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一种用于治疗糖尿病感染创面的负载碳点水凝胶微针及其制备方法

Resumen de: CN122681777A

本发明涉及一种用于治疗糖尿病感染创面的负载碳点水凝胶微针及其制备方法，首先制备功能化碳点QP‑CD‑2，随后基于所述QP‑CD‑2配置微针前驱液并进行光交联得到QP‑CD‑2@MNs。本发明制备的负载碳点水凝胶微针不仅具有高效的抗菌、抗氧化和抗炎活性，还具有重塑局部免疫微环境并促进创面快速且高质量再生的能力，具有良好的应用前景。

3D打印多孔钛合金产品的物理协同清洗方法、应用

Resumen de: CN122683138A

本发明公开了一种3D打印多孔钛合金产品的物理协同清洗方法、应用。该方法包括：S1、将待清洗产品浸入于超声波清洗装置中的清洗槽中，在20KHz～80KHz频率下超声处理5min～10min；S2、采用水流清洗单元，对超声处理后的待清洗产品的内部的孔隙进行物理冲刷；重复循环清洗流程至少两次，直至待清洗产品检测合格；循环清洗流程包括第一清洗流程和第二清洗流程，第一清洗流程为进行一次步骤S1的操作，第二清洗流程为进行一次步骤S2的操作。本发明通过超声处理与水流清洗单元协同，形成逐层深入的清洗效果，且该方法成本低廉且易于实施。

一种基于梯度蒸汽爆破的低分子量海藻酸钠制备方法及其应用

Resumen de: CN122685766A

本发明公开了一种低分子量海藻酸钠的制备方法、产品及其应用，属于生物高分子材料改性技术领域。本发明针对现有海藻酸钠降解法存在分子量分布宽、活性基团易破坏的技术问题，提供了一种"低温等离子体活化—梯度蒸汽爆破—负压重组"三级物理场耦合的制备方法。该方法包括：将海藻酸原料在含氧气氛中进行低温等离子体活化预处理；然后进行至少两级压力依次升高的梯度蒸汽爆破；再在负压环境下进行分子链重组；最后经中和、离心和干燥得到低分子量海藻酸钠。本发明制备的海藻酸钠重均分子量为20‑50kDa，分子量分布指数PDI≤1.5，1%水溶液透光率≥90%，可用于生物3D打印和药物控释载体。

具有集成读出的传感器阵列

Resumen de: TW202532824A

A deformable sensor array may include a plurality of sensors and a flexible substrate. Each sensor of the plurality of sensors may include a sensor die to generate an analog signal and an converter die to perform analog-to-digital conversion (ADC) of the analog signal to generate a digital output. The flexible substrate may include electrical interconnect coupled with the plurality of sensors, and strain relief cutouts between sensors of the plurality of sensors and between the electrical interconnect, to enable deformation of the plurality of sensors. Other aspects are also described and claimed.

一种基于先进生物打印技术辅助的声带修复装置

Resumen de: CN122681624A

一种基于先进生物打印技术辅助的声带修复装置，包括：成像定位部件，含内窥镜成像模块和三维重建处理器；手术操作部件，含声门暴露机构和象鼻式柔性机械臂，声门暴露机构暴露声门提供视野，机械臂高精度操作；生物修复部件，含微型打印头、相容性水凝胶、注射管及运动控制机构，实现声带重建与功能恢复。通过集成生物打印部件与成像定位部件，系统能够精确获取声带损伤区域的三维结构数据，并实现生物材料的毫米级精准沉积，使成像定位的毫米级精度、机械臂的微米级操作与生物材料的可控打印形成闭环反馈系统，提升声带修复的整体成功率，实现声带修复从"经验性操作"到"精准工程"的跨越，为声带功能障碍患者提供了更安全有效的治疗选择。

一种钛基超弹性形状记忆合金及其制备方法和应用

Resumen de: CN122687002A

本发明提供了一种钛基超弹性形状记忆合金及其制备方法和应用，属于合金技术领域。钛基超弹性形状记忆合金为TiMAlX合金，按照原子百分比计，M：29~41%，Al：18~26%，X：0.9~5.1%；其余为Ti和不可避免的杂质；其中，M为Zr和/或Nb，X为Mo、Ni、Fe、V、Cr、Mn或Ta中的一种或几种。本发明的钛基超弹性形状记忆合金中，混合焓较负的Al元素的含量较高，而且添加了特定的X元素作为强β稳定元素，在室温下，合金主要为B2母相；在外加载荷作用下发生应力诱导马氏体相变，形成B19马氏体相，从而产生可恢复变形。

