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ALIGNER MANUFACTURING SYSTEMS

Resumen de: US20260192507A1

A system is configured to manufacture multiple aligners simultaneously. The system includes a plate configured to secure first and second molds that are based on first and second digital models associated with a dental arch of a patient corresponding to first and second stages of an orthodontic treatment. The system further includes a heater configured to heat a sheet of plastic to generate a heated sheet and a mask configured to surround the sheet of plastic during heating of the sheet of plastic to minimize heat transfer to other sheets of plastic and to substantially provide a thermal seal between the heater and the sheet of plastic. The system further includes a thermoforming chamber configured to simultaneously thermoform the heated sheet over the first and second molds to form first and second aligners shaped to fit the dental arch at the first and second stages of the orthodontic treatment.

TEXTILE SEAL-FORMING STRUCTURE WITH MULTIPLE CURVATURES

Resumen de: AU2026204772A1

A patient interface including a seal-forming structure with a textile membrane that has at least one hole such that the flow of air at a therapeutic pressure is delivered to at least an entrance to the patient’s nares and/or an entrance to the patient’s mouth. The seal-forming structure is constructed and arranged to maintain the therapeutic pressure in a cavity of a plenum chamber throughout the patient’s respiratory cycle, in use. The textile membrane includes a first portion that is held in a relaxed state and a second portion that is held in a taut state. The taut state of the second portion is configured to allow the seal-forming structure to include a three-dimensional shape that has multiple curvatures. un u n

STRETCHABLE AND HIGHLY CONDUCTIVE CRUMPLED GRAPHENE-BASED FILMS FOR MULTIFUNCTIONAL APPLICATIONS

Resumen de: US20260193139A1

Embodiments relate to a nanocomposite material including a graphene-based 3D porous scaffold coated with active nanoparticles and to methods of making and using the material. The nanocomposite material exhibits high electrical conductivity, mechanical stretchability, and surface roughness, achieved through laser scribing, electrodeposition, and pre-strain transfer printing to induce crumpling. Embodiments further relate to a device including a crumpled nanocomposite material as an electrode and to methods of making and using the device.

AM OPTIMIZED DISPERSION STRENGTH BETA-TITANIUM ALLOY

Resumen de: EP4772201A1

0001 Disclosed herein is a biocompatible composite material and a method of preparing a powder containing same. The biocompatible material can include a matrix and a second-phase dispersion. The matrix can include primary particles forming a titanium alloy. The second-phase dispersion can include secondary particles each encompassed by one of the primary particles of the matrix. The method can include preparing an ingot having the biocompatible material and atomizing the ingot to produce a composite material powder.

DUAL MODE GEOFENCING FOR MEDICAL DEVICES

Resumen de: EP4773117A2

0001 An infusion pump includes a housing, a wireless transceiver, a pump motor mounted within the housing, a location sensor configured to provide information associated with a location of the infusion pump, a battery conductively coupled to the wireless transceiver, the pump motor, the location sensor and processor(s), and memory. The infusion pump is configured to monitor, using the location sensor, a geofence parameter of the infusion pump, determine a change in the location of the infusion pump based on the geofence parameter, identify an operation mode of the infusion pump associated with the geofence parameter, and automatically switch, responsive to the changed location, the operation mode of the infusion pump from a first mode currently programmed for care of a patient to a second mode, the second mode using different parameters than the first mode to control elements of the infusion pump.

MEDICAL DEVICE WITH ADAPTIVE CORRECTION FOR UNCONTROLLABLE DELIVERY CONDITIONS

Resumen de: EP4772212A2

0001 An infusion device is configured to monitor delivery conditions associated with a medication infusion, identify an infusion set used with the infusion device, determine that the delivery conditions modify operation of infusion set, and determine correction factors for modifying an operation of the device based on a modification of the operation of the infusion set by the monitored delivery conditions. According to various implementations, an operating parameter of the infusion device may be modified, including modifying a threshold for when the infusion device will experience an alarm condition.

