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LastUpdate Última actualización 08/12/2025 [07:07:00]
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Engineered whole-cell vaccine as well as preparation method and application thereof

NºPublicación:  CN120605321A 09/09/2025
Solicitante: 
NANJING UNIV
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CN_120605321_PA

Resumen de: CN120605321A

The invention provides an engineered whole-cell vaccine as well as a preparation method and application thereof. The engineered cell comprises a tumor cell and attenuated salmonella loaded in the tumor cell. According to the engineered cell disclosed by the invention, the attenuated salmonella can activate an NF-kappa B pathway and drive macrophages in tumor cells to be reprogrammed from an immunosuppression phenotype M2 to an immunogenicity phenotype M1, and the reprogrammed M1 type macrophages can enhance presentation of specific tumor antigens in the tumor cells; therefore, the immune microenvironment of macrophages can be remodeled, the immune response to the melanoma is enhanced, and the prevention and treatment effects on postoperative recurrence and metastasis of the melanoma are further improved.

一种猪源细菌多糖-病毒蛋白结合疫苗及其制备方法和应用

Nº publicación: CN120605324A 09/09/2025

Solicitante:

杭州依思康医药科技有限公司浙江洪晟生物科技股份有限公司

CN_120605324_PA

Resumen de: CN120605324A

本发明涉及一种猪源细菌多糖‑病毒蛋白结合疫苗及其制备方法和应用,属于动物疫苗技术领域。该疫苗以猪源细菌多糖和病毒蛋白为原料,通过生物素‑亲和素体系偶联形成多糖‑病毒蛋白结合物;其中病毒蛋白选自猪瘟病毒E2蛋白、猪圆环病毒2型Cap蛋白、猪伪狂犬病毒gD蛋白等蛋白中的一种,猪源细菌多糖选自猪链球菌荚膜多糖、猪多杀性巴氏杆菌荚膜多糖等多糖中的一种。该疫苗能同时诱导机体产生针对猪源细菌荚膜多糖和病毒蛋白的高水平IgG抗体,实现对猪源细菌和病毒感染的协同免疫保护,具有广谱交叉免疫效果。

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