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増強又は骨充填のための部分的な骨梁要素

Resumen de: AU2023303676A1

Element (100, 200, 300) for augment or bone filler, comprising at least one first outer-layer portion (101) having a trabecular lattice of metallic material, and further comprising at least one reinforcing inner layer (103) of metallic material having a plurality of channel structures (104) arrayed with respective channel openings (105) delimited by edges in structural contact with the at least one first outer-layer portion (101).

一种基于3D打印的双层载药植入体及其制备方法与应用

Resumen de: CN121570412A

本发明属于药物共递送技术领域，具体涉及一种基于3D打印的双层载药植入体及其制备方法与应用。本发明通过合成明胶甲基丙烯酸酯GelMA；制备2‑氨基葡萄糖修饰的奥沙利铂Oxa‑2‑DG；MExo的提取与纯化；GelMA的3D打印与AI优化最终制备获得具有双层结构的载药植入体LEH@OG。本发明制备的共递送平台可在腹腔内降解，实现内外层药物的序贯释放，具有较高的生物安全性，对各组织脏器均无明显损伤。并表现出强大的抗肿瘤疗效和免疫激活作用。

一种种植模型3D打印树脂材料及其应用

Resumen de: CN121570635A

本发明公开了一种种植模型3D打印树脂材料，包含如下按重量份计的原料组分：聚氨酯丙烯酸酯低聚物30‑50份；单官能团活性稀释剂30‑40份；双官能团活性稀释剂20‑40份；光引发剂1‑3份；流平剂0.1‑3份；消泡剂0.1‑3份；填料0.5‑3份；耐刮蜡0.5‑3份；颜料0.2‑0.5份；聚氨酯丙烯酸酯低聚物与活性稀释剂的质量比为（0‑1）：1；所述单官能团活性稀释剂和双官能团活性稀释剂的质量比为（1‑1.5）：1。该树脂材料通过引入聚氨酯丙烯酸酯体系，改善后的光敏树脂通过3D打印制造的种植牙模，具有高下机精度、高逆扫尺寸稳定性、高性价比，应用于口腔医学领域。

一种蜂窝状刚性-柔性两相颗粒及其在光固化3d打印树脂中的应用

Resumen de: CN121574311A

本发明公开了一种蜂窝状刚性‑柔性两相颗粒及其在光固化3d打印树脂中的应用。该蜂窝状刚性‑柔性两相颗粒包括柔性聚氨酯相和刚性氧化硅相。制备步骤S1、制备包含聚氨酯颗粒的乳液作为种子乳液（乳液A）；S2、制备包含氧化硅前体和引发剂的乳液（乳液B）；S3、将乳液B加入到乳液A中，混合均匀得到混合液；S4、在施加动态作用和无氧条件下，将混合液升温至60‑80℃反应20～24h，得到含有蜂窝状刚性‑柔性两相颗粒的乳液。将含有蜂窝状刚性‑柔性两相颗粒的乳液加入到具有光固化性能的可降解聚合物材料中能同时提升聚合物材料的韧性和强度，且不影响聚合物的光固化性能和生物相容性；适用于作为填料添加到高精度光固化3d打印制备的各类成型制品。

一种颈椎单开门手术3D打印导板的制作方法

Resumen de: CN121572598A

本发明公开了一种颈椎单开门手术3D打印导板的制作方法，涉涉及医疗辅助器械与增材制造交叉技术领域，先获颈椎CT数据三维重建骨骼模型，虚拟规划手术方案，再参数化生成导航模板数字化原型，经有限元仿真优化，用光固化设备以生物相容性树脂打印，最后处理得终产品。本发明通过CT薄层扫描与三维重建生成高精度颈椎骨骼模型，经虚拟规划确定铰链区、开门槽线及钉道参数，解决传统手术依赖经验易致损伤或定位偏差问题；再以特定算法构导航模板贴附曲面并留软组织补偿间隙，配镂空窗凸起限磨钻深度，同时经有限元仿真与拓扑优化控导板变形，选特定树脂保稳定性，借虚拟配准与标准化制造保适配性，提升手术精准安全与效率。

POROUS INTERBODIES

Resumen de: WO2026043576A1

In various aspects, an implant includes a body having a lattice structure, with the lattice structure extending continuously from a superior surface of the body to an inferior surface of the body. The lattice structure may define a gradient of pores, with each pore in the gradient having a plurality of vertices. Additionally, the implant may include a plurality of projections extending superiorly from each of the plurality of vertices of each pore of the gradient of pores at the superior surface of the body, with each projection of the plurality of projections having a directionality. The implant may also include one or more radiographic markers incorporated into the lattice structure, the one or more radiographic markers having a density greater than the density of the lattice structure immediately around the one or more radiographic markers and being comprised of the same material as the lattice structure.

