Resumen de: CN122851968A
本发明公开了一种机械臂辅助式多流道原位生物打印喷头,包括法兰盘、主体支撑框架、控制单元、挤出单元、切换阀体及蓝光模组;法兰盘下方固接主体支撑框架,其外周壁均布支撑翼板并安装阀盖和伺服电机,伺服电机驱动旋转阀芯转动,阀芯内设L型导流通道,转动阀芯使L型通道进口与任一进料流道对接,出口与中心出料流道连通;支撑翼板下方固定挤出单元,各单元集成驱动、温控模块,并通过柔性软管与进料流道连通;中心出料流道下端连接点胶针头;切换阀体底部固设蓝光模组支架,其上均布有多个朝向针头的灯珠模块。本发明结构紧凑,集成多材料按需切换、精准挤出、温控及原位光固化功能,适用于复杂组织工程支架的原位生物打印。
Resumen de: CN122863642A
本申请公开了头部电极的电极帽头架的生成方法、装置、设备、产品及存储介质,所述方法包括从脑影像中提取头皮表面的坐标,基于预设解剖标志点构建变换矩阵并将多个电极的坐标变换到头部空间并投影到头皮表面,确定多个电极在所述头皮表面的电极位置;构建电极座模型,基于电极邻接字典提取拟定电极集合中的电极间的有效边和进一步确定连接边,构建连接边的结构路径以在其上的多个采样点构建连接带截面,连接截面以构建连接带模型,合并电极位置、电极座模型和连接带模型得到头架模型;控制制造设备利用头架模型生成电极帽头架。所述方法根据个体脑影像自动化生成头架,实现其中电极放置的个性化,消除人工测量带来的定位偏差,同时具有良好佩戴效果。
Resumen de: CN122848465A
本发明公开了一种缓解视疲劳的药食同源功能性多重乳液凝胶及其制备方法和应用,属于食品加工技术领域。本发明采用亲水性低共熔溶剂提取并负载枸杞多糖和花青素,以亲油性低共熔溶剂提取并负载叶黄素酯和水飞蓟素;其中亲油性低共熔溶剂由十二烷酸与薄荷醇复配而成,利用十二烷酸的质子化/去质子化转变实现胃肠道pH响应释放;凝胶体系采用燕麦β‑葡聚糖与低DE值麦芽糊精复配,利用二者弱热力学不相容性使麦芽糊精物理截留于β‑葡聚糖凝胶网络孔隙中,赋予凝胶温度响应与口腔酶响应特性。该凝胶通过温度‑酶‑pH三响应实现加工成型、安全吞咽与肠道精准释放,适用于吞咽困难老年人群的视疲劳缓解与视力保护。
Resumen de: CN122850812A
本发明提供一种钛合金外冠及其加工方法和应用,属于口腔修复体精密制造、增材制造与数控复合加工技术领域。该钛合金外冠的加工方法基于“3D打印+五轴数控机加工”复合加工方法,3D打印负责外冠主体结构及复杂内腔的快速近净成型,充分发挥增材制造在成型复杂几何特征上的优势,大幅减少材料损耗与成型工时;五轴数控机加工则专门负责外冠关键功能面的精密加工,充分发挥减材制造在尺寸精度和表面质量上的优势,两种工艺各司其职、优势互补,从根本上解决了单一工艺无法同时兼顾复杂结构成型与精密功能面加工的行业难题;且打印、机加工、装配检验过程中坯体与工装始终保持固连状态,通过工装流转,实现增材制造与减材加工全流程基准统一。
Resumen de: CN122849549A
本发明涉及生物医用材料及3D生物打印技术领域,具体涉及一种3D打印再造鼻翼软骨GelMA复合生物墨水。该生物墨水包括聚乙烯醇PVA、甲基丙烯酸化明胶GelMA和纳米二氧化硅SiO2,其中PVA形成支撑骨架,GelMA经光交联形成柔性网络,纳米SiO2分散于复合体系中以增强支架力学性能。通过流变学测试匹配18G喷嘴、打印速度和层厚,并依据受术者CT或MRI数据建立个体化鼻翼软骨三维模型,逐层打印形成孔隙率达80%以上的多尺度多孔仿生支架。所得支架兼具连续挤出性、形状保持性、软骨样弹性及细胞相容性,可提高与目标软骨组织的力学匹配程度,并为软骨细胞迁移、黏附、增殖及新生软骨形成提供适宜空间。
Resumen de: WO2025199336A1
Methods and systems are provided for generating an enhanced 3D visualization of pathologies detected in a medical imaging examination. In accordance with one method, one or more Al algorithms may be applied to an image volume to detect a pathology in the anatomy, and prior to rendering the image volume for display, information about the pathology may be extracted from findings of the one or more Al algorithms, and different, customized rendering parameters may be calculated for the pathology and for each organ and/or system of a plurality of organs and/or systems surrounding the pathology, based on the extracted information. The image volume may then be rendered on a display device based on the customized rendering parameters.
