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325
resultados
Última actualización
11/09/2026 [07:55:00]
Resultados 25 a 50 de 325
Resumen de: WO2025090763A1
Methods, kits and compositions of detecting analytes, typically analytes relevant to neurodegenerative diseases such as neurofilament light chain, in a sample are described herein using chemiluminescent labels. Solid supports, reagents, and compounds for use in these methods are also described. Typically, the methods involve specific assay formats which provide the requisite high resolution for detecting low concentrations of analytes in samples and may be used in positions of the healthcare ecosystem close to the patient. These methods, systems, and apparatuses may afford early detection and prognosis of a wide variety of neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis.
Resumen de: WO2025026904A1
The present invention relates to a microscopy method for obtaining a high-resolution image of a biological sample comprising a substance to be analyzed, wherein an image sequence is obtained by expansion microscopy comprising the steps: g. providing a biological sample, h. mixing said biological sample with a swellable material and forming bonds, preferably covalent bonds, between said substance to be analyzed and the swellable material, thereby forming a mixture, i. fragmenting said substance to be analyzed, j- expanding the mixture comprising said swellable material and said fragmented substance to be analyzed, k. staining the sample either before or after steps (a), (b), (c), or (d) and imaging the obtained mixture under an optical microscope equipped with a camera or a resonant scanner. It also refers to compounds and stabilization chambers for use in such a method.
Resumen de: MX2026001711A
The invention provides novel anti-IL-5 proteins, antibodies and IL-5 binding fragments thereof, which inhibit association of IL-5 with IL-5 receptor and are suitable for administration to a human or feline subject. The invention provides novel compositions and methods of treating, alleviating the symptoms of, or preventing, lung diseases, cardiovascular diseases, cancers, metabolic diseases, neurological diseases, and infectious diseases, comprising administering an effective amount of an anti-IL-5 protein, antibody, or fragment thereof. The methods and compositions are used to treat or prevent IL-5-related disorders.
Resumen de: AU2024293997A1
A machine learning model can be trained to predict brain tau or amyloid β status of a patient using, at least in part, biomarker data of the patient. The brain tau or amyloid β status can include one or more continuous-valued brain tau or amyloid β levels and/or concern brain tau or amyloid β levels in multiple regions of the brain of the patient. A prediction of brain tau or amyloid β status of the patient can be generated by applying the subject data of the patient to the machine learning model. The operations can further include providing the prediction of brain tau or amyloid β status of the patient. The machine learning model be used in selection of patients for treatment with an anti-tau therapy and/or an anti-amyloid therapy, in treatment of patients having or suspected of having Alzheimer's Disease (AD), or in monitoring of AD treatment efficacy.
Resumen de: SA520420801B1
Provided a re antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same. Fig 1.
Resumen de: CN122341632A
The present invention provides material compositions and/or methods useful for the prevention and/or treatment of protein depletion (proteopenia), comprising material compositions that retain the natural function of peptides/proteins while limiting and/or preventing amyloid formation and/or aggregation of the peptides/proteins. Also provided are material compositions and formulations for enhancing peptide/protein solubility, stability, cycle time, receptor interaction, brain permeability, CSF half-life, promoting peptide/protein synthesis and purification.
Resumen de: WO2025137532A1
Disclosed herein are methods of measuring amyloid β protofibril levels in biological samples. Methods disclosed herein may detect amyloid β protofibril at femtomolar concentrations and selectively measure protofibril as compared to amyloid β monomers.
Resumen de: US20260251568A1
Disclosed herein is a device for chiral sensing comprising a chiral plasmonic substrate, wherein when the device is assembled together with a first light source, a liquid sample comprising a plurality of chiral analytes, a second light source, and an instrument, the first light source is configured to illuminate the chiral plasmonic substrate with electromagnetic radiation; and the second light source is configured to illuminate the chiral plasmonic substrate with circularly polarized electromagnetic radiation. The instrument is configured to process electromagnetic signal from the first light source and the second light source to determine a property of the liquid sample.