CURABLE COMPOSITION FOR THREE-DIMENSIONAL STEREOLITHOGRAPHY, METHOD FOR PRODUCING OBJECT BY THREE-DIMENSIONAL STEREOLITHOGRAPHY, AND METHOD FOR PRODUCING DENTAL RESTORATION

Resumen de: WO2026042469A1

Provided is a curable composition for three-dimensional stereolithography, the curable composition containing 100 parts by mass of a radical polymerizable monomer (A), 5.0-400 parts by mass of an inorganic filler (B), 0.05-10.0 parts by mass of a photopolymerization initiator (C) containing an acylphosphine compound, 0.01-5.0 parts by mass of a polymerization inhibitor (D), and 0.01-10.0 parts by mass of a photosensitizer (E) including a thioxanthone compound represented by formula (1). The present invention also provides a method for producing an object by three-dimensional stereolithography and a method for producing a dental restoration, the methods using said curable composition for three-dimensional stereolithography. In the formula, Y1 to Y8 each independently represent a hydrogen atom, an alkyl group having 1-20 carbon atoms, or the like.

METHOD OF TREATING A WOUND AND METHOD OF MANUFACTURING A SKIN GRAFT

Resumen de: WO2026043980A1

Synthetic skin constructs are produced using 3D bioprinting and a cleaning process involving supercritical carbon dioxide (ScCO2). The ScCO2 process effectively removes all cellular materials, minimizing the risk of immune rejection and ensuring the skin constructs are safe and optimally effective.

3D BIOPRINTED LIVER

Resumen de: WO2026043615A1

The present disclosure provides 3D bio-printed livers and methods of making or using the same. Aspects of the disclosure relate to compositons of 3D bio-printed livers. In some embodiments, the 3D bio-printed livers comprise a mesh casing, a plurlaity of microporous organoid-infused microgel matrices, and a hetaptic vasculature. Other aspects of the disclosure relate to methods of making the 3D bio-printed livers dislcosed herein. In some embodiments, the methods relate to creating a mesh casing in the shape of a liver, or portion thereof, loading a plurality of microporous organoid-infused microgel matrices into the mesh casing, and using embedded bioprinting to create a hepatic artery, a portal vein, and biliary duct within the mesh casing.

三次元成形の粘土製猫砂

Resumen de: CN120752087A

The present invention is a process for preparing shaped three-dimensional clay particles with improved absorbency suitable for use in cat litter. The method is three-dimensionally printing a clay slurry into a desired particulate shape, where the printed clay particles (when printed at low temperature and when dried) provide improved absorbency compared to extruded clay particles. The particles are not pulverized and are not sintered at high temperatures.

SYSTEM, METHOD AND APPARATUS FOR PERSONALIZED DENTAL PROSTHESES PLANNING

Resumen de: US20260053603A1

Methods, systems, and techniques for collecting data for use in designing a personalized dental prosthesis for a patient. At least one camera is used to obtain a series of two-dimensional photos or a three-dimensional model of a head and face of the patient. At least one machine learning model is used to determine facial or oral landmarks and a central incisal edge of the prosthesis from the photos or model. Dimensions for the dental prosthesis are determined form the landmarks and central incisal edge. The dimensions include a labial border of the prosthesis, distal borders of the prosthesis, a superior border of the prosthesis, an inferior border of the prosthesis, a lingual border of the prosthesis, and buccal borders of the prosthesis. The dimensions are output to an output file for use in manufacturing the prosthesis.

ENZYME AND NANOZYME LOADED MICROPARTICLES

Resumen de: AU2023463148A1

This invention describes microcapsule compositions and methods to encapsulate gas modulating enzymes or nanozymes at unprecedented concentrations and stability, that can be used to regulate the local gas concentrations. Microcapsules can be comprised of gelatin with a polydopamine coating. This system can replace expensive incubators/chambers and is the first system that can create spatiotemporal gradients of gases within a finite volume. The microcapsules have a broad range of applications in tissue culture, bioprinting, in vivo, and industrial uses.

RECOMBINANT PROTEINS, RECOMBINANT DNA SEQUENCES, VECTORS, EUKARYOTIC AND PROKARYOTIC EXPRESSION SYSTEMS AND THEIR USE

Resumen de: AU2024288436A1

The invention relates to recombinant RE15mR and EJ17zipR hybrid proteins with the structure specified in the description, recombinant DNA sequences encoding recombinant hybrid proteins, vectors containing recombinant DNA sequences, as well as eukaryotic or prokaryotic expression systems transformed with recombinant DNA sequences. The invention also concerns the use of recombinant hybrid proteins as components of bioink intended for bioprinting, and also as components of biomaterials. Furthermore, the invention relates to the use of recombinant DNA sequences, vectors and eukaryotic or prokaryotic expression systems for the production of recombinant hybrid proteins.

