Alerta

NORBORNENE-MODIFIED DECELLULARIZED EXTRACELLULAR MATRICES AND METHODS OF MAKING AND USING THE SAME

Resumen de: US2025262351A1

A composition comprising decellularized extracellular matrices, hydrogels comprising the same, and methods of making the same are disclosed.

ORAL DRUG DOSAGE FORMS HAVING A DESIRED PK PROFILE AND METHODS OF DESIGNING AND PRODUCING THEREOF

Resumen de: US2025262164A1

The present disclosure, in some aspects, is directed to methods of designing an oral drug dosage form formulated and configured to have a desired pharmacokinetic profile. In other aspects, the present disclosure is directed to oral drug dosage forms having a desired pharmacokinetic profile, and methods of making, such as three-dimensional printing, such oral drug dosage forms.

ORTHODONTIC ALIGNER QUALITY ASSESSMENT

Resumen de: US2025265713A1

A method includes receiving a digital representation of an orthodontic aligner, analyzing the digital representation of the orthodontic aligner to identify a quality-related property of the orthodontic aligner, determining, based on the quality-related property, that the orthodontic aligner comprises a manufacturing flaw, and causing the orthodontic aligner to be remanufactured responsive to determining that the orthodontic aligner comprises the manufacturing flaw. Analyzing the digital representation includes comparing the digital representation of the orthodontic aligner with data based on a digital model of a dental arch associated with a stage of treatment to be performed using the orthodontic aligner, and calculating one or more differences between a feature determined from the data and a feature of the digital representation of the orthodontic aligner.

METHODS OF PRODUCING PRINTED CONSTRUCTS AND USING THE SAME

Resumen de: US2025262355A1

Described are methods for producing tissue constructs, tissue constructs produced by the methods, and their use. The described method of producing a tissue construct comprises providing a granular tissue, depositing one or more filaments on or in the granular tissue, each filament comprising an ink, and gelling or fusing the granular tissue, thereby producing the tissue construct.

3D SUBTRACTIVE MANUFACTURING OF CASTS, BRACES, SPLINTS AND OTHER ORTHOSES

Resumen de: US2025262077A1

A three-dimensional subtractive manufacturing system configured for constructing an orthopedic orthosis from a first blank of a plurality of blanks includes a scanner configured to capture a 3D model of a body part of a patient, a central processor configured to receive the 3D model and select the first blank based on the three-dimensional model and a computer numerical control machine configured to receive the computer numeric control programming file and an identification of the first blank from the central processor. The central processor is configured to convert the 3D model into a CNC programming file. The CNC machine comprised of a subtractive manufacturing machine. The CNC machine configured to remove material from the first blank to form the orthopedic orthosis.

SURGICAL TOOLS FOR IMPLANTING A TISSUE SCAFFOLD

Resumen de: WO2025174829A1

A surgical tool kit and a method of installing a tissue, the method comprising positioning an alignment guide to ensure proper alignment of surgical tools relative to a lesion in a host tissue; inserting a guide pin into the host tissue to provide a reference point; using a punch to score the host tissue at the location of the guide pin; utilizing a cannulated reamer to prepare a socket in the host tissue; evaluating the prepared socket in the host tissue with a trial implant to ensure proper fit and alignment; employing an undercut tool to prepare at least one groove in the host tissue; and placing the tissue scaffold into the prepared socket using an insertion tool.

INJECTION-MOLDED PARTIAL DENTURE APPLIANCES

Resumen de: WO2025175303A1

A method according to the disclosure herein includes producing, via additive manufacturing, a first mold portion having a first recess based on a tooth portion of a patient mouth; producing, via additive manufacturing, a second mold portion having a second recess based on a gum portion of the patient mouth; positioning at least one artificial tooth in the first recess; aligning the first mold portion with the second mold portion to form a mold assembly having a cavity defined by the first recess and the second recess; filling the cavity with a resin; and removing a partial denture from the mold, the partial denture formed by the resin and the at least one artificial tooth.

