Alerta

一种载姜黄素3D生物打印墨水及其制备方法与应用

Resumen de: CN120393112A

本发明公开了一种载姜黄素3D生物打印墨水及其制备方法与应用，属于3D生物打印材料技术领域。该制备方法具体包括以下步骤：(1)包载物的制备；(2)姜黄素纳米粒子溶液的制备；(3)载姜黄素3D生物打印墨水的制备。本发明采用物理混合的方法将姜黄素纳米粒子溶液和高分子粉末混合，由此制得的载姜黄素3D生物打印墨水具有显著的抗炎活性和较好的促进伤口愈合效果，同时具有较好的可打印性和ROS响应释放特性，可用于载药医疗器械，对提高姜黄素的给药精确性具有重要意义。而且，本发明制备方法操作简单，效果显著，应用范围广，能拓宽载姜黄素3D生物打印墨水的应用范围，具有良好的应用前景。

一种牙模3D打印控制系统

Resumen de: CN120396331A

本发明提供了一种牙模3D打印控制系统，包括：LCD屏幕、用于发射紫外光的UV光源、用于附着已固化模型的成型平台、盛放液态陶瓷填充光敏树脂的料槽、墨盒、带动成型平台与墨盒移动的Z轴和X轴电机、丝杠以及传感器。所述墨盒外部配备磁铁结构，可紧密吸附在料槽的钢板上；磁铁外围集成刮刀组件，使得墨盒在运动过程中能够同时对浆料进行均匀刮平；墨盒顶部配备墨盒盖。本系统不仅优化了料槽设计，还配备了自动供料墨盒，以在打印过程中动态补充浆料，同时利用墨盒中的刮刀组件确保浆料均匀分布，优化固化质量。这种设计有效避免了传统光固化3D打印机因浆料供给不足或分布不均而导致的打印缺陷。

一种3D打印肝癌切除手术导板的制造方法

Resumen de: CN120392288A

本发明涉及医学领域，且公开了一种3D打印肝癌切除手术导板的制造方法，包括以下步骤：CT数据采集：进行肝脏增强扫描，获取多期DICOM格式数据；应用3D可视化软件，以门静脉4级分支流域为基础，规划肝脏切除范围并确定手术切面；应用3‑matic Medical等工程软件，基于手术切面设计肝脏表面及实质内手术导板；使用3D打印机将数字手术导板打印为实物模型，用于手术定位与导航。传统的肝癌手术规划建立在标准的肝脏分段方法之上，缺乏个性化。目前主要应用肝蒂阻断法及染料注射法进行手术路径导航，存在操作复杂、成功率低、重复性差等问题。本发明为一种3D打印肝癌切除手术导板的制造方法，通过3D数字技术实现手术科学规划与精确导航。通过本技术方法提高手术的根治性与安全性，增进肝癌治疗效果。

用于制造金属嵌入式医疗植入物和装置的三维打印方法

Resumen de: WO2024093647A1

Three-dimensional (3D) printing methods for making metal-embedded medical implants and devices are provided. The newly developed 3D printing technology and surface modification method will contribute to the wider application of 3D-printed patient-specific products in many medical fields showing excellent clinical safety.

含图案的液体及其制造方法

Resumen de: AU2023419073A1

The purpose of the present invention is to provide: a liquid with a pattern, said liquid including a pattern that can produce, in a liquid matrix, a sensation such as a color, a flavor, a texture, or a tactile sensation, said pattern having good stability; and a method for producing a liquid with a pattern which makes it possible to stably form a pattern in a liquid matrix. The present invention relates to, for example, a liquid with a pattern, said liquid including, in a liquid matrix, a pattern formed by microparticles and/or a pigment, wherein the liquid matrix is pseudoplastic fluid and is accommodated in a container.

一种用于口腔修复材料的3D打印辅助设计系统

Resumen de: CN120392358A

本发明涉及三维模型设计技术领域，且公开了一种用于口腔修复材料的3D打印辅助设计系统，包括数据采集模块、初始模型设计模块、设计优化模块以及结果输出模块；通过设有初始模型设计模块与设计优化模块，有利于基于构建个体的口腔模型，从牙型数据库中选取与个体匹配度最高的修复体模型作为初始模型，基于改进后的优化算法获取最优调整参数，根据最优调整参数对初始模型的修复体设计参数进行调整优化，获取优化后的修复体模型；通过精确的数据对修复材料进行智能优化设计，结合人体的牙型数据库与患者的个体数据，进行个性化的修复材料设计的优化，进而同时保证牙齿外形的美观性与实用性。

基于柔性糖牺牲载体的可注射中空支架及其制备方法

Resumen de: CN120393118A

本发明涉及一种基于柔性糖牺牲载体的可注射中空支架及其制备方法，将蔗糖、果糖、葡聚糖、葡萄糖混合溶解到蒸馏水中，高温持续搅拌得到粘稠溶液，高温交联得到糖打印材料；利用糖打印材料在平面内打印柔性糖网平面基材，为软质柔性可形变状态；对柔性糖网平面基材进行塑形，得到柔性糖牺牲载体，将PCL涂层液多层涂覆到柔性糖牺牲载体，得到双层支架；置于蒸馏水中溶解柔性糖牺牲载体，得到可注射中空支架。本发明通过精确控制柔性糖牺牲载体中各组分的比例，令其性状可一段时间内维持软质柔性可形变状态，仅需要在二维平面内打印出基材，然后塑型处理，实现对特定器官形态的模拟，提高了复杂器官重建的准确性和可行性。

3D打印多孔金属-陶瓷组配式复合植入体及其制备方法和应用

Resumen de: CN120392380A

本发明涉及一种3D打印多孔金属‑陶瓷组配式复合植入体及其制备方法和应用。3D打印多孔金属‑陶瓷组配式复合植入体:包括由3D打印一体式多孔金属模块和3D打印一体式多孔陶瓷模块复合在一起的多孔金属‑陶瓷植入体本体、包置于多孔金属‑陶瓷植入体本体外周的网状金属保护体一起形成的能够与缺损部位骨组织的外形和结合面精准匹配的组配式复合植入体。发明所述复合植入体，具有成骨环境调控功能化，能达到即时恢复缺损骨组织的运动功能，改善骨缺损部位组织微环境，加速新骨再生并引导新骨向多孔金属植入物内部生长，实现骨/金属植入物界面的快速骨整合，以及陶瓷降解后3D打印多孔金属植入物/自体骨融合式修复的远期治疗效果。

用于制造正畸器具的包含可聚合反应性稀释剂的可固化组合物

Resumen de: US2024191006A1

The present disclosure provides curable compositions comprising one or more of photo-polymerizable monomers as reactive diluents, as well as polymeric materials formed from the curable compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

一种3D打印微针及其制备方法和其应用

Resumen de: CN120392633A

本发明涉及一种3D打印抗菌微针，所述微针为由载药针尖层、针体层、载药储库层和基底层制成的多层仿生蘑菇状结构，其中，载药针尖层：针体层：载药储库层：基底层的体积比为1:1:20‑50:20‑50；载药针尖层采用可溶性聚乙烯吡咯烷酮负载纳米复合体后制得；针体层由甲基丙烯酰化聚赖氨酸和甲基丙烯酰化透明质酸钠浓缩后光共交联后制得；载药储库层由采用可溶性聚乙烯吡咯烷酮负载纳米复合体后制得；基底层由不可降解的聚乙二醇二丙烯酸酯光交联后制成。本发明采用3D打印联合聚二甲基硅氧烷翻模法一体化制备微针，所述微针具有优异的机械性能和穿刺性能，利于在创伤部位实现自主给药，实现药物的精准释放、高效摄取及“组织渗透‑细菌靶向‑基因沉默”的级联效应，显著缩短创面愈合时间，显著提高抗菌药物的靶向递送效率、生物利用度和安全有效性，攻克核酸药物难以用于抗创面感染的问题。

一种用于皮肤及毛囊再生的预制化生物3D打印人工皮肤制备方法

Resumen de: CN120393113A

本发明提供一种用于皮肤及毛囊再生的预制化生物3D打印人工皮肤制备方法，主要包含GelMA、HAMA和皮肤干细胞。生物3D打印人工皮肤的制备方法是首先配置每毫升含50毫克GelMA和5毫克HAMA的水凝胶溶液，再加入107‑108个皮肤干细胞，真皮干细胞和表皮干细胞比例为1:2。最后，将细胞与水凝胶混合也转入注射器冷藏3分钟后移入生物3D打印机中，按预设打印参数制备不同模型的人工皮肤。本发明所优化的水凝胶材料具有优良的可打印性，较低的溶解度和溶胀率以及稳定的力学性能。本发明采用的水凝胶材料能够与皮肤干细胞配合促进皮肤干细胞的干性提高，更利于皮肤的修复与毛囊的再生。本发明制备的生物3D打印人工皮肤可立即或体外培养后用于伤口中促进皮肤及毛囊。

椎间融合器用近红外3D打印硅橡胶复合材料及其制备方法

Resumen de: CN120393108A

本发明公开了椎间融合器用近红外3D打印硅橡胶复合材料及其制备方法，将YbCl3·6H2O与TmCl3·6H2O/ErCl3·6H2O/PrCl3·6H2O按摩尔比(Tm:Er＝1:0.2～0.5或Tm:Er:Pr＝1:0.2～0.5:0.1～0.3)溶于水，与EDTA‑2Na、NaF、AgNO3反应制得NaYbF4:M/Ag；再经SiO2包覆和CTAB/硅烷改性获得硅烷改性NaYbF4:M@SiO2复合粒子；再将其与热/光固化硅橡胶单体、引发剂及羟基磷灰石混合制得近红外光‑热协同固化硅橡胶墨水。该材料可实现高精度3D打印，兼具良好生物相容性和力学性能，适用于椎间融合器医疗硅橡胶制品的制备。

一种体外调节的单向滑动生长棒

Resumen de: CN120392262A

本发明涉及骨科医疗器械技术领域，具体涉及一种体外调节的单向滑动生长棒，包括：近端套筒、远端套筒、卡扣部件、弹簧驱动部件以及可拆卸预弯棒，远端套筒的内筒壁开设有直线滑槽，近端套筒外壁形成直线滑条，近端套筒的一部分套接在远端套筒的内筒内部，远端套筒的内筒设有所述弹簧驱动部件，远端套筒的外壁安装有卡扣部件，滑动生长棒两端分别连接有可拆卸预弯棒，卡扣部件内包括卡扣外壳、限位部件和单向滑动部件；本发明能够提高生长棒的性能。

Spinal Implant With Porous And Solid Surfaces

Resumen de: US2025241766A1

A spinal implant including porous and solid portions is disclosed. The implant includes porous portions on upper and lower surfaces and in an interior thereof. Methods of manufacturing and implanting such implants are also disclosed.

FEATURES FOR IMPLANTS WITH A REDUCED VOLUMETRIC DENSITY OF SURFACE ROUGHNESS

Resumen de: US2025241765A1

The invention disclosed herein includes implant features that can be used, in some embodiments, on devices with a volumetric density of less than about 100 percent and devices with a surface roughness of some value. The implant features include one or more protrusions mounted on the forward edge of an implant that can ease the distraction of tissue during implantation and reduce the occurrence of damage during a manufacturing process. In some embodiments, the protrusions have gaps in a non-axial direction with respect to the implant to allow axial compression with respect to the protrusions. In some embodiments, the protrusions have a circumferential gap between them and a body of a device to reduce any impact on the device's elastic modulus.

