing. Resulting 3D objects offer tailored mechanics, biodegradability, excellent shape memory, cytocompatibility, hemocompatibility, and potent antioxidant, antibacterial, and anti-biofilm functions. Methods for preparing both polymer types and their derivatives, alongside uses in tissue engineering and medical implants, are described.

RADIATION-CURING COMPOSITION FOR THE PRODUCTION OF DENTAL COMPONENTS

Resumen de: US2025361406A1

The invention relates to a radiation-curing composition for the manufacture of dental components using the DLP process or SLA process, comprising, based on the total mass of the radiation-curing composition (i) one or more radically polymerizable monomers in a combined mass fraction of 60% or more, (ii) one or more hexaarylbiimidazole compounds in a combined mass fraction in the range of 0.1 to 5%, and (iii) one or more mercaptotetrazole compounds in a combined mass fraction in the range of 0.1 to 5%, wherein the combined mass fraction of fillers in the radiation-curing composition is less than 30%.

ORAL DRUG DOSAGE FORMS FOR STOMACH RETENTION

Resumen de: US2025360081A1

Provided herein are drug dosage forms designed to provide a desired retention in an individual based on geometric differences between a pre-administration and post-administration state of the dosage form. In certain aspects, provided are oral drug dosage forms comprising a swellable and expandable material configured, upon swelling or expanding, to drive expansion of the overall size of the oral drug dosage forms such that the oral drug dosage forms are retained in the stomach for a desired period of time. In certain other aspects, provided is directed to components useful for the oral drug dosage forms taught herein. In certain other aspects, provided is directed to methods of designing, methods of making, such as involving three-dimensional (3D) printing, injection molding, ultrasonic welding, or any combination thereof, commercial batches, and methods of delivering a drug to an individual comprising administering an oral drug dosage form taught herein.

DENTAL DEVICE MANUFACTURING SYSTEM AND METHOD

Resumen de: US2025359966A1

A manufacturing system and method obtain a first digital model of teeth, create a modified digital model of the teeth by adding a locator feature to the first digital model of the teeth, and create a physical model of the teeth based on the modified digital model. A portion of the physical model is created based on the locator feature. A dental aligner device is formed on the physical model of the teeth with extraneous material of the dental aligner device extending away from the dental aligner device. The extraneous material is removed from the dental aligner device from the physical model of the teeth. The forming of the dental aligner device and/or the removing of the extraneous material is performed by positioning the physical model using the locator feature.

BIOSYMBIOTIC SYSTEMS FOR CHRONIC LONG-RANGE MONITORING OF BIOSIGNALS IN LIMITED RESOURCE SETTINGS

Resumen de: AU2024273563A1

The present disclosure provides a wearable article including a 3D printed base, 3D printed antenna ground plane structure and a 3D printed a dipole antenna structure, wherein the base, ground plane structure and dipole antenna structure comprises a 3D printed mesh which is formed of a stretchable elastomeric polymer material. The wearable article also includes signal transmission and power harvesting circuitry comprising duplexing circuit to transmit and receive data and to receive wireless power from a power transmission unit.

3D PRINTING OF ORGANOID SLURRIES

Resumen de: WO2025245459A1

A method for preparing a tissue, comprising depositing a cell bioink in a biocompatible matrix to form a printed cell structure in the biocompatible matrix; and allowing the printed cell structure to incubate in the biocompatible matrix for a time sufficient for at least a portion of cells of the printed cell structure to develop into a contiguous tissue before removing the printed cell structure from the biocompatible matrix; wherein the biocompatible matrix has a yield stress greater than a yield stress of the cell bioink, prior to depositing the cell bioink in the biocompatible matrix, and the biocompatible matrix optionally comprises a rheological modifier.

REINFORCED ENGINEERED CELLULARIZED-TISSUE

Resumen de: US2025361480A1

A method for generating reinforced engineered cellularized construct, which utilizes a biocompatible small-molecule reinforcing agent that do not affect the viability of the cells, a reinforced engineered cellularized construct obtained thereby and used the engineered cellularized construct are provided.

MANUFACTURING PROCESSES FOR BIOPOTENTIAL-BASED WRIST-WEARABLE DEVICES AND RESULTING MANUFACTURED BIOPOTENTIAL-BASED WRIST-WEARABLE DEVICES

Resumen de: US2025362752A1

A wrist-wearable device is described herein. The wrist wearable device includes a first skin-contact portion. The first skin contact portion (i) is coupled with a first set of biopotential-signal sensors for detecting first biopotential signals that are provided to a first flexible printed circuit board, and (ii) is coupled with an elastic material that extends beyond an end of the first skin-contact portion. The wrist wearable device includes a second skin-contact portion that is separated from the first skin-contact portion by a capsule structure. The second skin-contact portion is (ii) coupled with a second set of biopotential-signal sensors for detecting biopotential signals that are provided to a second flexible printed circuit board, and (ii) is coupled with a receiving loop for receiving the elastic material to affix the band to a body part of a wearer of the wrist-wearable device.

DEVICES AND METHODS FOR STENT GRAFT EXTRACTION

Resumen de: US2025360010A1

A method of extracting an implant from a vessel includes inserting an extraction device into the vessel. The extraction device includes a hollow body having a cylindrical portion and a bellowed portion. An inner diameter of the bellowed portion increases toward an end of the hollow body. The method also includes sliding the extraction device over an outer surface of the implant such that the hollow body slides between a vessel wall and the implant to move the implant from a deployed position to a non-deployed position within the hollow body. The method can also include removing the extraction device and the implant from the vessel.