Resumen de: WO2025188503A1
Systems and methods to improve programming of medical devices and delivery of cardiac pacing are disclosed, including receiving parameter settings of an ambulatory medical device, processing the received parameter settings by inputting the received parameter settings into one or more pre-trained machine learning models to identify one or more differences between the parameter settings of the ambulatory medical device and the model parameter settings of one or more other ambulatory medical devices, and generating a programming recommendation for the ambulatory medical device to improve cardiac capture for the patient based on the identified one or more differences.
Resumen de: MX2026008662A
A method of providing a personal medication injection system is disclosed. The method comprises determining at least one anthropometric characteristic of a person and providing a plurality of types of personal medication injection systems. Each personal medication injection system of a personal medication injection system type is configured to conform to a body part of the person that is intended to receive an injectable medicament and includes a set of medication injection locations including at least one defined medication injection location corresponding to a location of a medication injection site on the person's body part when the personal medication injection system is disposed on the person's body part. Each type of personal medication injection system is associated with a defined range of anthropometric features that is different from the defined range of anthropometric features associated with the other types of personal medication injection systems, and each type of personal medication injection system has a set of associated medication injection locations that is different from the set of medication injection locations of the other types of personal medication injection systems. The method also involves using the determined anthropometric feature and the defined ranges of anthropometric features to select one of the types of personal medication injection systems of the plurality of types of personal medication injection systems already manufactured, and providing t
Resumen de: WO2025147712A1
The present disclosure relates generally to oral tissue repair compositions and implants thereof; and, more particularly, to customized acellular extracellular matrix repair compositions and implants for patient-specific treatment of various oral tissue defects, such as periodontal recession.
Resumen de: MX2026008087A
A system, method, and apparatus are disclosed for determining positions of medical devices within a hub, which comprises a number of apparatuses that are linked together in a stacked configuration. A medical device hub includes a connectivity apparatus that is communicatively coupled to a medical network and/or a monitoring device. Additionally, the medical device hub includes one or more docking apparatuses. Each docking apparatus can accommodate two or more infusion pumps. The number of docking apparatuses used in the medical device hub depends on the number of infusion pumps needed for a patient treatment. The medical device hub enables multiple docking apparatuses to be stacked as needed while enabling the infusion pumps to be operated independently and removed from the medical device hub as needed, even during a treatment without interruption. Such a configuration provides a scalable, flexible, and adaptable system that aggregates infusion pumps into a relatively small footprint.
Resumen de: MX2026003539A
Computer-implemented method, computer program product, and computer system (100) for generating a three-dimensional digital model of the patient (210) of the patient's oral anatomy with the patient (1) having a first mandibular arch at least semi-edentum, and having at least one first dental implant positioned in the bone of the mandibula of said first mandibular arch at least semi-edentum, and having a prosthesis applied to the mandibular arch at least semi-edentum. The system receives a second set of three-dimensional intraoral surface scan data (202) obtained from the mandibular arch of the patient opposite at least the first semiedentate mandibular arch in a non-occluding state and a third data set (203) comprising representations of both mandibular arches in an occlusion state. A fourth set of three-dimensional intraoral surface data (204) of at least portions of the surface of the science (204-g) in said first mandibular arch is received at least semi-edentum and with surface information of a first implant head interface (204-1, 204-2, 204-3, 204 4) of the at least one first implant located in the at least semi-edentate mandibular arch. A fifth set of three-dimensional 4p surface data (205) of the prosthesis is received with surface information of at least a first stop interface (205-1, 205-2, 205-3, 205-4) configured to positively engage with the implant head interface (204-1, 204-2, 204-3, 204-4). The digital patient aligns the fourth three-dimensional intraoral surfa
Resumen de: US20260272563A1
0000 Pulse field ablation (PFA) guidance is generated from intracardiac echocardiogram (ICE) imaging. The relative position of the PFA device and the tissue is determined. The treatment placement with respect to the tissue for repetitive application is detected. By finding the relative position and/or treatment placement over time, ICE imaging in combination with image processing may provide visual guidance rather than just imaging or just catheter tracking for PFA. The resulting PFA procedure may be more likely complete and/or optimized.
