Alerta

BIOCOMPATIBLE GRANULE STRUCTURES

Resumen de: WO2025117313A1

The present disclosure provides biocompatible granule structures and associated assemblies and methods. These biocompatible granule structures are introduced into a void or space in a bone structure or between bone structures disposed on a flexible elongate structure to partially fill the volume and promote bony ingrowth and healing in a variety of surgical applications, such as kyphoplasty and vertebroplasty procedures and the like. The biocompatible granule structures are made of a bony substance or a biocompatible metallic, ceramic, or polymeric material and provide superior migration, interlocking behavior, and bony purchase and ingrowth properties.

HELMET FOR NONINVASIVE BRAIN STIMULATION

Resumen de: WO2025111627A1

The invention relates to a helmet (1) for a noninvasive brain stimulation, comprising a stimulation unit (3) oriented towards a head-receiving area (2). In order to allow an individually determinable stimulation region to be precisely irradiated while nevertheless allowing the test person to have a certain degree of mobility, a suction opening (4) is proposed which is open towards the head-receiving area (1) and which is fluidically connected to a negative pressure connection (6) positioned outside of the head-receiving area (2).

SCAFFOLDS BASED ON CONTINUOUS FOLDED SHEETS

Resumen de: WO2025117862A1

Provided herein are various embodiments related to the design, creation, and use of a folded sheet scaffold for medical devices. The scaffold comprises a shellular porous pseudorandom orientable architecture composed of a continuous folded sheet of topological genus-n. Methods for designing the scaffold involve driving noise from an infinite 3D noise field to define a field with real space, tuning field values based on user input, and subtracting to create thin wall geometry. The methods can be computer-implemented or executed by a processor following instructions stored on a non-transitory computer-readable medium. A computer system for designing the scaffold includes modules for noise-driving, tuning, and subtracting. The disclosure also includes a folded sheet scaffold formed by these methods and a medical device comprising the folded sheet scaffold.

POLYETHER-CONTAINING POLYMERIZABLE COMPOUNDS AND USE IN CURABLE RESIN COMPOSITIONS

Resumen de: WO2025117528A1

This disclosure provides polymerizable resin compositions comprising a hydrophobic polyether-containing polymerizable polyurethane compound to impart improved stain resistance to polymeric materials formed from the polymerizable resin compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of dental devices, such as orthodontic appliances.

ORAL DEVICE AND METHODS OF PRODUCING AND USING SAME

Resumen de: WO2025117762A1

An oral device configured for delivery of a liquid to the mouth of the subject is disclosed, along with kits and systems containing same, and methods of producing and using same. The oral device includes a base component comprising a reservoir that is configured for receiving a volume of liquid and contains a wicking agent disposed therein that dispenses liquid via capillary action. The base component also includes at least one opening formed therein for delivery of the liquid to the subject.

LASER MARKABLE RESIN COMPOSITIONS FOR ORTHODONTIC APPLIANCES

Resumen de: WO2025117572A1

This disclosure provides laser markable polymerizable resin compositions comprising infrared absorbing marking additives to achieve improved laser markability of 3-D printed objects obtained from these polymerizable resin composition, and methods for marking the cured resin compositions using an infrared laser.

APPARATUS FOR PERIPHERAL OR SPINAL STIMULATION

Resumen de: EP4819391A2

0001 The present invention discloses an implantable device for use with an external system configured to transmit a transmission signal comprising a power signal, the implantable device comprising at least one implantable antenna configured to receive the transmission signal from the external system, an implantable receiver configured to receive the transmission signal from the at least one implantable antenna, at least one implantable functional element configured to interface with tissue of a patient, an implantable controller configured to control the at least one implantable functional element, an implantable energy storage assembly configured to provide power to at least one of the at least one implantable functional element, the implantable controller, and the implantable receiver; and an implantable housing surrounding at least the implantable controller and the implantable receiver, wherein the implantable controller is configured to transmit or control the transmission of a stimulation signal to the at least one implantable functional element independently of the received power signal using stored energy, to deliver the stimulation signal to the tissue of the patient.

SYSTEMS AND METHODS FOR MIRRORING AN INTERFACE OF A MEDICAL DEVICE

Resumen de: EP4819155A1

0001 An example system includes an external device and a monitor-defibrillator. The monitor-defibrillator may include a detection circuit configured to detect an electrical signal indicative of an electrocardiogram (ECG) of a subject, a transceiver, a display and a processor configured to determine that the display is unable to visually present the ECG. In response to determining that the display is unable to visually present the ECG, the transceiver can transmit, to the external device, an instruction to display the ECG such that the ECG is mirrored via an external display of the external device.

