Alerta

HYBRID BIOELECTRONIC/ENGINEERED CELL IMPLANTABLE SYSTEM FOR THERAPEUTIC AGENTS DELIVERY AND APPLICATIONS THEREOF

Resumen de: US2025367371A1

A hybrid bioelectronic implantable device containing engineered cells for delivery of therapeutic agents to a subject to treat a medical condition of the subject. The device comprises an implantable device implantable inside the subject's body, wherein the implantable device comprises at least one cell housing containing the engineered cells; and an optical stimulating system within the at least one cell housing, wherein the optical stimulating system is configured to control production of at least one type of therapeutic agents by the engineered cells; wherein the medical condition of the subject comprises one of a sleep disorder, a circadian rhythm disorder, neuro disorders, infertilities, diabetes, obesity, eating disorders, cancers, bone marrow disorders, autoimmune disorders, addictive disorders.

NEW INSULIN FORMULATIONS FOR USE IN INSULIN PUMPS

Resumen de: WO2025245624A1

It is provided an insulin formulation comprising insulin and antimicrobial excipients for use in insulin pumps, connected to subcutaneous tissue via a catheter, a method also known as continuous subcutaneous insulin infusion, wherein the antimicrobial excipient inhibits growth of bacteria in insulin formulations and biofilm bacterial population formation on the internal surfaces of a catheter, allowing extending the time of use of the catheter.

PROGRAM, SYSTEM, INFORMATION PROCESSING DEVICE, SERVER, AND METHOD

Resumen de: WO2025249486A1

Provided are a program, a system, an information processing device, a server, and a method capable of executing a game in which a game effect occurs on the basis of continuously measured biological information. There is provided a program to be executed by a computer including a processor and a memory, the program causing the processor to execute a step of acquiring continuous blood glucose level data of a user associated with time information including an acquisition time prior to an acquisition time point, and a step of generating a predetermined game effect on the basis of the continuous blood glucose level data within a predetermined time period.

FOUR-COMPARTMENT DIFFUSION MODEL OF INSULIN IN HUMANS

Resumen de: US2025372257A1

Methods, systems, and apparatuses for modeling and determining of an insulin elimination rate in individuals are described. One or more physiological measurements associated with an individual may be determined and applied to a multi-compartment model. One or more physiological parameters, including an insulin elimination rate, may be determined based on applying the one or more physiological measurements to the multi-compartment model.

METHODS AND SYSTEMS FOR ENHANCING BLOOD GLUCOSE REGULATION AND TREATMENT OF DIABETES

Resumen de: US2025366743A1

Methods, systems, and devices for regulating blood glucose such as implantable encapsulated devices optionally with insulin and/or glucagon secreting cells in combination with glucose sensors and insulin infusion systems. For example, encapsulation devices may be connected to an insulin infusion pump for distribution of insulin. The insulin infusion pump may feature an insulin pouch fluidly connected to an insulin pump (or a syringe) and a glucose sensor separate from the encapsulation device. The system may feature an additional implantable device comprising insulin and glucagon secreting cells.

IMPLANTABLE SENSOR DEVICES, SYSTEMS, AND METHODS

Resumen de: US2025366749A1

Disclosed herein are devices, systems, and methods for a continuous analyte sensor, such as a continuous glucose sensor. In certain embodiments disclosed herein, various in vivo properties of the sensor's surroundings can be measured. In some embodiments, the measured properties can be used to identify a physiological response or condition in the body. This information can then be used by a patient, doctor, or system to respond appropriately to the identified condition.

A DEVICE FOR NON-INVASIVE ANALYTE MEASUREMENT

Resumen de: WO2025247647A1

The invention provides an apparatus for non-invasive in vivo measurement by Raman spectroscopy of analyte presence and/or concentration, such as glucose, in the skin of a subject, the apparatus comprising; a planar probe having one or more optical sources for irradiating a sample such as the skin of a subject; a spectrometer configured to receive Raman scattered radiation collected from the sample in response to the received radiation from the one or more optical sources; a numerical aperture controller to determine the numerical aperture of the apparatus, and thereby control the input light received by the spectrometer.

