Alerta

METAL OXIDE BIOLOGICAL IONOMER AND METHODS

Resumen de: US20260102509A1

A nanoparticle compound comprising buckminsterfullerene C60 bonded to ester functional groups of pyruvic, citric, and hyaluronic acids, with oxygen-bridged components selected from vanadium, gallium, and bismuth is provided. At least one component enables quantum-mechanical spin-wave activation. Ultrasonic irradiation activates the compound, inducing electrical induction for tissue healing and cell growth. The compound integrates with native and 3D-printed tissues, enhancing their properties through interpenetrating networks. It exhibits anti-inflammatory, antioxidant, and antibacterial effects, reinforces connective tissue, and modulates stem cell growth. The compound treats arthritis, enhances gut health and barrier function, supports bone health, improves voice quality, counters cancer cell proliferation, and mitigates osteoporosis. The gallium component creates an alkaline environment for calcium deposition, while vanadium enhances chondrogenic differentiation. Administration methods include topical application, oral ingestion, injection, and infusion through bandages or sutures. The compound serves as an adjuvant for analgesics, enhancing their delivery and efficacy.

SYSTEMS AND METHODS FOR BIOPRINTING CORNEAL STROMA EQUIVALENTS

Resumen de: WO2026078545A1

Synthetic corneal stroma are created though a bioprinting process. The bioprinting process utilizes Digital Light Processing (DLP) in the formation of the corneal stroma. A hydrogel is formed to serve as the basis for the DLP printing. The DLP printing process provides control exposure of the hydrogel to UV light. The bioprinting through the DLP printing process forms a synthetic corneal stroma.

3D SCANNING METHOD, SYSTEM AND APPARATUS FOR DENTAL APPLICATIONS

Resumen de: US20260102230A1

A method and device for aligning face scans with intraoral scans in dentistry applications. Digital intraoral scans capture the upper and lower arches and a bite registration. An Anterior Extension Device is affixed in the patient's mouth. A working scan of the upper arch scan is trimmed to remove the areas covered by the Anterior Extension Device. A rigid reference link extends between the Anterior Extension Device and base of the patient's nose. The working scan is rescanned to include the Anterior Extension Device and rigid reference link and patient's nose. A facial scan is taken while the patient is smiling. The rescanned working scan is aligned and merged with the facial scan on the basis of at least three points of reference on the patient's nose. A prosthetic device is designed using in combination the intraoral scans aligned with the facial scan.

APPARATUS AND METHOD OF DETERMINING A CARDIAC IMPLANT SIZE AND METHODS AND SYSTEMS FOR TRANSESOPHAGEAL ECHOCARDIOGRAM GUIDED IMPLANTATION OF LEFT ATRIAL APPENDAGE CLOSURE DEVICE

Resumen de: WO2026080652A2

Apparatus and methods of determining a cardiac implant size and methods and system for transesophageal echocardiogram guided implantation of left atrial appendage closure device. The apparatus includes an ultrasonic imaging device, at least a processor, and a memory communicatively connected to the at least a processor, wherein the memory contains instructions configuring the at least a processor to using the ultrasonic imaging device collect a plurality of ultrasonic images using a 3D cardiac model generation machine learning model trained on a training dataset including example ultrasonic images correlated with example 3D cardiac models. The processor is further configured to generate a 3D cardiac model based on the plurality of ultrasonic images, generate at least a cardiac measurement based on the 3D cardiac model, determine a cardiac implant size based on the at least a cardiac measurement, and using a display, display to a user the cardiac implant size.

MULTI-FUNCTIONAL POLYMERIZABLE COMPOUNDS AND METHODS OF PRODUCING AND USING THE SAME

Resumen de: WO2026080633A1

The present disclosure provides synthesizing multi-functional polymerizable compounds and methods for the synthesizing the same. The methods include reacting a compound of Formula (Ia) with an epoxide of Formula (Ib) with quantitative conversion, requiring only an aqueous work-up for purification. Further provided herein are methods of producing polymerizable composition, methods of forming an article by additive manufacturing processes (e.g., via 3D printing), such as orthodontic appliances with increased stain resistance.

3D STRUCTURE-FUNCTIONAL DESIGN OF BIOMASS-DERIVED SOLAR PHOTOCATALYST FOR ANTIMICROBIAL EFFICACY AND CHEMICAL DEGRADATION AT AMBIENT CONDITIONS

Resumen de: US20260102758A1

The subject invention pertains a stable, three-dimensional (3D) photocatalyst composition comprising TiO2 doped with carbon derived from lignin. The photocatalyst composition has a stable, hollow, spherical or spheroid nanoparticle structure, which improves photodegradation under visible light irradiation over unmodified TiO2 photocatalysts. The subject invention also provides methods of preparing the photocatalyst, as well as methods using the photocatalyst to remediate contaminants such as pharmaceuticals, pathogens and persistent organic pollutants.

