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METHODS AND SYSTEMS FOR THE PREPARATION OF PHARMACEUTICAL DOSAGE FORMS

Resumen de: WO2026002911A1

According to an example aspect of the present invention, there is provided a method for preparing pharmaceutical dosage forms, the method comprising: inserting a dispenser into a thermal end; wherein the dispenser comprises a first tag and a dispensable dispersion comprising an active pharmaceutical ingredient (API), wherein the thermal end is detachably attachable to a liquid handling device, reading the first tag with a first reader to obtain a dispenser identification code, sending, by the liquid handling apparatus, the obtained dispenser identification code to a server comprising a database comprising at least one previously obtained dispenser identification code, verifying, by the server, the obtained dispenser identification code against the at least one previously obtained dispenser identification code to confirm the identity of the dispenser, and dispensing, by the liquid handling apparatus, at least some of the dispensable dispersion onto a dispensing target to form one or more dosage forms.

SCAFFOLD FREE CARTILAGE IMPLANTS

Resumen de: WO2026003088A1

The invention relates to methods of preparing an implant for bone repair, the method comprising the steps of expanding periosteum derived cells, mixing the expanded periosteum derived cells with a partially cross-linked sodium alginate solution, forming the alginate solution and the cells into a shaped construct, differentiating the cells in the shaped construct towards chondrogenic differentiation, and dissolving crosslinked alginate with a calcium chelating agent.

COUPLING SOLUBILITY ENHANCEMENT AND 3D PRINTING

Resumen de: WO2026002832A1

The present invention relates to a process for producing a pharmaceutical dosage form by combining hot melt extrusion and powder bed fusion selective laser 3-dimensional printing, in particular hot melt extrusion and selective laser sintering 3-dimensional printing (SLS), and a pharmaceutical dosage form manufactured by that process.

APARATUS AND METHOD FOR COHERENT IMAGING AND FEEDBACK CONTROL FOR MODIFICATION OF MATERIALS

Resumen de: EP4306235A2

Methods and systems are provided for using optical interferometry in the context of material modification processes such as surgical laser or welding applications. An imaging optical source that produces imaging light. A feedback controller controls at least one processing parameter of the material modification process based on an interferometry output generated using the imaging light. A method of processing interferograms is provided based on homodyne filtering. A method of generating a record of a material modification process using an interferometry output is provided.

IN-SITU CELLULAR BIOPRINTER

Resumen de: WO2026006038A1

Methods, systems, and apparatus, including computer programs encoded on computer storage media, for bioprinting cellular tissue in-situ. One of the systems includes a device body comprising: a first housing adapted to store one or more tissue repair ingredients; and a second housing for a motor adapted to move at least one tissue repair ingredient from the first housing to a tissue printing head; and the tissue printing head comprising: a printing nozzle adapted to receive the at least one tissue repair ingredient from the first housing and deposit the at least one tissue repair ingredient onto one or more locations of a tissue defect; an ingredient guidance device adapted to direct the at least one tissue repair ingredient toward the one or more locations of the tissue defect; and a removable coupling device adapted to couple the tissue printing head onto a region of the patient.

NOVEL ARTIFICIAL BONE BASED ON PROMOTING NEUROVASCULAR REGENERATION AND PREPARATION METHOD

Resumen de: WO2026000923A1

Disclosed in the present invention are a novel artificial bone based on promoting neurovascular regeneration and a preparation method. The novel artificial bone comprises an artificial bone. The artificial bone is composed of β-tricalcium phosphate, polylactic acid-glycolic acid, a nano magnesium-based powder, and a piezoelectric polymer. The mass ratio of β-tricalcium phosphate to polylactic acid-glycolic acid in the artificial bone is 1:0-1:10. The nano magnesium-based powder and the piezoelectric polymer are mixed to form a piezoelectric composite solution, and the mass ratio of the nano magnesium-based powder to the piezoelectric polymer in the piezoelectric composite solution is 1:1-1:20, such that the surface of the artificial bone is modified by means of the piezoelectric composite solution, thereby forming a piezoelectric coating on the surface of the artificial bone; in this way, when the artificial bone is implanted into a bone defect site and is subject to stress, a charge and potential difference are generated. The present invention not only enhances the strength of the artificial bone, but also promotes the degradation of the artificial bone, stimulates local neurovascular regeneration, promotes the formation of new bone, and achieves the purpose of repairing osteonecrosis and bone defects.

