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THREE-DIMENSIONAL SYNTHETIC LYMPHOID ORGANS AND ORGANOIDS FOR ANTIBODY DESIGN AND TESTING

Resumen de: US2025164465A1

Provided herein are methods and systems for bio-printing of three-dimensional organs and organoids. Also provided herein are bio-printed/extruded three-dimensional lymphoid organoids for use in the generation and/or the assessment of immunological products and/or immune responses. Also provided herein are methods and system for lymphoid organoids for use in antigen and epitope discovery, characterizing immune response, and therapeutic compounds testing.

CYBER-PHYSICAL WATERMARKING WITH INKJET EDIBLE BIOPRINTING

Resumen de: US2025166110A1

A method of ascertaining identity, verification, or authentication of a product is disclosed which includes embedding a predetermined watermark on a host image, thereby generating an edible watermarked image, printing the watermarked image using edible ink on an attack-resistant edible substrate, affixing the printed substrate onto the product, providing a color reference chart along with the watermarked image, obtaining an image of the watermarked image from the product, establishing correspondence between the watermarked image and the color reference chart, correcting the obtained image based on the established correspondence, extracting the embedded predetermined watermark from the corrected watermarked image, and determining identity, verification, and authentication of the product by analyzing the extracted predetermined watermark of the watermarked image.

ADDITIVE MANUFACTURING DEVICES AND METHODS

Resumen de: US2025162253A1

In the embodiments of the present disclosure, additive manufacturing devices and methods are provided. The additive manufacturing device includes a light source, a building device, and a light scattering member. The light source is configured to provide light to cure photocurable resins. The building device includes a resin tank configured to store the photocurable resins. The building device has a building surface on which the photocurable resins are cured. The light scattering member is arranged between the light source and the building surface.

LIVING BIOREACTOR COMPOSITIONS AND METHODS OF USE

Resumen de: WO2025106439A1

The present disclosure provides compositions comprising a structure for use as a therapeutic cell niche. Additionally, provided herein are methods for using such compositions, e.g., for use in cell therapy in a subject in need thereof.

CLEAR ORTHODONTIC ALIGNER

Resumen de: WO2024013670A1

The present invention relates to a clear orthodontic aligner comprising at least one molecule capable of changing color or color intensity (CCM). Furthermore, the invention relates to a process for obtaining a clear orthodontic aligner by means of three-dimensional (3D) printing.

PATIENT INTERFACE AND CUSHION THEREOF

Resumen de: WO2024011290A1

A patient interface comprising a plenum chamber, a seal-forming structure constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways, and a vent to allow a continuous flow of gases exhaled by the patient from an interior of the plenum chamber to ambient. The seal-forming structure may comprise a cushion, the cushion being deformable and resilient and at least partially formed by a lattice structure.

PROCESS FOR MANUFACTURING A DENTAL IMPLANT, DEVICE FOR ANODISATION OF A DENTAL IMPLANT, AND DEVICE FOR ACID ETCHING AND COATING OF A DENTAL IMPLANT

Resumen de: EP4555972A1

The present invention describes a 3D printed dental implant manufacturing process in which a chemical treatment process is carried out, preferably acid etching, on the external surface of said implant; and an anodizing process on the inner surface of the cavity of said implant.Furthermore, the present invention refers to a device for aligning an implant body for the CNC machining process through a clamp holder shaft; an implant cavity anodizing device; and a device for etching the outer surface of an implant configured to be implemented in an implant manufacturing process, wherein the implant manufacturing process can be automated and performed on multiple implants simultaneously.

FIBROCARTILAGE-DERIVED BIOINK COMPOSITION, BONE GRAFT COMPOSITION CONTAINING SAME, AND MANUFACTURING METHOD THEREFOR

Resumen de: EP4556032A1

The present invention relates to a fibrocartilage-derived bioink composition, a bone graft composition containing same, and a manufacturing method therefor. More specifically, it is identified in the present disclosure that the inner, mid, and outer compartments of the meniscal cartilage tissue based on anatomical location differ from each other in terms of physicochemical property, whereby use is made of the extracellular matrix derived from each compartmentalized tissue to provide 3D-printing bioink compositions and bone grafts, each having distinct physicochemical properties, which can be utilized with controlled physicochemical properties according to desired applications.