3D PRINTABLE ANTHROPOMORPHIC PHANTOM FOR MIMICKING THE DIELECTRIC PROPERTIES OF MAMMARY TISSUES AND USE THEREOF

Resumen de: WO2026078280A1

The present invention relates to a breast phantom, comprising: a first hydrogel that forms a simulated phantom of normal breast tissue and a second hydrogel that forms a simulated phantom of cancerous breast tissue, wherein the first hydrogel comprises cross-linked 2-hydroxyethyl acrylate and the second hydrogel comprises cross-linked methacrylate hyaluronic acid. The present invention also relates to the method of preparing said phantom and to its use.

SYSTEM AND METHODS FOR LOCATING DRIVERS OF ATRIAL FIBRILLATION

Resumen de: US20260102102A1

The present disclosure applies to methods of cardiac ablation that use an algorithm to determine where in the heart a driver of atrial fibrillation is located. Catheters with multi-electrode arrays are used to measure electrograms from cardiac signals wherein abnormal signals are identified as electrogram deflections with characteristic shapes. The electrogram deflections are compared to each other in pairs to determine which came first in time in order to determine the net direction of propagation of a fibrillatory wave. The signal that came first is assigned a positive point value so that once the plurality of electrograms have been compared, the signal with the highest point value can be identified as a driver of fibrillation. The data can be displayed graphically as a map of atrial fibrillation drivers on a 3D representation of a heart, allowing surgeons to quickly and easily identify where on the heart the driver is.

PATHOGEN MONITORING SYSTEM AND METHOD

Resumen de: WO2026080101A2

The portable sensor system (100) includes a containment portion (102) and a sensor portion (104). The containment portion (102) may include a shipping container such as a jar. The sensor portion (104) may include a cap (106) that may be selectively coupled with the containment portion (102). The cap (106) may include a battery module (108), a processing module (110), and a sensor module (112). In a specific example, the portable sensor system (100) may be provided in four layers (a battery module layer (108), a processing module layer (110), a sensor module layer (112), and a coupling mechanism layer (114). The coupling mechanism layer (114) may be configured to selectively lock the cap (106) to the containment portion (102). In a more specific example, one or more of the layers (108, 110, 112, 114) may be 3D printed. The portable sensor system (100) may be utilized as a smart-monitoring device for the presence of a pathogenic bacteria in the shipping container.

INJECTION MONITORING MODULE

Resumen de: WO2026078408A1

An injection monitoring module comprises an indicator of rotational movement about a lengthwise axis; a sensor configured to contactlessly detect rotational movement of the indicator about the lengthwise axis; a processor connected to the sensor, wherein the processor is configured to receive and process signals from the sensor; wherein, in a first axial position of the injection monitoring module, the indicator of rotational movement is prevented from rotational movement about the lengthwise axis; and wherein, in a second axial position of the injection monitoring module, distinct from the first axial position, the indicator is free to corotate about the lengthwise axis along with a dose dispensing component of an injection pen system, onto which, or into which, the injection monitoring module has been mounted.

SYSTEMS, METHODS, AND DEVICES FOR TARGET CONTROLLED INFUSION

Resumen de: US20260102564A1

0000 A system for programming infusion devices for target controlled infusion is disclosed. The system includes a docking station and one or more processors configured to determine a first infusion device docked with a docking station and accept user input of one or more of patient-specific parameters, drug-related parameters, and a desired target concentration of a therapeutic agent in a workflow on the first infusion device for programming a target controlled infusion (TCI) therapy. After receiving a particular set of parameters, the set of parameters can be copied to the second infusion device to pre-complete and bypass a number of workflow steps of a second workflow of another infusion device. When the second workflow is accessed, the number of workflow steps of the second graphical interface workflow are pre-completed and bypassed.

DEEP REINFORCEMENT LEARNING BASED ROBUST NEUROVASCULAR MAPPING

Resumen de: US20260105597A1

Systems and methods for generating a patient-specific vascular tree are provided. 1) one or more medical images of a patient and 2) a vascular tree template comprising a plurality of points are received. The plurality of points of the vascular tree template are iteratively adjusted based on the one or more medical images using one or more AI (artificial intelligence) agents to generate a patient-specific vascular tree for the patient. The patient-specific vascular tree is output.