髋臼杯假体以及髋臼杯假体的制备方法

Resumen de: CN122681627A

本发明提供了一种髋臼杯假体以及髋臼杯假体的制备方法，其中，髋臼杯假体包括：金属杯主体，具有内腔以及与内腔连通的开口，开口用于使关节柄假体的球头伸入至内腔内；陶瓷涂层，覆盖在内腔的内壁面上；羟基磷灰石涂层，覆盖在金属杯主体的外壁面上，其中，羟基磷灰石涂层包括叠置设置的多个第一层结构，由远离至靠近金属杯主体的方向上，多个第一层结构的钙磷比逐渐减小。本申请的技术方案能够有效地解决相关技术中的难以兼顾加工工艺和稳定性的问题。

一种3D打印碳纤维复合儿童下肢矫形器及其制备方法

Resumen de: CN122681633A

本发明涉及矫形器技术领域，公开了一种3D打印碳纤维复合儿童下肢矫形器及其制备方法，包括基底和侧连接架，基底和侧连接架采用3d打印一体成型设置，基底和侧连接架的外壁均粘接有碳纤维强化布，3粘接在基底、侧连接架的外壁后形成完整的矫形器，矫形器为贴合儿童下肢畸形轮廓的一体化薄壁壳体结构，本发明通过设置有采用薄壁3d打印基底加碳纤维布覆膜复合结构，摒弃传统矫形器厚壁补强的方式，基底壳体超薄设计，碳纤维层轻量化强化，整体厚度大幅降低，重量较传统矫形器减轻百分之四十至百分之六十，同时结构强度、刚性、抗冲击性大幅提升，不易变形开裂，解决现有产品轻薄度与强度无法兼顾的行业痛点。

一种基于3D打印的聚二甲基硅氧烷异质双层引导骨再生膜及其制备方法

Resumen de: CN122682109A

本发明属于生物医用材料与组织工程领域，涉及一种基于3D打印的聚二甲基硅氧烷异质双层引导骨再生膜及其制备方法。所述方法包括采用一步法合成镓掺杂锌基金属有机框架材料GZM和铜掺杂锌基金属有机框架材料CZM并进一步进行二氧化硅包覆改性，然后将改性填料制备为复合墨水，通过3D打印得到具有双层异质结构的膜材料。本发明的双层引导骨再生膜具备良好的机械支撑能力与柔性适配能力以及良好的抗菌性能与促骨再生能力。

METHOD FOR PREPARING CERAMIC SLURRY FOR PHOTOCURABLE 3D PRINTING

Resumen de: WO2026182384A1

The present invention relates to a method for preparing a ceramic slurry for photocurable 3D printing and, more specifically, to a method for preparing a ceramic slurry for photocurable 3D printing, in which ceramic or glass-ceramic powder is used such that a dental prosthesis can exhibit esthetics similar to those of a natural tooth and, furthermore, a non-reactive diluent is included so that a low-viscosity slurry can be prepared even while containing a high amount of the ceramic or glass-ceramic powder, wherein the slurry thus prepared is easily moldable using 3D printing, can be manufactured into a high-quality three-dimensional sculpture during 3D printing, has high precipitation stability during storage, and can maintain the viscosity even during a 3D-printing process.

METHOD FOR PRODUCING A NUTRACEUTICAL DELIVERY SYSTEM

Resumen de: US20260256181A1

The present invention refers to a method for producing a nutraceutical delivery system. The method comprises the steps of screen-printing a base paste, and curing the base paste. The method furthermore comprises the steps of screen-printing a first paste being separate to the base paste, and curing said first paste.

MATERIAL EXTRUSION 3D PRINTING PROCESS FOR BIODEGRADABLE MAGNESIUM ALLOY

Resumen de: WO2026182531A1

The present invention provides a 3D printing process for a magnesium alloy, comprising: a step of manufacturing an extrusion material comprising a magnesium alloy powder and a binder; a step of extruding the extrusion material so as to form a molded body; and a sintering step of sintering the molded body in a hydrogen-containing inert gas atmosphere. According to the process of the present invention, carbon by-products can be minimized during sintering and good interparticle bonding can be achieved, and thus a customized 3D-printed body having excellent physical properties can be provided.

3D Bioprinted Model for Quantifying Neurite Outgrowth

Resumen de: US20260258350A1

A three-dimensional (3D) bioprinted model of a forebrain cortex is designed to quantify neurite outgrowth across a hydrogel bridge. The 3D bioprinted model includes two cell-laden compartments formed using a first hydrogel matrix, separated by a hydrogel bridge formed from a second, stiffer hydrogel matrix. The model may fit within standard 96-well plate formats, enabling medium-throughput screening applications. The model was validated using Alzheimer's disease forebrain cortical populations, demonstrating significant reductions in neurite outgrowth from Alzheimer's disease populations compared to controls.