一种化合物在制备骨组织工程支架中的应用

Resumen de: CN122342853A

本发明属于生物医学技术领域，具体涉及一种化合物在制备骨组织工程支架中的应用，其特征在于，所述化合物的结构式为：其中，x和y为任意正整数。本发明具有细胞相容性高和生物安全性高的优点。

整形外科用膝関節プロテーゼ

Resumen de: WO2024251877A1

The invention relates to an orthopaedic knee joint prosthesis (2) having a metallic femoral implant part (4), a metallic tibial implant part (6) and a meniscus replacement part (8); according to the invention, it is proposed that the femoral implant part (4) and in particular also the tibial implant part (6) are manufactured additively by metallic 3D printing, that the femoral implant part (4) and/or the tibial implant part (6) have/has a three-dimensionally porous surface structure (30, 32) formed by the 3D printing, in surface regions (10, 16) facing the bone, to allow incorporation of the bone into the implant part (4, 6), and that the femoral implant part (4) and/or the tibial implant part (6) have/has at least in some areas a coating (52, 54) in surface regions (14, 20) not in contact with the bone and not in contact with the meniscus replacement part (8) but in contact with soft tissue, by means of which coating a surface roughness of these surface regions (14, 20) is reduced.

一种牙科种植体仿生支架

Resumen de: CN122342642A

本发明提供一种牙科种植体仿生支架，包括主体支架、设于主体支架边侧的固定翼，所述固定翼开设有固定孔，以使可吸收固定钉穿设于固定孔中将所述主体支架定位于牙槽骨，所述主体支架位于牙槽骨与种植体之间，且所述主体支架靠近种植体的一侧设有阵列设置的若干沟槽，所述沟槽用于引导并约束纤维细胞；本发明可极大的简化替代自体根片的制备难度，防止自体根片破碎、穿孔等导致并发症的问题。

改善された耐水性を有する印刷インク堆積物をケラチン物質に提供する方法

Resumen de: JP2026112444A

【課題】改善された耐水性を有する一時的な印刷インク堆積物をケラチン物質に提供する新規な方法を提供すること。【解決手段】本発明は、(i)任意選択により、ケラチン物質上にプライマー組成物を適用して、ケラチン物質上にプライマー層を提供する工程と、(ii)工程(i)が実施される場合にはプライマー層上に、又は工程(i)が実施されない場合にはケラチン物質上にインク組成物を適用して、プライマー層又はケラチン物質上に、インクデザインを提供する、好ましくはインクデザインを印刷する工程と、(iii)インクデザイン上に、好ましくは、印刷されたインクデザイン上に無水組成物を適用して、インクデザイン上にコーティング層を提供する工程とを含む、方法であって、無水組成物が少なくとも1種の油溶性皮膜形成剤を含む、方法に関する。本発明による方法は、改善された耐水性を有するデザインを作り上げることができる。【選択図】なし

Method for producing a thermoplastic, biodegradable, and bioactive chitosan nanocomposite

Resumen de: PL450867A1

Przedmiotem zgłoszenia jest sposób otrzymywania termoplastycznego, biodegradowalnego i bioaktywnego, nanokompozytu chitozanowego, który polega na tym, że otrzymuje się ester hydroksykwasu (aminokwasu) zawierającego co najmniej jedną grupę aminową, jedną hydroksylową i jedną grupę karboksylową oraz nasyconego kwasu tłuszczowego o parzystej liczbie atomów węgla C6 — C12 w cząsteczce, a następnie szczepi nim chitozan pochodzenia biologicznego i/lub biotechnologicznego w polu promieniowania mikrofalowego, tworzy kompozyt z PLA, nanocząstkami tlenku cynku i hydroksyapatytu na drodze współstrącania w wodzie roztworów acetonowych, a następnie oddziela, suszy i wytłacza do postaci filamentu, folii lub granulatu.