PART FOR COVERING A BONE DEFECT

Resumen de: WO2025242824A1

The present invention relates to a method for manufacturing a covering part for a device intended for bone regeneration, in order to cover a bone defect in a patient, which method comprises the steps of a) recording a set of data representative of the stated bone defect in three dimensions; b) designing the covering part using this set of data, which covering part has a wall opposite the bone defect and a wall facing the bone defect, and which covering part is able to be fastened in place on a bone by at least one fastening means; and c) manufacturing the covering part, wherein the covering part is made from a resorbable polymer by 3D printing, has microperforations, and has a thickness of between 0.8 and 1.5 mm.

Method of Designing and Manufacturing an Elastic Circumferential Rim of a Prosthetic or Orthotic Device

Resumen de: US2025360004A1

A method of designing and manufacturing an elastic circumferential rim of a prosthetic or orthotic device includes a step of creating a basic structure of the elastic circumferential rim based on the type of the prosthetic or orthotic device. Requirements are determined for stiffness of the elastic circumferential rim in the individual areas along the circumference of the elastic circumferential rim. A structural model of the elastic circumferential rim is created based on the requirements for stiffness of the elastic circumferential rim in the individual areas along the circumference of the elastic circumferential rim and the basic structure of the elastic circumferential rim. The elastic circumferential rim is manufactured based on the structural model of the elastic circumferential rim.

MULTIVASCULAR NETWORKS AND FUNCTIONAL INTRAVASCULAR TOPOLOGIES WITHIN BIOCOMPATIBLE HYDROGELS

Resumen de: EP4653192A2

A device made from a hydrogel matrix is provided. The hydrogel matrix includes a photoabsorber with a void architecture in the matrix, having a first vessel architecture and a second vessel architecture that are each tubular and branching, wherein the first and second vessel architectures are fluidically independent from each other. A pre-polymerization solution for forming the device, and methods of fabricating such devices are described. A method of fabricating a 3D hydrogel construct is provided. The method includes using a computer-implemented process to create a 3D model of the construct based on a tessellation of polyhedra having a number of faces connected by edges and vertices, generate a first vascular component of the model, generate a second vascular component of the model, and combine the first and second vascular components of the model.

RADIATION-CURABLE COMPOSITION FOR THE PRODUCTION OF DENTAL COMPONENTS

Resumen de: EP4652981A1

Die Erfindung betrifft ein eine strahlungshärtende Zusammensetzung für die Herstellung dentaler Bauteile im DLP-Verfahren oder SLA-Verfahren, umfassend bezogen auf die Gesamtmasse der strahlungshärtenden Zusammensetzung: i) ein oder mehrere radikalisch polymerisierbare Monomere in einem kombinierten Massenanteil von 60 % oder mehr, ii) eine oder mehrere Hexaarylbiimidazol-Verbindungen in einem kombinierten Massenanteil im Bereich von 0,1 bis 5 %, und iii) eine oder mehrere Mercaptotetrazol-Verbindungen in einem kombinierten Massenanteil im Bereich von 0,1 bis 5 %, wobei der kombinierte Massenanteil an Füllstoffen in der strahlungshärtenden Zusammensetzung weniger als 30 % beträgt.

POLYMER-PHOSPHATE-BASED COMPOSITION FOR 3D PRINTED IMPLANTS

Resumen de: EP4653024A1

The invention provides a composition for low-temperature 3D printing of tissue implants, which contains:- calcium phosphate powder,- chitosan particles,- aqueous solution of block copolymer (D,L-polylactide-co-polyglycolide)-b-poly(ethyleneglycol)-b-(D,L-polylactide-co-polyglycolide) (PLGA-PEG-PLGA).A kit and a method for preparing the composition are provided, as well as a method for printing tissue implants using the kit.

3차원 스크린 인쇄된 작업편을 생산하기 위한 장치, 및 이를 위한 방법

Resumen de: WO2024188678A1

The invention relates to a workpiece carrier, in particular for producing three-dimensional screen-printed workpieces, said workpiece carrier comprising: at least one printing bed which has a printing surface to be printed; and a support structure which supports the printing bed and is formed separately from the printing bed, it being possible to optically detect the position and/or orientation of the printing bed starting from a side of the support structure facing away from the printing bed.

METHOD AND APPARATUS FOR GENERATING DIGITAL MODEL OF CORRECTIVE DEVICE, AND MANUFACTURING METHOD FOR CORRECTIVE DEVICE

Resumen de: EP4652960A1

A method for generating a digital model of an orthodontic appliance, which comprises: determining overall size information and alveolar size information for a digital model of an orthodontic appliance according to information related to different dentition areas of a target oral cavity digital model; and generating the digital model of the orthodontic appliance according to the overall size information and the alveolar size information. Further provided are an apparatus for generating a digital model of an orthodontic appliance using the method for generating a digital model of an orthodontic appliance, as well as an orthodontic appliance manufactured using the method for generating a digital model of an orthodontic appliance. The method for generating a digital model of an orthodontic appliance can improve production efficiency and product precision of orthodontic appliances.

一种牙套热压膜及其制备方法

Resumen de: CN121005881A

本发明公开了一种牙套热压膜的制备方法。该热压膜先对苯二甲酸通过单氯甲基化进行季铵化反应，再与改性乙二醇单体单体进行共聚反应形成改性后的聚酯，最后与季戊四醇反应得到星形交联的聚对苯二甲酸乙二醇酯；得到所需材料后，通过仪器获取口内数字模型并3D打印牙颌模型；采用一体式热压成型工艺将产物热压成型后，裁剪打磨抛光，得到牙套热压膜。本发明力学性能与弹性优势并存，拉伸强度30‑40MPa，断裂伸长率≧8%，玻璃化温度在60℃到70℃之间，结构稳定且抗菌效果好，对常见细菌杀灭率超96%。采用3D打印与热压成型结合，提升生产效率与精度，产品透明美观、方便摘戴，兼具化学稳定性，适合规模化生产。

用于增材制造的模块化构建平台

Resumen de: US2024100775A1

Systems, methods, and devices for additive manufacturing are provided. In some embodiments, a method includes: coupling a plurality of build platforms to a carrier; forming a plurality of 3D objects on the plurality of build platforms using an additive manufacturing process, where each build platform receives at least one 3D object thereon; removing the plurality of build platforms from the carrier; performing post-processing of the plurality of 3D objects while the 3D objects remain on the respective build platforms; and separating the plurality of 3D objects from the respective build platforms.