SYSTEM AND METHOD FOR GLAZING DENTAL RESTORATIONS WITH CERAMIC INK VIA INKJET PRINTER

Resumen de: US2025241734A1

Disclosed are systems and methods of a decision intelligence (DI)-based computerized framework that automatically and/or dynamically implements a color algorithm for performing staining and glazing dental restorations. The framework operates by leveraging determined color variations through AI/ML-based analysis that generate detailed color maps, which can be translated into precise printing instructions controlling the mixture and layering of dental-grade glazing materials. A printing system can employ multiple print heads with varying base colors and opacity levels to create microscopic color gradients and translucency effects matching natural tooth enamel. The disclosed automated processing applies personalized color patterns in microscopically thin layers, ensuring consistent glaze thickness while replicating regional variations across the tooth surface. Such approach eliminates manual glazing variability while achieving superior customization compared to traditional pre-set patterns, resulting in dental restorations that integrate seamlessly with existing teeth.

SYSTEM AND METHOD FOR CERAMIC INKJET MESH PRINTING

Resumen de: US2025241735A1

Disclosed are systems and methods for a computerized framework for automated ceramic inkjet printing in dental restoration manufacturing. The disclosed ceramic inkjet mesh printing for dental restorations combines precision digital control with ceramic materials to create highly accurate and aesthetically pleasing dental prosthetics. The disclosed mechanisms utilize specialized printheads designed to deposit precise amounts of ceramic materials onto dental substrates, enabling the creation of detailed color gradients and natural-looking surfaces that closely mimic natural teeth.

MINIMALLY INVASIVE AND ENDOSCOPIC IN-VIVO BIOPRINTING SYSTEMS AND METHODS

Resumen de: US2025242171A1

A system may include a donor supply sub-system configured to supply donor material to a donor substrate. The system may include a material transfer sub-system comprising a laser configured to illuminate the donor substrate via a transfer beam. The system may include an instrument head of a medical instrument configured to house the donor substrate, wherein upon an illumination of the donor substrate, the donor material is transferred to receiver material in vivo.

3D BIOPRINTED HYDROGEL MICROFLUIDIC SYSTEMS AND PERFUSION BIOREACTORS FOR ENGINEERING VASCULARIZED TISSUE CONSTRUCTS

Resumen de: WO2025160474A1

3D bioprinted hydrogel microfluidic systems and perfusion bioreactors for engineering vascularized tissue constructs are provided. An example of an internally perfusable scaffold comprises an exterior surface, a body, a first port, and an interior wall. The first port comprises a first coupling feature configured to engage a fitting and form a fluid tight seal therewith. The first interior wall defines a fluid cavity extending into the body from the first port. The scaffold comprises a hydrogel.

3D-PRINTED, WELL PLATE-INTEGRATED PIEZOELECTRIC CANTILEVER SENSORS FOR CELL CULTURE MONITORING

Resumen de: US2025243447A1

A hybrid microextrusion pick-and-place 3D printing process enables fabrication of 3D-printed well plate-integrated piezoelectric cantilever sensors for monitoring properties and composition of tissue culture models. 3D-printed piezoelectric cantilever sensors exhibit multiple resonant modes across the 1-150 kHz frequency range. The ability to control cantilever frequency response (i.e., mode locations and types) was demonstrated by variation in the 3D-printed anchor geometry through corresponding changes in tool path and microextrusion process parameters. 3D-printed piezoelectric cantilever sensors facilitated in situ monitoring of cell culture media density and viscosity. This work presents an advance in the fabrication of cantilever sensors through the use of hybrid 3D-printing and pick-and-place processes that improves sensor reproducibility and enables novel control over anchoring of piezoelectric components and sensor integration with both 2D and 3D cell culture models, particularly 3D-bioprinted tissue constructs and microphysiological systems.

METHOD AND SYSTEM FOR MERGING BIO-ELECTROSPRAYING, CELL ELECTROSPINNING MERGED WITH 3D MULTIMATERIAL MICROFLUIDIC BIOPRINTING FABRICATE HUMAN TISSUES FOR DRUG DISCOVERY APPLICATIONS

Resumen de: US2025243452A1

The present invention provides a method and system for fabricating complex human tissues by integrating bio-electrospraying, cell electrospinning merged with 3D multi material microfluidic bioprinting, and future additions of magnetic and acoustic levitation technologies. The fabricated tissues serve as an alternative to animal testing in drug discovery processes, aiding in the prediction of human physiological responses to various drug compounds.

METHODS OF PRODUCING MULTI-LAYERED TUBULAR TISSUE CONSTRUCTS

Resumen de: US2025243465A1

Described are methods for producing multi-layered tubular tissue structures, tissue structures produced by the methods, and their use.

CERAMIC DEVICES AND METHODS OF MAKING AND USING THE SAME

Resumen de: US2025243128A1

The present invention relates to methods for preparing ceramic devices having a surface that has been activated to enhance properties including strength, porosity, and bioactivity. Activation may include forming a gel layer on the surface of a ceramic device using an alkali solution and modifying the surface using a modifying material. The invention further relates to ceramic devices prepared by the methods and methods of using the devices.

System and method for producing pharmaceutical objects via 3D printing

Resumen de: AU2025205378A1

21894047_1 (GHMatters) P119307.AU.2 The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- ing. The system comprises a 3D printing machine (2) with a me-5 chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3) and a base system (4) carrying a print base (6) for receiving a prepared mixture (27) applied by the print head (5). The system comprises at least one carrier (35) for 10 holding a cartridge (28).Printing can be done on formatted print locations (49) on the base (6). The invention further relates to a method for producing pharmaceutical objects, comprising the steps of providing at least one pharmaceutical substance in at least one cartridge, placing the cartridge in a carrier, estab-15 lishing a fluid connection between a cartridge and a print head, such that the pharmaceutical substance may leave the print head through the print head nozzle, moving the print head nozzle ac- cording to a 3D print program and dispensing the pharmaceutical substance to a print base. 20 (Fig. 24) The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- 5 ing. The system comprises a 3D printing machine (2) with a me- chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3)

NOVEL POLYMER

Resumen de: US2025242078A1

The present invention relates to a functionalised polymer, methods of preparing the functionalised polymer, and compositions comprising the functionalised polymer. The present invention also relates to methods of using the functionalised polymer including for forming a polymer composition comprising cells from a tissue sample and for cell therapy.

BIOPRINTED SOFT TISSUE REINFORCEMENT SCAFFOLD

Resumen de: CN119968177A

The present disclosure encompasses systems, compositions, and methods for use in vivo, including for enhancing soft tissue in an individual. The systems, compositions, and methods may utilize a three-dimensionally printed scaffold comprising at least a polymeric scaffold and an extracellular matrix component, including an extracellular matrix component contained on the scaffold. The polymer scaffold may include specific unit cell structures having a specific design and a pattern of alternating configurations of unit cell structures.

SYSTEMS, APPARATUSES, AND METHODS FOR CREATING TISSUE INTERFACES

Resumen de: WO2024062324A1

A system for creating a tissue interface. The system includes a scanner, at least one processor, and a memory. The scanner is configured to scan a tissue site and generate a signal corresponding to a topography of the tissue site. The at least one processor is configured to receive the signal corresponding to the topography of the tissue site and to receive user input at a user interface identifying a therapy to be applied at the tissue site. The memory is coupled to the at least one processor and is configured to store instructions that when executed by the at least one processor in response to receiving the signal corresponding to the topography of the tissue site cause the system to transform the signal corresponding to the topography of the tissue site into a model site surface and generate a model tissue interface.

GUIDE PLATE FOR THE ANATOMICAL REALIGNMENT OF BONE FRACTURES

Resumen de: WO2024062369A1

Guide plate for the anatomical realignment of a plurality of fractured bone portions, comprising a back surface configured such as it can be distinctively coupled to the surface anatomy of the area of said plurality of fractured bone portions and characterized by a first plurality of holes placed on a first portion of the guide plate and a second plurality of holes placed on a second portion of the guide plate, wherein the first plurality of holes is misaligned with respect to the second plurality of holes.

CELL MACROENCAPSULATION DEVICES, METHOD OF FABRICATION AND USE THEREOF

Resumen de: WO2024059942A1

It is provided a cell macroencapsulation device for implanting cells in a recipient comprising cells encapsulated in a porous membrane, wherein the porous membrane consists of a sugar network coated with a polymeric solution comprising porogen, which can be used as a graft to transplant islets while protecting the graft from the immune system as well as providing enhanced convection and diffusion to ensure long-term cell survival and physiological insulin delivery.

MODULAR BUILD PLATFORMS FOR ADDITIVE MANUFACTURING

Resumen de: US2024100775A1

Systems, methods, and devices for additive manufacturing are provided. In some embodiments, a method includes: coupling a plurality of build platforms to a carrier; forming a plurality of 3D objects on the plurality of build platforms using an additive manufacturing process, where each build platform receives at least one 3D object thereon; removing the plurality of build platforms from the carrier; performing post-processing of the plurality of 3D objects while the 3D objects remain on the respective build platforms; and separating the plurality of 3D objects from the respective build platforms.

THIOL-ENE HYDROGEL

Resumen de: CN119997989A

A hydrogel string for encapsulating a biological material is provided. A hydrogel string has a thiol-ene cross-linked polymer having a first side chain functionalized backbone polymer functionalized with an activated olefin that is cross-linked with a free or protected thiol-containing group present on a second side chain functionalized backbone polymer. The biological material is encapsulated in a thiol-ene cross-linked polymer.

骨骼细胞提取羟基磷灰石制备3D打印油墨的方法

Resumen de: CN120383773A

本发明公开了一种骨骼来源羟基磷灰石制备3D打印油墨的方法，通过骨骼预处理、脱细胞、纳米化及复合油墨配制技术，实现天然HA的高效提取与打印应用，兼具环保性、情感价值及艺术创新。

一种软硅胶-硬塑料构成的包覆结构胆道支架及制造方法

Resumen de: CN120381355A

本发明公开了一种软硅胶‑硬塑料构成的包覆结构胆道支架，本发明包括防腐蚀内层、硬塑料内芯和包覆式生物相容性外层，防腐蚀内层为管状；硬塑料内芯包括若干个力学支撑结构环，各个力学支撑结构环沿胆道支架的轴向方向依次间隔固定套装在防腐蚀内层的外侧面，包覆式生物相容性外层包括若干个包覆式硅胶件，每个力学支撑结构环的外表面包覆有一个包覆式硅胶件，且每个包覆式硅胶件均一体成型于防腐蚀内层上。本发明可以提供与原生胆道相匹配的力学特性与生物相容性，能够并降低对胆道黏膜的刺激，承受胆汁腐蚀、减少细菌粘附、可长时间使用以及可以弯曲扭转以满足人体正常生理活动需求。

一种牙槽骨骨增量屏障膜及其制备方法

Resumen de: CN120381561A

本发明涉及医疗器械技术领域，尤其是涉及一种牙槽骨骨增量屏障膜及其制备方法。本发明提供的牙槽骨骨增量屏障膜包括通过3D打印技术制得的氧化锆膜；所述牙槽骨骨增量屏障膜包括牙槽嵴面、唇侧面和舌侧面，所述唇侧面和所述舌侧面位于所述牙槽嵴面相对的两侧；所述唇侧面和/或所述舌侧面上设置有固定孔，所述固定孔的总个数为至少两个；所述牙槽嵴面上设置有透气孔。本发明的牙槽骨骨增量屏障膜具有优异的机械性能和生物相容性，组织粘黏性低；能够更好的贴合患者牙槽骨缺陷处。

一种生物3D打印培养一体化设备

Resumen de: CN120382643A

本发明属于生物3D打印技术领域，具体的说是一种生物3D打印培养一体化设备，包括：机体，所述机体内壁的顶部滑动连接有密封板，所述机体的内壁均匀设置有导杆，所述机体的内壁靠近密封板的一侧滑动连接有挡板；承托机构，所述承托机构安装在机体内壁的底部，所述承托机构的内壁与导杆的外壁相套接；注入机构，所述注入机构安装在机体内壁的上方，本发明通过设置承托机构，使夹持组件将培养皿固定在承载板的中轴处，并使夹持组件与对齐组件调整注射头的位置，随后进行注射，使打印与培养处于一个机体内完成，避免在注射完成后还需要人工移动培养皿，使细胞的环境发生变化导致难以培养，同时确保在培养过程中使用者可以拆卸注射机构进行清洗。

METHOD FOR ARRANGING SUPPORTING STRUCTURES FOR THE ADDITIVE MANUFACTURING OF A DENTAL RESTORATION

Resumen de: US2024025122A1

A method for arranging support structures for an additive manufacturing process on a dental restoration, comprising the steps of detecting (S101) a flash line in a digital model of the dental restoration; and adding (S102) support structures to the digital model for supporting the dental restoration in the additive manufacturing process along the flash line.