ADDITIVE MANUFACTURING PART SUPPORT AND HANDLING FRAME

Resumen de: AU2025210859A1

A cutting instrument includes an insert and a frame having sidewalls that extend from a base and define a slot. The slot is configured to receive a portion of the insert such that an edge of the insert extends beyond the frame. The sidewalls are configured to shrink around a portion of the insert such that an edge of the insert extends beyond the frame. Additionally, a method for fabricating a cutting instrument includes depositing layers of metal powder onto a base and selectively binding the deposited layers of the metal powder onto the base to form a frame attached to the base. Next, placing an insert within the frame such that a portion of the insert extends beyond the frame and the combination of the base, the frame, and the insert forms an in-process assembly. A cutting instrument includes an insert and a frame having sidewalls that extend from a base and define a slot. The slot is configured to receive a portion of the insert such that an edge of the insert extends beyond the frame. The sidewalls are configured to shrink around a portion of the insert such that an edge of the insert extends beyond the frame. Additionally, a method for fabricating a cutting instrument includes depositing layers of metal powder onto a base and selectively binding the deposited layers of the metal powder onto the base to form a frame attached to the base. Next, placing an insert within the frame such that a portion of the insert extends beyond the frame and the combination of the base, th

ADDITIVE MANUFACTURING OF EMBEDDED MATERIALS

Resumen de: US20260053988A1

In one aspect, a method includes providing support material within which the structure is fabricated, depositing, into the support material, structure material to form the fabricated structure, and removing the support material to release the fabricated structure from the support material. The provided support material is stationary at an applied stress level below a threshold stress level and flows at an applied stress level at or above the threshold stress level during fabrication of the structure. The provided support material is configured to mechanically support at least a portion of the structure and to prevent deformation of the structure during the fabrication of the structure. The deposited structure material is suspended in the support material at a location where the structure material is deposited. The structure material comprises a fluid that transitions to a solid or semi-solid state after deposition of the structure material.

METHOD OF ASSEMBLING A BIOREACTOR HAVING A BIOLOGICAL MATERIAL DEPOSITING END THAT IS MOVABLE WITH THE TOP PORTION TO ALLOW BIOPRINTING

Resumen de: US20260055354A1

A bioreactor allowing bioprinting inside an interior volume thereof is assembled to form a side wall extending upwardly from a base provided with a target support for the bioprinting. Once an adapter has been coupled to a bioreactor top portion to plug a corresponding aperture O4, a biological material depositing end may be maintained in an inserted state, extending through and/or being adapted to be fed via the aperture. A sealed enclosure, including the side wall and ports, is formed by a sealing operation to interconnect the base and the top portion. Bioprinting is done by driving from outside the depositing end, using variation of said volume, for delivering the biological material on the support and then, a culture and/or maturation phase of the printed tissue may start inside the enclosure, without displacement of the printed tissue.

SOCKET FORMING TOOLS FOR AUTOTRANSPLANTATION

Resumen de: US20260053600A1

A socket preparation tool configured to facilitate autotransplantation of a donor tooth to a recipient site is provided. The socket preparation tool includes a tooth replica of the donor tooth. A coronal portion is optionally included for facilitating alignment of the tooth replica adjacent teeth during a simulated autotransplantation. A radicular portion includes a smooth surface configured to facilitate compression of soft bone or soft tissue of the tooth replica or a contoured surface adapted for filing or cutting bone of the tooth replica. A cylindrical attachment is configured to be coupled to the tooth replica, such as via a receiver. A method of guided autotransplantation of a donor tooth via the customized socket preparation tool includes at least fitting and adjusting the socket preparation tool coupled to the tooth replica in the recipient site, before extracting the donor tooth.

POROUS INTERBODIES

Resumen de: US20260053633A1

In various aspects, an implant includes a body having a lattice structure, with the lattice structure extending continuously from a superior surface of the body to an inferior surface of the body. The lattice structure may define a gradient of pores, with each pore in the gradient having a plurality of vertices. Additionally, the implant may include a plurality of projections extending superiorly from each of the plurality of vertices of each pore of the gradient of pores at the superior surface of the body, with each projection of the plurality of projections having a directionality. The implant may also include one or more radiographic markers incorporated into the lattice structure, the one or more radiographic markers having a density greater than the density of the lattice structure immediately around the one or more radiographic markers and being comprised of the same material as the lattice structure.

MANUFACTURE OF PATIENT-SPECIFIC ORTHODONTIC BRACKETS WITH TOOTH-SPECIFIC BREAKAWAY MECHANISM

Resumen de: US20260053596A1

Embodiments may provide improved techniques for creating custom lingual or labial ceramic orthodontic brackets, and which provides the capability for in-office fabrication of such brackets. For example, a method of manufacturing customized ceramic labial/lingual orthodontic brackets by ceramic slurry-based AM may comprise measuring dentition data of a profile of teeth of a patient, based on the dentition data, creating a three dimensional computer-assisted design (3D CAD) model of the patient's teeth using reverse engineering, and saving the 3D CAD model on a computer, designing a 3D CAD bracket structure model for a single labial or lingual bracket structure, importing data related to the 3D CAD bracket structure model into a ceramic slurry-based AM machine, directly producing the bracket (green part) in the ceramic slurry-based AM machine by layer manufacturing, and processing the brackets in a sintering and debinding oven prior to direct use.

