Alerta

MATERIAL AND METHOD FOR PRODUCING CELL RECEIVING SCAFFOLD

Resumen de: EP4628303A2

A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt% to about 3.0 wt% of one or more collagens; about 5.0 wt% to about 40.0 wt% of one or more monomers; about 0.5 wt% to about 2.0 wt% of a photo initiator; and 0 wt% to about 75 wt% of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm² (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.

DENTAL IMPLANTS WITH CORONAL FEATURES AND SYSTEMS, DEVICES, AND METHODS FOR DESIGNING AND MANUFACTURING SAME

Resumen de: WO2024145635A2

Root-analog dental implants include one or more coronal grooves that are sized, shaped, and/or configured to correspond to a size, shape, and/or position of a bone crest for an extracted tooth a root-analog dental implant is designed and manufactured to replace. The coronal grooves may be configured to engage with bone of an alveolar socket to enhance engagement between the root-analog dental implant and the alveolar socket particularly for the time period following seating the root-analog dental implant within the socket site and prior to osseointegration of the root-analog dental implant with the alveolar socket. This promotes stability of the root-analog dental implant within the socket site immediately following insertion and thereafter, which may decrease movement of the root-analog dental implant within the socket site, decrease a likelihood of foreign material such as bacteria or food entering the socket site, and/or reduce a risk of implant failure and jawbone injury.

HYDROGEL COMPOSITION FOR 3D PRINTING, AND 3D PRINTING HYDROGEL PREPARED THEREFROM

Resumen de: EP4644440A1

The present invention relates to a hydrogel composition for 3D printing, and a 3D printing hydrogel formed using the same, hydrogel composition comprising an acrylamide-based compound, a hydrophilic thickener, an alkali compound and a solvent.

LIQUID WITH PATTERN AND PRODUCTION METHOD FOR SAME

Resumen de: EP4643651A1

The present invention aims to provide a pattern-containing liquid that contains, in a liquid matrix, a pattern that can provide color, taste, or tactile sensations such as mouthfeel and texture, and that has good stability, as well as a method for producing a pattern-containing liquid capable of stably forming the above pattern in a liquid matrix. The present invention relates to, for example, a pattern-containing liquid containing a pattern formed from at least one of a microparticulate or a colorant in a liquid matrix, the liquid matrix being a pseudoplastic fluid and contained in a container.

ORTHODONTIC APPLIANCES AND METHODS OF MANUFACTURING

Resumen de: EP4643810A1

Orthodontic appliances are disclosed, comprising an integrally formed shell including a first shell part comprising one or more first cavities adapted to receive the first teeth of the patient, a second shell part comprising one or more second cavities adapted to receive the second teeth of the patient, and a modified active shell part connecting the first shell part and the second shell part, and wherein the modified active shell part comprises one or more active elements configured to apply forces to the first and/or the second shell part. The disclosure further relates to methods for manufacturing an orthodontic appliance, to computer-implemented methods for generating an input file for a 3D printer and to kits comprising series of consecutive shells.

HINGE MECHANISM FOR A KNEE ORTHOSIS, PROCEDURE FOR FITTING A HINGE MECHANISM, AND A KNEE ORTHOSIS

Resumen de: EP4643829A1

The invention is related to the technical field of orthopedic devices, in particular knee orthoses for supporting a knee joint, and more specifically of an orthopedic device with a hinge, wherein the movement of the device can be limited by means of the hinge and where the hinge of the device is formed via 3D printing so that a knee orthosis can be made to measure for the patient and where a minimum of different parts is required for the assembly of the knee brace. The invention also includes a method for installing such hinge mechanisms and a knee orthosis provided with such hinge mechanisms.

FERROMAGNETIC SKIRT FOR A MEDICAL DEVICE

Resumen de: WO2024163373A1

An implantable medical device includes a wire frame, a cover, and a sensor. The wire frame is formed of struts and openings. The cover connects to the struts of the wire frame. The cover is fashioned from a fabric including a PET fabric made of PET yarn and a ferromagnetic material combined with the PET fabric. The PET yarn is made from a plurality of PET fibers. The sensor is positioned on the cover and connected to the wire frame. The cover shields the sensor from detuning effects of the wire frame.

