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STEREOLITHOGRAPHIC RESIN COMPOSITION

Resumen de: WO2025100441A1

The present invention provides a stereolithographic resin composition which is excellent in modeling accuracy, strength, toughness, and water resistance of a modeled article, and has little eluate from a modeled article. The present invention relates to a stereolithographic resin composition that contains a polyfunctional (meth)acrylic polymerizable compound (A) and a photopolymerization initiator (B) containing four or more heteroatoms per molecule. The stereolithographic resin composition preferably also contains a monofunctional (meth)acrylic polymerizable compound (C). The polyfunctional (meth)acrylic polymerizable compound (A) preferably contains a polyfunctional (meth)acrylic polymerizable compound (A)-I having a molecular weight of less than 500.

A SHRINKING AND SETTING BIOINK

Resumen de: WO2025099720A1

Provided is a hybrid hydrogel composition and methods for its preparation and use in 3D printing biomaterials for tissue engineering applications. The hybrid hydrogel composition comprises discrete hydrogel particles of a first crosslinked polymeric network, interpenetrated- through and threaded by a second crosslinked polymeric network, dispersed in a medium. The first polymer is a thermo-responsive polymer, while the second is a protein-based thermo¬ denaturing polymer. The process for preparing this composition involves mixing swelled hydrogel nanoparticles of the first polymer with a non-crosslinked hydrogel of the second polymer in the presence of a crosslinking agent for the first polymer. The 3D printing method utilizes this composition below the LCST of the thermo-responsive polymer, followed by temperature increase wherein the second polymer cures and fixes the printed ink. This approach enables the creation of high-resolution structures, including artificial tissues with capillary blood vessels, featuring dimensions less than 50 μm.

SYSTEMS AND METHODS FOR PRINTING HIGH-DENSITY TISSUE FIBERS

Resumen de: WO2025099487A1

Aspects of the disclosure include microfluidic print heads for bioprinting core/shell fibers having consistent diameters and shell thicknesses, and methods of making high-density tissue fibers comprising cell populations of therapeutic interest for implantation, as well as the high-density tissue fibers produced thereby.

CRYOPRESERVATION OF BIOPRINTED TISSUE FIBERS

Resumen de: WO2025099488A1

Aspects of the disclosure include cryopreserved tissue fibers and multilayer structures comprising said fibers, wherein the fibers encapsulate dissociated cells, and where the fibers and/or structured are cryopreserved prior to aggregation of the encapsulated cell population. Methods of making and using such fibers and structures are also provided.

DEVICE FOR TREATING SNORING AND APNEA

Resumen de: WO2025097229A1

The present invention relates to a dental device for treating snoring and apnea (1) which is made using a 3D digital model and 3D printers and is composed of an upper plate (4) and a lower plate (6) that are joined by interlocking mechanisms (8, 9) that limit the opening of the mouth, optimizing the results of the treatment for snoring and apnea. The device is an apparatus for bringing the lower jaw forward that does not contain metal elements incorporated into the design of the apparatus, making manufacture easier and cheaper, as well as making the device more hygienic. Additionally, the forward movement of the lower jaw (7) is not achieved using screws or metal wires, but rather by sequentially and incrementally changing the plates, thus increasing the caliber of the airways, wherein the forward movement results from changes in the positioning of the interlocking mechanisms (8, 9).

RADIATION-CURING COMPOSITION FOR PRODUCING DENTAL COMPONENTS IN A 3D PRINTING PROCESS

Resumen de: WO2025099123A1

The invention relates to a radiation-curing composition for producing dental components in a 3D printing process, comprising, based on the total mass of the radiation-curing composition: i) one or more radically polymerisable monomers in a combined mass fraction of 30% or more; ii) one or more first fillers in a combined mass fraction of 5% or more, wherein the first filler or fillers has or have an average particle diameter D50 of 150 nm or less; iii) one or more second fillers, different from the first filler, in a combined mass fraction of 5% or more, wherein the second filler or fillers is or are selected from the group consisting of feldspars; and iv) one or more photoinitiators having a combined mass fraction in the range of 0.001 to 10%, wherein the combined mass fraction of fillers is 30% or more.

