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LastUpdate Última actualización 03/05/2025 [07:09:00]
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PERSISTENT SANITIZER

NºPublicación:  US2025134097A1 01/05/2025
Solicitante: 
THOMAS DOUGLAS WESCOTT [US]
MAHRAT REEM [US]
Thomas Douglas Wescott,
Mahrat Reem
US_2025134097_PA

Resumen de: US2025134097A1

Provided herein are compositions and related methods related to a class of formulation that can be applied once a day and still provide antimicrobial and/or antiviral protection during this period, thus exhibiting persistent sanitization to the user. In some embodiments, a hand cream with antimicrobial and/or antiviral protection can prevent against COVID-19 spread or infection. In some embodiments, the formulation comprises one or more of the following: benzalkonium chloride, zinc oxide, tributyl phosphate, soybean oil, and/or Triton X-100, or an analog, derivative, salt, or pharmaceutical equivalent thereof, with the formulation containing a predominance of water to prevent a greasy feel to the user.

COMBINATION OF IAP INHIBITORS AND CELLULAR KINASE INHIBITORS, SUCH AS PONATINIB, FOR USE IN THE TREATMENT OF CANCER OR PULMONARY DISEASES, SUCH AS COPD, CYSTIC FIBROSIS, PULMONARY FIBROSIS AND COVID-19

NºPublicación:  WO2025090605A1 01/05/2025
Solicitante: 
UNIV OF HOUSTON SYSTEM [US]
TRACT PHARMACEUTICALS INC [US]
UNIVERSITY OF HOUSTON SYSTEM,
TRACT PHARMACEUTICALS, INC
WO_2025090605_A1

Resumen de: WO2025090605A1

The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

USE OF NOVEL POLYMER FOR PREVENTING SARS-COV-2

NºPublicación:  US2025134989A1 01/05/2025
Solicitante: 
POSTECH RES AND BUSINESS DEVELOPMENT FOUNDATION [KR]
KOREA NAT INSTITUTE OF HEALTH [KR]
KOREA NAT INSTITYTE OF HEALTH [KR]
POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION,
Korea National Institute of Health,
Korea National Instityte of Health
US_2025134989_A1

Resumen de: US2025134989A1

The present invention relates to a novel vaccine composition for coronavirus infection-19 comprising a polymer-based mRNA carrier. Specifically, the present invention provides a vaccine composition comprising an mRNA carrier using a novel polymer capable of delivering a negatively charged genetic material such as mRNA, and the vaccine composition has excellent effects of enhanced in vivo immune activity such as high antibody formation ability and increased interferon-gamma production.

COMPOSITION FOR TREATING CORONAVIRUS DISEASE 2019 (COVID-19) CONTAINING TAURODEOXYCHOLIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND ANTIVIRAL AGENT AS ACTIVE INGREDIENTS

NºPublicación:  US2025134910A1 01/05/2025
Solicitante: 
SHAPERON INC [KR]
SHAPERON INC
US_2025134910_PA

Resumen de: US2025134910A1

The present invention relates to a composition for treating coronavirus infection-19 (COVID-19), comprising taurodeoxycholic acid (TDCA) or a pharmaceutically acceptable salt thereof and an antiviral agent as active ingredients, it was confirmed that clinical symptoms were cured in patients with COVID-19 pneumonia who were administered a combination of a pharmaceutically acceptable salt of taurodeoxycholic acid as an inflammasome inhibitor and an antiviral agent, and thus this combination of taurodeoxycholic acid (TDCA) or a pharmaceutically acceptable salt thereof as an inflammasome inhibitor and an antiviral agent, holds promise as active ingredients in compositions for the prevention or treatment of lower respiratory tract infectious diseases, including COVID-19.

MEMBRANE FUSION AND IMMUNE EVASION BY THE SPIKE PROTEIN OF SARS-COV-2 DELTA VARIANT

NºPublicación:  US2025134985A1 01/05/2025
Solicitante: 
CHILDRENS MEDICAL CENTER CORP [US]
Children's Medical Center Corporation
US_2025134985_PA

Resumen de: US2025134985A1

Provided herein, in some aspects, are methods for using the receptor-binidng domain (RBD) of the SARS-COV-2 S protein, including the the RBD-1, RBD-2, and/or RBD-3 regions, to identify therapeutics for the treatment of SARS-COV-2, developing a vaccine for the treatment or prevention of SARS-COV-2, and identifying a patient as being in need for a treatment for SARS-COV-2.