METHOD OF OUTPUTTNG BLOOD GLUCOSE DATA

Resumen de: US2025366742A1

One embodiment may provide a method of outputting blood glucose data including obtaining biometric information in response to an advertisement transmitted by a sensor transmitter, generating the biometric information as output, in the case that a communication failure occurs, indicating a data gap during a period of the communication failure, and if the communication failure is resolved, filling the data gap during a period from a time point when the communication failure is resolved to one advertisement which arrives after the communication failure is resolved.

METHOD OF PROVIDING NOTIFICATION OF SIGNAL LOSS IN GLUCOSE MONITORING SYSTEM

Resumen de: US2025366741A1

One embodiment may provide a method of providing a notification of signal loss in a glucose monitoring system, the method including, when a communication failure occurs between a terminal and a sensor transmitter, delaying a signal loss notification for a first period of time by the terminal, when the communication failure persists for the first period of time, further determining whether signal loss persists for a second period of time by the terminal, when the signal loss persists for the second period of time, generating the signal loss notification by the terminal, and outputting, by the terminal, the signal loss notification to a user.

AUTOMATIC DEVICE CONFIGURATION

Resumen de: US2025367380A1

Techniques for automatic device configuration are disclosed herein. In some embodiments, the techniques involve receiving patient data by one or more processors of a cloud-based server device. The techniques further involve obtaining, by the cloud-based server device, and based on the patient data, a value of a total daily dose of insulin for the specific patient. The techniques further involve automatically selecting, by the cloud-based server device, before the medical device has been set up to deliver insulin to the specific patient, a therapy configuration for the medical device. The techniques further involve determining, by the cloud-based server device, a set of therapy settings for the selected therapy configuration for the specific patient based upon the value of the total daily dose. The techniques further involve automatically configuring, via a non-medical device, the medical device with the set of therapy settings in a startup mode.

Systems and methods for monitoring and treating diabetic foot ulcers

Resumen de: AU2025267469A1

22222883_1 (GHMatters) P120626.AU.1 In some aspects, a system is provided for gathering and processing sensor data to identify a risk of impacting or causing a venous leg ulcer, wherein the system includes computer- readable memory and one or more processors and is configured to: obtain sensor feature data including a set of feature data representing output of a user sensor configured to be worn on a limb of a user; determine an activity classification using the set of feature data and an activity classification model, wherein the activity classification model includes a decision tree configured to assign the set of feature data to one of a plurality of different activity classifications wherein the different activity classifications comprises: i a first activity classification representing motion of the limb; ii a second activity classification representing no motion of the limb with static weight such as standing; and iii a third activity classification representing that the user is lying down; wherein the system is further configured to generate display data representing the activity classification; and transmit the display data to a computing device configured to present the display data. ov o v

INSULIN PATCH PUMP

Resumen de: US2025367370A1

A user-wearable patch pump system for delivery of insulin or other medicament can include a pump and an attachment portion that attaches the pump to a user's body. The pump can include a drive unit and a disposable cartridge containing a medicament with the drive unit configured to cause the pump to deliver the medicament in the cartridge to the user. The attachment portion can include a retention frame configured to selectively retain the pump therein and an adhesive patch configured to be attached to the user's body. The pump can be selectively attached to the retention frame and used to deliver medicament either through a cannula to an infusion site directly beneath the retention frame or through tubing to an infusion site displaced from the retention frame.

INSULIN MONITORING AND DELIVERY SYSTEM AND METHOD FOR CGM BASED FAULT DETECTION AND MITIGATION VIA METABOLIC STATE TRACKING

Resumen de: US2025367366A1

An insulin monitoring system includes one or more processors, one or more computer-readable storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include: first program instructions to track, in real time, the amount of insulin active in a patient; second program instructions to calculate the amount of insulin need of the patient by tracking the patient's metabolic states; third program instructions to compare the insulin active in the patient with the insulin need of the patient; and fourth program instructions to determine an insulin fault level based on the comparison.

