Alerta

NON-BRAIDED BIODEGRABLE FLOW DIVERTING DEVICE FOR ENDOVASCULAR TREATMENT OF ANEURYSM AND ASSOCIATED FABRICATION METHOD

Resumen de: US20260060688A1

A biodegradable flow diverting device (BFDD) that will regulate blood flow into an aneurysmal sac, act as a scaffold for endothelization at the neck of an aneurysm, and degrade after successful dissolution of aneurysm and remodeling of blood vessel. This BFDD and associated fabrication method have the following features: (1) This is a non-braided FDD. The pore shapes, sizes, architectures (especially at the inlet and outlet of the pores), pore densities and porosities can be controlled for the optimum performance depending on the blood vessel and aneurysmal morphologies from patient MRI images, (2) BFDD is developed on a rotary arm with programmable variable speed and diameter in conjunction with a micromotion stage (3) Fabrication system can take any material including blended/composite biomaterials by adjusting temperature of the electro-melt extruder/needle and (4) Fabrication system is compatible with CAM (computer aided manufacturing) software and able to operate based on the adapted G-code.

Membran und Membrankontaktor

Resumen de: DE102024125325A1

1. Die Erfindung betrifft eine Membran (1) für einen Membrankontaktor (2), die als eine zu einer Mittelebene (ME) spiegelsymmetrische hohle Röhrenstruktur aus verzweigten Röhren (3, 3', 3", 3''', 3'''') mit beidseits der Mittelebene (ME) mehreren zur Mittelebene (ME) parallelen Verzweigungsebenen (VE) ausgebildet ist, wobei die Wandungen der Röhrenstruktur stoffpermeabel und/oder energiepermeabel sind und wobei im Bereich (B) jeder Verzweigungsebene (VE) jede in Richtung zur Mittelebene (ME) erstreckte Röhre (3, 3', 3'', 3''') in mehrere zur Mittelebene (ME) erstreckte Röhren (3', 3'', 3''', 3'''') verzweigt und die von beiden Seite der Mittelebene (ME) von der jeweils letzten Verzweigungsebene (VE) zur Mittelebene (ME) erstreckten Röhren (3'''') im Bereich (ÜB) der Mittelebene (ME) ineinander übergehen. Die Erfindung betrifft weiterhin einen Membrankontaktor (2) mit einer solchen Membran und ein Verfahren zur Herstellung einer hohlen Membran (1).

Resektionsschablone und Verfahren zum Rekonstruieren einer knöchernen Anatomie mit einer solchen Resektionsschablone

Resumen de: DE102024125227A1

Resektionsschablone (1) zum Rekonstruieren einer knöchernen Anatomie aus einem Transplantat (2), mit zumindest einem Segment (10), und mit zumindest einem Einsatz (12), welcher jeweils mindestens eine Bohrhülse (13) zum Vorgeben einer Position einer Bohrung im Transplantat (2) aufweisen; das zumindest eine Segment (10) einen Hauptkörper (HK), mindestens zwei im Hauptkörper (HK) angeordnete Löcher (14), und im Hauptkörper (HK) ausgebildete erste und zweite Aussparungen (15) aufweist, wobei die Aussparungen (15) zum Einsetzen von dem zumindest einem Einsatz (12) an einer vorgegebenen Position im Segment (10) vorgesehen sind, sowie Verfahren zum Rekonstruieren einer knöchernen Anatomiemit einer solchen Resektionsschablone (1).

PROCESS FOR THE MANUFACTURING OF MICROSCALE HOLLOW METAL BODIES

Resumen de: US20260060925A1

A hollow body has a bottom, an upper end wall, and side walls extending between the bottom and the upper end wall. The upper end wall and side walls are made of metal. The cavity within the hollow body has a volume in the range between 1 picoliter to 1,000 picoliter. The upper end wall comprises at least one opening. The hollow body is suitable for encapsulating small amounts of liquid, or a small micro-electromechanical system, and may be used for the controlled release of pharmaceutical components.

