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LastUpdate Última actualización 14/03/2026 [06:52:00]
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Solicitudes publicadas en los últimos 15 días / Applications published in the last 15 days
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COMPOSITIONS AND METHODS FOR TREATING VENOUS BLOOD CLOTS

NºPublicación:  US20260069664A1 12/03/2026
Solicitante: 
THE UNIV OF NORTH CAROLINA AT CHAPEL HILL [US]
NEW YORK UNIV [US]
The University of North Carolina at Chapel Hill,
NEW YORK UNIVERSITY
US_20260069664_PA

Resumen de: US20260069664A1

Therapeutic compositions for treating a subject, the compositions including a polymeric nanoparticle, an active agent encapsulated within the polymeric nanoparticle, and a delivery vehicle for targeted delivery of the polymeric nanoparticle and encapsulated agent to a target tissue in the subject. The therapeutic compositions can be designed for targeting the destruction of a Nuclei neutrophil extracellular trap (NET) in a venous thrombus in a subject. The active agent can be an enzyme, including deoxyribonuclease 1 (DNase 1) enzyme. Methods of treating a subject using the therapeutic compositions are provided, including methods of treating venous thrombus, deep vein thrombosis, or a related blood clotting disease and/or condition.

COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS

NºPublicación:  US20260069549A1 12/03/2026
Solicitante: 
MODERNATX INC [US]
ModernaTX, Inc
US_20260069549_A1

Resumen de: US20260069549A1

The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

NUCLEIC ACID VACCINES ENCAPSULATED WITH NANOALUMINOSILICATE AGAINST MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS (MERS-CoV)

NºPublicación:  US20260069675A1 12/03/2026
Solicitante: 
IMAM ABDULRAHMAN BIN FAISAL UNIV [SA]
Imam Abdulrahman Bin Faisal University
US_20260069675_A1

Resumen de: US20260069675A1

A MERS-CoV vaccine with nucleic acid sequences having at least 90% identity to the spike gene of a MERS-CoV strain as a preventive measure against MERS-CoV infections is described. The nucleic acid sequences may include plasmid DNA (pDNA) or messenger RNA (mRNA) that are encapsulated by aluminosilicates. The aluminosilicates may be functionalized with aminopropyltrimethoxysilanes.

CATIONIC LIPIDS AND PREPARATION METHOD THEREOF

NºPublicación:  US20260069542A1 12/03/2026
Solicitante: 
RIBOX THERAPEUTICS HK LTD [CN]
RiboX Therapeutics HK Limited
US_20260069542_PA

Resumen de: US20260069542A1

The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids.

COMPOSITIONS AND METHODS FOR THE DELIVERY OF ACTIVE AGENTS INCLUDING NUCLEIC ACIDS

NºPublicación:  US20260069541A1 12/03/2026
Solicitante: 
OHIO STATE INNOVATION FOUND [US]
THE WHITEOAK GROUP INC [US]
Ohio State Innovation Foundation,
THE WHITEOAK GROUP, INC
US_20260069541_PA

Resumen de: US20260069541A1

Disclosed herein are lipid nanoparticles for the delivery of active agents, including nucleic acids, as well as methods of making using thereof.

LIPIDOID COMPOUNDS AND RELATED COMPOSITIONS AND USES

NºPublicación:  US20260069539A1 12/03/2026
Solicitante: 
POSEIDA THERAPEUTICS INC [US]
Poseida Therapeutics, Inc
US_20260069539_PA

Resumen de: US20260069539A1

Compositions comprising lipidoid compounds, methods of preparing such compositions, and the use of these compositions in gene delivery applications are disclosed.

CXCR4 ANTAGONIST LOADED LIPOSOMES AND SILICASOMES

NºPublicación:  US20260069538A1 12/03/2026
Solicitante: 
THE REGENTS OF THE UNIV OF CALIFORNIA [US]
The Regents of the University of California
US_20260069538_PA

Resumen de: US20260069538A1

In various embodiments drug delivery vehicles and uses thereof are provided. In certain embodiments the drug delivery vehicles comprise: 1) a silicasome comprising a mesoporous silica nanoparticle coated with a lipid bilayer and further comprising a CXCR4 antagonist; or 2) a liposome comprising a lipid bilayer comprising where said liposome further comprises a CXCR4 antagonist. In certain embodiments the CXCR4 antagonists are selected from the group consisting of AMD3100, AMD3465, and AMD070.

POLYNUCLEOTIDES ENCODING CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR FOR THE TREATMENT OF CYSTIC FIBROSIS

NºPublicación:  EP4704816A1 11/03/2026
Solicitante: 
MODERNATX INC [US]
ModernaTX, Inc
WO_2024229321_PA

Resumen de: WO2024229321A1

This disclosure relates to delivery vehicles comprising payload molecules, e.g., mRNA for the treatment of cystic fibrosis (CF). Nucleic acid therapeutics (e.g., mRNAs) when administered in vivo encode cystic fibrosis transmembrane conductance regulator (CFTR). Nucleic acid therapeutics (e.g., mRNAs) of the disclosure increase and/or restore deficient levels of CFTR expression and/or activity in subjects.