A device for non-invasive analyte measurement

Resumen de: GB2641380A

An apparatus 2 for non-invasive in vivo measurement by Raman spectroscopy of analyte presence and/or concentration, such as glucose, in the skin of a subject is provided. The apparatus comprises a planar probe 8 having one or more optical sources (151, Fig. 1C) for irradiating a sample; a spectrometer 4 configured to receive Raman scattered radiation collected from the sample; a numerical aperture controller to determine the numerical aperture of the apparatus, and thereby control the input light received by the spectrometer. The numerical aperture controller may comprise an aperture stop (14, Fig 2A) within the spectrometer. The numerical aperture controller may be part of the probe for example a light absorbing region (25, Fig. 2C) around an opening in the PCB layer for receiving a Raman signal. Alternatively, the numerical aperture of an optical fibre interface (36, Fig. 5C) or buried light guide (54, Fig. 6B) may be selected; or the combination of a micro lens array (68, Fig. 7A) and pinhole array (64, Fig. 7B) in the probe may be selected to determine the numerical aperture.

METHOD OF PROVIDING NOTIFICATION OF SIGNAL LOSS IN GLUCOSE MONITORING SYSTEM

Resumen de: EP4656125A1

One embodiment may provide a method of providing a notification of signal loss in a glucose monitoring system, the method including, when a communication failure occurs between a terminal and a sensor transmitter, delaying a signal loss notification for a first period of time by the terminal, when the communication failure persists for the first period of time, further determining whether signal loss persists for a second period of time by the terminal, when the signal loss persists for the second period of time, generating the signal loss notification by the terminal, and outputting, by the terminal, the signal loss notification to a user.

METHOD OF OUTPUTTNG BLOOD GLUCOSE DATA

Resumen de: EP4657457A1

One embodiment may provide a method of outputting blood glucose data including obtaining biometric information in response to an advertisement transmitted by a sensor transmitter, generating the biometric information as output, in the case that a communication failure occurs, indicating a data gap during a period of the communication failure, and if the communication failure is resolved, filling the data gap during a period from a time point when the communication failure is resolved to one advertisement which arrives after the communication failure is resolved.

TECHNIQUES AND DEVICES PROVIDING ADAPTIVITY AND PERSONALIZATION IN DIABETES TREATMENT

Resumen de: EP4657456A2

Disclosed are a device, system, methods and computer-readable medium products that provide an updated insulin-to-carbohydrate ratio and an updated total daily insulin. The described processes may be used for periodic updating of the insulin-to-carbohydrate ratio and the total daily insulin. The insulin-to-carbohydrate ratio and/or the total may be used in the calculation of new doses of insulin that a drug delivery device may be commanded to deliver to a user.

BODY ATTACHMENT UNIT FOR CONTINUOUS GLUCOSE MONITORING

Resumen de: EP4656133A2

The present invention relates to a body attachment unit for continuous glucose monitoring. The present invention provides a body attachment unit for continuous glucose monitoring, wherein: the body attachment unit is manufactured in the state in which the body attachment unit is assembled in an applicator, and thus separate additional work is minimized and the body attachment unit can be attached to the body by simply operating the applicator; in particular, a wireless communication chip is disposed in the body attachment unit so as to communicate with an external terminal, and thus simple and convenient use can be achieved without any additional work for connection of a separate transmitter and maintenance and management can also be easily performed; and the monitoring operation is started by a user's manipulation after the body attachment unit is attached to the body, and thus the user can adjust the operation start time to an appropriate point as necessary and the operation can be started in a stabilized state so as to enable more accurate glucose monitoring.

CONTINUOUS BLOOD GLUCOSE MEASUREMENT APPARATUS

Resumen de: EP4656127A2

The present invention relates to a continuous blood glucose measurement apparatus which, by manufacturing a body-attachable unit in an assembled state inside an applicator, minimizes the additional work by a user for attaching the body-attachable unit to the body and thus enables the body-attachable unit to be attached to the body simply by means of operating the applicator, and, by providing a wireless communication chip on the body-attachable unit and enabling communication with an external terminal, can be used in a simple and convenient manner without the additional work of connecting a separate transmitter and enables easier maintenance and management, and, by having the operation of the body-attachable unit initiated by means of the user's manipulation after being attached to the body, enables the operation initiation point to be adjusted to an appropriate point as necessary by the user, enables an operation initiation in a stabilized state and thus enables more accurate blood glucose measurement.