一种用于建立骨不连动物模型的隔离器及其制备方法

Resumen de: CN121006015A

本发明公开了一种用于建立骨不连动物模型的隔离器及其制备方法，涉及医疗器械技术领域，包括如下步骤：步骤一：得到侧链含有Si‑H键的含氢硅油预聚物；步骤二：得到侧链带环氧基的硅胶大分子单体；步骤三：得到抗炎功能化硅胶大分子单体；步骤四：三维重建骨骼模型，创建缺损处隔离器模型；步骤五：将步骤三中得到的抗炎功能化硅胶大分子单体与活性稀释剂加入配料罐，机械搅拌下加入交联剂，加入聚醚改性聚二甲基硅氧烷，搅拌30分钟，在500Pa真空下脱泡2小时，脱泡后暗室中静置熟化；步骤六：采用多料盒DLP光固化3D打印机进行隔离器打印，本发明从根本上减少了对骨不连病理过程的观察干扰，实现了高保真建模构建。

3D Device and method for manufacturing customized 3D printed surgical stents

Resumen de: WO2025239483A1

The present invention relates to an apparatus and a method for manufacturing a customized 3D-printed upper-jaw fixation device. The apparatus for manufacturing a customized 3D-printed upper-jaw fixation device according to an embodiment of the present invention may comprise: a scanning unit for collecting a digital impression of an oral cavity through an intraoral scanner; a design unit for setting an engagement of a clasp by considering positions of teeth and a buccal surface in the digital impression; an output setting unit for setting a thickness and applying an offset to the digital impression in which the clasp engagement is set so as to generate an output file; and a printing unit for outputting the upper-jaw fixation device on the basis of the output file.

METHOD FOR DESIGNING CUSTOMIZED IMPLANTS FOR PATIENTS WITH BONE DEFECTS AND SERVER FOR PROVIDING THEREOF

Resumen de: WO2025239593A1

A method for designing a patient-customized implant for a bone defect site comprises the steps of: extracting, by a processor, a 3D image of a bone defect site; designing a 3D shape-based implant on the basis of the extracted 3D image of the bone defect site; calculating the direction and magnitude of partial loads received when the designed 3D shape-based implant is inserted into the bone defect site; designing, on the basis of the direction and magnitude of the partial loads, porosity of the designed 3D shape-based implant, the shape of solid metal, and the degree of porosity; and displaying, to a user, the designed 3D shape-based implant on the basis of the determined porosity, shape of solid metal, and degree of porosity.

치과 기구의 자동 마킹을 위한 기법

Resumen de: MX2025011659A

The present disclosure discusses techniques for marking a dental appliance. A dental model and dental appliance are positioned onto a conveyor tray, which is transported to a scan station. The dental model and conveyor tray each include an identifying code. The scan station includes a camera and barcode reader to read the identifying codes on the dental model and conveyor tray, and these codes are associated with one another. The conveyor tray then moves to a marking station where a barcode reader reads the code on the conveyor tray, and then marks the dental appliance with the appropriate marking.

FREMGANGSMÅDE OG INDRETNING TIL DATAMATCHING AF ORAL MODEL

Resumen de: US2023076682A1

The present disclosure relates to a method and device for matching oral model data that can provide matching points to a user to match oral model data and computerized tomography (CT) data even for edentulous patients. In this way, convenience is increased and matched data can be effectively generated even for edentulous patients for whom matching has been difficult conventionally.

다기능 치과용 디바이스 및 연관된 방법

Resumen de: CN120379615A

The invention relates to a kit (100) consisting of a device for gradually changing the position of teeth of a person (P), comprising at least two devices (10), each device (10) comprising at least one jaw device (11, 12), the at least one jaw device (11, 12) being designed such that a receiving region of the jaw device (11, 12) can be placed on a dental arch of an upper jaw (OK, 5) or a lower jaw (UK, 4) of the person (P), the device (10) is designed in such a way that, when the device is worn according to a predetermined sequence of the device (10), the device progressively changes the tooth position by mechanical interaction of the device and the at least one tooth element. The at least one jaw device (11, 12) of the first device (10.1, 10.2) can have a first contact element (N.I.1.2, N.IV.1.2) on the outer side thereof as a sub-region of the first device (10.1, 10.2). The at least one jaw device (11, 12) of the second device (10. N) can have a second contact element (N.I.1. N, N.IV.1. N) on the outer side thereof as a sub-region of the second device (10). The first facing element (N.I.1.2, N.IV. 1.2) can be located at the same position as the second facing element (N.I.1. N, N.IV. 1. N) according to the dental scheme. The receiving region of the first facing element (N.I.1. 1.2, N.IV.1. 1.2) can be designed differently from the receiving region of the second facing element (N.I.1. N, N.IV.1. N) and/or has a different position from the receiving region of the second facing

制造牙科物体的方法、制造物体的系统以及方法

Resumen de: CN120983168A

本发明提供了一种制造牙科物体的方法、制造物体的系统以及方法，制造牙科物体的方法，牙科物体包括基托和牙齿，方法包括：获取牙科物体的初始数据模型；沿至少一个方向，使牙科物体的初始数据模型的厚度增加预定值以获得目标数据模型；基于目标数据模型，一体制造目标物体，其中目标物体包括基托部分和牙齿部分，基托部分包括第一材料，牙齿部分包括不同于第一材料的第二材料；对目标物体进行处理，以沿至少一个方向减少目标物体预定值的厚度，从而获得牙科物体。本申请的技术方案有效地解决了相关技术中的需要人工粘结和打磨进而增加了生产成本的问题。