MODULAR DENTAL DEVICES

Resumen de: US2025262031A1

Modular dental devices and methods of forming the same. The dental devices may include a first region having a first joining surface and a second region having a second joining surface. The first joining surface may have one or more protrusions and the second joining surface may include one or more corresponding features configured to mate with the one or more protrusions. The first and second regions may be coupled together at the first and second joining surfaces, where the one or more protrusions of the first joining surface mate with the corresponding features of the second joining surface to align the first region with the second region and to interlock the first and second regions.

SOCKET FORMING TOOLS FOR AUTOTRANSPLANTATION

Resumen de: US2025262033A1

A socket preparation tool configured to facilitate autotransplantation of a donor tooth to a recipient site is provided. The socket preparation tool includes a tooth replica of the donor tooth. A coronal portion is optionally included for facilitating alignment of the tooth replica adjacent teeth during a simulated autotransplantation. A radicular portion includes a smooth surface configured to facilitate compression of soft bone or soft tissue of the tooth replica or a contoured surface adapted for filing or cutting bone of the tooth replica. A cylindrical attachment is configured to be coupled to the tooth replica, such as via a receiver. A method of guided autotransplantation of a donor tooth via the customized socket preparation tool includes at least fitting and adjusting the socket preparation tool coupled to the tooth replica in the recipient site, before extracting the donor tooth.

INJECTION-MOLDED PARTIAL DENTURE APPLIANCES

Resumen de: US2025262036A1

A method according to the disclosure herein includes producing, via additive manufacturing, a first mold portion having a first recess based on a tooth portion of a patient mouth; producing, via additive manufacturing, a second mold portion having a second recess based on a gum portion of the patient mouth; positioning at least one artificial tooth in the first recess; aligning the first mold portion with the second mold portion to form a mold assembly having a cavity defined by the first recess and the second recess; filling the cavity with a resin; and removing a partial denture from the mold, the partial denture formed by the resin and the at least one artificial tooth.

CURABLE COMPOSITION FOR THREE-DIMENSIONAL STEREOLITHOGRAPHY, METHOD FOR PRODUCING SAME, METHOD FOR PRODUCING THREE-DIMENSIONAL STEREOLITHOGRAPHIC MODEL, AND METHOD FOR PRODUCING DENTAL RESTORATION

Resumen de: AU2024218051A1

The present invention provides a curable composition for three-dimensional stereolithography, the curable composition being used in a vat photopolymerization method and containing 100 parts by mass of a polymerizable monomer component (A), 40 parts by mass to 400 parts by mass of an inorganic filler (B) that is composed of a single kind or plural kinds of inorganic particulate matter, and 0.01 part by mass to 5 parts by mass of a photopolymerization initiator (C), wherein: 80% or more of all primary particles that constitute the inorganic filler (B) have a particle diameter of 0.05 µm to 5.0 µm; and a sample, which is formed of this curable composition for three-dimensional stereolithography and has a thickness of 0.5 mm, has a transmittance of 1.00% to 50.00% with respect to activation light. The present invention also provides a method for producing this curable composition for three-dimensional stereolithography. The present invention also provides a method for producing a three-dimensional stereolithographic model and a method for producing a dental restoration, each using this curable composition for three-dimensional stereolithography.

FULLY AUTOMATIC AI-BASED MANUFACTURING OF AN INSOLE

Resumen de: EP4602972A1

The present invention provides, inter alia, a method for designing an insole, comprising receiving a measurement of a foot sole associated with pressure, said measurement preferably being obtained by placing a load on a measurement surface; receiving a sole profile; determining, based on said measurement, one or more anatomical zones; determining, based on said anatomical zones, a foot profile comprising a major axis; determining, at least based on said foot profile and said anatomical zones, an interpolating surface; aligning the interpolating surface with the sole profile, to obtain an aligned 3D profile; generating, based on said aligned 3D profile, an instruction for manufacturing the insole; wherein said determining of the interpolating surface is realized according to a 3D characterization according to respective positions (y1, y2) on said major axis; wherein said determining of the interpolating surface comprises calculating, based on said foot profile and said anatomical zones, a plurality of at least two anchor coordinates (d0-d3) each lying in a respective cross-section corresponding to said respective positions (y1, y2), and calculating, based on said at least two anchor coordinates (d0-d3), an interpolating surface.