Continuous glucose measurement apparatus

Resumen de: NZ803295A

Prior art glucose measurement devices have issues relating to poor user experiences where manual multiple steps are required to obtain readings. Herein described is a glucose measurement apparatus, comprising a plunger body (300) disposed inside the main case and configured to move the body attachable unit from a first location to a second location, a needle unit (550) separably coupled to the body attachable unit, a return prevention unit (340, 161) configured to block returning movement of the plunger body to the first position after the plunger body is moved to the second position is included in the main case, and the needle unit (550) is configured to move together with the body attachable unitas the body attachable unit being moved from the first location to the second location, and is configured to move toward the first location after the body attachable unit is inserted into the body.

BLOOD GLUCOSE ESTIMATION USING NEAR INFRARED LIGHT EMITTING DIODES

Resumen de: US2025359762A1

Near Infrared Spectroscopy is employed to non-invasively detect blood glucose concentrations, in a multi-sensing detection device. A multi-layered artificial neural network is used to assess these relationships of non-linear interference from human tissue, as well as differences among individuals, and accurately estimate blood glucose levels. Diffuse reflectance spectrum from the palm at six different wavelengths analyzed with a neural network, results in a correlation coefficient as high as 0.9216 when compared to a standard electrochemical glucose analysis test.

BIOMETRIC SENSORS FOR ENHANCED DETECTION, STIMULATION, AND NOTIFICATION

Resumen de: US2025359828A1

The technologies discussed herein relate to a biometrics system comprising one or more processors, computer storage memory having computer-executable instructions, surgically implantable devices, and wearables (e.g., an apparel item configured for an upper torso, an apparel item configured for a lower torso, a sock, a headband, other types of wearables, or one or more combinations thereof) having one or more biometric sensors (e.g., a heart rate sensor, a sweat sensor, a glucose sensor, other types of biometric sensors, or one or more combinations thereof) and one or more sensation devices (e.g., a plurality of visible light sources, a haptic feedback device, other types of sensation devices, or one or more combinations thereof). The wearables may also include one or more environmental sensors. The wearables emulate, transmogrify, or enhance one or more human senses using the one or more sensation devices based on biometric data or environmental data received.

METHODS, SYSTEMS, AND DEVICES FOR CALIBRATION AND OPTIMIZATION OF GLUCOSE SENSORS AND SENSOR OUTPUT

Resumen de: US2025359790A1

A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free, or near calibration-free, sensor.

NON-INVASIVE GLUCOSE MEASUREMENT DEVICE AND METHOD

Resumen de: WO2025244151A1

The present invention relates to a non-invasive glucose measurement device and method. To this end, the non-invasive glucose measurement device according to one embodiment of the present invention may comprise: a light irradiation unit which is positioned beneath an inner lower case disposed beneath an inserted finger, and which includes a first light-emitting element and a second light-emitting element for irradiating light toward the finger placed on the inner lower case; a light reception unit which is disposed on an inner upper case disposed on the finger, and which includes a first light-receiving element and a second light-receiving element for receiving the light irradiated from the light irradiation unit and transmitted through the finger; a motor unit including a first motor disposed at one side of the inner lower case and a second motor disposed at the other side of the inner lower case; a pressure sensor unit which is disposed beneath the inner lower case, and which includes a first pressure sensor and a second pressure sensor for measuring pressure applied by the finger; and a processor for measuring glucose by using the amount of light received through the light reception unit.

CATHETER INSERTION DEVICE AND METHOD OF INSERTING A CATHETER

Nº publicación: US2025360273A1 27/11/2025

Solicitante:

BECTON DICKINSON AND COMPANY [US]
Becton, Dickinson and Company

Resumen de: US2025360273A1

An insulin infusion system is provided with a manual insertion device having a dual retraction spring (230) configuration for automatic introducer needle (222) retraction. A button (200) of the insertion device is used to insert the introducer needle (222) and catheter (202), and once the introducer needle (222) and catheter (202) have been fully inserted, a rotating engagement releases the dual retraction springs (230) such that the introducer needle (222) automatically retracts, leaving the catheter (202) in the body of the user. An end of the introducer needle (222) remains in the inserted catheter (202) and/or in the septum (206) of the inserted catheter (202) to provide an uninterrupted fluid path.