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BIOPRINTER

Resumen de: US20260307326A1

At a high level, disclosed herein is a bioprinter configured to fabricate a single but highly complex and multi-material regenerative scaffold compared to a more traditional approach of mass production of simple shapes. In an embodiment, printer may include a multi-head, multi-axial bio-printer for extrusion printing and laser manipulation of scaffold and/or organic materials specific to a particular tissue such as without limitation customized vascularized bone graft or joint replacement tissue. Printer may facilitate controlled deposition of cells, biologics, and/or scaffold and organic materials in controlled, mixed gradients.

COMPRESSION THERAPY ARRANGEMENT AND METHODS FOR OPERATING AND MONITORING THE SAME

Resumen de: US20260306304A1

The present invention relates to a compression therapy arrangement comprising a compression garment adapted to exert external pressure on a body portion, at least one sensor device associated with the compression garment and having at least one pressure sensor capable of producing at least one pressure signal indicative of the external pressure and transmitter means linked to the at least one sensor device and operable to transmit therapy signals corresponding to the pressure signals to an external device. The present invention also relates to methods for monitoring the compression therapy arrangement as well as a corresponding computer-readable medium and a corresponding computing system.

METHOD FOR MONITORING THE SPATIAL DEVIATION WITH RESPECT TO A PLANNED SURGICAL PROCEDURE

Resumen de: US20260306177A1

The present invention relates to a system comprising a processor, the system characterised by the processor having access to a planned surgical procedure comprising one or more three-dimensional (3D) images corresponding to one or more predefined states of the planned surgical procedure in a body portion, the processor is configured to execute instructions to perform the following steps of a method for monitoring the spatial deviation with respect to a planned surgical procedure: a) receiving one or more image of the body portion obtained by an intraoperative imaging device wherein the one or more image is associated to a certain predefined state of the planned surgical procedure; b) superimposing the one or more received images of step a) with the corresponding section of the one or more 3D image of the planned surgical procedure associated to the same predefined state; and c) determining the spatial deviation of the surgical procedure results with respect to the planned surgical procedure from the superimposition of the images of step b). The present invention also refers to a computer program and a method thereof.

Systems and Methods For Determining Neurological Condition Based On Surface Biopotentials

Resumen de: US20260306028A1

0000 Systems and methods for gesture control using biopotential sensing wearable devices are described. The system may include a processing pipeline configured to receive and process user biopotential data. The processing pipeline may be configured to generate, based at least in part on the processed user biopotential data, an assessment of the neurological condition of the user. The processing pipeline may include a machine learning model that has been trained and/or calibrated by one or more of the following: obtaining subject biopotential data collected from a plurality of subjects; obtaining subject neurological health data from the plurality of subjects (the subject neurological health data may relate to the neurological condition; labeling the subject biopotential data using the subject neurological health data to generate labeled subject data; and/or training the machine learning model using the labeled subject data.

INFORMATION PROCESSING SYSTEM, INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING PROGRAM, AND INFORMATION PROCESSING METHOD

Resumen de: US20260305934A1

An information processing apparatus that is communicably connected with another information processing apparatus, the information processing apparatus comprises: a processor configured to execute a program; and a storage device configured to store the program, the processor being configured to execute: acquisition processing of acquiring agreement information relating to the usage of subject eye image data of a patient by the other information processing apparatus; and transmission processing of transmitting the subject eye image data to the other information processing apparatus on the basis of the agreement information acquired by the acquisition processing.

METHOD FOR 3D PRINTING OF VASCULARIZED TISSUES AND ORGANS

Resumen de: US20260308499A1

0000 The 3D printing method disclosed here for the production of vascularized tissues and organs requires a droplet printer to produce photorealistic high-resolution prints and a device for applying non-directional or directional electromagnetic waves. The process uses a new type of capillary ink that crosslinks or undergoes a layer-forming reaction only in the edge area of the ink drops. Unbound capillary ink components are removed. The resulting cavities form a capillary network with diameters of up to approx. 10 μm. Also disclosed is a novel printer table for supplying the printed tissue with medium during printing and a printer head supply unit for individually mixing the bio-inks from cell concentrate and various ink concentrates.

COMPUTATIONAL METHODS FOR SELECTING PERSONALIZED NEOANTIGEN VACCINES

Resumen de: US20260311803A1

Systems and methods for identifying a personalized tumor vaccine are provided. Somatic variants for a subject are determined and RNA sequence reads from a tumor of the subject are obtained. From the RNA sequence reads, fusion proteins are determined, each fusion protein a fusion of a portion of a first protein and a portion of a second protein. Candidate neoantigens are selected, including a first subset of candidate neoantigens encoding somatic variants and a second subset of candidate neoantigens encoding residues of the portions of the first and second proteins. A score is determined for each candidate neoantigen using a scoring function including a first scoring term that upweights candidate neoantigens having a higher relative class I MHC affinity, given a class I HLA type of the subject. Two or more candidate neoantigens are selected for the tumor vaccine as a final set of neoantigens based on the respective scores.

