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一种基于多模态标记的在体闭环三维打印系统及方法、设备

Resumen de: CN122896423A

本发明提供一种基于多模态标记的在体闭环三维打印系统及方法、设备，包括用于获取多模态标记物的信息和内部待打印区域的信息，同时实现各坐标系的转换的影像采集与反馈模块；用于识别标记物的位置的红外相机成像与反馈模块；用于根据误差模型进行动态补偿控制并实现末端执行器的自适应调节的闭环控制模块；用于接收闭环控制模块的指令完成生物材料的在体三维打印的打印执行模块；多自由度机械臂为协作机械臂，协作机械臂端部安装有打印喷头。本发明通过构建多模态标记体系，实现术前医学影像与术中导航信息的统一定位，有效降低多模态配准误差并提高空间映射精度。

一种颌垫及其制作方法

Resumen de: CN122894072A

本申请公开了一种颌垫及其制作方法，涉及牙科矫正用具的技术领域，颌垫包括上颌垫和下颌垫，上颌垫后牙区向对颌方向凸出设置有上定位部，下颌垫后牙区向着对颌方向凸出设置有下定位部，上定位部设置有上定位斜面，下定位部设置有下定位斜面，上定位斜面和下定位斜面能够相互抵触以形成一复合导向配合面；复合导向配合面在近远中方向上由远中向近中倾斜向上延伸；复合导向配合面在颊舌方向上由舌侧向颊侧倾斜朝向近中延伸。本申请中通过上、下定位斜面的相互抵触配合，能够有效防止下颌后退及左右摆动。

一种仿生珊瑚骨植入物及其制备方法

Resumen de: CN122895539A

本发明公开了一种仿生珊瑚骨植入物及其制备方法，涉及医用植入技术领域，创新性地将珊瑚天然的多级孔状结构与骨植入物的承重要求相结合，通过仿生结构设计的方法有效提升了多孔金属锌基架的力学承载性能和降解适配性，成功解决了传统金属锌基骨植入物存在的力学强度不足和支撑失效问题。采用选择性激光熔化技术制备出的多孔锌基仿生珊瑚结构，不仅具有优异的力学适配性，能够提供长期的稳定支撑，还具备良好的生物可降解特性，能够随着骨组织的愈合实现渐进式降解，避免了二次取出手术，在脊柱外科椎间盘置换领域具备良好的应用前景。

整合了服药提醒、通知、确认、记录的自给自足型系统及设备

Resumen de: WO2026126691A1

Problem To provide a simple and self-contained medication-taking management system that does not depend on an external server or device and makes use of built-in reminder and medication-taking confirmation functions to make it possible to take medication as prescribed and to not forget to take medication. Solution The present invention provides a medication-taking management system that comprises pockets (4) that are provided in the surface of a body (1) in seven rows and four columns, LEDs (3) that indicate medication to be taken, a liquid crystal display (LCD) (6), a confirmation button (5) for making medication-taking confirmations, a buzzer (2) that gives audio notifications, an SD card reader (7) that stores data, and an RTC module (12) that manages time. The medication-taking management system also has a built-in control/communication module and can manage a medication-taking schedule, transmit notifications over the internet, etc. The present invention thereby achieves a simple and practical system that supports patient compliance with medication-taking.

神经退行性疾病及前驱障碍的判定方法及判定装置

Resumen de: WO2025197838A1

The present invention assesses the risk of a neurodegenerative disease, and a precursor disorder for the neurodegenerative disease, using a saliva sample. An assessment device 10 comprises an inference unit 12 that inputs data of the saliva microbiome composition of a subject to each of a plurality of prediction models and obtains an inference result from each of the plurality of prediction models, and an assessment unit 13 that combines the plurality of inference results to assess the disease state of the subject. Each of the plurality of prediction models is machine-learned so as to stratify the disease state of the subject when inputting the data of the saliva microbiome composition of the subject using, as teacher data, the data of the saliva microbiome composition and the disease state of a neurodegenerative disease or a precursor disorder of the neurodegenerative disease. Each of the plurality of prediction models infers mutually different combinations of disease states.