COMPOSITIONS AND METHODS FOR VACCINATION AGAINST PATHOGENIC CORONAVIRUS SPECIES AND VARIANTS

NºPublicación:  US2025134987A1 01/05/2025
Solicitante: 
YALE UNIV [US]
Yale University
US_2025134987_PA

Resumen de: US2025134987A1

The current disclosure includes coronavirus vaccines that protect against pathogenic coronavirus species, as well as their variants. In certain embodiments, SARS-CoV-2 variant specific and multivalent coronavirus vaccines are described. The vaccines typically include a modified mRNA which encodes at least one coronavirus derived immunogen, such as a spike protein or a fragment thereof. The mRNA can be encapsulated into lipid nanoparticles or other carriers and formulated as pharmaceutical compositions which can be used to generate an immune response to coronavirus in a subject. The vaccines can be used to elicit potent B and T cell responses against SARS-CoV-2 variants and to confer protective immunity against SARS-CoV-2, as well as other pathogenic coronavirus species such as SARS-CoV and/or MERS-CoV.

COMPOSITIONS AND METHODS FOR SUPPORTING IMMUNE HEALTH

NºPublicación:  US2025134945A1 01/05/2025
Solicitante: 
PLEXUS WORLDWIDE LLC [US]
Plexus Worldwide, LLC
US_2025134945_PA

Resumen de: US2025134945A1

Various embodiments provide a method of increasing immunity to a virus in a subject. The method can comprise administering to the subject one or more effective doses of an immune-enhancing natural-based composition; thereby stimulating increased expression one or more of IFN-γ, IL-1B, IL-6, IL-10, IL-12p40, IL-12p70, and TNF-α; inhibiting replication of the virus inside a cell of the subject, and preventing entry of virus into the cell. The method of increasing immunity can further comprise increasing immunity to an upper respiratory tract viral infection. The upper respiratory tract viral infection can be COVID-19. According to some aspects of the method of increasing immunity, the effective dose of the immune-enhancing natural-based composition comprises: 30-70 mgs of cyanidin-3-glucosides; 40-80 mgs of andrographolides; 75-125 mgs of ascorbic acid; 400-600 mgs of beta glucans; 300-500 mgs of polysaccharides; and 75-125 mgs of a blend of antioxidants.

TEA FRACTION FOR TREATING IDIOPATHIC PULMONARY FIBROSIS

NºPublicación:  US2025134944A1 01/05/2025
Solicitante: 
GT COMFORT HEALTH CORP [TW]
GT COMFORT HEALTH CORP
US_2025134944_PA

Resumen de: US2025134944A1

The present invention provides a new tea fraction, which is made from the non-ethanol extract, and does not contain caffeine, epigallocatechin gallate (EGCG), gallic acid and catechin that are usually found in conventional tea extracts. The tea fraction has an efficacy in treating a lung fibrosis, particularly idiopathic pulmonary fibrosis (IPF), Covid-19 and long Covid.

TRANSGENIC SEEDS FOR INHIBITING VIRAL REPLICATION VIA ANTICOMMUNICABLE FORTIFICATION SYSTEM (ACF SYSTEM) WITH CONCOMITANT METHOD OF TREATMENT OR PREVENTION OF VIRAL DISEASE, AND PANDEMIC PREVENTION AND ELIMINATION

NºPublicación:  US2025137007A1 01/05/2025
Solicitante: 
KOTLYAR DAVID [US]
Kotlyar David
US_2025137007_PA

Resumen de: US2025137007A1

Disclosed is an alternate method of prevention and treatment of diseases caused by viral pathogens of human being and animals including coronaviruses, influenza viruses, etc., by food supplementation or fortification of food with foodstuff derived from transgenic plants or parts thereof obtained from the presently disclosed transgenic plant seed. This method provides said transgenic plant seed, wherein the genome of said seed comprises an exogenous recombinant polynucleotide encoding a combination of polypeptides, which are carbohydrate binding proteins, particularly lectins that in combination as disclosed herein are combined in a manner to overcome potential toxicity caused by their transgenic expression and to lower the concentrations of each of the carbohydrate binding proteins when expressed as a part of the combination when compared to the individual transgenic expression of any of said carbohydrate binding proteins, and wherein said seed exhibit inhibition of viral replication and provide immunity against viral pathogens.