CLASSIFICATION DISPLAY METHOD OF ULTRASOUND DATA AND ULTRASOUND IMAGING SYSTEM

Resumen de: US20260306061A1

Disclosed are a method for displaying ultrasonic data and an ultrasound imaging system. The method may include: acquiring ultrasonic video data to be displayed; obtaining at least one representative frame from the ultrasonic video data; classifying the representative frame to obtain a category of the representative frame, and determining a category of the ultrasonic video data according to the category of the representative frame; and displaying in categories the ultrasonic video data according to the category of the ultrasonic video data.

SYSTEMS AND METHODS FOR IMPROVING SLEEP DISORDERED BREATHING

Resumen de: US20260311867A1

0000 A neuromodulation system is provided herein. The system can include a neuromodulation device, an electronics package, which can be part of the neuromodulation device; an external controller; a sensor; and a computing device. The neuromodulation device can include a neuromodulation lead having a lead body configured to be bent to a desired shape and to maintain that shape in order to position the electrodes relative to neural and/or muscular structures when fully deployed. The neuromodulation device can also include an antenna including an upper and a lower coil electrically connected to each other in parallel. The computing device can execute a closed-loop algorithm based on physiological sensed data relating to sleep.

グローバル基準フレーム内の患者の歯列弓の解剖学的構造のモデルの位置を定義する技法

Resumen de: EP4814985A1

0001 A method for defining a position of an origin of a model of an anatomy of a patient's dental arch (302; 402) within a reference frame (XYZ) comprises receiving a first dataset comprising a surface representation of a surface topology of the patient's dental arch (302; 402) and segmentation lines representing borders between tooth crowns and adjacent soft tissue. A projection of the segmentation line into an occlusion plane (412) is generated. A center of a tooth in the occlusion plane (412) is determined as the centroid of an area bounded by a projected segmentation line. A segment of a parabola is fit to the centroids. An anterior point of the patient's dental arch (302; 402) is identified as the vertex of the parabola. A first translation vector is determined for positioning the anterior point at the origin of a third main component (X) of the reference frame.

SYSTEMS AND METHODS FOR MENTAL HEALTH ASSESSMENT

Resumen de: EP4819130A2

Disclosed is a method for identifying whether a subject is at risk of having a mental or physiological condition , comprising (a) obtaining data from said subject, said data comprising speech data and optionally associated visual data, (b) processing said data using a plurality of machine learning models comprising a natural language processing (NLP) model and an acoustic model to generate an NLP output and an acoustic output, wherein said plurality of machine learning models comprises a neural network trained on labeled speech data collected from one or more other subjects, wherein said labeled speech data for each of said one or more other subjects is labeled as (i) having, to some level, said mental or physiological condition or (ii) not having said mental or physiological condition; (c) fusing said NLP output and said acoustic output by (1) applying weights to said NLP output and said acoustic output to generate weighted outputs and (2) generating a composite output from said weighted outputs, wherein said NLP output and said acoustic output each comprise a plurality of outputs corresponding to a plurality of time segments of said speech data, and wherein said weights in (1) are temporally-based; and (d) outputting an electronic report identifying whether said subject is at risk of having said mental or physiological condition, based at least on said composite output, which risk is quantified in a form of a score having a confidence level provided in said report.

グローバル基準フレーム内の患者の歯列弓の解剖学的構造のモデルの配向を定義するための技法

Resumen de: EP4813350A1

0001 A method for defining an orientation of an origin of a model of an anatomy of a patient's dental arch (302; 402) within a global reference frame comprises receiving a dataset comprising a surface mesh, defined by a plurality of polygon, representing the surface of the dental arch (302; 402). For each polygon, a exterior normal vector is determined. A vector sum of exterior normal vectors defines a normal vector, and thereby an orientation, of an occlusion plane (412). A first rotation angle is determined for aligning the normal vector of the occlusion plane (412) with a first direction of the reference frame. An anterior side (504) of the dental arch (302; 402) is defined based on geometric properties of the surface mesh. A second rotation angle is determined for aligning an anterior-posterior direction of the dental arch (302; 402) with a second direction of the reference frame.

