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PROGRAMMABLE INTRAMEDULLARY IMPLANTS AND METHODS OF USING PROGRAMMABLE INTRAMEDULLARY IMPLANTS TO REPAIR BONE STRUCTURES

Resumen de: EP4606354A1

Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an intermedullary implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants are optimized for the expected stress applied at the bone structure site.

AN AQUEOUS BIOINK SOLUTION FOR USE IN LIGHT-BASED BIOPRINTING APPLICATIONS, AND METHODS OF USING THE AQUEOUS BIOINK SOLUTION

Resumen de: CN120091914A

The present disclosure relates to an aqueous bio-ink solution for light-based bioprinting applications comprising: (a) from 0.5% to 95% by weight of a water-soluble prepolymer; (b) from 0.001% to 5% by weight of a biocompatible metal acyl phosphinate photoinitiator; (c) from 0.001 wt% to 10 wt% of a biocompatible light absorber; and (d) from 5% to 99.5% by weight of a solvent. The present disclosure also relates to methods of using aqueous bio-ink solutions containing living cells and methods of using aqueous bio-ink solutions free of living cells (cell-free).

PROCESS FOR THE MANUFACTURING OF MICROSCALE HOLLOW METAL BODIES

Resumen de: WO2024083825A1

A hollow body and a process for preparing a hollow body having a bottom, an upper end wall and side walls extending between the bottom and the upper end wall, characterized in that the upper end wall and side walls are made of metal, the cavity within the hollow body has a volume in the range between 1 picoliter to 1,000 picoliter and the upper end wall comprises at least one opening. The hollow body are suitable for encapsulating small amounts of liquid, or of very small micro-electromechanical system, may be used for the controlled release of pharmaceutical components.

SYSTEMS AND METHODS FOR GENERATING DIRECTLY MANUFACTURABLE DENTAL APPLIANCES

Resumen de: CN120076767A

Systems, methods, and devices are provided for computer-aided design, digital treatment planning, and direct additive manufacturing of dental appliances. In some embodiments, a method includes receiving a treatment plan for teeth of a patient, the treatment plan specifying a target arrangement of teeth and a plurality of treatment stages to reposition the teeth from an initial arrangement toward the target arrangement. The method may include identifying appliance design parameters of one or more dental appliances for performing at least one of a plurality of treatment phases. The appliance design parameters may include one or more manufacturability parameters corresponding to an additive manufacturing process to be used for directly manufacturing the one or more dental appliances. The method may also include determining an appliance geometry of the one or more dental appliances using the set of appliance design parameters.

一种义齿3D扫描仪

Resumen de: CN223263037U

本实用新型涉及扫描仪技术领域，具体为一种义齿3D扫描仪，包括底座、固定架、放置台、安装架和扫描装置；固定架连接底座上端，安装架连接固定架，安装架设有滑轨，扫描装置滑动连接滑轨，扫描装置上设有限位组件，限位组件与安装架配合连接；底座转动设有用于调节放置台高度的升降机构，底座设有驱动机构传动连接升降机构，底座设有用于夹持义齿的夹持机构，夹持机构位于放置台的两端。本实用新型中通过转动的放置台和夹持机构使义齿可以全方面扫描，不需要多次调节提高扫描效率。

一种牙周辅助加速正畸手术专用导板

Resumen de: CN120531507A

本发明公开了一种牙周辅助加速正畸手术专用导板，该专用导板包括颊侧就位导板和合面就位导板、以及位于颊侧就位导板上的多个导向管，颊侧就位导板上设置有一体成型的定位销且合面就位导板上设置有一体成型的定位槽，合面就位导板套置在上颌和/或下颌的牙列上，与合面就位导板配套的颊侧就位导板上的定位销插入对应的定位槽内；所述的导向管位于牙列唇侧、牙龈软组织的外侧且排列在每个牙位的近中邻面和远中邻面处，导向管限定了支抗钉手柄工作头部的钻入位置、钻入方向和钻入深度。本发明导板使用后的创口为针状大小，患者不易出现术后水肿、强烈的炎症反应以及牙根吸收等情况，安全性强、操作方便、定位精准、费用便宜，适用于大多数正畸病例。

软组织重建植入物及其形成的方法

Resumen de: AU2025203084A1

Embodiments herein relate to an implant for insertion into a patient. The implant comprises a plurality of unit cells arranged to form a three-dimensional lattice structure, the three-dimensional structure comprising a resting volume of the implant. The plurality of unit cells are arranged to form a porous network of the three-dimensional structure, and wherein the three-dimensional structure is a reversibly compressible three-dimensional structure, wherein a bulk porosity of the three-dimensional structure (101) of the implant is at least 50 %.

