Alerta

COLLAGEN DROPLET-BASED 3D CELL SPHEROIDS AS 3D PRINTABLE BIO-INK

Resumen de: US20260108889A1

Described herein is microfluidic droplet generation device for producing multicellular collagen encapsulated spheroids. The multicellular collagen encapsulated spheroids can be used as bio-ink comprising multicellular collagen encapsulated spheroids and a scaffold which can be used to 3D bio-print in vivo-like 3D tumor models. When combined together the 3D multicellular collagen encapsulated spheroid generation platform is adjustable, can be used for high-throughput generation of 3D multicellular collagen encapsulated spheroids and 3D tumor models, and can be used to produce 3D multicellular collagen encapsulated spheroids and 3D tumor models at large scale.

INFUSION VOLUME DETECTION SYSTEM AND METHOD

Resumen de: US20260108673A1

A vision-enabled fluid flow rate detection system is disclosed. The system includes an image sensing device that images an infusion container supplying a fluid to an infusion pump and a pattern of markings associated with a surface of the container, and identifies a visual difference in the pattern from a default state of the pattern to determine a volume of fluid infused from the infusion container, and used to calculate a volume of fluid in the container and a flow rate of the fluid. When the amount of fluid, as determined by the vision system, differs from the amount reported by the pump, the pump's motor may be adjusted to correct the expected volume or flow rate, as needed. When a severe infusion inaccuracy is detected, an alarm or other indication may be provided, or the infusion terminated.

BIOPRINTING ROBOTIC SYSTEM, DEVICE, AND METHOD

Resumen de: US20260108314A1

A bioprinting robotic system comprises a robotic manipulator, a bioprinting instrument configured as an end effector of the robotic manipulator further configured to print bioink, a head mounted display (HMD), an optical tracking system, and a computing system communicatively connected to the robotic manipulator, bioprinting instrument, HMD and optical tracking system. A bioprinting instrument comprises a housing, a distance measurement sensor, a light source, 3D point cloud camera, and a co-axial nozzle positioned on a one degree of freedom (DoF) linear height control mechanism. A bioprinting method comprises providing the bioprinting robotic system above, obtaining a high-resolution volumetric geometry of an injury via the 3D point cloud camera, designing a desired 3D printing geometry and corresponding printing trajectories, calibrating and registering the bioprinting robotic system, displaying on the HMD the desired printing trajectory, and printing along the desired printing trajectory via a surgeon manipulating the bioprinting instrument.

USING BIOMARKER INFORMATION FOR HEART FAILURE RISK COMPUTATION

Resumen de: US20260108216A1

0000 Provided is a method, system and/or apparatus for determining prospective heart failure event risk. Acquired from a device memory are a heart failure patient's current and preceding risk assessment periods. Counting detected data observations in the current risk assessment period for a current risk assessment total amount and counting detected data observations in the preceding risk assessment period for a preceding risk assessment period total amount. Associating the current risk assessment and preceding risk assessment total amounts with a lookup table to acquire prospective risk of heart failure (HF) event for the preceding risk assessment period and the current risk assessment period. Employing weighted sums of the prospective risk of the HF event for the preceding risk assessment period and the current risk assessment period to calculate a weighted prospective risk of the HF event for a patient. Displaying on a graphical user interface the weighted prospective risk of the HF event for the patient.

SYSTEM FOR DISPLAYING MEDICAL MONITORING DATA

Resumen de: US20260108218A1

0000 A first medical device can receive a physiological parameter value from a second medical device. The second physiological parameter value may be formatted according to a protocol not used by the first medical device such that the first medical device is not able to process the second physiological parameter value to produce a displayable output value. The first medical device can pass the physiological parameter data from the first medical device to a separate translation module and receive translated parameter data from the translation module at the first medical device. The translated parameter data can be processed for display by the first medical device. The first medical device can output a value from the translated parameter data for display on the first medical device or an auxiliary device.

Method and System for Planning Implant Component Position

Resumen de: US20260111096A1

0000 A method for planning an orthopedic procedure including positioning a virtual implant component relative to a 3D volume of scan data of a patient using multiple 2D views of the scan data generated from the 3D volume at different view angles is disclosed. Positional information is developed using the generated 2D views with 3D positional information for the virtual implant component relative the 3D volume of scan data provided based on positional information developed relative to the 2D views.

