Bioimpressió 3D

System of multiple interlocking embedment

Resumen de: GB2635903A

An oral dosage tablet for delivery of hydrophobic active ingredients to a patient and method of forming the same are described. The oral dosage tablet includes one or more layers of an active ingredient adjacent one or more layers of a lipid, such as a phospholipid. The layers are alternating and have a thickness of between 0.1 and 0.8 millimeters. The method of forming the tablet includes forming a lipid paste and an active ingredient paste of the respective components and applying alternating layers of each in layers of between 0.1 millimeters to 0.8 millimeters. The oral dosage tablet is subsequently dried and stored until treatment commences.

DOUBLE NETWORKED 3D-PRINTED BIOMATERIALS

Resumen de: WO2024026023A2

A 3D-printed biomaterial is described that comprises a double-networked hydrogel comprising gelatin or gelatin methacryloyl and alginate, and cells. Methods of making the 3D-printed biomaterial by extruding a hydrogel comprising gelatin or gelatin methacryloyl and alginate from a 3D-printer and converting the hydrogel to a double-networked hydrogel by cross-linking the gelatin with a first cross-linking method and cross-linking the alginate with a second cross-linking method are also described. Methods of treating a damaged or diseased blood vessel and testing vasoactive drugs using 3D-printed blood vessels are also described.

SYSTEM AND METHOD FOR ENHANCED AEROSOL DRUG DELIVERY DURING HIGH FLOW NASAL CANNULA THERAPY

Resumen de: WO2024026093A1

A system and method for enhanced aerosol drug delivery during high flow nasal cannula (HFNC) therapy. The system comprises a breath enhanced jet nebulizer (BEJN) connected to a high flow medical breathing gas supply supplying breathing gas to the BEJN at flow rates of 5 L/min to 60 L/min, a nebulization gas supply, a drug infusion device that supplies a drug solution to the nebulizer for the delivery of nebulized drug to a patient. All the breathing gas and nebulized drug solution delivered to the patient passes through the BEJN. The rate of drug delivery increases with increases in the flow rate of the medical breathing gas supply and increases in infusion pump flow rates. The drug solution infusion rate is between 5 mL/hour and 50 mL/hour. This system and method enable efficient aerosol drug delivery to patients during HFNC therapy for prolonged periods, improving treatment outcomes.

BIOENGINEERING PATIENT-SPECIFIC 3D-PRINTED CARTILAGE IMPLANTS

Resumen de: WO2024028882A1

The invention related to an implant comprising a scaffold comprising at least one first area characterized by micropores and at least one second area characterized by macropores, wherein said at least one second area is defined by being expected to be exposed to higher pressures and/or forces when compared with said at least one first area, and methods thereof.

Drug-eluting surgical articles and methods of use thereof

Resumen de: GB2635973A

Disclosed herein is a biomaterial and a method of use thereof for treating a condition; the biomaterial comprises a first porous polymer, a second non-porous polymer, and a therapeutic agent. A biomaterial of the disclosure can be, for example, a surgical article. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer.

一种牙齿修复装置

Resumen de: CN120078618A

本发明公开一种牙齿修复装置，涉及医疗器械技术领域，包括支撑板，支撑板顶面固定安装有操作台，操作台上设有用于设置参数的触摸显示屏，操作台内安装有3D打印机，操作台上开设有第二凹槽，第二凹槽内放置有扫描仪，扫描仪用于对患者口腔进行非接触式扫描，操作台远离扫描仪的一侧开设有第一凹槽，第一凹槽内放置有安装笔，安装笔用于将修复体装入需要修复的牙齿内，操作台上开设有盛放槽，盛放槽用于放置修复体。本发明能够一次性完成从扫描到安装的全过程，显著缩短治疗周期，提高效率；减少就诊次数和手术创伤，提升患者治疗体验，增强舒适度；通过安装笔对修复体进行固定安装，保证与牙齿良好的贴合度。