硬化性組成物とその硬化物

Resumen de: US2025206865A1

A curable composition which has high curability and high transparency, while exhibiting good adhesion to various base materials, and which is used in both an aqueous system and an organic system and is applied to UV curing and/or thermal curing; a coating agent composition, a bonding agent composition, an adhesive composition, an ink composition, an aqueous ink composition, an ink composition for three-dimensional modeling, an aqueous coating material composition, a sealing agent composition, a nail cosmetic composition, a dental material and a decorative coating agent, each of which contains this curable composition; and cured products and molded articles of these materials. A curable composition contains: (A) a water-insoluble multifunctional (meth)acrylamide; and (B) a polymerizable compound other than the component (A).

生体関連材料を含む３Ｄバイオプリンティング、及び関連する方法

Resumen de: WO2024015237A1

The present disclosure provides a method of bioprinting a 3-D structure comprising one or more biologically-relevant materials on a super-hydrophobic surface. In one embodiment, the method comprises providing a composition having one or more biologically-relevant materials dispersed within a biocompatible medium. A pattern comprising a hydrophilic material is deposited on a defined area of the super-hydrophobic surface, wherein the pattern is modeled after a biological structure. The composition having the one or more biologically-relevant materials is then bioprinted atop the hydrophilic surface to form a 3-D structure, wherein the hydrophilic surface maintains the 3-D structure in a desired position or shape on the super-hydrophobic surface.

縫合可能な可撓性材料に用いるための相互侵入高分子網目構造

Resumen de: CN119894981A

An advanced fabricated interpenetrating polymer network (AM-IPN) is disclosed, comprising: a primary polymer network; a secondary polymer network, where the secondary polymer network is bound to the primary polymer network by one or more cross-links, where one or more of the primary polymer network, the secondary polymer network, and the one or more cross-links are printed using a synthetic bio-ink. Methods of making and using are also disclosed.

多功能牙科装置及相关方法

Resumen de: WO2023222193A1

The invention relates to a series (100) of devices for incrementally modifying the position of the teeth in a person (P), said series comprising at least two devices (10), the devices (10) each comprising at least one jaw device (11, 12), the at least one jaw device (11, 12) being designed in such a way that receiving regions of the jaw device (11, 12) can be placed on a dental arch of the upper jaw (OK, 5) or of the lower jaw (UK, 4) of the person (P), the devices (10) being designed such that, when worn according to a predefined order of said devices (10), they incrementally progressively modify the position of the teeth owing to mechanical interaction between the device and at least one tooth element. The at least one jaw device (11, 12) of the first device (10.1, 10.2) may carry, on its outer side, a first veneering element (N.I.1.2, N.IV.1.2) as a partial region of the first device (10.1, 10.2). The at least one jaw device (11, 12) of the second device (10. n) may carry, on its outer side, a second veneering element (N.I.1.n, N.IV.1.n) as a partial region of the second device (10). The first veneering element (N.I.1.2, N.IV.1.2) may be located at the same position as the second veneering element (N.I.1.n, N.IV.1.n) according to a dental notation. A receiving region of the first veneering element (N.I.1.2, N.IV.1.2) may have a different design and/or position than a receiving element of the second veneering element (N.I.1.n, N.IV.1.n), this difference being capable of cau

用于制造生物打印纤维结构的系统和方法

Resumen de: MX2024014120A

Aspects of the disclosure include a fabrication platform for supporting a bioprinted fiber structures during printing, patterning, and/or processing, comprising a frame with a plurality of posts for securing a cross-linkable fiber during printing thereof, and where a continuous length of the cross-linkable fiber is printed around a plurality of posts during the 3D bioprinting process. The fabrication platform enables the cross-linkable fiber to be suspended during one or more of printing, patterning, and/or processing. In this way, the bioprinted fiber structure comprises a uniform outer surface, and can be easily modified and/or further processed after printing and patterning are completed.

一种基于数字化技术的治疗义齿制作方法

Resumen de: CN120360726A

本发明公开了一种基于数字化技术的治疗义齿制作方法，其包括：通过扫描获取患者的口腔数据及颌位关系，根据扫描获得的口腔数据及颌位关系设计上颌义齿和下颌义齿；通过3D打印制成上颌基托实体、上颌牙列实体、下颌基托实体和下颌前牙实体；用粘接剂将上颌牙列实体粘接在上颌基托实体上形成上颌义齿实体，用粘接剂将下颌前牙实体粘接在下颌基托实体上形成下颌义齿实体；向下颌基托实体上的凹槽中填充材料形成树脂平板；对树脂平板进行修正，直至上颌义齿实体与下颌义齿实体建立正确的咬合关系。本发明采用数字化设计与3D打印相结合的方式，制作流程短，能显著缩短治疗义齿的制作周期；且制成的治疗义齿实体和所设计的数字化治疗义齿的一致性高，减少了认为误差。

一种蛋白纳米纤维复合类血管及其制备方法与应用

Resumen de: CN120361299A

本发明公开了一种蛋白纳米纤维复合类血管及其制备方法与应用，属于3D打印类血管结构技术领域。本发明首先通过AF和GelMA的氢键相互作用，构建了含有纳米蛋白纤维的凝胶墨水，然后通过嵌入式3D打印方法，利用AF和HA的正负离子相互作用和基质相中引发剂向墨水相中的渗透作用，经过紫外光化学交联和后处理，构建了微观尺度上含有纳米蛋白纤维，宏观尺度上壁厚可调的类血管结构。该类血管结构微观尺度上可模拟细胞外基质微环境的纳米纤维结构，宏观尺度上可模拟人体不同部位血管的壁厚，为体外构建血管样结构提供了一种新策略。

一种双相生物活性组织修复支架及制备方法

Resumen de: CN120365051A

本发明公开了一种双相生物活性组织修复支架及制备方法，包括以下步骤：步骤1：磷酸钙陶瓷粉体进行表面改性，得到改性后的磷酸钙陶瓷粉体；步骤2：将改性后的磷酸钙陶瓷粉体、铌酸钾钠压电陶瓷粉体、分散剂、光引发剂、光敏树脂充分混合均匀，球磨后得到光固化树脂浆料；步骤3：按照设计构建3D打印模型，将光固化树脂浆料按照3D打印模型打印即可得到支架坯体；步骤4：支架坯体经清洗、脱脂烧结即可得到所需支架；本发明能够制备兼具良好的力学性能、高效抗肿瘤能力及较好的促骨再生能力的双相生物活性组织修复支架，为临床上骨肿瘤术后骨缺损的修复提供技术支持。

LINKAGE APPARATUS FOR PRINTER, PRINTER, AND MEDICAL APPARATUS

Resumen de: US2025235165A1

Embodiments of the present application provide a linkage apparatus for a printer, a printer, and a medical apparatus. The linkage apparatus comprises: a paper compartment assembly, provided with a side opening, a base, a paper tray located in the base, and a paper advancing member disposed opposite the side opening, an end of the paper advancing member opposite the side opening being provided with an advancing plate extending upward; a door assembly, movably connected to the paper compartment assembly and capable of closing or opening the side opening; and a transmission mechanism, one side of which is connected to the door assembly, the transmission mechanism driving the paper advancing member to move toward the side opening along with opening of the door assembly, causing the paper advancing member to, by means of the advancing plate, advance paper in the paper tray to move toward the door assembly.

DUAL CROSSLINKED SILK-BASED MATERIALS FOR IN SITU DEPOSITION OR PRINTING

Resumen de: WO2025155859A1

Disclosure herein concerns a non-crosslinked composition having capacity for double crosslinking. The non-crosslinked composition includes a population of methacrylate-modified silk fibroin fragments, each of the methacrylate-modified silk fibroin fragments comprising methacrylate side chains, a photo-crosslinker, an enzymatic crosslinker and optionally one or more enzymatic crosslinker co-reactants, and water

METHOD AND DEVICE FOR MANUFACTURING TRANSPARENT ORTHODONTIC DEVICE, AND RECORDING MEDIUM

Resumen de: WO2025155025A1

Disclosed are a method, a device performing the method, and a recording medium, the method comprising the steps of: obtaining, by a processor, specification information about a plurality of standard pre-aligners, which is generated on the basis of statistical information; obtaining, by a reception unit, oral information about a user; determining, by the processor, one of the plurality of standard pre-aligners on the basis of the oral information and the specification information; obtaining, by the processor, a tooth model corresponding to the oral information; and deforming, by the processor, the determined standard pre-aligner to correspond to the tooth model so as to obtain a transparent orthodontic device corresponding to the tooth model.

LIGHT THERAPY LOUNGER AND METHOD OF MANUFACTURING THEREOF

Resumen de: US2025235717A1

Embodiments of the present invention disclose a light therapy lounger. The light therapy lounger includes a frame including a peripheral wall and an inward protrusion extending internally from an inner surface of the peripheral wall. Further, the light therapy lounger includes a plurality of irradiation boards located on the inward protrusion and including a plurality of irradiation sources. Also, the light therapy lounger includes an upper cover made up of a diaphanous material, the upper cover configured to be located above the plurality of irradiation boards. Each irradiation board includes one or more pressure sensors and several irradiation sources electrically coupled to a first Printed Circuit Board (PCB), a heat sink thermally coupled to the first PCB and located under the first PCB, and a plurality of cooling fans electrically coupled to the first PCB and/or a second PCB, and located under the heat sink.

METHOD FOR PRODUCING CELL-BASED FISH CONTAINING FISH MUSCLE SHAPE-MIMICKING MUSCLE USING 3D BIOPRINTING TECHNOLOGY AND CELL-BASED FISH PREPARED THEREBY

Resumen de: US2025234907A1

Provided are a method for producing an edible cell-based fish that can realize actual fish muscle shape and texture, and a cell-based fish prepared thereby. The method for producing cell-based fish containing fish muscle shape-mimicking muscle using 3D bioprinting technology includes the steps of: mixing cells for cultured fish and an edible bioink; printing the cell printing ink in a fish muscle-mimic pattern to form a laminated structure; adding a crosslinking agent to the laminated structure; and culturing the laminated structure to which the crosslinking agent is added into a fish muscle tissue.

