Alerta

METHOD OF AND SYSTEM FOR DETERMINING AND CUSTOMIZING MEDICATION DELIVERY BASED ON MEDICATION SENSITIVITY

Resumen de: AU2025231452A1

Disclosed is a method of determining sensitivity by a patient to a medication delivered at a delivery frequency including perturbing the delivery amount by a perturbation amount at a perturbation frequency, defining a perturbation signal, measuring a patient response to the perturbation, and recovering the effect of the perturbation. Also disclosed is a system for determining sensitivity by a patient to a medication including a processor configured for the method.

CLINICIAN PROGRAMMER WORKFLOW AUTOMATION FOR IMPLANTABLE MEDICAL DEVICES

Resumen de: AU2025219161A1

The present disclosure relates to stimulation systems, comprising, e.g., an implantable medical device (IMD), such as an implantable pulse generator configured to deliver electrical stimulation to one or more nerves of a subject, or an implantable pump configured to administer one or more active agents. In some aspects, the IMD is configured to store one or more clinical state parameters (e.g., a clinical workflow stage) and/or to advertise or transmit the stored one or more clinical state parameters to a clinician programmer device. One or more settings of the IMD, and/or parameters of the administration of electrical stimulation or the active agent(s), may be set based on the one or more clinical state parameters (e.g., a clinical workflow stage), e.g., either automatically or based on instructions provided by the clinician programmer device.

POSITIONER FOR ORTHODONTIC ALIGNER

Resumen de: WO2026177259A1

The present invention relates to a positioner for an orthodontic aligner. The positioner comprises a body (120) having a three-dimensional shape, provided with an adhesive surface (126), and having a through-hole (129) formed on one side and passing through in a transverse direction, and is fixed to teeth by attaching the adhesive surface (126) to the teeth. On the basis of teeth arrangement data obtained by scanning in a state in which the body (120) is fixed to the teeth, the positioner can guide the positions for mounting the body (120) attached to the teeth to be corrected and orthodontic means formed to correspond to each of the teeth. Furthermore, by hanging a wire on the through-hole (129) and pushing or pulling the teeth, preliminary correction can be performed prior to correcting the teeth using the orthodontic means.

System and Method for Populating Electronic Medical Records with Wireless Earpieces

Resumen de: US20260253694A1

0000 A system, method and wireless earpieces for populating an electronic medical record utilizing wireless earpieces. The sensor measurements are analyzed. The sensor measurements are associated with the electronic medical record of the user. The electronic medical record of the user is populated with the sensor measurements. Communications including the electronic medical record are communicated.

DROPLET DEVICE WITH FLOW ELEMENT

Resumen de: US20260249023A1

0000 An electronically actuated droplet delivery device includes a housing having an airflow passage extending from an aperture plate to a mouthpiece and a flow element at an airflow entrance side of the housing. A fluid reservoir is in fluid communication with the aperture plate, which has a plurality of openings, and an electronic actuator vibrates the aperture plate at a frequency to generate an ejected stream of droplets. A sensor in fluid communication with the airflow passage detects an inhalation flow condition and triggers actuation of the aperture plate.

MICROENVIRONMENTAL MONITORING UTILIZING DIFFERENT TYPES OF SENSING DEVICES IN A BODY AREA NETWORK ASSOCIATED WITH A SUBJECT

Resumen de: US20260248389A1

0000 An apparatus comprises a processing device implementing a body area network (BAN) controller for a BAN associated with a subject. The processing device is configured to pair first and second sets of sensing devices with the BAN associated with the subject, the first set of sensing devices configured for physiologic monitoring of the subject and the second set of sensing devices configured for contextual monitoring of an environment of the subject. The processing device is also configured to enable data sharing of physiologic monitoring data obtained from the first set of sensing devices and contextual monitoring data obtained from the second set of sensing devices utilizing the BAN associated with the subject, and to determine, based on the physiologic monitoring data obtained from the first set of sensing devices and the contextual monitoring data obtained from the second set of sseennssiinngg devices, microenvironmental monitoring parameters associated with the subject.

Rapid 3D-Bioprinting of Microfluidic Vascular Tissue Models

Resumen de: US20260250614A1

0000 A novel vascular tissue model is disclosed. The model uses a rigid 3D printed scaffold. This scaffold includes one or more scaffold microfluidic channels, two or more inlets, and a central chamber. The central chamber contains a hydrogel, and the hydrogel includes a hydrogel microfluidic channel.

