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92
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Última actualización
18/10/2025 [07:42:00]
Resultados 50 a 75 de 92
Resumen de: CN120484134A
The invention relates to the technical field of biology, in particular to hermetia illucens antibacterial peptide H3 fusion protein, a construction method and application. The novel hermetia illucens antibacterial peptide H3 fusion protein provided by the invention not only has the antibacterial activity of the antibacterial peptide, but also has the activity of glucoside hydrolase, can realize rapid visual monitoring of the activity of the antibacterial peptide, has an inhibition effect on escherichia coli, salmonella and staphylococcus aureus, and can be used for preparing the antibacterial peptide H3 fusion protein. In the fields of food, hygienic products, cosmetics, biopesticides, biological feed additives or natural food preservatives and the like, the method has a wide application prospect.
Resumen de: KR20250122779A
구현예의 수의학적 조성물은 가금류의 대장균 또는 살모넬라균에 의한 설사 증상의 치료 또는 완화용도를 갖는 것으로, 색도 L이 77 이하인 액상이고, 유효성분 및 항산화제를 포함하고, 상기 유효성분은 아프라마이신 또는 이의 염을 유효성분을 포함한다. 구현예의 수의학적 조성물은 조류의 대장균증 또는 추백리의 치료 또는 완화용으로 그 효과가 우수하다. 또, 구현예의 수의학적 조성물은 아프라마이신 또는 이의 염을 유효성분으로 포함하는 액상 조성물로 유효성분에 대한 조성물의 보관 안정성이 우수하고, 투여가 용이한 장점도 있다.
Resumen de: WO2025170306A1
The present invention relates to an antibacterial composition comprising, as an active ingredient, a plantaricin peptide derived from a Lactiplantibacillus plantarum KM2 strain, wherein the plantaricin peptide derived from the strain and a plantaricin peptide combination were found to have antimicrobial activity against at least one selected from the group consisting of Flavobacterium sp, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, and acromobacter xylosoxidans (Alcaligenese xylosoxidans), Salmonella enterica, <i />and Vibrio parahaemolyticus, and the plantaricin peptide and the plantaricin peptide combination were found to have antibacterial activity and a cell wall lysis effect against the Flavobacterium sp. strain, and accordingly, the plantaricin peptide derived from the Lactiplantibacillus plantarum KM2 strain and the plantaricin peptide combination are provided as antimicrobial agents.
Resumen de: WO2025170108A1
The present invention relates to identifying and engineering a tail spike protein gene from a genome of bacteriophage SFP10 infected with a Salmonella strain, purifying and producing a recombinant protein using mSFP10TSP, which is a recombinant protein formulation for detecting Salmonella enterica, EGFP-mSFP10TSP fused with a green fluorescent protein, and SiBD-mSFP10TSP fused with an SiBD, and thereby specifically detecting the Salmonella strain.
Resumen de: CN120464522A
The invention discloses bacillus subtilis capable of strongly inhibiting clostridium perfringens and relates to the technical field of microorganisms, the bacillus subtilis is preserved in China General Microbiological Culture Collection Center on November 25, 2024, the preservation number is CGMCC No.32783, the bacillus subtilis is classified and named as bacillus subtilis, and the bacillus subtilis is preserved in the China General Microbiological Culture Collection Center on November 25, 2024. The bacillus subtilis is bacillus subtilis which can produce surfactin well and has a strong inhibition effect on clostridium perfringens, and the bacillus subtilis also has a certain inhibition effect on large intestines, salmonella and staphylococcus aureus.
Resumen de: CN120459191A
The invention provides a novel application of a cordate houttuynia extract as a salmonella type III secretion system (T3SS) inhibitor. Through construction of a mouse infection model and in-vitro experiments, the extract is proved to be capable of remarkably reducing the bacterial load of infected mouse liver and spleen tissues, relieving tissue pathological damage and reducing inflammatory cell infiltration. Mechanism research shows that the Houttuynia cordata extract can down-regulate the expression of T3SS key virulence protein SipA in a dose-dependent manner, interfere the function of a secretion system, and further block the secretion and expression of virulence factors. The potential application of the herba houttuyniae extract in the aspect of resisting salmonella toxicity is disclosed for the first time, and a development strategy and a technical basis of a T3SS inhibitor derived from a natural product are provided.