DIAGNOSTIC ASSAY METHODS USING ASSAY DEVICE HAVING MICROREACTOR

NºPublicación:  US2025138005A1 01/05/2025
Solicitante: 
ACCESS BIO INC [US]
Access Bio, Inc
US_2025138005_PA

Resumen de: US2025138005A1

Diagnostic assay devices for detecting the presence of an analyte in a sample solution may comprise a microreactor configured to form a sample solution containing the analyte, flow the sample solution therethrough in a first direction to form an analyte-capture molecule complex, and transfer the sample solution to an absorbent strip pad configured to flow therethrough, in a second direction crossing the first direction, the sample solution including the analyte-capture molecule complex and indicate a presence of the analyte-capture molecule complex. The diagnostic devices may be used, for example, to identify the presence of SARS-Cov2, RSV, influenza A, influenza B or other pathogens in samples from patients.

COMPOSITIONS, KITS, AND METHODS FOR DUPLEX IMMUNOASSAY FOR ANTI-SARS-COV-2 ANTIBODIES

NºPublicación:  US2025138011A1 01/05/2025
Solicitante: 
SIEMENS HEALTHCARE DIAGNOSTICS INC [US]
Siemens Healthcare Diagnostics Inc
US_2025138011_PA

Resumen de: US2025138011A1

Kits containing a multiplexed chemiluminescent detection system and microfluidics devices and methods for detecting the presence and/or concentration of anti-SARS-CoV-2 antibodies in a sample are disclosed. The kits, microfluidics devices, and methods utilize singlet oxygen-activatable chemiluminescent compounds in combination with two or more fluorescent molecules that emit light at different wavelengths. In certain non-limiting embodiments, the kits, microfluidics devices, and methods can distinguish between anti-SARS-CoV-2 antibodies generated in response to vaccination from anti-SARS-CoV-2 antibodies generated in response to infection.

Using Exhaled Breath Condensate for Testing for a Biomarker of COVID-19

NºPublicación:  US2025138004A1 01/05/2025
Solicitante: 
DANIELS JOHN J [US]
Daniels John J
US_2025138004_PA

Resumen de: US2025138004A1

An apparatus for detecting a biomarker comprises a droplet harvesting structure for converting breath vapor to a fluid droplet for forming a fluid sample and a testing system having a biomarker testing zone for receiving the fluid sample and detecting a biomarker. The droplet harvesting structure may include at least one of a hydrophobic field for receiving the breath vapor and forming the fluid droplet from the received breath vapor and hydrophilic channels for receiving the fluid droplet and channeling the fluid droplet towards the testing system. A fluid dam member may be provided disposed between the droplet harvesting structure and the biomarker testing zone.

MONOCLONAL ANTIBODIES SPECIFIC FOR FAS LIGAND AND USES THEREOF

NºPublicación:  AU2023372393A1 01/05/2025
Solicitante: 
PROVIDENCE HEALTH & SERVICES OREGON
PROVIDENCE HEALTH & SERVICES - OREGON
AU_2023372393_PA

Resumen de: AU2023372393A1

Monoclonal antibodies that specifically bind to and block the function of Fas ligand (FasL) are described. The FasL-specific antibodies can be used for the development of therapeutics for the treatment of diseases, disorders and conditions associated with the Fas/FasL signaling pathway, such as cancer, sepsis, ischemia-reperfusion injury, and coronavirus disease 2019 (COVID-19).

METHOD FOR DEVELOPING OPTIMER-BASED ELECTROCHEMICAL BIOSENSOR

NºPublicación:  WO2025090048A1 01/05/2025
Solicitante: 
EGE UENIVERSITESI IDARI VE MALI ISLERDAIRE BSK [TR]
EGE \u00DCN\u0130VERS\u0130TES\u0130 \u0130DAR\u0130 VE MAL\u0130 \u0130\u015ELERDA\u0130RE B\u015EK
WO_2025090048_A1

Resumen de: WO2025090048A1

The invention relates to an optimer-based electrochemical biosensor for use in the determination of SARS-CoV-2 S1 protein and Moxifloxacin as well as the method for its operation. The invention also includes an application of said method for the diagnosis of disease and the determination of drugs. In this context, SARS-CoV-2 S1 protein and Moxifloxacin were selected as target analytes and electrochemical analyses of these target analytes were performed using optimer-based procedure and electrochemical impedance spectroscopy technique.