用于对牙齿的三维结构进行估计的装置

Resumen de: WO2025191493A1

Device for estimating the three-dimensional structure of teeth inside a mouth, comprising : - a central control unit, - a tray insertable inside the mouth, - a plurality of independent cameras arranged on the tray, each camera being equipped with a corresponding fixed focus lens, having a corresponding field of view and being designed to capture a corresponding image of the teeth within the field of view and to transmit the image to the central control unit, each image being composed by a plurality of pixels, and - illumination means arranged on the tray and designed to illuminate the fields of view of the cameras, wherein the central control unit is programmed to estimate the three-dimensional structure of the teeth by estimating independently for each image a depth value for each pixel thereof.

处理2D口内图像并且渲染患者的新颖视图

Resumen de: WO2025188671A1

Systems, apparatuses, and methods disclosed herein are directed to systems, methods, and apparatuses for enabling a patient to capture intra-oral images and for the processing of those images to assist a dentist or orthodontist in evaluating the state of a patient's teeth and the development or progress of a treatment plan.

用于3D打印的装置和方法

Resumen de: GB2638786A

3D printing of solid-dosage-forms. A printhead comprising one of an integrated powder dispenser or an integrated peristaltic pump 11, where the printhead may be interchangeable and may comprise a multi-tip array. A 3D printer comprising one or more of the printheads. The peristaltic pump may comprise a thermostatic peristaltic pump and tubing 13 for pumping at up to 160 °C, a temperature controlled chamber 12 for storing semi-solid material, and may comprise dispensing tips 15 for simultaneous printing of multiple items. 3D printing apparatus comprising the 3D printer and a build platform with integrated capsule holders and/or moulds. 3D printing apparatus comprising a conveyer belt and balance. Methods of manufacturing solid-dosage-forms comprising use of the 3D printer to print semi-solid material at up to 160 °C, fill capsules or moulds, or print multiple items simultaneously.

Automatic in-home senior care system augmented with internet of things technologies

Resumen de: US12758096B1

The in-home care of seniors is augmented using Internet of Things (IOT) technologies. In-home sensors monitor a senior and their caregiver. Physical conditions and psychological conditions may be monitored. In some implementations, a machine learning system has a classifier trained to detect a specified condition, such as depression. The system may perform various transformations of raw sensor data into a format indicative of a particular condition. In one implementation, a psychological or medical condition has symptoms in which each symptom has one or more measurable events. Mappings between symptoms, events, sensor data, and sensor transformation functions may be supported.

피드백 메커니즘을 구비한 해부학적 구조의 생물 물리학적 프로세스를 제어하기 위한 컴퓨터 지원 방법

Resumen de: WO2025176358A1

The invention relates to a computer-assisted method which presents an innovative approach to simulating and visualising the complex effects of positional changes and compressions on organs in the human body and provides feedback in the form of a signal. The aim of the invention is to provide therapeutic users, such as doctors, surgeons, therapists, and medical professionals, with a deeper understanding of physiological processes in the body, in particular with regard to the interactions between different organs under altered physical conditions. In summary, this computer-assisted method offers an advanced means of analysing and visualising the effects of physical changes in the human body, which can be of significant benefit for therapeutic applications. It enables precise planning and prediction of medical interventions, thereby contributing to improved patient care, and primarily serves to provide feedback to the therapist or user.

SOFT TISSUE RECONSTRUCTION IMPLANTS AND FORMING METHOD THEREFOR

Resumen de: US2023146295A1

0000 Embodiments herein relate to an implant for insertion into a patient. The implant comprises a plurality of unit cells arranged to form a three-dimensional lattice structure, the three-dimensional structure comprising a resting volume of the implant. The plurality of unit cells are arranged to form a porous network of the three-dimensional structure, and wherein the three-dimensional structure is a reversibly compressible three-dimensional structure, wherein a bulk porosity of the three-dimensional structure of the implant is at least 50%. Also disclosed is a method of tissue reconstruction or tissue augmentation. The method comprises implanting into the body of a subject an implant of the disclosure.

