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411
resultados
Última actualización
11/09/2026 [07:22:00]
Resultados 100 a 125 de 411
Resumen de: CN122666012A
本发明公开了一种异质结构多孔稀土镁合金骨支架的激光增材制造方法，包括：建立三维模型，并对其进行分层切片处理；选用稀土镁合金球形粉末，在氩气保护气氛中，采用激光粉末床熔融技术，通过周期性切换激光工艺参数，逐层交替成形粗晶层与细晶层，得到异质结构多孔稀土镁合金骨支架。本发明通过设计与交替施行两种特定的工艺参数组合，并精确控制各自连续沉积的层数，实现对粗晶区与细晶区的占比及粗晶/细晶异质界面的厚度的主动调控，从而完成对整体层状异质结构构型的精确设计，显著提升稀土镁合金的强韧性匹配，有效解决传统均质镁合金强塑性倒置的难题，在承重骨修复支架等领域具有重要的临床应用价值。
Resumen de: CN119277988A
Embodiments of methods, systems, and/or devices facilitate dynamic optimization of oxygen saturation target ranges for preterm infants in a manner that personalizes the physiological state of the preterm infant. In an exemplary embodiment, an oxygen saturation target is dynamically set by monitoring a heart rate of a preterm infant and/or determining a pulmonary elasticity measurement (PRM) and adjusting an oxygen saturation target range of the preterm infant. In various embodiments, heart rate variability measurements and/or PRM are evaluated according to a preset threshold, and if the heart rate variability measurements and/or PRM reach or exceed the preset threshold, the oxygen saturation target range is adjusted. Embodiments of the present disclosure may also optionally readjust the oxygen saturation target range at fixed time intervals based on alerts communicating the oxygen saturation target range and/or based on heart rate variability measurements and/or PRM.
Resumen de: EP4785875A1
Systems and methods for estimating an incident angle and trajectory of therapy devices within Intra-cardiac Echocardiography (ICE) images in real time in order to provide guidance for ICE manipulation to maintain continuous therapy device tip visibility. An ICE imaging sequence is acquired. A pre-trained ultrasound foundation model is used to extract spatial and temporal features in the sequence of ICE images. A transformer based temporal deep learning model is used that integrates the extracted spatial while incorporating historical passing points and angular information to in order to track the catheter tip within the ICE imaging plane. The tip tracking transformer based temporal deep learning model improves upon existing incident angle and trajectory model estimations in ICE procedures by improving prediction accuracy and consistency.
Resumen de: WO2025038108A1
In the disclosed systems and methods for characterizing a cancer condition of a tissue in a subject, a computer system inputs information into an ensemble model. The information includes, for each respective class of radiomics features in a plurality of classes of radiomics features, a corresponding value for each respective radiomic feature in a corresponding plurality of radiomics features of the respective class of radiomics features obtained from a medical imaging dataset. The ensemble model comprises a plurality of component models. The computer system obtains as output from each respective component model in the plurality of component models a corresponding component prediction for the cancer condition, thereby obtaining a plurality of component predictions for the cancer condition. The computer system combines the plurality of component predictions to obtain as output of the ensemble model a characterization of the cancer condition.
Resumen de: US2024058066A1
A surgical planning system may be configured to predict a relationship between two or more bones, including adjoining and/or non-adjoining bones of a patient. The system may be configured to select a representative bone model associated with a bone in response to comparing the representative bone model to a patient bone model associated with the bone of a patient. The system may be configured to determine at least one patient characteristic based on a relationship of the representative and/or patient bone model to another bone model, which may be associated with an adjoining or non-adjoining bone. A method of planning a surgical procedure is also disclosed.
Resumen de: CN116456971A
The present invention relates, in some aspects, to pharmaceutical dosage forms having a swellable component that expands the overall size of the pharmaceutical dosage form in the stomach, alone or in combination with one or more other components of the pharmaceutical dosage form. The pharmaceutical dosage form is configured to stay in the stomach for an extended period of time (e.g., a period of at least about 24 hours) based on an increase in size of the pharmaceutical dosage form in the stomach. The pharmaceutical dosage forms described herein are formulated to release a drug during at least a portion of the gastric residence period. In other aspects, the invention relates to methods of design, methods of preparation (e.g., using three-dimensional printing), and methods of delivering a drug into an individual, relating to the pharmaceutical dosage forms described herein.