DEVICES AND METHODS FOR POST-PROCESSING ADDITIVE-MANUFACTURED WORKPIECES

Resumen de: WO2024141861A1

Post-processing devices for post-processing additive-manufactured workpieces and methods thereof are described. Sequential cleaning and post-curing under vacuum may be accomplished within a single device. The post-processing device (100, 200A, 400) comprises: a chamber (102, 202, 402) comprising an inlet (104, 204, 404) configured to be in communication with a vacuum source, and an electrical outlet configured to be in communication with a power source; a spinning platform (108, 208, 308, 408) for retaining a plurality of workpieces (222), a rotating drive apparatus (118, 218, 418) for rotating the spinning platform; a collection vat (116, 216, 416) surrounding the spinning platform; and one or more post-curing light source (120, 220, 420); wherein the spinning platform, the rotating drive apparatus, and the collection vat, are housed within the chamber.

3D PRINTING COMPOSITION FOR BIOMATERIALS

Resumen de: EP4644125A2

A 3D printing resin composition for a biomaterial and method for 3D printing the composition, wherein the composition comprises:(i) a pre-polymer comprising a polymeric unit of the general formula (-A-B-)_n, wherein A represents a substituted or un-substituted ester, B represents a substituted or un-substituted acid ester comprising at least two acid ester functionalities, and n represents an integer greater than 1,(ii) at least one photo-initiator, and(iii) at least one light blocker.

骨安定インプラント及び仙腸関節を横切る配置方法

Resumen de: AU2025230762A1

Abstract The invention relates to a threaded bone implant, comprising: an elongate body extending from a proximal end of the bone implant to a distal end of the bone implant, the elongate body including an inner shank, one or more threads, each of which extend radially from the inner shank and extend along at least a portion of a length of the elongate body, a porous network of interconnected struts extending radially from the inner shank and disposed and extending axially between the one or more threads, the inner shank, the one or more threads, and the porous network of interconnected struts being formed together with an additive manufacturing process such that the inner shank, the one or more threads, and the porous network of interconnected struts are integral, and wherein the porous network of interconnected struts has a greater surface area in a central region of the elongate body than in a distal region of the elongate body, wherein the central region includes a midpoint of the length of the elongate body. Abstract The invention relates to a threaded bone implant, comprising: an elongate body extending from a proximal end of the bone implant to a distal end of the bone implant, the elongate body including an inner shank, one or more threads, each of which extend radially from the inner shank and extend along at least a portion of a length of the elongate body, a porous network of interconnected struts extending radially from the inner shank and disposed and extending a

기능화된 재조합 박테리아 콜라겐-유사 단백질

Resumen de: WO2024188844A1

Recombinant bacterial collagen-like protein, preferably with an amino acid sequence that is at least ≥ 60% identical to the amino acid sequence of SEQ ID NO:1 wherein the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO:1, wherein the recombinant collagen-like protein is functionalized with at least one non-terminal alkene group. A bioink comprising the functionalized recombinant bacterial collagen-like protein, at least one solvent and at least one photoinitiator, a process for producing a hydrogel by crosslinking the functionalized recombinant bacterial protein or the bioink as well as the hydrogel obtained therefrom. Furthermore, a scaffold for tissue engineering comprising the hydrogel.

티올화된 재조합 박테리아 콜라겐-유사 단백질

Resumen de: WO2024188850A1

Recombinant bacterial collagen-like protein, preferably with an amino acid sequence that is at least ≥ 60% identical to the amino acid sequence of SEQ ID NO:1 wherein the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO:1, wherein the recombinant collagen-like protein is functionalized with at least one thiol group. A bioink comprising the functionalized recombinant bacterial collagen-like protein, at least one solvent and optionally at least one photoinitiator, a process for producing a hydrogel by crosslinking the functionalized recombinant bacterial protein or the bioink as well as the hydrogel obtained therefrom. Furthermore, a scaffold for tissue engineering comprising the hydrogel.