Resumen de: WO2026176371A1
The present disclosure is related to drug delivery compositions containing extracellular vesicles having a therapeutic by utilizing visceral sensory neurons, a method using thereof for delivering the drugs to central nervous system and an organoid on chip model comprising a three-compartment axis-on-a chip for testing delivery of the drug containing EV over BBB, wherein the compositions comprising bacterial extracellular vesicles (EV) and therapeutics, wherein the drug or the therapeutic is encapsulated within the EV or attached or conjugated to EV.
Resumen de: US20260251664A1
0000 The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the evaluation of risk of dementia in a middle-aged individual within a specified timeframe, for example 5, 10, 15 and/or 20 years. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to evaluate risk of dementia within 5, 10, 15 and/or 20 years. In another aspect, methods are provided for evaluating risk of dementia within 5, 10, 15 and/or 20 years in a middle-aged individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 6.
Resumen de: US20260251660A1
The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.
Resumen de: AU2025374616A1
Methods of detecting analytes in a sample are described herein using chemiluminescent labels and branched DNA. Solid supports, reagents, and compounds for use in these methods are also described. Typically, the methods involve specific assay formats which provide the requisite high resolution for detecting low concentrations of analytes such as exosome protein biomarkers in samples.
Resumen de: US20260251557A1
0000 A method includes contacting one or more volatile organic compounds (“VOCs”) evolved from a sample to one or more detection regions configured for sensitivity against one or more VOCs. The contacting causes a change to the detection regions that is visible to the human eye. The method also includes determining the presence or absence of a VOC by comparing the change to the detection regions to a key, with the key being a visible change. A system utilizing the method is also described.
Resumen de: WO2026178110A1
Disclosed is a method for the treatment of major depressive disorder (MDD), which includes administering to a human subject suffering from MDD, a therapeutically effective amount of an antibody selected from fezakinumab, ustekinumab, gusacitinib and dupilumab, and combinations thereof.
Resumen de: WO2026177204A1
The purpose of the present invention is to provide a novel naturally derived cellular vesicle staining agent that can easily fluorescently stain cellular vesicles and that is safe even when introduced into the body, and to provide a cellular vesicle staining agent having anti-inflammatory activity. The purpose of the present invention is also to provide a method for producing a cellular vesicle staining agent, whereby the cellular vesicle staining agent can be easily produced. Another purpose of the present invention is to provide a method for detecting cellular vesicles using the cellular vesicle staining agent. The present invention provides: a cellular vesicle staining agent comprising chlorophyll or a chlorophyll derivative; an anti-inflammatory agent comprising chlorophyll or a chlorophyll derivative as an active ingredient; a method for producing a cellular vesicle staining agent, the method comprising a step for extracting a cellular vesicle staining agent from a photosynthetic organism; and a method for detecting a cellular vesicle in a sample or in a body using the cellular vesicle staining agent.
Resumen de: WO2026175415A1
Disclosed is a preparation technical method capable of preparing a large number of pathogenic tau proteins having a pathological conformation similar to that in the brain of a patient with neurodegenerative diseases by means of in vitro preparation and continuous multi-round amplification. The method can achieve continuous multi-round amplification of a patient brain-derived pathological tau protein by using only a small amount of the patient brain-derived pathological protein as a template, a recombinant human-derived tau protein monomer, and a negatively charged polyanion compound as an inducing cofactor, thereby achieving the in vitro preparation of a large amount of the pathological tau protein. In addition, the pathological tau protein prepared by the method can maintain the special pathological conformation of the original tau protein of the disease, has the same pathological activity as the original tau protein, and can be used for probe screening, antibody preparation, and verification model development.
Resumen de: WO2026176083A1
The present invention relates to a method for diagnosing a patient having a neurological (including neuromuscular) disorder, such as ALS. The invention further relates to a method for distinguishing between neurological disorders, said method extending to include the ability to discriminate one subtype from other subtypes of the same disorder.
