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Dissolvable Pore Reinforcement For Surface Overmolding

Resumen de: US20260256590A1

0000 A method of manufacturing an implant including additively manufacturing the implant from a first material such that the implant defines a plurality of pores. Then inserting a filler material into the pores after the implant has been manufactured. Next, overmolding the implant with a second material after the filler material has been inserted the pores, and then dissolving the filler material from the pores prior to deployment of the implant.

A MICROFLUIDIC DEVICE FOR MODELLING VASCULATURE ACTIVITY AND A METHOD OF FORMING THEREOF

Resumen de: WO2026178602A1

A patient-specific microfluidic device for modelling thrombotic response and method of making thereof. The device includes a flow channel having a geometry that substantially corresponds to a patient's vascular geometry in a region of interest, said geometry derived from one or more clinical images associated with the patient. The device includes endothelial cells lining at least a portion of the flow channel, and at least one portion of laser-induced injury corresponding to an identified injury site of the patient or a desired injury site for modelling.

COMPOSITIONS AND METHODS FOR TREATING KIDNEY DISEASES IN PETS

Resumen de: WO2026181069A1

Methods of culturing renal cells of pets are provided. Also provided are methods of producing spheroids and organoids from pet renal cells and uses thereof in regenerating renal function.

SYSTEMS AND METHODS FOR OPTIMIZED RETINAL IMAGE CAPTURE USING DUAL-STAGE AI-BASED QUALITY ASSESSMENT

Resumen de: WO2026183110A1

Disclosed in an integrated retinal imaging system designed to enable high-quality, diagnostic image capture with minimal operator intervention. The system can implement a dual-stage Holistic Quality Assessor (HQA), with HQA-1 performing real-time, holistic quality assessments on infrared or near infrared image frames to detect optimal capture conditions, and HQA-2 verifying the diagnostic adequacy of a captured color image. Both HQA-1 and HQA-2 can leverage machine learning or deep-learning models executed on a local hardware accelerator and are configured to provide low-latency and accurate evaluations. By combining dual-stage quality assessment with real-time capture optimization, the system can enable reliable, diagnostic-quality image capture across various clinical settings and user experience levels.

MODEL-RECEIVING BODY FOR FASTENING A JAW MODEL

Resumen de: WO2026180184A1

The invention relates to a model-receiving body (1) for fastening a jaw model (2) in an articulator (3), wherein: the model-receiving body (1) has a first side (4) for fastening the jaw model (2) and a second side (5) opposite the first side (4); the model-receiving body (1) has a plurality of bearing bars (6) for the jaw model (2) and a fastening device (7) for magnetically fastening the model-receiving body (1) to the articulator (3) or to an adapter plate (8); open spaces (9), which are open towards the first side, are formed between the bearing bars (6) in the model-receiving body (1), and the bearing bars (6) have bearing surfaces (10) for supporting the jaw model (2) in a first direction (11) pointing away from the second side (5); the model-receiving body (2) has at least two, preferably three, position-securing pins (12), which are arranged at a distance from one another and project beyond the bearing surfaces (10) in the first direction (11), for aligning the jaw model (2) in two directions (13, 14), which are orthogonal relative to the first direction (11) and also relative to one another.

THYMIC CELL COMPOSITIONS AND METHODS OF MAKING

Resumen de: US20260256842A1

0000 The present disclosure provides thymic cells, thymic organoids, and animal models comprising such thymic cells and thymic organoids. It also provides methods for inducing differentiation of pluripotent stem cells into definitive endoderm (DE), anterior foregut endoderm (AFE), ventral pharyngeal endoderm (VPE), thymic epithelial progenitor (TEP) cells, thymic epithelial cells (TECs) and thymic organoids in vitro and in vivo.

TABLET DISPENSER

Resumen de: US20260256654A1

0000 The present invention is directed to a tablet dispenser. The tablet dispenser includes: a discharge part sealing unit positioned beneath a plurality of tablet discharge devices each including a discharge part for discharging stored tablets, and provided with a plurality of openings; and a tablet collection module positioned beneath the discharge part sealing unit. When the discharge part sealing unit is moved in a first planar direction, it blocks the discharge parts to spatially separate the plurality of discharge parts from the tablet collection module. When the discharge part sealing unit is moved in a second planar direction opposite the first planar direction, it positions the openings in the same lines as the corresponding discharge parts to allow the plurality of discharge parts to spatially communicate with the tablet collection module.