3D - AI System and Method for AI-based Automatic Laminate Veneer Design Using 3D Facial-Intraoral Registration

Resumen de: KR103029377B1

0001a 본 발명은 3D 안면-구강 정합 기반 AI 라미네이트 자동 설계 시스템 및 방법에 관한 것이다. 본 발명의 시스템은 3D 안면 스캔 데이터와 구강 내 스캔 데이터로부터 랜드마크를 추출하고 ICP 알고리즘으로 자동 정합하는 정합 모듈, 정합된 3D 모델로부터 안면 정중선, 치아 정중선, 스마일 라인, 구순 만곡, 동공간 거리, 치아 비율, 치은 노출량 및 입술-치아 관계를 포함하는 8개 이상의 심미 파라미터를 3D 공간 좌표계에서 자동 추출하는 파라미터 추출 모듈, 라미네이트 비니어 고유의 3중 제약조건인 0.3mm 내지 0.7mm 극박 두께 제약, 법랑질 보존 제약 및 대합치 간섭 회피 제약을 인공지능 모델 아키텍처에 내장하여 제약조건을 만족하는 라미네이트 비니어 메쉬만을 생성하는 AI 생성 모듈, 황금비율, RED 비율 및 환자 선호도를 포함하는 상충하는 복수의 심미 기준을 조율하여 복수의 파레토 최적 설계 후보를 제시하는 최적화 모듈, 및 블렌드셰이프 기반으로 미소, 대화, 입벌림을 포함하는 동적 표정 변화에 따른 라미네이트 비니어의 노출량 및 심미성을 실시간 시뮬레이션하는 시뮬레이션 모듈을 포함한다. 본 발명에 따르면, 종래의 2D 기반 수동 설계의 한계를 극복하고, 라미네이트 비니어에 특화된 End-to-End 자동 설계를 �

Device and method for determining joint angles of a subject

Resumen de: GB2705258A

A device and method for determining joint angles of a subject such as a human or animal, the device comprising: a digital camera which outputs video data comprising frames of 2D image data; at least one machine learning model; and a memory; wherein for each frame of image data at least one machine learning model determines a number of body landmarks each comprising 2D coordinate data; time-dependent analysis is performed S210 on the landmarks to estimate corresponding perpendicular third-dimension coordinates; the third dimension coordinates are used to convert S211 the 2D coordinate data into 3D coordinate data; and the 3D coordinate data is used to determine a 3D joint angle S212 of at least one joint of the subject and data representing the angle is output. Optionally, to perform the time-dependent analysis a Kalman filter, exponential smoothing or an auto regressive moving average is used. Fig. 5

LASER MARKABLE RESIN COMPOSITIONS FOR ORTHODONTIC APPLIANCES

Resumen de: WO2025117572A1

This disclosure provides laser markable polymerizable resin compositions comprising infrared absorbing marking additives to achieve improved laser markability of 3-D printed objects obtained from these polymerizable resin composition, and methods for marking the cured resin compositions using an infrared laser.

POLYETHER-CONTAINING POLYMERIZABLE COMPOUNDS AND USE IN CURABLE RESIN COMPOSITIONS

Resumen de: WO2025117528A1

This disclosure provides polymerizable resin compositions comprising a hydrophobic polyether-containing polymerizable polyurethane compound to impart improved stain resistance to polymeric materials formed from the polymerizable resin compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of dental devices, such as orthodontic appliances.

SCAFFOLDS BASED ON CONTINUOUS FOLDED SHEETS

Resumen de: WO2025117862A1

Provided herein are various embodiments related to the design, creation, and use of a folded sheet scaffold for medical devices. The scaffold comprises a shellular porous pseudorandom orientable architecture composed of a continuous folded sheet of topological genus-n. Methods for designing the scaffold involve driving noise from an infinite 3D noise field to define a field with real space, tuning field values based on user input, and subtracting to create thin wall geometry. The methods can be computer-implemented or executed by a processor following instructions stored on a non-transitory computer-readable medium. A computer system for designing the scaffold includes modules for noise-driving, tuning, and subtracting. The disclosure also includes a folded sheet scaffold formed by these methods and a medical device comprising the folded sheet scaffold.

REINFORCED MEDICAL IMPLANT AND METHOD OF USE

Resumen de: WO2025117414A1

A bio-compatible implant that is adapted for use in repairing soft tissue damage includes a fibrous scaffold having a length, a width and a thickness. The fibrous scaffold includes a plurality of fibers oriented in three orthogonal directions. In some instances, the three orthogonal directions align with the length, width and thickness of the fibrous scaffold. In some cases, two of the three orthogonal directions may be offset with respect to the length and width of the fibrous scaffold.

