Alerta

COMPOSITIONS AND METHODS FOR TREATING CEREBRAL VASOSPASM

Resumen de: US20260266819A1

The present invention relates to the field of inflammation. More specifically, the present invention provides compositions and methods for treating cerebral inflammation and associated sequelae thereof including cerebral vasospasm. In one embodiment, a method for treating cerebral vasospasm in a patient comprises the step of administering to the patient a PD-1 agonist, wherein a blood sample obtained from the patient comprises elevated PD-1 expression on monocytes relative to a control.

MODULAR PLATFORM FOR MEASURING VOLATILE ORGANIC COMPOUND PROFILES FROM EXHALED BREATH AND CORRELATING THOSE PROFILES TO PHYSIOLOGICAL AND PATHOLOGICAL STATES

Resumen de: US20260269021A1

A modular breath analysis system is disclosed for analyzing volatile organic compounds in exhaled breath and correlating measured compound profiles with physiological or pathological states of a subject. The system may include a breath sampling subsystem, a breath conditioning subsystem, a sensor array, and a processing subsystem configured to generate a volatile organic compound profile and apply a correlation model. In some embodiments, a base instrument is configured to receive interchangeable sensing modules through mechanical, fluidic, and electrical interfaces. The sensing modules may include gas sensors, flow-routing structures, filters, membranes, identifiers, calibration data, or combinations thereof. Different sensing modules may be configured for different volatile organic compound panels associated with metabolic conditions, blood glucose estimation, respiratory conditions, infectious diseases, cancer, or other physiological or pathological states.

BIOHYBRID ROBOT INCLUDING EYE/BRAIN ORGANOID, MOTOR NERVE SPHEROID, AND MUSCLE BUNDLE, AND MANUFACTURING METHOD THEREFOR

Resumen de: EP4803610A1

The present invention relates to a biohybrid robot comprising an eye/brain organoid, a motor neuron spheroid and a muscle bundle, and a method for fabricating the same, and a versatile biohybrid robot according to the present invention may cause movement of muscle cells by an electrophysiological signal generated from the eye/brain organoid like a human motor system using light stimulation and a neurotransmitter. It is expected to be utilized in disease models that stimulate human signal transduction systems by combining various neurodegenerative disease models, such as Parkinson's and Alzheimer's disease models, with eye tumor models in the future, and be utilized in the fabrication of drug screening platforms using the operation of versatile biohybrid robots composed of biological tissues.

NOVEL DIAGNOSTIC METHOD

Resumen de: WO2025093893A1

The present invention relates to methods of measuring the presence and/or levels of a combination of five biomarkers in a sample, said biomarkers being neurofilament light (NfL) polypeptide, glial fibrillary acidic protein (GFAP), β-Amyloid 1-42 (Aβ1-42), β-Amyloid 1-40 (Aβ1-40), and phosphorylated Tau (p-Tau181, pTau-231 and/or p-Tau217). The methods can be used to predict the subject's risk or likelihood of having and/or developing Alzheimer's disease, thus also provided is a method of predicting a subject's risk or likelihood of having and/or developing Alzheimer's disease, said method comprising measuring the presence of and/or the levels of the combination of five biomarkers. Further provided is a method of prognosing or diagnosing Alzheimer's disease in a subject comprising the methods of measuring the presence of and/or the levels of the combination of five biomarkers, and a method of treating Alzheimer's disease comprising predicting a subject's risk or likelihood of developing or having Alzheimer's disease using the methods of measuring the presence and/or levels of the combination of five biomarkers and administering a treatment if the risk or likelihood exceeds a threshold value.

中枢神経系の抗炎症剤、神経炎症を伴う中枢神経系疾患の治療剤及び神経炎症を伴う中枢神経系疾患の治療剤のスクリーニング方法

Resumen de: JP2026144588A

【課題】中枢神経系の抗炎症剤、神経炎症を伴う中枢神経系疾患の治療剤及び神経炎症を伴う中枢神経系疾患の治療剤のスクリーニング方法の提供。【解決手段】セラミドキナーゼの機能を阻害する化合物を有効成分として含む、中枢神経系の抗炎症剤又は神経炎症を伴う中枢神経系疾患の治療剤であって、前記化合物は、セラミドキナーゼ遺伝子の発現を抑制する又はセラミドキナーゼタンパク質の活性を阻害する化合物である抗炎症剤。【選択図】なし

NAIL-BASED NGS DATA ANALYSIS METHOD AND SYSTEM FOR DISEASE PREDICTION

Resumen de: EP4804206A1

The present invention relates to a next generation sequencing (NGS) method for disease prediction through analysis of nail-derived germline mutations and somatic mutations, and a system therefor. Specifically, the present invention relates to a nail-based NGS analysis method for predicting or diagnosing a disease, comprising the steps of: isolating gDNA from nails; and analyzing the isolated gDNA using NGS.

