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METHOD AND ANALYSIS SYSTEM FOR CREATING A DIGITAL 3D MODEL OF THE DENTITION OF A PATIENT

Resumen de: US20260108329A1

A method for creating a digital 3D model of a patient's dentition, according to the invention, provides that in a computing unit for a plurality of dentition variants, each comprising a combination of a digital 3D model of the upper jaw and a digital 3D model of the lower jaw of the patient, which differ from each other in the relative positioning of the upper and lower jaws, respectively: the digital 3D model of the upper jaw is combined with the digital 3D model of the patient's lower jaw in such a way that the upper and lower jaws rest on each other at a number of contact points without any spatial overlap of parts of the upper and lower jaws, andthe contact surface between the upper and lower jaw is determined, whereby an optimized denture variant is selected as a 3D model of the denture, taking into account the contact surface.

3D PRINTED OR OTHER ANATOMICAL AND CIRCULAR GINGIVAL HEALING CUFFS FOR USE WITH ABUTMENTS

Resumen de: US20260108327A1

An assembly comprising an abutment and gingival healing cuff. The gingival healing cuff fits and mates over the abutment, wherein the cuff includes internal surfaces (e.g., at least one flat face, and at least one curved face) corresponding to the external surfaces of the abutment, so as to mate with one another. The gingival healing cuff can further include a rectangular box or other timing alignment structure positioned apical to a buccal alignment body, which serves as a buccal alignment marker once the buccal alignment body is removed, and which can aid in helping the practitioner know where the implant platform and abutment platform are located (even when hidden). Flowable composite, e.g., of a different color, can be placed into the rectangular box or other timing alignment structure to aid in identification of the buccal surface of the cuff and proper rotational alignment (“timing”) of the abutment with the implant.

COMPOSITIONS AND METHODS FOR BIOPRINTING OF ENERGY-RESPONSIVE BIOINKS

Resumen de: WO2026085159A1

Disclosed are methods and compositions to enable bioprinting of energy-responsive bioinks. The embodiments of the present disclosure relate to ultrasound-controlled gene delivery to a target cell in a three-dimensional bioprinted cell construct. The compositions include, for example, a hydrogel scaffold with a plurality of filament structures printed on a substrate; and a collagen cast gel that encases the hydrogel scaffold; wherein the compositions are configured to receive a population of microparticle-coupled cargo for controlled delivery to one or more target cells by application of ultrasound energy. Also disclosed are methods of creating transgenic target cells using the disclosed compositions.

LATERAL FLOW ASSAY WITH ENCRYPTED DIAGNOSTIC RESULTS

Resumen de: WO2026083139A1

This invention relates to a method of manufacturing a membrane for lateral flow assay or rapid diagnostic assay, a device comprising a membrane for detecting an analyte in a sample and the use of the device for detecting an analyte in a sample, wherein a two-dimensional barcode of a plurality of reagent dots comprising bioreceptors is patterned or printed on the membrane, the plurality of reagent dots being arranged in form of a two-dimensional barcode visible after the completion of the test and in which a certain information associated with the analyte is embedded, and to the use of said device.

METHOD FOR PRODUCING A TEMPLATE FOR A BONE PLATE

Resumen de: WO2026080955A1

The invention relates to a method for producing a template for a bone plate for treating a fracture of a bone of a human or animal, in particular for a bone plate for treating a pelvic fracture of a human. According to the invention, in order to produce the template in a patient-specific manner with high practical applicability, a digital data set of an image of bone fragments of the fracture is obtained using an imaging method, in particular an MRI or CT or X-ray method, wherein the method comprises the following steps: a) creating a digital, in particular virtual, three-dimensional bone model of the bone fracture fragments on the basis of the data set; b) determining a digital template design adapted to the bone model; c) producing, in particular 3D printing, the template on the basis of the determined template design. The invention also relates to a data processing device, to a system for producing the template, and to a computer program product.

PREDICTION OF THREE-DIMENSIONAL HUMANOID AVATARS FOR ANTHROPOMETRIC MODELING

Resumen de: WO2026085249A1

A method is described herein comprising generating a predictive shape model using three dimensional representations and feature parameters of a plurality of subjects, wherein the feature parameters include age, weight, height, and percentage body fat, applying the predictive shape model to target feature parameters of a target plurality of subjects to predict three dimensional representations of the target plurality of subjects, wherein the target feature parameters include age, weight, height, and percentage body fat, using the predicted shapes of the target plurality of subjects to measure anthropometric dimensions, and using the anthropometric dimensions to determine at least one clinical state of the target plurality of subject.