身体分析システム、身体分析システムを用いた臓器培養システム、及び身体分析プログラム

Resumen de: JP7884308B1

【課題】個人の身体の状態が正確に反映された３Ｄモデルを生成し、個人に最適化された治療シミュレーションや臓器移植を実現する身体分析システム、身体分析システムを用いた臓器培養システム、及び身体分析プログラムを提供する。【解決手段】個人の身体の状態を示す身体データを取得する身体データ取得手段と、前記身体データ取得手段により取得された前記身体データに基づいて、前記個人の分子、細胞、組織、血管、神経、又は臓器を表す３Ｄモデルを生成する３Ｄモデル生成手段とを備え、前記３Ｄモデル生成手段は、身体データを入力データとし、前記入力データに対応する３Ｄモデルを出力データとする学習データに基づいて学習されたＡＩモデルに前記身体データ取得手段により取得された前記身体データを入力し、前記３Ｄモデルを生成することを特徴とする。【選択図】図２

一种3D打印补偿膜的制作方法、系统、设备及介质

Resumen de: CN122323552A

本发明公开一种3D打印补偿膜的制作方法、系统、设备及介质，属于补偿膜制作技术领域。包括获取患者的医学影像数据，并提取覆盖放射治疗靶区上方的皮肤表面轮廓作为感兴趣区域；利用本地部署的AI智能体对所述感兴趣区域的补偿组织进行自动化建模，将所述补偿组织对应的多面体网格结构转化为具备灌注底座和开口结构的模具实体模型；将所述模具实体模型导入切片软件，根据模具壁厚参数进行水平方向的尺寸向外补偿，并生成打印指令以通过3D打印设备输出中空的补偿膜模具；向所述补偿膜模具内灌注组织等效材料，待凝固后拆除所述补偿膜模具，获得与患者皮肤表面镜像契合的补偿膜实体。本发明解决了补偿膜不贴和患者轮廓的技术问题。

一种同步调节糖脂共病的4D打印吞咽友好药食同源凝胶及其制备方法

Resumen de: CN122320863A

本发明公开了一种同步调节糖脂共病的4D打印吞咽友好药食同源凝胶及其制备方法，属于药食同源产品技术领域。本发明从“糖脂共病”的复杂病理机制出发，基于“药食同源”理论和现代系统生物学思想，筛选六味药食同源原料（黄芪、葛根、桑叶、玉米须、山药、紫苏）按特定配比组合，通过多靶点、多通路协同发挥降糖降脂作用；在此基础上，进一步明确其核心活性成分为槲皮素、木犀草素和山奈酚，构建从原料组合到活性成分的4D打印保护体系。

一种可降解非均质载药支架

Resumen de: CN122320718A

本申请提供了一种可降解非均质载药支架，包括由可降解材质制成的轴向投影呈C字形的筒状支架主体，支架主体包括高模量结构支撑外层、同轴设置的低模量弹性内层、若干贯穿外层与内层的工形柱以及设于外层与内层之间的载药模块；内层设有收缩区与缓释区，配合劲度系数不一致的弹性件组合可实现支架主体局部径向仿生自适应形变功能；载药模块含多尺寸贯通药腔，通过缓释孔实现药物分量、分类、分时可控释放，结合药物涂层与药物微球形成协同载药；同时增设多重锚定结构与柔性过渡段提升位置稳定性、抗移位能力。本申请载药支架可适配气管特定生理环境，药物释放可控，术后结构与位置稳定，具备显著临床应用价值。

基于连续折叠薄片的支架

Resumen de: WO2025117862A1

Provided herein are various embodiments related to the design, creation, and use of a folded sheet scaffold for medical devices. The scaffold comprises a shellular porous pseudorandom orientable architecture composed of a continuous folded sheet of topological genus-n. Methods for designing the scaffold involve driving noise from an infinite 3D noise field to define a field with real space, tuning field values based on user input, and subtracting to create thin wall geometry. The methods can be computer-implemented or executed by a processor following instructions stored on a non-transitory computer-readable medium. A computer system for designing the scaffold includes modules for noise-driving, tuning, and subtracting. The disclosure also includes a folded sheet scaffold formed by these methods and a medical device comprising the folded sheet scaffold.

