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169
resultados
Última actualización
02/02/2026 [07:04:00]
Resumen de: WO2024233888A1
A dose divider for releasable attachment to a plunger rod of a syringe comprises first and second arms. A front portion of the first arm and the front portion of the second arm form a channel therebetween for receiving the plunger rod. A resilient hinge pivotably couples the first arm and the second arm such that the dose divider is reversibly movable between first and second configurations. When the dose divider is in the second configuration, the dose divider is configured to receive the plunger rod in the channel through an opening formed between the front portions of the first and second arms. The channel has a shape configured to receive a specific outer shape of the plunger rod. The front portions of the first and second arms are closer when the dose divider is in the first configuration than when the dose divider is in the second configuration.
Resumen de: WO2025018078A1
A drug packaging device is provided with a feeding mechanism for feeding a long sheet, a sealing device for sealing the long sheet to form a packaging bag in which a drug is accommodated, and an identifier imparting means. The long sheet is provided with a first surface constituting the inner surface of the packaging bag. The identifier imparting means is configured to apply ink onto the first surface of the long sheet to form an identifier for identifying information regarding the drug to be packaged.
Resumen de: CN121427008A
本发明涉及一种3D打印用树脂及其制备方法和用途与光固化性树脂组合物及其固化物。该3D打印用树脂的制备方法包括：(1)使得氨基葡萄糖硫酸盐类化合物与(甲基)丙烯酰卤进行反应，以得到包含氨基葡萄糖(甲基)丙烯酰胺的反应混合物；(2)将所述反应混合物与包含(甲基)丙烯酸甲酯的有机化合物接触，并从所得的接触混合物中提取有机相，(3)将所述有机相与光固化性化合物进行混合，相对于所述3D打印用树脂的总质量100质量％，所述氨基葡萄糖(甲基)丙烯酰胺的含量为3质量％以上且10质量％以下。
Resumen de: CN121422296A
本发明属于骨修复材料技术领域，公开一种跨尺度梯度结构的制备方法、骨修复材料及应用方法。制备时先将半导体生物材料制成生物异质结悬浮液，再与光固化水凝胶混合形成体系；将骨植入体基材与导电材料分别作为正负电极置于体系中，施加电场使生物异质结粒子定向沉积形成梯度，经光固化固定得带跨尺度梯度结构的骨修复材料，可按需预置多孔支架。该方法制得的材料模仿人体骨骼天然梯度结构，兼具导电、抗菌等复合功能，能兼顾力学支撑与生物活性，适配脊椎修复、肿瘤术后骨缺损等场景，解决传统骨修复材料结构不匹配、功能单一的问题，提升骨整合效率与临床安全性。
Resumen de: CN121427135A
本申请提供了一种3D打印相变导热温度监控贴片的制备方法，涉及温度监控贴片技术领域，包括以下组分：石墨烯、羧基化碳纳米管、海藻酸钠、月桂酸和硬脂酸。本发明通过利用石墨烯、羧基化碳纳米管、海藻酸钠、月桂酸和硬脂酸制备多重氢键作用，互锁相变材料，调控配方中的组分和3D打印工艺参数，制备了一种适配3D打印的流变性需求的配方，并且能够让碳材料有合适的取向流，在较低的含量下实现导热和导电，具有高精度的成型控制，有较好的人体舒适性和较高的温度响应性。
Resumen de: CN121422295A
本发明属于生物医用材料与口腔种植技术领域，具体涉及一种具有梯度多孔结构和分区改性表面的钛合金口腔种植体及其制备方法。种植体总体分为上下两区域，下区域采用创新三级梯度多孔结构，颈缘区为小孔，中部过渡区为中孔，根区为大孔；实现种植体嵌入颌骨部位后弹性模量从冠部到根部的逐步降低，与天然牙槽骨力学性能相匹配，有效降低应力屏蔽效应。种植体表面通过飞秒激光技术进行分区改性处理，上区域处理后显著促进小鼠成纤维细胞的粘附和增殖；下区域处理后形成特定的微纳米复合结构，可显著提高成骨细胞的增殖率和碱性磷酸酶活性。本发明通过结构‑功能一体化设计，同时实现力学适配性优化、软组织封闭性增强和骨结合效能提升。
Resumen de: WO2026025109A1
Some embodiments provide methods for forming self-supporting, three-dimensional structure by extrusion of a fiber-hydrogel composite material that is solid prior to extrusion, liquifies under stress during extrusion, and resolidifies after extrusion to form the self-supporting, three-dimensional structure. No support bath, no coagulating bath and no cross-linking bath are used during extrusion of the fiber-hydrogel composite material to form the three-dimensional self-supporting structure. In some embodiments, the self-supporting, three-dimensional structure is a tissue scaffold. In some embodiments, the resulting self-supporting three-dimensional structure is edible.