PEPTIDE SET FOR SIMULTANEOUS QUANTITATIVE ANALYSIS OF ANTIGEN PROTEINS OF PLURALITY OF SARS-COV-2 SUBTYPES, AND ANTIGEN PROTEIN ANALYSIS METHOD USING SAME

NºPublicación:  WO2025089473A1 01/05/2025
Solicitante: 
EYEGENE INC [KR]
\uC544\uC774\uC9C4 \uC8FC\uC2DD\uD68C\uC0AC
WO_2025089473_PA

Resumen de: WO2025089473A1

The present invention provides: a peptide set for quantifying and analyzing antigen proteins of individual subtypes from a specimen containing antigen proteins of a plurality of SARS-CoV-2 subtypes; and a method for simultaneously and quantitatively analyzing antigen proteins of SARS-CoV-2 subtypes according to types thereof, using same. The peptide set comprises one or more peptides specific to individual SARS-CoV-2 subtypes, selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 3, and a peptide common to SARS-CoV-2 subtypes, selected from SEQ ID NO: 4 or SEQ ID NO: 5.

TEA FRACTION FOR TREATING IDIOPATHIC PULMONARY FIBROSIS

NºPublicación:  WO2025086933A1 01/05/2025
Solicitante: 
GT COMFORT HEALTH CORP [CN]
GT COMFORT HEALTH CORP
WO_2025086933_A1

Resumen de: WO2025086933A1

The present invention provides a new tea fraction, which is made from the non-ethanol extract, and does not contain caffeine, epigallocatechin gallate (EGCG), gallic acid and catechin that are usually found in conventional tea extracts. The tea fraction has an efficacy in treating a lung fibrosis, particularly idiopathic pulmonary fibrosis (IPF), Covid-19 and long Covid.

Composition for Prevention and Treatment of Bacterial and Viral Infections and Inflammation

NºPublicación:  US2025134924A1 01/05/2025
Solicitante: 
CUDDEBACK DAVID A [US]
Cuddeback David A
US_2025134924_A1

Resumen de: US2025134924A1

Compositions and methods for protecting against a wide spectrum of viral and bacterial infections, including Covid-19, and for treating established infection and infectious inflammation are described. The composition includes a novel combination of vitamins, minerals, nutraceuticals, and phytochemicals, which may be compounded as a pill, tablet, powder, capsule or liquid to be taken orally or via other administration routs one or more times per day, to serve as immune boosters, antibacterial agents, and antiviral agents along with providing anti-inflammatory effects in humans and animals.

PHARMACOLOGICAL AGONIST OF KLF2 REDUCES OSTEOCLAST DIFFERENTIATION, INFLAMMATION, AND COVID

NºPublicación:  WO2025090967A1 01/05/2025
Solicitante: 
TEXAS TECH UNIV SYSTEM [US]
LONG ISLAND UNIV [US]
TEXAS TECH UNIVERSITY SYSTEM,
LONG ISLAND UNIVERSITY
WO_2025090967_PA

Resumen de: WO2025090967A1

Provided herein are compositions and methods for treating musculoskeletal disorder such as arthritis, rheumatoid arthritis, osteoporosis, wound healing, corneal epithelial dystrophies and injuries, and cytokine storm with a molecule of formula: and one or more pharmaceutical acceptable excipients or salts; and methods for preventing and/or treating musculoskeletal disorder such as arthritis, rheumatoid arthritis, osteoporosis, wound healing, corneal epithelial dystrophies and injuries, and cytokine storm triggered by a coronavirus 2 (SARS-CoV-2) infection or fibrosis in a subject.

NUTRACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF SUBJECTS OVER 50 WITH CHRONIC FATIGUE

NºPublicación:  WO2025088482A1 01/05/2025
Solicitante: 
PHARMANUTRA S P A [IT]
PHARMANUTRA S.P.A
WO_2025088482_A1

Resumen de: WO2025088482A1

The present invention relates to a composition, preferably a nutraceutical composition, for use in a method of treatment of subjects over 50 suffering from chronic fatigue, particularly due to: arthritis/chronic arthritis; heart disease; post-operative convalescence; depression; diabetes; fibromyalgia; chronic rheumatic diseases; stroke; cerebral ischemia; respiratory failure; chronic respiratory disease; allergic diseases; overweight/obesity; drug use, wherein said subjects are not suffering from Long-Covid/fatigue post Covid-19 syndrome.

ANTIBODY SPECIFIC TO SPIKE PROTEIN OF SARS-COV-2 AND USES THEREOF

NºPublicación:  US2025136668A1 01/05/2025
Solicitante: 
ACAD SINICA [TW]
ACADEMIA SINICA
US_2025136668_PA

Resumen de: US2025136668A1

The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.

PEPTIDE WITH NEUTRALIZING ACTIVITY AGAINST SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2

NºPublicación:  EP4545971A2 30/04/2025
Solicitante: 
CAREGEN CO LTD [KR]
Caregen Co., Ltd
EP_4545971_A2

Resumen de: EP4545971A2

The present invention relates to a peptide that specifically recognizes a protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or a portion thereof; a composition for preventing or treating SARS-CoV-2 infection, comprising the peptide; and a composition for detecting SARS-CoV-2, comprising the peptide.

PEPTIDE WITH NEUTRALIZING ACTIVITY AGAINST SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2

NºPublicación:  EP4545970A2 30/04/2025
Solicitante: 
CAREGEN CO LTD [KR]
Caregen Co., Ltd
EP_4545970_A2

Resumen de: EP4545970A2

The present invention relates to a peptide that specifically recognizes a protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or a portion thereof; a composition for preventing or treating SARS-CoV-2 infection, comprising the peptide; and a composition for detecting SARS-CoV-2, comprising the peptide.

CYCLOBENZAPRINE TREATMENT FOR POST-ACUTE SEQUELAE OF (SARS)-COV-2 INFECTION (PASC)

NºPublicación:  EP4543427A1 30/04/2025
Solicitante: 
TONIX PHARMACEUTICALS HOLDING CORP [US]
Tonix Pharmaceuticals Holding Corp
AU_2023286504_A1

Resumen de: AU2023286504A1

The present disclosure provides methods for treating Post-Acute Sequelae of Severe Acute Respiratory Syndrome (SARS)-CoV-2 infection (PASC) or one or more symptoms associated with said PASC, comprising administering to a subject in need or at risk thereof a pharmaceutical composition comprising a therapeutically effective amount of cyclobenzaprine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

ANTI-SARS-COV-2 HUMAN MONOCLONAL ANTIBODY, PHARMACEUTICAL COMPOSITION, DIAGNOSTIC KIT AND USE THEREOF

NºPublicación:  EP4545559A2 30/04/2025
Solicitante: 
INST BUTANTAN [BR]
INSTITUTO BUTANTAN
EP_4545559_PA

Resumen de: EP4545559A2

The present invention is part of the field of genetic engineering, more specifically, in the field of production of anti-sars-cov-2 human monoclonal antibodies. The neutralizing human antibodies of the present application can be used in the therapy of COVID19, avoiding hospitalization and aggravation of infected people with a predisposition to develop severe disease. Persons who are not infected but at risk (health and safety professionals, and others) may benefit from preventive treatment. The present invention also relates to a pharmaceutical composition comprising anti-SARS-COV-2 human monoclonal antibodies, as well as a diagnostic kit and use thereof.

PEPTIDE WITH NEUTRALIZING ACTIVITY AGAINST SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2

Nº publicación: EP4545969A2 30/04/2025

Solicitante:

CAREGEN CO LTD [KR]
Caregen Co., Ltd

EP_4545969_A2

Resumen de: EP4545969A2

The present invention relates to a peptide that specifically recognizes a protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or a portion thereof; a composition for preventing or treating SARS-CoV-2 infection, comprising the peptide; and a composition for detecting SARS-CoV-2, comprising the peptide.

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