用于阿尔茨海默病早期诊断的荧光免疫层析检测试剂盒

Resumen de: CN122709740A

本发明公开了一种用于阿尔茨海默病早期诊断的荧光免疫层析检测试剂盒，尤其涉及基于AI预测构象表位的纳米抗体、CRISPR‑Cas12a信号放大系统和纳米抗体阵列联合检测的试剂盒及其制备方法。本试剂盒具有AI预测构象表位的纳米抗体、CRISPR‑Cas12a信号放大系统、纳米抗体阵列多指标联合检测及智能解读系统，通过一次加样、一次层析，即可同时获得多个指标的准确信息，简化了检测流程，实现AD相关蛋白的超灵敏检测、特异性识别和疾病分期诊断。

识别临床试验中纳入和/或排除的受试者的方法

Resumen de: WO2025042969A2

Disclosed herein are methods of selecting a candidate subject based on predicted response to an experimental treatment or therapeutic agent, and related methods of identifying subjects eligible to participate in a clinical trial that may be likely to respond to placebo. The methods disclosed herein are useful in the identification and/or selection of subjects for inclusion or exclusion from the clinical trial.

抗eMTBR-tau243片段V256剪切位点的单克隆抗体及其应用和产品

Resumen de: CN122705733A

0001 本发明提供了一种抗eMTBR‑tau243片段V256剪切位点的单克隆抗体及其应用和产品，涉及生物技术领域。本发明提供的单克隆抗体的可变区包括：氨基酸序列如SEQ ID NO.1所示的互补决定区CDR1‑VH、氨基酸序列如SEQ ID NO.2所示的互补决定区CDR2‑VH、氨基酸序列如SEQ ID NO.3所示的互补决定区CDR3‑VH、氨基酸序列如SEQ ID NO.4所示的互补决定区CDR1‑VL、氨基酸序列如SEQ ID NO.5所示的互补决定区CDR2‑VL和氨基酸序列如SEQ ID NO.6所示的互补决定区CDR3‑VL，能特异性识别eMTBR‑tau243片段V256剪切位点。

イヌの障害の低侵襲診断方法

Resumen de: WO2025049924A1

The present disclosure relates to a method for detecting or measuring the content of one or more selected biomarkers in a canine skin sample, comprising the steps of: a) applying an adhesive tape to an exposed skin target area of the canine, whereby an epidermal sample adhering to the adhesive tape is collected, and b) detecting the presence of, and/or measuring the content of, the one or more selected biomarkers in the epidermal sample obtained at step a). It further relates to method of determining the presence of a cutaneous disorder state in a canine skin, a method for the diagnosis of an atopic dermatitis state in a canine skin, a method of determining the beneficial effect of a pharmaceutical agent and/or a selected diet regimen in a canine affected with an atopic dermatitis and a kit of parts for detecting and/or measuring canine biomarkers in a canine epidermal sample.

用于确定血浆激肽释放酶系统生物标记的试验

Resumen de: WO2015061183A1

Methods and assays for determining the activation level of the plasma kallikrein (pKal) system and the uses thereof for assessing the activity of pKal modulators on the pKal system.

一组特异性结合并检测大鼠IL-1R1的单克隆抗体及检测试剂盒

Resumen de: CN122705737A

0001 本发明提供了一组特异性结合并检测大鼠IL‑1R1的单克隆抗体及检测试剂盒，属于免疫学检测技术领域。本发明提供了一组可特异性结合并检测大鼠白介素1受体1型蛋白（IL‑1R1）的单克隆抗体，所述单克隆抗体以大鼠来源IL‑1R1（rat IL‑1R1）为抗原通过免疫后得到，尤其是单克隆抗体MM08H和MM10H均与rat IL‑1R1结合良好，经配对检测发现，鼠单克隆抗体MM10H可作为包被抗体，通过显色催化酶标记的单克隆抗体MM08H可作为检测抗体，可将所述单克隆抗体用于rat IL‑1R1的免疫学检测。本发明利用所述单克隆抗体构建了rat IL‑1R1的免疫学检测试剂盒，具有良好的检测重复性和稳定性；最低检测限为4.33pg/ml，检测灵敏度良好。