METHOD FOR OBTAINING A POROUS INJECTABLE SCAFFOLD BASED ON SIMILAR BIOPOLYMERS, BUT WITH DIFFERENT MELTING TEMPERATURES

Resumen de: US20260061094A1

Method for generating a porous injectable scaffold that includes providing a liquid composition of 2 phases at a temperature below 25° C., of Newtonian behavior, where the composition comprises: a liquid dispersant phase at room temperature formed by a gelatin with a low melting point, less than 15° C., functionalized with methacryloyl or methacrylamide groups; and a photoinitiator;and a dispersed phase, of microdroplets or beads in solid state, of a gelatin solution with a melting point greater than 25° C.; initiating the polymerization of the dispersing phase by light radiation; raising the temperature to 35-40° C. and allowing melting of the dispersed phase; and obtaining a porous scaffold. The formed porous scaffold and its use as a biological support for tissue regeneration/generation; as a biological matrix as a support for cells, for cell invasion; as an acellular biological matrix, a biological matrix as a mechanical support and/or a biological matrix for active components.

METHOD FOR PRODUCING A DENTAL ARCH MODEL, DENTAL ARCH MODEL, AND ARRANGEMENT

Resumen de: WO2026046865A1

The invention relates to a method for producing a dental arch model (100) intended to be detachably arranged on an articulator plate (300) of an articulator (1), and to a corresponding dental arch model (100) and to an arrangement comprising such a dental arch model (100). The dental arch model (100) is manufactured by 3D printing and comprises a model base plate (200) formed in one piece therewith, wherein the model base plate (200) has a number of recesses (220) which each have a bearing surface (225) in the form of a concave spherical-segment surface and which correspond to a number of projections (320) that are provided on the upper side of the articulator plate (300) and each have a bearing surface (325) in the form of a convex spherical-segment surface, and the recesses (220) on the model base plate (200) are designed such that the produced dental arch model (100), when arranged on the articulator plate (300), rests exclusively with the bearing surfaces (225) in the form of a concave spherical segment surface on the bearing surfaces (325) in the form of a convex spherical segment surface at the articulator plate (300), and the model base plate (200) and the articulator plate (300) are otherwise spaced apart from one another.

PATIENT-SPECIFIC NEURAL IMPLANTS ENGINEERED VIA 3D PRINTING TECHNOLOGY

Resumen de: WO2026049910A1

Embodiments relate to bioelectrodes designed to accommodate patient specific gyral patterns, and to methods of making and using thereof. A bioelectrode may be manufactured by obtaining a three-dimensional scan of at least a portion of a brain; identifying a target region of the brain; designing a bioelectrode model configured to fit the target region; and printing the bioelectrode based on the bioelectrode model. The bioelectrode is printed to include a top layer, a bottom layer, and an electrode layer positioned between the top layer and the bottom layer such that the top layer and bottom layer encapsulate the electrode layer. The bioelectrode may have a Young's modulus between 0.1 and 10 kPa to better mechanically match brain tissue.

WIRELESS MICROFLUIDIC SMART BANDAGE FOR EFFICIENT WOUND EXUDATE MANAGEMENT AND ANALYSIS IN HUMAN SUBJECTS

Resumen de: US20260060845A1

A wearable wound management system integrating a flexible microfluidic assembly and real-time electrochemical sensing to autonomously sample, transport, and analyze wound exudate. A Janus membrane, formed by selective deposition of perfluoroalkyl-functionalized silica nanoparticles and O2 plasma etching on a PET film, may collect fluid via its superhydrophobic wound-facing side and deliver it to a curved, wedge-shaped microfluidic channel that enhances capillary flow. Downstream, a graded PDMS micropillar array refreshes a sensing region by unidirectional fluid movement. A drop-on-demand inkjet-printed, CO2 laser-patterned flexible sensor patch may measure nitric oxide, oxygen, hydrogen peroxide, pH, temperature, and other relevant metrics. An encapsulated wireless electronic module may transmit health data for wireless monitoring. This system, combined with machine-learning analytics, may enable continuous, in situ monitoring and predictive wound classification, supporting proactive and personalized chronic wound care.

METHOD OF DESIGNING AND MANUFACTURING A CUSTOMIZED HAND PROSTHESIS

Resumen de: WO2024224174A1

A method for designing a functional prosthesis of customized hand, for patients amputated at trans-radial level, implemented with additive manufacturing technology. The method flow for designing and developing the devices consists of the following steps: i) kinematic analysis and 3D scan of the limb contralateral to the amputated one; ii) kinematic synthesis of the planar mechanism at one active degree of freedom (GdL), modular for each finger, and optimization of the same through a global performance index (GPI); iii) prototyping of the assembly of five fingers.