Partially Porous Tibial Component

Resumen de: US2025152374A1

A method for removing a stem portion of an orthopedic implant from a bone comprises exposing an implanted orthopedic implant having a body portion, a stem portion interconnected to the body and a porous metal section forming an interconnection between the body and the stem portion. A cutting tool is mounted on a holder connected to an exposed surface of the orthopedic implant. The porous section is aligned with the cutting tool mounted on the holder. The entire porous section is cut by moving the cutting tool therethrough in a direction transverse to the stem portion axis. The implant body portion is then removed and then the stem portion is removed from the bone. The cutting tool may be a saw or chisel which may be mounted on a guide fixed to the body portion.

SYSTEMS AND METHODS TO REPAIR TISSUE DEFECTS

Resumen de: US2025151975A1

Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.

CONTINUOUS LIQUID INTERPHASE PRINTING

Resumen de: US2025152925A1

A method of forming a three-dimensional object is carried out by providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; filling the build region with a polymerizable liquid; irradiating the build region through the optically transparent member to form a solid polymer from the polymerizable liquid and advancing the carrier away from the build surface to form the three-dimensional object from the solid polymer, while also concurrently with the irradiating and/or advancing steps: (i) continuously maintaining a dead zone of polymerizable liquid in contact with the build surface, and (ii) continuously maintaining a gradient of polymerization zone between the dead zone and the solid polymer and in contact with each thereof. The gradient of polymerization zone comprises the polymerizable liquid in partially cured form (e.g., so that the formation of fault or cleavage lines between layers of solid polymer in the three-dimensional object is reduced). Apparatus for carrying out the method is also described.

HYBRID 3D PRINTER HAVING DISPENSER WITH MOVABLE LIGHT SOURCE

Resumen de: US2025153425A1

A method of three-dimensional (3D) printing includes heating a photo-curable material and extruding the photo-curable material from a nozzle of a dispenser to form a first layer of an object according to a digital file, wherein the first layer has a first shape specified by the digital file, and wherein the first shape has a first minimum line width based on a diameter of the nozzle. The method further includes directing a light beam onto the first layer according to the digital file or an additional digital file to cure a portion of the first layer, wherein the cured portion of the first layer has a second shape, wherein the second shape may comprise features that are smaller than the first shape. The light source is attached to the dispenser and is movable to adjust a direction of the light beam relative to the nozzle of the dispenser.

MONOMERIC AND POLYMERIC COMPOSITIONS AND METHODS OF PRODUCING AND USING THE SAME

Resumen de: US2025154305A1

The present disclosure provides photo-polymerizable monomers, photo-curable resins comprising one or more of such monomers, as well as polymeric materials formed from the photo-curable resins. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

ON-THE-FLY MOLDING

Resumen de: US2025153399A1

A method of fabricating an object from a heat curable polymer such as silicone is provided. The method is carried out by using additive manufacturing to fabricate a portion of a mold and filling the portion of the mold with the heat curable polymer. The polymer is then heated and the steps of mold fabrication and filling are repeated until the object is fabricated.

FABRICATION OF DENTAL APPLIANCES FROM PHASE-SEPARATED COMPOSITIONS

Resumen de: US2025154307A1

Methods for fabricating orthodontic appliances are provided. In some embodiments, a method includes: providing a polymerizable composition, the polymerizable composition including an initial ratio of a first polymerizable component to a second polymerizable component; and applying a holographic pattern of radiation to the polymerizable composition to form a portion of an orthodontic appliance. The portion can include: a first region including a first ratio of the first polymerizable component to the second polymerizable component, the first ratio being different from the initial ratio; and a second region including a second ratio of the first polymerizable component to the second polymerizable component, the second ratio being different from the initial ratio and the first ratio.

Porous Structures Produced By Additive Layer Manufacturing

Resumen de: US2025153427A1

A three-dimensional structure is formed when layers of a material are deposited onto a substrate and scanned with a high energy beam to at least partially melt each layer of the material. Upon scanning the layers at predetermined locations at least a first segment overlapping a second segment and underlapping a third segment is formed.

