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Medical device based on bioceramics, its use as a synthetic bone graft and process for the preparation thereof

Resumen de: GB2639318A

The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.

FUNCTIONALLY-DIVIDABLE ORODISPERSIVE DOSAGE FORM

Resumen de: WO2024108084A1

A dividable tablet with a functional seam for functionally dividing the dividable tablet into substantially equivalent sub-dosage units along the functional seam. The functional seam is configured to subdivide the sub-dosage units into the same mass within a tolerance of about 3% or less, and typically of 1.0% or less. The functional seam is configured reduce the amount of lost material that separates from the divided sub-dosage units after divi sion of the dividable tablet along the functional seam, to less than 3%, and typically less than 1.0%, and more typically less than 0.1% of the mass of the undivided dividable tablet.

ASSEMBLY FOR CARRYING A DENTAL PROSTHESIS AND A METHOD OF MANUFACTURING THE SAME

Resumen de: WO2024104515A1

The object of the invention is an assembly for carrying a dental prosthesis and a method of manufacturing the same, wherein the assembly for carrying a dental prosthesis comprises a dental implant (1 ), a fixation screw (2), and a pillar (3) for fixing the dental prosthesis, where the pillar (3) comprises a first end (4) of the pillar, a second end (5) of the pillar opposite the first end (4) of the pillar, and a cavity (6) of the pillar, wherein the cavity (6) of the pillar opens at both the first and second ends (4,5) of the pillar and the first end (4) of the pillar is adjacent to the dental implant (1 ), wherein at least a part of the fixation screw (2) is located in the cavity (6) of the pillar and the fixation screw (2) is connected to the dental implant (1 ), wherein the cavity (6) of the pillar comprises a first side (7) of the cavity comprising a first section (8) of the cavity and a second side (9) of the cavity comprising a second section (10) of the cavity, wherein the first side (7) of the cavity is located closer to the first end (4) of the pillar than the second side (9) of the cavity and the cross-section of the first section (8) of the cavity is larger than the cross-section of the second section (10) of the cavity, wherein the fixation screw (2) comprises a head (11 ) of the fixation screw that is located in the first side (7) of the cavity.

可术中调整的椎弓根钉导板

Resumen de: CN223365636U

本实用新型属于医疗器械领域，涉及一种可术中调整的椎弓根钉导板，包括横跨棘突的导板本体，导板本体端部固设有用于与脊椎骨面贴合的定位板，导板本体上设置有与规划置钉方向平行的导向柱，定位板上与规划置钉点相对应的位置开设有导向槽。本实用新型通过半开放式的定位方式，使定位具备了一定的自由度和灵活度，术中可以进行二次调整和定位，提高了置钉的精准性，且便于术中导板的取出，同时节省了耗材成本，适用于椎弓根钉内固定术中椎弓根钉的定位。

用于下颌运动记录设备的个性化夹具

Resumen de: CN223365542U

本实用新型公开了一种用于下颌运动记录设备的个性化夹具，涉及牙科器械技术领域，包括：口内粘接装置，包括第一板体和第二板体，所述第一板体设置有两块，每块所述第一板体均呈弧形，且与相邻下槽牙牙面的弧度相适配，两块所述第一板体分别用于粘接在两侧的下槽牙唇侧，所述第二板体位于下颌牙的唇侧，且两块所述第一板体分别固定连接在所述第二板体的两侧，所述第二板体与下颌牙唇侧之间的间距大于等于上颌牙的厚度；固定器，用于安装下颌运动记录仪的下颌传感器。本申请的技术方案通过将第二板体与下颌牙唇侧之间的间距设置为大于等于上颌牙的厚度，可确保深覆颌受试者在使用该装置时上颌牙与下颌牙侧向运动期间不会产生干扰。