一种血糖响应型水凝胶

Resumen de: CN120983700A

本发明属于医学制药领域，具体提供一种血糖响应型水凝胶，所述血糖响应型水凝胶通过3D打印和同步光固化法形成，且由A层和B层交替层叠形成；所述A层包括生物墨水、抗炎组分和葡萄糖氧化酶，所述B层包括生物墨水和过氧化氢酶；所述生物墨水包括甲基丙烯酰化壳聚糖、用于光固化的光引发剂和用于增强力学性能的羟基磷灰石，所述抗炎组分选自银离子、抗生素和白细胞介素抗体中的一种或多种。本发明使用葡萄糖氧化酶和过氧化氢酶，二者联合配合使用，通过3D打印和分层载酶方法搭载在水凝胶上，对血糖的敏感性更好。本发明提供的血糖响应型水凝胶CH/IL‑17Abs@GOx/CAT具备优异的葡萄糖响应性与细胞相容性。

一种光固化制备透光渐变多色氧化锆材料制备方法

Resumen de: CN120987636A

本发明公开了一种光固化制备透光渐变多色氧化锆材料制备方法，制备改性氧化铝，所述改性氧化铝为氧化铝表面附着锶元素和铬元素；通过所述锆铝粉料制备底层料浆、中间层料浆、上层料浆；所述底层料浆包括锆铝粉料、着色剂；所述中间层料浆包括锆铝粉料、透光助剂、着色剂；所述上层料浆包括锆铝粉料、透光助剂、着色剂；通过光固化料浆通过3D打印，用底层料浆制备底层坯体，用中间层料浆在底层坯体表面制备中间层坯体，用上层料浆在中间层坯体表面制备上层坯体，从而得到氧化锆材料坯体；实现通过3D打印直接制备透光渐变、颜色渐变的透光渐变多色氧化锆材料，实现透光渐变多色氧化锆材料更接近真实牙齿颜色，且强度与韧性不降低。

一种用于经皮跟骨置钉术的3D打印跟骨置钉导板及其制备方法

Resumen de: CN120983131A

本发明涉及骨科手术器械领域，尤其涉及一种用于经皮跟骨置钉术的3D打印跟骨置钉导板及其制备方法，包括：板体和引导部；其中，板体具有内表面和与内表面相对设置的外表面，板体的内表面为与足跟表面轮廓相适配的贴合曲面；引导部固定地设置于板体的外表面上，且引导部位于板体的外表面的中部区域；引导部包括固定地设置于板体外表面上的若干置钉导柱、以及沿置钉导柱中轴线开设的置钉孔；置钉孔贯穿板体；本发明的3D打印跟骨置钉导板通过基于患者个体解剖特征的设计和3D打印制造，实现了经皮跟骨置钉术的精准引导，有效解决了传统经皮手术依赖术者经验导致的精准度不足问题。

用于3D打印聚合物树脂的添加剂

Resumen de: US2025346703A1

The present disclosure provides micelles comprising a plurality of block co-polymers, the micelle comprising (i) a core comprising at least a portion of a poly(alkyl acrylate) block of one or more of the block co-polymers; and (ii) an outer layer comprising at least a portion of a poly(aryl acrylate) block or a poly(aryl methacrylate) block of one or more of the block co-polymers. The present disclosure also includes polymer compositions, polymer films, and devices (e.g., orthodontic equipment) including the same. Methods for making and using micelles, polymer compositions, polymer films, and devices (e.g., orthodontic equipment) are also disclosed. Further provided herein are methods of producing polymer compositions and using the same for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.

用于3D打印树脂的单体化合物

Resumen de: US2024376039A1

The present disclosure provides monomer compounds that can produce desirable polymeric materials and photo-curable resins. Further provided herein are methods of producing compounds, compositions, resins, devices, and polymeric materials. Also provided herein are methods of using compounds, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.

一种拓扑机械异质结构水凝胶支架及其一体化3D打印制备方法和应用

Resumen de: CN120983699A

本发明属于生物材料与组织工程技术领域，具体涉及一种拓扑机械异质结构水凝胶支架及其一体化3D打印制备方法和应用。本发明提供的拓扑机械异质结构水凝胶支架，是一种拓扑结构的一体化3D水凝胶支架，结构包括纳米多孔软骨层和分级多孔骨层，纳米孔层和分级大孔层孔隙协同，兼具梯度力学性能、连续孔隙结构和生物活性可控三重功能，解决了骨软骨修复中的分层、力学失效及机制不明问题。本发明还提供了上述方案所述拓扑机械异质结构水凝胶支架的一体化3D打印制备方法。本发明提供的制备方法步骤简单，操作方便，可行性高。

TUMOR MODEL AND PROCESS OF PREPARATION THEREOF

Resumen de: WO2025237975A1

The present invention refers to a process for preparing a three-dimensional tumor model having a core-shell structure using bioprinting techniques leading to tumor models capable of better reproducing the physiopathological complexity of real tumors, mimicking the tumor microenvironment and the original tumor tissue extracellular matrix. The process is based on the use of dECM (decellularized extracellular matrix) bioinks but with the particularity that no exogenous biopolymers that modify the rheological properties to improve printability are needed. The absence of rheological modifiers in the bioinks avoids any kind of physical or biochemical interference in the tumor model so obtained.

