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一种可控降解镁合金骨支架的制备方法

Resumen de: CN121606736A

一种可控降解镁合金骨支架及其制备方法，属于生物材料领域。该方法包括：通过激光选区熔融3D打印技术制备WE43镁合金支架，并进行电解抛光；随后采用原子层沉积工艺在支架表面构建多级TiN/TiO₂纳米复合防护膜，通过控制膜级数调控降解速率。本发明制得的支架具有与人体皮质骨相匹配的压缩强度（≥130 MPa），降解均匀可控，当膜层数N≥2时，其平均降解速率≤0.5 mm/year，满足骨愈合期内力学支撑要求。该支架生物相容性良好，能促进骨整合，且无需二次手术取出，适用于各类骨缺损修复。

METHOD FOR PRODUCING A JAW MODEL INTENDED FOR MOUNTING IN AN ARTICULATOR

Resumen de: WO2022049078A1

The present invention relates to a method for producing a jaw model of a patient intended for mounting in an articulator (10), said method comprising the production of at least one jaw model (11, 12), at least one model plate (17) assigned to this jaw model and at least one articulation plate (19), which is detachably connectable to the model plate, is to be arranged approximately parallel to the model plate (17), can be inserted into an articulator (10) and is connectable to the latter, the model plate (17) and articulation plate (19) being fixable with respect to one another by an interlocking connection, and, according to the invention, the data for the jaw model being obtained digitally and the jaw model (11, 12) then being produced by means of 3D printing on the basis of these digital data. The jaw model (11, 12) is preferably produced from plastic in one piece together with the model plate (17) by means of 3D printing. The method according to the invention is simple, reliable and accurate and, as necessary, also allows for easier removal of individual tooth stumps (27, 28) from the model.

面向偏头痛的耳模3D打印与电刺激一体化治疗系统

Resumen de: CN121606824A

本发明涉及医疗设备技术领域，具体为面向偏头痛的耳模3D打印与电刺激一体化治疗系统，包括：耳廓数据采集模块采集患者耳廓的三维几何数据、耳穴定位数据及皮肤阻抗分布数据；个性化耳模生成模块通过自适应分层3D打印算法构建内置仿生弧度电极通道的个性化耳模，进行电极通道与目标耳穴的对位；智能电刺激调控模块结合改进的靶向Attention‑LSTM模型，动态调整电刺激频率、脉冲宽度及刺激强度，生成个性化电刺激方案；执行与安全监控模块将个性化电刺激方案转化为靶向电刺激物理治疗过程，并在治疗全程实施动态监控与自适应调整。由此，解决现有技术中耳廓数据采集维度单一、个性化耳模打印与适配性缺陷明显等问题。

一种具有镁含量和模量双梯度的骨组织工程支架及其制备方法与应用

Resumen de: CN121606737A

本发明提供一种具有镁含量和模量双梯度的骨组织工程支架及其制备方法与应用。该支架由磷酸三钙/白磷钙石(TCP/WH)构成的3D打印无机支架与活性纤维增强基质金属蛋白酶(MMP)响应水凝胶复合而成，将水凝胶灌注到无机支架中可形成具有镁含量和刚度双梯度。该复合支架特别适用于通过软骨内成骨机制的骨再生修复，细胞可在镁离子浓度和基质刚度的牵引下，逐步由水凝胶迁移到活性纤维，再迁移到无机支架，从而促进细胞的增殖、成软骨分化、成血管和新骨形成。本发明的制备方法包括无机支架的3D打印、活性纤维增强MMP响应水凝胶的制备及其灌注复合等步骤，该复合支架材料体系在骨再生修复领域具有潜在的应用价值。

一种生物降解的3D打印骨修复材料及其制备方法

Resumen de: CN121606739A

本发明属于生物医用工程材料领域，旨在提供一种可3D打印的生物降解骨修复材料及制备方法。生物3D打印是增材制造和生物医学交叉融合的新兴学科，通过生物3D打印得到的组织工程支架具有良好的生物相容性和优秀的生物活性。本发明将可降解骨修复材料和3D打印结合。本发明将可降解的聚乳酸和无机生物材料相融合，将聚己内酯‑ZnO静电纺丝增强材料的支撑强度，同时添加骨组织生长需要的羟基磷灰石和微量金属元素。在临床应用时，骨修复材料在细胞分裂，新组织生成期间起到支撑作用。在临床应用时，骨修复材料在细胞分裂，新组织生成期间起到支撑作用。随着修复材料在生物体内逐渐降解，其降解产物对生物体不会产生宿主反应，同时降低了患者在骨修复后需要进行二次手术取出植入材料的再次创伤和医疗费用。

