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Resultados 154 resultados
LastUpdate Última actualización 03/05/2026 [08:01:00]
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Solicitudes publicadas en los últimos 60 días / Last 60 days publications
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KINASE INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

NºPublicación:  US20260062413A1 05/03/2026
Solicitante: 
OHIO STATE INNOVATION FOUND [US]
REACTION BIOLOGY CORP [US]
Ohio State Innovation Foundation,
Reaction Biology Corporation
US_20260062413_A1

Resumen de: US20260062413A1

Provided are compounds that are kinase inhibitors. The compounds have improved properties that lead to specific targeting of kinases without inhibiting the activity of related enzymes, which make them useful for therapeutic intervention in a variety of disorders and disease in which inhibition of the kinase can be clinically useful, e.g., Alzheimer's disease and other neurodegenerative diseases. The compounds can also be used in methods of treating a neurodegenerative disease associated with inflammation, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, epilepsy, stroke, amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), or a disease or disorder such as deafness, glaucoma, organ failure, or cancers, including, but not limited to, those susceptible to combination therapy with epigenetic targets such as those associated with bromodomain (BRD) proteins, histone deacetylases (HDACs), and the like.

IN VIVO IMAGING OF AN ALS BIOMARKER AND MEANS THEREFOR

NºPublicación:  EP4702057A1 04/03/2026
Solicitante: 
AL S PHARMA AG [CH]
EP_1000000_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

TRICYCLIC FUSED IMIDAZOLE COMPOUNDS AS CD38 MODULATORS AND USES THEREOF

NºPublicación:  EP4702026A1 04/03/2026
Solicitante: 
AEOVIAN PHARMACEUTICALS INC [US]
EP_1000000_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

AGENT FOR TREATING OR PREVENTING AMYOTROPHIC LATERAL SCLEROSIS

Nº publicación: EP4702978A1 04/03/2026

Solicitante:

SOCIUM INC [JP]
Socium Inc

EP_4702978_PA

Resumen de: EP4702978A1

An agent for treating or preventing amyotrophic lateral sclerosis, wherein an active component of the agent essentially consists of at least one selected from the group consisting of cycloserine, terizidone, and salts thereof. The active component may consist of at least one selected from the group consisting of cycloserine, terizidone, and salts thereof. The cycloserine may be D-cycloserine. The cycloserine may be L-cycloserine.

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