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微凝胶生物墨水、包含神经-血管网络的微凝胶支架及其制法和应用

Resumen de: CN120550196A

本发明提供了微凝胶生物墨水、包含神经‑血管网络的微凝胶支架及其制法和应用，属于生物医药技术领域。本发明制备得到的微凝胶生物墨水打印时具备显著自愈合能力，确保高精度挤出成型，剪切稀释能力优异，黏度随剪切速率增加显著降低；在生理温度下保持固态结构，具备温敏稳定性；自愈合效果显著，提升打印体机械稳定性，具有良好的打印挤出和成形能力。本发明实现了载神经元与血管内皮细胞微球的复合打印，成功构建了包含神经‑血管网络的微凝胶支架，能够用于模拟体内微环境互作机制，为复杂组织缺损修复提供一体化解决方案。

牙齿修复体制造的FEM分析

Resumen de: US2025268690A1

A method of building a dental restoration, including the steps of providing (S101) a three-dimensional data set indicating the spatial shape of the dental restoration and a spatial distribution of at least one production material within the dental restoration; simulating (S102) a spatial stress distribution within the dental restoration at a predetermined load based on the three-dimensional data set; and changing (S103) the three-dimensional data set based on the simulated stress distribution.

一种组织工程基质及其用途

Resumen de: CN120550195A

本申请提供了一种组织工程基质，其包括功能单元、微凝胶、光交联分子和生物活性分子，所述组织工程基质经紫外光光照后能够形成具有高细胞密度的可血管吻合植入的组织或器官。本申请中的组织工程基质由高密度功能单元、微凝胶、光交联分子和生物活性分子复合形成，可以同时满足生物打印要求的力学性能和生物活性，根据功能单元的类型可作为嵌入式打印墨水或挤出式打印墨水，构建形成的组织器官可用于药物开发与筛选、制备病理研究模型或者植入功能补偿病损的组织器官。

兼柱状晶向等轴晶转变和强塑性的钛氧铜合金及制备方法

Resumen de: CN120555818A

本发明涉及一种兼柱状晶向等轴晶转变和强塑性的钛氧铜合金及制备方法，该钛氧铜合金为Ti‑xCu‑yO，其中Cu占钛氧铜合金的重量百分含量比值为2.6≤x≤3.2，O占钛氧铜合金的重量百分含量比值为0.3

一种基于4D打印的多孔Niti合金仿生骨梯度结构构建方法

Resumen de: CN120551422A

本发明涉及医用植入物技术领域，具体是一种基于4D打印的多孔Niti合金仿生骨梯度结构构建方法，包括患者骨数据采集、仿生梯度模型设计、NiTi粉末制备、4D打印、热处理激活记忆效应、表面功能化处理、力学/生物性能测试，其特征在于：包括以下制备步骤：本发明，通过CT/MRI精准获取骨结构数据，结合Mimics预处理与UG/NX建模，针对皮质骨（低孔隙率30%‑40%）和松质骨（高孔隙率50%‑70%）差异化设计孔径与孔隙率，经ANSYS模拟典型载荷工况，使弹性模量（3‑15GPa）、抗压强度（80‑200MPa）接近天然骨，该设计显著降低植入体与宿主骨的弹性模量差，避免应力屏蔽导致的骨吸收问题，同时通过功率渐变技术实现孔隙率连续过渡，提升复杂载荷下的结构稳定性。

基于纤维蛋白原的重组蛋白

Resumen de: US2024294607A1

The present invention relates to isolated, recombinant polypeptides comprising the gamma chain of fibrinogen and a His-Tag. The present invention further relates to nucleic acids encoding said polypeptides, vectors comprising said nucleic acids, host cells, preferably bacterial host cells, comprising said nucleic acids or vectors, biohybrid materials comprising conjugates comprising said polypeptides, uses of the above, and methods for producing said polypeptides.

一种基于3D打印的苯巴比妥口崩微片及其制备方法

Resumen de: CN120549876A

本发明公开了一种基于3D打印的苯巴比妥口崩微片，主要由以下质量百分比的组分采用3D打印技术制备而成：苯巴比妥15％～70％，填充剂10％～60％，崩解剂0％～50％，矫味剂0.1％～2％，粘合剂0％～15％。本发明还公开了该苯巴比妥口崩微片的制备方法。所述的苯巴比妥口崩微片药物释放速度快，可提高患者服用药物的依从性，尤其方便婴幼儿等吞咽困难者服用。

RECOMBINANT HYBRID PROTEIN AND ITS USE

Resumen de: WO2025178505A1

The invention relates to a recombinant hybrid protein REC2z with a structure as defined in the description, recombinant DNA sequences encoding this protein, vectors containing the recombinant DNA sequences, and eukaryotic and prokaryotic expression systems using the in vitro recombinant DNA sequences described below. The invention also relates to the use of the recombinant hybrid protein REC2z as a component of bioink for bioprinting and also as a component of biomaterials. In addition, the invention relates to the use of recombinant DNA sequences, expression vectors and expression systems to produce the recombinant hybrid protein REC2z. The invention finds applications in bioprinting, medicine and cell and tissue engineering.