METHOD FOR PRODUCING A DENTAL ARCH MODEL, DENTAL ARCH MODEL, AND ARRANGEMENT

Resumen de: WO2026046865A1

The invention relates to a method for producing a dental arch model (100) intended to be detachably arranged on an articulator plate (300) of an articulator (1), and to a corresponding dental arch model (100) and to an arrangement comprising such a dental arch model (100). The dental arch model (100) is manufactured by 3D printing and comprises a model base plate (200) formed in one piece therewith, wherein the model base plate (200) has a number of recesses (220) which each have a bearing surface (225) in the form of a concave spherical-segment surface and which correspond to a number of projections (320) that are provided on the upper side of the articulator plate (300) and each have a bearing surface (325) in the form of a convex spherical-segment surface, and the recesses (220) on the model base plate (200) are designed such that the produced dental arch model (100), when arranged on the articulator plate (300), rests exclusively with the bearing surfaces (225) in the form of a concave spherical segment surface on the bearing surfaces (325) in the form of a convex spherical segment surface at the articulator plate (300), and the model base plate (200) and the articulator plate (300) are otherwise spaced apart from one another.

NON-BRAIDED BIODEGRABLE FLOW DIVERTING DEVICE FOR ENDOVASCULAR TREATMENT OF ANEURYSM AND ASSOCIATED FABRICATION METHOD

Resumen de: US20260060688A1

A biodegradable flow diverting device (BFDD) that will regulate blood flow into an aneurysmal sac, act as a scaffold for endothelization at the neck of an aneurysm, and degrade after successful dissolution of aneurysm and remodeling of blood vessel. This BFDD and associated fabrication method have the following features: (1) This is a non-braided FDD. The pore shapes, sizes, architectures (especially at the inlet and outlet of the pores), pore densities and porosities can be controlled for the optimum performance depending on the blood vessel and aneurysmal morphologies from patient MRI images, (2) BFDD is developed on a rotary arm with programmable variable speed and diameter in conjunction with a micromotion stage (3) Fabrication system can take any material including blended/composite biomaterials by adjusting temperature of the electro-melt extruder/needle and (4) Fabrication system is compatible with CAM (computer aided manufacturing) software and able to operate based on the adapted G-code.

METHOD FOR OBTAINING A POROUS INJECTABLE SCAFFOLD BASED ON SIMILAR BIOPOLYMERS, BUT WITH DIFFERENT MELTING TEMPERATURES

Resumen de: US20260061094A1

Method for generating a porous injectable scaffold that includes providing a liquid composition of 2 phases at a temperature below 25° C., of Newtonian behavior, where the composition comprises: a liquid dispersant phase at room temperature formed by a gelatin with a low melting point, less than 15° C., functionalized with methacryloyl or methacrylamide groups; and a photoinitiator;and a dispersed phase, of microdroplets or beads in solid state, of a gelatin solution with a melting point greater than 25° C.; initiating the polymerization of the dispersing phase by light radiation; raising the temperature to 35-40° C. and allowing melting of the dispersed phase; and obtaining a porous scaffold. The formed porous scaffold and its use as a biological support for tissue regeneration/generation; as a biological matrix as a support for cells, for cell invasion; as an acellular biological matrix, a biological matrix as a mechanical support and/or a biological matrix for active components.

PROCESS FOR THE MANUFACTURING OF MICROSCALE HOLLOW METAL BODIES

Resumen de: US20260060925A1

A hollow body has a bottom, an upper end wall, and side walls extending between the bottom and the upper end wall. The upper end wall and side walls are made of metal. The cavity within the hollow body has a volume in the range between 1 picoliter to 1,000 picoliter. The upper end wall comprises at least one opening. The hollow body is suitable for encapsulating small amounts of liquid, or a small micro-electromechanical system, and may be used for the controlled release of pharmaceutical components.