3D Segmented Cranial Correction Helmet Using 3D Printing

Resumen de: KR102807975B1

본 발명은 착용자의 두상에 맞게 헬멧의 외피와 내피를 교체할 수 있도록 설계된 헬멧으로,헬멧의 경질 외피와 체결 구조를 통해 착용 중 안정성을 유지하면서도 두상 교정이 가능하도록 고안된 3D 프린팅 기반의 장치에 관한 것으로, 착용자의 머리 전단을 덮고 안착되는 3D 프린팅을 이용하여 제작되는 경질의 제1 외피부; 상기 제1 외피부의 후단에 맞물려 체결되며, 착용자의 머리 후단을 덮고 안착되는 3D 프린팅을 이용하여 제작되는 경질의 제2 외피부; 상기 제1 외피부와 상기 제2 외피부의 각 측면 사이에 설치되어 상기 제1 외피부와 상기 제2 외피부를 상호 체결하는 외피 체결부; 착용자의 두상 교정을 위해 상기 제1 외피부의 내향면에 설치되는 연질의 제1 내피부; 착용자의 두상 교정을 위해 상기 제2 외피부의 내향면에 탈부착 가능하도록 설치되는 연질의 제2 내피부; 및 착용자의 두상이 커짐에 따라 보다 작은 두께로 교체 가능하도록 상기 제2 외피부와 상기 제2 내피부 사이에 설치되는 다양한 두께로 구비되는 중간부;를 포함한다.

METHOD FOR PREPARING HOMOGENEOUS COLLAGEN SUSPENSION, USE OF HOMOGENEOUS COLLAGEN SUSPENSION, METHOD FOR PREPARING COLLAGEN-BASED HYDROGEL MATERIALS, METHOD FOR PREPARING COLLAGEN FILM AND/OR LAYER AND/OR SUBSTRATE FOR CULTURE, METHOD FOR PREPARING COLLAGEN PRINT-OUTS, AND METHODS FOR PREPARING POROUS COLLAGEN SHAPES

Resumen de: EP4553104A1

An object of the invention is a method for obtaining a homogeneous collagen suspension, characterized in that it comprises the following stepsI. to collagen, with mixing, preferably on a vortex, a solution composed of a mild organic solvent and a buffer, with the addition of acids is added wherein:- as the collagen preferably type I collagen is used, preferably it is the collagen derived from bovine tendons,- the concentration of the collagen with respect to the solvent is in the range of 0.1 to 15% w/v,- the organic solvent is a solvent exhibiting low surface tension relative to the collagen, preferably the solvent is a solvent for which the contact angle value for collagen is below 20°, most preferably the organic solvent is dimethyl sulfoxide (DMSO),- the buffer is a buffer containing salts naturally occurring in a living organism, preferably the buffer is a phosphate buffer (PBS),- the solvent and the buffer can be mixed together in various proportions, preferably the solvent and the buffer are mixed in a ratio of 5 parts of the solvent to 1 part of the buffer, by volume, most preferably 5 parts DMSO to 1 part PBS, by volume,- the acids are HCl and HF, wherein the concentration of each of the acid in the solution is not higher than 0.1 M,II. subsequently, the solution obtained in step I. is mixed at a temperature of 2 - 8°C, preferably 4 - 6°C, for a period of 3 to 7 days, preferably for a period of 3 days,III. subsequently, the solution obtained in step II., while mix

PARTIALLY TRABECULAR ELEMENT FOR AUGMENT OR BONE FILLER

Resumen de: AU2023303676A1

Element (100, 200, 300) for augment or bone filler, comprising at least one first outer-layer portion (101) having a trabecular lattice of metallic material, and further comprising at least one reinforcing inner layer (103) of metallic material having a plurality of channel structures (104) arrayed with respective channel openings (105) delimited by edges in structural contact with the at least one first outer-layer portion (101).

3D PRINTABLE MATERIAL FOR THE FABRICATION OF PRINTED DENTAL ATTACHMENTS AND DENTAL ATTACHMENT PLACEMENT DEVICES

Resumen de: US2024016579A1

Disclosed herein are dental attachment placement devices generated from curable compositions by additive manufacturing. The curable compositions contain a high crosslinker content, and after curing, yield tough and color neutral materials suitable for dental attachment placement devices.

BIOGLASS FIBER REINFORCEMENT OF ADDITIVELY MANUFACTURED POLYMERS

Resumen de: US2024016578A1

Disclosed herein are methods for manufacturing medical devices, such as implants, joint replacements, graft materials, augmentation materials, prosthetic materials, etc., from solid material reinforced curable resins. Methods of repositioning a patient's teeth using such medical devices are also provided.

METHOD FOR MANUFACTURING TRANSPARENT ORTHODONTIC DEVICE BY USING 3D PRINTER

Resumen de: EP4552608A1

This invention provides a more efficient, cost-effective, and streamlined method for manufacturing transparent orthodontic devices by utilizing 3D printing technology. It simplifies the production process, reduces collaboration time, and ensures that the aligners are customized for the patient's specific orthodontic needs.