Resumen de: WO2026022121A1
A method of manufacturing a bioresorbable polymeric intravascular tubular device using a 3D printer and a bioresorbable polymeric intravascular tubular device are provided. The method comprises patterning a linear micropattern design comprising different periodicities ranging from 3 μm to 32 μm and a given depth onto a surface of a steel rod; dispensing, while the steel rod is rotating, a polymer-based ink on the generated linear micropattern using a nozzle of a 3D printer; and obtaining a bioresorbable intravascular device with an inner biomimetic topography through solidification of the polymer-based ink.
Resumen de: WO2026020212A1
The present invention pertains to a method for producing an intraoral device in analogue, semi-digital, and digital systems, by means of a positioning jig for gnatostatic models for making intraoral devices. In the analogue system, the hinge articulator is replaced by the Gnatoforo HT AS in the gnatostatic study and working models, alongside transfer guides of the Camper's Plane (CP) with rods of the positioning jig for intraoral devices, referred to as AS-DIORS. The semi-digital system reduces the number of steps from ten to seven, beginning with a CT scan of the cranium in maximum intercuspation and intraoral scanner, or MPTv. The digital system produces the DIORS in three steps: CT scan of the cranium in maximum intercuspation and intraoral scanner MPTv, processing the 3D images for making gnatostatic models in maximum intercuspation with MPTv, printing of the gnatostatic models, and finally 3D printing of the DIORS.
Resumen de: US20260031238A1
Systems and methods are provided for multi-schema analysis of patient specific anatomical features from medical images. The system may receive medical images of a patient and metadata associated with the medical images indicative of a selected pathology, and automatically classify the medical images using a segmentation algorithm. The system may use an anatomical landmark detection algorithm leveraging Deep Reinforcement Learning (DRL) techniques to automatically locate one or more anatomical landmarks associated with the patient specific anatomical feature within the medical images. A 3D surface mesh model may be generated representing the patient specific anatomical features including the located one or more anatomical landmarks. The located one or more anatomical landmarks may be used to guide placement of a 3D model of a medical device that may be fused with the 3D surface mesh model to generate a patient specific 3D model of the medical device.
Resumen de: US20260028489A1
The present disclosure provides curable compositions comprising polymerization inhibitor-functionalized particles to prevent undesired polymerization of the polymerizable compounds in the curable compositions during their transportation, handling or storage, or during 3D printing processes. Such curable compositions can be used to produce polymeric materials with properties suitable for use in various 3D printed objects, such as orthodontic appliances.
Resumen de: US20260028440A1
The invention relates to a curable composition comprising a (meth)acrylate not comprising an urethane moiety, an urethane (meth)acrylate, photo-initiator, discrete filler particles having an average particle size in the range of 10 to 40 nm, having been surface treated with a silane surface treating agent selected from a silane surface treating agent comprising a (meth)acrylate moiety, a silane surface treating agent not comprising a (meth)acrylate moiety, and a mixture of both, and the discrete filler particles being present in an amount of 20 wt. % or more, the curable composition further comprising additives, the curable composition not comprising the following components alone or in combination: aggregates of nano-sized particles, agglomerates of nano-sized particles, fumed silica, each in an amount of 2 wt. % or more, wt. % with respect to the curable composition.
Resumen de: US20260027773A1
A system includes a build platform configured to support an object that is being formed from layers of resin. The system further includes one or more blades configured to provide the layers of resin to form the object on the build platform. At least a first blade of the one or more blades is configured to vibrate to reduce viscosity of the layers of resin.
Resumen de: US20260027262A1
A method for cell printing is disclosed. The method includes generating a receiver substrate, ablating or removing a portion of the receiver substrate via a first laser to expose a target layer, generating a donor substrate containing a back surface and a front surface, applying a coating of donor material to the front surface. The method further includes aligning the front surface of the donor substrate to be parallel to and facing the receiver substrate, wherein the donor material is disposed adjacent to the target layer, and irradiating the coating through the back surface of the donor substrate with one or more laser pulses produced by a second laser to transfer a portion of the donor material to the target layer. A system for cell printing is also disclosed.
Resumen de: US20260027035A1
An object of the present invention is to provide a photopolymerization initiator that is hardly affected by inhibition by oxygen, has good photoinitiating property in air, has high sensitivity to long-wavelength light, and can suppress odor and bleed-out problems of a cured product to be obtained. A photopolymerization initiator having one or more benzophenone groups and one or more saturated or unsaturated 5 or more-membered cyclic substituents having heteroatoms in a molecule, wherein one or more saturated or unsaturated 5 or more-membered cyclic substituents having heteroatoms are bonded to one or more carbon atoms of an aryl group of one or more benzophenone groups through a carboxylic acid ester group or a carboxylic acid amide group.