一种耐蚀高超弹性增材制造镍钛合金及其制备方法与应用

Resumen de: CN120536767A

本发明公开了一种耐蚀高超弹性增材制造镍钛合金及其制备方法与应用。所述制备方法包括增材制造成型、前处理、表面处理三个步骤。本发明采用纳秒脉冲激光重熔的方法，利用特定范围内参数优化了增材制造镍钛合金表面质量，通过纳秒脉冲激光重熔工艺的精确热物理调控，重熔层形成了细小均匀的等轴晶粒结构，而基层则保留柱状晶粒，提高了整体超弹性效应；并促使其在腐蚀过程中形成稳定的钝化膜，有效抑制基体镍释放，提高了其耐蚀性。本发明所述制备方法具有精确可控、加工效率高和适用性广的优点，适宜推广应用。

动态水凝胶组合物

Resumen de: AU2023375461A1

Compositions and methods for delivery of therapeutic agents to an individual in need thereof, for prevention/reduction of tissue adhesion, and for 3D printing are disclosed herein. In some embodiments, the composition comprises octadecyl modified hydroxypropyl methylcellulose (HPMC-C18) and a surfactant or cyclic polysaccharide, wherein the composition is a hydrogel that exhibits dynamic properties.

正畸放置装置及其制造方法，口腔装置及其制造方法

Resumen de: EP4537787A2

Strategies that reduce shrinkage and ultimately warping of parts that are directly fabricated from photopolymer resins. This increases the accuracy of directly fabricated parts, which is essential for patient specific applications. Implementing these strategies can reduce the need for directly fabricated parts to have supporting structures, which can reduce pre-processing and post-processing steps and facilitate an easier route for production level scale of additive manufacturing.

联结部件、流道连接机构和喷墨记录装置

Resumen de: CN120534078A

本发明提供联结部件、流道连接机构和喷墨记录装置。联结部件包括：阀箱体；以及中空可动阀，配置在阀箱体的径向内侧，相对于阀箱体可在轴向上移位，通过在联结部件和其他联结部件被连接的连接状态时和连接被解除的连接解除状态时使中空可动阀相对于阀箱体的轴向的位置移位，从而中空可动阀在连接状态时使液体流通，而在连接解除状态时限制液体的流通，在连接状态时，在径向上的中空可动阀的预定部分与阀箱体之间产生间隙，中空可动阀具有在径向上贯通预定部分的流通口。

一种基于多模态神经网络的口腔3D建模打印方法、系统及相关装置

Resumen de: CN120531488A

本申请提供一种基于多模态神经网络的口腔3D建模打印方法及系统，属于口腔医学技术领域，首先基于图像传感器获取目标视频，将目标视频输入训练好的第一神经网络模型，基于第一神经网络模型的输出结果，确定强磨合区域数据，最后，获取初始模型数据，将初始模型数据与强磨合数据输入训练好的第二神经网络模型，基于第二神经网络模型的输出结果，确定目标建模数据。本申请实施例提出的一种基于多模态神经网络的口腔3D建模打印方法及系统，通过动态视频中运动数据驱动3D打印模型的咬合面形态设计，在正畸治疗的过程中预判组织变化，用历史病例训练预测网络，较人工测试咬合更精准，通过预测高磨损区域并提前增材设计降低牙冠碎裂或种植体松动率。

一种3D打印个性化骨骼夹板外固定装置及其制作方法

Resumen de: CN120531544A

本发明公开了一种基于3D打印的个性化骨骼夹板外固定装置及其制作方法，属于医疗器械技术领域。本发明包括固定主体及紧固件螺丝螺栓。所述固定主体可分为两部分，每部分纵向均设有四个调节部位。调节部位包括尼龙螺丝、尼龙螺母和底座，尼龙螺丝贯穿上下两夹板的底座连接螺母，通过旋转螺母调节夹板的松紧。所述外固定手臂夹板主体呈多边形不规则镂空状，保证了其具有较好的透气性。所述外固定手臂夹板由3D scanner扫描建模并测量具体数据，利用熔融沉积型3D打印机制成。其中3D打印机参数设置如下：控制打印喷头温度为190~220℃，打印底板温度为20~50℃，打印速度为20~40mm/s，冷却风扇转速为2000~2500rpm。打印机所使用的线材由超高分子量聚乙烯通过单螺杆挤出机制成。采用超高分子量聚乙烯保证了所述外夹板具有较高的抗冲击性能，固定效果好，有利于患者部位的稳定愈合。