一种用于细胞3D打印的高强度光敏生物墨水水凝胶及其制备方法

Resumen de: CN119971134A

本发明涉及一种用于细胞3D打印的高强度光敏生物墨水水凝胶及其制备方法，属于生物材料技术领域。该方法直接采用高强度材料NAGA为生物墨水水凝胶提供高强度，通过3D打印载细胞生物活性墨水，实现生物活性和高强度的兼顾。并在绿光下进行交联以避免光照对细胞的损伤，通过在生物墨水中抗氧化剂以避免光引发剂产生的自由基对细胞的攻击，最终实现用于细胞3D打印的高强度光敏生物墨水水凝胶制备。本发明制备得到的生物墨水水凝胶，可以实现高的力学性能和生物(细胞)活性的兼顾，有效的避免紫外光对于细胞的损伤，解决了长时间光照下光引发剂产生的自由基对细胞的损伤的问题。

一种使用3DFP增材制造的具有梯度结构的生物陶瓷骨支架制备方法

Resumen de: CN119977560A

本发明公开了一种使用3DFP增材制造的具有梯度结构的生物陶瓷骨支架制备方法；包括：设计生物梯度结构模型；配备包含纳米氧化锆、磷酸三钙、羟基磷灰石和氧化银粉末的丝材原料，混合制浆，制备丝材；将制备的丝材加入打印机中，按切片路径完成梯度结构的逐层打印，获得支架坯体；热处理，之后随炉冷却至室温，即得所述生物陶瓷骨支架。本发明通过深层次优化丝材原料的组成配比，提升支架材料的机械强度；与此同时通过成分梯度和结构梯度双重设计，在保证密质骨高强度、硬度、抗弯性的基础上内层设计成分与结构不同的松质骨，借此来保证支架与组织或细胞有效地相互作用，促进骨细胞的黏附、增殖和分化，有助于组织修复和再生。

一种生物陶瓷支架及其制备方法和应用

Resumen de: CN119977543A

本发明提供了一种生物陶瓷支架及其制备方法和应用，属于组织修复材料技术领域。本发明通过DLP光固化3D打印技术，将具有与人体骨相近的抗压强度以及适中的降解速率的镁黄长石，设计出了一种用于提升骨组织修复的生物陶瓷支架，且机械强度和孔隙率及支架结构满足骨修复支架要求。本发明利用DLP光固化3D打印技术制备了一种新型多孔生物陶瓷支架，探索了支架形态、固含量、烧结参数对骨修复支架机械性能的影响，最终制备得到机械性能高的骨修复效果优异的生物陶瓷支架。

用于利用眼透镜控制轴向生长的装置和方法

Resumen de: US2024408834A1

One embodiment of an ocular lens includes a lens body configured to contact an eye where the lens body has an optic zone shaped to direct central light towards a central focal point of a central region of a retina of the eye. At least one optic feature of the lens body has a characteristic that directs peripheral light off axis into the eye away from the central region of the retina. Another embodiment of an ocular lens has at least one isolated feature of the lens body that has a characteristic of directing peripheral light off axis into the eye away from the central region of the retina. Methods of making contact lenses include forming the features during the manufacturing process.

用于简化口腔骨增量手术4D打印支架的制备方法及应用

Nº publicación: CN119971138A 13/05/2025

Solicitante:

吉林大学

Resumen de: CN119971138A

本发明适用于口腔种植学技术领域，提供了用于简化口腔骨增量手术4D打印支架的制备方法及应用。本发明利用4D打印技术，将聚多巴胺和海藻酸钠混合打印成水凝胶支架，经锶离子交联后，该支架展现出优异的生物可降解性和生物相容性，可替代钛网弯曲支架，有效维持成骨空间，并降低种植骨增量手术的高技术敏感度。该支架能精准适配不同骨缺损轮廓，提供支撑并加速愈合，降低并发症风险。其适配性强、植入简便，能最大程度减少不必要的组织剥离与损伤，缩短手术时长，利于患者术后恢复。在水平骨增量手术中，该支架能为后续牙种植等修复手段提供坚实的骨基础。形变产生的机械信号与支架释放的生物活性成分协同作用，加快骨组织再生。