A NOVEL METHOD TO ALTER THE PROTEOME OF A DISEASED HEART BY INJECTION OF ECM PARTICLES PRODUCED FROM DECELLULARIZED 3D MICROTISSUES OF HUMAN MESENCHYMAL STEM CELLS

Resumen de: WO2026183490A1

This disclosure describes a method for altering the proteome of a diseased heart, organ or tissue by contacting it with extracellular matrix (ECM) particles derived from decellularized 3D microtissues. In an example, the process involves restoring the normal ratio of collagen levels, modulating immune responses, improving mitochondrial function, and/or mitigating the effects of TGF-Beta, a growth factor associated with fibrosis. The ECM particles can be produced from human mesenchymal stem cells and retain bioactive components and structural properties of native tissue. Additionally, the disclosure outlines a composition for treating a diseased organ using these ECM particles, which are treated to enhance crosslinking, stability, injectability, and compatibility with patients.

SYSTEM AND METHOD FOR OPTIMAL MAGNETIC RESONANCE EXAM WITH RETROSPECTIVE REFORMATTING WORKFLOW THAT LEVERAGES INTEGRATED GUIDELINES

Resumen de: US20260259290A1

A method includes receiving at a protocol optimizer an electronic medical record for the subject, wherein the electronic medical record includes a scan order for scanning a region of interest of the subject for a patient specific clinical indication with a magnetic resonance scanner. The method also includes utilizing the protocol optimizer to automatically access one or more initial protocols specific to the patient specific clinical indication from radiology guidelines and/or a protocol library. The method further includes generating with the protocol optimizer one or more optimized protocols from the one or more initial protocols for performing an acquisition including a three-dimensional (3D) acquisition of 3D image data of the region of interest of the subject, wherein the protocol optimizer is configured to reduce a number of scans for each contrast that is required by the patient specific clinical indication over the region of interest along multiple planes.

PREMATURE HEARTBEAT ANALYSIS

Resumen de: US20260256403A1

Systems and methods include approaches for calculating a relative timing value for respective beats associated with a rhythm classification, determining that respective relative timing values for a first set of the beats are within a first range of prematureness, and displaying time series cardiac data of the first set of the beats in a first window of a user interface.

SYSTEMS AND METHOD FOR LINKING COSMETIC LIP COLORS TO EMOTIONS

Resumen de: US20260256395A1

A computer system receives sensor data from sensors configured to measure a user's neurophysiological response to verbal stimuli in the form of an identified emotion presented to the user and visual stimuli in the form of cosmetic colors presented to the user via a user interface; displays representations of available cosmetic colors to the user; receives user input indicating selection of a candidate cosmetic color from among the available cosmetic colors displayed; displays to the user an avatar wearing a virtual cosmetic of the candidate cosmetic color; receives user rating data responsive to display of the avatar wearing the virtual cosmetic of the candidate cosmetic color; and determines whether the candidate cosmetic color is associated with the identified emotion based on the user rating data and the sensor data. The sensors may include brain activity, electrodermal activity, eye tracking, and/or heart activity sensors.

SYSTEMS, DEVICES, AND METHODS FOR DETERMINING FETAL WELLNESS USING FETAL ECG AND FETAL OXIMETRY INFORMATION

Resumen de: WO2026183135A1

Fetal electrocardiogram (ECG) information and fetal oximetry information may be used, in combination, to determine one or more indicators, or predictions, of fetal wellness, blood oxygen saturation, and/or heartrate. At times, the fetal ECG and fetal oximetry information may be input into a fetal health model to determine and/or predict fetal wellness and/or trends in fetal wellness over time. In some embodiments, the fetal ECG and fetal oximetry information may be obtained via a single, combined, device configured to obtain and/or measure the fetal ECG and fetal oximetry information via direct contact with a fetus. Additionally, or alternatively, fetal oximetry information may be measured via a transabdominal fetal oximetry sensor and/or transcervical device configured to be positioned in the vagina and contact the cervix.

INFORMATION PROCESSING DEVICE, INFORMATION PROCESSING METHOD, AND PROGRAM

Resumen de: WO2026182227A1

Provided is a technology enabling reduction of administrator burden and enabling timely response for prevention of heat stroke. 　A WBGT value acquisition unit 51 acquires a WBGT value from a WBGT measurement device 4. A worker site information acquisition unit 52 acquires, from an administrator terminal 2, elicited information such as physical condition when reporting to work, medical history, work intensity, clothing, and heat acclimatization, and acquires, from a portable worker terminal 3, vital information such as heart rate, blood oxygen saturation, and activity level. A correction value calculation unit 53 calculates a correction value through AI analysis. An individual worker reference value calculation unit 54 calculates a corrected WBGT reference value for each worker by using the correction value to perform an operation on a WBGT reference value. A heat stroke risk value calculation unit 55 calculates a heat stroke risk value from the difference between the WBGT value and the corrected WBGT reference value.