PREPARATION METHOD OF A HIP JOINT BONE CEMENT PLACEHOLDER

Resumen de: US2025352364A1

Disclosed are a metal inner core, a placeholder and a preparation method for a hip joint bone cement placeholder. By designing the metal inner core including a frame body and a supporting portion inside the hip joint bone cement placeholder, the strength of the placeholder is enhanced; due to the fact that the metal inner core is hollow, the antibiotic bone cement can fill the inner portion of the metal inner core, the content of antibiotics in the placeholder cannot be affected, and infection is effectively controlled; the hollowed-out structure endows the placeholder with lighter weight and stronger structural strength, and meanwhile, the material cost is effectively reduced; and according to the preparation method of the hip joint bone cement placeholder, the size design of the placeholder and the metal inner core is carried out, so that the joint matching degree between the placeholder and the patient is high.

GYNECOLOGICAL PROTHETIC WITH ANCHOR MEMBERS AND EXPANDABLE CONNECTING LINKS, AND METHOD FOR CUSTOM-DESIGNNG THE SAME

Resumen de: US2025352320A1

Disclosed is a gynecological prosthetic including a plurality of anchor members configured to rest on anchor points within a vagina, and a plurality of connecting links that couple the anchor members together. The connecting links are configured to be compressible to enable a compact state when the gynecological prosthetic is being installed in the vagina. Also, the connecting links are configured to be expandable from the compact state after the gynecological prosthetic is installed in the vagina so as to push the anchor members outward against inside surfaces of the vagina to resist displacement of the gynecological prosthetic. This gynecological prosthetic can have a better fit to an anatomical shape of an upper vagina compared to current gynecological prosthetics, in part because its design and flexibility enable it to expand in certain directions. Also disclosed is a method and apparatus for custom-designing the gynecological prosthetic.

REMOTE TRACKING AND APPROVAL OF MEDICATION DELIVERY

Resumen de: US2025353632A1

A system for dispensing and verifying a dosage in a bottle. The system includes a stage for holding the bottle. The system further includes a pump-printer module, configured to receive a set of dosage specifications. The module includes a dosage dispenser configured to fill the bottle with the dosage according to the set of dosage specifications, and a printer device configured to print and apply a label onto the bottle listing out the set of dosage specifications. The dosage dispenser and the printer device are configured to operate simultaneously. The system further includes one or more imaging components disposed optically in-line with the stage, configured to capture a plurality of images of the bottle and the label.

HIGH EFFICIENCY ARCHITECTURES FOR SELECTIVE TRANSPORT ACROSS FLUID NETWORKS IN ORGAN SYSTEMS, AND SYSTEMS AND METHODS FOR GENERATING THEREOF

Resumen de: WO2025240824A2

Systems and methods for designing and generating architectures for the selective transport across fluid networks in 3D printed organ systems are provided. An example method includes: identifying, two or more fluid networks of a reference organ system and a transport characteristic between the two or more fluid networks; generating a model of each fluid network that includes channel parameters for channels associated with the fluid network; determining, based on the transport characteristic, a wall thickness between a channel of one fluid network, to a channel of another fluid network, for each of the two or more fluid networks; integrating the models of each fluid network to generate an organ system model that includes at least a representation of the functional region based on the wall thicknesses between respective channels between the two or more fluid networks; and generating a 3D printed organ system based on the organ system model.

3D-PRINTED ORTHOSIS AND METHOD FOR PRODUCING SAME

Resumen de: WO2025236022A1

The invention relates to a method for producing an orthosis (21), characterised by the steps of: - providing a multi-axis 3D printer for printing a continuous fibre (30), - printing a first support section (22) of the orthosis (21), wherein the continuous fibre (30) is printed in curved areas (F1, F2) and/or flat areas arranged at an angle to one another other. The invention further relates to an orthosis produced by said method and to a computer-implemented method for determining control commands for a 3D printer for the 3D printing of said orthosis.

CUSTOMIZABLE FITTED APPARATUS

Resumen de: US2025352382A1

A customizable fitted device for immobilizing injuries and a method for constructing the fitted device is provided. The fitted device can be used to stabilize an arm, wrist, hand, leg, knee, ankle, foot or other body parts through custom formation. The device can be formed by a sidewall having one or more sidewall sections that can be secured together using retaining clips positioned within retaining clip slots on the device. The device can further include one or more openings defined in the sidewall of each device section while maintaining rigidity in the sidewall. The device can be constructed by of creating a 3D image scan of the particular body part on which the device will be applied, creating a design of the device to precisely match the contours of the 3D image scan, and using a 3D printer to construct the device according to the design.

IMPLANT CUSTOMIZED FOR PATIENTS WITH BONE DEFECTS, METHOD FOR DESIGNING SAME, AND PROGRAM AND SERVER THEREFOR

Resumen de: WO2025239593A1

A method for designing a patient-customized implant for a bone defect site comprises the steps of: extracting, by a processor, a 3D image of a bone defect site; designing a 3D shape-based implant on the basis of the extracted 3D image of the bone defect site; calculating the direction and magnitude of partial loads received when the designed 3D shape-based implant is inserted into the bone defect site; designing, on the basis of the direction and magnitude of the partial loads, porosity of the designed 3D shape-based implant, the shape of solid metal, and the degree of porosity; and displaying, to a user, the designed 3D shape-based implant on the basis of the determined porosity, shape of solid metal, and degree of porosity.

APPARATUS AND METHOD FOR MANUFACTURING CUSTOMIZED 3D-PRINTED UPPER-JAW FIXATION DEVICE

Resumen de: WO2025239483A1

The present invention relates to an apparatus and a method for manufacturing a customized 3D-printed upper-jaw fixation device. The apparatus for manufacturing a customized 3D-printed upper-jaw fixation device according to an embodiment of the present invention may comprise: a scanning unit for collecting a digital impression of an oral cavity through an intraoral scanner; a design unit for setting an engagement of a clasp by considering positions of teeth and a buccal surface in the digital impression; an output setting unit for setting a thickness and applying an offset to the digital impression in which the clasp engagement is set so as to generate an output file; and a printing unit for outputting the upper-jaw fixation device on the basis of the output file.