TREATMENTS COMPRISING AN MTOR INHIBITOR NANOPARTICLE COMPOSITION

NºPublicación:  EP4704842A1 11/03/2026
Solicitante: 
AADI BIOSCIENCE INC [US]
Aadi Bioscience, Inc
WO_2024228964_A1

Resumen de: WO2024228964A1

The present application, in certain aspects, pertains to methods and compositions for the treatment of cancers, such as undifferentiated pleomorphic sarcoma or leiomyosarcoma, using : (a) a composition comprising nanoparticles comprising an mTOR inhibitor (such as a limus drug, e.g, sirolimus or a derivative thereof) and an albumin; and, optionally, (b) an anti-PD-1 antibody.

STABLE POLYMER-LIPID NANOPARTICLE FOR DRUG BINDING AND DELIVERY, ESPECIALLY WITH ANTICANCER PROPERTIES, AND A METHOD FOR PRODUCING STABLE POLYMER-LIPID NANOPARTICLES CARRYING DRUGS, ESPECIALLY WITH ANTICANCER PROPERTIES

NºPublicación:  EP4704817A1 11/03/2026
Solicitante: 
BS BIOTECHNA SPOLKA AKCYJNA [PL]
BS Biotechna Spolka Akcyjna
CN_121487725_PA

Resumen de: WO2024228632A1

The description of the invention discloses a stable polymer-lipid nanoparticle for drug binding and delivery comprising a core containing polylactic-co-glycolic acid (PLGA) and polyvinyl alcohol (PVA) and a core envelope containing a mixture of lipids: 1,2-dipalmitoyl-sn-glycero-3- phosphocholine (DDPC), cholesterol and the ammonium salt of 1,2- distearoyl-sn-glycero-3-phosphoethanolamine-N -amino(polyethylene glycol)-2000 (DSPE-PEG(2000)NH2 and a method for producing such particles.

A PHARMACEUTICAL COMPOSITION COMPRISING 17-AAG AND STAUROSPORINE FOR USE IN THE PREVENTION OR TREATMENT OF CANCER AND DISEASES RESULTING FROM EXCESSIVE CELL PROLIFERATION AND A POLYMER- LIPID NANOPARTICLE CONTAINING THE COMPOSITION

NºPublicación:  EP4704827A1 11/03/2026
Solicitante: 
BS BIOTECHNA SPOLKA AKCYJNA [PL]
BS Biotechna Spolka Akcyjna
CN_121419768_PA

Resumen de: WO2024228630A1

The description of the invention discloses a composition comprising 17- AAG and staurosporine for use in the treatment of melanoma, non-small cell lung cancer, pancreatic cancer, mammary gland tumours or gliomas, and a stable polymer-lipid nanoparticle for drug binding and delivery, consisting of a core containing polylactic-co-glycolic acid (PLGA) and polyvinyl alcohol (PVA) and a core envelope containing a mixture of lipids: 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DDPC), cholesterol and the ammonium salt 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N - amino(polyethylene glycol)-2000 (DSPE-PEG(2000)NH2J.

SARS-COV-2 VACCINE COMPOSITIONS

NºPublicación:  EP4704893A2 11/03/2026
Solicitante: 
NOVAVAX INC [US]
Novavax, Inc
CN_121511094_PA

Resumen de: AU2024263334A1

Disclosed herein are coronavirus (CoV) Spike (S) polypeptides, including naturally and non-naturally occurring polypeptides, and nanoparticles and immunogenic compositions comprising the same, which are useful for stimulating immune responses against various SARS-CoV-2 strains. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.

LIPID NANOPARTICLE (LNP) FORMULATIONS

NºPublicación:  EP4704855A1 11/03/2026
Solicitante: 
SALIOGEN THERAPEUTICS INC [US]
Saliogen Therapeutics, Inc
WO_2024226779_A1

Resumen de: WO2024226779A1

The present disclosure describes lipid nanoparticle (LNP) compositions and uses thereof, e.g. for treating ocular-related disorders or diseases.

NANOPARTICLE COMPOSITION FOR OXYGEN DELIVERY

NºPublicación:  EP4704819A1 11/03/2026
Solicitante: 
SWAZA INC [US]
Swaza Inc
CN_121443280_PA

Resumen de: AU2024260092A1

The present disclosure in some aspects relates generally to nanoparticle compositions for oxygen delivery, method of use thereof, and method of preparation thereof. The present disclosure in some aspects relates generally to topical formulations capable of delivering oxygen to a tissue and methods of their use for treating diseases, such as hypoxemia.

