Alerta

一种负载胰岛素的复合纳米颗粒及其制备方法和应用

Resumen de: CN119909037A

本发明公开了一种负载胰岛素的复合纳米颗粒及其制备方法和应用，复合纳米颗粒具有核壳结构，核为L‑缬氨酸修饰的壳聚糖与胰岛素自组装形成的聚电解质络合物，壳为阴离子多糖；或者复合纳米颗粒具有多层核壳结构，核为苯硼酸修饰的明胶与胰岛素自组装形成的聚电解质络合物，外面形成两层壳：L‑缬氨酸修饰的壳聚糖、褐藻糖胶。本发明可作糖尿病治疗的口服给药和注射给药。

一种氟代脂质纳米颗粒及其制备方法和应用

Resumen de: CN119912352A

本发明提供了一种氟代脂质体及其制备方法和应用。这一系列结构新颖的高度氟化的可离子化的脂质分子制备方法具有合成简单、产率高的优点。本发明还提供了包含氟代可离子化脂质或复合离子化脂质的LNP，所述LNP粒径分散性好，对于核酸的包封率高，生物体内毒性较低，可以高效的递送核酸药物使其具有更好的进细胞效率、核酸的表达效率，并具有脾脏靶向性，在免疫治疗中具有重大的应用前景。

脂质化合物及其组合物

Resumen de: CN119912351A

本发明涉及一种脂质化合物及其组合物。具体而言，本发明涉及式(I)的脂质化合物，包含其的脂质纳米颗粒，及其制备方法和在药物递送中的用途。#imgabs0#

组合物、成像剂、用于获得数据、提供和开发PDT、开发疗法和材料、评估受试者、MRI成像和升级MRI的方法以及MRI系统

Resumen de: JP2024094323A

To provide innovative drugs, medical products and imaging agents.SOLUTION: Provided is a method of imaging a subject, comprising: (i) administering to the subject an imaging agent having a plurality of nanostructures, each of the nanostructures comprising a multi-armed PEG and one or more additives that interact with the multi-armed PEG, and the multi-armed PEG of each of the plurality of nanostructures is sufficient to provide a nuclear magnetic resonance image when scanned in step (ii); (ii) following step (i), performing an imaging scan of the subject, the imaging scan being a nuclear magnetic resonance scan; and (iii) providing a nuclear magnetic resonance image of the multi-armed PEG of the plurality of nanostructures.

一种蜂皇浆冻干粉的包衣方法及其产品、应用、养肝胶囊及其制备方法

Resumen de: CN119909038A

本发明属于药品技术领域，具体涉及一种蜂皇浆冻干粉的包衣方法及其产品、应用、养肝胶囊及其制备方法。所述蜂皇浆冻干粉的包衣方法，包括以下步骤：S1、将包衣材料溶解于溶剂中，得包衣液：S2、采用包衣液对蜂皇浆冻干粉进行包衣，得包衣蜂皇浆冻干粉；所述包衣材料包括羟丙甲纤维素、改性麦芽糊精和异麦芽酮糖醇。采用本发明提供的包衣蜂皇浆冻干粉制备得到的养肝胶囊在阴凉、常温和加速条件下的水分含量均合格，而且避免了蜂皇浆冻干粉含量的严重下降。

一种用于肺部疾病治疗的纳米颗粒及其制备方法与应用

Resumen de: CN119912435A

本发明公开了一种用于肺部疾病治疗的纳米颗粒及其制备方法与应用。本发明所提供的用于肺部疾病治疗的纳米颗粒包括纳米颗粒载体和核酸分子；所述纳米颗粒载体，其原料包括所述TM2和DOPE，两者的摩尔比为1:2。本发明提供的包载核酸的纳米颗粒能够高效地将核酸分子递送至肺部，下调致病蛋白表达；能够显著增加药物在肺部的沉积，有效保证了给药以后的效果，同时具有给药方式简便，无创伤，安全性高等优点，是一种具有高创新性的高效肺部沉积的一种方式，在肺部相关疾病治疗方面具有很好的应用前景。

柚皮素纳米粒在头孢噻呋长效制剂制备中的应用

Resumen de: CN119424347A

The invention discloses an application of naringenin nanoparticles in preparation of a ceftiofur long-acting preparation. The invention discloses naringenin (5, 7-dihydroxy-2 (4-hydroxyphenyl) chroman-4-ketone), which is a flavonoid substance. The naringenin nanoparticles are prepared, the naringenin nanoparticles are mixed with the ceftiofur for combined use, and it is found that the naringenin can effectively intervene in the pharmacokinetic process of the ceftiofur and significantly prolong the in-vivo half-life period of the ceftiofur, so that the in-vivo action time of the ceftiofur is prolonged, and the curative effect of the ceftiofur is improved. Moreover, the application method is simple, easy to operate, low in cost and suitable for large-scale popularization.