A MULTI-TECHNOLOGY PRINTING SYSTEM

Resumen de: WO2025238634A1

A system for performing substrateless and/or local donor Laser Induced Forward Transfer (LIFT), comprising a reservoir comprising at least one opening and an energy source configured to deliver energy to a donor material within said reservoir, characterized by at least one of: said reservoir is embedded into a medical device; said reservoir is in fluid connection with a medical device; said reservoir is incorporated into a medical device; said reservoir contains at least one biologically active substance; and, said reservoir is in fluid connection with at least one source of at least one biologically active substance. This system enables deposition of material by LIFT without any need for a donor substrate. Methods of substrateless and local donor LIFT, in particular for medical and biological applications, are also disclosed.

TACTILE DIFFERENTIATION OF DRUGS FOR THE BLIND AND VISUALLY IMPAIRED

Resumen de: WO2025238558A1

Disclosed is a system and method for providing solutions for differentiating medications for blind and visually impaired patients. Applicant provides for a method of medication management that enables a user to differentiate solid and semi-solid dose forms using non-visual sense, namely tactical. By configuring a top, bottom, edge or side of said device to have one or more raised or indented letters, symbols, figures, logos, geometric figures, markings or textural differences, or any combination thereof, or in any variable shape and size thereof, to induce a tactile sensation, the system and method disclosed herein provide for on-dose tactile features that can improve the ability of patients to tell medications apart by touch and can be scaled into tablet manufacturing.

TUMOR MODEL AND PROCESS OF PREPARATION THEREOF

Resumen de: EP4650437A1

The present invention refers to a process for preparing a three-dimensional tumor model having a core-shell structure using bioprinting techniques leading to tumor models capable of better reproducing the physiopathological complexity of real tumors, mimicking the tumor microenvironment and the original tumor tissue extracellular matrix. The process is based on the use of dECM (decellularized extracellular matrix) bioinks but with the particularity that no exogenous biopolymers that modify the rheological properties to improve printability are needed. The absence of rheological modifiers in the bioinks avoids any kind of physical or biochemical interference in the tumor model so obtained.

BIOMETRIC MODEL OF FIBROSIS

Resumen de: WO2024150259A1

Method for producing a biomimetic model of fibrosis which comprises the steps of: associating at least one cell type with at least one bio-ink containing collagen, obtaining a first compound; depositing said first compound in a culture medium obtaining a first deposited compound; keeping said first deposited compound in said culture medium for a period of time longer than 1 day, preferably comprised between 2 and 5 days; adding a profibrotic factor TGF-beta (TGFP) to said first deposited compound, obtaining a second added compound; keeping said second added compound in said culture medium for an additional period of time longer than 1 day, preferably comprised between 2 and 7 days; a biomimetic model of fibrosis which comprises at least one cell type associated with at least one bio-ink containing type I collagen and at least one profibrotic factor TGFβ is added to said bio-ink.

METHODS FOR GENERATING SUPPORT STRUCTURES FOR ADDITIVELY MANUFACTURED OBJECTS

Resumen de: US2024227300A1

Methods and systems for generating support structures for additively manufactured objects are described herein. In some embodiments, a method includes receiving a digital representation of a dental appliance configured to implement a treatment stage of a treatment plan for a patient's teeth. The method can include generating a support structure arrangement configured to support the dental appliance during an additive manufacturing process. The support structure arrangement can be generated using a machine learning model. The machine learning model can be trained on a training data set including appliance data representing geometries of a plurality of dental appliances, support structure data representing geometries of a plurality of support structure arrangements, and outcome data representing outcomes of the additive manufacturing process for the plurality of dental appliances with the respective support structure arrangements.

一种腰椎压缩性骨折俯卧过伸复位手术垫板制备方法

Resumen de: CN120959957A

本发明属于医疗器械技术领域，涉及一种腰椎压缩性骨折俯卧过伸复位手术垫板的制备方法，包括以下步骤：收集患者胸腰椎影像学资料(X线片和CT图像)；通过三维重建软件生成腰椎三维立体模型；分析骨折椎体解剖学关系；利用Surgimap软件进行3D过伸位复位模拟，计算过伸角度(β‑α)，生成胸部垫子和髂部垫子的三维数字化模型；采用3D打印技术制作手术垫板，表面覆盖泡沫或硅胶软垫。本方法基于患者个性化数据，精准设计垫板参数，使腰椎稳定于过伸位，显著提高复位效果，降低手术难度和并发症。适用于PVP、PKP等手术，制作成本低，易推广，改善患者预后。

一种非均匀融合结构多孔陶瓷及其制备方法与应用

Resumen de: CN120965363A

本申请公开了一种非均匀融合结构多孔陶瓷的制备方法，包括：步骤一、构造融合函数，确定融合函数的参数；步骤二、制备蜡型负模板；步骤三、配置陶瓷浆料；步骤四、浸渍、冷冻；步骤五、低压干燥；步骤六、烧结，获得TPMS结构多孔陶瓷。本申请还包括一种非均匀融合结构多孔陶瓷。本申请还包括非均匀融合结构多孔陶瓷在仿生骨支架领域中的应用。本申请融合G形函数和TPMS函数构造融合函数，实现多种孔型的非均匀融合；采用蜡质负模板冷冻铸造，间接成型的方式，保留了复杂结构的设计自由度的同时，解决了直接3D打印多孔陶瓷时面临的分辨率限制、收缩变形和支撑困难等问题，使用效果好。

3D Multi-purpose wear-resistant dental 3D printing resin composition and manufacturing method of dental medical supplies using the same

Resumen de: KR20250161722A

본 발명은 다용도 내마모성 치과용 3D 프린팅 레진 조성물 및 이를 이용한 치과용 의료물품의 제조방법에 관한 것이다. 더욱 상세하게는, 본 발명은 무기 필러를 포함하지 않으면서도 내마모성 등 우수한 기계적 특성을 가지며, 치과용 모형(model), 주조품(casting), 의치(denture), 및 임시치(temporary crown & bridge) 등의 제조에 적합하게 이용될 수 있는 다용도 내마모성 치과용 3D 프린팅 레진 조성물 및 이를 이용한 치과용 의료물품의 제조방법에 관한 것이다.