積層造形方法および積層造形方法によって製造された高圧チャンバー

Resumen de: MX2024014173A

Aspects of the present disclosure include methods for providing a site for the hyperbaric chamber, installing a deposition system at the site, wherein the deposition system is configured to deposit building materials for constructing the hyperbaric chamber, loading a layout of the hyperbaric chamber into the deposition system, and depositing the building materials according to the layout onto the site.

回転フレーム装置及び生体適合性足場構築物

Resumen de: CA3203473A1

A biocompatible scaffold construct includes a plurality of collagen fiber strands, a first portion of which have been coated by a first biocompatible solution and, optionally, a second portion of which have been coated by a second biocompatible solution different than the first biocompatible solution. The coatings may include cells. And the scaffold is constructed on rotating frame collectors.

SYSTEMS AND METHODS FOR MODIFYING SURFACES OF ADDITIVELY MANUFACTURED OBJECTS

Resumen de: US2024091906A1

Systems and methods for processing additively manufactured objects are described herein. In some embodiments, for example, a system includes a controller configured to provide one or more control signals; a heater coupled to the controller, where the heater comprises one or more heating elements arranged to heat a blasting medium in response to the one or more control signals; a chamber coupled to the controller, where the chamber comprises an agitatable drum shaped to receive a plurality of additively manufactured objects, and to agitate the plurality of additively manufactured objects in response to the one or more control signals; and an applicator coupled to the controller, where the applicator comprises a nozzle operative to direct, in response to the one or more control signals, a plurality of thermally conductive particles in the blasting medium toward the plurality of additively manufactured objects within the agitatable drum.

三维打印牙模

Resumen de: CN223126679U

本申请提供了一种三维打印牙模，包括：主体部，所述主体部的底部位于第一平面内，并且所述底部为开放式，所述主体部的内部具有容纳腔，所述主体部具有外壁；支撑部，位于所述容纳腔内，所述支撑部在所述第一平面上的投影为蜂窝状，并且所述支撑部具有沿垂直于所述第一平面的第一方向从所述底部延伸到所述外壁的支撑壁；其中，所述支撑壁在所述第一方向上至少部分的厚度小于所述外壁的厚度。

一种3D打印三叉神经痛球囊压迫穿刺导板

Resumen de: CN223126615U

本实用新型涉及医用辅助器械，一种3D打印三叉神经痛球囊压迫穿刺导板，包括导板本体和导向管；所述导向管与导板本体之间通过支撑悬臂连接，所述导向管为半圆管状。本实用新型采用半圆管形式的导向管，其在穿刺完成后，能够方便快速的与穿刺器械进行分离，穿刺完成无需再进行导向时，可以在不抽出穿刺器械的基础上实现导向管与穿刺器械的快速脱离，降低了穿刺导板本身造成的术野干扰和操作干扰。

生物墨水制造装置

Resumen de: WO2024128661A1

A bioink manufacturing device is provided. The bioink manufacturing device according to the invention includes: a reaction container for reacting a decellularized xenogeneic organ tissue with an inkification solution, a bioink liquefaction unit for stirring and crushing the decellularized xenogeneic organ tissue to liquefy same into bioink, and a bioink discharge unit for discharging the liquefied bioink outside of the reaction container.

一种骨科医用3D打印锌基球形粉末及制备方法

Resumen de: CN120347202A

本发明提供一种骨科医用3D打印锌基球形粉末及制备方法，属于金属粉末材料与制备技术领域，包括：制备符合成分要求的锌基金属熔体；将所述锌基金属熔体引流至高速旋转的圆盘中心，旋转加速后，分裂、成球、冷却、凝固，得到锌基球形粉末料；将所述锌基球形粉末料进行筛分，即得所述锌基球形粉末。通过选定锌基金属，并结合改进后的旋转圆盘，制备出高品质骨科医用3D打印锌基球形粉末，所制备出的3D打印锌基球形粉末空心粉率降低至1%以内，粉末球形度高，粉末粒径的D90与D10之差小于10µm，粉末利用率可达90%以上。

一种时空间声学超材料贴片及其制备方法与应用

Resumen de: CN120346464A

本发明公开了一种时空间声学超材料贴片及其制备方法与应用，包括自下而上依次设置的压电基底、聚焦声波换能器以及声学阻抗匹配层；所述的聚焦声波换能器为两对以上的叉指电极对，各叉指电极对能够通过交频信号各自激活并产生聚焦声场；所述的声学阻抗匹配层为通过光刻打印逐层光交联的微米尺度锥形结构阵列，能够实现声学传感器和组织的阻抗匹配。本发明利用多重叉指电极具有时空间聚焦超声能量的功能，而且声学阻抗匹配层可以更好的传递声波能量和装载各种治疗功能的活性物质，从而实现低温伤口的热、炎症、和愈合多重管理。这种基于声学超材料为基础的贴片具有多功能、数字化可控、精准治疗、方便可靠等优点。

基于人工智能的髓腔固位冠制造方法、系统

Resumen de: CN120326941A

本发明涉及牙冠制造技术领域，具体涉及基于人工智能的髓腔固位冠制造方法、系统，基于人工智能的髓腔固位冠制造方法包括：获取口腔CBCT影像与口扫模型；将口腔CBCT影像与口扫模型合成为合成模型；将合成模型输入训练后的AI模型，由AI模型基于合成模型生成髓腔固位冠模型；对髓腔固位冠模型做模拟受力测试，当髓腔固位冠模型的任意区域的应力大于预定值时，重新生成髓腔固位冠模型；对模拟受力测试合格的髓腔固位冠模型做模拟试戴测试；根据模拟试戴测试的结果调整髓腔固位冠模型；将调整后的髓腔固位冠模型输入打印装置并打印生成半成品髓腔固位冠；对半成品髓腔固位冠进行固化处理，生成成品髓腔固位冠。本申请提高了患者体验。

一种具有活性的骨缺损修复材料及其制备方法

Resumen de: CN120324678A

本发明公开了一种具有活性的骨缺损修复材料及其制备方法。所述骨缺损修复材料由动物来源提取的胶原蛋白、煅烧骨基质及骨形态发生蛋白复合微球复合，通过光固化3D打印技术成型制成。本发明从仿生角度出发，拟以胶原蛋白作为框架材料，以免疫原性低的煅烧骨基质作为硬质材料增强材料力学支持，并辅以骨形态发生蛋白复合微球协同作用，长效引导未分化间充质干细胞向特定方向发展。该活性骨缺损修复材料，植入骨缺损部位后，为细胞提供一个利于细胞粘附和增殖微观环境，同时骨形成发生蛋白的缓慢释放，能够长效作用于骨缺损部位，有效地推动成骨细胞分化成熟的过程，促进骨缺损部位的骨修复。

纳米羟基磷灰石/聚酰胺66复合材料的成型方法及应用

Resumen de: CN120326930A

本发明公开了纳米羟基磷灰石/聚酰胺66复合材料的成型方法及应用，其中，纳米羟基磷灰石/聚酰胺66复合材料的成型方法，包括：成型，采用熔融沉积成型的挤出式3D打印机对含纳米羟基磷灰石/聚酰胺66复合材料的料浆进行3D打印成型，得到打印件；后处理，对所述打印件依次进行干燥和退火，得到纳米羟基磷灰石/聚酰胺66复合材料的成型件。本申请利用3D打印可基于患者CT数据的三维重建技术可定制椎体假体形态，实现与复杂解剖结构的精确匹配，避免标准化椎体假体的局限性；还能够精确设计孔隙结构，而羟基磷灰石本身具备微观孔隙结构(<10μm)，从而使产品具备多级孔隙结构，有利于加速骨整合。

一种FARSs的数字化设计及制作方法及FARSs

Resumen de: CN120324131A

本发明公开了一种FARSs的数字化设计及制作方法及FARSs，该方法包括：获取使用者静态的上下颌牙列数字化三维模型、颌骨数字化三维模型及下颌动态运动数据，并在CAD/CAM软件内进行拟合，以构建使用者的动态VDP模型；基于使用者的动态VDP模型，确定使用者的治疗颌位，并导出对应于各治疗颌位的数字化三维牙列模型；依据所导出的各治疗颌位对应的数字化三维牙列模型，在CAD/CAM软件内中完成牙合面具有解剖形态的FARSs的个性化设计；根据个性化FARSs的设计数据，使用3D打印技术一次性完成FARSs的制造。本发明制作的FARSs通过全数字化流程制作，相比传统前伸再定位咬合板，个性化位置精度高，贴合性好，舒适度高，可以改善咀嚼功能；其次，序列治疗降低治疗难度、减少患者复诊次数。

3D打印金属植入物

Resumen de: CN223111858U

本实用新型公开了3D打印金属植入物，包括植入物主体。本实用新型通过采用了顶部件、中部件、底部件，作业时，通过3D打印机可以分批次的将顶部件、中部件以及底部件进行3D生产出来，接着将生产出来的多组部件可以通过底部的限位环与顶部的定位槽进行对接就可以实现多组结构的初步连接操作，接着转动结构可以使得孔洞相互对齐，然后在孔洞中安装上紧固螺栓，通过紧固螺栓就可以实现多组结构的固定操作，由于构成植入物主体的结构采用模块化的设置，因此在生产过程中容错率大幅度提升，可以在某一部件出现不合格时针对性的进行替换生产，不需要整个结构进行重新生产，有效的提升了整体的使用灵活性以及实用性，具有生产容错率高、使用灵活的优点。

LIQUID WITH PATTERN AND PRODUCTION METHOD FOR SAME

Resumen de: AU2023419073A1

The purpose of the present invention is to provide: a liquid with a pattern, said liquid including a pattern that can produce, in a liquid matrix, a sensation such as a color, a flavor, a texture, or a tactile sensation, said pattern having good stability; and a method for producing a liquid with a pattern which makes it possible to stably form a pattern in a liquid matrix. The present invention relates to, for example, a liquid with a pattern, said liquid including, in a liquid matrix, a pattern formed by microparticles and/or a pigment, wherein the liquid matrix is pseudoplastic fluid and is accommodated in a container.

3D PRINTED ARTIFICIAL BILE DUCTS AND MANUFACTURING METHOD THEREOF

Resumen de: US2025229006A1

The present invention relates to an artificial bile duct comprising ursodeoxycholic acid (UDCA), and due to comprising UDCA, the artificial bile duct of the present invention is effective in improving differentiation into cholangiocytes and preventing formation of bile stones.

AUTOMATED ORTHODONTIC ALIGNER MANUFACTURING AND ASSESSMENT

Resumen de: US2025229463A1

A manufacturing system comprises a holder, a robot arm, a press and a laser. The holder is configured to receive a feature of a dental appliance and to hold the dental appliance by clamping the feature of the dental appliance, wherein the holder holds the feature of the dental appliance at a reference position. The robot arm is configured to retrieve an object and to place the object against the feature at the reference position. The press is configured to apply pressure to press the object against the feature of the dental appliance while the dental appliance is held by the holder. The laser is configured to expose an interface of the dental appliance and the object to coherent light to weld the object to the feature of the dental appliance while the press presses the object against the feature of the dental appliance.

BIOMANUFACTURING SYSTEM, METHOD, AND 3D BIOPRINTING HARDWARE IN A REDUCED GRAVITY ENVIRONMENT

Resumen de: US2025230391A1

A method, apparatus, and system are provided for the printing and maturation of living tissue in an Earth-referenced reduced gravity environment such as that found on a spacecraft or on other celestial bodies. The printing may be three-dimensional structures. The printed structures may be manufactured from low viscosity biomaterials.