一种用于后巩膜加固的光敏树脂及其制备方法与应用

Resumen de: CN120535735A

本发明公开了一种用于后巩膜加固的光敏树脂及其制备方法与应用。其制备方法包括以下步骤：将碳酸乙烯酯与异佛尔酮二胺混合反应生成非异氰酸酯聚氨酯；向非异氰酸酯聚氨酯加入己内酯，反应得到聚己内酯基聚氨酯二醇；在聚己内酯聚氨酯二醇溶液中添加三乙胺，再添加甲基丙烯酸酐进行反应，纯化，得到聚己内酯基聚氨酯光敏树脂。制得的聚己内酯基聚氨酯光敏树脂具有良好的生物相容性和力学性能，应用于后巩膜加压手术中，对后巩膜加压效果良好，OCT结果显示出现明显加压嵴。

数字化和柔性压力传感器结合的大腿假肢接受腔优化制造方法

Resumen de: CN120531531A

本发明公开了一种数字化和柔性压力传感器结合的大腿假肢接受腔优化制造方法。大腿残肢物理模型的数字化重建；对重建后的残肢构面数字模型空间标定和尺寸校准处理；对空间标定和尺寸校准后的残肢构面数字模型稀疏化处理并进行编辑和优化；将稀疏点云数字模型和帽檐、坐托的数字点云模型进行拼接成大腿假肢数字模型；设置柔性压力传感器压力分析调整局部片段厚度，生成外层表面形成双面稀疏点云的假肢接受腔数字模型，最后转换进行3D打印。本发明利用柔性传感单元与数字化皮肤上的点云单元相对应，进行静态和动态下肌肉受力的实时变化评估，能够在再次检查时能够快速适应患者的生理变化，提供更为个性化和及时的康复解决方案。

一种熔融沉积3D打印的医疗支具

Resumen de: CN120531540A

本发明涉及一种熔融沉积3D打印的医疗支具，用于医疗的器具，它公开了在医疗支具的全封闭的镂空区域、半封闭的镂空区域、底座承托的镂空区域内都填充有支撑薄片，使医疗支具与支撑薄片一体成形，在医疗支具的非镂空区域阵列设置有水滴形状的通孔。本发明的优点是它能满足医疗支具3D打印支撑需求的同时，后期拆除容易，而且支撑薄片拆除对支具表面质量影响小，确保复杂结构的医疗支具与支撑薄片一体成型，使医疗支具内外表面及整体曲面造型质量更加高。

熔融电写组织支架

Resumen de: AU2023365980A1

A melt electrowritten soft tissue scaffold, comprising: a first region having one or more sets of fibres and a second region having one or more sets of fibres; and an interface region joining the first region and the second region, the interface region being electrowritten along with the first and second regions in a continuous printing path, such that fibres in the interface region each join between a respective pair of fibres in the first and second regions.

用于脑血管屏障开放的治疗超声波处理系统及用于脑血管屏障开放的治疗超声波处理系统的超声波控制方法

Resumen de: WO2024172411A1

The purpose of the present disclosure is to provide a patient-customized helmet and a control method therefor, the helmet enabling the injection of an ultrasound contrast agent (e.g., microbubbles) into blood vessels of a patient and the radiation of ultrasonic waves into the brain by means of an ultrasound module to open the blood-brain barrier and deliver a brain disease therapeutic agent to the affected area.

一种基于3D打印技术的颈部理疗护具

Resumen de: CN120514526A

本发明提供了一种基于3D打印技术的颈部理疗护具，属于医疗器械领域，所述护具由如下的部件组成：后颈托壳体、护具内衬、双震动马达、温控加热装置以及操作控制模块。所述后颈托壳体选用PLA可降解线材，创新性地融合3D打印技术与按摩理疗功能，为颈部健康护理带来全新解决方案。护具整体通过3D打印成型，能够依据个体颈部的精准扫颈部理疗护具则提升与皮肤接触的舒适度，并适应颈部日常活动。本颈部理疗护具在颈部保健、慢性颈部疾病辅助治疗以及颈部疲劳缓解等方面具有显著优势，为用户提供便捷、高效、个性化的颈部护理服务，具有广阔的市场应用前景。