一种珊瑚骨3D打印“三明治”仿生支架、其制作方法及应用

Resumen de: CN122321219A

本发明提供一种珊瑚骨3D打印“三明治”仿生支架、其制作方法及应用，涉及3D仿生支架技术领域。本发明通过在“三明治”仿生支架中构建KGN与珊瑚骨双物质三浓度梯度分布，通过在各层的孔径结构设置梯度差异，可对不同区域骨髓间充质干细胞实现募集、特异性诱导分化，为骨软骨一体化修复提供兼具结构仿生、生物活性与功能可控的理想解决方案。

一种适用于体积生物打印的微凝胶生物墨水及应用

Resumen de: CN122321220A

本发明公开了一种适用于体积生物打印的微凝胶生物墨水及应用，该生物墨水由微凝胶和光交联聚合物溶液和光引发剂混合制成，其中，光交联聚合物溶液在生物墨水中的终浓度扩展至1.25%‑20%，制得的生物墨水均可在绿光下实现交联，且具有良好的打印性。将该生物墨水应用在负载细胞的生物打印中，可用于构建具有通道和/或异质细胞结构的组织或器官；由于无接触式和3D立体成型打印，避免了细胞在传统挤出打印过程中剪切力的损害，且可在数十秒内完成打印过程，从而实现较高的生物打印细胞活性。

一种脱细胞基质微粒3D打印墨水及其制备方法与应用

Resumen de: CN122321228A

本发明涉及生物医学材料技术领域，具体涉及一种脱细胞基质微粒3D打印墨水及其制备方法，其技术要点是：通过过饱和溶液重结晶方式在脱细胞基质微粒（dECM‑MPs）表面暂覆溶解吸热型化合物，然后将其浸入温敏的明胶溶液中，通过溶解吸热型化合物在溶解过程中吸热导致微球周围局部低温，使明胶凝固在dECM‑MPs表面，原位生成物理固化的明胶水凝胶微层，并进一步酶交联稳定水凝胶微层。在水凝胶微层中引入光敏改性的透明质酸分子调控微层机械性能。经离心处理制得可用于挤出式3D打印的颗粒墨水，3D打印后进一步利用紫外光线辐照制得3D打印植入物，本发明可以克服刚性dECM‑MPs如脱细胞软骨微粒或脱细胞骨微粒等无法挤出打印的问题，通过水凝胶微层机械性能调控可以获得具有优异打印性能的颗粒墨水。该方法克服了刚性组织难以增材制造的局限。

一种牙支持式下颌骨升支矢状劈开截骨的个体化下颌神经定位及保护导板

Resumen de: CN122320640A

本发明涉及一种牙支持式下颌骨升支矢状劈开截骨的个体化下颌神经定位及保护导板，包括牙支持固定结构、导板主体结构、下颌神经定位结构、截骨引导结构和神经保护结构，所述牙支持固定结构的内表面形态与患者牙列外形相匹配，通过覆盖牙冠的方式与牙列形成稳定的三维定位关系，所述导板主体结构一端连接所述牙支持固定结构、另一端连接所述神经保护结构并分别以下颌神经定位结构向上延伸至下颌升支区域、以截骨引导结构延伸至下颌体部区域，所述下颌神经定位结构设置在所述导板主体结构的相应位置并根据术前CT影像数据重建的下颌神经管位置及走形进行标记，所述下颌神经定位结构对应下颌骨升支矢状劈开截骨的内侧截骨线位置，所述截骨引导结构对应下颌骨体部截骨的纵向截骨线位置。

3D打印定制化骨科脊柱术后体位支撑护理装置

Resumen de: CN122320728A

本发明公开了一种3D打印定制化骨科脊柱术后体位支撑护理装置，包括支撑板、穿戴组件、防护囊、控制盒和供电组件，所述支撑板为基于患者脊柱CT/MRI影像数据3D打印的定制化硬质支撑结构，其外轮廓贴合患者背部脊柱生理曲度及体型特征，表面均匀分布透气孔；包括肩带、护腰及腰带，所述肩带对称设置于支撑板上部两侧，所述护腰设置于支撑板下部，所述腰带设置于护腰外侧，用于将支撑板稳定固定于患者背部；所述防护囊贴合设置于支撑板内侧，通过魔术贴或卡扣与支撑板可拆卸连接。本发明的有益效果在于：可避免硬质支撑板直接压迫手术切口及周围软组织；充气部独立腔室可根据患者需求精准调节充气压力，适配不同活动状态与康复阶段。