一种TILRR-HDAC6蛋白复合体、TILRR源性的HDAC6抑制剂及其应用

Resumen de: CN122705757A

0001 本发明公开了一种TILRR‑HDAC6蛋白复合体、TILRR源性的HDAC6抑制剂及其应用。所述TILRR‑HDAC6蛋白复合体包括TILRR蛋白和HDAC6蛋白，所述TILRR蛋白特异性结合于HDAC6蛋白的去乙酰化结构域；所述TILRR蛋白的氨基酸序列如SEQ ID NO:1‑ SEQ ID NO:3所示，所述HDAC6蛋白的氨基酸序列如SEQ ID NO:4所示。本发明首次发现TILRR蛋白与HDAC6蛋白存在特异性相互作用，二者形成稳定的复合体，且TILRR特异性结合于HDAC6的去乙酰化结构域。本发明为HDAC6相关疾病的治疗提供了全新的靶点和候选药物分子，具有重要的科学意义。

一种抗人Aβ的抗体及其应用

Resumen de: CN122705731A

0001 本发明公开了一种抗人Aβ的抗体及其应用。所述抗体含重链可变区VH和轻链可变区VL；所述VH包含HCDR1、HCDR2和HCDR3，所述VL包含LCDR1、LCDR2和LCDR3；所述HCDR1‑HCDR3分别包含如SEQ ID NO:1‑3所示的氨基酸序列，所述LCDR1‑LCDR3分别包含如SEQ ID NO:4‑6所示的氨基酸序列。本发明的抗体灵敏性高、特异性好，基于该抗体对人Aβ进行免疫检测，操作简单、灵敏度高、特异性强，可实现人Aβ的快速检测，对评估人Aβ具有重要意义。

GFAP的ELISA检测试剂盒

Resumen de: CN122705729A

0001 本发明公开了一种GFAP的ELISA检测试剂盒，属于生物医药检测技术领域。本发明提供了一对特异性结合GFAP的兔源单克隆抗体对，其中第一抗体的轻链氨基酸序列如SEQ ID NO:1所示、重链氨基酸序列如SEQ ID NO:2所示，第二抗体的轻链氨基酸序列如SEQ ID NO:3所示、重链氨基酸序列如SEQ ID NO:4所示；所述第一抗体与第二抗体识别GFAP上不同的抗原表位，能够形成双抗体夹心复合物。本发明还提供了包含所述抗体对的ELISA试剂盒、非诊断目的的GFAP检测方法及所述试剂盒在制备检测GFAP试剂中的应用。本发明试剂盒的检测线性范围为1.56～600pg/mL，检测下限为1.56pg/mL，具有灵敏度高、特异性强、重复性好的优点，适用于GFAP相关疾病的早期辅助诊断和科研定量分析。

세포의 특성 신호를 이용하여 살아있는 인간 또는 동물 세포를 자극하는 방법 및 관련 장치

Resumen de: WO2025153985A1

This disclosure relates to analysis of biological patterns and more in detail a method of generating a characteristic signal of a living human or animal cell and a related device for implementing it, as well as a method of stimulating a living human or animal cell either in vivo or in vitro and a related appliance.

B-异噁唑衍生物、诊断组合物及其相关方法

Resumen de: AU2024401251A1

The present application relates to novel b-isox analogs for use in detecting misfolded proteins associated with neurodegenerative diseases, such as ALS, PD, AD, FTLD, and LATE. The present inventors identified and modified a specific site on the b-isox molecule, which significantly enhances detection capabilities. This modification also allows for the selection of analogs that either exhibit low background interference or alter cellular targets, based on the alteration of a functional group at critical site.

用于分类、检测和治疗生物学疾病的方法

Resumen de: WO2025129037A1

The current disclosure provides for methods and compositions for classifying subjects having different biological states. The disclosure describes a method comprising: filtering sequence data obtained from a sample from a subject based on long non-coding RNA (lncRNA) and/or pseudogene RNA (pgRNA), and/or the reference genome; determining a biological state classification of the subject by providing the filtered sequence data to one or more machine learning classifiers as input, wherein the one or more machine learning classifiers is trained to output biological state classifications based on filtered sequence data of a training data set.

中枢神経系疾患を治療するための抗－ＦＡＭ１９Ａ１拮抗剤の用途

Resumen de: WO2021176336A1

The present disclosure relates to a method of treating a disease or disorder associated with an abnormality in CNS function. Also provided is a method for diagnosing and/or identifying a subject having an abnormality in CNS function. FAM19A1 antagonists that can be used with the present disclosures are also provided.

