Bioimpressió 3D

A BIOACTIVE POLY(LACTIC-CO-GLYCOLIC ACID) (PLGA) MATERIAL, RELATED PRINTED STRUCTURE AND RELATED METHODS THEREOF

Resumen de: WO2024181920A1

There is provided a regenerative material for treatment of wounds, the material comprising: (i) a base poly(lactic-co-glycolic acid) (PLGA); (ii) a bioactive poly(lactic-co-glycolic acid) (PLGA) copolymer; and (iii) pores patterned on said material. Also provided are a medical device comprising said regenerative material, medical uses of said regenerative material, and a method of preparing said regenerative material.

NOVEL PROCESS

Resumen de: WO2024201321A1

The present invention relates to a process for obtaining a dental prosthesis comprising a crown and tooth root. Said process comprises at least one step of directing undifferentiated cells or keratinocytes and at least one three-dimensional printing step, preferably 3D bioprinting of the dental prosthesis. Furthermore, the invention regards the dental prosthesis obtained with the process and a bioink suitable for three-dimensional printing (3D), preferably suitable for 3D bioprinting.

ORTHODONTIC APPLIANCE SYSTEMS AND METHODS OF MAKING SAME

Resumen de: WO2024206597A1

An orthodontic appliance system for orthodontic treatment of teeth. The system includes a template with a cavity. An attachment is removably received in the receptacle and has a surface including a bonding surface. A method of manufacturing includes constructing a scaffold assembly including a base and placing a template in contact with the scaffold assembly. The method includes inserting the attachment into the receptacle. During separating, the attachment remains coupled to the template in the receptacle. A method of manufacturing includes providing a mold of the patient's teeth. The mold including at least one projection and a through-passage. The method includes placing a container of dental composite in fluid communication with the through-passage, placing a template over the at least one projection, injecting dental composite from the container through the through-passage and into the receptacle, and removing the template from the at least one projection with the filled receptacle.

CONTROL OF HEATING AND COOLING IN 3D BIOPRINTING

Resumen de: GB2629895A

3D printing assembly 10, suitable for bioprinting, the assembly including an enclosure 100 defining an enclosure internal area 101, a printer 200 enclosed within the internal area, the printer comprising a printer bed 240, the enclosure comprising plural sides 110, one or more of said sides having at least one temperature regulator element 112 in or on the respective side 110, wherein the or each temperature regulator element is arranged to introduce heat energy into, and/or remove heat energy from the internal area 101, and wherein the printer bed has at least one bed temperature regulator element 242 in or on the printer bed further arranged to introduce heat energy into, and/or remove heat energy from the printer bed, the sides formed from spaced apart panels and the temperature regulator element is mounted between the panels. The temperature control may be aided by air flow from a fan 130 or the like. The wall and/or bed temperature regulator element(s) maybe Peltier type devices. Bioink storage 210 maybe provided. Plural temperature sensors (TP1,TP2 and TP3) maybe provided. An enclosure for enclosing a 3D printer and a controller for a 3D printer are also provided.

POSTERIOR BITE INTERFERENCE ELEMENTS

Resumen de: US2025375269A1

The present disclosure discusses techniques for fabricating bite interference elements within polymeric dental appliances. The techniques disclose at least one polymeric shell that includes a number of cavities shaped to fit over a patient's teeth. The polymeric shell includes an occlusal appliance surface shaped to fit over an occlusal tooth surface of the patient. One or more bite interference elements are formed within the occlusal appliance surface, and each bite interference element includes a partially disc-shaped feature extending radially away from the occlusal tooth surface when worn by the patient.

IMPLANT

Resumen de: AU2024241734A1

This invention relates to an implant (10), including a support arrangement (12) manufactured from a form of a porous material, for receiving and supporting stem cells (14) in a supported condition, for receiving a medium in the form of a neural basal and neural induction medium mixture (20) and the support arrangement (12) being shaped and sized to conform to and be received complementally by an implant zone (16). The implant zone (16) being a space defined by an excised portion of a subject's spinal cord (18). The neural basal and neural induction medium mixture (20) provides nutrients for the development of the stem cells (14) and the growth factors, in form of neurotrophin 3, neurotrophin 4 and brain-derived neurotrophic factor (BDNF) encourage and control development of the stem cells (14), the growth factors typically being constituents of the medium mixture (20).

AUTOMATIC DESIGN OF CUSTOM EAR DEVICES

Resumen de: WO2024200441A1

Described herein is a computer-implemented method for constructing in the form of designing in a virtual environment a custom ear device in an automated process utilizing a trained neural network. The computer-implemented method described is configured to allow for changing the output form the neural network to create change to an automatic generated custom ear device design. Furthermore, described herein is a system utilizing a processor running the method described herein to automatically generate virtually constructed custom ear devices that may be modified to adjust for any incorrect outputs generated by a neural network.