SYSTEMS AND METHODS TO MEASURE, PREDICT AND OPTIMIZE BRAIN FUNCTION

Resumen de: US20260112487A1

Methods and apparatus for changing a brain state of a person from an initial brain state to a target brain state are described. The method includes receiving information characterizing the initial brain state, the information including a structural composition and a functional architecture of the brain, estimating based, at least in part, on the received information, a potential for the brain to change from the initial brain state to the target brain state, determining based, at least in part, on the received information and the estimated potential for the brain to change from the initial brain state to the target brain state, a non-invasive brain stimulation protocol, and controlling at least one non-invasive brain stimulation device to stimulate the brain according to the non-invasive brain stimulation protocol. The method also includes using brain information to inform the design of computational general artificial intelligence agents.

APPARATUSES, SYSTEMS, AND METHODS FOR BIOMARKER COLLECTION, BI-DIRECTIONAL PATIENT COMMUNICATION AND LONGITUDINAL PATIENT FOLLOW-UP

Resumen de: AU2026202565A1

Approaches for generating a set of biomarkers and generating a summary and one or more recommendations based, at least in part, upon the biomarkers are provided. Sensor data associated with a user may be received. The sensor data may be analyzed to generate a set of biomarkers. One or more biomarkers of the set may be combined to generate one or more additional biomarkers. A summary and one or more recommendations may be generated based, at least in part, upon the generated set of biomarkers and the additional biomarkers. The generated summary and the one or more recommendations may be provided for display on a client device. on a client device. pr p r

A system and method for evaluating the level of harassment of insects on a plurality of animals

Resumen de: AU2026202539A1

A SYSTEM AND METHOD FOR EVALUATING THE LEVEL OF HARASSMENT OF INSECTS ON A PLURALITY OF ANIMALS The presently disclosed subject matter aims to a system and method for evaluating the level of harassment of flying insects on a plurality of animals located at a given area, 5 the system comprising a processing circuitry configured to: obtain one or more ear movement patterns associated with at least one ear of at least one animal of the plurality of animals, each ear movement pattern is associated with respective ear movement characteristics; for at least part of the one or more ear movement patterns, determine whether their respective ear movement characteristics meet a predefined rule; and, 10 determine whether a number of ear movement patterns whose ear movement characteristics met the predefined rule meets an action requirement rule. A SYSTEM AND METHOD FOR EVALUATING THE LEVEL OF pr p r

AUTOMATED ASSESSMENT OF COGNITIVE AND SPEECH MOTOR IMPAIRMENT

Resumen de: US20260108202A1

The application relates to assessing cognitive impairment and/or speech motor impairment. The method comprises analysing a voice recording from a word-reading test by identifying a plurality of segments of the voice recording that correspond to single words or syllables and determining the number of correctly read words in the voice recording and/or the speech rate. Determining the correct number of words in the recording may comprise computing one or more Mel-frequency cepstral coefficients for the segments, clustering the resulting vectors of values into n clusters, wherein each cluster has n possible labels, predicting a sequence of words in the voice recording using the labels associated with the clustered vectors of values, performing a sequence alignment between the predicted sequence of words and the sequence of words used in the word reading test, selecting the labels that result in the best alignment and counting the number of matches in the alignment.

COMPOSITE SCAFFOLD FOR THE REPAIR, RECONSTRUCTION, AND REGENERATION OF SOFT TISSUES

Resumen de: US20260108345A1

The disclosed composite scaffold provides a highly porous and flexible structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement of the repair or reconstruction-first via scaffold mechanical properties, and subsequently, through newly regenerated functional tissue as the scaffold is resorbed.

Systems and methods for automating clinical workflow decisions and generating a priority read indicator

Resumen de: AU2026202531A1

Attorney Docket No. 04576.0100WOU1 / BSH.0124 Examples of the present disclosure describe systems and methods for automating clinical workflow decisions. In aspects, patient data may be collected from multiple data sources, such as patient records, imaging data, etc. The patient data may be processed using an artificial intelligence (AI) component. The output of the AI component may be used by healthcare professionals to inform healthcare decisions for patients. The output of the AI component and additional information relating to the healthcare decisions and healthcare paths may be provided as input to a decision analysis component. The decision analysis component may process the input and output an automated healthcare recommendation that may be used to further inform the healthcare decisions of the healthcare professionals. In some aspects, the output of the decision analysis component may be used to determine a priority or timeline for performing one or more actions relating to patient healthcare. pr p r

FACIAL RECONSTRUCTION IMPLANT KIT

Resumen de: US20260108318A1

0000 In an aspect, a method of manufacturing a surgical kit includes providing one or more medical devices based on a three-dimensional (3D) image of an anatomical structure. The method additionally includes providing packaging based on the 3D image, and providing the surgical kit utilizing the packaging and the one or more medical devices. In another aspect, a surgical kit has one or more contoured packaging surface having a contour that matches a contour of an anatomical structure. The contoured packaging surface has one or more features for receiving one or more medical devices provided based on the contour in the 3D image. The surgical kit additionally has a lid connected under pressure with the one or more contoured packaging surface. The lid has apertures for sterilization of components of the one or more medical devices situated between the lid and the contoured packaging surface.