一种抗肿瘤的蜂毒肽组合物及其应用

Resumen de: CN119909158A

本发明涉及蜂毒肽，特别涉及一种抗肿瘤的蜂毒肽组合物及其应用；本发明所述抗肿瘤的蜂毒肽组合物由蜂毒肽和TPGS‑CA通过自组装和静电作用所构成。蜂毒肽与TPGS‑CA形成纳米药物后，首先能够降低蜂毒肽的溶血性，减少其副作用；其次，TPGS‑CA具有较强的负电性，可以逃避网状内皮系统的吞噬延长体内循环时间；最后纳米药物通过EPR效应到达治疗部位后，TPGS‑CA在微酸性环境中能够水解成TPGS和CA，能够进一步加强蜂毒肽的抗肿瘤效果，从而达到高效抗肿瘤的目的。

鞣花酸纳米颗粒在制备具无创深层皮肤药物递送功能的外用制剂中的应用

Resumen de: CN119909061A

本发明提供一种鞣花酸纳米颗粒，无需添加大量辅料与复杂制备工艺，即能解决其溶解度、透皮吸收性能、皮肤深层递送性能极低的问题。将其用于制备具美白、祛斑、抗氧化、抗衰老、清除自由基、祛皱、防晒、增强皮肤的弹性、减少色素沉积、保湿、抗菌、抗病毒、治疗脱发、治疗白发、皮肤去油脂、治疗黑色素瘤、疤痕修复、创面愈合功能中的一种或多种功效的药品、化妆品、日化用品中，显示出向皮肤深层渗透药物的作用，最深可直达及靶向皮肤筋膜层。深层递送性能的提升与溶解度显著增强相关，也与纳米化性质相关，显示鞣花酸纳米颗粒在外用制剂，尤其是皮内深层药物递送的外用制剂的开发前景，这种深层递送不依赖于微针等装置，是完全无创递送的方法。

一种抑制卵巢癌的组合物、纳米颗粒、制备方法和应用

Resumen de: CN119909081A

本发明属于纳米医学技术领域，具体涉及一种抑制卵巢癌的组合物、纳米颗粒、制备方法和应用，包括蟾毒它灵和尼拉帕利，所述蟾毒它灵和尼拉帕利的摩尔比为6.25‑12.5:5000‑10000，本发明能够提高卵巢癌的抑制效果。

装载NLRP3-sgRNA核酸序列靶向巨噬细胞的纳米颗粒及防治葡萄膜炎的应用

Resumen de: CN119909039A

本发明提供一种装载NLRP3‑sgRNA核酸序列靶向巨噬细胞的纳米颗粒及防治葡萄膜炎的应用。本发明负载具有特异启动子的NLRP3‑sgRNA质粒，制备纳米颗粒PLGA‑sgNLRP3，然后将巨噬细胞膜包被于PLGA‑sgNLRP3纳米颗粒表面，制备得到巨噬细胞膜包被的纳米颗粒MM/PLGA‑sgNLRP3。本发明能将PLGA‑sgNLRP3和MM/PLGA‑sgNLRP3招募至视网膜病变部位，从而增加药物在病变部位的积蓄，增强基因干预作用，实现高效内毒素诱导的葡萄膜炎病变部位靶向功能，不仅能够减轻视网膜损伤、炎症反应，防止视网膜屏障受损，且具有良好的生物安全性，副作用小，疗效高。

聚合物复合物纳米材料封装系统

Resumen de: AU2023342576A1

Generally, a polymer nanomaterial encapsulation system useful in the production of polymer encapsulated nanoparticles comprised of a hydrophobic nanoparticle encapsulated in the hydrophobic region of the polymer with the external hydrophilic region of the polymer ensuring water-solubility and affording a functional group which can be utilized for the production of nanoparticle conjugates. Specifically, particular embodiments include a polymer nanoparticle structure including one or more of: a quantum dot and/or a superparamagnetic iron oxide nanoparticle and/or an upconverting nanoparticle, encapsulated in polystyrene-b-polyethylene glycol amine for the production of antibody conjugates useful in the capture of cellular targets.