SPINAL IMPLANTS WITH CUSTOM DENSITY AND 3-D PRINTING OF SPINAL IMPLANTS

Resumen de: EP4691507A2

In some embodiments, a spinal implant (10, 110, 210, 310, 400) is provided and includes a body portion defining a longitudinal axis. The body portion includes a distal end portion, a proximal end portion, opposed side surfaces that extend between the distal and proximal end portions, and top and bottom surfaces configured and adapted to engage vertebral bodies. The top and bottom surfaces have a surface roughness between 3-4 µm. A cavity extends through the top and bottom surfaces defining a surface area that is at least 25% of a surface area of the top surface or the bottom surface. First orifices (24, 124, 224, 324, 426a) are defined through the top surface and second orifices (34, 134, 234, 334, 426b) are defined through the bottom surface. The second orifices are connected to the first orifices by a plurality of channels.

ADDITIVE MANUFACTURING PART SUPPORT AND HANDLING FRAME

Resumen de: EP4691381A1

A cutting instrument including an insert and a frame having sidewalls that extend from a base and define a slot. The slot is configured to receive a portion of the insert such that an edge of the insert extends beyond the frame. The sidewalls are configured to shrink around a portion of the insert such that an edge of the insert extends beyond the frame. Additionally, a method for fabricating a cutting instrument including depositing layers of metal powder onto a base and selectively binding the deposited layers of the metal powder onto the base to form a frame attached to the base. Next, placing an insert within the frame such that a portion of the insert extends beyond the frame and the combination of the base, the frame, and the insert forms an in-process assembly.

INVERTED CONTACT-AIDED ROLLING ELEMENT MECHANISMS AND DEVICES

Resumen de: WO2024211902A1

Inverted contact-aided rolling element mechanisms and devices are discussed herein. In various embodiments, the contact-aided compliant mechanism includes a first rigid component, a second rigid component, a first flexible component, a second flexible component, each of the first and second flexible components comprising a first end, a second end, and a third end, and the first and second flexible components disposed between the first and second rigid components.

TECHNIQUES FOR AUTOMATED MARKING OF DENTAL APPLIANCES

Resumen de: MX2025011659A

The present disclosure discusses techniques for marking a dental appliance. A dental model and dental appliance are positioned onto a conveyor tray, which is transported to a scan station. The dental model and conveyor tray each include an identifying code. The scan station includes a camera and barcode reader to read the identifying codes on the dental model and conveyor tray, and these codes are associated with one another. The conveyor tray then moves to a marking station where a barcode reader reads the code on the conveyor tray, and then marks the dental appliance with the appropriate marking.

一种虎杖苷腱骨修复梯度仿生支架及其制备方法

Resumen de: CN121490141A

本发明公开了一种虎杖苷腱骨修复梯度仿生支架及其制备方法，将纳米羟基磷灰石（nHAP）/聚己内酯（PCL）复合材料与含有虎杖苷（PLD）脂质体的生物水凝胶两种材料，通过3D打印设计与制备构建成多分区结构，以此满足腱骨愈合的复杂要求。其中nHAP/PCL复合材料良好机械性能匹配肌腱受力环境，作为支架的力学框架。nHAP的引入能有效促进骨损伤区域的愈合，缓释PLD脂质体水凝胶的构建可以有效逆转腱‑骨界面的纤维化。本发明通过3D打印技术所构建的缓释虎杖苷的梯度仿生支架能为腱骨愈合带来全新的治疗方案。

一种制造硅胶托槽矫治器的方法

Resumen de: CN121489670A

本申请提供一种制造硅胶托槽矫治器的方法，包括：获取当前状态下的牙齿形态数据；根据所述牙齿形态数据获得针对需要矫正牙齿的托槽形态数据；根据所述托槽形态数据获得托槽装配牙齿后的装配模拟数据；根据所述装配模拟数据获得制造硅胶托槽矫治器的打印数据，并根据所述打印数据对硅胶材料加热固化以形成硅胶托槽矫治器，所述硅胶托槽矫治器至少包括容装牙齿的牙套和设置在所述牙套壁体上的用于容装托槽的容置凹槽。

一种抗菌可降解的骨固定支架及其制备方法

Resumen de: CN121490139A

本发明属于生物医学工程技术领域，公开了一种抗菌可降解的骨固定支架及其制备方法。本发明将壳聚糖、nHAP、rGO和纳米MgO进行复合，形成多元复合材料体系，不仅提高了支架的力学性能，还实现降解速率的调控；加入纳米MgO，实现了支架降解速率与骨组织再生速度的匹配，避免了传统支架过早降解导致支撑失效的问题。并且，本发明采用PDA涂层与AgNPs负载的双功能表面改性工艺，既解决了壳聚糖表面光滑导致的抗菌剂负载量低的问题，又避免了单一抗菌剂可能导致的耐药性。采用低温3D打印制备支架，有效保持壳聚糖的生物活性，优化浆料性能和打印参数实现了复杂结构的精准成型，为个性化骨固定支架提供了基础。

