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3D PRINTING COMPOSITION FOR BIOMATERIALS

Resumen de: EP4644125A2

A 3D printing resin composition for a biomaterial and method for 3D printing the composition, wherein the composition comprises:(i) a pre-polymer comprising a polymeric unit of the general formula (-A-B-)_n, wherein A represents a substituted or un-substituted ester, B represents a substituted or un-substituted acid ester comprising at least two acid ester functionalities, and n represents an integer greater than 1,(ii) at least one photo-initiator, and(iii) at least one light blocker.

巯基化的重组细菌胶原样蛋白

Resumen de: WO2024188850A1

Recombinant bacterial collagen-like protein, preferably with an amino acid sequence that is at least ≥ 60% identical to the amino acid sequence of SEQ ID NO:1 wherein the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO:1, wherein the recombinant collagen-like protein is functionalized with at least one thiol group. A bioink comprising the functionalized recombinant bacterial collagen-like protein, at least one solvent and optionally at least one photoinitiator, a process for producing a hydrogel by crosslinking the functionalized recombinant bacterial protein or the bioink as well as the hydrogel obtained therefrom. Furthermore, a scaffold for tissue engineering comprising the hydrogel.

一种自产氧生物3D打印间充质干细胞肝脏类器官支架的构建方法

Resumen de: CN120899998A

本发明公开了一种自产氧生物3D打印间充质干细胞肝脏类器官支架的构建方法，其包括以下步骤：制备CaO2@ZIF‑8@SL纳米颗粒；将CaO2@ZIF‑8@SL纳米颗粒加入甲基丙烯酰化明胶和甲基丙烯酰化透明质酸的混合溶液中，以获得所述自产氧生物3D打印间充质干细胞肝脏类器官支架。本发明的方法制得的自产氧生物3D打印间充质干细胞肝脏类器官支架具有在较长时间内释放氧气的稳定性，以及良好的ROS清除能力，且无细胞毒性，可用于构建人肝脏类器官模型。

一种用于治疗心肌梗死的3D生物打印心外膜贴片及其制备方法和应用

Resumen de: CN120900005A

本发明公开了一种用于治疗心肌梗死的3D生物打印心外膜贴片及其制备方法和应用。所述的3D生物打印心外膜贴片是由含有负载重组人血管内皮生长因子(rhVEGF165)的壳聚糖纳米颗粒以及人骨髓间充质干细胞(hMSCs)的甲基丙烯酰明胶(GelMA)生物墨水通过3D生物打印出的具有特定结构的心外膜贴片。通过对所制备的贴片进行形态观察、力学性能检测、溶胀性能检测及降解性能检测，验证了其良好的物理化学特性。体外释放试验表明，该贴片可以持续稳定地释放rhVEGF165，促进细胞增殖和血管生成。体内实验证实其能够有效促进心脏功能恢复，改善心肌重构，并显著增加缺血区域的血管新生。本发明的提出为心肌梗死后的修复提供了新的技术手段。此方法不仅展示了优异的临床转化潜力，也为心血管疾病治疗开辟了新路径。

一种3D生物打印骨髓间充质干细胞血管外支架及其制备方法和应用

Resumen de: CN120900008A

本发明公开了一种3D生物打印骨髓间充质干细胞血管外支架及其制备方法和应用。所述的3D生物打印骨髓间充质干细胞血管外支架是由含有SIRT3过表达的骨髓间充质干细胞(BMSCs)的生物墨水通过3D生物打印获得的，所述的生物墨水中含有甲基丙烯酰化透明质酸(HAMA)以及甲基丙烯酰化明胶(GelMA)。通过建立大鼠动‑静脉移植模型评估其对提高静脉桥远期通畅率的作用。实验结果表明，所述的3D生物打印骨髓间充质干细胞血管外支架不仅具有良好的结构稳定性和生物相容性，还能显著提高静脉桥远期通畅率，促进受损组织修复，增强血管功能恢复能力，在改善心血管疾病治疗效果方面具有潜在的应用前景。

由Ti/Nb/Ta合金粉末生产物体的方法

Resumen de: AU2024242662A1

The present invention relates to a method for producing a body from a Ti/Nb/Ta alloyed powder, a body produced according to this method, and the use of a Ti/Nb/Ta alloyed powder for producing a body by laser powder bed fusion.