Network-connected containers having medication stored therein

Resumen de: US12751901B1

Introduced here are containers designed to promote compliance with regimens for administering the medications stored therein. These containers have various features that allow them to be more easily managed by the individuals to whom the medications were prescribed. Some features improve the ease with which containers communicate with individuals. These features may enable information to be more easily input by individuals and/or output for individuals in a comprehensible manner. Other features improve the mechanical or electrical durability of containers. Such features may enable the containers to be used by individuals over the course of several days, weeks, or months without worrying about structural damage or loss of power.

一种钛合金外冠及其加工方法和应用

Resumen de: CN122850812A

本发明提供一种钛合金外冠及其加工方法和应用，属于口腔修复体精密制造、增材制造与数控复合加工技术领域。该钛合金外冠的加工方法基于“3D打印+五轴数控机加工”复合加工方法，3D打印负责外冠主体结构及复杂内腔的快速近净成型，充分发挥增材制造在成型复杂几何特征上的优势，大幅减少材料损耗与成型工时；五轴数控机加工则专门负责外冠关键功能面的精密加工，充分发挥减材制造在尺寸精度和表面质量上的优势，两种工艺各司其职、优势互补，从根本上解决了单一工艺无法同时兼顾复杂结构成型与精密功能面加工的行业难题；且打印、机加工、装配检验过程中坯体与工装始终保持固连状态，通过工装流转，实现增材制造与减材加工全流程基准统一。

一种缓解视疲劳的药食同源功能性多重乳液凝胶及其制备方法和应用

Resumen de: CN122848465A

本发明公开了一种缓解视疲劳的药食同源功能性多重乳液凝胶及其制备方法和应用，属于食品加工技术领域。本发明采用亲水性低共熔溶剂提取并负载枸杞多糖和花青素，以亲油性低共熔溶剂提取并负载叶黄素酯和水飞蓟素；其中亲油性低共熔溶剂由十二烷酸与薄荷醇复配而成，利用十二烷酸的质子化/去质子化转变实现胃肠道pH响应释放；凝胶体系采用燕麦β‑葡聚糖与低DE值麦芽糊精复配，利用二者弱热力学不相容性使麦芽糊精物理截留于β‑葡聚糖凝胶网络孔隙中，赋予凝胶温度响应与口腔酶响应特性。该凝胶通过温度‑酶‑pH三响应实现加工成型、安全吞咽与肠道精准释放，适用于吞咽困难老年人群的视疲劳缓解与视力保护。

个性化头部电极的电极帽头架的生成方法、装置、设备、产品及存储介质

Resumen de: CN122863642A

本申请公开了头部电极的电极帽头架的生成方法、装置、设备、产品及存储介质，所述方法包括从脑影像中提取头皮表面的坐标，基于预设解剖标志点构建变换矩阵并将多个电极的坐标变换到头部空间并投影到头皮表面，确定多个电极在所述头皮表面的电极位置；构建电极座模型，基于电极邻接字典提取拟定电极集合中的电极间的有效边和进一步确定连接边，构建连接边的结构路径以在其上的多个采样点构建连接带截面，连接截面以构建连接带模型，合并电极位置、电极座模型和连接带模型得到头架模型；控制制造设备利用头架模型生成电极帽头架。所述方法根据个体脑影像自动化生成头架，实现其中电极放置的个性化，消除人工测量带来的定位偏差，同时具有良好佩戴效果。

一种机械臂辅助式多流道原位生物打印喷头

Resumen de: CN122851968A

本发明公开了一种机械臂辅助式多流道原位生物打印喷头，包括法兰盘、主体支撑框架、控制单元、挤出单元、切换阀体及蓝光模组；法兰盘下方固接主体支撑框架，其外周壁均布支撑翼板并安装阀盖和伺服电机，伺服电机驱动旋转阀芯转动，阀芯内设L型导流通道，转动阀芯使L型通道进口与任一进料流道对接，出口与中心出料流道连通；支撑翼板下方固定挤出单元，各单元集成驱动、温控模块，并通过柔性软管与进料流道连通；中心出料流道下端连接点胶针头；切换阀体底部固设蓝光模组支架，其上均布有多个朝向针头的灯珠模块。本发明结构紧凑，集成多材料按需切换、精准挤出、温控及原位光固化功能，适用于复杂组织工程支架的原位生物打印。

一种多孔结构的生成方法及多孔结构模型

Resumen de: CN122863826A

本发明提供了一种多孔结构的生成方法及多孔结构模型，多孔结构的生成方法包括：生成基体模型，所述基体模型为多孔结构，所述基体模型具有用于与宿主骨接触的骨接触面；在所述基体模型的所述骨接触面上，通过异形结构与所述多孔结构的融合，形成界面粗糙度可控层；输出所述异形结构与所述多孔结构融合后的三维模型；其中，所述异形结构选自规则/不规则点阵结构或十二面体结构中的一种或多种。本发明的目的在于弥补假体多孔结构骨接触面粗糙度的方案普遍存在的缺陷，通过异形结构与基体多孔结构的融合，在不破坏基体多孔结构完整性的前提下，实现骨接触面粗糙度的精准可控，同时从根源上规避现有粗糙化技术带来的临床风险。