Systems and Methods for Determining the Orientation of Motion-Sensing Devices During Physical Activity

Resumen de: US20260102656A1

0000 A computer-implemented method for providing real-time performance feedback includes receiving uncalibrated time-series motion data generated by one or more motion sensors coupled directly or indirectly to an athlete while performing a downhill snow sport, the motion sensor(s) having an unknown rotational orientation relative to the athlete; determining an estimated rotational offset of the motion sensor(s) relative to a body-segment coordinate frame of the athlete, the rotational offset determined using a calibration model; transforming, by the one or more processors, the uncalibrated time-series motion data to calibrated time-series motion data according to the estimated rotational offset, the calibrated time-series motion data aligned with the body-segment coordinate frame; and processing the calibrated time-series data, with the one or more processors, to determine one or more metrics for the athlete.

SMART RING DEVICE FOR IDENTIFYING POSTURE OF USER

Resumen de: WO2026079901A1

According to an embodiment, a smart ring device may comprise a housing comprising a first surface for contacting a portion of a user's body and a second surface opposite to the first surface. The housing may comprise a conductive portion disposed to surround the portion of the user's body along the second surface. The smart ring device may comprise: a radio frequency (RF) coupler connected to the conductive portion; a memory including instructions and including one or more storage media; and at least one processor including a processing circuit. The instructions, when executed individually or collectively by the at least one processor, may cause the smart ring device to obtain impedance information about the conductive portion on the basis of a feedback signal obtained through the RF coupler while a signal is transmitted or received through the conductive portion. The impedance information may be used as input data for an artificial intelligence model configured to identify the posture of the portion of the body.

MEDICAL DEVICE

Resumen de: WO2026079016A1

A medical device 1 is used with a consumable 2 attached thereto. The consumable 2 has a usage time limit stipulated, and the consumable 2 has an information presentation unit 21 for presenting individual identification information of the consumable 2. The medical device 1 includes a reading unit 3 for reading the individual identification information from the information presentation unit 21, and a consumable management unit 41 that, on the basis of the individual identification information presented by the information presentation unit 21, monitors usage time of the consumable 2 and determines whether the usage time of the consumable 2 has reached the usage time limit.

SYSTEM AND METHOD FOR MANUFACTURING AN X-RAY BONE PHANTOM

Resumen de: US20260102135A1

A computer-implemented method for manufacturing an X-ray bone phantom is provided. The computer-implemented method includes obtaining, via a processing system comprising one or more processors, dual-energy scan data from one or more dual-energy scans of an ex vivo bone phantom. The computer-implemented method also includes converting, via the processing system, the dual-energy scan data into a two-dimensional image. The computer-implemented method further includes printing, via the processing system, a semi-anthropomorphic X-ray bone phantom made of aluminum based at least on the two-dimensional image, wherein the semi-anthropomorphic X-ray bone phantom is configured to provide quantitative areal bone mineral density and a realistic projected bone morphology for image quality assessment and lateral distance measurements during calibration.

PROCESS OF DESIGNING AND MANUFACTURING AN ORTHOTIC OR PROSTHETIC DEVICE

Resumen de: WO2026077490A1

The object of the invention is a process of designing and manufacturing an orthotic or prosthetic device comprising a step of preparing a region of a surface (2) of a user's body intended for application of the device for scanning, a step of scanning the region of the surface (2) of the user's body for creating an initial digital model (3), a step of processing the initial digital model (3) to a modified digital model (4) and a step of manufacturing the orthotic or prosthetic device (1) based on the modified digital model (4). The step of preparing the region of the surface (2) of the user's body comprises fastening at least one shape element (5) to a part of the region of the surface (2) of the user's body intended for application of the device (1) for modification of the shape of the outer surface of the user's body in this part.

Mandibular Advancement Device (MAD) having adjustment features

Resumen de: US20260102276A1

0000 A dental article of manufacture comprising a first appliance, and a second appliance. The first appliance fits dentition of a patient’s lower dental arch, and the second appliance fits dentition of the patient’s upper dental arch. The first appliance has a first feature positioned at its midline and located at a given distal offset with respect to an incisal edge when fitted on the lower dental arch. Preferably, the second appliance has a second cooperating feature positioned at its midline and includes a closed cavity having a front-facing opening. The second feature is designed to mate with the first feature. To this end, the second feature is positioned to removably receive the first feature only through the facing opening. In use, the second feature retains the first feature in the closed cavity against backwards and up or down movement when the second appliance is fitted on the upper dental arch.