ARTIFICIAL VIRUS CAPSID

NºPublicación:  EP4707386A1 11/03/2026
Solicitante: 
AGC INC [JP]
UNIV TOKYO [JP]
NAT UNIV CORP TOTTORI UNIV [JP]
AGC INC,
The University of Tokyo,
National University Corporation Tottori University
EP_4707386_A1

Resumen de: EP4707386A1

The present invention provides an artificial viral capsid modified with a compound containing a fluorine atom. The artificial viral capsid is formed by self-assembly of multiple subunits, wherein the subunit comprises a β-annulus peptide of tomato bushy stunt virus, a group derived from a fluorine-containing compound, and a divalent linking group that links the β-annulus peptide to the group derived from a fluorine-containing compound; and the divalent linking group is linked to a C-terminus of the β-annulus peptide.

PHARMACEUTICAL COMPOSITION COMPRISING TELOMERASE ACTIVATOR AND NANOPARTICLES FOR DRUG DELIVERY, AND COMPOSITION CONTAINING SAME FOR PREVENTION, ALLEVIATION, OR TREATMENT OF HAIR LOSS

NºPublicación:  EP4706660A1 11/03/2026
Solicitante: 
ARIBIO CO LTD [KR]
BIOCHEMGEN INC [KR]
Aribio Co., Ltd,
Biochemgen Inc
EP_4706660_PA

Resumen de: EP4706660A1

The present invention relates to a pharmaceutical composition comprising a telomerase activator and nanoparticles for drug delivery and a composition containing same for the prevention, alleviation, or treatment of hair loss. More specifically, the present invention relates to a composition effective for promoting the regeneration and growth of hair follicles, the composition being a nanoliposome, nano-liposome, nano-silica particle, or nano-bubble composition in which drugs such as the plant extract component TA-65 and a derivative thereof that increase telomerase activity, and the telomerase activating compound GPC and a derivative thereof are encapsulated

RECONSTITUTED HIGH-DENSITY LIPOPROTEIN NANOPARTICLES COMPRISING CHOLESTEROL

NºPublicación:  EP4706644A1 11/03/2026
Solicitante: 
MEPSGEN CO LTD [KR]
Mepsgen Co., Ltd
EP_4706644_PA

Resumen de: EP4706644A1

The present invention relates to: reconstituted high-density lipoprotein nanoparticles comprising cholesterol; and a composition for preventing or treating Alzheimer's disease and cancer, the composition comprising the nanoparticles. Specifically, the reconstituted high-density lipoprotein nanoparticles comprising cholesterol according to the present invention have an excellent cell influx rate and promote cholesterol efflux from cells, thus having a cancer cell killing effect, and can therefore be used for preventing or treating cancer.

PEGYLATED RECONSTITUTED HIGH-DENSITY LIPOPROTEIN NANOPARTICLES

NºPublicación:  EP4706645A1 11/03/2026
Solicitante: 
MEPSGEN CO LTD [KR]
Mepsgen Co., Ltd
EP_4706645_PA

Resumen de: EP4706645A1

The present invention relates to PEGylated reconstituted high-density lipoprotein nanoparticles having the effect of preventing or treating neurodegenerative diseases. Specifically, the present invention relates to nanoparticles and a method for producing the same, a phospholipid layer of the produced nanoparticles being protected by PEG due to PEG-lipid or a derivative thereof being included in the process of preparing a fluid comprising a hydrophobic material and a fluid comprising a hydrophilic material. The PEGylated nanoparticles have the ability to avoid the rejection mechanism of the immune response in the body while maintaining the existing transport ability across the blood-brain barrier, thereby having excellent stability and exhibiting long-term pharmacological effect due to high circulation ability in the body, and thus can be effectively utilized as a drug or a drug carrier.

CORTICOSTEROID NANOSUSPENSIONS AND USES THEREOF

NºPublicación:  EP4704852A2 11/03/2026
Solicitante: 
AIMMAX THERAPEUTICS INC [US]
Aimmax Therapeutics, Inc
KR_20260005253_PA

Resumen de: MX2025013065A

Suspension formulations of nanoparticles of clobetasol propionate are described. The suspensions can be used therapeutically to treat skin and ocular burns; to enhance wound healing; to prevent or reduce hypertrophic scarring/keloids; to treat allergic rhinitis/sinusitis, asthma, inner ear disorders including hearing loss, tinnitus, or vertigo, tenosynovitis, tendinitis, enthesitis or arthritis.