BED POSITION CONTROL DEVICE, BED POSITION CONTROL METHOD, AND RADIOTHERAPY DEVICE

Resumen de: WO2026141016A1

The present invention enables more efficient positioning control of a bed on which a patient is placed. A bed position control device that controls a position of a bed on which a patient is placed includes: an image acquisition unit that acquires a fluoroscopic X-ray image obtained by imaging the patient by X-ray fluoroscopy; a pseudo fluoroscopic X-ray image acquisition unit that acquires a pseudo fluoroscopic X-ray image created from a three-dimensional image of the patient; a second region-of-interest creation unit that, from a first region-of-interest set in the pseudo fluoroscopic X-ray image so as to include a region of a target structure, creates a second region-of-interest including the region of the target structure in accordance with a positional deviation of the patient; and an image matching unit that matches an image in the second region-of-interest in the pseudo fluoroscopic X-ray image with an image in the second region-of-interest in the fluoroscopic X-ray image, determines a position of the bed necessary for aligning the position of the patient in the fluoroscopic X-ray image, and moves the bed to the determined position of the bed.

Immunotherapy methods for patients whose tumors carry a high passenger gene mutation burden

Resumen de: AU2026204455A1

Methods for selecting a cancer patient for immunotherapy comprise establishing a total passenger gene mutation burden from a tumor of a cancer patient, generating a background distribution for the mutational burden of the tumor, normalizing the total passenger gene mutation burden against the background distribution, and categorizing the cancer patient as an immunotherapy responder when the total passenger gene mutation burden is greater than the mean of the background distribution. When the cancer patient is an immunotherapy responder, the patient may be administered an immunotherapy regimen that comprises activation/inhibition of T cell receptors that promote T cell activation and/or prolong immune cytolytic activities. un u n e t h o d s f o r s e l e c t i n g a c a n c e r p a t i e n t f o r i m m u n o t h e r a p y c o m p r i s e e s t a b l i s h i n g a t o t a l p a s s e n g e r g e n e m u t a t i o n b u r d e n f r o m a t u m o r o f a c a n c e r p a t i e n t , g e n e r a t i n g a b a c k g r o u n d d i s t r i b u t i o n f o r t h e m u t a t i o n a l b u r d e n o f t h e t u m o r , n o r m a l i z i n g t h e t o t a l p a s s e n g e r g e n e m u t a t i o n b u r d e n a g a i n s t t h e b a c k g r o u n d d i s t r i b u t i o n , a n d c a t e g o r i z i n g t h e c a n c e r p a t i e n t a s a n i m m u n o t h e r a p y r e s p o n d e r w h e n t h e t o t a l p a s s e n g e r g e n e m u t a t i o n b u r d e n i s g r e a t e r t h a

INFORMATION PROCESSING DEVICE, INFORMATION PROCESSING METHOD, AND RECORDING MEDIUM

Resumen de: WO2026140078A1

This information processing device comprises: an acquisition means for acquiring, on the basis of a camera image generated by a camera provided at a position where a specific body part of a pedestrian serving as an imaging target can be imaged and distance information from the position of the specific body part to the camera, transition information that indicates the transition of the position of the specific body part in the three-dimensional space; an angle estimation means for estimating, on the basis of the transition information, a camera angle which is an angle formed by the optical axis of the camera and an axis parallel to the traveling direction of the pedestrian; a position estimation means for estimating the transition of the positions of the eyes of the pedestrian on the basis of the transition information and the camera angle; and an image acquisition means for acquiring, on the basis of the estimated transition of the positions of the eyes, an eye image obtained by imaging the eyes.

ORTHOPAEDIC PLANNING SYSTEMS AND METHODS OF REPAIR ASSOCIATED WITH EROSION

Nº publicación: US20260183125A1 02/07/2026

Solicitante:

ARTHREX INC [US]
ARTHREX, INC.

Resumen de: US20260183125A1

0000 This disclosure relates to planning systems and methods associated with erosion along an articular surface of a joint. The planning systems and methods disclosed herein may be utilized for planning orthopaedic procedures to restore functionality to a joint, may include determining an amount of erosion along or otherwise adjacent to an articular surface of a bone. One or more spherical objects may be utilized to determine the erosion.