Resumen de: KR20250121172A
E. coli O157:H7을 감염하는 두 종의 박테리오파지 SFP10과 PhiV10로부터 얻은 tail spike protein(TSP)를 엔지니어링 하여 항체를 사용하지 않고도 식품 내 E. coli O157:H7균을 신속하게 검출할 수 있는 방법 및 이의 방법으로 제작된 재조합 단백질이다.
Resumen de: CN120468246A
The invention provides a magnetic control type electrochemical biosensor of MWCNTs-MoS2 based on CRISPR (clustered regularly interspaced short palindromic repeats)/Cas12a as well as a preparation method and application of the magnetic control type electrochemical biosensor. The magnetic control type electrochemical biosensor comprises an aminated multi-walled carbon nanotube-molybdenum disulfide modified screen-printed carbon electrode, wherein a CRISPR-crRNA-Target DNA ternary complex and a ferroferric oxide-gold-single-stranded nucleotide probe are dropwise added on the surface of the screen-printed carbon electrode, and the probe is sheared after the reaction of the CRISPR-crRNA-Target DNA ternary complex and the ferroferric oxide-gold-single-stranded nucleotide probe; the magnetic control type electrochemical biosensor respectively shows wide linear response in the range of 4.6 * 10 < 1 >-4.6 * 10 < 7 > CFU/mL of staphylococcus aureus and 5.5 * 10 < 7 > CFU/mL of salmonella, the detection limit of the magnetic control type electrochemical biosensor to two pathogenic bacteria is as low as 2CFU/mL, and the magnetic control type electrochemical biosensor has good specificity to interfering bacteria, can be used for rapid detection of food safety and has good practicability.
Resumen de: CN120464525A
The invention discloses a bacillus cereus JBH-LY1 strain and an application of the bacillus cereus JBH-LY1 strain in aquaculture, and relates to the technical field of microorganisms. The bacillus cereus JBH-LY1 is preserved in the China General Microbiological Culture Collection Center on June 6, 2024, and the preservation number of the bacillus cereus JBH-LY1 is CCTCC (China Center for Type Culture Collection) NO: M 20241168. The bacillus cereus is natural, safe, acid-resistant, alkali-resistant and high-temperature-resistant, has strong capability of producing protease, amylase, lipase and cellulase, and has a bacteriostatic effect on escherichia coli, salmonella typhimurium, staphylococcus aureus and aeromonas hydrophila. The bacillus cereus is used in the aquaculture industry, can purify aquaculture water and reduce the content of nitrogen and phosphorus, and also can regulate intestinal flora balance of cultured animals, promote growth, improve disease resistance and increase culture benefits.
Resumen de: KR20250121896A
본 발명은 사람에서 세균성 식중독을 일으키는 주요 원인균인 S. Enteritidis 및 S. Typhimurium, 그리고 가금에서 폐사를 일으키는 가금티푸스 원인균인 S. Gallinarum에 대한 산란계에서의 효과적인 살모넬라균 감염 예방을 위한 최적의 예방 프로그램 확립을 위한 발병을 수행하였다. 약독화 생균 백신만을 접종한 경우와 3가 살모넬라 불활화 사균체 백신만을 단독 접종한 산란계 모두에서 폐사는 발생하지 않았지만, 내부 장기 및 맹장 그리고 총 배설강 등에서 도전감염 균주가 분리되었다. 하지만 시판 백신인 약독화 생균 백신인 SG9R을 1차로 피하 접종한 후, 3가 살모넬라 불활화 사균체 (살모넬라 엔터라이티디스, 살모넬라 타이피뮤리움, 살모넬라 갈리나룸 불활화 사균체) 백신으로 추가로 근육 접종할 경우에는 내부 장기 및 맹장과 총배설강 등지에서 도전감염 균주가 분리되지 않았다. 이를 통해 약독화 생균 백신 및 3가 살모넬라 불활화 사균체 백신을 단독으로 접종한 경우보다 약독화 생균 백신 접종 후, 3가 살모넬라 불활화 사균체 백신을 추가로 접종할 경우 산란계에서 주요 살모넬라균을 효과적으로 예방할 수 있음이 확인하였다.
Resumen de: CN120464710A
The invention discloses a screening culture medium and a preparation method and application thereof, the screening culture medium comprises a basic culture medium and additives, and the additives comprise amphotericin B, vancomycin, ox bile salt, sodium deoxycholate and No.3 bile salt. According to the screening culture medium provided by the invention, a special infectious microbe inhibitor is added on the basis of a trisaccharide iron culture medium, so that most gram-negative enterobacter, staphylococcus aureus and part of fungi except salmonella enteritis subspecies and shigella cannot grow; the interference of the infectious microbes on the detection of the salmonella enteritis subspecies and the shigella is avoided, so that the fluorescent probe can be applied to the detection of the salmonella enteritis subspecies and the shigella in a clinical anus swab, and the sensitivity of color development is improved.