一种高精度高稳定性的3D打印物理改性葛根粉凝胶食品及其应用

Resumen de: CN122848432A

本发明公开了一种高精度高稳定性的3D打印物理改性葛根粉凝胶食品及其应用，属于葛根食品生产开发和淀粉基食品3D打印技术领域。本发明通过对葛根粉的递送方式以及葛根粉的改性方式做出了改进，提供了一种物理改性葛根粉凝胶用于食品3D打印，进而创制个性化葛根粉凝胶食品的方法，为葛根食品生产制造提供了全新的思路，并且通过清洁无污染、低门槛、低成本的方式，解决了其在食品3D打印过程中遇到的支撑不足、打印精度低、渗水率高、口感风味不佳的问题。

URNE FUNÉRAIRE LUMINEUSE PERSONNALISÉE EN LITHOPHANIE

Resumen de: FR3173461A1

L’invention porte sur une urne funéraire lumineuse personnalisée, conçue pour les animaux de compagnie. Grâce à l’impression 3D et à la lithophanie, cette urne permet de conserver une présence symbolique de l’animal tout en offrant un hommage apaisant. La lumière intégrée révèle le portrait gravé et crée une atmosphère réconfortante pour les propriétaires en deuil.

异种口腔修复组合物以及其植入物

Resumen de: WO2025147712A1

The present disclosure relates generally to oral tissue repair compositions and implants thereof; and, more particularly, to customized acellular extracellular matrix repair compositions and implants for patient-specific treatment of various oral tissue defects, such as periodontal recession.

一种3D打印再造鼻翼软骨GelMA复合生物墨水

Resumen de: CN122849549A

本发明涉及生物医用材料及3D生物打印技术领域，具体涉及一种3D打印再造鼻翼软骨GelMA复合生物墨水。该生物墨水包括聚乙烯醇PVA、甲基丙烯酸化明胶GelMA和纳米二氧化硅SiO2，其中PVA形成支撑骨架，GelMA经光交联形成柔性网络，纳米SiO2分散于复合体系中以增强支架力学性能。通过流变学测试匹配18G喷嘴、打印速度和层厚，并依据受术者CT或MRI数据建立个体化鼻翼软骨三维模型，逐层打印形成孔隙率达80%以上的多尺度多孔仿生支架。所得支架兼具连续挤出性、形状保持性、软骨样弹性及细胞相容性，可提高与目标软骨组织的力学匹配程度，并为软骨细胞迁移、黏附、增殖及新生软骨形成提供适宜空间。

SYSTEMS AND METHODS FOR PRINTING A CORE FIBER

Resumen de: WO2020056517A1

A print head, system and method for producing hollow fiber structures, for example three-dimensional biological structures comprising living cells, includes a dispensing channel, a core channel converging with the proximal end of the dispensing channel, a first shell channel converging with the core channel and the dispensing channel at a focusing intersection or chamber, and a sheath flow channel converging with the dispensing channel at a sheath flow intersection or chamber located between the focusing intersection or chamber and the distal end of the dispensing channel. The diameter of the dispensing channel increases from a first diameter to a second diameter at the sheath flow intersection or chamber, and the core channel has a third diameter less than the first and second diameters. The sheath flow channel includes sheath flow sub-channels and the focusing chamber has a conical frustum shape.

DENTAL ZIRCONIA 3D-PRINTED ARTICLE HAVING COLOR AND TRANSLUCENCY GRADIENTS AND MANUFACTURING METHOD THEREFOR

Resumen de: WO2026205957A1

The present invention relates to a dental zirconia 3D-printed article having color and translucency gradients and a manufacturing method therefor and, specifically, to a dental zirconia 3D-printed article and a manufacturing method therefor, the dental zirconia 3D-printed article comprising at least two types of yttria-stabilized zirconia (YSZ) doped with different contents of yttria (Y2O3), wherein the at least two types of yttria-stabilized zirconia are selectively doped with a colorant to have gradients in color and translucency.

DENTAL PRODUCT FORMED BY 3D PRINTING AND METHOD FOR MANUFACTURING DENTAL PRODUCT

Resumen de: WO2026200932A1

The present application relates to a dental product formed by 3D printing, comprising: a first body, comprising a portion made of a first material; and a second body, connected to the first body and comprising a portion made of a second material, wherein the first material and the second material have different colors or transparencies. The dental product provided in the present application meets at least one application requirement.