BONE STABILIZING IMPLANTS ACROSS SI JOINTS

Resumen de: AU2025230762A1

Abstract The invention relates to a threaded bone implant, comprising: an elongate body extending from a proximal end of the bone implant to a distal end of the bone implant, the elongate body including an inner shank, one or more threads, each of which extend radially from the inner shank and extend along at least a portion of a length of the elongate body, a porous network of interconnected struts extending radially from the inner shank and disposed and extending axially between the one or more threads, the inner shank, the one or more threads, and the porous network of interconnected struts being formed together with an additive manufacturing process such that the inner shank, the one or more threads, and the porous network of interconnected struts are integral, and wherein the porous network of interconnected struts has a greater surface area in a central region of the elongate body than in a distal region of the elongate body, wherein the central region includes a midpoint of the length of the elongate body. Abstract The invention relates to a threaded bone implant, comprising: an elongate body extending from a proximal end of the bone implant to a distal end of the bone implant, the elongate body including an inner shank, one or more threads, each of which extend radially from the inner shank and extend along at least a portion of a length of the elongate body, a porous network of interconnected struts extending radially from the inner shank and disposed and extending a

ORAL MODEL DATA MATCHING METHOD AND DEVICE

Resumen de: US2023076682A1

The present disclosure relates to a method and device for matching oral model data that can provide matching points to a user to match oral model data and computerized tomography (CT) data even for edentulous patients. In this way, convenience is increased and matched data can be effectively generated even for edentulous patients for whom matching has been difficult conventionally.

一种用于眼部疾病治疗的跨巩膜持续给药装置

Resumen de: CN223555063U

本实用新型公开一种用于眼部疾病治疗的跨巩膜持续给药装置，包括圆弧体、翼型固定板和固定带；圆弧体的底面开设有凹槽；两翼型固定板对称设置在圆弧体的两侧；两翼型固定板分别纳入外直肌的肌腹下和下直肌的肌腹下；若干固定带固接在圆弧体的底面上，固定带与凹槽的内壁之间设有间隙，间隙用于存放药膜；两翼型固定板远离圆弧体的一端设有间隔，圆弧体和两翼型固定板整体呈C字形。本实用新型能良好贴合眼球、减少对眼球的压迫，从而不影响眼球自由转动，提高佩戴舒适感及药物生物利用度，减少药物成分外渗于角结膜面及筋膜组织，避免药物通过结膜血管及淋巴管进步血压循环，降低全身副作用的风险，减少毒性及不良反应的发生。

換気のためのデバイスおよび関連する方法

Resumen de: US2024091483A1

Provided herein are devices and methods that relate to ventilation and respiration. In one embodiment, a ventilator device comprising a fluidic amplifier with one or more coaxially aligned components, where there are no internal moving components. In another embodiment, a device and related methods for treating a patient who needs ventilation such as after infection by the coronavirus Covid-19.

一种可降解材料及其制备方法和用途

Resumen de: CN120960503A

本发明公开了一种可降解材料及其制备方法和用途。所述可降解材料,包括脂肪族聚酯和/或改性脂肪族聚酯，所述可降解材料为薄片状，其厚度为0.1‑8mm，优选为2‑5mm。本发明制备的可降解(面部填充塑形)材料厚度可控并可根据实际需求加工成不同形状，质地柔软，形态轻薄，减少了因重力引起的移位和骨吸收；厚度仅0.1‑8mm厚，填充时异物感不明显，植入手术简便，耗时短；具有良好的组织整合性，术后稳固不易移位，不会形成凸起和肉芽，并且不会对人体产生危害。

一种带卫生消毒功能的3D打印一次性碗盘装置及方法

Resumen de: CN120963029A

本发明公开了一种带卫生消毒功能的3D打印一次性碗盘装置及方法，旨在解决日常三餐洗碗的问题，同时确保餐具的卫生安全性。该装置包括3D打印模块、材料供给系统、成型平台、消毒模块及控制系统；所述方法通过预设模型选择、快速3D打印成型、紫外线+热风双重消毒的流程，实现一次性碗盘的即时制造与卫生保障。本发明采用食品级可降解材料，打印时间短（1‑3分钟/个），消毒后可直接使用，用完即弃且环保可降解，适用于家用、办公及户外场景，既省去洗碗步骤，又通过内置消毒环节提升餐具卫生等级。

一种混合支持式多角度可视化自适应正畸种植支抗导板的制备方法

Resumen de: CN120963041A

本发明公开了一种混合支持式多角度可视化自适应正畸种植支抗导板的制备方法，包括以下步骤：S1、数据采集；S2、数据拟合；S3、设计正畸种植钉；S4、设计混合支持式多角度可视化自适应正畸种植导板：获得牙冠‑牙根‑粘膜模型，设计牙齿‑粘膜‑咬合三重混合支持式多角度可视化自适应种植导板，进一步生成混合支持式多角度可视化自适应正畸种植导板STL文件；S5、3D打印；S6、制成成品：将打印后的导板去除支撑杆、打磨抛光，消毒后，制作完成。本发明使导板抗旋位移力提升，术中无需额外器械固定；可视化轨道与头端开口全程暴露钻头与钉尖，方便导板脱位，医生可在直视下避开牙根、上颌窦及神经管，牙根损伤率降低。