SYSTEMS AND METHODS FOR INKING A CATHETER BALLOON

Resumen de: WO2025179194A1

Systems and methods are provided for applying visualization features to one or more expandable members. In some embodiments, a modular rack system is provided that is configured to receive one or more expandable members. The modular rack system comprises one or more elongate rods assemblies, with each rod assembly being sized and shaped to receive a single expandable member. An inking system is configured to apply one or more visualization features on the one or more expandable members. The one or more visualization features are applied to each of the one or more expandable members such that each of the one or more expandable members has identical visualization features thereon.

HOLLOW EMBOLIC MICROSPHERE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

Resumen de: US2025269083A1

A hollow embolic microsphere, a preparation method, and a pharmaceutical composition and use thereof, wherein: the hollow embolic microsphere is a microsphere prepared using a polymer material and having a unique shape and structure, and is suitable for transcatheter arterial embolization. The hollow embolic microsphere of the present disclosure can enter channels having different sizes, and has embolization effects on various target positions. The hollow microsphere is internally porous and has drug loading abilities, and drug release when loading drug can be easily controlled and the treatment effect is good. No emulsifier or surfactant is needed in the preparation of the hollow microsphere, reaction conditions are mild, and the process is simple. The obtained microsphere has a uniform shape and a controllable size, and is capable of controlling the embolization time. Various drugs including protein heat-sensitive drugs can be loaded, and the drug encapsulation efficiency can reach more than 70%.

CONTINUOUS FIBER SUPPORT BARRIER FOR ENGINEERED VASCULAR NETWORKS

Resumen de: US2025269094A1

Disclosed herein are apparatuses comprising one or more channels defining a luminal space, wherein the luminal space is defined by an inner wall of fibrous basement membrane material, as well as methods of their manufacture and use.

Apparatus and Methods for Small Joint and Bony Defect Replacement

Resumen de: US2025268718A1

Apparatus and methods for joint and bony segment replacement may utilize additive manufacturing (e.g., 3D printing) of various anatomic constructs with PEEK/zeolite/ion (PZI) material. Heavy metal ion loading options may be utilized which may provide differing properties to different surfaces of the resultant apparatus. Moreover, using the PZI material, the apparatus being implanted in joint and bony segment replacement may favorably manipulate the biologic microenvironment in which it may be implanted. Further, through use of PZI material, current large joint replacement options also may be disrupted including, but not limited to, modifications of the joint replacement itself, and the augments and supporting joint reconstruction devices used in bone loss situations. Methods for joint and bony segment replacement may provide mixing two or more types of PZI material together through an additive manufacturing process; and introducing the mixture as part of an implantable apparatus.

FEM ANALYSIS FOR THE PRODUCTION OF DENTAL RESTORATIONS

Resumen de: US2025268690A1

A method of building a dental restoration, including the steps of providing (S101) a three-dimensional data set indicating the spatial shape of the dental restoration and a spatial distribution of at least one production material within the dental restoration; simulating (S102) a spatial stress distribution within the dental restoration at a predetermined load based on the three-dimensional data set; and changing (S103) the three-dimensional data set based on the simulated stress distribution.

Referenzkörper zum Bestimmen der Abschwächung von Röntgenstrahlung und Verfahren zu dessen Herstellung

Resumen de: DE102024105696A1

Die Erfindung betrifft einen Referenzkörper (1) zum Bestimmen einer Abschwächung von Röntgenstrahlung durch ein mittels Röntgenstrahlung untersuchtes Objekt, wobei der Referenzkörper (1) eine zusammenhängende Matrix (2) aus einem Kunstharz mit zugesetztem Röntgenkontrastmittel aufweist. Um einen Referenzkörper (1) anzugeben, welcher in einer Röntgenaufnahme sowohl eine hohe Röntgenkontrastauflösung, als auch eine hohe Ortsauflösung erlaubt, wird vorgeschlagen, dass die Matrix (2) 3D-gedruckt wird, wobei mindestens ein erster Bereich (3, 4, 5, 6,7) und ein zweiter Bereich (3, 4, 5, 6 7) der Matrix (2) definiert werden, indem das Röntgenkontrastmittel dem Kunstharz in dem ersten Bereich (3, 4, 5, 6, 7) in einer ersten definierten Konzentration und in dem zweiten Bereich (3, 4, 5, 6, 7) in einer von der ersten definierten Konzentration abweichenden zweiten definierten Konzentration zugesetzt wird, so dass der erste Bereich (3, 4, 5, 6, 7) einen ersten definierten Röntgenkontrast mit einer ersten CT-Zahl aufweist, welche sich von einer zweiten CT-Zahl eines zweiten definierten Röntgenkontrasts des zweiten Bereiches (3, 4, 5, 6, 7) um mindestens 1 HU unterscheidet.