ORTHODONTIC TEETH-STRAIGHTENER MADE OF SHAPE-MEMORY POLYMERS, AND METHOD FOR THE PRODUCTION OF SAME

Resumen de: US2025228647A1

An orthodontic teeth-straightener, comprising a splint element which contains, or is entirely made from, a thermoplastic polyurethane having shape-memory properties. The thermoplastic polyurethane having shape-memory properties is selected from the group of polyether polyurethanes and contains hard segments which contain polyurethane units that have been obtained by polyaddition of the isocyanate groups of a diisocyanate to the hydroxyl groups of a diol acting as a chain extender, thereby forming urethane groups. The polyether polyurethane also contains soft segments, which contain, or are entirely made from, polyether units in the form of polyalkylene glycols, wherein the polyether units are bonded to isocyanate end groups of the diisocyanate of the hard segments, thereby forming urethane groups with the hard segments. The thermoplastic polyether polyurethane is both thermo-responsive and water-responsive and thus gives the splint element dual-stimuli responsive shape-memory properties.

Dental Bar Implant and Overdenture and Process for Using.

Resumen de: US2025228652A1

A two-part denture and inlay for implanting within the jaw of an edentulous patient thereby restoring the aesthetics and ability of the patient to eat. The denture has a blade-like lower edge that fits into a corresponding groove in the upper surface of the inlay, in a friction-fit manner, so that the patient cannot easily remove the denture. However, using screws in threaded holes provided in the denture, the dental practitioner can disengage the denture from the inlay and replace the denture, when necessary. Also, a method of using the two-part denture and inlay is provided.

Surgical Implant And Methods Of Additive Manufacturing

Resumen de: US2025228594A1

A method of manufacturing a surgical implant includes simultaneously forming a first component and a second component of the surgical implant. Formation of the first and second components includes depositing a first quantity of material to a building platform and fusing the first quantity of material to form a first layer of the first and second components. The method of manufacturing also includes depositing a second quantity of material over the first layer of the first and second components and fusing the second quantity of material to form a second layer of the first and second components. The surgical implant is fully assembled upon the completion of the formation of the first and second components.

光開始剤、それを含むバイオインク及びハイドロゲルの製造方法

Resumen de: US2025222169A1

The present disclosure relates to a photoinitiator, a bioink including the same, and a method of manufacturing a hydrogel. According to the present disclosure, the photoinitiator of the present disclosure may have water solubility, high molar extinction coefficient, and low cytotoxicity. In addition, the method of manufacturing a hydrogel of the present disclosure may have high cell viability by increasing 3D printing efficiency due to a fast photo-curing rate.

光硬化性組成物及び歯科用製品

Resumen de: JP2023143923A

To provide a photocurable composition which can yield a cured product with the suppressed formation of cracks and breaks and excellent handleability.SOLUTION: A photocurable composition includes a (meth)acrylic monomer component and a photopolymerization initiator, wherein the adhesive force of its cured product is less than or equal to 1.5 N, and the rupture elongation of the cured product is greater than or equal to 20%.SELECTED DRAWING: Figure 1

REMOVABLE DENTAL APPLIANCE INCLUDING SPRING MEMBER AND COMPUTER METHOD OF DESIGNING SAID APPLIANCE

Resumen de: EP4585184A2

The present invention relates to a system comprising an ordered set of removable dental appliances configured to reposition one or more teeth of a patient. Each removable dental appliance in the set of removable dental appliances comprises an appliance body configured to at least partially surround a plurality of teeth of a dental arch of a patient. The appliance body comprises a unitary material defining a shell shaped to receive at least one tooth of the patient and a spring member integrally formed with the shell, wherein the spring member is configured to receive an attachment. The attachment is configured to affix to the at least one tooth. The spring member is configured to apply a spring force to the attachment to cause at least one of a rotation, a translation, a tipping, a torqueing, an extrusion, or an intrusion of the at least one tooth toward a desired position of the tooth when the removable dental appliance is worn by the patient.

フィルム製剤の製造方法及びフィルム製剤の製造システム

Resumen de: WO2023234310A1

This production method for a film preparation comprises: (1) a step for discharging a solution containing at least one pharmaceutical active ingredient from a print head to print the solution onto a soluble substrate film, the pharmaceutical active ingredient being printed onto the soluble substrate film so that the film includes a dose by which a desired effect is exhibited upon administration to a subject. The printed soluble substrate film can be formulated as a drug delivery system selected from a group including an injectable agent, a suppository, and a transdermal patch. The present invention also provides a production system for a film preparation, the system being for implementing the method.

REMOVABLE DENTAL APPLIANCE INCLUDING SPRING MEMBER AND COMPUTER METHOD OF DESIGNING SAID APPLIANCE

Resumen de: EP4585185A2

The present invention relates to a method comprising forming a model of dental anatomy of a patient; and forming, based on the model, a removable dental appliance. The dental appliance comprises an appliance body configured to at least partially surround a plurality of teeth of a dental arch of a patient. The appliance body comprisies a unitary material defining a shell shaped to receive at least one tooth of the patient and a spring member integrally formed with the shell. The spring member is configured to receive an attachment, wherein the attachment is configured to affix to the at least one tooth, and wherein the spring member is configured to apply a spring force to the attachment to cause at least one of a rotation, a translation, a tipping, a torqueing, an extrusion, or an intrusion of the at least one tooth toward a desired position of the tooth when the removable dental appliance is worn by the patient.

TRANSFER APPARATUS FOR ORTHODONTIC APPLIANCES AND RELATED METHODS OF MANUFACTURING

Resumen de: CN119855708A

A method of manufacturing a transfer device includes providing a physical physical model having a shape corresponding to a positive shape of a patient's dental arch and one or more stent assemblies each including a lifting mechanism body releasably connectable to an orthodontic appliance. A transfer device may be formed over the physical entity model, wherein a transfer denture represents a negative replica of at least a portion of the entity model. The transfer device may be used to place the appliance on a patient's dental arch, after which the appliance may be detached from the lifting mechanism body and bonded to the associated tooth.

锆铌合金种植件和锆铌合金种植件制作方法

Resumen de: CN120304980A

本发明涉及种植牙技术领域，具体而言，涉及一种锆铌合金种植件和锆铌合金种植件制作方法。该锆铌合金种植件包括种植体以及基台；种植体的外周配置有连接螺纹；种植体外表层为多孔骨小梁结构，多孔骨小梁结构采用三周期极小曲面结构，且其孔隙相互联通；种植体的外表面覆有锆铌合金金属陶瓷；种植体内部配置连接腔，连接腔内配置连接部；基台配置有用于与连接部可拆卸地连接的锥形连接台，基台在定量压力下压入种植体，在定量拉力下拔出基台。该锆铌合金种植件的种植体表面的多孔结构设计可促进骨组织长入，实现假体与人体骨骼界面的牢固整合，提高假体的稳定性和使用寿命，而且种植体与基台连接稳固，并能够降低金属过敏反应和金属伪影。

一种基于3D打印的用于关节软骨快速配准的弹簧测针系统

Resumen de: CN120304949A

本发明公开了一种基于3D打印的用于关节软骨快速配准的弹簧测针系统，涉及医疗成像与骨科手术导航技术领域。为了解决传统CT成像中软骨无法显影导致的关节配准精度不足的问题；本发明通过3D打印导板个性化定制，定位孔方便安装，弹簧测针组件可调节且数据监测实时，智能配准模块自动处理数据，减少人工操作，提高了手术效率，弹簧测针组件结构合理、弹力可调节，保障了系统在手术中的稳定运行，多体位CT扫描结合先进图像处理和配准技术，构建精确初始模型，弹簧测针组件采集数据结合弹性形变补偿模型实时修正配准误差，提升了配准准确性，为骨科手术导航提供了可靠支持，有助于提高手术成功率，减少患者创伤和手术风险。

牙颌模型

Resumen de: CN223095648U

本实用新型公开一种牙颌模型，为由薄壁围合而成的底面开口的空心模型，包括牙颌部、与牙颌部一体成型的用于支撑牙颌部的底座部，以及设置在底座部内用于提升牙颌模型抗压强度的加强结构，薄壁包括唇颊侧壁和舌侧壁，加强结构横跨牙颌模型的空心部分设置，且加强结构的一端支撑在唇颊侧壁内表面的第一预设位置处，加强结构的另一端支撑在舌侧壁内表面的第二预设位置处；第一预设位置和第二预设位置对应于同一牙齿设置，第一预设位置和第二预设位置分别设置在至少对应于患者左右两侧尖牙至第二双尖牙的下方且与对应牙齿的牙龈线呈预设距离设置；其中，薄壁的厚度为0.5mm‑3mm，加强结构呈柱状，加强结构横截面的特征直径为0.5mm‑3mm。

一种悬空设计的3D打印脑部穿刺导板

Resumen de: CN223095603U

本实用新型涉及医用辅助器械，一种悬空设计的3D打印脑部穿刺导板，包括导板本体；导板本体包括与患者的骨性生理特征相适配的眉弓固定曲面和鼻根固定曲面，鼻根固定曲面由眉弓固定曲面的中段下侧朝下延伸形成，导板本体整体呈T型；导板本体还包括鼻头固定曲面和鼻侧悬伸曲面；鼻头固定曲面由鼻根固定曲面的下部朝下延伸形成，且能够包覆在患者鼻头上；鼻头固定曲面的一侧朝左/右延伸形成有鼻侧悬伸曲面；本实用新型通过眉弓固定曲面、鼻根固定曲面、鼻头固定曲面等进行多点固定，多点固定的形式使得整体的固定更加的稳定，相较传统的简单通过皮肤贴附固定的方式而言，不易产生位移，能够保证穿刺导向的精准性，防止体表组织移动造成的干扰。

用于生成牙齿模型的方法、牙齿模型打印方法及设备

Resumen de: CN120307644A

本申请实施例适用于齿科技术及3D打印技术领域，提供了一种用于生成牙齿模型的方法、牙齿模型打印方法及设备，所述用于生成牙齿模型的方法包括：获取口腔扫描模型，所述口腔扫描模型包括扫描杆模型；确定与所述扫描杆模型匹配的接合装置模型；从所述口腔扫描模型移除所述扫描杆模型，并基于与所述扫描杆模型的位置匹配，添加所述接合装置模型，以生成牙齿模型。应用本方法，可以通过数字化方式获得患者口腔数据，进而根据匹配的接合装置模型生成牙齿模型，实现精确取模。在此基础上，本申请实施例可以采用3D打印技术打印获得相应的实体牙齿，降低人工装配带来的误差，保证打印得到的实体牙齿的精度。

一种药物缓释型医用敷贴

Resumen de: CN120305040A

本发明公开了一种药物缓释型医用敷贴，包括聚氨酯薄膜，聚氨酯薄膜其中一面经过激光刻蚀处理，在聚氨酯薄膜上刻蚀出载药槽；药物负载于缓释骨架上，构成药物‑骨架负载结构，药物‑骨架负载结构负载于载药槽内。本发明医用敷贴中的药物负载于缓释骨架上，缓释骨架通过三维微纳打印制备得到，缓释骨架的形状根据载药槽的形状进行定制，使载药槽内缓释骨架的数量最大化，药物负载于缓释骨架上，从而载药槽内可以容纳更多的药物，提升医用敷贴的载药量，且药物‑骨架负载结构，可以起到良好的缓释效果，使用7天后仍具有释药能力，从而大大提高了医用敷贴的利用率和耐久性，避免了换药过程中的二次创伤，有利于创面修复。

用于混合药物复合物的方法和适配器

Resumen de: WO2024076590A2

Embodiments of an adapter, a system including the adapter, and methods of using the adapter may be for mixing a first substance and a second substance. The adapter may include a body having a first port configured to connect with a first container to receive a first substance, a second port configured to connect with a second container to receive a second substance, a third port configured to connect with a recipient container to output a mixture of the first substance and the second substance, and a mixing chamber having a first portion in communication with the first port and the second port and a second portion in communication with the third port. The adapter may further include a mixing pin inserted into the mixing chamber. In some embodiments, the mixing pin at least partially defines at least one microfluidic path for mixing the first substance and the second substance. In some embodiments, at least one of the first channel and the second channel are oriented offset of a central plane of the body.