一种3D打印生物墨水、矿化支架及制备方法和在矿化组织分级再生中的应用

Resumen de: CN120078947A

本发明提供了一种3D打印生物墨水、矿化支架及制备方法和在矿化组织分级再生中的应用，属于骨组织工程材料技术领域。本发明首先制备具有仿生形状和多孔网络的有机质微囊，通过引入多酚成核位点，矿化沉积迅速在微囊中发生，形成骨样羟基磷灰石纳米片聚集体，然后将其作为生物墨水的主要功能性单元，微囊经有机质连续相稳定组装，实现了植入体中矿化成核位点数量和生长域的个性化精准可控。通过3D打印制备矿化支架，本发明提供的矿化支架，在微囊内可形成丰富均质的矿化生长域，可有效促进间骨髓充质干细胞长入并形成矿化结节成为人工骨化中心，加快新生组织原位矿化和骨再生进程。

一种可拆卸3D打印义齿的个性化适配卡扣

Resumen de: CN222929860U

本实用新型公开了一种可拆卸3D打印义齿的个性化适配卡扣，包括固定在义齿本体两侧的用于与相邻牙齿卡设安装的卡环，还包括设置在义齿本体上的用于义齿本体安装过程中与相邻牙齿之间适配挤压的适配挤压组件。本实用新型的一种可拆卸3D打印义齿的个性化适配卡扣，义齿在安装的过程中，通过传动，使两组挤压板的一端分别与义齿本体两侧相邻的牙齿相抵，通过相抵作用，对安装后的义齿本体进行自动的适配挤压，且在挤压适配的过程中，推动弹簧的弹力作用，使两组挤压板保持与相邻两组牙齿相抵，避免因使用者口腔的变化造成安装后义齿本体与相邻的牙齿之间产生间隙，便于义齿本体以更加稳定的卡扣方式安装固定。

基于数字化可视化颌位重建技术的矫治器制作方法

Resumen de: CN120078532A

本发明涉及骨性Ⅲ类上颌发育不足的矫治器技术领域，尤其涉及一种基于数字化可视化颌位重建技术的矫治器制作方法，所述矫治器包括基底和颌垫，矫治器的制作包括以下步骤：S1：获取患者相关数据及第一次口扫数据，确定矫治器方案；S2：获取患者的静态咬合状态，确定初步的咬合目标位置，并获得第二次口扫数据；S3：将所述第一次口扫数据和所述第二次口扫数据分别导入至设计软件中，生成数字化模型；S4：通过数字化颌架确定最终颌位；S5：设计基底模型，并3D打印；S6：设计颌垫模型，并3D打印；本方法制作的矫治器组织面能完美匹配患者的牙齿外形，咬合记录目标位置更加符合人体生物学基础，设计更为精确，并可有效防止矫治器脱落。

促进骨质疏松性骨缺损修复的人工骨及其制备方法

Resumen de: CN120078956A

促进骨质疏松性骨缺损修复的人工骨及其制备方法，属于生物医学材料技术领域。本发明的人工骨由89.65wt%‑89.85wt%的聚乳酸‑羟基乙酸共聚物、9.85wt%‑10.15wt%的纳米羟基磷灰石以及0.1wt%‑0.5wt%的唑来膦酸复合而成。该人工骨中，纳米羟基磷灰石和唑来膦酸在聚乳酸‑羟基乙酸共聚物中均匀分散，结合人工骨表面的多孔结构，有利于成骨细胞在表面的附着，有利于新生骨组织的长入；唑来膦酸的膦酸根能够与纳米羟基磷灰石螯合生成稳定的化学键，将其引入到聚乳酸‑羟基乙酸共聚物中，可以实现唑来膦酸的有效负载，唑来膦酸的有效负载能够抑制破骨细胞过度活化导致的骨吸收增多，修复骨质疏松性骨缺损。

一种防移位自适应自锁式人体管腔支架与制作方法

Resumen de: CN120078562A

本发明涉及一种防移位自适应自锁式人体管腔支架与制作方法，属于医疗器械领域。本发明包括支架单元和连接单元，相邻支架单元通过连接单元连接，其结构特点在于：所述支架单元包括呈菱形结构设置的主体框架、以及设置在主体框架内部的连接横梁、过渡横梁和榫卯横梁，所述连接横梁、过渡横梁和榫卯横梁依次连接，所述连接横梁和榫卯横梁均与主体框架连接，两个榫卯横梁上均设置有多个榫头，相邻榫头之间形成榫槽，其中一个榫卯横梁上的榫头与另一个榫卯横梁上的榫槽连接，其中榫头的数量不少于3个，榫槽的数量不少于2个。