BAND WRAPPING DEVICE

Resumen de: WO2024226028A1

A band wrapping device forms a length of band material into a loop for automatically applying the band to a limb (e.g., wrist) of a user. The band wrapping device may receive the length of band material from a cassette receivable in the band wrapping device and can include a band transport mechanism for transporting the band material, a sealer module for sealing the band material to itself and cutting the band material to a length, and/or a ring module for reception of the limb of the user for band application. The device and its constituent components can help reduce the contact between the individual requiring a band and those applying the band, can help reduce waste by using a more precise amount of band material sized to the limb, and can help reduce the staffing requirements in areas in which the bands are to be applied.

METHOD FOR PRODUCING A COLLAGEN AND SILK POLYPEPTIDE COMPOSITE STRUCTURE

Resumen de: WO2024223794A1

The present invention relates to a method for producing a collagen and silk polypeptide composite structure. In addition, the present invention relates to a collagen and silk polypeptide composite structure and uses thereof.

临时修复体穿龈三维形态塑形工具盒及其制造方法

Resumen de: CN121587868A

本发明公开了临时修复体穿龈三维形态塑形工具盒及其制造方法。包括本体和塑形凹槽，塑形凹槽开设于所述本体上，塑形凹槽用于提供种植替代体的放置空间并模拟天然牙穿龈三维形态的结构；其中，本体包括上本体和下本体；上本体和下本体可拆卸连接；塑形凹槽包括种植替代体放置结构和穿龈轮廓成型结构，种植替代体放置结构与穿龈轮廓成型结构周边连接，种植替代体放置结构用于放置与种植体匹配的种植替代体，穿龈轮廓成型结构用于容纳与种植替代体相连接的临时修复基台，并模拟天然牙穿龈三维形态。

包括整体式模具主体的牙体修复模具

Resumen de: WO2025027496A1

A custom tool for forming a dental restoration in a mouth of a patient includes a one-piece mold body providing for a customized fit with at least one tooth of the patient, the one-piece mold body including an occlusal portion forming an occlusal surface corresponding with an occlusal surface of the tooth, a mesial proximal portion forming a mesial proximal surface corresponding with a mesial proximal surface of the tooth, and a distal proximal portion forming a distal proximal surface corresponding with a distal proximal surface of the tooth. The mold body is configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of the tooth. The occlusal portion, the mesial proximal portion, and the distal proximal portion are based on three-dimensional scan data of the mouth of the patient.

一种用于挤出3D打印的光-酸协同增强生物墨水及其制备方法

Resumen de: CN121592122A

本发明公开了一种用于挤出3D打印的光‑酸协同增强生物墨水及其制备方法。该墨水由N‑乙烯基吡咯烷酮（NVP）、聚乙烯醇（PVA）、光引发剂及具有“单羟基‑双羧基”特异结构的苹果酸组成。打印时，墨水经挤出并结合紫外光照射实现初步定型，随后在加热油性支撑浴中同步触发酸催化NVP深度聚合及PVA微晶化，一步完成光固化定型与热处理增强。本发明利用苹果酸独特的分子结构构建了高效的光‑酸协同增强机制，不仅显著提升了单体转化率，更通过物理‑化学双网络大幅增强了打印体的力学强度与形状保真度，有效解决了生物墨水可打印性与强度的矛盾，在组织工程、柔性电子等领域具有广阔应用前景。

一种人工血管打印方法及设备

Resumen de: CN121590022A

本发明涉及人工血管制造的技术领域，具体而言，公开了一种人工血管打印方法及设备包括：第一储液部件，用于储存芯相材料；第二储液部件，用于储存外相材料；同轴打印组件，具备同轴设置的内料管和外料管，内料管连接第一储液部件，外料管连接第二储液部件；压力源，连通第一储液部件和第二储液部件，用于提供压力；接收部件，设置于同轴打印组件下方，用于接收人工血管；光固化组件，设置于接收部件的一侧，用于固化人工血管；通过使用本发明，能够复现天然管状组织复杂的解剖学特征，能够防止微小血栓的产生；且能够有效避免造成微通道堵塞，避免影响制备精度和效率，能够兼顾血管结构的生物相容性和高机械强度。

