Alerta

一种叶酸-邻苯二胺共掺杂碳量子点、大肠埃希氏菌O157:H7检测探针、检测试剂及应用

Resumen de: CN121471909A

本发明属于食品安全检测技术领域，具体涉及一种叶酸‑邻苯二胺共掺杂碳量子点、大肠埃希氏菌O157:H7检测探针、检测试剂及应用。叶酸‑邻苯二胺共掺杂碳量子点由叶酸和邻苯二胺加热反应制得。基于本发明的叶酸‑邻苯二胺共掺杂碳量子点的检测探针或检测试剂对大肠埃希氏菌O157:H7进行检测，检测限低、特异性优异，实用性强。

一种用于检测大肠杆菌的双模态生物传感器检测试剂盒及制备方法

Resumen de: CN121476591A

本发明具体涉及一种用于检测大肠杆菌的双模态生物传感器检测试剂盒及制备方法，属于食品安全检测技术领域。双模态生物传感器检测试剂盒由网状靶向磁珠和生物传感器检测试剂组成；生物传感器检测试剂为适配体修饰的铜金属掺杂碳点溶液，适配体为氨基化适配体。本发明的双模态传感器提供的双信号可以互相校准，避免单信号输出的偶然性误差，还可根据不同的场景选择优势检测模态；以网状PGA结构为中间体包覆四氧化三铁磁珠，高负载的网状结构为识别元件提供更多结合位点进一步增强了磁分离技术的捕获效率；增强磁分离技术驱动的双金属靶向改性碳点在检测大肠杆菌O157:H7时具有良好的检测性能，在食品基质中捕获低浓度目标菌的效率可达90%以上。

一种阪崎克罗诺杆菌核酸适配体及其在制备生物传感器中的应用

Resumen de: CN121472232A

本发明涉及生物技术领域，具体公开了一种阪崎克罗诺杆菌核酸适配体及其在制备生物传感器中的应用。本发明针对阪崎克罗诺杆菌MipA蛋白设计了DNA序列如SEQ ID No:1所示的核酸适配体，5’端氨基修饰。该适配体可用于构建荧光淬灭型生物传感器，包括荧光探针（枸橼酸二铵、硫脲、正硅酸甲酯及二氧化铈合成荧光纳米粒子，第一适配体羧基修饰）和淬灭探针（柠檬酸还原金纳米粒子，第二适配体巯基修饰，SEQ ID No:2）。与传统方法相比，筛选效率显著提升，检测时间<1h，抗干扰强，亲和常数13.28nM，适用于婴幼儿食品快速监测，经济成本降低至少40%。

LIVER DISEASE TREATMENTS USING ATTENUATED STRAINS OF SALMONELLA TYPHIMURIUM

Resumen de: WO2026030756A2

The composition and methods of treatment disclosed or contemplated herein include compositions and methods of treatment for liver-related diseases. The overall treatment strategy would involve the identification of a target protein or receptor within the liver that is responsible for ongoing liver injury. The strain of orally administered Salmonella Typhimurium that colonizes the liver would be engineered to secrete a particular protein or nanobody that would stop and/or reverse the progressive hepatic disease

ANTI-ETEC ADHESIN PROTEIN ANTIBODIES AND METHODS OF USE

Resumen de: US20260035440A1

The invention provides anti-ETEC adhesin protein antibodies and methods of using the same.

A YEAST BIOMASS COMPOSITION AND USES THEREOF

Resumen de: WO2026027798A1

A yeast biomass composition is formed by culturing a strain of yeast in a substrate such as whey permeate to product a yeast broth, dewatering the broth to produce yeast biomass, and hydrolysing the yeast biomass. The yeast biomass composition finds utility as a feed additive for broiler chickens to reduce the adherence of pathogenic bacteria like Salmonella and E.coli to the gut wall of the chickens, thereby reducing intestinal stress and improving life daily weight gain in the chickens.

Monoclonal antibody combination for Brucella detection and application thereof

Resumen de: CN121449738A

The invention discloses a monoclonal antibody combination for Brucella detection and application thereof, and belongs to the technical field of immunodetection. The monoclonal antibody combination disclosed by the invention comprises a monoclonal antibody 15F4 and a monoclonal antibody 32H9. On the basis of the monoclonal antibody combination, a double-antibody sandwich ELISA detection method with 15F4 as a capture antibody and enzyme-labeled 32H9 as a detection antibody is established, and key parameters such as coating concentration, closing conditions, incubation and color development time and the like are optimized. The method has high specificity on brucella, and does not cross with common cross-reactive bacteria such as escherichia coli O: 157, salmonella and the like; the sensitivity is high, and the detection limit can reach 1 * 10 < 5 > CFU/mL; the repeatability is good, and the intra-batch and inter-batch variation coefficients are both smaller than 10%. The invention provides a core reagent and a reliable means for early, rapid and accurate diagnosis of brucellosis, and is suitable for on-site screening of clinical samples and animal epidemic diseases.

一种多功能纳米材料荧光-比色双模式食源性致病菌检测与杀灭方法及其系统

Resumen de: CN121454057A

本发明公开了一种多功能纳米材料荧光‑比色双模式食源性致病菌检测与杀灭方法及其系统。该方法利用具有纳米酶活性的金属有机框架材料（MIL‑53(Fe)）作为信号开关与发生器，联合荧光指示与光热杀菌单元的碳纳米点（CDs）共同构成了基础平台，利用适配体对纳米酶活性位点的掩蔽与目标菌触发下的竞争性释放为核心机制，激活比色与比率荧光双信号通道，实现自验证的高精度检测；并利用体系中的CDs作为光热元件，在检测后实现原位光热杀菌。通过更换适配体即可切换检测对象的“平台化”设计，展现了良好的通用性和应用前景，为食源性致病菌的检测与消除提供了灵敏、高效的新策略。

Recombinant salmonella choleraesuis nuclease regulation vector as well as construction method and application thereof

Resumen de: CN121450682A

The invention discloses a recombinant salmonella choleraesuis nuclease regulation vector as well as a construction method and application thereof. After oral administration, the recombinant salmonella choleraesuis nuclease regulatory vector rSC0140 enters host immune cells, c-di-AMP is released, a host STING pathway is activated, and a broad-spectrum antiviral effect can be achieved; the recombinant strain rSC0140 is proved to be capable of activating STING pathways in macrophages and mice, causing antiviral states of the macrophages and the mice and resisting challenge of various influenza viruses; the recombinant strain has broad-spectrum antiviral efficacy and is suitable for preventing and treating various virus diseases clinically.

Method of diagnosing migraine using oral microbiome

Nº publicación: KR20260015111A 02/02/2026

Solicitante:

UIF UNIV INDUSTRY FOUNDATION YONSEI UNIV [KR]
\uC5F0\uC138\uB300\uD559\uAD50 \uC0B0\uD559\uD611\uB825\uB2E8

Resumen de: KR20260015111A

본 개시는 편두통 진단을 위한 정보 제공 방법에 관한 것으로서, 보다 상세하게는 생물학적 시료에서 제멜라 헤몰리산스, 센티페다 페리오돈티, 카르디오박테리움 발바룸, 카토넬라 모르비 및 셀레노모나스 녹시아로 이루어진 군에서 선택된 적어도 하나의 박테리아의 상대적 풍부도를 측정하는 단계를 포함함으로써 환자의 통증 또는 거부감 없이 정확하고 신속한 편두통 진단을 가능하게 하는 방법에 관한 것이다.