一种用于分阶段骨再生的3D生物打印径向多孔支架及其制备方法

Resumen de: CN120678997A

本发明公开了一种用于分阶段骨再生的3D生物打印径向多孔支架及其制备方法，所述3D生物打印径向多孔支架可以提供仿生细胞微环境，以支持宿主修复细胞向缺损部位的渗透，并在植入后促进骨整合，此外，所述3D生物打印径向多孔支架中含有的双重生长因子的序贯释放和后期PO43‑和Ca2+的持续释放可以完成分阶段骨再生的三个关键步骤，能够实现高效骨再生，代表了一种有前景的仿生阶段性再生策略。

深层组织的体内打印

Resumen de: WO2024173885A1

Techniques for deep tissue in vivo printing are described. Some implementations of the disclosure relate to a method that includes: obtaining a biopolymer mixture including prepolymer material and a crosslinking agent encapsulated in carrier particles; delivering the biopolymer mixture to a subcutaneous or deep tissue target location of a subject; and transmitting with a bioprinting device, via transcutaneous application, radiation to the subcutaneous or deep tissue target location, the radiation configured to cause the carrier particles to release at least some of the crosslinking agent, the released crosslinking agent configured to cause the prepolymer material to form into a gel or polymeric matrix.

一种用于葡萄糖响应性DLP 3D打印胶原蛋白生物墨水、制备方法及应用

Resumen de: CN120678985A

本发明属于生物医用材料技术领域，具体涉及一种用于葡萄糖响应性DLP 3D打印胶原蛋白生物墨水、制备方法及应用。本发明提供了一种葡萄糖响应性DLP 3D打印胶原蛋白生物墨水；所述生物墨水在pH 7的生理条件下可制备具有良好的机械性能、保真度和抗降解能力的水凝胶；且该凝胶可在高血糖环境下进行响应性释放；释放的姜黄素可以清除细胞内ROS，调控巨噬细胞炎症因子表达，发挥抗氧化抗炎功效，并且凝胶材料还能够促进细胞的增殖、黏附、迁移，具有良好的生物相容性和生物活性；在为糖尿病创面治疗提供了兼具智能释药、力学适配与主动促愈功能的个性化解决方案。

一种种植基台的牙冠批量打印装置及方法

Resumen de: CN120680724A

本发明提供了一种种植基台的牙冠批量打印装置及方法包括：利用牙龈形态数据库对患者牙龈采样数据进行深度优化，确定患者的基台排布特征并确定所述患者的基台打印数据，根据所述患者的已提需求和所述基台排布特征创建所述患者的若干种牙冠形态，并构建每一所述牙冠形态对应的牙冠打印数据，根据所述患者的面部数据分别模拟每一所述牙冠打印数据对应的打印效果，根据指令选取目标牙冠打印数据，根据所述基台打印数据和所述目标牙冠打印数据分别打印所述患者的基台和牙冠，根据患者的需求和实际取模结果自动调整打印设备的激光功率和打印预备工作，可以实现牙冠和基台的批量打印或个性化打印，提高了打印的效率，确保了打印成品的质量。

一种基于FDM多材料3D打印的微电流面膜及其制备方法

Resumen de: CN120678663A

本发明公开一种基于FDM多材料3D打印的微电流面膜及其制备方法，所述微电流面膜包括薄膜电池层、支撑层、活性成分层和吸附层，通过采用多层叠覆式结构设计，各层之间相互配合，由内而外依次设置，各层面积按照面部的弧度和轮廓逐渐递减，通过正金字塔型逐级递减的面积设计增强微电流面膜的贴合度，根据面部轮廓更好地贴合皮肤，减少对面部的拉扯和不适感。所述微电流面膜的制备方法，基于用户面部扫描数据，并通过多维特征融合分析，将获取的数据进行整合分析，使得建立的三维模型更为自然和贴切用户的实际面部，实现精确定制微电流面膜，提高微电流面膜的贴合度和舒适性；同时采用了FDM多材料3D打印技术，支持多材料的精确组合和功能集成，增强微电流面膜的功效性和安全性。