制造种植牙模的方法和3D打印系统

Resumen de: CN120304981A

本申请实施例适用于齿科技术及3D打印技术领域，提供了一种制造种植牙模的方法和3D打印系统，该方法包括：获取具有替代体接口的种植牙模模型；基于所述种植牙模模型，通过3D打印制造由树脂构成的种植牙模。其中，上述替代体接口可以包括螺纹状的连接结构。采用上述方法，可以解决包含替代体的牙模在与基台装配时存在的问题，降低装配难度，提高牙模与基台的装配精度。

用于分配粉末的设备和方法

Resumen de: US2022016831A1

Apparatus and associated methods are provided for digitally controlled powder deposition. The apparatus comprises a supply chamber configured to maintain a reservoir of powder in a fluidised state, and one or more dispenser elements. The supply chamber is further configured to direct a flow of the fluidised powder from the reservoir to an orifice, causing it to be dispensed from the orifice.

基于三重动态氢键的纳米甲壳素温敏自愈合水凝胶粘合剂及其制备方法与3D打印应用

Resumen de: CN120310468A

本发明公开了基于三重动态氢键的纳米甲壳素温敏自愈合水凝胶粘合剂及其制备方法与3D打印应用，涉及功能高分子复合材料技术领域，基于三重动态氢键的纳米甲壳素温敏自愈合水凝胶粘合剂，包括：草酸水解甲壳素纳米纤维，直径15‑40nm，长径比＞150，羧基含量0.6‑0.75mmol/g；聚乙烯醇，浓度10‑60wt％，醇解度88‑99％，聚合度1700±200；单宁酸，浓度1‑20wt％；其中，草酸水解甲壳素纳米纤维与聚乙烯醇的质量比为1:10，TA占水凝胶总质量的5‑20wt％。这项工作主要是以草酸水解的纳米甲壳素、单宁酸和PVA为主要介质，以强烈的氢键相互作用形成了具有一定内聚强度、粘附性好、可自愈合、可注射并且兼具温敏性的OTP胶粘剂。该胶粘剂制备方法简单高效，其良好的辅助伤口愈合性能可实现高效可控的3D打印。

一种仿天然角膜纤维排列的超低溶胀人工角膜及制备方法

Resumen de: CN120305460A

本发明提供一种仿天然角膜纤维排列的超低溶胀人工角膜及制备方法，属于生物医用材料技术领域，本发明将I型胶原蛋白溶解于PBS缓冲液中，加入光功能化修饰的活性试剂进行化学修饰，避光搅拌后冷冻干燥，得到光功能化胶原蛋白；将光功能化胶原蛋白溶解，然后通过静电纺丝制备胶原纤维膜；将生物墨水和胶原纤维膜进行相变DLP 3D生物打印，获得胶原纤维夹层结构的人工角膜。本发明通过DLP 3D生物打印实现多层排列，模拟天然角膜的纤维走向，显著提升力学各向异性；GelMA/HA‑DN与光交联胶原纤维的复合相变DLP 3D打印方式，使其具有良好的可制造性，维持高透光率，同时保持高力学强度。

一种纳米纤维纱线3D打印复合支架及其制备方法与应用

Resumen de: CN120305453A

本发明公开了一种纳米纤维纱线3D打印复合支架的制备方法，所述制备方法包括以下步骤：S1：将纺丝所需聚合物和/或无机源溶于对应溶剂，得到纺丝前驱体溶液；S2：使用步骤S1所述的纺丝前驱体溶液采用纳米纤维纺纱设备进行纺纱，得到纳米纤维纱线；S3：利用3D打印技术打印得到聚合物框架；S4：将S2中所述的纳米纤维纱线在S3所述聚合物框架中进行编织，得到纳米纤维纱线3D打印复合支架。该制备方法制备得到的支架不仅具有3D打印的几何结构，还具有纳米纤维的高比表面积和生物活性，能够更好地模拟天然组织的微环境，可以克服传统支架的局限性，提供了更理想的组织工程支架。

錠剤用インクジェットインクおよび錠剤印刷物

Resumen de: JP7708266B1

【課題】本発明は、優れた印刷安定性を維持しつつ、インクの定着性（耐転写性）を向上させたインクジェットインクおよび当該インクジェットインクで印刷した印刷部を備える錠剤印刷物を提供することを目的とする。【解決手段】本実施形態に係るインクジェットインクは、可食性の染料と、粘着剤と、溶媒として水およびエタノールとを含み、前記粘着剤として液体状の粘着剤のみを含む。【選択図】なし

光硬化性組成物および放射線を対象に送達する方法

Resumen de: AU2023293120A1

The disclosure is directed in part to polymerizable biocompatible or bioabsorbable compositions comprising styrene, N-vinylpyrrolidone or acrylate monomers, further comprising epoxide, urethane, polyether, or polyester oligomers and free radical initiators that can incorporate a radioactive source, including diagnostic or therapeutic radioisotopes and radioisotope precursors, to treat subjects with certain conditions, and methods of producing and use thereof.

通过基于光的结构化固化制备的用作乳房植入物的3D脂肪组织支架

Resumen de: WO2024120579A1

The invention relates to a 3D fat tissue structure for use as a breast implant for surgical, therapeutic, prophylactic or aesthetic reconstruction, construction or replacement of human breast tissue, wherein the 3D fat tissue structure has a matrix that is made of a biocompatible polymer and colonised with a plurality of biological cell types, wherein the colonisation with the plurality of cell types takes place during the construction of the matrix made of a biocompatible polymer, in the course of which a blood vessel structure network is formed within the 3D fat tissue structure, characterised in that, for the construction of the matrix made of a biocompatible polymer, light-based, structuring curing of a photopolymerisable or photocrosslinkable fluid is used. The invention also relates to the use of a 3D fat tissue structure as a breast implant in humans, wherein the 3D fat tissue structure has a matrix made of a biocompatible polymer, which is colonised with a plurality of cell types, wherein the colonisation with the plurality of cell types takes place during the construction of the matrix made of a biocompatible polymer, in the course of which a blood vessel structure network is formed within the 3D fat tissue structure, characterised in that, for the construction of the matrix made of a biocompatible polymer, light-based, structuring curing of a photopolymerisable or photocrosslinkable fluid is used.

盐酸右美托咪定微针及其制备方法和其应用

Resumen de: CN120284842A

本发明涉及一种盐酸右美托咪定微针，所述微针由载药针体层和基底层制成，其中，载药针体层：基底层的体积比为1:100‑200，载药针体层中由聚乙烯吡咯烷酮：盐酸右美托咪定按照质量比为1‑15:1制得，基底层由聚乙二醇二丙烯酸酯光交联制得。本发明的盐酸右美托咪定微针具有起效快速，药效维持时间长，对皮肤无刺激性并避免了感染风险，实现了盐酸右美托咪定的经皮精准给药，显著提高其生物利用度及用药的安全有效性。

一种基于4D打印的膝关节矫形支具制备及驱动方法、支具结构

Resumen de: CN120297073A

本发明涉及一种基于4D打印的膝关节矫形支具制备及驱动方法、支具结构，其中制备方法及驱动方法通过结合膝关节三维扫描体表数据和医学影像，建立具有膝关节畸形特征的生物力学模型，为打印支具提供模型基础，为驱动支具提供预测参数，提高支具实用性；其中支具结构包括第一矫形板和第二矫形板，并通过第一连板和第二连板连接，便于组装且穿戴后不影响行走；驱动方法包括利用具有膝关节畸形特征的生物力学模型，进而结合深度学习算法构建膝关节矫形目标角度预测模型，为矫形支具的各次形态改变提供参照，且模型可以根据具体阶段调整继续使用，提高效率，提高资源利用率。

一种用于光固化3D打印的氧化锆膏料及其制备方法

Resumen de: CN120289180A

本发明公开了一种用于光固化3D打印的氧化锆膏料及其制备方法，其原料按重量份包括：氧化锆掺杂物：72％‑76％；光敏树脂预混液：12％‑14％；流变助剂：1％‑2％；分散剂：0.8％‑1.5％；消泡剂：0.05％‑0.1％；流平剂：0.05％‑0.1％；溶剂：10％‑12％；着色剂：0.3％‑0.6％；本发明涉及增材制造技术领域。该用于光固化3D打印的氧化锆膏料及其制备方法，通过三级级配的氧化锆掺杂物作为主体材料，在光敏树脂预混液、流变助剂、分散剂、消泡剂、流平剂和溶剂的配合下，确保各成分充分分散，为氧化锆膏料在3D打印成型过程中提供均匀稳定的保障，有效消除成品的表面和内部缺陷，并且利用着色剂模拟天然牙色，既具备良好的加工性能又拥有良好的力学性能、生物相容性以及美学效果。

光固化树脂、制备方法及应用

Resumen de: CN120289716A

本申请公开了一种光固化树脂、制备方法及应用，属于光固化3D打印技术领域。本申请提供的光固化树脂包括聚氨酯丙烯酸酯低聚物、改性丙烯酸酯低聚物和活性稀释剂，其中，聚氨酯丙烯酸酯低聚物可以提高光固化树脂的韧性和反应速度，降低光固化树脂的体积收缩，改性丙烯酸酯低聚物可以提高光固化树脂的耐久性，调节硬度和韧性，同时降低光固化树脂的体积收缩，活性稀释剂可以提高光固化树脂的硬度和韧性；采用聚氨酯丙烯酸酯低聚物、改性丙烯酸酯低聚物和活性稀释剂复配，并限定各组分用量，使各组分充分发挥协同作用，从而使光固化树脂在具有较低体积收缩、较高硬度的同时保持高韧性与耐久性。

载枯草芽孢杆菌的3D打印多孔聚己内酯胶囊及其制备方法

Resumen de: CN120284897A

本发明提供了载枯草芽孢杆菌的3D打印多孔聚己内酯胶囊及其制备方法。所述胶囊包括壳层结构和由壳层结构包围而成的含有包裹物的腔体，所述壳层结构由外到内依次包括外壳层和透析膜层，所述包裹物为枯草芽孢杆菌；其中，所述外壳层的原料包括聚己内酯、聚乙烯、改性聚丙烯、热稳定剂；所述透析膜层的原料包括聚己内酯、聚乙烯醇抗氧化剂、增塑剂、热稳定剂；载枯草芽孢杆菌的3D打印多孔聚己内酯胶囊能摄取肠道内的锰离子，同时限制载枯草芽孢杆菌进入肠道，随后胶囊携带枯草芽孢杆菌和离子排出体外，能够有效降低人体内锰离子含量，有助于阻止白色脂肪向米色脂肪转变，抑制恶病质形成。