SYSTEMS AND METHODS FOR RAPID LIQUID BIOPRINTING

Resumen de: US2025270502A1

Methods for fabricating three-dimensional (3D) constructs from a mixture of cells, culture medium, and a scaffold material with a controlled calcium chloride concentration is disclosed. The process involves positioning a nozzle within a gel composed of alginate solution. The nozzle is then moved within the gel, releasing the cell-media-scaffold mixture in a controlled pattern. As the mixture is deposited, it becomes surrounded by the gel, which provides structural support until it solidifies through the cross-linking reaction between the calcium chloride in the cell-media-scaffold mixture and the alginate solution. This results in the formation of a solid 3D structure that incorporates the cells and their supporting scaffold. The presented method offers a versatile platform for generating intricate cell-based 3D constructs with precise control over their composition and structure. This method can be used to produce cultivated meat with complex 3D structures as well as organelles and fully functional organs.

STRETCHABLE SELF-HEALING HYDROGEL

Resumen de: US2025270389A1

The present invention relates to a stretchable self-healing hydrogel. The hydrogel has excellent mechanical properties and stability, and stretchable and self-healing properties, and can be useful as a hydrogel for delivery of a drug or a cell, and a composition for 3D bioprinters.

COLLAGEN BIOMATERIAL DERIVED FROM ABALONE

Resumen de: US2025270291A1

The present invention is concerned with a manufactured article prepared from a biomaterial comprising isolated and purified type I collagen fibrils derived from abalone and a method of preparing such an article. The manufactured article can be prepared by 3D bioprinting, and therefore the present invention also envisages a novel bioink for a 3D bioprinter comprising an isolated and purified type I collagen fibril and cartridges containing such a bioink. The invention additionally relates to a method of isolating type I collagen fibrils from abalone. The manufactured article is useful in a number of biomedical applications including as an implantable device where it can function as a 3D bioprinted hard or soft tissue scaffold for tissue engineering.

COUPLING MEMBER, FLOW PATH CONNECTION MECHANISM, AND INKJET RECORDING APPARATUS

Resumen de: US2025269656A1

A coupling member includes a valve housing and a hollow movable valve. Relative to the valve housing, the hollow movable valve is positionally displaced in an axis direction between a position in a connected state where the coupling member is connected to another coupling member and a position in a disconnected state where the coupling member is disconnected from the other coupling member, thus allowing circulation of a liquid therethrough in the connected state, while restricting the circulation of the liquid therethrough in the disconnected state. In the connected state, a gap is generated between a prescribed part of the hollow movable valve and the valve housing in a radial direction. The hollow movable valve has a circulation opening penetrating through the prescribed part in the radial direction.

SYSTEMS FOR POST-PROCESSING ADDITIVELY MANUFACTURED OBJECTS WITH SENSOR FEEDBACK

Resumen de: US2025269599A1

Systems, methods, and devices for post-processing additively manufactured objects are disclosed herein. In some embodiments, a system includes a rotor configured to support a plurality of additively manufactured objects having excess material thereon. The system can further include an actuator configured to spin the rotor so as to remove the excess material from the plurality of additively manufactured objects. The system can further include a sensor configured to obtain sensor data indicative of a cleaning status of the plurality of additively manufactured objects while the plurality of additively manufactured objects remain on the rotor. The system can further include a controller configured to adjust, based on the sensor data, an operational parameter of the rotor that enhances removal of the excess material from the plurality of additively manufactured objects.

METHODS FOR 3D PRINTING OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS

Resumen de: US2025269585A1

Methods to fabricate objects by 3D printing of poly-4-hydroxybutyrate (P4HIB) and copolymers thereof have been developed. In one method, these objects are produced by continuous fused filament fabrication using an apparatus and conditions that overcome the problems of poor feeding of the filament resulting from the low softening temperature of the filament and heat creep along the fed filament. Methods using an apparatus including a heat sink, a melt tube, a heating block and nozzle, and a transition zone between the heat sink and heating block, with the melt tube extending through the heat sink, transition zone, and heat block to the nozzle are disclosed. 3D objects are also printed by fused pellet deposition (FPD), melt extrusion deposition (MED), selective laser melting (SLM), printing of slurries and solutions using a coagulation bath, and printing using a binding solution and polymer granules.