ORTHODONTIC DEVICE AND RELATED MANUFACTURING METHOD

Resumen de: EP4603053A1

A removable orthodontic device, suitable to obtain complex orthodontic movements and made with CAD-CAM techniques and 3D printing, comprising an orthodontic member, made from a shape memory polymer, in turn comprising: a restraint portion of a dental arch; a connection portion which is apt to be in contact with a palatal surface and/or a lingual surface; and one or more female members positioned at said connection portion; the orthodontic device further comprises one or more temporary anchorage devices (TADs), acting as orthodontic screw, comprising a shank, a hollow upper end and a protruding head which is attached to said upper end by a respecting connection screw, said head implementing a male connection member and being made from a shape memory polymer as well; said female members of said orthodontic member and said one or more TADs being shaped as to cooperate with each other implementing an automatic pressure connection, whereby a reversible connection mechanism is implemented.

付加製造用サポート材

Resumen de: US2025215166A1

This document describes a process of producing gel microparticles, which are consistent in size and morphology. Through the process of coacervation, large volumes of gel microparticle slurry can be produced by scaling up reactor vessel size. Particles can be repeatedly dehydrated and rehydrated in accordance to their environment, allowing for the storage of particles in a non-solvent such as ethanol. Gel slurries exhibit a Bingham plastic behavior in which the slurry behaves as a solid at shear stresses that are below a critical value. Upon reaching the critical shear stress, the slurry undergoes a rapid decrease in viscosity and behaves as a liquid. The rheological behavior of these slurries can be adjusted by changing the compaction processes such as centrifugation force to alter the yield-stress. The narrower distribution and reduced size of these particles allows for an increase in FRESH printing fidelity.

DENTAL APPLIANCE, SYSTEM, AND METHOD

Resumen de: CN120051256A

A dental appliance for a patient includes a body including a first surface and a second surface opposite the first surface. The second surface defines a channel for receiving a plurality of teeth of the patient. The dental appliance also includes an arrangement of a plurality of features disposed on the first surface of the body. Each feature of the plurality of features includes a protrusion extending from the first surface opposite the second surface; a recess extending partially from the first surface toward the second surface; or a via extending from the first surface to the second surface. The arrangement of the plurality of features encodes feature data representing dental appliance information of the dental appliance or patient information of the patient.

NERVE CONDUIT

Resumen de: AU2023361612A1

The invention relates to nerve conduits for connecting a lesioned nerve end to a target site. In particular, the invention relates to nerve conduits supporting repair of a nerve lesion and motor control and/or reducing risk of the development of a neuroma at the lesioned nerve end. Accordingly, a nerve conduit (10) for connecting a lesioned nerve end (26) to a target site (28) is suggested, comprising an elongate body (12) formed by a wall (22) and comprising a central portion (14) defining an inner cavity (16) and end portions (18, 19) defining a respective opening (20, 20') to the inner cavity (16) and arranged adjacent to the central portion (14) and at longitudinally opposing ends of the elongate body (12). One end portion (18) is configured as an insertion portion configured for inserting a respective nerve end (26). According to the invention, the other end portion is configured as a nerve end outlet portion (19), wherein an outer diameter of the wall defining the outlet portion (19) is larger than an outer diameter of the wall defining the central portion (14).