一种用于慢性创面修复的智能响应性生物材料及其制剂

Resumen de: CN121490121A

本发明涉及生物医用材料制造领域，公开了一种用于慢性创面修复的智能响应性生物材料及其制剂，制剂具有早期响应层与晚期修复层的功能分区材料，通过生物医用增材制造方法制备，该方法利用含弹性蛋白样区的智能响应型重组多域蛋白作为温敏生物墨水组分，设定打印喷头温度低于其相变温度而基板平台温度高于其相变温度，驱动生物墨水温敏相变原位固化以成型分区，解决活性分子在均质制剂中功能释放的时序性错乱问题，保障早期抗菌与晚期修复功能的执行。

一种成骨技术用3D打印方法及个性化箱型钛板

Resumen de: CN121491360A

本发明公开了一种成骨技术用3D打印方法及个性化箱型钛板，本发明涉及医疗器械的制作领域，具体包括以下步骤：S1：患者颌骨三维数据的获取与预处理；S2：骨缺损前理想轮廓的三维重建与虚拟修复；S3：个性化箱型钛板的数字化设计；S4：3D打印制造个性化箱型钛板；S5：手术中的临床应用。本发明所述的一种成骨技术用3D打印方法及个性化箱型钛板，个性化箱型钛板在手术中可实现被动就位，即其形态与骨缺损区天然契合，放置后即能完美恢复理想的骨弓轮廓。这降低了对医生个人技术的依赖性，使手术结果更具可预测性和可重复性，由于箱型钛板通过螺钉直接固定于残留的健康基骨上，其固定稳定性远胜于骨块。

渐变色牙齿修复体三维打印方法及系统

Resumen de: CN121492351A

本发明涉及牙齿修复技术领域，具体涉及渐变色牙齿修复体三维打印方法及系统。本发明将待修复的目标牙的修复体模型划分为多个牙体修复层，并以健康邻牙的牙体颜色变化数据作为参照，确定每个牙体修复层的目标颜色，然后对所有牙体修复层的目标颜色按照由浅到深的规则进行排序以作为打印顺序；最后以所述目标颜色为打印目标，基于预先设定的配色供料策略和曝光控制策略，按照所述打印顺序依次对修复体模型的各个牙体修复层进行三维打印以得到目标牙的渐变色牙齿修复体，从而得到与健康邻牙色差较小的渐变色牙齿修复体，修复效果较佳。

一种声学超表面的设计与加工方法、针形聚焦声束成像探头、方法及系统

Resumen de: CN121489530A

本发明涉及一种声学超表面的设计与加工方法、针形聚焦声束成像探头、方法及系统，属于超声医疗领域。通过超表面将平面超声波聚焦为针形聚焦声束，以线性扫描的形式进行成像，可以在保证成像精度的同时实现快速超声成像，从而解决现有技术中超声成像技术中无法兼顾成像质量和成像速度的难题。本发明中提出的声超表面的针形聚焦声束成像系统通过机械扫描系统、发射电路以及波束成形系统之间的数据实时数据交互，可实现低成本快速超声成像，并且成像质量更高。

一种仿生异质性组织工程半月板支架及其制备方法

Resumen de: CN121490140A

本发明公开了一种仿生异质性组织工程半月板支架及其制备方法，并揭示其在半月板修复领域的应用。基于多喷头3D打印技术，创新采用生物可降解高分子材料与负载生长因子/干细胞的生物墨水，构建高度仿生的异质性组织工程半月板。具体而言，以可降解高分子聚己内酯（PCL）为原料，通过精准调控打印路径，模拟天然半月板胶原纤维分布规律，打印环向与径向纤维形成支架框架；在此基础上，针对半月板红区与白区不同生理特性，交错打印负载差异化生长因子及干细胞的生物墨水，实现种子细胞的分区精准接种与生长因子的可控分区释放，为半月板再生提供具备空间特异性的细胞微环境，显著提升组织修复效率与仿生契合度。

3D辅助下光线引导穿刺定向成套器械及其定向方法

Resumen de: CN121465686A

3D辅助下光线引导穿刺定向成套器械及其定向方法，属于医疗器械领域，发明包括设置在患者头皮且光线朝向患者头部的两个红外线或激光线性定位灯，两个线性定位灯通过角度调节装置设置在一个或两个支架上，所述两个线性定位灯的灯光可在头皮外周任意角度调节，两个线性定位灯的线性灯光在不同方向上，两个线性定位灯形成的线性光线分别经过患者头皮外周的两个定位标记，穿刺导管设置在头部外穿刺中心线的延长线上，穿刺辅助架支撑着穿刺导管，本发明可应对多种脑病灶穿刺定向，避免手术器械与患者面部与五官部位接触带来的伤害，可精准快速定向。