一种具有光热介导形状记忆和热疗功能的大豆油基复合骨支架及其制备方法

Resumen de: CN120960519A

本发明公开了一种具有光热介导形状记忆和热疗功能的大豆油基复合骨支架及其制备方法。该方法以生物基丙烯酸化环氧大豆油和聚乙二醇二丙烯酸酯为复合基体，将天然黑色素纳米颗粒作为功能组分掺入其中制得复合光敏树脂，最终通过数字光处理3D打印技术制备成多孔支架。在近红外光的照射下，复合支架表现出可控的和高效的光热响应行为，能够通过调整天然黑色素纳米颗粒的负载量和照射条件来达到目标的稳态温度。一方面，光热效应能够触发形状记忆恢复，以实现对不规则骨缺损的微创植入与形状自适应填充。另一方面，复合支架表现出对人骨肉瘤细胞高效的光热抑制效应（抑制率超过90%）。此外，复合支架表现出增强的体外生物矿化能力。本发明为设计和制备多功能生物基3D打印骨支架以应对复杂骨缺损的挑战提供了一个有前景的解决方案。

一种利用低温3D打印技术制备多孔丝素蛋白骨水泥支架的方法

Resumen de: CN120960511A

本发明公开了一种利用低温3D打印技术制备多孔丝素蛋白骨水泥支架的方法，属于生物医用材料技术领域。该方法包括采用同轴喷头，将包含丝素蛋白、海藻酸盐及生物活性陶瓷的壳层墨水与牺牲性芯层墨水，共同挤出至温度呈梯度分布的低温平台；将形成的冷冻核‑壳结构丝束进行冷冻干燥后，浸入钙离子溶液中，以同步实现牺牲性芯层的洗脱移除来构筑中孔，以及海藻酸盐的离子交联来增强结构；最后通过温和的乙醇蒸汽处理完成最终固化。本发明可构筑兼具大孔、中孔及梯度微孔的三级仿生孔道结构，且制备的支架具有优异的结构可控性和力学性能。

一种基于3D打印的功能化胶原支架及其在跟腱修复与异位骨化预防中的应用

Resumen de: CN120960505A

本发明涉及生物医学工程与组织再生技术领域，具体公开了一种基于3D打印的功能化胶原支架及其在跟腱修复与异位骨化预防中的应用，所述支架是结合聚乳酸‑羟基乙酸共聚物与Ⅰ型胶原的复合基材，集成经BMP抑制剂预处理及胶原结合肽修饰的CD26+肌腱干细胞外泌体，形成的3D打印支架。本发明通过集成BMP信号抑制与胶原靶向缓释双功能策略，结合3D打印技术制备的复合支架，显著解决了现有肌腱修复技术中再生效果不足与异位骨化(HO)高发的难题。

一种基于中医治疗的护心灸制备工艺及其使用方法

Resumen de: CN120960041A

本发明公开了一种基于中医治疗的护心灸制备工艺及其使用方法，具体涉及护心灸技术领域，包括步骤如下：S1、药物配方研制，S2、灸具设计，使用方法包括步骤如下：S1、精准穴位定位，S2、灸疗方案制定，S3、优化灸疗过程。本发明通过现代技术优化药物配方与剂型提升疗效，创新灸具设计保障安全舒适，借助先进手段实现精准个性化治疗，综合管理系统协同各模块为优化治疗和工艺改进提供支持，带来更优质中医治疗体验。

用于弧形3D物品的旋转立体光刻

Resumen de: US2024351282A1

A three-dimensional (3D) printing system is configured to manufacture a plurality of arcuate 3D articles. The 3D printing system includes a build vessel, at least one build assembly, a light engine, and a controller. The at least one build assembly individually includes an axle, a build plate, and a motorized gear assembly. The motorized gear assembly is coupled to the axle and configured to rotationally position the axle about an axis of rotation. The light engine is located above the build vessel. The controller is configured to operate the motorized gear assembly to incrementally rotate the build plates about the axis of rotation between a plurality of stop positions. The controller is configured to operate the light engine at individual stop positions to selectively irradiate the photocurable liquid within a plurality of spatially separated build planes that are individually above one of the plurality of build plates.

AUTOMATIC DETECTION OF DENTAL INDICATIONS

Resumen de: JP2023153040A

To provide a method of identifying an indication of a digital dental object based on a geometric shape so that a suitable manufacturing method can be selected.SOLUTION: A dental recognition method using a manufacturing device (200) is provided, comprising providing a digital dental object in a coordinate system describing a shape of a dental object to be manufactured (S101), and automatically assigning the digital dental object to a predetermined class based on the shape using a self-learning algorithm (S102).SELECTED DRAWING: Figure 6

3D-gedruckte Orthese und Herstellungsverfahren hierfür

Nº publicación: AT528258A1 15/11/2025

Solicitante:

TURN MOTION FLEXCO [AT]
Turn-Motion FlexCo

Resumen de: AT528258A1

Die Erfindung betrifft ein Verfahren zum Herstellen einer Orthese (21), gekennzeichnet durch die Schritte: - Bereitstellen eines Multiachsen 3D-Druckers zum Drucken einer Endlosfaser (30), - Drucken eines ersten Stützabschnitts (22) der Orthese (21), wobei die Endlosfaser (30) in gekrümmten Flächen (F1, F2) und/oder in einem Winkel zueinander angeordneten ebenen Flächen gedruckt wird. Die Erfindung betrifft weiters eine mit diesem Verfahren hergestellte Orthese und ein computerimplementiertes Verfahren zur Ermittlung von Ansteuerbefehlen für einen 3D- Drucker zum 3D-Drucken dieser Orthese.