Resumen de: CN120459124A
The invention discloses a novel application of rutin in preparation of a salmonella type III secretion system (T3SS) inhibitor. By constructing a salmonella mouse infection model, the rutin is proved to be capable of remarkably improving the survival rate of infected mice, reducing the bacterial load of liver and spleen target organs and effectively relieving the tissue damage of intestinal tracts, livers and spleens. In-vitro tests show that rutin does not affect the growth of bacteria, and the mechanism of the rutin playing a protection role is that the expression of a salmonella T3SS virulence factor is specifically inhibited, so that the pathogenicity of salmonella is weakened. The invention discloses a potential application of rutin as a salmonella T3SS inhibitor, and provides a theoretical basis for development of related anti-infective drugs.
Resumen de: CN120436313A
The invention provides a portulaca oleracea fermentation process, which utilizes lactobacillus plantarum BJ-M8 with carbohydrate amylase, glucosidase and cellulase production capacity to ferment portulaca oleracea, and promotes the conversion of macromolecular glycoside substances to small molecular aglycones. Metabonomics analysis shows that through fermentation treatment of the strain BJ-M8, the composition of alkaloids, phenolic acids, flavonoids and the like of purslane is effectively improved. Compared with the prior art, the target product calycosin is increased by 10 times, acacetin is increased by 7 times, kaempferol is increased by 4 times, apigenin is increased by 4 times, naringenin is increased by 3 times, dihydroferulic acid is increased by 177 times, dihydrocaffeic acid is increased by 27 times, and spinogenin is increased by 6 times. According to an in-vitro evaluation test, the inhibition effect of the fermented purslane on salmonella and escherichia coli is enhanced, the anti-inflammatory effect on LPS treated macrophage RAW264.7 and the oxidation resistance on Caco-2 cells are improved, and the application prospect in the aspect of functional product preparation is wide.
Resumen de: CN120442561A
The invention provides a cross-species lysis bacteriophage RDP-EC-20146 and application thereof, and belongs to the technical field of biology. The cross-species lysis bacteriophage is an escherichia coli bacteriophage, the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.45351, and the cross-species lysis bacteriophage is preserved in China General Microbiological Culture Collection Center on October 28, 2022. The cross-species lysis bacteriophage RDP-EC-20146 provided by the invention has the characteristics of high lysis activity and good physical and chemical factor tolerance; the method is not influenced by the drug resistance of bacteria, does not have the problems of drug residues and the like, and has very high use safety; in addition, when the bacteriophage RDP-EC-20146 provided by the invention is combined with 8 low-dose antibiotics for use, a remarkable bacteriostatic effect can be shown, and the bacteriophage RDP-EC-20146 has a good application prospect in the aspect of preventing and treating salmonella, escherichia coli, staphylococcus aureus and/or pseudomonas aeruginosa diseases.
Resumen de: CN120442560A
The invention relates to the technical field of salmonella bacteriophages, and in particular relates to a bacteriophage capable of splitting salmonella brassicae as well as a composition and application of the bacteriophage capable of splitting the salmonella brassicae. The bacteriophage is salmonella bacteriophage RDP-SA-22010, the preservation number of the bacteriophage is CGMCC (China General Microbiological Culture Collection Center) No.45274, and the bacteriophage is preserved in the China General Microbiological Culture Collection Center on September 21, 2022. The salmonella bacteriophage RDP-SA-22010 can also be used for cracking salmonella enteritidis, salmonella pullorum and salmonella kafenkii. The invention also relates to a composition, which comprises the salmonella bacteriophage RDP-SA-22010. The reagent or the kit comprises the composition. The invention also provides application of the salmonella bacteriophage RDP-SA-22010 to preparation of a biological bactericide, preparation of a medicine for treating diseases caused by salmonella and preparation of a feed additive. The salmonella bacteriophage RDP-SA-22010 disclosed by the invention provides a novel biological prevention and treatment means for the prevention and treatment of salmonella bulidan.