ROBOTIC SURGICAL SYSTEM AND METHOD FOR USING ARTIFICIAL INTELLIGENCE TO GENERATE SIMULATION AND DECISION SUPPORT FOR TELEOPERATION

Resumen de: US20260256534A1

0000 A robotic surgical system and method for using artificial intelligence to generate simulation and decision support for teleoperation are provided. In one embodiment, the robotic surgical system provides a surgical simulation model with input about a surgical field of a patient and signals generated in response to user-manipulation of the plurality of user input devices to perform a surgical task on the patient. The surgical simulation model generates and displays a video that represents a simulated performance of the surgical task. Other embodiments are provided.

SYSTEMS AND METHODS FOR FABRICATING ORTHODONTIC RETAINERS

Resumen de: US20260256560A1

The present disclosure provides systems and methods for fabricating an orthodontic retainer comprising a retainer base. The methods may include obtaining a first digital model representing the palate and the upper teeth of a patient. The methods may include creating, based on the first digital model, a second digital model representing the retainer base and a third digital model representing a teeth shell, and creating, based on the second digital model and the third digital model, a fourth digital model representing the retainer base and the teeth shell that are connected via a connecting structure. The methods may include generating a printed assembly by printing the fourth digital model using a first curable resin material. The printed assembly may at least include the retainer base, the teeth shell, and the connecting structure. The methods may include post-processing the printed assembly to obtain the retainer base.

一体型モールド本体を含む歯科修復モールド

Resumen de: WO2025027496A1

A custom tool for forming a dental restoration in a mouth of a patient includes a one-piece mold body providing for a customized fit with at least one tooth of the patient, the one-piece mold body including an occlusal portion forming an occlusal surface corresponding with an occlusal surface of the tooth, a mesial proximal portion forming a mesial proximal surface corresponding with a mesial proximal surface of the tooth, and a distal proximal portion forming a distal proximal surface corresponding with a distal proximal surface of the tooth. The mold body is configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of the tooth. The occlusal portion, the mesial proximal portion, and the distal proximal portion are based on three-dimensional scan data of the mouth of the patient.

THERAPY FOR THE TREATMENT OF DISORDERS IN THE NERVOUS SYSTEM BY MEANS OF CLASSIFICATION OF DETECTED TREMORS THROUGH MACHINE LEARNING

Resumen de: US20260256423A1

A method includes receiving data for an episode stored by a medical device of a patient. The episode is associated with a period of time. The data includes an electroencephalogram or data derived from neural activity in the brain sensed by the medical device during the period of time. One or more machine learning models are applied to the data and are configured to output a respective likelihood value for each of a plurality of tremor type classifications. The method further includes, based on the application of the one or more machine learning models to the episode data, deriving, for each of the tremor type classifications, class activation data indicating varying likelihoods of the classification over the period of time; and displaying a graph of the varying likelihoods of the tremor type classifications over the period of time.

SECURE NETWORKED RESPIRATORY THERAPY SYSTEMS

Resumen de: US20260257029A1

Methods and apparatus provide communications among respiratory therapy device (“TD”), server and intermediary (e.g., a control device (“CTLD”) for the therapy device) to improve security. More secure communication channel(s) may be established using shared secrets derived with different channels. The communications may include transmitting therapy data from TD to server for authentication. The CTLD may receive the data and a nonce from a server. The CTLD receives from the TD a signing key dependent on the nonce and a secret shared by TD and server. The CTLD generates an authorisation code with received therapy data and the key for authentication of the data by the server upon its receipt of the code and data. The server computes (1) a key from the nonce and the secret known to TD, and (2) another authorisation code from received therapy data and the key. Data authentication may involve comparing received and computed codes.

CONVOLUTIONAL NEURAL NETWORK FOR IDENTIFICATION OF ANATOMICAL LANDMARK

Resumen de: US20260260476A1

A method for locating an anatomical landmark includes obtaining an ultrasound image of an anatomical area from an ultrasound imaging device and inputting the ultrasound image into a first stage of a convolutional neural network where the first stage configured to determine a key-point location of the anatomical area. The method also includes generating, for the key-point location, a cropped region of the ultrasound image and inputting the cropped region into a second stage of the convolutional neural network, where the second stage is configured to locate the anatomical landmark of the anatomical area. Then, outputting a location of the anatomical landmark.