一种骨植入用互穿相结构镁钛复合材料及其制备方法

Resumen de: CN121243467A

本发明公开了一种骨植入用互穿相结构镁钛复合材料，该镁钛复合材料由钛合金材质的增强相和镁或镁合金材质的基体相相互穿插组成，增强相与基体相在三维空间中各自保持连续，且镁钛复合材料的增强相和基体相在径向上均具有梯度结构；本发明还公开了一种骨植入用互穿相结构镁钛复合材料的制备方法。本发明的镁钛复合材料通过将结构设计为增强相和基体相呈三维连续且相互穿插，并在径向上两相均呈现梯度的结构，使得镁钛复合材料植入物与患者骨缺损处健康骨组织实现良好生物力学适配，适用于作为生物医用金属材料领域的骨植入物。

一种用于拇外翻Chevron截骨术的截骨导板

Resumen de: CN121242675A

本发明涉及医疗手术器械技术领域，具体涉及一种用于拇外翻Chevron截骨术的截骨导板，板体、定位部、以及截骨部；其中，板体呈与拇外翻截骨位置骨骼表面轮廓适配的曲面板状结构，板体具有近端面、远端面、以及至少两个侧表面；定位部固定地设置于板体的近端面上，截骨部固定地设置于板体的侧表面上；定位部包括：固定地设置于板体近端面的若干定位凸起结构、以及沿定位凸起结构的中轴线开设于各定位凸起结构上的若干定位孔；其中，各定位孔贯穿板体；本发明的板体与截骨部的曲面贴合设计，确保导板与骨骼表面紧密贴合，定位部通过定位凸起结构与定位孔配合，实现导板临时稳固固定，避免术中偏移；截骨引导结构精准引导截骨。

可光交联和3D打印的两栖类胶原蛋白衍生物

Resumen de: WO2024258349A1

Disclosed herein is a hydrogel precursor formulation that comprises one or both of a methacrylated bullfrog collagen (ColMA) and a methacrylated gelatin (GelMA), where the gelatin is obtained from bullfrog collagen, and a photoinitiator Also disclosed herein is a bioink comprising the aforementioned hydrogel precursor formulation. Further disclosed herein is a kit of parts comprising a ColMA, a GelMA, and a photoinitiator.

SiOC/Si3N4复合陶瓷-钛合金颞下颌关节植入物的3D打印方法

Resumen de: CN121242779A

SiOC/Si3N4复合陶瓷‑钛合金颞下颌关节植入物的3D打印方法，涉及3D打印技术领域，用于制备具有更优耐腐蚀性、耐磨性和生物稳定性的颞下颌关节植入物。包括：S1称粉；S2、混料；S3、搅拌；将步骤S1的级配氮化硅粉体与步骤S2的光敏树脂导入机械搅拌设备内搅拌2h‑3h，得到混合物；S4、均质；将混合物加入均质机中除去有机溶剂获得氮化硅陶瓷浆料；S5、扫描建模；S6、打印；将氮化硅陶瓷浆料置于导入有颞下颌关节植入物模型的3D打印机中，得到颞下颌关节植入物打印件；S7、烧结；S8、装配；将复合氮化硅陶瓷与钛合金基体通过榫卯连接得到SiOC/Si3N4复合陶瓷‑钛合金颞下颌关节植入物。本发明可制备具有更优耐腐蚀性、耐磨性和生物稳定性的颞下颌关节植入物。

一种β-锂辉石与偏硅酸锂共掺杂改性的牙科用二硅酸锂玻璃陶瓷及制备方法与应用

Resumen de: CN121248145A

本发明属于牙科修复材料制造技术领域，具体涉及一种β‑锂辉石与偏硅酸锂共掺杂改性的牙科用二硅酸锂玻璃陶瓷及制备方法与应用。本发明以β‑锂辉石粉体、偏硅酸锂晶种和二硅酸锂母玻璃粉为原料，采用光固化增材制造技术逐层固化浆料，再经脱脂、成核、结晶及液相烧结，同步实现β‑锂辉石粉体偏硅酸锂共掺杂改性，制备得到的β‑锂辉石与偏硅酸锂共掺杂改性的牙科用二硅酸锂玻璃陶瓷具有高致密性、高挠曲强度、高断裂韧性及良好临床适配性等特点。本发明有效克服了传统二硅酸锂玻璃陶瓷断裂韧性低、增材制造陶瓷致密性与强度不足等问题，适用于高精度个性化牙冠、桥体等牙科修复体的制造。