Resumen de: WO2025165867A1
Provided herein are compositions comprising in vivo succinate-producting microorganisms, e.g., Bacteroides and Prevotella species (preferably Bacteroides thetaiotaomicron (e.g., VPI 5482), Bacteroides vulgatus (e.g., NCTC 11154, Prevotella copri (e.g., DSM 18205)), Parabacteroides (e.g., Parabacteroides distasonis), and Bacilli (e.g. Lactobacillus animalis), and methods of use thereof in treating or reducing risk of developing an intestinal infection, optionally an infection with Campylobacter, Salmonella, E. coli, Shigella, Listeria monocytogenes, Vibrio, Enteropathogenic E. coli, Klebsiella, or Clostridioides difficile, or promoting expansion of colonic tuft cells, in a subject.
Resumen de: KR20250117498A
본 발명은 살모넬라 균 (Salmonella spp.) 검출용 조성물 및 이를 이용한 검출방법에 관한 것으로서, 보다 상세하게는 살모넬라 균 InvA 유전자 서열을 증폭하기 위한 프라이머 세트와 프로브에 관한 것으로, 식용 갈색거저리 내 유해균인 살모넬라 균을 특이적으로 검출 할 수 있다.
Resumen de: CN120420281A
The invention discloses florfenicol nano-liposome and a preparation method and application thereof, the florfenicol nano-liposome is prepared from soybean lecithin, florfenicol and cholesterol according to the mass ratio of (10-30): 4: 5, florfenicol, cholesterol and soybean lecithin are dissolved in an organic solvent, rotary evaporation is performed, water is added for dissolution, and then ultrasonication is performed to obtain the florfenicol nano-liposome. The average particle size of the florfenicol liposome prepared by the preparation method disclosed by the invention is 249.6 to 638.2 nm, the Zeta potential value of the florfenicol liposome is-13.7 to-46.3 mV, and the polydispersity coefficient of the florfenicol liposome is 0.22 to 0.86. The entrapment rate is 88.31%-92.94%, the drug loading capacity is 3.21%-6.29%, the minimum inhibitory concentration to a salmonella standard strain is 4 mu g/mL, and the minimum bactericidal concentration to the salmonella standard strain is 8 mu g/mL. The minimum inhibitory concentration of the salmonella drug-resistant strain is 8 mu g/mL, and the minimum bactericidal concentration of the salmonella drug-resistant strain is 34 mu g/mL.
Resumen de: CN120427903A
The invention discloses a colorimetric-fluorescent dual-signal salmonella detection method based on Ag-MoS2 nano-enzyme. The method is characterized by comprising the following steps: mixing a single strand S1, a single strand S2, a single strand S3, a single strand S4, a salmonella aptamer and cDNA (complementary deoxyribonucleic acid) to prepare a multivalent aptamer competitive probe solution; respectively dissolving a hairpin probe H1 and a hairpin probe H2 in PBS (Phosphate Buffer Solution); a step of preparing an Ag-MoS2 nano enzyme composite material; the method comprises the following steps: mixing and incubating a to-be-detected salmonella solution and a multivalent aptamer competitive probe, adding the Ag-MoS2 nano-enzyme composite material for performing CHA amplification reaction, then adding an H2O2 solution and a TMB solution for performing peroxidase catalytic reaction, respectively performing colorimetric method and fluorescence method detection, and calculating to obtain the salmonella concentration in the to-be-detected solution. The kit has the advantages of simplicity, rapidness, high sensitivity, strong specificity, high accuracy and real-time sterilization after detection.
Resumen de: CN120400375A
The invention discloses a double-target primer probe composition, application and a kit. The double-target primer probe composition comprises amplification primers and fluorescent probes of a salmonella invasion related gene InvA and an avian pathogenic escherichia coli aerobacin receptor gene IutA. The composition can be used for detecting pathogenic bacteria in poultry farms, and is high in sensitivity, good in specificity, reliable in result and free of cross interference among primers; the kit is suitable for a recombinase polymerase amplification technology, can be used for clinical diagnosis and epidemic condition monitoring of avian pathogenic escherichia coli and salmonella, and has excellent industrial application value.