一种负载镁锰掺杂空位氧化铋的生物墨水及其制备方法、生物打印支架和应用

Resumen de: CN120514920A

本发明公开了一种负载镁锰掺杂空位氧化铋的生物墨水及其制备方法、生物打印支架和应用，该生物墨水包括以下质量体积百分比（mg/mL）的组分：5%~15%的苯硼酸接枝甲基丙烯酰化明胶、1%~10%的聚乙烯醇、0.15%~0.3%的苯基(2,4,6‑三甲基苯甲酰基)磷酸锂、0.01%~1%的负载镁锰掺杂空位氧化铋，该生物墨水通过3D打印制备生物打印支架。本发明利用苯硼酸接枝甲基丙烯酰化明胶和聚乙烯醇为基础生物墨水材料，同时负载镁锰掺杂空位氧化铋，由其制备的生物打印支架具有良好的生物学功能，可以作为老年性骨缺损修复的骨植入物，具有重要的临床应用价值。

用于气溶胶化液体的设备

Resumen de: WO2024133585A1

The present invention provides a nebuliser (100) comprising one or more inputs (110), and a plurality of droplet ejectors (126) in fluid communication with the one or more inputs (110). Each droplet ejector comprises a nozzle portion and a piezoelectric actuator. The one or more inputs are for receiving one or more liquids. Each nozzle portion defines a nozzle outlet in fluid communication with the one or more inputs. Each piezoelectric actuator is operable to cause ejection of a liquid received by one of the one or more inputs through the respective nozzle outlet as one or more droplets to thereby generate an aerosol comprising the one or more droplets ejected by each droplet ejector.

基于埃洛石纳米管的载药海藻酸钠水凝胶抗菌支架、制备方法及其应用

Resumen de: CN120514917A

本发明涉及基于埃洛石纳米管的载药海藻酸钠水凝胶抗菌支架、制备方法及其应用，属于材料合成和生物医药技术领域。所述支架是由载药埃洛石纳米管、海藻酸钠和甲基纤维素混合依次经3D打印、交联后得到的具有一定孔隙率和孔径结构的支架，载药埃洛石纳米管包埋在海藻酸钠/甲基纤维素水凝胶，载药埃洛石纳米管是由聚乙烯亚胺修饰的埃洛石纳米管与带负电的广谱抗菌剂混合得到的。该支架兼具降解速率可控和生物相容性特点，适用于骨髓炎清创后的局部抗感染与骨再生治疗。

Methods and Devices for Improving Bone Healing

Resumen de: US2025262356A1

A method for treating a bone defect extending between a proximal bone structure and a distal bone structure of a patient may include resecting a region of bone between the proximal bone structure and the distal bone structure and encompassing the bone defect, positioning a biodegradable osteogenic scaffold within a biodegradable sleeve, coupling the biodegradable sleeve to a fixation member, positioning the biodegradable sleeve between the proximal bone structure and the distal bone structure, and attaching the fixation member to each of the proximal bone structure and the distal bone structure.

HYBRID BIOINK BIOMATERIAL

Resumen de: US2025262349A1

A biomaterial is provided. The biomaterial includes a methacrylated polymer-silver-containing bioactive glass (methacrylated polymer-AgBaG) in which the AgBaG is chemically coupled to the methacrylated polymer. The methacrylated polymer may include gelatin methacryloyl (GelMA). Methods of making and using the biomaterial are also provided.

HIERARCHICALLY POROUS SLIT3-RELEASING PLGA/HYDROXYAPATITE NANONANOCOMPOSITE SCAFFOLD VIA INDIRECT 3D PRINTING FOR BONE TISSUE ENGINEERING

Nº publicación: US2025262348A1 21/08/2025

Solicitante:

UNIV OF NORTH DAKOTA [US]
University of North Dakota

Resumen de: US2025262348A1

A polymeric scaffold for bone repair and regeneration includes a body comprising a biodegradable polymer matrix and nanoparticles dispersed in the biodegradable polymer matrix, and a polydopamine surface coating on the body. A method of forming a composite scaffold for bone tissue engineering includes preparing a solution comprising a biodegradable polymer and a plurality of nanoparticles in a solvent, applying the solution to a surface of a mold and drying the solution to form a polymer matrix having nanoparticles dispersed therein, removing the mold from the polymer matrix to form an intermediate scaffold, and applying a polydopamine coating to the intermediate scaffold to form the composite scaffold.