WIRELESS MICROFLUIDIC SMART BANDAGE FOR EFFICIENT WOUND EXUDATE MANAGEMENT AND ANALYSIS IN HUMAN SUBJECTS

Resumen de: US20260060845A1

A wearable wound management system integrating a flexible microfluidic assembly and real-time electrochemical sensing to autonomously sample, transport, and analyze wound exudate. A Janus membrane, formed by selective deposition of perfluoroalkyl-functionalized silica nanoparticles and O2 plasma etching on a PET film, may collect fluid via its superhydrophobic wound-facing side and deliver it to a curved, wedge-shaped microfluidic channel that enhances capillary flow. Downstream, a graded PDMS micropillar array refreshes a sensing region by unidirectional fluid movement. A drop-on-demand inkjet-printed, CO2 laser-patterned flexible sensor patch may measure nitric oxide, oxygen, hydrogen peroxide, pH, temperature, and other relevant metrics. An encapsulated wireless electronic module may transmit health data for wireless monitoring. This system, combined with machine-learning analytics, may enable continuous, in situ monitoring and predictive wound classification, supporting proactive and personalized chronic wound care.

PATIENT-SPECIFIC NEURAL IMPLANTS ENGINEERED VIA 3D PRINTING TECHNOLOGY

Resumen de: WO2026049910A1

Embodiments relate to bioelectrodes designed to accommodate patient specific gyral patterns, and to methods of making and using thereof. A bioelectrode may be manufactured by obtaining a three-dimensional scan of at least a portion of a brain; identifying a target region of the brain; designing a bioelectrode model configured to fit the target region; and printing the bioelectrode based on the bioelectrode model. The bioelectrode is printed to include a top layer, a bottom layer, and an electrode layer positioned between the top layer and the bottom layer such that the top layer and bottom layer encapsulate the electrode layer. The bioelectrode may have a Young's modulus between 0.1 and 10 kPa to better mechanically match brain tissue.

System and Method for Planning and Simulating a Surgical Operation to Create a Patient-Specific Spinal Implant

Resumen de: US20260060750A1

A system and method for planning and simulating a surgical operation to create a patient-specific spinal implant are disclosed. The system comprises a remote server configured to receive patient-specific medical image data and generate a 3D mesh model of the patient's spine using algorithms that separate vertebral bodies, remove artifacts, and smooth surfaces. A doctor's computer receives the 3D mesh model and allows real-time manipulation of intervertebral spaces to achieve a desired spinal curvature. The server generates a spinal implant design with surface-mapped endplates matching the patient's vertebral anatomy, which is transmitted to a 3D printer for manufacturing. The method includes steps of receiving image data, generating and updating the 3D mesh model based on doctor input, generating the final implant design, and transmitting it for production. The invention enables the creation of patient-specific spinal implants with improved conformity and surgical outcomes.

SYSTEMS AND METHODS FOR ORTHODONTIC BRACKET DESIGN

Resumen de: US20260060783A1

In an embodiment, a method of manufacturing customized ceramic labial/lingual orthodontic brackets by additive manufacturing may comprise measuring dentition data of a profile of teeth of a patient, based on the dentition data, creating a three dimensional computer-assisted design (3D CAD) model of the patient's teeth, and saving the 3D CAD model, designing a virtual 3D CAD bracket structure model for a single labial or lingual bracket structure based upon said 3D CAD model, importing data related to the 3D CAD bracket structure model into an additive manufacturing machine, and directly producing the bracket with the additive manufacturing machine by layer manufacturing from an inorganic material including at least one of a ceramic, a polymer-derived ceramic, and a polymer-derived metal.

Resektionsschablone und Verfahren zum Rekonstruieren einer knöchernen Anatomie mit einer solchen Resektionsschablone

Resumen de: DE102024125227A1

Resektionsschablone (1) zum Rekonstruieren einer knöchernen Anatomie aus einem Transplantat (2), mit zumindest einem Segment (10), und mit zumindest einem Einsatz (12), welcher jeweils mindestens eine Bohrhülse (13) zum Vorgeben einer Position einer Bohrung im Transplantat (2) aufweisen; das zumindest eine Segment (10) einen Hauptkörper (HK), mindestens zwei im Hauptkörper (HK) angeordnete Löcher (14), und im Hauptkörper (HK) ausgebildete erste und zweite Aussparungen (15) aufweist, wobei die Aussparungen (15) zum Einsetzen von dem zumindest einem Einsatz (12) an einer vorgegebenen Position im Segment (10) vorgesehen sind, sowie Verfahren zum Rekonstruieren einer knöchernen Anatomiemit einer solchen Resektionsschablone (1).