一种4D打印多孔NiTi合金脊柱用仿生骨植入体

Resumen de: CN121243466A

本发明公开了一种4D打印多孔NiTi合金脊柱用仿生骨植入体，本发明涉及仿生骨植入体技术领域，包括植入体主体，所述植入体主体采用含微量元素的多孔NiTi合金通过4D打印技术一体成型；所述植入体主体在植入人体后，能在35‑42℃的体温刺激下发生形状或孔隙率的可控变化，形状回复率≥90%，孔隙率调节范围为±5%‑10%。该4D打印多孔NiTi合金脊柱用仿生骨植入体，通过调控孔隙率与孔径，并沿脊柱力学传导方向设计梯度多孔结构，使弹性模量降低，与人体脊柱松质骨力学特性高度匹配，有效消除应力遮挡效应，减少周围骨萎缩风险；同时，NiTi合金的形状记忆效应可在体温刺激下实现形状/孔隙率可控调整，适配术后脊柱生理曲度变化，提升植入体长期稳定性。

pH响应型金属-多酚改性的3D打印骨修复支架及其制备方法

Resumen de: CN121243485A

本申请公开了pH响应型金属‑多酚改性的3D打印骨修复支架及其制备方法，包括以下步骤：S1、将PLGA溶解于二氯甲烷中，加入β‑TCP纳米颗粒，搅拌形成均匀悬浮液；S2、将单宁酸溶于pH=8.5的Tris‑HCl缓冲液得到TA溶液，与ZnCl2溶液等体积混合，离心清洗3次，冷冻干燥制得Zn‑TA‑MPN纳米颗粒；S3、将Zn‑TA‑MPN纳米颗粒分散于二氯甲烷，与PLGA/β‑TCP悬浮液混合，形成含Zn‑TA‑MPN纳米颗粒的生物打印墨水；S4、将生物打印墨水通过3D打印技术制备成支架，冷冻干燥后得到Zn‑TA/PLGA/β‑TCP支架，然后浸入TA溶液，经过PBS清洗后，再浸入AgNO3溶液，在支架表面形成Ag‑TA‑MPN涂层，得到Zn‑TA/PLGA/β‑TCP@Ag‑TA支架。由此，可用于感染性骨缺损的修复，通过pH响应性释放抗菌及成骨成分，实现感染控制与骨再生的协同治疗。

一种牙科用金属种植导板及其制备方法

Resumen de: CN121242755A

本申请涉及一种牙科用金属种植导板及其制备方法。该包括导板本体，所述导板本体包括牙龈贴合区和种植定位区；其中，所述牙龈贴合区具有与牙槽骨匹配的曲面结构，所述种植定位区设置有与种植体匹配的定位孔，所述定位孔贯穿所述导板本体，在所述定位孔周侧设置有供冷却液流通的散热通道，所述散热通道与所述定位孔连通；所述导板本体采用钛合金粉末和铜粉通过增材制造技术制成。本申请实施例中种植导板兼具高强、轻薄、高效散热、生物兼容、可回收、环保特性，提升牙科种植手术的精准度、安全性和可持续性。

一种数字化3D打印骨成形制作装置及方法

Resumen de: CN121242758A

本申请涉及塑性材料的成型领域，尤其是涉及一种数字化3D打印骨成形制作装置及方法，其包括真空袋和成品模板，真空袋上开设有抽气孔，抽气孔上安装有气泵，成品模板包括第一压块和第二压块，第一压块靠近第二压块的一侧开设有第一成型腔，第二压块靠近第一压块的一侧开设有第二成型腔，第二成型腔的底壁开设有溢出孔；切料组件包括切料板，切料板水平设置，且其沿水平方向滑移安装在第二压块内；补料组件包括补料孔、补料板以及两补料通道，补料孔沿竖直方向开设在第二成型腔的底壁，补料板沿竖直方向滑移安装在补料孔内，补料通道开设在补料孔和溢出孔之间。本申请的目的是为了保障黏性骨的成型质量以及延长黏性骨的使用寿命。

PROBIOTIC SELF-COATING MEDICAL CATHETER AND METHODS OF MAKING

Resumen de: US20260000814A1

Methods of making a probiotic self-coating medical catheter include preparing a probiotic bioink by combining at least one probiotic with a silicone bioink at a weight ratio of 2:1 to 100:1, printing a three-dimensional tubular structure with the probiotic bioink, and heating the three-dimensional tubular structure to a temperature of up to 60° C. to cure the probiotic bioink through hydrosilylation of the silicone bioink to form the probiotic self-coating medical catheter. The at least one probiotic is a non-pathogenic bacteria. A probiotic self-coating medical catheter made according to such method is also provided.