ARRHYTHMIA DETECTION WITH FEATURE DELINEATION AND MACHINE LEARNING

Resumen de: US20260108198A1

Techniques are disclosed for using both feature delineation and machine learning to detect cardiac arrhythmia. A computing device receives cardiac electrogram data of a patient sensed by a medical device. The computing device obtains, via feature-based delineation of the cardiac electrogram data, a first classification of arrhythmia in the patient. The computing device applies a machine learning model to the received cardiac electrogram data to obtain a second classification of arrhythmia in the patient. As one example, the computing device uses the first and second classifications to determine whether an episode of arrhythmia has occurred in the patient. As another example, the computing device uses the second classification to verify the first classification of arrhythmia in the patient. The computing device outputs a report indicating that the episode of arrhythmia has occurred and one or more cardiac features that coincide with the episode of arrhythmia.

System for creating a composite map

Resumen de: AU2026202533A1

22549546_1 (GHMatters) P117197.AU.1 Provided herein are systems for modeling a patient’s cardiac electrical activity data, including at least one diagnostic catheter for insertion into the heart of the patient and a processing unit. The at least one diagnostic catheter includes at least one recording element to record patient data over multiple cardiac cycles. The patient data includes biopotential data and localization data of the at least one recording element. The processing unit includes a clustering routine that: receives the recorded patient data; segments the recorded patient data by cardiac cycle to produce segmented patient data; groups the segments based on one or more characteristics of the segments to produce segmented data groups; and combines the segmented patient data within each segmented data group to produce one or more composite recordings. The systems create one or more models of cardiac electrical activity of the patient based on the one or more composite recordings. pr p r

THREE-DIMENSIONAL PRINTED STRUCTURAL SILOXANES HAVING CONTROLLED DRUG RELEASE

Resumen de: US20260108468A1

0000 A product of additive manufacturing with a silicone-based ink having core-shell microspheres, where the product has a plurality of continuous filaments. The product includes a plurality of core-shell microspheres. Each core-shell microsphere includes a polyorganosiloxane shell and one or more cores inside the shell, at least one of the cores having a carrier and at least one component configured to be released post processing. An average diameter of the cores of the plurality of core-shell microspheres is in a range of greater than 2 μm to less than about 100 μm.

MICROCURRENT-STIMULATION-THERAPY APPARATUS AND METHOD

Resumen de: US20260108739A1

0000 A system and method for applying stimulation therapy to a patient, the system including a first stimulation strip that includes a first elongated portion configured to be placed on the upper eyelid of the first eye of the patient and a second elongated portion configured to be placed on the lower eyelid of the first eye of the patient, wherein the first stimulation strip includes: a first plurality of individually controlled electrodes configured to deliver a microcurrent stimulation therapy to the patient, a first plurality of individually controlled light emitters configured to deliver light stimulation therapy to the patient, and a first plurality of individually controlled heat sources configured to deliver heat therapy to the patient; and a controller operatively coupled to the first stimulation strip and configured to control delivery of the microcurrent stimulation therapy, the light stimulation therapy, and the heat therapy.

METHOD AND ANALYSIS SYSTEM FOR CREATING A DIGITAL 3D MODEL OF THE DENTITION OF A PATIENT

Resumen de: US20260108329A1

A method for creating a digital 3D model of a patient's dentition, according to the invention, provides that in a computing unit for a plurality of dentition variants, each comprising a combination of a digital 3D model of the upper jaw and a digital 3D model of the lower jaw of the patient, which differ from each other in the relative positioning of the upper and lower jaws, respectively: the digital 3D model of the upper jaw is combined with the digital 3D model of the patient's lower jaw in such a way that the upper and lower jaws rest on each other at a number of contact points without any spatial overlap of parts of the upper and lower jaws, andthe contact surface between the upper and lower jaw is determined, whereby an optimized denture variant is selected as a 3D model of the denture, taking into account the contact surface.