HELMET FOR NONINVASIVE BRAIN STIMULATION

Resumen de: WO2025111627A1

The invention relates to a helmet (1) for a noninvasive brain stimulation, comprising a stimulation unit (3) oriented towards a head-receiving area (2). In order to allow an individually determinable stimulation region to be precisely irradiated while nevertheless allowing the test person to have a certain degree of mobility, a suction opening (4) is proposed which is open towards the head-receiving area (1) and which is fluidically connected to a negative pressure connection (6) positioned outside of the head-receiving area (2).

BIOCOMPATIBLE GRANULE STRUCTURES

Resumen de: WO2025117313A1

The present disclosure provides biocompatible granule structures and associated assemblies and methods. These biocompatible granule structures are introduced into a void or space in a bone structure or between bone structures disposed on a flexible elongate structure to partially fill the volume and promote bony ingrowth and healing in a variety of surgical applications, such as kyphoplasty and vertebroplasty procedures and the like. The biocompatible granule structures are made of a bony substance or a biocompatible metallic, ceramic, or polymeric material and provide superior migration, interlocking behavior, and bony purchase and ingrowth properties.

3 APPARATUS FOR CREATING A 3D HUMAN BODY MODEL BASED ON BODY COMPOSITION AND METHOD OF OPERATION THEREOF

Resumen de: KR20260146556A

본 발명은 체성분 기반으로 3차원 인체 모델을 생성하고 생성된 3차원 인체 모델을 활용하는 기술에 관한 것이다. 본 발명의 일 측면에 따르면, 체성분 기반의 3차원 인체 모델 생성 장치가 수행하는 방법은, 신체 측정 정보 및 체성분 측정 정보를 포함하는 타겟 인체의 측정 데이터를 획득하는 단계; 및 미리 학습된 3차원 인체 모델 생성 모델을 이용하여, 타겟 인체의 측정 데이터로부터 타겟 인체의 3차원 인체 모델을 생성하는 단계;를 포함할 수 있다.

SYSTEMS AND METHODS FOR MIRRORING AN INTERFACE OF A MEDICAL DEVICE

Resumen de: EP4819155A1

0001 An example system includes an external device and a monitor-defibrillator. The monitor-defibrillator may include a detection circuit configured to detect an electrical signal indicative of an electrocardiogram (ECG) of a subject, a transceiver, a display and a processor configured to determine that the display is unable to visually present the ECG. In response to determining that the display is unable to visually present the ECG, the transceiver can transmit, to the external device, an instruction to display the ECG such that the ECG is mirrored via an external display of the external device.

Method and System for Fabricating Dental Prosthetics Based on Data-Driven Precision Color Measurement and Reproduction

Resumen de: KR20260145254A

0001a 데이터 기반 정밀 색상 측정 및 재현을 통한 치과 보철물 제작 방법이 개시되며, 상기 치과 보철물 제작 방법은, 환자의 자연 치아 색상을 측정하는 치아 색상 측정 단계; 측정된 색상 데이터를 처리 및 분석하여 환자의 자연 치아 색상을 재현할 수 있는 색상 또는 색상 조합을 추천하는 색상 데이터 처리 단계; 추천된 색상 또는 색상 조합을 기반으로 보철물을 설계하는 보철물 설계 단계; 및 추천된 색상을 기반으로 보철물을 성형하는 보철물 성형 단계를 포함하며, 상기 치아 색상 측정 단계는, 표준화된 프로토콜에 따른 측정 환경에서, 스펙트럼 카메라와 고분광 센서를 사용하여 치아의 색상을 측정하는 것을 포함한다.

ORAL DEVICE AND METHODS OF PRODUCING AND USING SAME

Resumen de: WO2025117762A1

An oral device configured for delivery of a liquid to the mouth of the subject is disclosed, along with kits and systems containing same, and methods of producing and using same. The oral device includes a base component comprising a reservoir that is configured for receiving a volume of liquid and contains a wicking agent disposed therein that dispenses liquid via capillary action. The base component also includes at least one opening formed therein for delivery of the liquid to the subject.

PAD-TYPE MOUTHPIECE CORRECTION DEVICE

Nº publicación: EP4817554A1 07/10/2026

Solicitante:

KIM HAN JOON [JP]
Kim, Han-Joon

Resumen de: EP4817554A1

A pad-type mouthpiece orthodontic device 10 according to the present invention includes: a horseshoe-shaped base portion 11 conforming to the shape of a dental arch; a pad pair portion for individually covering each tooth of the dental arch or collectively covering plural teeth of the dental arch; and a connection portion 13 that fixes the pad pair portion to the base portion. The base portion 11 is divided into a plurality of base segments based on desired unit regions, and the base segments each constitute an orthodontic block together with the connection portion and the pad pair portion. The base segment of the orthodontic block is configured to have elasticity or inelasticity specific to the block.