3-D BIOPRINTING COMPRISING BIOLOGICALLY-RELEVANT MATERIALS AND RELATED METHODS

Resumen de: WO2024015237A1

The present disclosure provides a method of bioprinting a 3-D structure comprising one or more biologically-relevant materials on a super-hydrophobic surface. In one embodiment, the method comprises providing a composition having one or more biologically-relevant materials dispersed within a biocompatible medium. A pattern comprising a hydrophilic material is deposited on a defined area of the super-hydrophobic surface, wherein the pattern is modeled after a biological structure. The composition having the one or more biologically-relevant materials is then bioprinted atop the hydrophilic surface to form a 3-D structure, wherein the hydrophilic surface maintains the 3-D structure in a desired position or shape on the super-hydrophobic surface.

SURGICAL CLIP APPLIER COMPRISING ADAPTIVE CONTROL IN RESPONSE TO A STRAIN GAUGE CIRCUIT

Resumen de: EP4555969A2

A surgical clip applier comprising an electric motor system is disclosed. The electric motor system is configured to drive a clip firing system of the surgical clip applier. The surgical clip applier further comprises a control system configured to control the electric motor system. The control system is configured to monitor a strain gauge circuit to assess the crimping force experienced by the clip firing system. In at least one instance, one or more strain gauges are mounted to a drive shaft and/or jaw of the clip firing system. The control system modifies the operation of the surgical clip applier when the voltage of the strain gauge circuit exceeds and/or falls below a threshold. In at least one instance, the control system modulates the width, or duration, of voltage pulses applied to the electric motor system to control the speed of the electric motor system.

ラピッドプロトタイピングまたはラピッドマニュファクチャリング法において使用するための光線硬化性組成物

Resumen de: WO2023213699A1

The invention relates to a polymerisable, radiation-curable composition, in particular a UV/Vis-curable, UV-curable or Vis-curable composition comprising (i) monomers and (ii) at least one further component, wherein the (i) monomers comprise (a) at least one urethane (meth)acrylate that is at least difunctional, (b) at least one monofunctional acrylate having an alicyclic group and/or at least one monofunctional methacrylate having an alicyclic group, and (ii) the at least one further component comprises (c) at least one photoinitiator for the UV and/or visible range or a photoinitiator system for the UV and/or visible range. The composition according to the invention is suitable for producing dental prosthetic parts, orthopaedic instruments or dental pre-forms, which are characterised by a) a flexural strength of greater than or equal to 75 MPa, and/or b) a modulus of elasticity of greater than or equal to 2600 MPa, and/or c) a water absorption of less than 45 μg/mm3, wherein these dental prosthetic parts, orthopaedic instruments or dental pre-forms can be produced using a rapid prototyping process or using a rapid manufacturing or rapid tooling process.

一种基于玉米醇溶蛋白的3D生物打印基质材料及其制备方法与应用

Resumen de: CN120000849A

本发明属于天然高分子材料改性及其应用技术领域，公开了一种基于玉米醇溶蛋白的3D生物打印基质材料及其制备方法与应用，具体涉及一种玉米醇溶蛋白与普朗尼克F127接枝物和其制备方法与其在3D生物打印中的应用。本发明材料由端炔基普朗尼克F127与聚多肽修饰的玉米醇溶蛋白反应得到。本发明基于玉米醇溶蛋白和普朗尼克F127提供了一种3D生物打印基质材料，具有优异的生物相容性，利用其制备得到的生物支架材料，可实现细胞优异的粘附增殖；较低的凝胶浓度，解决了F127高浓度的人体危害性；温度敏感特性，使其在室温下为可流动的溶胶状态，而在体温下为凝胶化状态，基于其得到的生物支架材料在体温环境中成型并稳定存在。

一种丝素蛋白生物墨水及其制备方法与应用

Resumen de: CN120000854A

本发明涉及一种丝素蛋白生物墨水及其制备方法与应用，属于生物墨水制备技术领域。本发明通过将再生丝素蛋白水溶液进行浓缩、稀释和孵化，得到具有纳米纤维的丝素蛋白水凝胶；采用机械搅拌机对具有纳米纤维的丝素蛋白水凝胶进行破碎处理10min～100min，获得微粒尺寸为10μm～200μm的丝素蛋白微凝胶；将所得丝素蛋白微凝胶离心去除气泡，得到所述丝素蛋白生物墨水。本发明制备的丝素蛋白生物墨水满足挤出式生物三维打印的要求，具有优异的可打印性和形状保真性，打印结构体轮廓清晰，结构细节还原度高，能够实现多种复杂3D支架结构的高精度打印，为实现目标组织仿生结构的个性化定制提供了可能。