一种基于甲基丙烯酰化明胶的微球、其制备方法及其在生物墨水中的应用

Resumen de: CN121588283A

本发明公开了一种基于甲基丙烯酰化明胶的微球、其制备方法及其在生物墨水中的应用，该微球以甲基丙烯酰化明胶为核心基材，可选择性复合糖胺聚糖‑甲基丙烯酰化明胶和/或脂质体，通过微流控技术制备而成，所得微球尺寸均一，且复合组分可赋予微球优异的自粘附特性；进一步采用微流控技术，以基材及复合组分作为微球壳相、细胞分散液作为微球核相，制备具有核壳结构的载细胞微球，该载细胞微球能良好维持包埋细胞的正常存活与生长。基于甲基丙烯酰化明胶的微球或载细胞的基于甲基丙烯酰化明胶的微球，可作为3D打印墨水用于制备支架材料、载细胞支架材料，适配细胞三维培养、细胞球培养、高密度细胞培养及组织工程植入材料领域。

包括整体式模具主体的牙体修复模具

Resumen de: WO2025027496A1

A custom tool for forming a dental restoration in a mouth of a patient includes a one-piece mold body providing for a customized fit with at least one tooth of the patient, the one-piece mold body including an occlusal portion forming an occlusal surface corresponding with an occlusal surface of the tooth, a mesial proximal portion forming a mesial proximal surface corresponding with a mesial proximal surface of the tooth, and a distal proximal portion forming a distal proximal surface corresponding with a distal proximal surface of the tooth. The mold body is configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of the tooth. The occlusal portion, the mesial proximal portion, and the distal proximal portion are based on three-dimensional scan data of the mouth of the patient.

一种3D打印用的医用级PEEK复合材料及其制备方法

Resumen de: CN121592153A

本发明公开了一种3D打印用的医用级PEEK复合材料及其制备方法，涉及3D打印技术领域，解决了现有PEEK材料存在的生物活性低的问题。该医用级PEEK复合材料由以下重量份的原料制成：聚醚醚酮基体80～95份、生物活性填料5～15份、界面改性剂0.5～5份、导热与成核增强剂0.1～3份；所述生物活性填料包括重量比为（1～5）:（5～1）的纳米羟基磷灰石和生物活性玻璃。能够有效模拟天然骨环境，提高复合材料的生物活性，促进细胞黏附与增值，从而提高细胞增值率，还能有效提高了复合材料的抑菌效果和力学性能。

一种降低裂瓷率的齿科用钴铬合金修复体3D打印工艺

Resumen de: CN121589301A

本发明的目的在于提供一种降低裂瓷率的齿科用钴铬合金修复体3D打印工艺，其中，钴铬合金粉末按重量百分比包括如下成分：Co：58‑64wt%；Cr：25‑31 wt %；Mo：5‑6 wt %；W：2‑3 wt %；Si：0.8‑1.2 wt %；Mn：0.5‑1.0 wt %；稀土氧化物：0.1‑0.3 wt %。打印工艺包括：采用如本发明所述的钴铬合金粉末预热、进行3D打印，打印过程中通过动态能量密度调制分别打印核心区、过渡区和表面区后获得修复体打印件，将钴铬合金打印件进行后处理获得钴铬合金修复体。本发明突破性结合粉末材料，3D打印工艺和后处理元素掺杂技术，显著提高金瓷结合力、实现金属与陶瓷的渐进式连接，从本质上解决界面失配问题。

一种具有生物相容性的低粘度树脂组合物及其制备方法和应用

Resumen de: CN121574312A

本发明提供了一种具有生物相容性的低粘度树脂组合物及其制备方法和应用，涉及临时牙冠树脂材料的技术领域。所述具有生物相容性的低粘度树脂组合物按重量份数计包括：丙烯酸酯树脂10~40份、活性稀释剂30~60份、改性填料10~50份、光引发剂0.5~2.5份、助剂0.5~5份；所述改性填料为钛酸酯偶联剂改性纳米填料，且所述钛酸酯偶联剂改性纳米填料包括纳米填料内核、以及包覆于所述纳米填料内核的表面的单分子钛酸酯偶联剂包覆层。本发明提供的临时牙冠用树脂组合物的粘度较低，流动性优异，利于材料打印成型；同时，保证了所制备的材料具有较好的生物相容性以及力学强度。