Resumen de: CN122665200A
本发明属于生物医用材料技术领域，尤其为一种PDA/MXene功能化3D打印PPC/PBS可降解生物膜及其制备方法。包括PC/PBS双层可降解基膜，所述PC/PBS双层可降解基膜的表面沉积有PDA/MXene功能层，所述PC/PBS双层可降解基膜通过FDM 3D打印形成双层结构。本发明通过在3D打印PPC/PBS双层基膜表面构建PDA/MXene功能层，提高膜表面亲水性和界面活性，使材料由单纯屏障膜转变为具有主动成骨调控能力的功能化生物膜。本发明利用PDA/MXene功能层调节巨噬细胞炎症表型，降低促炎因子表达，提高抗炎修复相关因子表达，并促进内皮细胞迁移、小管形成及成血管相关基因表达，从而有利于建立适合骨再生的免疫‑血管微环境。
Resumen de: US2023146295A1
0000 Embodiments herein relate to an implant for insertion into a patient. The implant comprises a plurality of unit cells arranged to form a three-dimensional lattice structure, the three-dimensional structure comprising a resting volume of the implant. The plurality of unit cells are arranged to form a porous network of the three-dimensional structure, and wherein the three-dimensional structure is a reversibly compressible three-dimensional structure, wherein a bulk porosity of the three-dimensional structure of the implant is at least 50%. Also disclosed is a method of tissue reconstruction or tissue augmentation. The method comprises implanting into the body of a subject an implant of the disclosure.
Resumen de: KR20260130747A
본 개시의 일 실시예에 따라 컴퓨팅 장치에 의해 수행되는, 압박 밴드를 활용하여 사용자의 근육 상태를 모니터링하는 방법이 개시된다. 상기 방법은, 상기 사용자의 신체 일부를 압박하고, 생체 신호를 측정하는 압박 밴드로부터 생체 신호 정보를 획득하는 단계; 상기 생체 신호 정보를 분석하여 상기 사용자의 근육 상태를 분석하는 단계; 및 상기 분석된 근육 상태 정보에 기초하여 상기 사용자의 신체 움직임과 관련된 피드백 정보를 생성하는 단계를 포함할 수 있다.
Resumen de: EP4776504A2
A hookah device which attaches to a hookah. The hookah device comprises a plurality of ultrasonic mist generator devices for generating a mist for inhalation by a user. The hookah device comprises a driver device which controls the mist generator devices to maximize the efficiency of mist generation by the mist generator devices and optimize mist output from the hookah device.
Resumen de: WO2025036834A1
The invention relates to a method for producing a dental restoration (12) from at least one material of a first material type. In the process, one region of the dental restoration (12) made of the material of the first material type comprises at least two portions of different colours and at least two portions of different colour brightness. The method comprises providing a first starting material (M1) having a first colour, a first colour brightness, and a first opacity. The method also comprises providing a second starting material (M2) having a second colour, a second colour brightness, and a second opacity. The region of the dental restoration (12) is then constructed from the material of the first material type by three-dimensionally arranging a plurality of volume segments, wherein each volume segment is formed exclusively from one or more selected from the first starting material (M1) and the second starting material (M2). The invention also relates to a device (10) for producing a dental restoration (12). The invention also relates to a use.
Resumen de: WO2016172699A1
Methods of preparing a delivery system are described. Each method uses a first and second printing materials. The second printing material contains an active material such as a fragrance, flavor, malodor counteracting agent, and mixture thereof.
Resumen de: KR20260130174A
본 발명은 이중극 전기방사와 4축 3D 프린팅을 활용한 인공 혈관용 스캐폴드의 제조 방법으로, 보다 구체적으로는 고분자 용액을 이중극 전기방사하여 생성되는 나노 섬유를 희생재료에 균일하게 배열시켜 내강이 형성된 나노 섬유 구조를 제조하고, 제조된 나노 섬유 구조에 4축 3D 프린터를 활용하여 나선형 패턴을 형성시킴으로써 조직 재생에 유리하면서 내구성이 향상된 인공 혈관용 스캐폴드를 제조할 수 있는 방법에 관한 것이다.