利用插入路径的牙齿矫正装置的制造方法

Resumen de: WO2024228520A1

The present invention relates to a program for designing an orthodontic device, and comprises the steps of: (S01) displaying, on a screen, an insertion path for determining the insertion direction of the orthodontic device; (S02) designating a tooth to be set as an insertion path; (S03) setting the insertion path in an arbitrary direction with respect to the designated tooth; (S04) displaying, on a screen, undercuts of each tooth generated by the set insertion path; (S05) calculating and storing depth values of the undercuts for each tooth according to the insertion path; and (S06) calculating and storing the total value of the volume of the undercuts for each tooth according to the insertion path.

一种手术膜及制备工艺

Resumen de: CN120902327A

本发明涉及医疗用品制备技术领域，尤其涉及一种手术膜及制备工艺，在具体使用时，首先通过选用聚氨酯基膜并进行等离子处理；在处理后的聚氨酯基膜表面喷涂含光引发剂的纳米SiO2分散液，随后采用紫外图案化照射，形成微凸起结构得到基材层；将胶体液通过数字微镜装置投射温度梯度掩模，使胶体液在基材层上发生区域性热聚合，形成具有粘性梯度的智能胶层；采用气溶胶喷射打印技术，将超吸水纤维与聚乙烯醇‑硼砂动态交联水凝胶共沉积，形成引流层即可，以此方式解决了现有技术中的手术膜制备方式所制备的手术膜粘附不灵活、表面结构性能差、且制备工艺难精确控制的技术问题。

一种3D打印的清洗固化消毒一体机

Resumen de: CN223520234U

本实用新型公开了一种3D打印的清洗固化消毒一体机，其包括底座，其特征在于：还包括罩设于底座上的外壳、置于外壳内且位于底座上的呈透明的清洗容器、置于外壳内的照射装置，所述照射装置包括至少一组位于清洗容器上开口上方和至少一组位于清洗容器侧边的照射组件，所述照射组件包括紫外灯珠；所述外壳内设置有扰动装置，所述扰动装置包括磁力电机、连接于磁力电机输出轴的磁性片、置于清洗容器内的磁珠，所述磁珠与磁性片磁性相吸。本申请具有对3D打印模型进行更好的清洗、固化和消毒的效果。

一种皮肤的挤出/喷墨复合打印装置

Resumen de: CN223520223U

本实用新型公开了一种皮肤的挤出/喷墨复合打印装置，属于生物组织打印技术领域，包括计算机、三维运动系统、墨盒、喷墨打印头、挤出打印头、温控基板、气泵和压力控制器；墨盒安装在所述喷墨打印头上，喷墨打印头和挤出打印头安装在所述三维运动系统上；压力控制器安装在所述气泵上；压力控制器与墨盒和挤出打印头气连接；计算机分别与所述三维运动系统、喷墨打印头和压力控制器电连接；计算机用于控制所述三维运动系统运动，还用于控制喷墨打印头的喷墨和压力控制器输出气压值。本实用新型提供了一种制造成本低、效率高的个性化皮肤打印装置。

打印装置和蒸汽灭菌器

Resumen de: CN223520491U

本实用新型涉及带有打印机的蒸汽灭菌设备领域，具体为一种打印装置和蒸汽灭菌器，打印装置包括壳体、打印机和盖板。其中，壳体一侧具有开口部；打印机安装于壳体内部，打印机朝向开口部一侧设有打印口，打印口供打印机中的纸卷展开并经其伸出；盖板表面设有腰型孔，盖板以腰型孔对应于打印口的方式，可开启地覆盖于开口部，盖板的设置腰型孔的部位与打印口贴合。通过将腰型孔和打印口贴合设置，可避免打印纸进入打印机与盖板之间的间隙，进而减少工作人员使用蒸汽灭菌器的打印机之前的准备步骤，提高打印机的工作效率，并节约了打印纸的用量。

INTEGRATED VISUALIZATION, SUCTION, AND IRRIGATION SYSTEM FOR ENT PROCEDURES

Resumen de: US2025339015A1

A method of forming an endoscopic device includes forming, by a three-dimensional (3D) printer, a first tube of an endoscopic sleeve, where the first tube is sized to receive an imaging device. The method also includes forming, by the 3D printer, a second tube of the endoscopic sleeve such that at least a portion of the second tube is mounted to the first tube, where the second tube is sized to connect to an irrigation system. The method further includes forming, by the 3D printer, a third tube of the endoscopic sleeve such that at least a portion of the third tube is mounted to one or more of the first tube and the second tube, where the third tube is sized to connect to a vacuum system.