Resumen de: MX2026006230A
Embodiments herein relate to patient characteristics that are indicative of CAR-T cell manufacturing qualities. In certain aspects, parameters are collected and input through a trained algorithm to determine various attributes of the CAR T drug product. Such determinations may be used to optimize the manufacturing process for the CAR T drug product by adjusting various manufacturing parameters.
Resumen de: MX2026010471A
A method of treating psoriatic arthritis in a patient by administering an IL-23 specific antibody, e.g., guselkumab, in a clinically proven safe and clinically proven effective amount and the patient achieves significant ACR20/50/70, PASI70/90/100, MDA, HAQ-DI, SF-36 PCS, MCS, LEI/dactylitis, PASDAS, GRACE, mCPDAI, DAPSA or RAPID3 improvement as measured 16, 24, 32, 40 and 48 weeks after initial treatment.
Resumen de: WO2022076300A1
A system for securely accessing a fluid injection system is disclosed. The system includes at least one processor programmed or configured to authenticate a user for access to an fluid injection system, provide data identifying one or more features of a software application for accessing the fluid injection system, receive data identifying a selected feature of the software application for accessing the fluid injection system, and provide access to the selected feature of the software application for accessing the fluid injection system.
Resumen de: FR3146366A1
Titre de l’invention Boîtier de surveillance des fluides médicaux dans un hôpital embarquant des moyens de communication amovibles L’invention concerne un boitier de surveillance de fluide (3) comprenant des moyens de pilotage (4) à carte électronique principale (40), des moyens de raccordement électrique (17) pour le raccordement de capteurs de pression (5), et des liaisons électriques (16) pour raccorder les moyens de raccordement électrique (17) aux moyens de pilotage (4). La carte électronique principale (40) comprend un emplacement à module (43) pour y raccorder un module de télécommunication (30) amovible comprenant une carte électronique secondaire (31) portant des moyens de télécommunication (32). Le module de télécommunication (30) coopère, via la carte électronique secondaire (31), avec les moyens de pilotage (4) pour transmettre des informations vers un équipement de surveillance distant (50). Utilisation de ce boitier (3) pour surveiller un réseau de fluides hospitalier (14) d’un établissement hospitalier (60). Figure d’abrégé : Fig. 3
Resumen de: CN122863467A
0001 本发明属于帕金森病状态的监测技术领域,公开了一种基于多模态信号的帕金森病状态的监测方法及监测系统,通过采集患者的生化信号、物理信号,对标准化物理张量、标准化化学张量分别进行多分支特征提取得到物理特征、化学特征;利用物理感知门控网络模型中的门控网络对输入的物理特征进行处理,输出自适应生成的物理权重以及与物理权重互补的化学权重,使得两个特征权重互补融合,实现对通道信噪比的动态调配,克服单一物理信号易混淆病理性震颤与日常伪影的缺陷。利用元素级乘法得到融合特征;将融合特征输入全连接层进行状态识别,输出状态类别。克服了生化分泌药代动力学与物理症状表现之间的时空错位,构建多维度、抗干扰的评价体系。
Resumen de: US20260297020A1
The invention relates to a radically polymerisable compound represented by a structure of formula 1: PG-Sp-PCA-Sp-OG (O) NH—K—NHC (O) O-Sp-PCA-Spn-PG (formula 1), wherein PG=in each case independently selected from a radically polymerisable group, R1=selected from hydrogen, a C1-C8 alkyl group, an aryl group and an araliphatic group having C6-C8 carbon atoms, R2=selected from hydrogen, a C1-C4 alkyl group; Sp=in each case independently of one another a spacer group selected from unbranched and branched alkylene with C1-C19 carbon atoms, which may additionally contain oxygen, sulfur and/or —OOC— in the carbon chain, or Sp is absent; PCA=in each case independently of one another a polycyclic group; K=an aliphatic acyclic, saturated or unsaturated unit having C1-C15 carbon atoms, an aliphatic cyclic, saturated or unsaturated unit having C3-C15 carbon atoms, or an aromatic or araliphatic unit having C6-C14 carbon atoms; n=1 to 9. The invention also relates to a process for preparing such a compound, a radically polymerisable composition containing such a compound, the use thereof and a cured dental material.