IMAGE-BASED TOOTH IDENTIFICATION USING DIGITAL DENTAL MODELS

Resumen de: US20260108326A1

Systems and methods for identifying teeth in a patient image are provided. For example, a computer-implemented method can include, by one or more processors, accessing a 2D image including a depiction of a patient's teeth, where a plurality of the depicted patient's teeth are annotated with tooth identifiers according to a first tooth identification scheme. The computer-implemented method can further include transmitting, to a server computing device, the 2D image, and receiving from the server computing device, a second tooth identification scheme for the patient's teeth in the 2D image. The second tooth identification scheme can be generated by accessing a 3D model of the patient's teeth, projecting the 3D model onto the 2D image, comparing the projection to the 2D image to determine a probability parameter for each of one or more teeth in the 2D image, and determining, based on the probability parameters, the second tooth identification scheme.

METHOD AND SYSTEM FOR INVERSE KINEMATICS WITH NULLSPACE OPTIMIZATION FOR HUMAN INTERFACE DEVICE ORIENTATION CONTROL

Resumen de: WO2026083236A1

A method performed by a surgical robotic system that includes determining, while the surgical robotic system is in a first operational mode in which a surgical tool is configured to be manipulated according to movement of a HID, an orientation of the HID that includes several joints. The system determines that the system has switched from the first operational mode to a second operational mode in which the surgical tool is to remain stationary as the HID moves within 3D space, and responsive user movement of the HID, determines a new orientation of the HID. The system determines, based on the new orientation of the HID, one or more nullspace joint commands that includes nullspace joint motions of one or more joints to realign the HID from the new orientation to the orientation, and provides the nullspace joint commands to the joints to cause to the realignment of the HID.

USE OF A METASTABLE TECHNETIUM-99 RADIONUCLIDE-COMPRISING RADIOIMMUNOCONJUGATE FOR DOSIMETRY

Resumen de: WO2026082910A1

The present invention concerns dosimetry-related uses and methods that rely on a metastable technetium-99 (99mTc) radionuclide-comprising (dosimetric) radioimmunoconjugate (RIC) to evaluate or establish therapeutic doses of yttrium-90 (90Y) radionuclide-comprising (therapeutic) radioimmunoconjugates, both RICs targeting the same molecular target. More specifically, radioimmunoconjugates that comprise a CD66-binding component are used. Another aspect of the invention relates to Single Time Point dosimetry procedures replacing the need for traditionally used Multiple Time Point dosimetry procedures for yttrium-90 (90Y) radionuclide-comprising radioimmunoconjugates.

METHODS AND SYSTEMS FOR DETECTING A SUCTION EVENT ASSOCIATED WITH A HEART PUMP

Resumen de: WO2026085078A2

Methods and apparatus for detecting a suction event associated with operation of a heart pump are provided. In one example, the method includes receiving a motor current signal associated with a motor of the heart pump, receiving a pressure signal associated with the heart pump, determining a pump flow signal based on the pressure signal, detecting, using a computer processor, a suction event, and displaying, when a suction event is detected, an indication of the suction event on a user interface associated with the heart pump. Detecting a suction event may be based, at least in part on a first value of the motor current signal within a first time window being a first threshold amount less than a baseline motor current signal value, and a first value of the pump flow signal within the first time window being a second threshold amount less than a baseline pump flow value.

DIGITAL SPIRAL TRACING AND FREE DRAWING TESTS

Resumen de: US20260108182A1

0000 Systems and methods are directed to screening a subject for motor and cognitive impairment. A method for screening motor and cognitive impairment comprises administering a spiral tracing assessment to a subject, and receiving a response thereto; assessing the subject's performance based on the response; collecting performance parameters based on the subject's performance on the spiral tracing assessment; providing the performance parameters and the response to a pretrained machine learning model; predicting, using the pretrained machine learning model, a likelihood of the patient having a cognitive impairment; determining a motor and cognitive impairment status of the patient based on the prediction; and outputting the motor and cognitive impairment status.

METHOD AND DEVICE FOR INTRAVITREOUS VOLUME CALCULATION

Resumen de: WO2026080954A1

The invention relates to a method for determination of the vitreous volume of an eye, in particular an eye of a mammal, such as a human eye, the method comprising the following steps: - measuring the axial length of the eye; - applying the measured axial length to equation (II): V = (X * AL3 + Y * AL4) wherein: AL is the measured axial length of the eye in millimeters; X has a value of between 0.200 and 0.300; Y has a value of between 0.0050 and 0.0080; V is the vitreous volume V of the eye in mm3; obtaining or outputting the vitreous volume of the eye as the calculation result of equation (II). The invention also relates to a computer-readable medium, a computer program product, a device, and a kit.