COMPUTER-AIDED DIAGNOSIS SYSTEM

Resumen de: US20260253212A1

0000 A system for intelligent surveillance of attention and recognition of computer-aided diagnosis system outputs. The system can include an endoscope, a computer-aided diagnostic module, a camera, a memory, and a controller. The endoscope can include an elongated member that can include a distal portion and a process camera attached to the distal portion. The process camera can capture a video stream during a procedure. The computer-aided diagnostic module can be configured to detect an abnormality within the video stream using a diagnostic algorithm and transmit a signal. The controller can be configured to determine a gaze location of the doctor during the procedure using a gaze algorithm, determine whether the doctor looked at the detected abnormality by comparing the signal from the computer-aided diagnostic module and the gaze location of the doctor, and trigger a countermeasure based on determining that the doctor did not look at the detected abnormality.

MACHINE LEARNING FOR OBJECT TRACKING

Resumen de: US20260248561A1

The present disclosure provides systems and methods capable of determining a roll angle of a medical instrument in real time based on one or more medical images that include the medical instrument. In different versions, the images may be, for example, fluoroscopic, ultrasound, and/or video. The roll angle may be determined using one or more machine learning models. Other degrees of freedom may also be determined. The roll angle (and potentially other degrees of freedom) may be used in visualizations that guide a user of the medical instrument. The visualization may employ various displays and/or headsets, and may be used with an augmented reality (AR) system, a mixed reality (MR) system, a virtual reality (VR) system, an extended reality (XR) system, and/or a spatial computing system.

TECHNIQUES FOR DETECTING ATRIAL FIBRILLATION

Resumen de: US20260248438A1

Methods, systems, and devices for atrial fibrillation (AFib) detection are described. A method may include acquiring physiological data collected from a user via a wearable ring device, the physiological data including temperature data and motion data, and identifying that a measurement trigger condition for AFib has been satisfied based on the temperature data satisfying a temperature threshold and the motion data satisfying a motion threshold. The method may include sampling photoplethysmogram (PPG) data for the user via the wearable ring device based on identifying satisfaction of the measurement trigger condition, and classifying one or more AFib states based on the sampled PPG data. The method may further include causing a GUI of a user device to display an indication of the one or more AFib states.

CLINICAL DATA ANALYSIS

Resumen de: US20260253729A1

A method for clinical data analysis includes receiving a first 3D representation that is representative of clinical data. The first three-dimensional (3D) representation includes one or more mesh elements. The method includes computing one or more mesh element features for the one or more mesh elements and providing the one or more mesh element features as an input to a first machine learning (ML) module. The method includes executing the first ML module to encode the first 3D representation into one or more latent representations and providing the one or more latent representations to a second ML module that is different from the first ML module. The method includes executing the second ML module to classify the clinical data represented in the first 3D representation into at least one predicted classification label.

METHODS AND SYSTEMS FOR CHARACTERIZING POROSITY OF ADDITIVELY MANUFACTURED BONE SCAFFOLDS

Resumen de: US20260253203A1

A method for characterizing a bone tissue scaffold produced by an additive manufacturing process is provided. An image of the bone tissue scaffold is first captured and a boundary of the bone tissue scaffold is determined. One or more surface features of the bone tissue scaffold are subsequently detected using an edge detection algorithm, with the one or more surface features including one or more pores and/or one or more highlights. Edges that correspond to a pore using a pore filling algorithm are identified and the surface porosity of the bone tissue scaffold is thereby mapped. Systems for characterizing a bone tissue scaffold are also provided and make use of an image capture device for capturing an image of the bone tissue scaffold, as well as a processor for analyzing the image via instructions stored on the processor.

PHOTOCURABLE REINFORCEMENT OF 3D PRINTED HYDROGEL OBJECTS

Resumen de: US20260248919A1

The present disclosure provides reinforced hydrogel structures, methods of reinforcing hydrogel structures, and methods of treating ischemic disorders using the reinforced hydrogel structures.