SUBCUTANEOUS OUTPATIENT MANAGEMENT

Resumen de: US20260260730A1

A method of administering insulin includes receiving scheduled glucose time intervals and obtaining glucose data of a patient that includes glucose measurements, glucose times, and insulin dosages previously administered by the patient. The method also includes applying a set of filters to identify which of the glucose measurements associated with at least one of the scheduled time intervals are usable and which of the glucose measurements associated with the at least one scheduled time interval are unusable. The method also includes aggregating the glucose measurements associated with the at least one scheduled time interval identified as usable to determine a representative aggregate glucose measurement and determining a next recommended insulin dosage for the patient based on the representative aggregate glucose measurement and the insulin dosages previously administered by the patient.

Apparatus for monitoring, regulating, or controlling fluid flow

Resumen de: AU2026216825A1

An apparatus, system and method for regulating fluid flow are disclosed. An apparatus for infusing fluid into a patient includes a housing, a tube-contact member, a rotating arm, and a tube-retention cover. The housing has an opening on a front side of the housing. The opening is sized to receive a drip chamber having an inlet tube and an outlet tube. The tube-contact member contacts one of the inlet tube and the output tube of the drip chamber when inserted into the opening. The rotating arm is coupled to the tube-contact member and is configured to rotate along an axis. The tube-retention cover is configured to close when the drip chamber is initially loaded into the opening. tube and an outlet tube. The tube-contact member contacts one of the inlet tube and ug u g t u b e a n d a n o u t l e t t u b e h e t u b e - c o n t a c t m e m b e r c o n t a c t s o n e o f t h e i n l e t t u b e a n d

FUNCTIONALIZED RECOMBINANT BACTERIAL COLLAGEN-LIKE PROTEINS

Resumen de: US20260258096A1

Recombinant bacterial collagen-like protein, preferably with an amino acid sequence that is at least ≥60% identical to the amino acid sequence of SEQ ID NO:1 wherein the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO:1, wherein the recombinant collagen-like protein is functionalized with at least one non-terminal alkene group. A bioink comprising the functionalized recombinant bacterial collagen-like protein, at least one solvent and at least one photoinitiator, a process for producing a hydrogel by crosslinking the functionalized recombinant bacterial protein or the bioink as well as the hydrogel obtained therefrom. Furthermore, a scaffold for tissue engineering comprising the hydrogel.

MULTIMODAL SEIZURE SENSING

Resumen de: US20260256413A1

0000 This disclosure describes systems, apparatuses, and techniques that use of multiple sensing modalities (multimodal sensing) in parallel to improve the detection, classification, and evaluation of seizures in subjects (e.g., mammalian subjects, such as humans). In some implementations, a wearable device includes a flex sensor configured, an inertial motion unit (IMU), and a plurality of surface electromyogram (sEMG) electrodes configured to be placed approximate to a muscle of a subject. The device also includes a microprocessor. The operations performed by the microprocessor include determining multimodal movement data of the muscle, where the multimodal movement data specifies at least an acceleration associated with movement of the muscle, an angular velocity associated with movement of the muscle, and sEMG activity associated with the movement of the muscle. The operation further includes determining whether the multimodal movement data indicates a possible seizure, and provide data based on the determination for output.

SYSTEM AND METHOD FOR ADDITIVE MANUFACTURING USING AN OMNIDIRECTIONAL MAGNETIC MOVEMENT APPARATUS

Resumen de: US20260256701A1

0000 A process system and method for the making of articles, using an omnidirectional magnetic movement system with a transport surface and fabrication modules having a formation surface that can be transported omnidirectionally over the transport surface under the control of a movement controller. An article forming system provides process unit operations for forming articles onto the formation surface as the fabrication modules are moved asynchronously between a plurality of processing positions on the transport surface, and features a depositing device for placing a construction material onto the formation surface and one or more processing devices to form the construction material into the article.