一种4D打印仿生假肢及其制备方法与应用

Resumen de: CN120884406A

本发明涉及一种4D打印仿生假肢及其制备方法与应用，涉及医疗康复器械技术领域，该仿生假肢包括仿生骨架和柔性驱动单元；柔性驱动单元位于仿生骨架的关节活动部位，用于驱动仿生骨架的运动；仿生假肢采用4D打印一体化成型得到，仿生骨架采用形状记忆复合材料制得，柔性驱动单元采用水凝胶驱动材料制得；形状记忆复合材料包括质量之比为(80％～95％):(5％～20％)的形状记忆聚合物和增强材料；水凝胶驱动材料包括质量之比为(50％～80％):(20％～40％):(3％～15％)的温敏性聚合物基体、稳定剂和功能性填料。本发明的4D打印仿生假肢具有动态调整能力，能够满足残肢在不同情况下的变化需求的问题。

사람의 교합 평면의 변위, 특히 영구 변위를 준비하기 위한 디바이스의 시리즈, 그리고 연관된 방법

Resumen de: US2025312125A1

A series (100) of devices for assisting in the displacement of the chewing plane of a person (P) is explained, comprisingat least two devices (10),wherein the devices (10) each comprise at least one jaw device (11, 12),wherein the at least one jaw device (11, 12) comprises an upper jaw device (11) and/or a lower jaw device (12),and wherein the devices (10) are designed to be worn by the person (P) according to a predetermined sequence.In at least one device (10.1, 10.2), the at least one jaw device (11, 12) comprises at least one height element on a first side. At least two contact areas, preferably local contact areas, are formed on the at least one height element at mutually different positions of molar elements. At least one further contact area is formed on a second side of the at least one jaw device (11, 12), in particular a further local contact area. The at least three contact areas define the plane (GE),wherein the plane (GE) deviates from a starting chewing plane of the person (P) or from a current chewing plane of the person (P) with respect to its inclination changed by the at least one height element in a frontal section or sagittal section and/or deviates with respect to its height position changed by the at least one height element, andwherein in at least one other device of the series (100) a different inclination in a frontal section or sagittal section and/or a different height position of the respective plane is adjusted by at least one further height eleme

用于牙齿矫正的透明矫治器及附件的设计方法

Resumen de: WO2024232571A1

A design method for a transparent orthodontic device and an attachment for orthodontics according to the present invention, which is devised in order to solve the technical problem as described above, is a method for designing an orthodontic device by using a computer. As a means for solving the technical problem, the method comprises: a step (S01) of designing a shape of an attachment attached to a surface of a tooth model; a step (S02) of designing an inner surface shape of a transparent orthodontic device to correspond to the shape of the attachment designed in step S01; and a step (S03) of printing the transparent orthodontic device by using a 3D printer, wherein the attachment comprises: two pressurizing surfaces (101) formed to face each other; two inclined surfaces (201) which are in contact with the two pressurizing surfaces (101) and are formed to be inclined while facing each other; an upper end surface (301) having corners, all of which are in contact with the two pressurizing surfaces (101) and the two inclined surfaces (201); and an attachment surface (401) attached to a surface of a tooth.

Self-restorative microneedle interface ant its fabrication methods

Resumen de: KR20250156917A

본 개시는 베이스부와 상기 베이스부에 돌출된 복수개의 마이크로니들을 포함하는 마이크로니들 어레이; 및 상기 마이크로니들 어레이의 전 표면에 전도성 고분자를 포함하는 전도층을 포함하며, 상기 마이크로니들 어레이는 형상기억고분자를 포함하는 것인, 마이크로니들 생체전극 및 이의 제조방법에 관한 것이다.

