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LastUpdate Última actualización 29/10/2026 [08:34:00]
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Methods Of Treating Metabolic Disorders And Cardiovascular Disease With Inhibin Subunit Beta E (INHBE) Inhibitors

NºPublicación:  US20260191897A1 09/07/2026
Solicitante: 
REGENERON PHARMACEUTICALS INC [US]
Regeneron Pharmaceuticals, Inc.
US_20260191897_A1

Resumen de: US20260191897A1

0000 The present disclosure provides methods of treating a subject having metabolic disorders and/or cardiovascular diseases, methods of identifying subjects having an increased risk of developing a metabolic disorder and/or a cardiovascular disease, and methods of detecting human Inhibin Subunit Beta E variant nucleic acid molecules and variant polypeptides.

ASSESSMENT AND DIFFERENTIAL DIAGNOSIS OF CARDIOVASCULAR DISEASE IN COMPANION ANIMALS USING A MICRORNA ASSAY

NºPublicación:  EP4771186A1 08/07/2026
Solicitante: 
MI RNA LTD [GB]
MI:RNA LTD
WO_2025046293_A1

Resumen de: WO2025046293A1

A method of assessing expression profiles of miRNA markers using predictive classification models to differentially diagnosing MMVD patients from healthy controls or DCM patients from healthy controls. Additionally, an assessment of the same method to discriminate pre-clinical from clinical MMVD or DCM patients. Also provided is a method of differentially diagnosing MMVD patients from DCM patients or from healthy controls.

Application of SnoRNA Gm26330 as myocardial hypertrophy biomarker and therapeutic target

Nº publicación: CN122326737A 03/07/2026

Solicitante:

SHANDONG SECOND MEDICAL UNIV
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CN_122326737_PA

Resumen de: CN122326737A

The invention belongs to the field of biomedical engineering, and relates to an application of SnoRNA Gm26330 as a myocardial hypertrophy biomarker and a therapeutic target. The invention provides a marker snoRNA (ribonucleic acid) Gm26330 related to myocardial hypertrophy, wherein the nucleotide sequence of the snoRNA Gm26330 is as shown in SEQ ID No. 1. The invention also provides a kit for detecting myocardial hypertrophy. In-vivo and in-vitro experiments show that the SnoRNA Gm26330 can inhibit the cardiac hypertrophy, the SnoRNA Gm26330 has a protection effect on myocardial damage caused by the cardiac hypertrophy, and the SnoRNA Gm26330 has a potential value for preparing the medicine for preventing and treating the related heart diseases.

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