一种3D打印外覆甲敷料的制备方法

Resumen de: CN120285263A

本发明公开了一种3D打印外覆甲敷料的制备方法，制备用于甲床创伤的外覆甲敷料，具体步骤如下：步骤1：将热塑性生物相材料与抑菌材料混合，经干燥和熔融挤出制备得到复合线材；其中，所述热塑性生物材料为聚乳酸PLA、热塑性聚氨酯TPU、聚己内酯PCL或聚羟基脂肪酸酯PHA中的任意两种，且任意两种热塑性生物材料的质量比为(3～7)：(3～7)；抑菌材料为无机盐晶须，按质量百分比计算，抑菌材料的质量占热塑性生物材料总质量的百分比为0.5wt％～2wt％；步骤2：采用熔融沉积技术进行3D打印成型，得到所述外覆甲敷料。

一种多功能交联双网络仿生水凝胶支架及其制备方法和应用

Resumen de: CN120285289A

本发明属于生物材料及生物医学工程技术领域，特别涉及一种多功能交联双网络仿生水凝胶支架及其制备方法和应用。多功能交联双网络仿生水凝胶支架包括碳负载二氧化铈和钆离子交联双网络水凝胶，通过3D打印技术制备出具备梯度力学强度的钆离子交联双网络水凝胶支架。本发明的多功能交联双网络仿生水凝胶支架具有抗肿瘤、抗炎和仿生力学性能等特点，在体外和体内均展现了良好的抗炎、促成骨和促成软骨再生能力。在808 nm近红外(NIR)照射下表现出优异的光热性能，照射后，高温(高于45°C)可以用于抗肿瘤治疗，有效抑制肿瘤复发，而温和的温度则能促进软骨和骨的再生。本发明采用3D打印技术可实现对不规则缺损区域形状特异性、个性化的水凝胶支架打印。

一种基于3D打印的个性化口咽通气道装置

Resumen de: CN120284580A

本发明涉及医疗器械技术领域，特别涉及一种基于3D打印的个性化口咽通气道装置。本发明的基于3D打印的个性化口咽通气道装置包括3D打印的咽通气道主体，所述咽通气道主体一端设有限位部，所述咽通气道主体的内壁上设有气流感应器，所述限位部上设有处理器、电源和通讯器，所述处理器分别连接所述电源、气流感应器和通讯器，所述电源连接所述通讯器。优点：结构设计简单、合理，装置根据患者的口咽形状个性化定制，佩戴更加舒适，同时，能够在OSA患者睡眠时，辅助打开气道，避免口腔内软组织堵塞气道，同时，能够实时监测气道的通畅情况，记录相关数据，帮助患者及医护人员了解睡眠呼吸状况，以便及时进行调整及救治。

一种复合血管支架及其制备方法

Resumen de: CN120284553A

本发明提供了一种复合血管支架及其制备方法，涉及血管支架技术领域。本发明通过结合3D打印中的熔融沉积制造技术和层压制造技术制备聚合物/金属复合血管支架，利用FDM技术制备两层聚合物薄片，并在两层薄片间加入一层金属丝，随后通过加热加压工艺，使聚合物薄片之间紧密粘合并完全包覆金属丝，得到聚合物/金属正弦形片状结构，然后将聚合物/金属片弯折成管状结构，并将两端金属丝并拢后打结固定，得到复合血管支架。本发明的复合血管支架具有良好的径向支撑力，克服了现有含聚合物材料的复合血管支架的不足，能够满足临床使用对支架径向强度的要求。

GRAFT SCAFFOLD FOR CARTILAGE REPAIR AND PROCESS FOR MAKING SAME

Resumen de: US2025222166A1

The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.

A DEVICE FOR SKIN BIOPRINTING AND A METHOD OF MAKING A DEVICE FOR SKIN BIOPRINTING

Resumen de: US2025221814A1

There is provided a device for skin bioprinting and a method of making a device for skin bioprinting, the device comprising: a dispenser module configured to actuate and dispense a bioink from a first chamber, and to actuate and dispense a crosslinker from a second chamber: a storage module coupled to the dispenser module, the storage module comprising the first chamber for storing the bioink and the second chamber for storing the crosslinker; a mixing module coupled to the storage module for mixing the bioink and the crosslinker dispensed from the first and second chambers respectively; and a rotatable applicator coupled to the mixing module for rotatably applying a mixture of the bioink and crosslinker from the mixing module onto a surface of a patient in need of skin regeneration.

３Ｄプリンターを使用した透明矯正装置の製造方法

Resumen de: CN119403514A

The invention discloses a method for manufacturing a transparent correction device based on a 3D printer, namely a method for executing the transparent correction device through a computer, and the method comprises the following steps: (A) scanning an oral cavity structure of a patient, and generating and storing data related to the shape of the oral cavity structure; (B) displaying the oral cavity structure of the patient on the basis of the data stored in the step (A); (C) setting detailed correction information on the oral cavity structure of the patient displayed in the step (B), the step (C) comprising: selecting a tooth to be corrected in a state where the oral cavity structure of the patient is displayed, and inputting correction values of the rotation amount and the movement amount of the selected tooth; a step for inputting the scale of the transparent correction device on the basis of the input correction value; and a step of inputting the thicknesses of the portion where the transparent orthodontic device is in contact with the orthodontic teeth and the portion where the transparent orthodontic device is not in contact with the orthodontic teeth, respectively, so that the thicknesses of the transparent orthodontic device are partially differentiated.

マイクロポストアレイ装置及び生体適合性足場構築物

Resumen de: CA3203310A1

A biocompatible scaffold construct may include a biocompatible hydrogel and at least one biomaterial microfiber strand wound to form a plurality of microfiber segments in proximity to one another and arranged in an organized configuration.

BIOMATERIAL FOR USE IN THE DENTAL FIELD

Resumen de: AU2023410422A1

The present invention relates to a crosslinkable polymer composition comprising at least one calcium phosphate, at least one biocompatible and biodegradable organic polymer or one of its precursors, and Zn-ZnO core-shell particles, to a biomaterial obtainable by photopolymerization of such a crosslinkable polymer composition, to a process for preparing such a composition and such a biomaterial, and to the use of such a biomaterial for various applications in the field of health.

3D PRINTING COMPOSITIONS FOR STAIN RESISTANT AND MORE TRANSPARENT DENTAL MATERIALS FROM POLYOLEFIN DERIVED POLYOLS

Resumen de: WO2025147626A1

The present disclosure provides novel oligomer compounds (e.g., non-polar oligomers) that can produce desirable polymeric materials (e.g., with polar reactive diluents), polymer compositions, and/or photo-curable resins that have excellent stain resistance. Further provided herein are methods of producing polymerizable compositions, resins, devices, and polymeric materials. Also provided herein are methods of using polymerizable compositions, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances with increased stain resistance.

METHOD OF MANUFACTURE OF CUSTOM CRANIAL REMODELING DEVICES BY ADDITIVE MANUFACTURING

Resumen de: US2025225753A1

A method for fabricating a custom cranial remodeling device for correction of cranial deformities in a subject is described. The method comprises generating a three-dimensional head data file for the subject and determining contour lines on the head. The method further comprises automatically generating a modified head shape data file. Still further the method includes utilizing the modified head shape data file to generate a shape for a desired custom cranial remodeling device and restricting growth of the head in first areas.

METHOD OF MANUFACTURE OF CUSTOM CRANIAL REMODELING DEVICES BY ADDITIVE MANUFACTURING

Resumen de: US2025225754A1

A method for fabricating a custom cranial remodeling device for correction of cranial deformities in a subject is described. The method comprises generating a three-dimensional head data file for the subject and determining contour lines on the head. The method further comprises automatically generating a modified head shape data file. Still further the method includes utilizing the modified head shape data file to generate a shape for a desired custom cranial remodeling device and restricting growth of the head in first areas.

THREE-DIMENSIONAL ANATOMICAL PARTS

Resumen de: US2025225755A1

Anatomical parts including surgical trainers and prosthesis and methods of creating three-dimensional anatomical parts by gathering three-dimensional image data from multiple sources, indexing characteristics from the data and then averaging the data to create new anatomical parts that have averaged characteristics. The disclosed methods also enable bonding of various materials through printed lattices.

INTRAOPERATIVE ANATOMICAL LANDMARK IN THYROID SURGERY - RECURRENT LARYNGEAL NERVE INTERSTITIAL FLUID SHEATH

Resumen de: US2025225892A1

The present disclosure is directed to an artificial 3D scaffold of thyroid comprising artificial laryngeal and tracheal framework, wherein the scaffold comprises an artificial interstitial fluid sheath. Further, methods for obtaining a 3D scaffold according to the present disclosure and methods for identification of the recurrent laryngeal nerve in a subject, are disclosed.

ANTIBACTERIAL BIOMEDICAL IMPLANTS AND ASSOCIATED MATERIALS, APPARATUS, AND METHODS

Resumen de: US2025222178A1

Methods for improving the antibacterial and/or bone-forming characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant may comprise a composite of a silicon nitride ceramic powder dispersed within a poly-ether-ether-ketone (PEEK) or a poly-ether-ketone-ketone (PEKK) substrate material. In some implementations, the biomedical implant may be 3D printed.

PHOTOINTIATOR, BIOINK INCLUDING THE SAME, AND METHODE OF MANUFACTURING HYDROGEL

Resumen de: US2025222169A1

The present disclosure relates to a photoinitiator, a bioink including the same, and a method of manufacturing a hydrogel. According to the present disclosure, the photoinitiator of the present disclosure may have water solubility, high molar extinction coefficient, and low cytotoxicity. In addition, the method of manufacturing a hydrogel of the present disclosure may have high cell viability by increasing 3D printing efficiency due to a fast photo-curing rate.

METHOD OF FORMING AN ALIGNED TISSUE OR TISSUE CONSTRUCT, A TISSUE OR TISSUE CONSTRUCT, AND BIOINK

Resumen de: US2025222168A1

Described herein is a method of forming an aligned tissue or tissue construct. The method includes extruding a bioink material through a nozzle onto a support to form a structure of the bioink material, the bioink material comprising anisotropic organ building blocks (aOBBs) comprising extracellular matrix material (ECM) and cellularly aligned cells, wherein the aOBBs align parallel to the direction of the extrude path, and polymerizing the structure of the bioink material, thereby forming the tissue or tissue construct having arbitrarily programmed alignment. Also, described is a tissue or tissue construct produced by the method, as well as bioink material used to produce the same.

METHOD FOR MANUFACTURING TRANSPARENT BLEACHING TRAY

Resumen de: US2025222654A1

The method of manufacturing a transparent whitening tray according to the present invention includes 3D printing of the whitening tray using the composition for forming a transparent whitening tray as a raw material (S10), removing uncured resin and liquid from the whitening tray obtained in the above step (S20), post-curing the whitening tray obtained in the above step (S30), post-heat treating the whitening tray obtained in the above step (S40), and washing the whitening tray obtained in the above step (S40).

METHOD OF ORGANOID DERIVED PRODUCTION OF HUMAN EXTRACELLULAR MATRIX HYDROGELS

Resumen de: US2025223568A1

Disclosed herein is a method of extracting extracellular matrix (ECM) from organoids via decellularization and hydrogels formed from methods thereof. The hydrogels can be used in medical devices for regenerative medicine like tissue grafts, and research and development applications to enhance disease modeling utilizing 3D bioprinting or other hydrogel embedding processes. The hydrogels can also be used to enhance tissue culture flasks for cells by offering a softer environment than polystyrene for cell culture. The hydrogels can be used in drug and vaccine delivery as well.