一种基于双光子3D打印的超分子离子液体水凝胶及其应用

Resumen de: CN120005112A

本发明涉及水凝胶技术领域，具体涉及一种基于双光子3D打印的超分子离子液体水凝胶及其应用。超分子离子液体水凝胶由光刻胶通过双光子聚合反应制得，光刻胶包括以下重量份的原料：丙烯酸树脂1‑5份、丙烯酸单体1‑5份、水溶性光引发剂0.1‑2份、亲水性咪唑类离子液体1‑5份和溶剂1‑3份；亲水性咪唑类离子液体为1‑乙基‑3‑甲基咪唑鎓二氰胺盐。本发明基于光聚合诱导的微观相分离策略，解决现有水凝胶双光子吸收效率低、导电性与机械性能失衡的问题，实现微米级复杂结构按需成型，兼具高导电率与良好的机械性能。

微创在体骨组织3D打印修复装置

Resumen de: CN120000384A

本发明提供一种微创在体骨组织3D打印修复装置，其包括：第一球囊导管，其包括第一导管和第一球囊，第一球囊在扩张状态下能够封堵待修复骨组织的长度方向一端的进液；第二球囊导管，其包括第二导管和第二球囊，第二球囊在扩张状态下能够排空待修复骨组织的内部的液体；第三球囊导管，其包括第三导管和第三球囊，第三球囊在扩张状态下能够封堵待修复骨组织的长度方向另一端的进液；和3D打印导管，其能够在由第一球囊和第三球囊分别封堵待修复骨组织的长度方向一端和长度方向另一端的进液、且由第二球囊排空待修复骨组织的内部的液体之后，并且在将第二球囊导管撤出之后，将用于对待修复骨组织进行修复的打印材料挤出至待修复骨组织的内壁上。

光聚合引发剂

Resumen de: TW202432621A

To provide a photopolymerization initiator that has low inhibition of polymerization by oxygen, good photopolymerization initiation properties in air, high sensitivity to long wavelength light, and can suppress the occurrence of odor and bleed-out problems in the resulting cured product. A photopolymerization initiator having one or more benzopheno groups and one or more saturated or unsaturated 5-membered or more cyclic substituent having one or more heteroatoms, and at least one carbon atom of the aryl group of the benzopheno group is connected to the saturated or unsaturated 5-membered or more cyclic substituent having one or more heteroatoms though a carboxylic acid ester group or a carboxylic acid amide group.

一种3D打印的可降解骨缺损填充块

Resumen de: CN120000845A

本发明提供一种3D打印的可降解骨缺损填充块及其制备方法，所述骨缺损填充块以3D打印技术一体成型制得,所述骨缺损填充块的材质为锌合金，按重量百分比计，所述锌合金的组分包括镁0.1‑2％、杂质＜0.2％、锌＞98％、上述各组分重量百分百之和为100％。

用于材料改性的方法和系统

Resumen de: WO2024044071A1

Systems and methods for improving biocompatibility and mechanical properties of cardiac repair and regenerative devices are described. Laser techniques can be applied for material modification of various parts of cardiac repair and regenerative devices including patterning on the frame, leaflets, and/or skirt material. Material modification can aid in healing, tissue acceptance, and/or anchoring of the prosthetic valve.

医用3D打印装置

Resumen de: CN120000383A

本发明提供了一种用于骨组织的在体修复和重建的新型的医用3D打印装置。该医用3D打印装置包括：打印材料供给装置，其供给包含骨粉和骨水泥的打印材料；第一通道管，其构成为前端能够插入至骨组织；第二通道管，其以可移动的方式设置于第一通道管内，并且其前端连接有自膨胀覆膜支架；打印导管，其以可移动的方式设置于第二通道管内，具有与打印材料供给装置连接的输送管和设置于输送管的前端的打印喷头；和穿刺部件，其构成为能够将覆膜支架的覆膜刺破。根据本发明，能够实现手术创伤小，与患者解剖结构匹配度高，且能够排除体内的组织液等的干扰，实现在手术过程中实时、精准的在体打印。

一种生物医用复合材料及其制备方法

Resumen de: CN120006131A

本发明提供一种生物医用复合材料的制备方法，属于生物医用材料技术领域，包括以下步骤：将钽、铌、锆粉末混合均匀后采用3D打印技术制备多孔钽‑铌‑锆骨架；称量金属单质和无机物，将金属单质与无机物置于石墨坩埚中放入加压感应炉内，通入保护性气氛，加热加压感应炉并搅拌，制得孔内填充物；将制备的多孔钽‑铌‑锆骨架全部浸入孔内填充物，继续通入保护性气氛并保温；待加压感应炉冷却后即制得生物医用复合材料。本发明可解决现有合金作为生物医用材料力学性能不适配、生物相容性差的问题。