Resumen de: US20260294587A1
0000 Provided is a dental-treatment index that enables high-quality tooth crown restoration regardless of the skill of a practitioner. A dental-treatment index 10 according to the present invention is composed of a material through which light transmits, and has two fixing outer surfaces 13 and a tooth-shaped hole 14 provided in an internal surface 11a between said two fixing outer surfaces 13. Each of the fixing outer surfaces 13 is provided with a guide part 13a . A dental-treatment index fixing holder 20 is composed of a material through which light transmits, and has two holder lateral surface parts 22 that are coupled to each other. In the two holder lateral surface parts 22, fixing inner surfaces 23 facing each other have guided parts 23a provided thereto.
Resumen de: US20260294651A1
A method for designing a functional prosthesis of customized hand, for patients amputated at trans-radial level, implemented with additive manufacturing technology. The method flow for designing and developing the devices consists of the following steps: i) kinematic analysis and 3D scan of the limb contralateral to the amputated one; ii) kinematic synthesis of the planar mechanism at one active degree of freedom (GdL), modular for each finger, and optimization of the same through a global performance index (GPI); iii) prototyping of the assembly of five fingers.
Resumen de: US20260295199A1
Disclosed is a light therapy device for managing body clock of a user. The light therapy device includes a mask unit, and an electronic processing device. The mask unit has a light emitting panel having a plurality of light emitting sources (LES), and a controller operably coupled to the light emitting panel for controlling operational characteristics of the LES. The electronic processing device is in operational communication with the controller, and includes a simulation module, which is adapted to receive one or more operating parameters from the user, and a profile corresponding to the user. The simulation module is further configured to process the operating parameters and the profile, and send the processed information to the controller for managing the body clock of the user. This allows a personalization of the light therapy being provided to the user.
Resumen de: US20260295904A1
0000 A system includes a mold of a dental arch of a patient. The mold includes teeth extending from a first distal end of the dental arch to a second distal end of the dental arch. An orthodontic aligner is to be formed over the teeth of the mold. The teeth of the mold are shaped to correspond to tooth-receiving cavities of the orthodontic aligner. The system further includes a pre-fabricated attachment. The pre-fabricated attachment and the mold are configured to removably engage with each other via one or more mold features of the mold and one or more attachment features of the pre-fabricated attachment.
Resumen de: US20260294316A1
0000 An apparatus includes an electrocardiograph device having first, second, and third, electrode assemblies with first, second, and third electrodes adapted to measure first, second, and third electrical signals of an individual, respectively. The apparatus further includes a processing device to: determine a Lead I from the first electrical signal and the second electrical signal; determine a Lead II from the second electrical signal and the third electrical signal; generate a Lead III using (Lead III=Lead II−Lead I); determine, using a machine learning model trained using measured twelve-lead ECG data, Leads aVR, aVL, aVF, V1, V2, V3, V4, V5, and V6 based on Lead I, Lead II, and Lead III; and provide Leads Lead I, Lead II, Lead III, aVR, aVL, aVF, V1, V2, V3, V4, V5, and V6 for display on a client device.
Resumen de: US20260295115A1
0000 The present invention relates to a method for producing a collagen and silk polypeptide composite structure. In addition, the present invention relates to a collagen and silk polypeptide composite structure and uses thereof.
Nº publicación: US20260294278A1 01/10/2026
Solicitante:
GOOGLE LLC [US]
Google LLC
Resumen de: US20260294278A1
A computer-implemented method for assessing a fall risk of a user is provided. The computer-implemented method includes obtaining data indicative of the user engaging in a fall risk activity. The computer-implemented method includes adjusting a fall detection threshold of a wearable computing device worn by the user based, at least in part, on the data indicative of the user engaging in the fall risk activity. The method includes providing a notification indicative of the user being at risk of falling due, at least in part, to the user engaging in the fall risk activity.