MATERIAL AND METHOD FOR PRODUCING CELL RECEIVING SCAFFOLD

Resumen de: US20260109952A1

A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.

Spinal Implants With Custom Density And 3-D Printing Of Spinal Implants

Resumen de: US20260108359A1

In some embodiments, a spinal implant (10, 110, 210, 310, 400) is provided and includes a body portion defining a longitudinal axis. The body portion includes a distal end portion, a proximal end portion, opposed side surfaces that extend between the distal and proximal end portions, and top and bottom surfaces configured and adapted to engage vertebral bodies. The top and bottom surfaces have a surface roughness between 3-4 μm. A cavity extends through the top and bottom surfaces defining a surface area that is at least 25% of a surface area of the top surface or the bottom surface. First orifices (24, 124, 224, 324, 426a) are defined through the top surface and second orifices (34, 134, 234, 334, 426b) are defined through the bottom surface. The second orifices are connected to the first orifices by a plurality of channels.

MOTORIZED STRUT MOTOR FEEDBACK

Resumen de: US20260108275A1

A spatial frame apparatus for positioning on a patient to treat an injury. The apparatus includes a frame having one or more motorized struts. One or more motorized struts include one or more motors configured to cause movement of one or more motorized struts in one or more directions in accordance with one or more treatment plans. The apparatus includes one or more processing 2024/102351 components communicatively coupled to one or more motorized struts and/or one or more motors. One or more processing components determine one or more loading parameters on the one or more motorized struts. The loading parameters define loading on the one or more motorized struts resulting from the frame being positioned and/or adjusted on the patient. The processing components execute at least one adjustment of one or more motorized struts based on the determined loading parameters.

METHOD FOR SMART ENERGY DEVICE INFRASTRUCTURE

Resumen de: US20260108134A1

A method for characterizing a state of an end effector of an ultrasonic device is disclosed. The ultrasonic device including an electromechanical ultrasonic system defined by a predetermined resonant frequency. The electromechanical ultrasonic system further including an ultrasonic transducer coupled to an ultrasonic blade. The method including applying, by an energy source, a power level to the ultrasonic transducer; measuring, by a control circuit coupled to a memory, an impedance value of the ultrasonic transducer; comparing, by the control circuit, the impedance value to a reference impedance value stored in the memory; classifying, by the control circuit, the impedance value based on the comparison; characterizing, by the control circuit, the state of the electromechanical ultrasonic system based on the classification of the impedance value; and adjusting, by the control circuit, the power level applied to the ultrasonic transducer based on the characterization of the state of the end effector.

Smart Pack System for Medicines

Resumen de: US20260108427A1

Disclosed is a blister pack smart dispensing package that has an overlay with conductors located over blister pack pockets that are broken when a user retrieves a solid medication, such as a pill, from the blister pack. The date and time that the user retrieved the solid medication from the smart pack is recorded by an electronics and communications package on the smart pack. A local communications device then receives this adherence data and transmits this data to a server, which generates a data structure containing adherence data. A blister pack overlay can be used which changes colors to indicate that the medication is about to expire, or has expired.

3D PRINTING INK COMPOSITION AND 3D PRINTING MOLDED ARTICLE FORMED BY CURING SAME

Resumen de: WO2026084480A1

The present disclosure relates to: a 3D printing ink composition comprising alginate, a biocompatible hydrogel, acrylamide-based monomers, a photocrosslinkable polymer, a light absorber, and a solvent; and a 3D printing molded article formed by curing the composition.

3D PRINTED OR OTHER ANATOMICAL AND CIRCULAR GINGIVAL HEALING CUFFS FOR USE WITH ABUTMENTS

Nº publicación: US20260108327A1 23/04/2026

Solicitante:

ESTHETIC IMPLANT SOLUTIONS LLC [US]

Resumen de: US20260108327A1

An assembly comprising an abutment and gingival healing cuff. The gingival healing cuff fits and mates over the abutment, wherein the cuff includes internal surfaces (e.g., at least one flat face, and at least one curved face) corresponding to the external surfaces of the abutment, so as to mate with one another. The gingival healing cuff can further include a rectangular box or other timing alignment structure positioned apical to a buccal alignment body, which serves as a buccal alignment marker once the buccal alignment body is removed, and which can aid in helping the practitioner know where the implant platform and abutment platform are located (even when hidden). Flowable composite, e.g., of a different color, can be placed into the rectangular box or other timing alignment structure to aid in identification of the buccal surface of the cuff and proper rotational alignment (“timing”) of the abutment with the implant.