Resumen de: WO2026046968A1
Subject of the invention are DPP3 binders for use in therapy or prevention of endothelial dysfunction in a patient wherein the level of Pro-Adrenomedullin or a fragment thereof in a sample of bodily fluid obtained from said patient is above a threshold, as well as methods of therapy guidance or therapy stratification or therapy monitoring of a treatment of a patient with a DPP3 binder, the methods comprising: providing a sample of bodily fluid of said patient; determining the level of Pro-Adrenomedullin or a fragment thereof in said sample; and comparing said level of Pro-Adrenomedullin or a fragment thereof to a threshold; wherein the level of Pro-Adrenomedullin or a fragment thereof in said sample being above said threshold is indicative that said patient requires treatment with a DPP3 binder, or wherein if said level of Pro-Adrenomedullin or a fragment thereof in said sample is above said threshold, said patient is treated with a DPP3 binder.
Resumen de: WO2026047621A1
Provided is a method that involves inhibiting expression of UHRF1 in liver cells of an individual. Inhibiting the expression of UHRF1 promotes an inhibition of reduction of bone density or an increase in bone density, or inhibition of weight gain or a reduction in adipose mass, or inhibition of development of gray hair or an increase in activity level, or a decrease in biological age or enhanced liver regeneration, or increased survival following partial hepatectomy, or a combination of such effects.
Resumen de: WO2026050159A1
Provided herein are methods for enriching tumor derived EVs or brain-derived EVs from a biological sample, e.g. a biofluid, using a lectin or glycan-binding fragment thereof and an isolation component (e.g., a solid media). The present disclosure also provides compositions and kits for isolating brain-derived EVs or tumor derived EVs, and compositions comprising an isolated population of brain-derived EVs or tumor derived EVs.
Resumen de: WO2026050297A2
The present disclosure relates to compositions comprising modified heat shock proteins conjugated to a humanized 3E10 antibody or antigen-binding fragment thereof as well as methods of using the same to treat blast injury to the eye, brain, and cochlea.
Resumen de: WO2026047150A1
The invention relates to methods of tracking fatty acids and/or fatty acyl chains between an origin cell and one or more destination cells or locations in a multicellular structure, methods of diagnosis and screening related thereto, and nucleic acids encoding cyclopropane fatty acid synthase for use therein.
Resumen de: EP4459287A1
The present invention covers an in vitro method for evaluating the ability of a compound to disrupt or stabilize an interaction between one or more bait and one or more candidate prey in a eukaryotic cell. In addition, the present invention covers compounds identified by the in vitro method according to any one of the preceding claims, for use as a medicament.
Resumen de: WO2026050631A1
A lentivlral vector for real-time monitoring of cell state which includes a regulatory element that regulates expression of a selection marker, wherein the regulatory element comprises cell-state-specific histone H3K27-acetylation marks and/or chromatin accessibility. Methods of identifying a cell- state-specific regulatory element in a cell; optically screening a compound for the ability to modify cell identity; in vivo labeling normal and/or diseased cells at a specific developmental stage or a specific stage of disease; and real- time monitoring of transcription of a cell exposed to a stress using the lentiviral vector.
Resumen de: WO2026047343A1
The present invention is directed to a method of identifying genomic nucleic acid regions associated with chromatin marks, genome binding proteins and/or genomic modifications, and the transcriptome in a sample, said method comprising in situ single step fragmentation and adapter sequence insertion using individual anti-chromatin mark, anti-genome binding protein and/or anti-genomic modification antibody-transposase-adapter complexes, each of said complexes comprising one or more antibodies specific for a chromatin mark, genome binding protein and/or genomic modification of interest with an indexed transposase-adapter sequence, and mRNA transcript capture and in situ reverse transcription. Also provided are methods of identifying chromatin marked, genome binding protein bound and/or modified genomic nucleic acid regions associated with a particular disease state and/or a particular state of developmental differentiation, as well as kits for performing the methods herein.
Resumen de: WO2026046058A1
A method of characterizing a peptide using a nanopore incorporating at least one metal ion as a sensing moiety. A method of profiling or sequencing a polypeptide by fragmenting the polypeptide and then characterizing the fragments using a nanopore incorporating at least one metal ion as a sensing moiety.
Resumen de: US20260063642A1
0000 In an aspect, the present disclosure provides a method comprising: (a) obtaining a bodily sample from a subject; and (b) assaying the bodily sample to determine a level of analytes in the sample, wherein the analytes comprise nucleic acids, proteins, or metabolites.
Resumen de: CA2106077A1
2106077 9216902 PCTABS00016 A data processing pension plan monitor (40) is directed specifically to the management and controlled access of pensionbacked credit (AC). This system permits pension plan participants to establish a line of credit (LOC), based on their vested interest in a sponsored pension plan (10). This LOC is thereafter systematically applied to a plurality of account (80, 90), each permitted selected credit card (90) and/or check writing privileges. The charges associated with the credit accessed are paid back to the pensioner, thereby retaining certain tax deferred privileges while permitting access to the accumulated funds.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: CA2106077A1
2106077 9216902 PCTABS00016 A data processing pension plan monitor (40) is directed specifically to the management and controlled access of pensionbacked credit (AC). This system permits pension plan participants to establish a line of credit (LOC), based on their vested interest in a sponsored pension plan (10). This LOC is thereafter systematically applied to a plurality of account (80, 90), each permitted selected credit card (90) and/or check writing privileges. The charges associated with the credit accessed are paid back to the pensioner, thereby retaining certain tax deferred privileges while permitting access to the accumulated funds.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: EP4703717A1
The invention relates to a method for a preparation of a molecularly-imprinted-polymer (MIP) electrochemical sensor for an electrochemically inactive analyte detection, a method for using said sensor and such a sensor, where a redox-active surface of the sensor is preferably made of a transition metal oxide, and more preferably ruthenium oxide (RuO2), wherein the redox-active surface is coated by a MIP layer, wherein the MIP layer comprises a plurality of analyte-selective cavities. Said sensor is comprising at least one electrode with an electrically conductive surface with a redox-active surface, preferably a transition metal oxide, and more preferably ruthenium oxide.
Nº publicación: KR20260028678A 04/03/2026
Solicitante:
레이지바이오텍피티와이리미티드
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.