SYSTEM AND METHOD FOR GENERATING AN APPLIANCE

Resumen de: US20260105213A1

In some embodiments systems and methods are provided for an automated system for generating an appliance for a body part that utilizes artificial intelligence and machine learning to identify points in a scan, generate a surface from the identified points, and generate the appliance for the body part.

DESIGNING PATIENT-SPECIFIC SURGICAL ITEMS

Resumen de: WO2026078555A1

A method of designing a patient-specific surgical item comprising: obtaining, by one or more processors, a 3-dimensional (3D) item model representing at least a surface of a patient-specific surgical item that is shaped to conform to one or more anatomical structures of a patient; determining, by the one or more processors, a size of a 3D primitive shape and a position of the 3D primitive shape such that the 3D primitive shape is collocated with a protrusion artifact of the 3D item model; modifying, by the one or more processors, the 3D item model to exclude portions of the 3D item model collocated with the 3D primitive shape; and generating, by the one or more processors, output data based on the modified 3D item model.

COMPOSITIONS AND METHODS FOR ADDITIVE MANUFACTURING OF PALATAL EXPANDERS

Resumen de: US20260102224A1

0000 Materials, methods, and systems for additive manufacturing are provided. In some embodiments, a method includes: forming a mixture including a first thermoplastic polymer powder separated from a first additively manufactured dental appliance manufactured during a first powder bed fusion process, where the first thermoplastic polymer powder has a characteristic particle size distribution and a characteristic melt volume rate; in a second powder bed fusion process, depositing a powder layer of the mixture, where the powder layer has a powder packing consistency dependent on the characteristic particle size distribution of the first thermoplastic polymer powder; and in the second powder bed fusion process, applying energy to the powder layer to melt the powder layer to form a part layer of a second additively manufactured dental appliance, where the part layer has a material consistency dependent on the characteristic melt volume rate of the first thermoplastic polymer powder.

PRINTER FOR COSMETICS

Resumen de: WO2026079532A1

The present invention relates to a printer for cosmetics that can easily form clear design patterns on the surfaces of cosmetic materials, the printer for cosmetics comprising: a support part for supporting at least one cosmetic material; a header part that includes an ejection port for ejecting an ink composition onto the surface of the cosmetic material and is configured to reciprocate along a first direction; and a first heating part and a second heating part which have the header positioned therebetween and are arranged along a second direction that forms a predetermined angle with respect to the first direction.

SYSTEMS AND METHODS FOR SYSTEM AGNOSTIC AUTOMATED DETECTION OF CARDIOVASCULAR ANOMALIES AND/OR OTHER FEATURES

Resumen de: US20260105608A1

0000 Systems and methods are provided for processing image data generated by a medical imaging system such as an ultrasound or echocardiogram system using artificial intelligence and machine learning to determine a presence of one or more congenital heart defects (CHDs) and/or other cardiovascular anomalies in the image data in a manner that is agnostic to the type of imaging system, software, and/or hardware. Image data from various types imaging systems, software, and/or hardware, having various styles of imaging data generated may be processed to determine image styles. Input image data for analysis may then be processed together with representative styles of image data to generate styled input images for each style. The styled input images may be processed by an image analyzer to detect one or more cardiovascular anomalies in the styled image data, for example. Alternatively, training data may be styled and used to train the image analyzer.

DEVICES FOR PREDICTING DIABETIC STATUS USING VOICE

Resumen de: US20260106031A1

Provided is a computer-implemented device for generating a type-Il (T2DM) diabetic status prediction, including: a memory comprising a diabetic status prediction model; and a processor in communication with the memory, the processor configured to: receive a voice sample from the subject; extract at least one voice biomarker feature value from the voice sample for at least one predetermined voice biomarker feature; determine the type-II (T2DM) diabetic status prediction for the subject based on the at least one voice biomarker feature value and the diabetic status prediction model; and output, to an output device, the type-II (T2DM) diabetic status prediction for the subject or an output based on the diabetic status prediction.

ADJUSTABLE IMPLANT, SYSTEM AND METHODS

Nº publicación: US20260102187A1 16/04/2026

Solicitante:

NUVASIVE SPECIALIZED ORTHOPEDICS INC [US]

Resumen de: US20260102187A1

0000 Aspects of the disclosure relate to an adjustable implant configured to be implanted into a patient that includes an adjustable portion moveable relative to a housing. The adjustable implant may include various smart components for enhancing operation of the implant. Smart components may include a controller for managing operations and a transducer for communicating ultrasound data with an external interface device. Additional smart components may include a load cell within the housing for measuring an imparted load; a sensor for measuring angular position of the adjustable portion; a dual sensor arrangement for measuring imparted forces; a reed switch; a half piezo transducer; and an energy harvester.