一种聚醚醚酮复合材料及其制备方法和在3D打印人工颅骨修复体中的应用

Resumen de: CN120501945A

本发明涉及一种聚醚醚酮复合材料及其制备方法和在3D打印人工颅骨修复体中的应用，涉及聚醚醚酮材料技术领域，以重量份数计，所述聚醚醚酮复合材料包括以下原料：聚醚醚酮50~60份、改性羟基磷灰石40~50份和壳聚糖4~9份。在现有聚醚醚酮/羟基磷灰石体系基础上，本发明通过采用含羧基的笼型聚倍半硅氧烷对羟基磷灰石改性并引入适宜脱乙酰度的壳聚糖，有效解决了因羟基磷灰石添加量过高导致的拉伸强度下降问题，同时改善了材料的柔韧性，获得了一种兼具高羟基磷灰石含量、优异拉伸强度和良好柔韧性的聚醚醚酮复合材料，可充分满足人工颅骨修复体等骨植入体的应用需求。

雾化器

Resumen de: WO2024133585A1

The present invention provides a nebuliser (100) comprising one or more inputs (110), and a plurality of droplet ejectors (126) in fluid communication with the one or more inputs (110). Each droplet ejector comprises a nozzle portion and a piezoelectric actuator. The one or more inputs are for receiving one or more liquids. Each nozzle portion defines a nozzle outlet in fluid communication with the one or more inputs. Each piezoelectric actuator is operable to cause ejection of a liquid received by one of the one or more inputs through the respective nozzle outlet as one or more droplets to thereby generate an aerosol comprising the one or more droplets ejected by each droplet ejector.

神经导管

Resumen de: AU2023361612A1

The invention relates to nerve conduits for connecting a lesioned nerve end to a target site. In particular, the invention relates to nerve conduits supporting repair of a nerve lesion and motor control and/or reducing risk of the development of a neuroma at the lesioned nerve end. Accordingly, a nerve conduit (10) for connecting a lesioned nerve end (26) to a target site (28) is suggested, comprising an elongate body (12) formed by a wall (22) and comprising a central portion (14) defining an inner cavity (16) and end portions (18, 19) defining a respective opening (20, 20') to the inner cavity (16) and arranged adjacent to the central portion (14) and at longitudinally opposing ends of the elongate body (12). One end portion (18) is configured as an insertion portion configured for inserting a respective nerve end (26). According to the invention, the other end portion is configured as a nerve end outlet portion (19), wherein an outer diameter of the wall defining the outlet portion (19) is larger than an outer diameter of the wall defining the central portion (14).

一种角蛋白基复合骨软骨的制备方法

Resumen de: CN120501931A

本发明涉及组织工程生物材料领域，尤其涉及一种角蛋白基复合骨软骨的制备方法和应用，制备方法将软骨层1、钙化软骨层2和软骨下骨层3组合为复合骨软骨。软骨层1为通过静电纺丝法和发泡技术制备的角蛋白基纳米纤维气凝胶，钙化软骨层2为采用静电纺丝法制备的富含钙磷离子的角蛋白纳米纤维膜，软骨下骨层3为利用3D打印技术制备的改性角蛋白基水凝胶材料。三层结构按顺序组合形成角蛋白基复合骨软骨。所制备的角蛋白基支架具有良好的生物相容性，有利于骨细胞的粘附增殖，具有促进骨软骨修复再生的功能。

一种双向强化高稳定浆料3D打印羟基磷灰石支架的制备方法

Resumen de: CN120501928A

本发明涉及一种双向强化高稳定浆料3D打印羟基磷灰石支架的制备方法，首先根据Furnas理论计算纳米球HA和微米球HA的最佳级配比例并进行级配，其次将光固化树脂单体和稀释剂单体按照不同比例混合，加入第一分散剂和光引发剂，避光搅拌，之后将粉体与树脂进行球磨并加入第二分散剂，混合均匀得到羟基磷灰石浆料，最后将羟基磷灰石浆料使用3D打印机打印支架，对打印支架进行清洗、脱脂烧结，得到双向强化高稳定浆料3D打印羟基磷灰石支架；本发明所制备的多孔支架孔隙率为62％，抗压强度可达到14.2MPa，同时通过双重分散剂结合球形粉体协同增强浆料稳定性，能有效提高浆料的流动性和固含量，提高打印支架质量和稳定一致性。