一种双穿膜肽修饰的含STING抑制剂特异靶向血管内皮的纳米粒子及其制备方法与应用

Resumen de: CN119909184A

本发明属于生物医药技术领域，具体涉及一种双穿膜肽修饰的含STING抑制剂特异靶向血管内皮的纳米粒子及其制备方法与应用。本发明将STING抑制剂包裹于脂质体中得到脂质体纳米药物，以脂质体作为药物载体能提高其水溶性及生物利用度；同时，利用细胞穿膜肽和靶向穿膜肽共同修饰脂质体纳米药物，两者协同提高穿膜性能，帮助药物穿透眼部屏障，靶向视网膜血管内皮细胞，增加药物的生物利用度。并且，所得纳米粒子是以液态的形式存在，能够直接将其作为滴眼液用于治疗视网膜病变的眼睛，这样便捷、无创的眼部疾病治疗方式，能够更好地造福视网膜疾病患者，减少患者视网膜血管新生，有利于疾病的治疗和预后。

一种RSV抗原、核酸、表达元件、药物组合物及其应用

Resumen de: CN119912537A

本发明公开了一种RSV抗原、核酸、表达元件、药物组合物及其应用。所述RSV抗原为在SEQ ID NO:1的基础上包含突变A102C和S362C。所述RSV抗原具有比现有技术RSV更强的免疫原性，可以取得较高的中和抗体滴度，具有更高的保护效力。

一种基于不饱和脂肪酸的铁死亡调节纳米粒的制备方法及其应用

Resumen de: CN119909036A

一种基于不饱和脂肪酸的铁死亡调节纳米粒的制备方法，该脂质纳米粒由模型药、单不饱和脂肪酸、不同PEG分子量的磷脂聚乙二醇偶联物复合制成，方法是：将模型药、单不饱和脂肪酸与不同PEG分子量的磷脂聚乙二醇偶联物混合，然后溶解于乙醇中，超声混匀，滴入去离子水中，搅拌、旋蒸，除去甲醇和乙醇，离心，除上清液，干燥，即得；原料丰富，制备方法简单，易生产，产品质量好，性质稳定，能通过将多酚类药物有效递送至胰腺炎症部位，极大提高药物生物利用度以及胰腺炎症靶向能力，抑制胰岛β细胞的铁死亡来发挥治疗糖尿病的作用，是治疗糖尿病和胰腺炎药物上的一大创新，社会和经济效益巨大。

用于ECT成像和放射增敏治疗的诊疗一体双模态纳米颗粒及其制备方法和用途

Resumen de: CN119909206A

本发明公开一种用于ECT成像和放射增敏治疗的诊疗一体双模态纳米颗粒及其制备方法和用途，属于肿瘤诊疗药物技术领域。所述纳米颗粒由小尺寸铪‑没食子酸纳米颗粒标记可检测标记物得到；所述小尺寸铪‑没食子酸纳米颗粒由聚乙烯吡咯烷酮、四氯化铪与没食子酸通过配位组装形成。本发明提供的双模态纳米颗粒可同时用于ECT成像和放射增敏治疗，具有良好的生物安全性和优异的放疗增敏性能，在体内具有很好的代谢特性，克服常规纳米颗粒会在体内滞留的缺陷。

一种基于糖链修饰与相变材料的长效稳定重组RSV疫苗

Resumen de: CN119909163A

本发明涉及生物医药技术领域，公开了一种基于糖链修饰与相变材料的长效稳定重组RSV疫苗，所述疫苗包括以下质量份数的组分：动态糖链修饰的RSV F蛋白：1份；多级相变材料：3～5份，所述多级相变材料由聚乙二醇‑硬脂酸酯和月桂酸‑胆固醇复合物组成，其中聚乙二醇‑硬脂酸酯与月桂酸‑胆固醇的质量比为2～3:1；TLR9激动剂：0.05～0.15份；STING激动剂：0.02～0.08份；两亲性嵌段共聚物PLGA‑PEG‑PLL：0.5～1.5份。本发明解决了传统疫苗易失活、靶向性差及免疫原性不足的问题，适用于病毒性感染疾病的预防与治疗，具备规模化生产的应用潜力。

一种共负载黑色素茶多酚-镁的Janus微球及其制备方法与应用

Resumen de: CN119909021A

本发明公开了一种共负载黑色素茶多酚‑镁的Janus微球及其制备方法与应用，利用茶多酚和镁离子在碱性条件下络合形成纳米颗粒以及利用强碱溶解头发中的角蛋白获得黑色素纳米颗粒，将二者分别与甲基丙烯酰胶原混合配制成溶液作为流动相，以植物油作为分散相溶液，在微流控装置中，双通道流动相同轴共流，分散相流体利用流动剪切力将流动相分散为单分散液滴，液滴在紫外激光照射下固化形成共负载黑色素/茶多酚‑镁的Janus微球。本发明借助微流控技术，实现共负载黑色素/茶多酚‑镁的Janus微球的高均一性制备，可以实现协同抗氧化和抗菌治疗，可应用于各种具有抗氧化和抗菌需求的生物医学应用，如促进糖尿病创面、细菌感染性创面等的愈合。