POROUS-BASED TALUS RECONSTRUCTION PROSTHESIS AND ASSOCIATED METHOD

Resumen de: US2025339282A1

This invention is designed for orthopedic applications. It features a proximal surface for tibial articulation, a distal surface for calcaneal engagement, and a central canal for a fixation nail. Offered in spherical, ellipsoidal, and anatomically contoured shapes, the prosthesis includes a gyroid lattice structure for improved osseointegration. A method for its creation involves 3D modeling from CT scans, shape design, lattice definition, and 3D printing, focusing on dimensions and density variations to ensure proper fit and functionality while addressing anatomical needs.

ANTIBACTERIAL DENTAL PHOTOCURING 3D PRINTING RESIN COMPOSITION, 3D PRINTING ARTICLE OF MANUFACTURE, AND USE THEREOF

Resumen de: WO2025227560A1

Disclosed are an antibacterial dental photocuring 3D printing resin composition, a 3D printing article of manufacture, and use thereof. The antibacterial dental photocuring 3D printing resin composition comprises a modified polyurethane acrylate oligomer, a modified epoxy acrylate oligomer, and PLA microspheres. The modified polyurethane acrylate oligomer comprises an antibacterial group introduced into the original polyurethane resin, enabling chemical grafting instead of physical mixing. In addition, the modified epoxy acrylate oligomer comprises an introduced PLA group, further improving the strength and wear resistance of dental resin and ensuring environmental friendliness and safety. The modified oligomers and the PLA microspheres added to the composition work synergistically to enable the composition to have excellent, stable, and lasting antibacterial performance.

3D PRINTER SLURRY COMPOSITION USING SI3N4

Resumen de: WO2025230026A1

Disclosed is a 3D printer slurry composition using Si3N4, which is based on the non-oxide ceramic material of Si3N4, is biocompatible, has excellent bacterial resistance, and has improved flexural strength, fracture toughness and the like. The disclosed 3D printer slurry composition using Si3N4 comprises 60 to 66 wt% of ceramic powder, 30 to 36 wt% of a photocurable binder, and 3 to 5 wt% of a dispersant, wherein the ceramic powder can comprise Si3N4 and a sintering additive.

MAGNETIC CUP ASSEMBLY

Resumen de: WO2025230757A1

A magnetic cup includes a first cup portion including a first magnet and a second cup portion including a second magnet. A target capsule is placed between the first cup portion and the second cup portion. The target capsule is sealed with a first seal. The magnetic cup provides a second seal formed from a magnetic force between the first magnet and the second magnet. Further provided is a tool designed to assist a user for opening the magnetic cup. The tool includes a first arm including a third magnet designed to attract the first magnet through a second magnetic force greater than the first magnetic force, and a second arm including a fourth magnet designed to attract the second magnet through a third magnetic force greater than the first magnetic force.

PLATFORM AND METHOD FOR THE MANAGEMENT AND MANUFACTURE OF RETAINERS

Resumen de: WO2025231428A1

A digital platform for managing and manufacturing retainers is disclosed. The digital platform may be accessed by an orthodontist and a patient and may be communicatively coupled with a manufacturer system. The digital platform may create a patient profile associated with a patient, and the patient profile may include a scan of the patient's teeth. The digital platform may provide the scan of the patient's teeth to the manufacturer system so that the manufacturer system can create the retainer and send it to the patient.

METHOD FOR PRODUCING A DENTAL OBJECT AND DENTAL OBJECT

Resumen de: US2024164878A1

A method of producing a dental object (100), including the steps of producing a pillared support structure (101) on the dental object (100); and producing a lattice structure (103) for reinforcing the support structure (101).

(METH)ACRYLAMIDE-BASED URETHANE OLIGOMER AND ACTIVE-ENERGY-RAY-CURABLE RESIN COMPOSITION CONTAINING SAME

Resumen de: US2018244831A1

An object is to provide a (meth)acrylamide based urethane oligomer which has excellent compatibility with organic solvents and general purpose acrylic monomers and oligomers, a high curing property with an active energy ray, and a low curing shrinkage property, and to provide an active energy ray curable resin composition containing the same which has an excellent adhesion property, moisture resistance, surface curing property, and also a low curing shrinkage property, and a molded article of the same. By using a (meth)acrylamide based urethane oligomer characterized by having a (meth)acrylamide group at the end or in side chain thereof and a cure shrinkage rate of 5% or less, it is possible to prepare a urethane oligomer having high curing property and excellent compatibility with organic solvents and general purpose acrylic monomers and oligomers, and an active energy ray curable resin composition containing the same and having excellent adhesion property can be prepared.