使用3D打印聚电解质结构作为反向牺牲模板创建用于再生医学的3D分级通道支架

Resumen de: WO2024151882A1

What is presented herein is a robust sacrificial strategy to create hierarchical and perfusable microchannel networks within versatile scaffolds via the combination of embedded 3D printing (EB3DP), tunable poly electrolyte complexes (PEC), and casting methods. The sacrificial templates of PEC filaments (diameter from 100 to 500 pm) with arbitrary 3D configurations can be fabricated by EB3DP and then incorporated into various castable matrices (e.g., hydrogels, organic solutions, meltable polymers, etc.). Rapid dissolution of PEC templates within a 2.00 M potassium bromide aqueous solution leads to the high-fidelity7 formation of interconnected channels for free mass exchange. Continuous cell proliferation and ECM deposition is seen as a result. Subcutaneous implantation of channeled silk fibroin (SF) scaffolds with a porosity of 76% could lead to tissue ingrowth as high as 53%. Both histological and immunofluorescence analyses demonstrate that such channeled scaffolds promoted cellularization, vascularization, and host integration along with immunoregulation.

一种骨修复材料的制备方法

Resumen de: CN120884739A

本发明公开了一种骨修复材料的制备方法，属于生物医用材料技术领域。本发明采用Solidworks构建支架模型，利用3D打印技术制备海藻酸钠/壳聚糖/矿化胶原支架，形成具有良好成骨性能的骨修复材料；材料中海藻酸钠、壳聚糖、矿化胶原的质量比：1∶0.2~0.6∶0.2。本发明使用3D打印技术来制备支架，同时选取不同的壳聚糖浓度，以获得一系列不同性能的支架；通过研究发现，当打印墨水中壳聚糖浓度为0.01~0.03g/mL时，海藻酸钠/壳聚糖/矿化胶原打印墨水在酸性交联环境下形成稳定的支架；支架的力学性能随着壳聚糖浓度的增加，呈现上升的趋势；支架的壳聚糖浓度越低且处于pH=7.2‑7.5的环境下胶原释放越快，释放量也越大。

一种制造正畸装置的系统和方法

Resumen de: WO2024199274A1

The present disclosure provides systems and methods for orthodontic appliance production. The methods may include determining a baseline thickness of an orthodontic appliance for orthodontically treating teeth of a target subject. The methods may include, for each local point on the teeth of the target subject, determining a movement path of the local point from an initial location of the local point to a target location of the local point. The methods may also include, for each local point on the teeth of the target subject, determining, based on the movement path and the baseline thickness, a target thickness of the orthodontic appliance corresponding to the local point. The methods may further include directing a three-dimensional (3D) printer to integrally produce, based on the target thickness of the orthodontic appliance at each local point, the orthodontic appliance.

生物基光固化聚氨酯丙烯酸酯树脂及其制备方法和应用

Resumen de: CN120888043A

本发明属于高分子材料技术领域，具体涉及一种生物基光固化聚氨酯丙烯酸酯树脂及其制备方法和应用。本发明的生物基光固化聚氨酯丙烯酸酯树脂的制备方法，包括以下步骤：(1)取催化剂、第一阻聚剂、第一丙烯酸羟基酯和衣康酸混合，在90‑120℃下搅拌反应6‑9h，得到反应产物，然后加入环氧大豆油，在90‑120℃下搅拌3‑5h，得到预聚物；(2)将步骤(1)得到的预聚物降至室温，逐滴加入第二丙烯酸羟基酯和二异氰酸酯，然后在30‑60℃下搅拌反应1.5‑4h，直至NCO红外峰值消失，即得。本发明的树脂生物基含量高，黏度适中，柔韧性好，硬度高，附着力强，光泽度高，气味小，储存稳定性好，适合应用于制备UV固化涂料、UV固化油墨、UV固化胶黏剂、3D打印材料、甲油胶。

IMPLANT

Resumen de: MX2025011378A

This invention relates to an implant (10), including a support arrangement (12) manufactured from a form of a porous material, for receiving and supporting stem cells (14) in a supported condition, for receiving a medium in the form of a neural basal and neural induction medium mixture (20) and the support arrangement (12) being shaped and sized to conform to and be received complementally by an implant zone (16). The implant zone (16) being a space defined by an excised portion of a subject's spinal cord (18). The neural basal and neural induction medium mixture (20) provides nutrients for the development of the stem cells (14) and the growth factors, in form of neurotrophin 3, neurotrophin 4 and brain-derived neurotrophic factor (BDNF) encourage and control development of the stem cells (14), the growth factors typically being constituents of the medium mixture (20).