Polymeric Structures Having a Micro-Void Space and Systems and Methods for Making Same

Resumen de: US20260249546A1

Aspects of the present disclosure include methods for making a polymeric structure having a micro-void space. Methods according to certain embodiments include irradiating a polymerizable composition positioned between a build elevator and a build surface to generate a polymerizable composition having a polymerized region of the polymerizable composition having a micro-void space in contact with the build elevator and a non-polymerized region of the polymerizable composition in contact with the build surface, displacing the build elevator away from the build surface, contacting the generated micro-void space with a non-reactive composition and repeating in a manner sufficient to generate a polymeric structure having a resolved micro-void space. Systems for preparing a polymeric structure according to the subject methods are also described. Polymeric structures having a resolved micro-void space such as where the micro-void space is filled with a non-polymerizable composition are also provided.

INTRAORAL SCANNER WITH AN ANTENNA

Resumen de: US20260248374A1

Embodiments can relate to an intraoral scanner including a projector unit configured to emit light at least onto a dental object of a patient, and an image sensor configured to acquire reflected light from at least the dental object. The scanner includes a wireless interface configured to communicate with an external device, where the communication may include 2D image data and/or 3D image data processed or raw. The scanner includes a housing accommodating the projector unit and the image sensor, and wherein the housing includes a first end and a second end, and the projector unit and the image sensor are arranged closer to the first end, and an antenna of the wireless interface is arranged closer to the second end, and wherein during a scan of an oral cavity the first end is located inside the oral cavity and the second end is not located within the oral cavity.

ILLNESS DETECTION BASED ON NERVOUS SYSTEM METRICS

Resumen de: US20260248462A1

Methods, systems, and devices for illness detection are described. A method may include receiving heart rate variability (HRV) data associated with a user from a wearable device, the HRV data collected via the wearable device throughout a first time interval and a second time interval subsequent to the first time interval. The method may include inputting the HRV data into a classifier, and identifying a satisfaction of deviation criteria between a first subset of the HRV data collected throughout the first time interval and a second subset of the HRV data collected throughout the second time interval. The method may include causing a graphical user interface (GUI) of a user device to display an illness risk metric for the user based on the satisfaction of the deviation criteria, the illness risk metric associated with a relative probability that the user will transition from a healthy state to an unhealthy state.

METHOD AND DEVICE FOR ASSESSMENT OF PERIPHERAL NEUROPATHY

Resumen de: US20260248441A1

0000 The invention relates to ways for determining, whether or not a person suffers from peripheral neuropathy. In order to make the generation of data for the determination easy for the person, the invention provides that sensor data from foot bottom pressure sensors (11, 12) used by the person to control computer games is used to determine, whether or not a person suffers from peripheral neuropathy.

Classification of tumor microenvironments

Resumen de: AU2026205056A1

The disclosure provides population and non-population-based classifiers to categorize patients and cancers. The population-based classifiers disclosed integrate signatures, i.e., global scores related to the expression of genes in particular gene panels. The non-population- based classifiers are generated using machine-learning techniques (e.g., regression, random forests, or ANN). Each type of classifier stratifies patients and cancers according to tumor microenvironments (TME) as biomarker-positive or biomarker-negative, and treatment decisions are then guided by the presence/absence of a particular TME. Also provided are methods for treating a subject, e.g., a human subject, afflicted with cancer comprising administering a particular therapy depending on the classification of the cancer’s TME according to the disclosed classifiers. Also provided are personalized treatments that can be administered to a subject having a cancer classified into a particular TME, and gene panels that can be used for identifying a human subject afflicted with a cancer suitable for treatment with a particular therapeutic agent. un u n

HARDWARE-ACCELERATED NEUROMORPHIC SYSTEM FOR REAL-TIME OUTCOME MONITORING, MULTIMODAL ASSET GOVERNANCE, AND REGULATORY COMPLIANCE FOR TRANSPOSABLE SELF-RELIANT ENTITIES

Resumen de: US20260254923A1

A hardware-accelerated neuromorphic system and method are provided for real-time outcome monitoring of transposable transformations within an enterprise environment. The system utilizes a Neuromorphic System-on-Wafer (SoW) architecture comprising a plurality of Synaptic Processing Units (SPU) and AI accelerators to facilitate low-latency processing of neural correlates of consciousness (NCC). A shared synaptic chip interface identifies brain activity in a biological substrate and audits identified neural correlates against stored transformation blueprints and international regulatory standards, such as Wheaton System Engineering Standards, to validate desired transformational outcomes. The system further incorporates multimodal asset governance, where transformational outcomes may be collateralized by labor contracts or physical assets, ensuring identity continuity during distal reconstitution into mechatronic substrates.