Resumen de: US20260026804A1
A surgical stapling assembly is disclosed. The surgical stapling assembly can include a first jaw, a second jaw, an articulation joint, a closure drive comprising a first flexible rotary drive extending through the articulation joint, and a firing drive comprising a second flexible rotary drive extending through the articulation joint and rotatable independent of the first flexible rotary drive. The surgical stapling assembly can further include a 3D-printed component.
Resumen de: US20260026955A1
Methods and systems are disclosed for manufacturing a custom-fit wearable device. In general, the methods and systems include generating a three-dimensional model of a body portion, identifying one or more anatomical landmarks, and mapping a curve onto the model based at least in part on those landmarks to define a continuous surface. Thickness and an offset may be applied to the surface. The resulting model may then be used to control an additive manufacturing process to produce the custom-fit wearable device.
Resumen de: US20260026926A1
An endoscopic printing device comprising: a printing head having: a nozzle for outputting a biomaterial; a central conduit connectable to a source of the biomaterial and connected to the nozzle, the central conduit being flexible; ribs disposed around the central conduit and spaced apart from one, a rib of the ribs defining three or more guiding apertures extending axially through the rib, the ribs being interconnected to one another; and cables extending through the guiding apertures, ends of the cables attached to the central conduit, the cables configured to be engaged to an actuator for controlling motion of the endoscopic printing head; and an actuation system engaged to the cables, the actuation system including actuators each engaged to a respective one of the cables, the actuators operable to vary a tension in one or more of the cables relative to a remainder of the cable to bend the central conduit.
Resumen de: AU2024312714A1
This disclosure is directed to compositions of engineered cells that are incorporated into immunomodulatory substances that act as semi-permeable membranes. These compositions provide for sustained delivery of various biologic and therapeutic molecules, such as cytokines or monoclonal antibodies, for a range of diseases, including infectious diseases, cancer immunotherapy and auto-immune disorders.
Resumen de: WO2026022080A1
The invention relates to a suprastructure (14) for a dental prosthesis (10), comprising: a tooth-crown main body (24) which carries at least one artificial tooth crown; a positioning body (26) having a through-opening for receiving a fastening means (16) for indirectly or directly fastening the suprastructure (14) to a dental implant (12); and a coupling device which captively couples the positioning body (26) to the tooth-crown main body (24) and is designed to allow for a relative movement of the positioning body (26) relative to the tooth-crown main body (24).
Resumen de: WO2026020671A1
A microfluidic 3D-printed hydrogel based on fish liver decellularized extracellular matrix for liver regeneration and a preparation method. The hydrogel is prepared by means of combining fish liver decellularized extracellular matrix (dECM) and gelatin methacryloyl (GelMA), and loading induced pluripotent stem cell-derived hepatocytes (iPSC-heps) for liver regeneration. The microfluidic 3D-printed hydrogel based on fish liver decellularized extracellular matrix exhibits excellent biocompatibility, retains intact endogenous growth factors, maintains the biological activity of cells, ensures the effective encapsulation of the cells, and facilitates the robust functional expression of the iPSC-heps. After in-vivo transplantation, the survival rate and liver function of mice with acute liver failure are significantly improved, and liver regeneration and repair are promoted.
Resumen de: EP4684812A1
The present invention relates to a 3D printing ink composition including a pluronic copolymer, an acrylamide monomer, an alkali metal salt and a solvent, and a 3D printing molded article formed by curing the ink composition.
Resumen de: EP4685229A1
There is a demand for establishing a technique for realizing tissue regeneration even in cases of severe periodontal tissue loss. The present invention provides a periodontal tissue regeneration material for grafting, which contains graft tissue containing mesenchymal stem cells and collagen secreted from the mesenchymal stem cells. The graft tissue each include 2 × 10<sup>5</sup> or more cells, and have a projected area equivalent circle diameter or a thickness of 1 mm or more.
Resumen de: US2024342342A1
The present disclosure generally relates to nerve grafts (e.g., allografts), particularly to methods of preparing immunologically anonymized nerve segments and methods of preparing personalized nerve grafts. The present disclosure also provides methods of regenerating a nerve defect.
Nº publicación: EP4684765A1 28/01/2026
Solicitante:
UNIV CATALUNYA POLITECNICA [ES]
Universitat Polit\u00E8cnica De Catalunya
Resumen de: EP4684765A1
A method of manufacturing a biodegradable polymeric intravascular tubular device using a 3D printer and a biodegradable polymeric intravascular tubular device are provided. The method comprises patterning a linear micropattern design comprising different periodicities ranging from 3 µm to 32 µm and a given depth onto a surface of a steel rod; dispensing, while the steel rod is rotating, a polymer-based ink on the generated linear micropattern using a nozzle of a 3D printer; and obtaining a biodegradable intravascular device with an inner biomimetic topography through solidification of the polymer-based ink.
BOPI
Sede Electrónica