IMPROVED EVALUATION OF MEDICAL DEVICE RELATED DATA

Resumen de: WO2026180968A1

A method including executing an automatic evaluation of data residing on a computing system pertaining to a specific medical device. The method comprising obtaining access to a computing system, and via the computing system, obtaining access to data based on medical device settings and/or phenomena recorded in association with the medical device and executing an automated evaluation of the accessed data and gauging efficacy of the medical device based on results of the automated evaluation.

GEOGRAPHICALLY DISTRIBUTED DENTAL CARE MANAGEMENT SYSTEM FOR TREATMENT COORDINATION, TRANSPARENT ALIGNER FABRICATION, AND SPECIALIST COLLABORATION

Resumen de: WO2026181074A1

A system and method for managing dental treatment across geographically distributed clinics utilize a digital imaging module to capture intra-oral digital scans. A treatment planning module formulates a dental treatment plan validated by a remote orthodontic specialist. A patient management module orchestrates a competitive tender process to select an executing general dentist from a plurality of candidates based on weighted criteria comprising cost, proximity, and performance ratings. A manufacturing module interfaces with distributed laboratories for aligner fabrication. In some embodiments, the system incorporates a blockchain network with smart contracts for milestone-based financial execution and an artificial intelligence module for predictive treatment optimization. A real-time interactive aligner device comprising electromechanical micro-actuators enables remote geometric adjustments of the aligner in response to specialist instructions. A communication interface facilitates continuous feedback and oversight between patients, specialists, and selected providers, ensuring unified clinical quality and operational efficiency across the distributed network.

DIAGNOSING AND TREATMENT UVEAL MELANOMA

Resumen de: WO2026183498A1

The present disclosure relates to methods for diagnosing and treating uveal melanoma.

MACHINE LEARNING MODELS TO PREDICT GLAUCOMATOUS DAMAGE

Resumen de: WO2026183445A1

Presented herein are systems and methods of determining likelihoods of neurodegenerative vision loss in eyes due to glaucoma. A computing system may receive, for a subject at risk of neurodegenerative vision loss in an eye due to glaucoma, a dataset. The dataset includes a first biomedical image of the eye associated with the subject at a first intraocular pressure (IOP), a second biomedical image of the eye associated with the subject at a second IOP, and a plurality of characteristics associated with the subject. The computing system may apply a machine learning (ML) architecture on the dataset. The computing system may determine, based on applying the dataset to the ML architecture, a predicted metric in the eye of the subject. The computing system may generate, using the predicted metric, a score indicating a likelihood of neurodegenerative vision loss in the eye due to glaucoma.

APPARATUS AND METHODS FOR NEURAL STIMULATION USING POLYNOMIAL DISTORTION ALGORITHM

Resumen de: WO2026183411A1

Exemplary embodiments of the present disclosure include apparatus, methods and systems for therapeutic neuromodulation of neurons and circuits utilizing a polynomial distortion algorithm (PDA). Exemplary embodiments provide for selective activation of specific model neurons by PDA tuning of the stimulating waveform to the intrinsic biophysical properties of the neuron. Furthermore, exemplary embodiments provide energy optimization of the waveform that can minimize off-target effects. Selective activation of specific model neurons can be achieved by PDA tuning of the stimulating waveform to the intrinsic biophysical properties of the neuron. Furthermore, energy optimization of the waveform can minimize off-target effects. Apparatus and methods utilizing a polynomial distortion algorithm to stimulate neurons with different channel activation properties, channel conductance properties, and diameters are provided.

SYSTEMS AND METHODS FOR PRIORITIZING DIGITAL THERAPEUTIC CONTENT BASED ON COMPREHENSIVE ASSESSMENT TEST RESULTS

Nº publicación: WO2026183009A1 03/09/2026

Solicitante:

CLICK THERAPEUTICS INC [US]
CLICK THERAPEUTICS, INC.

Resumen de: WO2026183009A1

Presented herein are systems and methods for prioritizing digital therapeutic content based on comprehensive assessment test results. A computing system can maintain a patient profile for each patient of a plurality of patients including results data corresponding to a comprehensive assessment test testing across a plurality of domains. The computing system can maintain a plurality of task objects, each task object corresponding to at least one of the plurality of domains. The computing system can assign a rank to each domain based on the respective domain-specific result data. The computing system can generate a treatment plan including one or more task objects, wherein each task object is selected or arranged based on whether the task object corresponds to a group of domains. The computing system can provide data corresponding to the one or more task objects in accordance with the treatment plan.