MEDICAL DEVICES AND METHODS

Resumen de: US20260253722A1

0000 Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned in vivo analyte sensor automatically or upon request from a user.

AN ORTHOPAEDIC IMPLANT

Resumen de: WO2026175863A1

The present invention relates to a 3D-printed orthopaedic implant (201, 301, 401) comprising a non-porous support portion (205, 305, 405) and a porous osteoconductive scaffold (203, 303, 403), wherein the porous osteoconductive scaffold forms at least 60% of the volume of the 3D-printed orthopaedic implant, and the 3D-printed orthopaedic implant comprises at least one discrete hollow tunnel (207a-e, 307a-c, 407a-c) extending into the osteoconductive scaffold, each discrete hollow tunnel being independently configured to allow insertion of a solid osteoinductive filament (101a, b) therein, and wherein each discrete hollow tunnel independently has: a volume of 7% or less of the 3D-printed orthopaedic implant; a substantially uniform cross-section; and a length that is at least three times greater than its width. A solid osteoinductive filament operable to be introduced into the 3D-printed orthopaedic implant, and a kit formed therefrom, are also encompassed.

SYSTEMS AND METHODS FOR SUPPORTING ASSEMBLY OF A COLLECTION OF OBJECTS

Resumen de: WO2026176339A1

The present disclosure provides automated systems and methods for supporting assembly of a collection of objects used for a task. In certain embodiments, the systems and methods support assembly of surgical trays for use in a surgical or other medical setting. A method may comprise receiving images from a camera. The images may be analyzed to automatically identify objects in the images and to automatically determine that the objects have been placed in a container. A container inventory corresponding to a task for the container may be updated that the objects have been placed in the container. Machine vision modules and checking a weight of a container may both aid in determining whether the objects have been placed in the container. Thus, the method may automate the process of assembly of a collection of objects that may lead to a reduction of errors.

MANUALLY ROTATED MEDICAL IMAGING SYSTEMS AND ASSOCIATED METHODS

Resumen de: WO2026178497A1

Systems, methods, and devices for medical imaging are disclosed herein. In some embodiments, a method for imaging an anatomic region includes receiving, from a detector carried by an imaging arm of a mobile C-arm apparatus, a plurality of 2D images of the anatomic region. The images can be obtained during a non-isocentric manual rotation of the imaging arm. The method can also include receiving data indicative of a plurality of poses of the imaging arm during the manual rotation. The method can further include generating, based on the 2D images and the data, a 3D reconstruction of the anatomic region.

PHYSIOLOGIC RESPONSE MONITOR MOUTH WEARABLE

Resumen de: US20260248442A1

0000 Various components, methods, and systems are provided herein for monitoring physiological responses associated with force-impact events using a mouth-wearable sensing device positioned within an oral cavity of a subject. In some embodiments, the device integrates inertial sensing, force sensing, temperature sensing, and optical physiological sensing on a compact intraoral substrate and transmits physiological data wirelessly to an external computing device for analysis and reporting. In some embodiments, the mouth-wearable sensing device is customized using intraoral scan data to generate a three-dimensional oral cavity model and to position one or more sensors to align with anatomical landmarks when worn.

ALLERGEN TEST PATCHES FOR AUTOMATED ALLERGIC CONTACT DERMATITIS PATCH TESTING

Nº publicación: WO2026178496A1 27/08/2026

Solicitante:

MAYO FOUND MEDICAL EDUCATION & RES [US]
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Resumen de: WO2026178496A1

An allergen test patch includes a patch substrate having a top surface and a bottom surface, at least one allergen well coupled to the bottom surface of the patch substrate, and a border removably coupled to and surrounding the patch substrate. The border has a top surface and a bottom surface. An adhesive is disposed on the bottom surface of the border to adhere the border to a skin surface of a subject, thereby removably coupling the patch substrate to the skin surface of the subject. When the border is adhered to the skin surface of the subject, removing the patch substrate from the border retains the border on the skin surface of the subject. This design allows for improved allergen testing by maintaining a defined test area on the skin after removal of the allergen-containing substrate.