超结构玻璃碳在促骨修复中的应用及骨修复材料的制备方法

Resumen de: CN121466359A

本发明属于材料制备技术领域，具体涉及一种超结构玻璃碳在促骨修复中的应用及骨修复材料的制备方法。本发明首先提供了一种骨修复材料，所述骨修复材料由一种经过表面改性的玻璃碳材料制备得到；所述玻璃碳材料具有各向应力均匀分布的稳定结构；所述超结构玻璃碳以三周期极小曲面的晶胞作为最小重复单元；经过表面改性后的玻璃碳材料具有珊瑚样或类珊瑚样形貌。本发明的骨修复材料可以实现诱导骨组织加速修复和再生，此外这种骨修复材料还兼顾了很好的力学性能。

一种修复膜及其制备方法

Resumen de: WO2025055408A1

The present invention relates to the technical field of biomaterials. Disclosed are a repair membrane and a preparation method therefor. The preparation method comprises the following steps: S1, preparing a polymer membrane; S2, mixing the polymer membrane with a natural polymer material solution, and performing unidirectional freezing to prepare a through hole structure; and S3, cross-linking a composite membrane of a polymer and a natural polymer material to obtain a repair membrane. According to the repair membrane and the preparation method therefor provided by the present invention, the repair membrane prepared takes a polymer material as a support and slow-degradation inner layer and takes a cross-linked natural polymer material having a unidirectional channel as a guide outer layer. When the present application is applied to repair of soft tissues such as smooth muscle, blood vessels, and tendons, a gelatin unidirectional channel can guide directed cell migration, adhesion, proliferation, and alignment, and a polymer of an inner layer can ensure the matching between the degradation rate of the material and tissue growth, so that the present invention can achieve a better tissue repair effect.

一种适用于增材制造的骨骼材料及其制备方法

Resumen de: CN121466360A

本发明公开一种适用于增材制造的骨骼材料及其制备方法，方法包括以下步骤：S1、将CNTs加入乙醇中，搅拌，超声分散，获得CNTs乙醇分散液；S2、将PEEK粉体加入CNTs乙醇分散液中，搅拌，超声分散，获得CNTs‑PEEK‑乙醇共混液；S3、将CNTs‑PEEK‑乙醇共混液搅拌直至重量不再减少，获得CNTs‑PEEK粉体；S4、将CNTs‑PEEK粉体烘干后，挤出，获得CNTs‑PEEK线材；S5、将CNTs‑PEEK线材再次烘干后，利用高温融熔挤出打印，获得个性化骨骼支架；本发明提供了一种适用于增材制造的、力学性能好且不容易脆性断裂的骨骼材料及其制备方法。

一种仿生骨支架定制体及其制备方法与应用

Resumen de: CN121468962A

本发明涉及一种仿生骨支架定制体及其制备方法与应用，属于生物医药材料技术领域。本发明提供了仿生骨支架定制体的制备方法，包括以下步骤：扫描记录颅颌面硬组织缺损形态，基于所记录得到的数据通过算法模型和/或人工设计构建得到数字化支架模型；所得数字化支架模型进行三维重建，生成符合颅颌面组织缺损个性化需求的仿生骨支架定制体数据；利用3D打印技术将所得仿生骨支架定制体数据转化为仿生骨支架定制体。本发明利用真实骨缺损数据进行建模，通过3D打印技术制备骨缺损部位的仿生骨支架定制体，外轮廓与骨缺损侧形态贴合并重建骨理想形态，内轮廓为缺损部位的精细亚结构，具备仿生孔隙结构和生物力学性能，可用于重建个性化颅颌面组织。

基于耳廓扫描与3D打印的耳穴电刺激戒烟仪及使用方法

Nº publicación: CN121466489A 06/02/2026

Solicitante:

中日友好医院（中日友好临床医学研究所）

Resumen de: CN121466489A

一种基于耳廓扫描与3D打印的耳穴电刺激戒烟仪及使用方法，能够贴合个体的耳型，使电极或刺激凸点能准确对应穴位，实现电刺激的精准定位与标准化操作，模拟针刺“得气”效应，增强戒断症状缓解与渴求抑制效果，实时监测佩戴时长、刺激次数与依从性，为医生提供客观量化的数据。其包括：三维扫描与个体建模模块，3D打印个体化耳夹主体，电刺激控制模块，信号输出与控制单元。