Resumen de: CN122647224A
本发明涉及口腔修复材料技术领域，公开了一种氧化锆义齿精准智造及快速戴牙工艺，包括：获取数字切削的半烧结义齿初胚；置于烧结炉进行三阶等温相变烧结，依次经过动态排胶、基于几何特征参数设定的等温表面扩散以及致密化烧结；在随炉降温至特定温度窗口时通入湿空气，使水分子解离吸附生成表面羟基；随后立即通入极干燥气体强制置换排空水汽并降至室温。临床戴牙时，不对成品义齿进行椅旁喷砂预处理，直接涂布含磷酸酯基团的树脂水门汀完成交联固化。本发明利用等温驻留消除热应力降低收缩形变，原位气相活化建立高强度化学粘接并简化操作，强制扫气避免水热降解，实现了义齿的精确就位与快速稳定粘接。
Resumen de: WO2025164130A1
Provided are: a curable composition for three-dimensional stereolithography, which contains 100 parts by mass of a polymerizable monomer component (A), 40-400 parts by mass of an inorganic filler (B), 0.01-5 parts by mass of a photoinitiator (C), and 0.01-2.5 parts by mass of an activation light absorber (D), and in which 10-90 mass% of the inorganic filler (B) is contained as an organic-inorganic composite filler (E), the value of light scattering index Sc serving as an index of the proportion of light scattered laterally when being irradiated with activation light is 10% or less, and the rate of transmission for activation light in a state prior to being optically cured is 1-50%; and a method for producing the curable composition for three-dimensional stereolithography. The present invention also provides a method for producing a three-dimensional stereolithographic product and a method for producing a dental restoration article, in both of which said curable composition for three-dimensional stereolithography is used.
Resumen de: US20260252172A1
An electrocorticographic interface device includes a flexible thin-film electrode array formed on a biocompatible substrate such as polyimide, the electrode array having a plurality of recording electrodes and interconnect lines patterned on the biocompatible substrate, and the flexible thin-film electrode array further includes an array of perfusion holes distributed across the biocompatible substrate.
Resumen de: WO2024263308A1
The present discloser provides methods and systems related to a medication container that may be locked using a locking mechanism. In one exemplary method, a request from a user may be received by a medication provider for a medication. The medication may be placed in a medication container with a locking mechanism that is operable to lock and unlock the medication container. The medication container may be locked using the locking mechanism. The locked medication container with the medication within may be provided to the user. Subsequent to providing the locked medication container to the user, a request may be received from the user to access the medication in the medication container. A credential may be sent to the user that is usable, via the locking mechanism, to unlock the medication container. The user may then input the credential into the locking mechanism to unlock the medication container and access the medication therein.
Resumen de: WO2025137128A1
The present disclosure provides polymerizable composition that can produce desirable stain resistant polymeric materials, polymer compositions, and/or photo-curable resins. Further provided herein are methods of producing polymerizable compositions, resins, devices, and polymeric materials. Also provided herein are methods of using polymerizable compositions, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.
Resumen de: WO2025038830A1
Additive manufacturing methods, additive manufacturing systems (100), support material for additive manufacturing, and products thereof are provided. For example, the additive manufacturing methods includes depositing a structure material into a support material (108) based on a first computer model of an object, thereby forming a first portion of the object in the support material. The structure material exhibits a viscosity in a range of 1 mPa*s to 5000 mPa*s (1 cP to 5,000 cP) at 25 degrees Celsius. The support material exhibits a density in a range of 1.05 g/mL to 3 g/mL. The method includes repeating the depositing of the structure material as necessary to additively form the object.
Resumen de: WO2025141425A1
A bioprinted liver model with a vascular system consisting of layers and comprising at least one flow channel in which: the first two layers forming the base of the model are 100% filled with bioink, and wherein layer 1 is positioned at an angle of 0° to the flow channel and layer 2 is positioned at an angle of 90° to the flow channel, the inner layers of the model are filled from 20% to 100% with bioink, wherein the inner layers comprise a centrally located at least one flow channel, the perimeter of which is printed with 100% filling and in which every inner layer is arranged at an angle of 60° with respect to the previous layer, the last two layers enclosing the model: the penultimate and the last layer are 100% filled with bioink and wherein the penultimate layer is arranged at an angle of 0° with respect to the flow channel and the last layer is arranged at an angle of 90° with respect to the flow channel, wherein the bioink used is based on natural polymers, synthetic polymers, methacrylated derivatives of natural polymers or mixtures thereof. A method for manufacturing the liver model and the use thereof.