IMPLANT PLANNING SOFTWARE

Resumen de: US20260108304A1

A modified digital library and an algorithm able to make six functions for the improvement of most implant planning software used for the design of the custom surgical guide are provided. The prior art implant planning software available on the market, improved by the modified digital library and algorithm presented here, is essential to guide the digital design of both the custom surgical guide and the CAD-CAM cemented prosthesis onto straight or angled prefabricated abutments, through preliminary determination of abutment position with respect to an appropriate system of reference planes in correspondence with digital crown design. Furthermore, in a future perspective, the improved implant planning software presented here could be usefully employed in robot-assisted dental implant surgery.

METHOD, DEVICE, AND COMPUTER PROGRAM FOR PREDICTING PROGNOSIS OF INTRAVITREAL INJECTION THERAPY

Resumen de: US20260108215A1

0000 The present invention relates to a method for predicting the prognosis of intravitreal injection treatment, comprising the steps of: receiving OCT images and clinical information of a plurality of diabetic macular edema patients; extracting one or more major lesion information from the OCT images; training a multi-modal deep learning model by inputting the OCT images, the clinical information, and the one or more major lesion features, and outputting the intravitreal injection treatment prognosis of the diabetic macular edema patients; and predicting the prognosis of intravitreal injection treatment by inputting the OCT images, the clinical information, and the major lesion features of a specific diabetic macular edema patient to the trained multi-modal deep learning model.

INFUSION VOLUME DETECTION SYSTEM AND METHOD

Resumen de: US20260108673A1

A vision-enabled fluid flow rate detection system is disclosed. The system includes an image sensing device that images an infusion container supplying a fluid to an infusion pump and a pattern of markings associated with a surface of the container, and identifies a visual difference in the pattern from a default state of the pattern to determine a volume of fluid infused from the infusion container, and used to calculate a volume of fluid in the container and a flow rate of the fluid. When the amount of fluid, as determined by the vision system, differs from the amount reported by the pump, the pump's motor may be adjusted to correct the expected volume or flow rate, as needed. When a severe infusion inaccuracy is detected, an alarm or other indication may be provided, or the infusion terminated.

EXTENDED REALITY-BASED BRAIN DISORDER ASSESSMENT SYSTEMS AND METHODS

Resumen de: WO2026085490A1

An extended reality (XR)-based platform integrated with real-time eye-tracking technology that assesses brain functions by leveraging artificial intelligence (AI) models is provided. In a first aspect, a method includes: receiving sensor data from an extended reality (XR) apparatus, and generating, using an artificial intelligence (AI) model, a functional map of a brain of a subject based on the sensor data. The sensor data includes eye-tracking data and is collected by the XR apparatus while the subject performed one or more tasks presented to the subject in a virtual environment by the XR apparatus. The one or more tasks stimulate a plurality of neurotransmitters of the subject. The functional map indicates neurological function of a plurality of regions of the brain. Other aspects and features are also claimed and described.

SELF-SERVICE BOOTH FOR MEDICAL SERVICES AND TELEMEDICINE

Resumen de: WO2026081028A1

The invention relates to a self-service booth for medical care and telemedicine, which helps solve current public health issues such as hospital overcrowding, social inequality between urban and rural areas, long waiting times, lack of medical coverage, lack of technology in certain rural medical centres with basic hospitals, and other problems, wherein the booth has a general cube shape supported on rectangular metal feet, with a height of 2.20 m and a width and depth of 1.80 m. A glazed metal access door is located on the front face, oriented towards the left lateral face, and a removable metal access ramp made of 8 mm thick high-strength steel plates is located below the door. The booth is assembled using a metal structure (of the Metalcon type) and the corners of the booth are protected using a 50 mm L-shaped PVC siding profile. The booth structure is formed by rectangular fibre-reinforced polymer (FRP) panels arranged landscape to form the left lateral, right lateral and rear faces, the floor and the roof, the panels being supported at the upper and lower ends thereof (figure 1).

Advanced Respiratory Monitor and System

Resumen de: US20260108172A1

0000 Disclosed is a bioimpedance measurement system: A stabilized high frequency current generator is connected to padset electrodes via a patient cable. Electrodes are connected to an adaptive circuit that conditions the resulting voltage signal and converts it to digital form. Firmware performs signal acquisition and relays data to the device.