一种可紫外光固化的仿生半月板及其制备方法

Resumen de: CN120078942A

本发明公开了一种可紫外光固化的仿生半月板及其制备方法，涉及半月板组织替代物技术领域，仿生半月板的形状为模拟天然半月板的C形结构，仿生半月板的C形结构由前至后依次分为前部、中部和后部，仿生半月板的表面强度沿着前部到中部方向梯度增加，沿着中部到后部方向梯度下降；仿生半月板的C形结由内至外依次分为内侧、中间和外侧，仿生半月板的表面强度在前部和中部区域沿着外侧到中间方向梯度增加，沿着中间到内侧方向梯度下降；仿生半月板的表面强度在后部区域沿着外侧到内侧梯度下降；仿生半月板采用可紫外光交联的材料固化后制得。本发明使用紫外光固化材料制备不可降解的具有梯度强度分布的仿生半月板，其与天然半月板的力学性能相近。

一种光敏树脂组合物、树脂牙及树脂牙的制备方法

Resumen de: CN120081983A

本发明提供了一种光敏树脂组合物、树脂牙及树脂牙的制备方法。所述光敏树脂组合物包括如下质量百分比的组分：聚氨酯(甲基)丙烯酸酯类低聚物20～45％、单官能(甲基)丙烯酸酯单体5％～15％、多官能(甲基)丙烯酸酯单体10～30％、填料15～55％、引发剂1％～5％、紫外线吸收剂0.02％～0.12％和光稳定剂0.1％～0.3％。所述树脂牙由所述光敏树脂组合物通过光固化3D打印制备得到。采用本发明提供的光敏树脂组合物制备的树脂牙具有在口腔环境下力学性能稳定，在咀嚼循环条件下的耐疲劳性能良好的优点。

用于基于光的生物打印应用的生物墨水水溶液以及使用该生物墨水水溶液的方法

Resumen de: WO2024084040A1

The disclosure relates to an aqueous bioink solution for use in light-based bioprinting applications, comprising: (a) 0.5-95 wt % water-soluble prepolymer; (b) 0.001-5 wt % biocompatible metal acylphosphinate photoinitiator; (c) 0.001-10 wt % biocompatible light absorber; and (d) 5 to 99.5 wt % solvent. The disclosure further relates to a method of using the aqueous bioink solution including living cells and a method of using the aqueous bioink solution without living cells (acellularly).

一种3D打印骨小梁口腔种植体的方法

Resumen de: CN115740495A

The invention relates to a method for 3D printing of a bone trabecula oral implant. The bone trabecula oral implant comprises an implant base body and a bone trabecula porous structure which are integrally formed. The bone trabecula porous structure is positioned in the axial middle section of the implant base body; and the implant base body is provided with an external thread. The printing method comprises the following steps: obtaining an oral implant 3D model with a bone trabecula porous structure through three-dimensional design software; carrying out molding manufacturing, sand blasting and annealing treatment by utilizing an SLM technology to obtain a bone trabecula oral implant primary product; and forming a tantalum metal coating on the surface of the primary product of the bone trabecula oral implant by using a vapor deposition technology to obtain the bone trabecula oral implant with the tantalum coating. The bone trabecula oral implant obtained by the method is high in density and mechanical strength, favorable for the implant to exert a good repairing effect, and excellent in application prospect.

一种基于数字化导板引导的前牙分层树脂充填修复方法

Resumen de: CN120078530A

本发明属于口腔修复数字化领域，具体涉及一种基于数字化导板引导的前牙分层树脂充填修复方法。包括以下步骤：S1、获得基牙预备体的三维数字化模型；S2、利用口腔计算机辅助设计软件逐层生成缺损部分的牙本质形态的数字化模型；S3、在最后一层牙体缺损部分牙本质形态的数字化模型上完成牙釉质层形态的设计；S4、设计覆盖缺损牙邻牙的盖壳式导板，并对各盖壳式导板进行编号；S5、将各层模型和导板3D打印出来，并检查导板的就位情况；S6、在各级导板中填充相应的牙本质树脂和牙釉质树脂，将充填树脂的导板复位至口腔牙列，通过光照固化完成分层树脂充填。本发明优化了流程，简化了操作，充分利用数字化技术的优势保证了操作精度。

微针阵列和制造方法

Resumen de: WO2024040387A1

A microneedle array (101) comprises a surface (102) and two or more microneedles (104, 105) extending from the surface, wherein at least one of the microneedles has a different shape and/or length compared with a shape and/or length of at least one other of the microneedles. Furthermore method of making.