一种纳米自组装体颗粒的制备及用于黑色素瘤靶向成像和光热治疗

Resumen de: CN119909035A

本发明公开了一种用于黑色素瘤靶向成像和光热治疗的自组装纳米颗粒，旨在解决现有光热治疗黑色素瘤方法中靶向性不强、光热效率低以及生物相容性差的问题。本发明设计了一种基于特定多肽(SA‑7)、芳香氨基酸(FF)和卟啉(TPP)的自组装纳米颗粒。通过自组装形成的纳米颗粒能够高效靶向黑色素瘤细胞，在638nm激光照射下产生强效的光热效应。同时，该纳米颗粒具有良好的生物相容性和代谢性能，可用于黑色素瘤的精准成像和治疗。

IONIZABLE LIPIDS AND IONIZABLE LIPID NANOPARTICLES

Resumen de: WO2025088570A1

A compound having the following structure of Formula (I) or a stereoisomer of the compound, tautomer of the compound, pharmaceutically acceptable salt thereof, wherein A1, A2, A3, R1a, R1b, R2a, R2b, m1, m2, m3, and X are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

COMPOSITIONS AND METHODS FOR TARGETING LIPID NANOPARTICLES

Resumen de: WO2025085950A1

The present invention is directed to lipid-based nanoparticles (e.g. lipid nanoparticles), formulations containing lipid-based nanoparticles and methods of treating diseases or conditions with said lipid-based nanoparticles and formulations thereof. The present invention provides a lipid-based nanoparticle comprising (a) an active agent, and (b) a plurality of capture binding domains displayed on the outer surface of the nanoparticle, wherein each capture binding domain is linked to the lipid-based nanoparticle through a site-specific linkage such that each capture binding domain is displayed in substantially the same orientation and capable of capturing a targeting moiety in an orientation that allows the targeting moiety to interact with its target. The present invention also provides a lipid-based nanoparticle comprising (a) an active agent, and (b) a plurality of targeting molecules displayed on the outer surface of the nanoparticle, wherein each targeting molecule is linked to the lipid-based nanoparticle through a site-specific linkage such that each targeting molecule is displayed in substantially the same orientation and capable of binding to a target on a cell surface.

METHODS FOR THE COUPLING OF DI(ALKYL)AMINES TO POLYPEPTIDES

Resumen de: WO2025088192A1

The present invention provides for inventive means and methods for the coupling of di(alkyl)amines to polypeptides or peptides capable of forming a random coil conformation. The present invention further provides inventive compounds produced by the herein detailed methods, wherein said compounds are characterized by formula (I): A-B-bC-D. Said compounds comprise a polypeptide/peptide capable of forming a random coil conformation, an N-terminal protecting group, a di(alkyl)amino group, and optionally a linker. Furthermore, the present invention provides lipid nanoparticles comprising said compounds characterized by formula (I) as well as means and methods for the production of said lipid nanoparticles. Formulations comprising the inventive compounds and/or the lipid nanoparticles of the present invention are also provided. Further, the present invention also relates to uses of the inventive compounds, the lipid nanoparticles, and/or the formulations disclosed herein.

COMPOSITIONS COMPRISING STEROL-AMINO-PHOSPHATE COMPOUNDS AND METHODS OF MAKING AND USE THEREOF

Resumen de: US2025135007A1

Disclosed herein are compositions comprising sterol-amino-phosphate compounds and methods of making and use thereof. Also disclosed herein are methods of making and methods of use of the compounds, compositions, and/or lipid particles disclosed herein. For example, the compounds and compositions are useful for treating a disease or disorder in humans and in animals. In some examples, the subject is a human male and the disease or disorder comprises male infertility.

Bioactive mitochondria encapsulated in a metal organic framework

Resumen de: US2025134925A1

According to an example aspect of the present invention, there is provided isolated bioactive mitochondria coated with a layer of Metal Organic Framework (MOF) and a method for intracellular delivery and release of said coated bioactive mitochondria in cells. The invention also provides a method for maintaining bioactivity and for increasing storage time of bioactive mitochondria by using MOF encapsulation.

miR-141-3p MODULATORS AND USES THEREOF

Nº publicación: US2025136985A1 01/05/2025

Solicitante:

UNIV OF CONNECTICUT [US]
University of Connecticut

Resumen de: US2025136985A1

Disclosed herein is a pharmaceutically effective composition comprising at least one of a phosphorothioate (PS)-based anti-miR-141-3p oligonucleotide; a peptide nucleic acid (PNA)-based anti-miR-141-3p oligonucleotide; and/or a gamma-peptide nucleic acid (γ-PNA)-based anti-miR-141-3p oligonucleotide; where at least one of the foregoing oligonucleotides is encapsulated in a biocompatible nanoparticle.