A PROIMMUNOTOXIN THERAPEUTIC NANOPLATFORM AGAINST CANCER

NºPublicación:  EP4704982A2 11/03/2026
Solicitante: 
UNIV CALIFORNIA [US]
The Regents of the University of California
WO_2024229147_A2

Resumen de: WO2024229147A2

Aspects of the disclosure relate to compositions comprising encapsulated immunotoxins and methods for using the encapsulated immunotoxins. The encapsulated immunotoxins may be capable of reaching otherwise difficult to target tissues, such as the brain, and may resist denaturation and degradation prior to reaching the targeted tissue.

PHYTIC ACID-BASED TERNARY COMPLEX BIONIC NANO MATERIAL, AND PREPARATION METHOD AND USE THEREOF

NºPublicación:  EP4706690A1 11/03/2026
Solicitante: 
THE SECOND HOSPITAL OF TIAN JIN MEDICAL UNIV [CN]
The Second Hospital of Tian Jin Medical University
EP_4706690_PA

Resumen de: EP4706690A1

The present application relates to the field of biological medicines, in particular to a phytic acid-based ternary complex bionic nano material. The ternary complex bionic nano material is composed of phytic acid, metal ions and a protein/polypeptide. The ternary complex is formed by connecting the protein/polypeptide with phytic acid using metal cations as a cation bridge. According to the application, the phytic acid ternary complex having different protein/polypeptide groups is synthesized by using various metal ions as bridges. A novel nano diagnosis and treatment probe having high biocompatibility is constructed, which can be reassembled and gathered for a long time at a tumor part, and has coordination-loaded imaging/therapeutic metal ions. The functions of long-acting tumor imaging, treatment or integrated diagnosis and treatment can be achieved, and the solution can be expected to be used as a novel bionic nano material in the field of biomedicine. In addition, the preparation process of the nano material is simple, and industrial production is easy to implement.

DRUG FOR GENETIC MODIFICATION, DRUG DELIVERY METHOD, AND DRUG DELIVERY CARRIER

NºPublicación:  EP4706637A1 11/03/2026
Solicitante: 
TOSHIBA KK [JP]
UNIV TOKYO [JP]
KABUSHIKI KAISHA TOSHIBA,
The University of Tokyo
EP_4706637_PA

Resumen de: EP4706637A1

According to one arrangement, a drug(1) for genetic modification according to an arrangement is a drug for performing genome editing on a gene in a hematopoietic stem cell. The drug for genetic modification contains a genome editing molecule(2) and a lipid nanoparticle(3) encapsulating the genome editing molecule. The lipid nanoparticle includes a lipid membrane(30) having a lumen. The lipid composition contains at least a first lipid (FFT-10) and a second lipid (FFT-20) in the lipid composition. The amount of the second lipid is larger than that of the first lipid, the total amount of the first lipid and the second lipid is 40 mol% or less, and the total amount of the cationic lipid is 60 mol% or less.

LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS

NºPublicación:  EP4705275A1 11/03/2026
Solicitante: 
ACUITAS THERAPEUTICS INC [CA]
Acuitas Therapeutics, Inc
KR_20260009860_A

Resumen de: MX2025013218A

Compounds are provided having the following Structure (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R<sup>1</sup>, R<sup>1</sup>, L<sup>1</sup>, L<sup>2</sup>, L<sup>2a</sup>, L<sup>2b</sup>, and A are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

一种环状RNA用于制备核酸药物的应用

NºPublicación:  CN121622725A 10/03/2026
Solicitante: 
中国药科大学
CN_121622725_PA

Resumen de: CN121622725A

本发明涉及一种环状RNA用于制备核酸药物的应用。本发明经实验研究证实,环状 RNA circPde5a 可用于制备长效减肥降糖核酸药物;将 circPde5a 递送至靶组织(如胰岛组织、白色脂肪组织)后,可通过调控靶组织代谢相关通路,实现减肥与降糖的双重效果。同时,该 circPde5a 还可与现有治疗手段协同使用。

一种脂质体纳米颗粒及其制备方法和应用

Nº publicación: CN121622615A 10/03/2026

Solicitante:

国家纳米科学中心

CN_121622615_PA

Resumen de: CN121622615A

本发明属于生物技术领域,公开了一种脂质体纳米颗粒及其制备方法和应用。本发明提供的脂质体纳米颗粒的制备方法中,首先通过特定粒径的金属纳米颗粒与RNA进行共孵育,接着再取该水相溶液与包括脂质体组合物的有机相溶液进行混合,以形成具有NPs‑RNA复合内核以及脂质体外壳的核壳结构的脂质体纳米颗粒,该脂质体纳米颗粒在内体的生理条件下对于内体的膜结构具有优秀的破坏作用,能够高效地介导RNA的内体逃逸,具有良好的内体逃逸效率,以实现RNA至细胞质的高效递送,从而实现更好的治疗或免疫效果,在RNA药物和/或RNA疫苗的制备中具有巨大的应用潜力。

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