NOVEL POROUS SCAFFOLD AND METHOD FOR MANUFACTURING SAME

Resumen de: US20260000812A1

The present disclosure relates to a porous scaffold having excellent tissue engineering characteristics and a method for preparing the same. The scaffold according to the present disclosure not only can be prepared by a simple process, but also can exhibit a remarkably excellent cell engraftment rate as well as high tensile strength and biocompatibility so that it can be usefully used as a support composition for human body transplantation of various uses, including artificial ligaments and supports for reinforcing the abdominal wall.

PATIENT-SPECIFIC MEDICAL SYSTEMS, DEVICES, AND METHODS

Resumen de: US20260000460A1

Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. In some embodiments, a method includes receiving a patient data set of a patient. The patient data set is compared to a plurality of reference patient data sets, wherein each of the plurality of reference patient data sets is associated with a corresponding reference patient. A subset of the plurality of reference patient data sets is selected based, at least partly, on similarity to the patient data set and treatment outcome of the corresponding reference patient. Based on the selected subset, at least one surgical procedure or medical device design for treating the patient is generated.

REPAIR APPARATUS FOR REPAIRING BONE DEFECTS

Resumen de: US20260000437A1

A repair apparatus for repairing bone defects includes a bioabsorbable scaffold having first and second ends that spans a space between spaced apart first and second bone fragments. The first end of the scaffold envelops an end of the first bone fragment and the second end of the scaffold envelops an end of the second bone fragment.

PROGRESSIVELY FORMED FIBROUS STRUCTURES, AND METHOD AND TOOLING FOR FORMATION THEREOF

Resumen de: US20260002326A1

A forming tool for agglomerating thereon fibers from a slurry, the tool having a first end, a second end, a longitudinal axis, a forming surface and a non-forming surface, wherein the forming surface is perforated with a pattern of fluid passage ports extending from the forming surface to the non-forming surface; wherein the pattern of fluid passage ports demarks a surface area of the forming surface.

INSERTABLE AND PREFABRICATED ATTACHMENTS FOR AN ORAL APPLIANCE

Resumen de: US20260000488A1

A method includes forming a plastic shell that has a hollow feature that includes a cavity. The method further includes inserting an object into the cavity, wherein the object is in a solid state and is preformed and shaped to fit into the cavity prior to the inserting of the object into the cavity, wherein the object provides structural strength to the plastic shell at a location of the hollow feature and does not interfere with a fit of the plastic shell onto a dental arch of a patient, the object having a shape that substantially matches a contour of the cavity prior to being inserted into the plastic shell.

SYSTEMS AND METHODS FOR ORTHODONTIC APPLIANCE PRODUCTION

Resumen de: US20260000486A1

The present disclosure provides systems and methods for orthodontic appliance production. The methods may include determining a baseline thickness of an orthodontic appliance for orthodontically treating teeth of a target subject. The methods may include, for each local point on the teeth of the target subject, determining a movement path of the local point from an initial location of the local point to a target location of the local point. The methods may also include, for each local point on the teeth of the target subject, determining, based on the movement path and the baseline thickness, a target thickness of the orthodontic appliance corresponding to the local point. The methods may further include directing a three-dimensional (3D) printer to integrally produce, based on the target thickness of the orthodontic appliance at each local point, the orthodontic appliance.

3D Bioprinted Tissues and Screening Assays Therewith

Resumen de: US20260002133A1

Disclosed herein are 3D printed vascular tissues and compositions and methods for making the 3D printed vascular tissues. The 3D printed vascular tissues can be used to model vascular tissue damage (e.g., vascular leakage) and in screening assays for agents that cause or inhibit or treat vascular tissue damage.

POROUS STRUCTURE AND METHODS OF MAKING SAME

Resumen de: US20260001125A1

The present disclosure provides methods to improve the properties of a porous structure formed by a rapid manufacturing technique. Embodiments of the present disclosure increase the bonding between the micro-particles 5 on the surface of the porous structure and the porous structure itself without substantially reduce the surface area of the micro-particles. In one aspect, embodiments of the present disclosure improves the bonding while preserving or increasing the friction of the structure against adjacent materials.

BONE DEFECT REPAIR APPARATUS

Nº publicación: US20260000514A1 01/01/2026

Solicitante:

UNIV OF CENTRAL OKLAHOMA [US]
University of Central Oklahoma

Resumen de: US20260000514A1

A repair apparatus for repairing bone defects comprises an intramedullary nail extending into spaced apart first and second bone fragments of the bone defect through the ends thereof. A nanofiber mesh scaffold is disposed about the intramedullary nail and positioned between the ends of the first and second bone fragments.