Membran und Membrankontaktor

Resumen de: DE102024125325A1

1. Die Erfindung betrifft eine Membran (1) für einen Membrankontaktor (2), die als eine zu einer Mittelebene (ME) spiegelsymmetrische hohle Röhrenstruktur aus verzweigten Röhren (3, 3', 3", 3''', 3'''') mit beidseits der Mittelebene (ME) mehreren zur Mittelebene (ME) parallelen Verzweigungsebenen (VE) ausgebildet ist, wobei die Wandungen der Röhrenstruktur stoffpermeabel und/oder energiepermeabel sind und wobei im Bereich (B) jeder Verzweigungsebene (VE) jede in Richtung zur Mittelebene (ME) erstreckte Röhre (3, 3', 3'', 3''') in mehrere zur Mittelebene (ME) erstreckte Röhren (3', 3'', 3''', 3'''') verzweigt und die von beiden Seite der Mittelebene (ME) von der jeweils letzten Verzweigungsebene (VE) zur Mittelebene (ME) erstreckten Röhren (3'''') im Bereich (ÜB) der Mittelebene (ME) ineinander übergehen. Die Erfindung betrifft weiterhin einen Membrankontaktor (2) mit einer solchen Membran und ein Verfahren zur Herstellung einer hohlen Membran (1).

METHOD FOR PRODUCING A COLLAGEN AND SILK POLYPEPTIDE COMPOSITE STRUCTURE

Resumen de: WO2024223794A1

The present invention relates to a method for producing a collagen and silk polypeptide composite structure. In addition, the present invention relates to a collagen and silk polypeptide composite structure and uses thereof.

BAND WRAPPING DEVICE

Resumen de: WO2024226028A1

A band wrapping device forms a length of band material into a loop for automatically applying the band to a limb (e.g., wrist) of a user. The band wrapping device may receive the length of band material from a cassette receivable in the band wrapping device and can include a band transport mechanism for transporting the band material, a sealer module for sealing the band material to itself and cutting the band material to a length, and/or a ring module for reception of the limb of the user for band application. The device and its constituent components can help reduce the contact between the individual requiring a band and those applying the band, can help reduce waste by using a more precise amount of band material sized to the limb, and can help reduce the staffing requirements in areas in which the bands are to be applied.

METHOD OF DESIGNING AND MANUFACTURING A CUSTOMIZED HAND PROSTHESIS

Resumen de: WO2024224174A1

A method for designing a functional prosthesis of customized hand, for patients amputated at trans-radial level, implemented with additive manufacturing technology. The method flow for designing and developing the devices consists of the following steps: i) kinematic analysis and 3D scan of the limb contralateral to the amputated one; ii) kinematic synthesis of the planar mechanism at one active degree of freedom (GdL), modular for each finger, and optimization of the same through a global performance index (GPI); iii) prototyping of the assembly of five fingers.

一种降低裂瓷率的齿科用钴铬合金修复体3D打印工艺

Resumen de: CN121589301A

本发明的目的在于提供一种降低裂瓷率的齿科用钴铬合金修复体3D打印工艺，其中，钴铬合金粉末按重量百分比包括如下成分：Co：58‑64wt%；Cr：25‑31 wt %；Mo：5‑6 wt %；W：2‑3 wt %；Si：0.8‑1.2 wt %；Mn：0.5‑1.0 wt %；稀土氧化物：0.1‑0.3 wt %。打印工艺包括：采用如本发明所述的钴铬合金粉末预热、进行3D打印，打印过程中通过动态能量密度调制分别打印核心区、过渡区和表面区后获得修复体打印件，将钴铬合金打印件进行后处理获得钴铬合金修复体。本发明突破性结合粉末材料，3D打印工艺和后处理元素掺杂技术，显著提高金瓷结合力、实现金属与陶瓷的渐进式连接，从本质上解决界面失配问题。

临时修复体穿龈三维形态塑形工具盒及其制造方法

Resumen de: CN121587868A

本发明公开了临时修复体穿龈三维形态塑形工具盒及其制造方法。包括本体和塑形凹槽，塑形凹槽开设于所述本体上，塑形凹槽用于提供种植替代体的放置空间并模拟天然牙穿龈三维形态的结构；其中，本体包括上本体和下本体；上本体和下本体可拆卸连接；塑形凹槽包括种植替代体放置结构和穿龈轮廓成型结构，种植替代体放置结构与穿龈轮廓成型结构周边连接，种植替代体放置结构用于放置与种植体匹配的种植替代体，穿龈轮廓成型结构用于容纳与种植替代体相连接的临时修复基台，并模拟天然牙穿龈三维形态。