ADDITIVE MANUFACTURING OF RADIOLOGICAL PHANTOMS

Resumen de: US2025152121A1

A formulation usable as a modeling material formulation in additive manufacturing of a three-dimensional object and additive manufacturing methods utilizing same are provided. The formulation comprises one or more curable materials; and a radiopaque material, and features, when hardened, a CT number of at least 100 HU at 70 kV. Objects made by the additive manufacturing method utilizing the formulation are usable as radiological phantoms.

SYSTEM AND METHOD FOR PRODUCING PHARMACEUTICAL OBJECTS VIA 3D PRINTING

Resumen de: EP4523890A2

The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D printing. The system comprises a 3D printing machine (2) with a mechanical system (3) movable in one or more directions, at least one print head (5) with at least one nozzle (37) being movable by the mechanical system (3) and a base system (4) carrying a print base (6) for receiving a prepared mixture (27) applied by the print head (5) and comprising formatted print locations (49) on the base (6) for shaping the pharmaceutical object. The formatted print locations (49) can be adapted to receive a blister such that the pharmaceutical objects can be printed directly inside the blister. The system can further comprise a closing device for applying a sealing membrane or film to hermetically seal the blister after the printing is completed. The invention further relates to a method for producing pharmaceutical objects with the system.

TRANSPARENT, FRACTURE-RESISTANT POLYMERISATION RESINS FOR THE PRODUCTION OF DENTAL MOULDINGS

Resumen de: US2022370300A1

Radically polymerizable dental material, which contains at least one ABA or AB block copolymer, preferably at least one monofunctional, radically polymerizable monomer (a) and preferably at least one radically polymerizable urethane di(meth)acrylate telechel (b).

Spherical tantalum powder, products containing the same, and methods of making the same

Resumen de: JP2024045166A

To provide a method for forming articles by additive manufacturing using tantalum powder.SOLUTION: There is provided a method for forming an article, wherein the method comprises a step of additive manufacturing to form the article by utilizing the tantalum powder to form the shape of the article or part thereof, and wherein the tantalum powder has following characteristics: a. spherical shape with an average aspect ratio of from 1.0 to 1.25; b. a purity of tantalum of at least 99.99 wt.% Ta based on total weight of the tantalum powder, excluding gas impurities; c. an average particle size of from about 0.5 micron to about 250 microns; d. an apparent density of from about 4 g/cc to about 12.3 g/cc; e. a true density of from 16 g/cc to 16.6 g/cc; and f. a Hall flow rate of 20 seconds or less.SELECTED DRAWING: Figure I

Impact resistant material

Resumen de: AU2025202262A1

The current disclosure is directed to an impact resistant material made from a novel melanin composite. It has been found that using these composites allows for the production of effective ballistic protection and blast containment materials.

バイオプリント線維構造を製造するためのシステム及び方法

Resumen de: AU2023271390A1

Aspects of the disclosure include a fabrication platform for supporting a bioprinted fiber structures during printing, patterning, and/or processing, comprising a frame with a plurality of posts for securing a cross-linkable fiber during printing thereof, and where a continuous length of the cross-linkable fiber is printed around a plurality of posts during the 3D bioprinting process. The fabrication platform enables the cross-linkable fiber to be suspended during one or more of printing, patterning, and/or processing. In this way, the bioprinted fiber structure comprises a uniform outer surface, and can be easily modified and/or further processed after printing and patterning are completed.

薬物溶出外科用物品およびその使用方法

Resumen de: CN119546355A

A biological material comprising a first porous polymer, a second non-porous polymer, and a therapeutic agent, and a method of using the same for treating a condition are disclosed. The biomaterials disclosed herein may be, for example, surgical articles. Implanting the biomaterials disclosed herein in a subject can treat, for example, cancer.

CONTRAST MARKERS FOR USE IN MEDICAL PROCEDURES

Nº publicación: WO2025111433A1 30/05/2025

Solicitante:

WAKE FOREST UNIV HEALTH SCIENCES [US]
WAKE FOREST UNIVERSITY HEALTH SCIENCES