使用三维模型制造物体的方法和系统

Resumen de: CN120680723A

本申请涉及一种三维模型制造物体的方法和系统。上述方法包括：获取多个待打印的三维模型，三维模型包括模型关联信息，根据模型关联信息将各三维模型存储至一个或多个存储单元中，从指定存储单元中自动抓取至少一个目标三维模型，对目标三维模型进行排版处理，得到排版结果，基于排版结果，对目标三维模型进行三维打印。采用本方法能够能够在三维模型文件设计完成后，分类存储，自动抓取数据，自动完成前处理，并自动下发至三维打印设备进行三维打印，全程无需人工任何操作，提高三维模型的打印效率。

全口义齿及全流程数字化的全口义齿制作方法

Resumen de: CN120678548A

本发明公开全口义齿及全流程数字化的全口义齿制作方法。本发明以光学印模替代传统印模，电子运动面弓+下颌运动轨迹描记替代机械面弓+哥特式弓描记，结合语音法显示的下颌轨迹特征，替代传统的颌位记录，技术敏感性更低，颌位关系记录更精准，在口扫后过软件预排牙和电子面弓直接生成咬合方案，省去蜡型试戴、传统的颌位记录等中间步骤，且本申请采用数字化制造减少手工操作，三维打印/切削技术直接输出义齿，省去装盒、煮牙、打磨等繁琐工序，制作周期大大缩短，往后二次复制或再制作时间及适应时间大大等缩短，并为全口种植咬合重建颌位提供数字化解决方案，更利于数智数据的开发、整合等。

医用组织包裹物

Resumen de: AU2023370241A1

The invention relates to the field of medical tissue wraps for internal anatomical structures as well as a use and a method of treating a nerve lesion using such medical tissue wraps. In particular, the invention relates to medical tissue wraps for neural tissue supporting the repair of peripheral nerve lesions by facilitating secure application of the medical tissue wrap. Accordingly, a medical tissue wrap (10) for an internal anatomical structure of a mammal is suggested, wherein the medical tissue wrap (10) is formed by a coiled wall (12) having a circumferential inner end portion (20) and a circumferential outer end portion (22) extending around and overlapping the circumferential inner end portion (20). The wall (12) thereby defines a longitudinal through-hole (16) for accommodating a portion of the anatomical structure. According to one aspect of the invention, the circumferential outer end portion (22) is radially spaced-apart from the circumferential inner end portion (20) by a discontinuous spacing in the circumferential direction. According to a further aspect, the tissue wrap comprises a structural outer surface modification at opposing longitudinal end portions of its wall.

用于3D打印的金属粉末

Resumen de: US2024123495A1

A method of using a metal powder in an additive manufacturing process. The method includes providing the metal powder, and using the metal powder in the additive manufacturing process. The metal powder is a metal which is selected from tantalum and impurities, titanium and impurities, niobium and impurities, an alloy of tantalum, niobium and impurities, an alloy of titanium, niobium and impurities, and an alloy of tantalum, titanium, niobium and impurities. Particles of the metal powder have a dendritic microstructure. Particles of the metal powder have an average aspect ratio ΨA of from 0.7 to 1, where ΨA=XFeret min/XFeret max.

一种仿生甲虫骨架植入物的制备方法

Resumen de: CN120680013A

本发明公开了一种仿生甲虫骨架植入物的制备方法，属于股骨植入领域。本发明创新性地将甲虫鞘翅和角质层的仿生结构特征相结合，通过仿生结构设计的方法有效提升了多孔镍钛合金结构植入体的力学强度和结构稳定性，成功解决了传统股骨金属植入物长期存在的应力屏蔽效应问题，采用选择性激光熔化（SLM）技术制备出的多孔镍钛合金仿生骨架结构，其不仅具有良好的力学适配性，避免了植入后与自然骨组织的排斥脱落反应，还能在室温环境下实现完全的形状记忆恢复功能，在医用骨科植入领域具备良好的应用前景。