METHODS AND SYSTEMS FOR ASSISTING A DENTAL RESTORATION PROGRAMME

Resumen de: WO2026201517A1

Provided herein is a method (100) for preparing a prosthetic crown for a subject or assisting a dental restoration programme comprising one or more dental sessions for fitting a prosthetic crown into a subject, the method comprising: receiving a planning dataset, 3D- PLAN (120), wherein the 3D-PLAN comprises three-dimensional dental measurement data of the subject as presented prior to an intervention, wherein: the intervention includes implanting an implant in a defined pose for later addition of the prosthetic crown; and the 3D-PLAN: is used for a planning and execution of the intervention; and is used for a preparation of a preliminary design of the prosthetic crown; receiving a local 3D post- intervention measurement dataset, L3D-POI (140), wherein the L3D-POI has been obtained by a three-dimensional contactless measurement of the intervention site, wherein the intervention site comprises the implant, wherein the implant has been fitted to a jawbone of the subject to support the prosthetic crown, and the L3D-POI includes a three- dimensional measurement data of at least a coronal portion of the in situ implant; determining (200), from the 3D-PLAN (120) and L3D-POI (140), a 3D patient specific dental component, 3D PSDC, dataset (220), from which the 3D PSDC is able to be prepared; and outputting (230) the 3D PSDC dataset (220) for transmission (290) to a device (300) for additive manufacturing, thereby allowing an additive manufacture of a 3D printed PSDC, wherein the 3D p

THREE DIMENSIONAL PRINTABLE BIODEGRADABLE METAL INFUSED BONE REGENERATIVE MATERIAL UTILIZING ADDITIVE MANUFACTURING FOR BONE TISSUE ENGINEERING

Resumen de: WO2026207093A1

A bioactive composite filament for fused-deposition modeling comprises 10 vol% to about 60 vol% biodegradable metal powder (about 10 µm to about 100 µm particle size) and about 40 vol% to about 90 vol% biocompatible thermoplastic polymer. The filament exhibits controlled rheology (viscosity ≤ 5.5×10⁵ Pa·s at 120 °C), enhanced mechanical properties (up to 3-fold increase in tensile modulus), and printability with high fidelity (print score ≥ 0.85). Three-dimensional scaffolds manufactured from the filament demonstrate pH-neutral degradation, composition-tunable metal ion release, and sustained bioactivity with greater than 95% cell viability over 21 days. The manufacturing process involves cryogenic milling, inert-atmosphere blending, screw extrusion, and layer-by-layer deposition to produce porous scaffolds or non-porous implants for bone tissue engineering and orthopedic applications.

AUTOMATED TOOTH IMPLANT PLANNING

Resumen de: WO2026202082A1

A computer-implemented method for automated planning of a tooth implant in a dento-maxillofacial complex is described, wherein the method includes receiving or determining 3D virtual patient data representing a dento-maxillofacial complex comprising anatomical structures and at least one area of interest for placing the tooth implant, the 3D virtual patient data including 3D representations of anatomical structures within a vicinity of the at least one area of interest; determining a tooth implant model and/or one or more implant parameters defining a tooth implant model to be positioned at the at least one area of interest, using an implant planning engine, the implant planning engine being configured to receive the 3D representations of anatomical structures within a vicinity of the area of interest and to determine the tooth implant model and/or one or more implant parameters defining a tooth implant model based on clinical constraints, the clinical constraints including distance requirements of the tooth implant with regard to at least part of the 3D representations of the anatomical structures; and, rendering the implant model on a display or transforming the implant model into a data format for controlling a manufacturing apparatus, such as a 3D printer, to manufacture the tooth implant.

MANUFACTURING METHOD FOR MASS PRODUCTION AND RECYCLING OF VARIABLE-STIFFNESS INTRAVENOUS NEEDLES OF VARIOUS SIZES THAT BECOME SOFTENED BY BODY TEMPERATURE

Nº publicación: WO2026205644A1 01/10/2026

Solicitante:

KOREA ADVANCED INST OF SCIENCE AND TECHNOLOGY [KR]
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Resumen de: WO2026205644A1

The present disclosure relates to a manufacturing method for the mass production and recycling of variable-stiffness intravenous needles of various sizes that become softened by body temperature, the method comprising the steps of: preparing a mold, which is manufactured by 3D printing and has a plurality of elongated channels aligned therein, and a plurality of elongated rods, which can be coaxially arranged in the respective channels; applying a material having variable stiffness according to ambient temperature to the mold so as to encompass each of the rods in the channels; curing the material, and removing the mold and the rods so as to leave a plurality of hollow body members; and forming coating members having biocompatibility so as to cover the respective outer surfaces of the body members, thereby leaving a plurality of variable-stiffness intravenous needles.