アロジェニック間葉系幹細胞によるアルツハイマー病の治療

Resumen de: AU2021340971A1

Compositions and methods are disclosed herein for the treatment of Alzheimer's disease with allogeneic mesenchymal stem cells. The methods of treatment involve the administration of a composition of allogeneic mesenchymal stem cells to a subject in need thereof, wherein the effectiveness of the treatment methods can be determined through the measurement of specific biomarkers and improved cognitive function.

神经自身免疫疾病的诊断

Resumen de: EP3415909A1

0001 The present invention relates to a method for diagnosing a disease comprising the step detecting in a sample comprising antibodies from a patient an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a polypeptide comprising a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, or a variant thereof, a use of said polypeptide for the diagnosis of a disease, an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a use of the autoantibody for the diagnosis of a disease, a method for isolating an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a pharmaceutical composition or medical device comprising said polypeptide according to the present invention, a kit for the diagnosis of a disease comprising said polypeptide or said medical device and a use of said polypeptide or autoantibody for the manufacture of a kit or medical device.

作为神经退行性疾病的诊断和预后的标志物的p53翻译后修饰

Resumen de: US2022034912A1

The present invention refers to p53 sequence and post translational modifications (PTMs) and to their use as biomarkers in the diagnosis of neurodegenerative disease and cognitive decline and/or in the prognosis of Alzheimer's disease at different stages and/or of neurodegenerative disease in a biological sample. The invention also provides for a 1) diagnostic method based on a highly accurate mass spectrometry analysis for the diagnosis of neurodegenerative disease, including Mild Cognitive Impairment (MCI), Alzheimer's disease (AD), fronto-temporal dementia (FTD), Lewi's Body (LB), and vascular dementia (VD) in a subject, by evaluating the PTMs to the said p53 linear sequence protein and possible cut of its full sequence specifically in human plasma of patients; and 2) prognosis of AD in CU and MCI patients.

婴幼儿的特应性皮炎发病风险预测用蛋白标志物的制备方法

Resumen de: WO2025169281A1

Provided are a method for preparing a protein marker for predicting the risk of developing atopic dermatitis or the risk of allergen sensitization in infants, and a method for predicting the risk of developing atopic dermatitis or the risk of allergen sensitization using said protein marker.　More specifically, the method for preparing a protein marker for predicting the risk of developing atopic dermatitis includes recovering at least one kind of protein selected from FGG, FGA, FGB, FN1, IGHG1, IGHG2, IGHG3, IGHG4, C3, C4B, C7, CFB, CFH, EPX, CLC, RNASE3, RNASE2 and PRG2 from a sample collected from the skin of an infant subject.

特应性皮炎鉴别用蛋白标志物的制备方法

Resumen de: WO2025169282A1

Provided are a method for preparing a protein marker for differentiating atopic dermatitis and other skin diseases, and a method for discriminating atopic dermatitis and other skin diseases using said protein marker.　More specifically, the method for preparing a protein marker for differentiating atopic dermatitis and other skin diseases includes collecting, from a sample collected from the skin of a subject, at least one protein selected from FGG, FGA, FGB, FN1, IGHG1, IGHG2, IGHG3, IGHG4, C3, C4B, C7, CFB, CFH, EPX, CLC, RNASE3, RNASE2, and PRG2.

一种检测低丰度蛋白的方法

Nº publicación: CN122690127A 04/09/2026

Solicitante:

上海交通大学

Resumen de: CN122690127A

本发明公开了一种检测低丰度蛋白的方法，包括S1、将磁球偶联待测蛋白的捕获抗体和磷酸末端的寡核苷酸链段，得到捕获待测蛋白的微球、将捕获待测蛋白的微球、待测样品和生物素化检测抗体混合孵育；S2、酶标记，加入SA‑T4 PNKP酶，使捕获待测蛋白的微球表面标记T4 PNKP酶；S3、去磷酸化反应，洗去未结合的SA‑T4 PNKP酶，加入维生素B7置换结合在待测蛋白的微球表面的SA‑T4 PNKP，并激活T4 PNKP的去磷酸化性能，使得待测蛋白的微球表面的磷酸基团去磷酸化为羟基；S4、TdT信号放大，加入TdT酶和dTTP底物，识别待测蛋白的微球表面的羟基并进行polyT链延长；S5、荧光标记；S6、检测荧光强度以评估待测蛋白浓度；本发明提供了操作更为便捷，检测灵敏度高的低丰度蛋白的检测方法。