TALUS FORMATION AND IMPLANTATION METHOD

Resumen de: US2025221826A1

A process for printing a talus implant comprising the steps of scanning a joint for a damaged talus, and scanning a contralateral joint for a healthy talus. Next, the process includes obtaining dimensions for a talus based upon an initial scan and then obtaining dimensions for a talus based upon the scan of the contralateral joint. Next the process includes inverting the dimensions of the talus in the contralateral joint and then comparing the dimensions of the calculated talus with a pre-set of dimensions in a database. Next the process includes exporting a set of dimensions to a printer to print a talus implant.

METHOD AND SYSTEM FOR FABRICATING OBJECT FEATURING PROPERTIES OF A HARD TISSUE

Resumen de: US2025221824A1

A method of additive manufacturing an object featuring properties of a hard bodily tissue, comprises: dispensing and solidifying a plurality of non-biological material formulations to sequentially form a plurality of hardened layers in a configured pattern corresponding to a shape of the object. The method forms voxel elements containing different material formulations at interlaced locations to provide a three-dimensional textured region spanning over the portion. The material formulations and the interlaced locations are selected such that the textured region exhibits, once hardened, a stress variation of at most ±20% over a strain range of from about 0.1% to about 0.3%.

MECHANICAL ENTRAPMENT STRUCTURES AND METHODS OF COATING ADDITIVELY MANUFACTURED OBJECTS USING THE SAME

Resumen de: US2025221803A1

Provided herein are methods of making a coated object that include applying a coating composition to a surface of an object that comprises a plurality of entrapment structures thereon, wherein the coating composition is on at least a portion of the plurality of entrapment structures; and curing and/or solidifying the coating composition to form the coated object. Also provided are coated objects formed by such methods. Additionally, provided herein are methods of bonding a first surface to a second surface wherein the first surface and/or the second surface comprises a plurality of entrapment structures thereon. Composite articles are also provided herein.

ARTICLES INCLUDING A MICROSTRUCTURED CURVED SURFACE, TOOLING ARTICLES, AND METHODS

Resumen de: WO2024047419A1

The present disclosure provides a microstructured article including a thermoplastic polymer shaped to have a curve. At least a portion of the curve includes a microstructured surface of utilitarian discontinuities and the microstructured surface includes peak structures and adjacent valleys. The peak structures and the curve are formed of a single piece of the thermoplastic polymer. A method of making the microstructured articles is also provided including a) obtaining a tool shaped to include at least one of a protrusion or a concavity; b) disposing a microstructured film on at least a portion of the tool including the protrusion and/or the concavity; and c) thermoforming a single piece of thermoplastic polymer onto the tool to form a microstructured article shaped to include a curve. The curve is an inverse of the protrusion or the concavity of the tool.

SYNTHETIC BONE GRAFTS AND METHODS FOR THEIR PREPARATION

Resumen de: WO2024047045A1

The present invention provides methods for the preparation of synthetic bone grafts which are made of a composition comprising two matrixes, one ceramic including interlocked CDHA crystals, and another of one or more binder(s), the two matrixes being admixture. The method comprises the preparing of an ink composition, the 3D-printing, and the hardening of the binder and ceramic components, in this order. The resulting bone grafts, which are characterized by including the two matrixes in admixture, shows improved mechanical properties as well as excellent biological properties.

変形部材、変形部材の製造方法、マスク、カプセル、カテーテル

Resumen de: JP2025103477A

【課題】より簡単に作製することができる変形部材を提供する。【解決手段】変形部材１０は、液体を膨潤させることにより膨潤する膨潤性ゲルからなる板状の変形部材であって、一方の表面に複数の溝１１が並列に延びている。【選択図】図１

PHOTOINTIATOR, BIOINK INCLUDING THE SAME, AND METHODE OF MANUFACTURING HYDROGEL

Resumen de: EP4582433A1

The present disclosure relates to a photoinitiator, a bioink including the same, and a method of manufacturing a hydrogel. According to the present disclosure, the photoinitiator of the present disclosure may have water solubility, high molar extinction coefficient, and low cytotoxicity. In addition, the method of manufacturing a hydrogel of the present disclosure may have high cell viability by increasing 3D printing efficiency due to a fast photo-curing rate.

TOOL FOR USE AS A MICROMANIPULATOR AND METHOD FOR PRODUCING THE TOOL

Resumen de: WO2024120583A1

The invention relates to a tool for use as a micromanipulator and to a method for producing the tool. The tool consists of a plurality of parts in the form of - a frame (1) which is oriented along a longitudinal axis (L) and which is arranged as a hollow body around an interior, - at least one manipulator element (2) arranged on a first end face (1.1) of the frame (1), and - at least one actuation element (3) which is arranged on a second end face (1.2) opposite the first end face (1.1) and which is mounted slidably and axially movably in the interior of the frame (1), said parts being connected interlockingly and movably to one another by means of necessary connecting and bearing elements, and the tool being entirely generated by additive manufacture, including all the necessary gaps between the parts movably connected to one another. According to the method, the tool with all its parts and with the gaps between the movable parts is manufactured entirely by additive manufacture in one processing operation.

SURGICAL INSERT AND BONE CEMENT

Resumen de: WO2024047317A1

The present invention relates to a surgical insert (1) comprising a first layer (11) and a second layer (12), wherein the first layer and the second layer comprise openings (111, 112) having a figure-of-eight shape. The invention also relates to a bone cement comprising a pulverulent solid phase that comprises natural polysaccharides and a ceramic filler, a liquid acrylate, and a polymerising agent.

GUIDANCE IN SPATIAL SETUPS OF A ROOM IN A MEDICAL FACILITY

Resumen de: WO2024047098A1

The present invention relates to guidance in spatial setups of a room in a medical facility. In order to provide improvements for a facilitated work procedure in medical interventions, a device (10) for guidance in spatial setups of a room in a medical facility is provided that comprises a data input (12), a data processor (14) and an output interface (16). The data input is configured to provide procedure data (18) about a current executed medical procedure. The data input is also configured to provide spatial data (20) of at least one of the group of staff and equipment relating to the currently executed medical procedure. The data processor is configured to calculate upcoming physical movement of at least one of the group of the staff and the equipment based on the procedure data and the spatial data procedure data. The data processor is also configured to determine, based on the calculated upcoming physical movement, at least one of the group of equipment movement instructions (22) and staff spatial guidance (24). Further, the output interface is configured to provide at least one of the group of the equipment movement instructions and the staff spatial guidance.

一种骨再生多重仿生支架材料及其制备方法

Resumen de: CN120267891A

本发明公开了一种骨再生多重仿生支架材料及其制备方法，涉及仿生骨技术领域；本发明的一种骨再生多重仿生支架材料及其制备方法，是先以聚乳酸嵌段共聚物为原料采用3D打印技术制得符合骨缺损形貌的基底支架，再将基底支架在胶原蛋白混合溶液和改性层状双氢氧化合物溶液中进行交替浸渍多次，在基底支架表面形成由胶原蛋白/层状双氢氧化合物组成的仿生基质层，最后将表面附着有仿生基质层的基底支架依次在磷酸氢二钾和氯化钙溶液进行多次交替浸泡，在表面附着有仿生基质层的基底支架上原位矿化形成钙磷酸盐纳米粒子，最后进行清洗、干燥得到；本发明制得的骨再生多重仿生支架材料的生物相容性较好，力学性能较好。

基于多材料数字化光处理的个性化耳模一体制造方法

Resumen de: CN120269828A

本发明实施例公开了一种基于多材料数字化光处理的个性化耳模一体制造方法，涉及增材制造技术领域。其中，方法包括：获取特定患者的个性化耳模三维数值模型；为数值模型添加基于助听器自重的静态载荷，以及基于咀嚼运动周期性力的动态载荷，并基于添加的载荷对数值模型进行动态应力分析；基于应力分析结果，在数值模型中划分不同硬度的材料区域，包括刚性支撑区域、柔性密封区域和过渡区域；根据应力梯度线，确定过渡区域内各位置处用于DLP三维打印的刚性材料和柔性材料的体积分数；根据体积分数，以及刚性支撑区域和柔性密封区域的打印能量密度，确定过渡区域内各位置处的打印能量密度。本实施例能够提高耳模制造的质量和效率。

一种具有光敏抗菌性的钙-钛八面体及其制备方法和应用

Resumen de: CN120269016A

本发明公开了一种具有光敏抗菌性的钙‑钛八面体骨缺损修复复合材料及其制备方法。本发明通过抑制病源微生物活性，重建骨内微观‑宏观结构，纠正微环境离子‑结构紊乱，促进感染性骨缺损再生。钙‑钛八面体复合材料具有独特的光催化效应，在420‑460nm波长的蓝光催化下能有效抑制细菌生长。此外，在微酸性环境下，八面体离子笼内的Ca2+与H+自发进行离子交换，升高微环境pH，释放Ca2+辅助骨修复。钙‑钛八面体与胶原类支架交联构成的复合支架材料具备良好的力学性能，可以基于应力匹配，模拟各种骨质类型，恢复骨宏观结构完整性。

一种骨软骨修复支架及其制备方法

Resumen de: CN120267892A

本申请公开了一种骨软骨修复支架及其制备方法，其中，骨软骨修复支架包括依次连接的软骨下骨层、钙化软骨层以及软骨层，钙化软骨层包括钙化软骨上层、钙化软骨中层、钙化软骨下层，以及镶嵌在钙化软骨上层、钙化软骨中层内的多孔凝胶，本申请实施例中，采用上述的一种骨软骨修复支架及其制备方法，采用分层结构模拟人体生理软骨，通过钙化软骨层的分层及梯度孔隙率设计，不仅提升了支架的柔韧性，改善支架的使用性能，而且能够确保支架在植入到骨软骨缺损部位后能够快速招募患者的自体血液，从而引导骨髓间充质干细胞在软骨层分化为软骨细胞，促进软骨组织生成。

一种金属增材制造高耐磨异构股骨髁假体及其制造方法

Resumen de: CN120267444A

本发明公开了一种金属增材制造高耐磨异构股骨髁假体及其制造方法，假体包括：第一平面、第二平面、第三平面以及第四平面，各平面沿着根据患者的股骨远端的骨性解剖特征排列并一体化成型；每个平面包括细晶层、强韧基体层和力学匹配多孔接触层，所述力学匹配多孔接触层与股骨远端的创面接触，所述强韧基体层与力学匹配多孔接触层呈一体化，所述细晶层设置在最外层，所述力学匹配多孔接触层具有多孔结构；所述第二平面设有用于第二平面上固定假体的固定钉。本发明通过利用激光原位重熔技术对假体运动曲面进行作用，假体表面金属组织快速凝结形成晶粒细化，从而实现膝关节假体表面性能的提高。

光引发剂、包含其的生物墨水以及制造水凝胶的方法

Resumen de: EP4582433A1

The present disclosure relates to a photoinitiator, a bioink including the same, and a method of manufacturing a hydrogel. According to the present disclosure, the photoinitiator of the present disclosure may have water solubility, high molar extinction coefficient, and low cytotoxicity. In addition, the method of manufacturing a hydrogel of the present disclosure may have high cell viability by increasing 3D printing efficiency due to a fast photo-curing rate.

METHOD AND SYSTEM FOR MANUFACTURING PATIENT SPECIFIC SURGICAL METAL PLATES USING SCREW HOLE INFORMATION BASED ON SURGICAL PLANNING

Nº publicación: KR20250103322A 07/07/2025

Solicitante:

경북대학교산학협력단주올소테크