一种具备消毒功能的医用胶片打印机

Resumen de: CN120003170A

本发明涉及医用器械技术领域，尤其是指一种具备消毒功能的医用胶片打印机，包括胶片打印机主体，胶片打印机主体的前侧开设有操作槽，操作槽内设置有操作屏，操作槽内设置有紫外线灯，胶片打印机主体的顶部固定设置有手卷架，手卷架内设置有绕卷组件，绕卷组件上绕卷有密封帘，密封帘的底端滑动贯穿手卷架并延伸至操作槽内，密封帘前侧的底部固定安装有配重块；本发明在配重块带动密封帘下降时密闭操作槽的过程中，此时气流会通过通孔将减速伞面吹动并鼓起，使得减速伞面因受到气流阻力而向上拉动密封帘，从而实现了对密封帘减少下降的效果，避免配重块将密封帘拉扯损坏和砸坏胶片打印机主体的效果，有助于延长该打印机的使用寿命。

一种智能电子导管及其制备方法

Resumen de: CN120003020A

本发明公开了一种智能电子导管及其制备方法，属于体内医疗传感技术领域。包括以下步骤：制备银/氯化银参比电极、钙离子传感电极、钾离子传感电极、钠离子传感电极、胆红素传感电极、牛磺酸传感电极及过氧化氢传感电极；对静脉导管表面进行亲水处理，附着制备的金属凝胶打印浆料；将金属凝胶打印浆料3D打印在静脉导管表面；裁剪各传感电极和参比电极并黏附至金属凝胶打印线路末端后进行加热以得到金属凝胶打印线路；对金属凝胶打印线路进行封装处理，得到电子导管。相较于现有技术，本发明的有益之处在于，实现在医疗导管表面打印金属凝胶，并设计针对肠外营养各类并发症的化学信号传感器，结合机器学习进行趋势预测。

牙颌模型底托、牙颌模型及牙颌模型套组

Resumen de: CN222870668U

本实用新型公开一种牙颌模型底托，用于承载牙颌模型，牙颌模型底托用于承载牙颌模型的承载面设有若干个凸台结构，凸台结构与设置于牙颌模型底面的凹槽结构凹凸匹配，装配后，凸台结构远离承载面的一端与凹槽结构远离牙颌模型底面的一端抵接，并且承载面与牙颌模型底面具有预设间隙。本实用新型还提供一种牙颌模型，牙颌模型的底面设置有若干个与牙颌模型底托承载面上的凸台结构凹凸匹配凹槽结构。本实用新型还提供一种牙颌模型套组，包括上述的牙颌模型底托和牙颌模型。本实用新型提供的牙颌模型底托、牙颌模型，以及牙颌模型套组，能够解决牙颌模型的底面因打印不平整导致的放置不平稳的问题，有利于提升隐形矫治器切割过程中的切割精度。

一种乳牙牙体预备用引导导板的压印制作装置

Resumen de: CN222870673U

本实用新型公开了一种乳牙牙体预备用引导导板的压印制作装置，包括：压印模型、导板、修剪凸起；压印模型在计算机软件中根据患者牙列模型设计，压印模型通过3D打印技术打印成实体；导板通过压膜膜片在压印模型上压印而成；压印模型上分布有修剪凸起，修剪凸起沿压印模型的牙列轴面环绕形成导板的边缘修剪路径，修剪凸起沿压印模型上患牙的咬合面、轴面环绕形成导板的开窗路径，修剪凸起上设有沿其路径开设的凹槽；本实用新型在制作备牙导板时通过不同结构的修剪凸起进行引导，能够避免裁切工具在操作时易脱离修剪凸起的凸面，而造成导板裁切边缘不平整，以及预备引导窗尺寸开设不精准的问题，以通过使用尺寸精准的备牙导板提高备牙调磨精度。

一种小耳畸形再造术相关肋软骨雕刻训练模型及其制造方法

Nº publicación: CN120014921A 16/05/2025

Solicitante:

四川大学华西医院

Resumen de: CN120014921A

本发明公开了一种小耳畸形再造术相关肋软骨雕刻训练模型及其制造方法。本发明中，通过精确的CT扫描和高级的三维重建技术，结合SLA 3D打印技术，能够直接从数字模型一步到位打印出肋软骨雕刻训练模型。这种一次成型的好处在于，它避免了传统制造方法中可能出现的多步骤组装和接合的复杂性和误差。每个模型都是一体成型的，确保了模型的准确性和结构的完整性。这种方法不仅提高了生产效率，还减少了人为错误的可能性，从而提高了模型的可靠性和训练效果。医生和外科医生可以使用这些模型进行手术模拟和训练，而不必担心模型的不准确或不真实。