一种氧化锌-氧化铝陶瓷骨修复支架的制备方法

Resumen de: CN120682021A

本发明涉及生物医学材料的技术领域，公开了一种氧化锌‑氧化铝陶瓷骨修复支架的制备方法；首先按照比例称取氧化铝造粒粉和酚醛树脂粉体，混合氧化铝造粒粉和酚醛树脂粉体，得到获得3D打印复合粉体；其次，将3D打印复合粉体通过选择性激光烧结设备，制备得到氧化铝陶瓷坯体；将氧化铝陶瓷坯体进行干燥，得到干燥后的陶瓷坯体，并将干燥后的陶瓷坯体进行脱脂和烧结处理，冷却得到氧化铝预成型体；最后，使用纳米氧化锌溶胶对所述氧化铝预成型体进行真空压力浸渗，并引入动麦优化算法对真空压力浸渗参数进行优化，得到氧化锌‑氧化铝陶瓷骨修复支架；本发明通过制备工艺和智能优化工艺参数得到氧化锌‑氧化铝陶瓷骨修复支架，方法客观准确。

光固化生物墨水、数字光处理3D打印产品及其制备方法和在制备颅骨修复材料中的应用

Resumen de: CN120661738A

本发明提供了光固化生物墨水、数字光处理3D打印产品及其制备方法和在制备颅骨修复材料中的应用，属于生物医药技术领域。本发明提供的材料能够在不同环境条件下持续地释放H₂O₂。尤其是在模拟体内环境中，GHDP水凝胶在较长时间内保持稳定的H₂O₂释放，从而不断激活血管生成相关的信号通路，在颅骨缺损修复过程中，能够通过调控H₂O₂水平，促进新生血管形成和成骨分化，为利用氧化还原信号调控来促进组织再生提供了新的策略与思路。

バイオプリントされた軟組織補強足場

Resumen de: CN119968177A

The present disclosure encompasses systems, compositions, and methods for use in vivo, including for enhancing soft tissue in an individual. The systems, compositions, and methods may utilize a three-dimensionally printed scaffold comprising at least a polymeric scaffold and an extracellular matrix component, including an extracellular matrix component contained on the scaffold. The polymer scaffold may include specific unit cell structures having a specific design and a pattern of alternating configurations of unit cell structures.

一种基于3D打印的可降解鼻大翼软骨支架及其制备方法

Resumen de: CN120661739A

本发明公开了一种基于3D打印的可降解鼻大翼软骨支架及其制备方法，支架由PLGA以及纳米羟基磷灰石复合基体、载药微球及梯度多孔仿生结构组成，表面覆盖壳聚糖涂层以增强细胞黏附性。通过调控PLGA分子量和羟基磷灰石含量实现降解速率与软骨再生速率匹配。支架内部嵌入载有地塞米松与TGF‑β的微球。制备方法结合熔融沉积3D多喷头协同打印技术与患者CT/MRI数据建模。相较于传统不可降解材料及现有可降解支架，本发明兼具力学适应性、降解可控性、药物功能集成化及临床适配性优势，适用于先天性鼻畸形、外伤性缺损修复及联合自体软骨移植治疗，有效解决了现有材料生物相容性差、降解速率失配及通用性不足等问题。

一种梯度致密度金属植入物增材制造方法

Resumen de: CN120662830A

本发明提供了一种梯度致密度金属植入物增材制造方法，涉及激光选区熔化增材制造技术领域，该方法通过多模态传感器融合与自适应控制算法，实现金属植入物从外层到内层的连续梯度致密度分布，精确模拟骨骼的生物力学特性，从而省去设计多孔结构的步骤；可精确模拟人体骨骼的皮质骨(高致密)与松质骨(多孔)结构，提升植入物的生物力学适配性。