一种负泊松比结构多功能血管支架及其制备方法

Resumen de: CN121571655A

本发明公开了一种负泊松比结构多功能血管支架及其制备方法，涉及医疗器械技术领域，包括负泊松比结构的血管支架模型的构建、选区激光熔化增材制造、化学抛光处理以及表面仿生改性处理。该支架利用负泊松比特性能够更好地适应血管的变形，减少因变形不同步产生的不相容性，其结构圆润平滑，可有效避免传统支架锐利拐角处易产生的血流湍流与涡流，改善血流动力学性能，降低血小板激活与血栓形成的风险，通过制备表面梯度涂层，实现多机制协同，有利于支架表面内皮层的形成。

一种基于直接3D打印的无托槽隐形矫治器及其数字化设计与制造方法

Resumen de: CN121572585A

本发明公开了一种基于直接3D打印的无托槽隐形矫治器及其数字化设计与制造方法。该方法构建了一个数字化闭环流程：首先通过口内扫描与数字化排牙设定矫治目标；继而利用收缩包裹算法构建矫治器光滑包络空间；采用基于PointNet++的AI技术精准分割牙冠以界定力边界；通过厚度控制与边缘优化算法生成形态精确、力学稳定的矫治器数字模型；最后，基于DLP技术使用生物相容性树脂直接打印矫治器，并经过严格的二次固化等后处理确保其性能与安全。本发明省去了传统压膜工艺，从根本上消除了累积误差，并能通过工艺控制实现矫治器力学性能的个性化梯度设计，标志着隐形矫治技术从“形态匹配”迈向“功能适配”。

セラミックベニア及びセラミックベニアを作製する連続付加製造

Resumen de: CN120857914A

The present disclosure provides a method of making a ceramic article. The method comprises (a) obtaining a photopolymerizable slurry or sol comprising a plurality of ceramic particles distributed in the photopolymerizable slurry or sol, and (b) continuously moving a build substrate through the photopolymerizable slurry or sol using actinic radiation, and selectively polymerizing the photopolymerizable slurry or sol to form a gelled article. The method further includes (c) extracting a solvent from the gelled article to form an aerogel article or a xerogel article; (d) heat treating the aerogel article or the xerogel article to form a porous ceramic article; and (e) sintering the porous ceramic article to form a sintered ceramic article. The sintered ceramic article exhibits a specific density. In addition, additive manufactured ceramic articles exhibiting specific density, opacity, or both are provided.

辅助器打印方法、装置、电子设备、存储介质及计算机程序产品

Resumen de: CN120770988A

The invention discloses an artificial limb printing method and device, electronic equipment, a storage medium and a computer program product.The method comprises the steps that a first physiological data set of a first user is obtained; calling a first artificial intelligence model to process the first physiological data set to obtain a first constraint parameter set; the first artificial intelligence model is used for recommending a constraint parameter group based on an input physiological data group; the constraint parameter set represents constraints related to the mechanical performance requirements corresponding to the input physiological data set; taking the first constraint parameter group as a constraint, and calling a generative design algorithm to process the first physiological data group to obtain a first design parameter group; the generative design algorithm is used for generating a design parameter group meeting the corresponding comfort requirement on the basis of the input physiological data group, and the design parameter group comprises a plurality of design parameters of the artificial limb; and generating a first file based on the first design parameter group and the slice parameter group, and outputting the first file to the three-dimensional printing device.

数字化可无线传输的3D打印支具多参数监测系统及方法

Nº publicación: CN121572596A 27/02/2026

Solicitante:

武汉必盈生物科技股份有限公司

Resumen de: CN121572596A

本申请涉及医疗器械与智能健康监测技术领域，公开了一种数字化可无线传输的3D打印支具多参数监测系统及方法，旨在解决刚性支具与柔性传感器因弹性模量差异大而导致的界面应力集中、传感器易脱落及信号精度差的问题。该系统通过3D打印在支具内表面构建梯度互锁界面结构，并原位成型柔性多参数传感阵列，实现刚柔一体化；还包括嵌入式数据采集处理单元、无线传输模块及微型能源模块。该方法包括三维建模分区、梯度界面路径生成、多材料协同打印、信号同步采集融合及无线传输。本发明显著提升界面结合强度与监测精度，简化制造流程，支持个性化定制。