一种水凝胶组合试剂、一种强韧水凝胶

Resumen de: CN120504796A

本发明属于生物医学工程及医用材料领域，公开了一种水凝胶组合试剂，基于水凝胶组合试剂可制备一种强韧水凝胶，所述强韧水凝胶基于全新的双网络水凝胶，其网络由PEGMA/GelNB的共价交联网络和PEGMA自交联网络组成，降冰片烯作为一种刚性结构，在凝胶网络中可以起到一种类似弹簧的作用，可以显著提升水凝胶的拉伸和压缩性能，水凝胶组合试剂制备的强韧水凝胶具有良好的生物活性和优异的力学性能，可在温和条件下快速凝胶化。

一种自发电的椎间融合器及其制备方法

Resumen de: CN120501924A

本发明涉及一种自发电的椎间融合器及其制备方法，椎间融合器包括多孔钽支架和设置在多孔钽支架上的生物活性压电陶瓷，所述生物活性压电陶瓷包含羟基磷灰石和钛酸钡；制备方法包括以下步骤：通过3D打印制得多孔钽支架，并在多孔钽支架的上下表面预留生物活性压电陶瓷的组装位，将生物活性压电陶瓷嵌入多孔钽支架上下表面的组装位，钛酸钡和羟基磷灰石的重量比为(92～98)：(2～8)。与现有技术相比，本发明具有利用人体内机械力自发电促进椎体融合、融合器接触面力学性能匹配、提供骨生成相关离子、界面结合较好等优点。

一种磁力辅助制备成分梯度型熔体电写支架的方法

Resumen de: CN120501942A

本发明属于组织工程支架材料技术领域，具体涉及一种磁力辅助制备成分梯度型熔体电写支架的方法。本发明将含核壳结构磁性羟基磷灰石(Fe3O4纳米颗粒和包覆在其表面的羟基磷灰石壳层)、聚己内酯和二氯甲烷的分散液干燥，得到的mHA‑PCL复合原料加热至熔融状态形成的复合熔体经线性梯度磁场处理后，进行熔体电写打印，得到成分梯度型熔体电写支架。该方法通过核壳结构磁性羟基磷灰石在线性梯度磁场中的定向迁移，实现熔体电写支架中羟基磷灰石(HA)含量呈连续线性梯度分布，模拟骨软骨组织内部存在的自然的钙化梯度结构，提升支架的仿生性能，解决传统熔体电写方法制备的支架中HA浓度突变，无法实现梯度渐变的问题。

A METHOD FOR TREATING SPONTANEOUS INTRACEREBRAL HEMORRHAGE (ICH) USING 3D-PRINTED NAVIGATION GUIDE TECHNOLOGY COMBINED WITH NEUROENDOSCOPIC HEMATOMA EVACUATION

Nº publicación: LU600255B1 18/08/2025

Solicitante:

AIR FORCE MEDICAL UNIV [CN]
AIR FORCE MEDICAL UNIVERSITY

Resumen de: LU600255B1

This invention relates to a method for treating spontaneous intracerebral hemorrhage using a 3D-printed navigation guide plate combined with neuroendoscopic hematoma evacuation. The method aims to address the issue in existing technologies where relying on preoperative head CT scans for manual puncture marking on the body surface makes precise localization difficult. This innovation improves puncture accuracy, reduces surgical risks, and enhances patient prognosis. By utilizing the patient’s CT DICOM data along with 3D printing technology, the method creates a personalized navigation guide plate model. It precisely designs the puncture route and depth, ensuring accurate localization and puncture during the surgical process. Experimental results show that compared to traditional methods, this invention significantly improves hematoma evacuation rates, reduces intraoperative blood loss, shortens surgery duration, and lowers the incidence of postoperative complications.