Resumen de: WO2026177387A1
According to an embodiment of the present disclosure, a wearable electronic device may comprise: a housing having a ring shape; a plurality of pressure sensors spaced apart from each other in an inner space of the housing; at least one processor including processing circuitry; and a memory for storing instructions. According to an embodiment, the instructions, when executed individually or collectively by the at least one processor, may cause the wearable electronic device to obtain a plurality of pressure values through the plurality of pressure sensors. According to an embodiment, the instructions, when executed individually or collectively by the at least one processor, may cause the wearable electronic device to compare the plurality of obtained pressure values. According to an embodiment, the instructions, when executed individually or collectively by the at least one processor, may cause the wearable electronic device to determine, on the basis of a result of the comparison, that pressure has been generated according to the size of the finger of a user wearing the wearable electronic device, if the difference between the plurality of pressure values is within a designated range. In addition to various embodiments disclosed in the present document, other various embodiments are possible.
Resumen de: US20260253505A1
0000 A system and method for measuring and assessing cognitive abilities of a user are disclosed. The method includes generating an individualized assessment protocol comprising a plurality of tasks each configured to evaluate cognitive mental specification. The method also includes the user selecting at least one task tasks using a semi-random process. The method further includes displaying a task-specific interface to present the selected task to user. The method includes receiving user responses to the task along with associated parameters. The method includes transmitting an individualized performance score table to a server. The method also includes processing the individualized performance scores using a population database, a neural network classifier, and regression models, which adjust their parameters based on the received scores. The method further includes computing individualized assessment scores to generate a profile of cognitive mental abilities. The method also includes transmitting profile of cognitive mental abilities to user device.
Resumen de: WO2026178535A1
Somatic instability (SI) in the mutant HTT allele is a high value therapeutic target for Huntington's Disease (HD). However, rates of SI and the speed of HD progression vary widely with inherited germline CAG repeat lengths across the HD patient population. Understanding this variability and projecting the treatable range of patients for SI-directed therapies is important to their design, preclinical development, and conferring optimal benefit to HD patients. A computational model and related method(s) track the percentage of healthy medium spiny neurons (MSNs) across the lifetime of HD patients. Changes in MSN survival are predicted based on an exemplary SI-directed interventional gene therapy. The range of treatable patients is also projected. The flexible framework provided by the computational model and related method(s) enables therapeutic performance prediction and projecting outcomes across the HD patient population and furthermore, serves as a valuable tool for defining the target populations for SI-directed therapies.
Resumen de: US20260248538A1
A bone anchoring device for coupling a rod to bone includes an anchoring element with a shank and a head, a receiving part having a central axis, a channel for receiving the rod, and an accommodation space for accommodating the head of the anchoring element, and a pressure element positionable at least partially in the accommodation space to exert pressure on the head. The pressure element is configured to extend to an axial position that is lower than an axial position of a portion of the head having a greatest diameter.The head is pivotable relative to the receiving part, and has a first cooperating surface spaced apart axially from a free end of the head that is engageable with a second cooperating surface that is separable from the pressure element to limit pivoting of the head relative to the receiving part to a single plane.
Nº publicación: US20260249002A1 27/08/2026
Solicitante:
DATADOSE LLC [US]
DATADOSE, LLC
Resumen de: US20260249002A1
An intelligent dosing platform incorporating comprehensive social media integration and patient support network capabilities for injectable medication administration. The platform includes social media interface modules configured to facilitate medication-related communications across multiple social platforms, dosage detection modules that automatically trigger social media notifications and support group communications upon medication administration events, and patient network modules that connect patients with support groups and other patients with similar medication regimens. The system features agentic social network modules utilizing personal data assistants, personal LLM agents for automated content generation and scheduling management, and personal IoT network devices for enhanced social graph updates. Privacy management modules ensure HIPAA compliance while enabling user-controlled sharing of medication milestones and treatment achievements. Support group coordination modules facilitate virtual meetings and peer communications, while notification customization modules provide personalized updates for family members and caregivers based on detected medication administration events.
BOPI
Sede Electrónica