一种光固化3D打印含碳导电多孔材料及其制备方法及应用

Resumen de: CN120665428A

本发明涉及一种光固化3D打印含碳导电多孔材料及其制备方法及应用。该方法基于巯基‑烯点击化学与聚合诱导相分离原理，通过将含巯基低聚物、含烯基低聚物、导电碳材料及致孔剂复配为低粘度墨水，通过对墨水聚合反应动力学和流变性质研究，结合光固化3D打印技术一步成型多尺度多孔结构。所述致孔剂兼具溶剂功能，降低墨水粘度并诱导微观孔隙生成，与宏观模型设计结合，形成多级孔隙网络。所得材料在智能传感、电磁屏蔽及水处理等领域展现出潜在应用价值。

一种3D打印构建骨肿瘤修复的压电骨支架的制备方法

Resumen de: CN120661733A

本发明公开了一种3D打印构建骨肿瘤修复的压电骨支架的制备方法，属于生物医用材料领域。所述方法通过3D打印构建骨肿瘤治疗修复的压电骨支架材料，具体包括以下步骤：均匀混合固定体积比的钛酸钡(BTO)和羟基磷灰石(HA)，通过光固化树脂，打印具有特定孔隙结构的生胚，随后经过脱脂、烧结、极化和后处理，制得BTO/HA压电复合骨支架。本发明制备得到的压电复合骨支架具有与骨缺损部位高度匹配的精确形状，同时可通过压电效应催化产生活性氧自由基，实现残留骨肿瘤细胞的高效原位灭活，将骨肿瘤治疗(压电抗肿瘤)和骨缺损修复(HA促骨化)两大功能集成于一体，提升治疗修复效果，改善患者的生活质量。

SACROPELVIC FUSION IMPLANT SYSTEM FOR PROVIDING A FOUNDATION FOR SPINOPELVIC FIXATION CONSTRUCTS IN ADULT SPINAL DEFORMITY SURGERY

Resumen de: US2025288424A1

A method of surgically treating a patient suffering from severe pain and disability of the low back and buttock by stabilizing the patient's spinal column to their pelvis with an implant system including surgical tools and an implant designed to prevent movement between the sacrum and the ilium while being able to attach to a spinal fusion rod which connect to pedicle screws implanted in the bones of the spine of the patient in order to offer lasting relief of the patient's symptoms. The system is designed to address complications in adult spinal deformity by optimizing spinopelvic fixation vis-à-vis the unique biomechanics of the SI joint. The sacropelvic system is a surgical solution which provides an additively manufactured implant at the base of the spine employing an S2AI trajectory while utilizing assisting technologies including surgical navigation and intraoperative neurophysiological monitoring.

3D PRINTED STRUCTURALLY SOUND PROSTHETIC SOCKET

Resumen de: US2025288423A1

A method for 3D printing a prosthetic socket from a digital model, including printing a solid wall perimeter of the prosthetic socket with a width achieved in a single pass of a printing nozzle, and forming a plurality of stiffener elements proximate a bottom end of the prosthetic socket, as a function of the printing the solid wall perimeter, is provided. Also provided is a 3D printed prosthetic socket including an upper portion, a lower portion configured to be attached to a prosthetic pylon, and a plurality of stiffener elements radially extending from the lower portion, wherein the upper portion, the lower portion, and the plurality of stiffener elements are printed as a solid wall construction comprised of a printing material deposited using only a single pass of a printing nozzle.

IMPLANT SYSTEM AND METHOD FOR JOINT FUSION

Nº publicación: US2025288331A1 18/09/2025

Solicitante:

ORTHOFIX US LLC [US]
Orthofix US LLC

Resumen de: US2025288331A1

Implant systems and methods treatment of a joint include a distal portion, a middle portion, and a proximal portion. The distal portion may include a thread having a first thread minor, a first thread major, and a first pitch. The distal portion also may have a reverse cut, helical fenestration formed through the thread. The middle portion may be devoid of threads and may include a porous outer surface structure to promote bony integration, the porous outer surface structure having a leading end and a trailing end, with the leading end having a diameter larger than the first thread minor. The proximal portion may include a proximal thread having a second thread minor, a second thread major, and a second pitch. The second thread minor may be substantially the same width as the trailing end of the middle portion.