一种基于甲基丙烯酰化明胶的微球、其制备方法及其在生物墨水中的应用

Resumen de: CN121588283A

本发明公开了一种基于甲基丙烯酰化明胶的微球、其制备方法及其在生物墨水中的应用，该微球以甲基丙烯酰化明胶为核心基材，可选择性复合糖胺聚糖‑甲基丙烯酰化明胶和/或脂质体，通过微流控技术制备而成，所得微球尺寸均一，且复合组分可赋予微球优异的自粘附特性；进一步采用微流控技术，以基材及复合组分作为微球壳相、细胞分散液作为微球核相，制备具有核壳结构的载细胞微球，该载细胞微球能良好维持包埋细胞的正常存活与生长。基于甲基丙烯酰化明胶的微球或载细胞的基于甲基丙烯酰化明胶的微球，可作为3D打印墨水用于制备支架材料、载细胞支架材料，适配细胞三维培养、细胞球培养、高密度细胞培养及组织工程植入材料领域。

包括整体式模具主体的牙体修复模具

Resumen de: WO2025027496A1

A custom tool for forming a dental restoration in a mouth of a patient includes a one-piece mold body providing for a customized fit with at least one tooth of the patient, the one-piece mold body including an occlusal portion forming an occlusal surface corresponding with an occlusal surface of the tooth, a mesial proximal portion forming a mesial proximal surface corresponding with a mesial proximal surface of the tooth, and a distal proximal portion forming a distal proximal surface corresponding with a distal proximal surface of the tooth. The mold body is configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of the tooth. The occlusal portion, the mesial proximal portion, and the distal proximal portion are based on three-dimensional scan data of the mouth of the patient.

一种用于挤出3D打印的光-酸协同增强生物墨水及其制备方法

Resumen de: CN121592122A

本发明公开了一种用于挤出3D打印的光‑酸协同增强生物墨水及其制备方法。该墨水由N‑乙烯基吡咯烷酮（NVP）、聚乙烯醇（PVA）、光引发剂及具有“单羟基‑双羧基”特异结构的苹果酸组成。打印时，墨水经挤出并结合紫外光照射实现初步定型，随后在加热油性支撑浴中同步触发酸催化NVP深度聚合及PVA微晶化，一步完成光固化定型与热处理增强。本发明利用苹果酸独特的分子结构构建了高效的光‑酸协同增强机制，不仅显著提升了单体转化率，更通过物理‑化学双网络大幅增强了打印体的力学强度与形状保真度，有效解决了生物墨水可打印性与强度的矛盾，在组织工程、柔性电子等领域具有广阔应用前景。

一种人工血管打印方法及设备

Resumen de: CN121590022A

本发明涉及人工血管制造的技术领域，具体而言，公开了一种人工血管打印方法及设备包括：第一储液部件，用于储存芯相材料；第二储液部件，用于储存外相材料；同轴打印组件，具备同轴设置的内料管和外料管，内料管连接第一储液部件，外料管连接第二储液部件；压力源，连通第一储液部件和第二储液部件，用于提供压力；接收部件，设置于同轴打印组件下方，用于接收人工血管；光固化组件，设置于接收部件的一侧，用于固化人工血管；通过使用本发明，能够复现天然管状组织复杂的解剖学特征，能够防止微小血栓的产生；且能够有效避免造成微通道堵塞，避免影响制备精度和效率，能够兼顾血管结构的生物相容性和高机械强度。

一种3D打印用的医用级PEEK复合材料及其制备方法

Nº publicación: CN121592153A 03/03/2026

Solicitante:

北京国科神州医学科学技术院百色学院

Resumen de: CN121592153A

本发明公开了一种3D打印用的医用级PEEK复合材料及其制备方法，涉及3D打印技术领域，解决了现有PEEK材料存在的生物活性低的问题。该医用级PEEK复合材料由以下重量份的原料制成：聚醚醚酮基体80～95份、生物活性填料5～15份、界面改性剂0.5～5份、导热与成核增强剂0.1～3份；所述生物活性填料包括重量比为（1～5）:（5～1）的纳米羟基磷灰石和生物活性玻璃。能够有效模拟天然骨环境，提高复合材料的生物活性，促进细胞黏附与增值，从而提高细胞增值率，还能有效提高了复合材料的抑菌效果和力学性能。