MICRONEEDLE PARTICLES FOR ENHANCED TOPICAL TRANSDERMAL DRUG DELIVERY

Resumen de: US20260053731A1

A microneedle particle arranged to be rolled and massaged on a subject's skin to penetrate the stratum corneum is disclosed. The microparticle comprises a support body, and a plurality of microneedles protruding from the support body (20), each microneedle comprising a tip. The support body maintains the microneedles and tips in a predetermined conformation allowing the microneedle particle to be rolled on the skin. The microneedles have an average tip sharpness radius of less than 20 μm, an average microneedle length of less than 100 μm, and an average tip sharpness to microneedle length ratio of 1:5 to 1:200. Formulations and kits for said use are provided. A microneedle particle manufacturing method using a non-linear two-photon absorption process, a non-therapeutic cosmetic method of skin treatment, and a method of drug delivery through the skin for said microneedle particle are disclosed.

DENTAL DEVICE WITH INTEGRATED FLUIDIC RESERVOIR AND MICROCHANNELS, AND METHOD FOR MANUFACTURING SAID DENTAL DEVICE

Resumen de: WO2026041252A1

The present invention is related to a dental device (1) intended to cover at least part of a teeth (2) and/or at least part of gums (3) or other surfaces of a mouth for repositioning or retaining said teeth (2) and optionally said gums (3) or other surfaces of the mouth, said dental device (1) comprising a channel (7) provided in a main body (31; 40, 42) of the dental device (1) and having at least one opening (4, 5) to the exterior. The present invention is also related to a method of manufacturing said dental device (1) by additive manufacturing and to methods for circulating a substance and/or saliva and oxygen through the dental device (1) in view of releasing said substance and/or saliva and oxygen inside the mouth.

ROTATIONAL STEREOLITHOGRAPHY FOR ARCUATE 3D ARTICLES

Resumen de: CN120981335A

A three-dimensional (3D) printing system is configured to manufacture a plurality of arcuate 3D articles. The 3D printing system includes a build container, at least one build component, a light engine, and a controller. The at least one build assembly includes a shaft, a build plate, and a motorized gear assembly, respectively. A motorized gear assembly is coupled to the shaft and configured to rotationally position the shaft about an axis of rotation. The light engine is located above the build container. The controller is configured to operate the motorized gear assembly to progressively rotate the build plate between a plurality of stop positions about the axis of rotation. The controller is configured to operate the light engine at respective stop positions to selectively illuminate the photocurable liquid in a plurality of spatially separated build planes respectively above one of the plurality of build plates.

CALIBRATING A DISPENSING MEANS OF A 3D BIO-PRINTER

Resumen de: CN120957859A

The present disclosure relates to a method, a system, a 3D bio-printer including a control system, a computer program carrier, and a computer program product. A computer-implemented method comprises acquiring sensor data representative of a printhead (1) of a 3D bioprinter and the surroundings of the printhead, the acquired sensor data comprising one or more images of the printhead of the 3D bioprinter captured by means of an imaging sensor device (6). Further, the method includes providing the acquired sensor data to a trained neural network algorithm. The method further includes generating one or more predicted outputs representative of calibration conditions of the distribution device by means of a neural network algorithm.

ホスフィンオキシド系光開始剤

Resumen de: CN120435392A

The present invention relates to phosphine oxide-based photoinitiators, to a method for producing said photoinitiators and to precursors which can be used for producing said photoinitiators. The invention also relates to a photoinitiator composition, a curable composition, a method of preparing a cured product, an inkjet printing method, a 3D printing method and a method of coating nails. The invention also relates to a photoinitiator composition or a precursor of a photoinitiator. The invention also relates to the use of a photoinitiator or a photoinitiator composition.

DEVICE AND METHOD FOR FOOTWEAR CUSTOMIZATION

Nº publicación: EP4698003A1 25/02/2026

Solicitante:

SUPERFEET AGGREGATOR LLC [US]
Superfeet Aggregator LLC

Resumen de: US20260020643A1

A device and method for the formation of customized footwear insoles and pads is provided. The system employs computers operatively engaged to scanning components to produce individual electronic footprints of a foot of a wearer. Software operating to the tasks of employing the digital data from one or a plurality of electronic footprints, correlating to scans of the feet of a footwear user, will customize an insole or pad for positioning in the footwear to more comfortably support the foot therein.