Resumen de: WO2026178077A1
The present disclosure relates to methods and compositions for editing an AMPK polynucleotide encoding an AMPK protein. The disclosure also relates to methods and compositions for modulating activity of an AMPK protein, for promoting activation of an AMPK protein, for repairing function of a pathogenic AMPK protein, and methods for regulating energy homeostasis and/or for treating or preventing an AMPK-associated disease or condition in a subject.
Resumen de: WO2026178362A1
Described herein are polypeptide useful for identifying compound for modulating aberrant protein condensates. The polypeptide comprise a condensate-modulating protein, a first biomarker polypeptide, a barcoding biomarker polypeptide. When inside a cell, the non-natural polypeptide exist as multiple fragments, including a first fragment comprising the condensate-modulating protein and the first biomarker polypeptide, and a second fragment comprising the barcoding biomarker polypeptide. The barcoding biomarker polypeptide is uniquely associated with and identifies the cell expressing associated condensate-modulating protein. Also described is a polynucleotide encoding the non-natural polypeptide, a library of the polynucleotide, and a method of identifying compound for modulating aberrant protein condensates using the non-natural polypeptide, the construct, and/or the library.
Resumen de: US20260250375A1
0000 The disclosure relates to compounds specific for IL23A and TNF-alpha, compositions comprising the compounds, and methods of use thereof. Nucleic acids, cells, and methods of production related to the compounds and compositions are also disclosed.
Resumen de: US20260251541A1
0000 The present invention relates to a method of fixing extracellular vesicles. The method includes providing a sample containing extracellular vesicles and contacting the sample with a non-reversible cross-linking agent and, optionally, an aldehyde-containing fixative. Preferably the non-reversible cross-linking agent is 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide. The method also includes imaging the fixed extracellular vesicles for the determination or exclusion of disease or disorder in a clinical sample. The present invention also relates to a kit for fixing extracellular vesicles in a biological sample.
Resumen de: US20260251665A1
0000 A method of aiding diagnosis of a disease or condition in a subject, wherein the method comprises comparing a level of at least one natriuretic peptide detected in a biological sample obtained from the subject with a reference level of the at least one natriuretic peptide, wherein the biological sample is an oral mucosal transudate (OMT) sample obtained from one or more mucous membranes inside the mouth of the subject.
Resumen de: US20260248877A1
0000 The present invention provides inhibitory peptides for use in the diagnostic and/or treatment of tauopathies, in particular Alzheimer's Disease and Pick's Disease. The inhibitory peptides comprise a hexapeptide sequence that specifically inhibits interactions of the PHF6 sequence within pathological Tau protein.
Resumen de: US20260250647A1
0000 The present disclosure relates to a chimeric protein molecule comprising a degradation domain including an E3 ubiquitin ligase motif without lysine residues and a targeting domain comprising a substrate-binding motif which is heterologous to the E3 ubiquitin ligase motif. A linker couples the degradation domain to the targeting domain. Also disclosed are compositions as well as methods of treating a disease, substrate silencing, forming a ribonucleoprotein, screening agents for therapeutic efficacy against a disease, and methods of screening for disease biomarkers, as well as mRNA molecules, vectors, and encapsulated nucleic acid molecules encoding chimeric protein molecules.
Nº publicación: US20260251650A1 27/08/2026
Solicitante:
NEURO BIO LTD [GB]
Neuro-Bio Ltd
Resumen de: US20260251650A1
0000 The invention relates to neurodegenerative disorders, and the diagnosis and/or prognosis of neurodegenerative disorders in a test subject using a lateral flow test, or the like. The invention also relates to detecting diagnostic and prognostic biomarkers in a range of various patient sample types for diagnosing and/or prognosing neurodegenerative disorders, such as Alzheimer's disease. The invention further provides biomarker detection methods, and apparatus and apparatuses for diagnosing and prognosing neurodegenerative disorders, and methods of treating patients diagnosed or prognosed with a neurodegenerative disorder. The invention also extends to detection of biomarkers and/or screening in pre-symptomatic subjects, for early diagnosis, to enable disease prevention or intervention.
BOPI
Sede Electrónica