ORTHODONTIC APPLIANCES AND METHODS OF MANUFACTURING

Resumen de: WO2025229219A1

Orthodontic appliances are disclosed, comprising an integrally formed shell including a first shell part comprising one or more first cavities adapted to receive the first teeth of the patient, a second shell part comprising one or more second cavities adapted to receive the second teeth of the patient, and a modified active shell part connecting the first shell part and the second shell part, and wherein the modified active shell part comprises one or more active elements configured to apply forces to the first and/or the second shell part. The disclosure further relates to methods for manufacturing an orthodontic appliance, to computer-implemented methods for generating an input file for a 3D printer and to kits comprising series of consecutive shells.

CONTINUOUS SYNTHESIS OF OCTACALCIUM PHOSPHATE

Resumen de: WO2025229626A1

The present innovation relates to biomaterials, particularly, to the synthesis method of octacalcium phosphate. The method can be applied in the commercial manufacturing of biomaterials for bone tissue regeneration or dental restoration, such as bioinks for 3D printing, calcium phosphate cements, bioceramics, composites and drug delivery systems. The current invention developed a rapid, instant, controllable as well as reproducible procedure for the continuous synthesis of octacalcium phosphate.

A DEVICE FOR MODULATING GROWTH PLATE ACTIVITY AND/OR FOR ORTHODONTIC APPLICATIONS

Resumen de: WO2025229167A1

A device for modulating growth plate activity and/or for orthodontic applications, the device comprising: a first wire-like element (1) a first, preferably plate-like, fixation element (3), configured to be fixated on a bone or a tooth; wherein the first fixation element (3) comprises at least one receiving element (5), wherein the receiving element (5) is configured for receiving a fastening means, each receiving element preferably in the form of a through-hole in the fixation element (3), wherein the first fixation element (3) comprises a first guiding element (7), configured for guiding the first wire-like element (1), and wherein the first fixation element (3) comprises a first deflecting element (11) configured to deflect a portion of the first wire-like element (1); and wherein a first portion, preferably its first end-portion (14), of the first wire-like element (1) is configured to be fixated on a bone or a tooth; or wherein the first portion, preferably its first end-portion (14), of the first wire-like element (1) is fixated on a second fixation element (4), wherein the second fixation element (4) comprises at least one receiving element (6) configured for receiving a fastening means.

POLYMER-PHOSPHATE-BASED COMPOSITION FOR 3D PRINTED IMPLANTS

Resumen de: WO2025228468A1

The invention provides a composition for low-temperature 3D printing of tissue implants, which contains: - calcium phosphate powder, - chitosan particles, - aqueous solution of block copolymer (D,L-polylactide-co-polyglycolide)-b-poly(ethyleneglycol)-b- (D,L-polylactide-co-polyglycolide) (PLGA-PEG-PLGA). A kit and a method for preparing the composition are provided, as well as a method for printing tissue implants using the kit.

Therapeutic Oral Device

Resumen de: US2025339308A1

The present disclosure provides generally for a therapeutic oral device for assessing one or more health aspects of a user and/or alleviating one or more health conditions of a user, and associated methods for using the device. The device may comprise a hard palate portion, a mouth guard portion, and a tongue retainer portion. The hard palate portion may comprise one or more materials. The hard palate portion may also comprise a composite of materials. The mouth guard portion may comprise one or more components that provide stability and maintain the position of the therapeutic oral device within the mouth of a user. The tongue retainer portion may comprise an airway and a predetermined length. In some embodiments, the therapeutic oral appliance may comprise a mandibular mouth guard portion.

微小空隙空間を有するポリマー構造並びにそれを作製するためのシステム及び方法

Nº publicación: JP2025536315A 05/11/2025

Solicitante:

ザボードオブトラスティーズオブザレランドスタンフォードジュニアユニバーシティー

Resumen de: CN120225338A

Aspects of the present disclosure include methods for making polymer structures having microvoid spaces. A method according to certain embodiments includes irradiating a polymerizable composition positioned between a build lift table and a build surface to produce such polymerizable composition, the polymerizable composition has: a polymerized region of the polymerizable composition having a microvoid space in contact with a build lift table and a non-polymerized region of the polymerizable composition in contact with a build surface; removing the build lift from the build surface; contacting the generated microvoid space with a non-reactive composition; and repeating in a manner sufficient to create a polymer structure having a clearly discernible microvoid space. Systems for preparing polymer structures according to the subject methods are also described. Also provided are polymer structures having clearly discernible microvoid spaces, such as where the microvoid spaces are filled with a non-polymerizable composition.