METHODS AND SYSTEMS FOR PREDICTING TREATMENT OUTCOMES, PATIENT SELECTION AND PERSONALIZED THERAPY USING PATIENT RESPONSE PROPERTIES TO SENSORY STIMULATION

Resumen de: US20260256407A1

In some aspects, the present disclosure describes a method of predicting an expected treatment outcome of a subject, comprising administering a gamma oscillation-inducing non-invasive sensory stimulus to the subject, measuring a response from the subject, and predicting, using a machine learning algorithm, the expected treatment outcome of the subject based at least partially on the measured response. In some aspects, the present disclosure also provides methods for personalizing gamma therapy treatment by adjusting parameters associated with the gamma oscillation-inducing non-invasive sensory stimulus based on a subject's response to the gamma oscillation-inducing non-invasive sensory stimulus.

SYSTEMS AND METHODS FOR MONITORING PATIENT INTERFACES

Resumen de: US20260257027A1

In one form of the present technology, a system for analysing a high flow respiratory therapy, may comprise: a blower; a nasal cannula, wherein a flow of gas travels from the blower to the nasal cannula along a flow path during administration of the high flow respiratory therapy; a sensor disposed along the flow path; and a processor configured to perform steps to: receive data from the sensor; compare the data received from the sensor to a threshold value; based at least in part on the comparison, determine whether the nasal cannula is mispositioned on a patient or displaced from the patient; and upon determining the nasal cannula is mispositioned on the patient or displaced from the patient, transmit an alert indicating that the nasal cannula is mispositioned on the patient or displaced from the patient.

REINFORCED PROSTHETIC DEVICE

Resumen de: US20260256600A1

0000 The present invention is directed to a novel 3D printed prosthetic sockets having one or more internally positioned support struts configured to counter the structural instability at the distal ends of the socket and prevent undesired sheering forces that can result structural failure of the socket.

EVALUATION METHOD BASED ON ANALYTE DATA AND AN EVALUATION SYSTEM

Resumen de: US20260256430A1

0000 Some embodiments of the disclosure describe an evaluation system based on analyte data including a memory storing a program, a display, and a processor. In some examples, the processor is configured to: receive analyte data during a predetermined time period from an object to be tested, acquire a plurality of analyte indicators different from each other based on the analyte data, normalize the plurality of analyte indicators to a predetermined range to acquire a plurality of normalized analyte indicators, plot a polygon pattern corresponding to the analyte data during the first time period as a target polygon pattern, plot a polygon pattern corresponding to the analyte data during the second time period as a reference polygon pattern, and take a line segment between a vertex and a center point as an axis, and display the target polygon pattern and the reference polygon pattern.

SYSTEMS AND METHODS FOR MANAGING, MONITORING, AND TREATING PATIENT CONDITIONS

Resumen de: US20260260724A1

0000 Systems, devices, user interfaces, and methods for managing patient conditions. A system for monitoring and/or managing a patient suffering from a brain condition may include a controller obtaining and/or storing data related to one or more monitored patient parameters contributing to the brain condition of the patient and displaying values of the one or more monitored patient parameters in trend lines over time on a user interface. The displayed trend lines may represent values of ventricular CSF volume, values of IVH volume, total ventricular volume in the brain, and/or values of other suitable parameters. The data related to the one or more monitored patient parameters may include images of the patient’s brain and/or data derived from images of the patient’s brain and/or suitable patient data.

PATIENT-SPECIFIC VERTEBRAL IMPLANTS WITH POSITIONING FEATURES

Resumen de: US20260256591A1

0000 The present technology provides patient-specific vertebral implants. The implants can include a cage having a geometry contoured to mate with an inferior surface of a superior vertebra and a superior surface of an inferior vertebra at a first target position. The implants can also include a plate having a geometry contoured to mate with an identified anatomical structure at a second target position. The cage and plate can be coupled in a predetermined three-dimensional orientation that simultaneously permits the cage to occupy the first target position and the plate to occupy the second target position when the implant is implanted.

IMPLANTABLE NEURO MODULATOR DEVICE AND SYSTEM COMPRISING SUCH AN IMPLANTABLE NEURO MODULATOR DEVICE

Nº publicación: US20260257071A1 03/09/2026

Solicitante:

NEUROGYN AG [CH]
NeuroGyn AG

Resumen de: US20260257071A1

An implantable neuro-modulator device, including a hermetically sealed housing, wherein an antenna for communicating with external devices and/or for wirelessly receiving electrical energy is positioned within the housing, wherein a major part of the housing is electromagnetically transparent to radiation in the frequency range below 20 MHz, in particular between 5 and 15 MHz.