BIOPRINTING METHODS AND SYSTEMS

Resumen de: MX2025010283A

In a bioprinting system and method, a bioprinter may include one or more reservoirs, a printhead, and a print surface on which the bioprinting is dispensed. An optical system may collect imaging data of a plurality of cells within a cross-linkable material before, during and/or after passage of the plurality of cells through the bioprinting system. A computing system may process the imaging data to determine a quantity, distribution, concentration, and/or morphology of the plurality of cells. A machine learning system compares characteristics of the plurality of cells before, during and/or after passage of the plurality of cells through the bioprinting system to user-established cell morphologies corresponding to physical properties of cells and/or cell aggregates within a predetermined tolerance. Additionally or alternatively, the machine learning system compares characteristics of the plurality of cells at one stage in the bioprinting system to characteristics of the plurality of cells at another stage in the bioprinting system.

FREMGANGSMÅDE TIL FREMSTILLING AF ET FODINDLÆG VED HJÆLP AF 3D-PRINTNING VED HJÆLP AF MÅLINGER AF FODTRYK OG MATERIALETS HÅRDHED OG/ELLER STRUKTUR FOR AT AFLASTE FODTRYKKET

Resumen de: CN114983087A

A method and apparatus for generating a custom manufactured orthotic insole or insole for footwear. Information relating to the pressure exerted by a person's plantar is used to customize the production of orthotic insoles or insoles for a particular person by using softer material or different structural components selectively located at the pressure points to remove the pressure on the foot at these points. A pressure point of a foot of an individual is identified for pressure readings acquired for the foot. The pressure points are quantized and the feet are mapped to the pressure map in a grid format. After the mapping, the structural component corresponding to the particular pressure value is placed in the orthotic insole based on the mapping. The compression unit is made via a 3D printing method based on the individual's pressure readings and the results derived with the electronic pressure plate of the pressure responsive sensor.

TECHNIQUES FOR AUTOMATED MARKING OF DENTAL APPLIANCES

Resumen de: MX2025011659A

The present disclosure discusses techniques for marking a dental appliance. A dental model and dental appliance are positioned onto a conveyor tray, which is transported to a scan station. The dental model and conveyor tray each include an identifying code. The scan station includes a camera and barcode reader to read the identifying codes on the dental model and conveyor tray, and these codes are associated with one another. The conveyor tray then moves to a marking station where a barcode reader reads the code on the conveyor tray, and then marks the dental appliance with the appropriate marking.

Post-processing of biological scaffolds

Nº publicación: IL323431A 01/11/2025

Solicitante:

LUNG BIOTECHNOLOGY PBC [US]
HERNANDEZ GORDILLO VICTOR [US]
KAUR AMAN [US]
NSIAH BARBARA [US]
MORRIS DEREK [US]
ALVAREZ LUIS [US]
LUNG BIOTECHNOLOGY PBC,
HERNANDEZ-GORDILLO Victor,
KAUR Aman,
NSIAH Barbara,
MORRIS Derek,
ALVAREZ Luis

Resumen de: AU2024238878A1

A method of modifying a surface of a three-dimensional (3D) article includes immersing at least one part of the 3D article in a buffered solution of functionalized peptides, allowing reaction between the functionalized peptides and reactive groups on the surface of the 3D article; and washing the at least one part of the 3D article to remove unreacted functionalized peptides. The surface-modified 3D article includes a plurality of peptides covalently bonded to the surface of the 3D article via a cysteine bridge. The surface- modified 3D article can be used as a scaffold for the formation of biological tissue or bodily implants.