CONTINUUM ROBOTS FOR OMNIDIRECTIONAL 3D PRINTING AND RELATED PRINTING METHODS

Resumen de: WO2025179212A1

Many embodiments are directed to systems and methods for 3D printing. Many embodiments utilize a print head modeled after a concentric tube robot (CTR). Certain embodiments provide a print bed allowing for collaborative printing and can include ports to allow numerous degrees of freedom from a print head without loss of a print bed solution. Further embodiments allow printing within irregular print beds, including printing within an injection mold. Certain embodiments of print heads possess multiple nozzles and/or internal tubes to allow for additional geometries. Certain embodiments are directed to print nozzles allowing for multiple material printing, and optionally on-the-fly material switching. Certain embodiments are directed to uses of bioprinting, including in vivo printing of devices, while additional embodiments allow for pipeline type printing, such that the printed part continually and/or continuously moves through a path during the printing process.

SOCKET FORMING TOOLS FOR AUTOTRANSPLANTATION

Resumen de: WO2025178922A1

A socket preparation tool configured to facilitate autotransplantation of a donor tooth to a recipient site is provided. The socket preparation tool includes a tooth replica of the donor tooth. A coronal portion is optionally included for facilitating alignment of the tooth replica adjacent teeth during a simulated autotransplantation. A radicular portion includes a smooth surface configured to facilitate compression of soft bone or soft tissue of the tooth replica or a contoured surface adapted for filing or cutting bone of the tooth replica. A cylindrical attachment is configured to be coupled to the tooth replica, such as via a receiver. A method of guided autotransplantation of a donor tooth via the customized socket preparation tool includes at least fitting and adjusting the socket preparation tool coupled to the tooth replica in the recipient site, before extracting the donor tooth.

COUPLING MEMBER, FLOW PATH CONNECTION MECHANISM, AND INKJET RECORDING APPARATUS

Resumen de: EP4606583A1

A coupling member (1) includes a valve housing (12) and a hollow movable valve (101). Relative to the valve housing (12), the hollow movable valve (101) is positionally displaced in an axis direction between a position in a connected state where the coupling member (1) is connected to another coupling member (2) and a position in a disconnected state where the coupling member (1) is disconnected from the other coupling member (2), thus allowing circulation of a liquid therethrough in the connected state, while restricting the circulation of the liquid therethrough in the disconnected state. In the connected state, a gap (G) is generated between a prescribed part of the hollow movable valve (101) and the valve housing (12) in a radial direction. The hollow movable valve (101) has a circulation opening (1010) penetrating through the prescribed part in the radial direction.

POLYMERIC STRUCTURES HAVING A MICRO-VOID SPACE AND SYSTEMS AND METHODS FOR MAKING SAME

Resumen de: CN120225338A

Aspects of the present disclosure include methods for making polymer structures having microvoid spaces. A method according to certain embodiments includes irradiating a polymerizable composition positioned between a build lift table and a build surface to produce such polymerizable composition, the polymerizable composition has: a polymerized region of the polymerizable composition having a microvoid space in contact with a build lift table and a non-polymerized region of the polymerizable composition in contact with a build surface; removing the build lift from the build surface; contacting the generated microvoid space with a non-reactive composition; and repeating in a manner sufficient to create a polymer structure having a clearly discernible microvoid space. Systems for preparing polymer structures according to the subject methods are also described. Also provided are polymer structures having clearly discernible microvoid spaces, such as where the microvoid spaces are filled with a non-polymerizable composition.

PHOTOPOLYMERIZATION INITIATOR

Nº publicación: EP4606824A1 27/08/2025

Solicitante:

KJ CHEMICALS CORP [JP]
KJ Chemicals Corporation

Resumen de: EP4606824A1

An object of the present invention is to provide a photopolymerization initiator that is hardly affected by inhibition by oxygen, has good photoinitiating property in air, has high sensitivity to long-wavelength light, and can suppress odor and bleed-out problems of a cured product to be obtained.A photopolymerization initiator having one or more benzophenone groups and one or more saturated or unsaturated 5 or more-membered cyclic substituents having heteroatoms in a molecule, wherein one or more saturated or unsaturated 5 or more-membered cyclic substituents having heteroatoms are bonded to one or more carbon atoms of an aryl group of one or more benzophenone groups through a carboxylic acid ester group or a carboxylic acid amide group.