ELECTRONIC DEVICE FOR PROVIDING RECOMMENDATION MESSAGE FOR SKIN CARE, OPERATION METHOD THEREOF, AND NON-TRANSITORY COMPUTER-READABLE STORAGE MEDIUM

Resumen de: WO2026084289A1

An electronic device according to the present disclosure comprises: a communication interface; a memory, which stores instructions and includes one or more storage media; and at least one processor including processing circuitry, wherein, when executed individually or collectively by the at least one processor, the instructions instruct the electronic device to: receive advanced glycation end products (AGEs) data of a user from a wearable device; acquire weather data on the basis of position information of the user wearing the wearable device; input the AGEs data and the weather data into an artificial intelligence model; and allow the artificial intelligence model to provide a recommendation message generated, the artificial intelligence model being trained to: acquire state information of the user on the basis of the AGEs data, and generate the recommendation message for guiding a behavior of the user on the basis of an ultraviolet index and an air quality index included in the weather data and the state information.

METHOD, APPARATUS, AND COMPUTER PROGRAMS FOR SLEEP ENHANCEMENT AND DIAGNOSTICS USING ELECTROENCEPHALOGRAM MONITORING

Resumen de: WO2026085269A1

A method includes identifying electroencephalogram (EEG) sensor data obtained by a wearable device associated with a user's head and providing the EEG sensor data as a first data input to a first trained machine learning model. A first output associated with sleep quality data associated with the user is obtained from the first trained machine learning model. A second input including the sleep quality data and user input data is provided to a second trained machine learning model. A second output associated with sleep therapy data is obtained from the second trained machine learning model. Subsequent to obtaining the second output, subsequent EEG sensor data and/or subsequent user input data is identified, and the first and/or second trained machine learning model is re-trained to generate updated sleep therapy data based on the subsequent EEG sensor data and/or subsequent user input data meeting a first threshold value.

PHOTOPOLYMERISABLE NATURAL OIL-BASED COMPOSITIONS FOR 4D PRINTING OF MULTIFUNCTIONAL BIOMATERIALS

Resumen de: WO2026083418A1

The present invention provides a photopolymerisable composition for 4D printing, comprising an acrylated polyol (AOPO) derived from a natural oil, such as olive oil, and acrylic acid as a comonomer. The composition is used in a solvent-free digital light processing (DLR) method to fabricate high-resolution, multifunctional objects. The resulting 4D printed objects are biocompatible, hemocompatible, and cytocompatible. They exhibit excellent temperature- responsive shape memory properties activated near body temperature, inherent antimicrobial activity against both gram-negative and gram-positive bacteria, and tuneable mechanical properties suitable for soft tissue engineering. Furthermore, the composition can be loaded with therapeutic agents, such as progesterone, to form biodegradable objects capable of sustained, controlled drug release. These properties make the material ideal for medical implants, cardiovascular stents, and drug delivery devices.

FIXED DENTAL APPLIANCE FOR CONTROLLED DRUG DELIVERY

Resumen de: US20260108339A1

0000 A drug delivery device may include a component with a bonding location to be bonded to a surface of one or more teeth. A cavity may hold a formulation that includes a compound, and an orifice may release the compound outside the component.

METHOD AND PROCESS FOR MAKING TATTOO STENCIL INK

Resumen de: WO2026085208A1

An ink composition for a tattoo stencil and methods of making the same are disclosed herein. The ink composition comprises a plurality of cationic violet dyes in combination with a humectant, optionally along with surfactants and/or alcohol. It exhibits enhanced color vibrancy and color reproduction of the transferred tattoo design. The disclosed ink composition also exhibits excellent stability under thermal conditions and is suitable for long-term storage.

PHOTO-CROSSLINKABLE AND 3D PRINTABLE AMPHIBIAN COLLAGEN DERIVATIVES

Resumen de: WO2024258349A1

Disclosed herein is a hydrogel precursor formulation that comprises one or both of a methacrylated bullfrog collagen (ColMA) and a methacrylated gelatin (GelMA), where the gelatin is obtained from bullfrog collagen, and a photoinitiator Also disclosed herein is a bioink comprising the aforementioned hydrogel precursor formulation. Further disclosed herein is a kit of parts comprising a ColMA, a GelMA, and a photoinitiator.

IMPLANT COMPRISING BIODEGRADABLE POLYMER, MANUFACTURING METHOD THEREFOR, AND COMPOSITION THEREFOR

Nº publicación: EP4729079A1 22/04/2026

Solicitante:

CJ CHEILJEDANG CORP [KR]

Resumen de: EP4729079A1

Provided is an implant comprising a first biodegradable polymer and a second biodegradable polymer, wherein the first biodegradable polymer comprises copolymerized polyhydroxyalkanoate (PHA), and the copolymerized PHA comprises, on the basis of the total weight of the copolymerized PHA, 0.1-50 wt% of a repeating unit derived from 4-hydroxybutyrate (4-HB).