Resumen de: CN120400125A
The invention discloses a method for rapidly extracting and enriching salmonella pullorum nucleic acid based on chitosan modified diatomite. The method comprises the following steps: (1) pretreating diatomite; (2) functional modification of chitosan; and (3) extracting salmonella pullorum nucleic acid. The chitosan-diatomite composite material disclosed by the invention is based on a synergistic mechanism of an electrostatic interaction micropore interception effect, the selectivity is improved by utilizing the cationic characteristic of chitosan, the chitosan is fixed on the surface of diatomite through glutaraldehyde crosslinking, the dissolution loss in an acid environment is avoided, the high specific surface area of the diatomite and the charge adsorption of the chitosan are combined, and the adsorption capacity of the diatomite is improved. A'physical interception + chemical bonding 'dual-mode enrichment mechanism is established, efficient capture of existing nucleic acid is achieved, qPCR detection sensitivity is remarkably improved, the bottleneck problem of a traditional nucleic acid extraction method in complex poultry samples is solved, and the method has the advantages of high detection rate, high anti-interference performance and operation convenience and is suitable for popularization and application. And reliable technical support is provided for rapid molecular diagnosis and epidemiological monitoring of the pullorum disease bacteria.
Resumen de: CN120400315A
The invention discloses a rapid detection method and a kit for salmonella typhimurium in a dairy product, and relates to the technical field of biological detection, the kit is provided with a primer group and a reagent, and the kit contains a positive reference substance and a negative reference substance; the detection method comprises the following steps: acquiring a sample, purifying genome DNA of the sample, carrying out PCR amplification by taking the purified genome DNA as a template to obtain a salmonella typhimurium fimY gene segment, purifying the salmonella typhimurium fimY gene segment, carrying out T-A ligation reaction, transformation and recovery, preparing a fluorescent quantitative PCR standard substance, preparing a dye-method real-time fluorescent quantitative PCR reaction system, and detecting the salmonella typhimurium fimY gene segment. Fluorescence signals are collected in real time, a Ct value is measured, a standard curve is drawn, the sample concentration is calculated, and qualitative and quantitative analysis is carried out. The method does not need to design a complex probe, the primer design is relatively simple, the detection accuracy and reliability are improved, the cost is reduced, and the detection efficiency is greatly improved.
Resumen de: CN120400005A
The invention discloses attenuated salmonella recombinant engineering bacteria for expressing TFPI-2 and IFN alpha as well as a preparation method and application of the attenuated salmonella recombinant engineering bacteria, and relates to the technical field of biology. The preparation method of the recombinant engineering bacterium comprises the following steps: sequentially connecting a secretory signal peptide coding gene, a TFPI-2 gene and an IFN alpha gene to obtain a connection product; connecting the connection product to an expression vector to obtain a recombinant plasmid; and transforming the recombinant plasmid into attenuated salmonella to obtain an attenuated salmonella recombinant engineering bacterium for expressing TFPI-2 and IFN alpha. The recombinant engineering bacterium can be colonized in a tumor tissue area, stably and continuously express and secrete TFPI-2 and IFN alpha, promotes tumor tissue immune cell infiltration, and shows good tumor treatment effect and tumor targeting.
Resumen de: CN120392738A
The invention discloses an application of bilobalide in preparation of a product for resisting salmonella typhimurium infection. The bilobalide takes salmonella typhimurium QseB protein as a target, has a good interference effect on an AI-2 quorum sensing signal of salmonella typhimurium and has good pharmacological activity, and particularly, the bilobalide has good pharmacological activity under the condition that the growth of salmonella typhimurium is not inhibited. The motility, biofilm formation and infection pathogenicity of salmonella typhimurium are obviously inhibited. The bilobalide does not influence the growth of salmonella typhimurium, directly acts on pathogenic factors, weakens the pathogenicity of bacteria from the source, does not generate selective pressure on salmonella typhimurium, and does not cause the generation of drug-resistant pathogenic bacteria. Therefore, the bilobalide has a good application prospect in the aspect of development of the salmonella typhimurium infection resisting medicine.
Nº publicación: CN120405121A 01/08/2025
Solicitante:
GUANGDONG UNIV OF TECHNOLOGY
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Resumen de: CN120405121A
The invention belongs to the technical field of biochemical analysis and detection, and particularly relates to a composite nanomaterial probe for detecting salmonella typhimurium, a preparation method of the composite nanomaterial probe and a dual-mode immunochromatography test strip. According to the present invention, the improved dual-mode reading is achieved by improving the signal label, the BrM (at) Os with the surface modified with the rabbit anti-salmonella typhimurium polyclonal antibody is adopted as the detection probe, and the fluorescence and catalytic colorimetric dual-mode immunochromatography test strip capable of detecting salmonella typhimurium is prepared; the immunochromatographic test strip can realize sensitive immunochromatographic analysis on salmonella typhimurium in both fluorescence and catalytic colorimetric modes.
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