一种原位梯度双功能3D打印PEEK植入物的制备方法

Resumen de: CN122874653A

本发明公开了一种原位梯度双功能3D打印PEEK植入物制备方法，该方法通过多材料共挤成型方式，将具有骨整合促进作用的生物活性组分与具有抗菌功能的功能组分分别引入PEEK基体打印材料中，并结合梯度结构设计，实现植入物不同区域的功能化调控；该方法避免了传统共混改性过程中对PEEK分子结构及力学性能的不利影响，同时解决了后处理涂层结合强度不足、复杂结构覆盖不均以及功能组分利用率低等问题；通过原位打印形成力学性能区域与生物功能区域相匹配的梯度结构，使植入物兼具骨整合促进和抗菌功能，提高了PEEK植入物的综合服役性能；本发明制备工艺适用于复杂结构医用PEEK植入物的个性化制造。

COLLAGEN BIOMATERIAL DERIVED FROM ABALONE

Resumen de: WO2023023772A1

The present invention is concerned with a manufactured article prepared from a biomaterial comprising isolated and purified type I collagen fibrils derived from abalone and a method of preparing such an article. The manufactured article can be prepared by 3D bioprinting, and therefore the present invention also envisages a novel bioink for a 3D bioprinter comprising an isolated and purified type I collagen fibril and cartridges containing such a bioink. The invention additionally relates to a method of isolating type I collagen fibrils from abalone. The manufactured article is useful in a number of biomedical applications including as an implantable device where it can function as a 3D bioprinted hard or soft tissue scaffold for tissue engineering.

改善されたＳＬＳ ３Ｄ印刷焼結特性を有するポリカプロラクトン

Resumen de: WO2025073518A1

The present invention refers to a compound particle for 3D printing obtained by hot melt extruding 50 to 90 wt.-% at least one polycaprolactone based polymer; 10 to 50 wt.-% of at least one filler; and optionally up to 5 wt.-% of at least one additive into pellets, wherein the total weight of the components is 100 wt.-%, and thereafter milling the pellets to obtain the compound particle. Furthermore, the present invention refers to a composition for 3D printing comprising a) 94 to 99 wt.-% of at least one compound particle according to the present invention; b) 1 to 6 wt.-% of at least one filler; and c) optionally up to 5 wt.-% of at least one additive; wherein the total weight of a) to c) is 100 wt.-%. Moreover, the present invention refers to a 3D printing method comprising the compound particle or the composition according to the present invention, the article obtained by the 3D printing method and its use as a substitute for bones or a scaffold for broken bones.

診断のためのＡＩモデルをトレーニングするための方法およびシステム

Resumen de: WO2025051996A1

A method (S100) of obtaining training data for an existing artificial intelligence, Al, model to process data for diagnostics purposes, the method comprises the steps of: providing (S20) an input dataset comprising of a first set of data including data representative of a sampling device and a second set of data including time domain data representative of a patient sample; and processing (S30) the input dataset to obtain a transformed dataset to provide as training dataset to the existing Al model.

一种针对脑机接口刺激靶点精准定位仿真装置

Resumen de: CN224821352U

0001 本实用新型公开一种针对脑机接口刺激靶点精准定位仿真装置，属于脑机接口调控技术调控侧的时间干涉电刺激技术领域。该装置包括头颅模型，所述头颅模型具有透明头模，所述透明头模上设有电极片，且内部填充有脑组织等效液，所述电极片的输出端设有大脑皮层仿体导通件，所述电极片的输入端设有设备主机，所述头颅模型上设有位于所述透明头模内的探测器和靶点反馈器，所述探测器分别与所述靶点反馈器和所述设备主机电连接。本实用新型适用于患者治疗前对TI刺激方案进行仿真验证，能达到复刻患者头部仿真模型，实现靶点反馈器对干涉焦点的可视化呈现，并提供实验验证，并可实时动态校正，满足临床精准治疗需求的目的。

水回り機器の情報管理システム

Resumen de: JP2026163126A

【課題】利用者にとって使い勝手が良い水回り機器の情報管理システムを提供する。【解決手段】水回り機器の情報管理システムは、トイレ装置、キッチン、洗面、及び浴室の少なくとも何れか１つの水回り機器が設置された水回り空間に設けられたセンサの情報、又はセンサの情報を処理して得られる情報を記憶する記憶手段を有するサーバ装置と、記憶手段に記憶された情報を表示する表示手段を有する情報通信端末と、を備え、サーバ装置は、水回り機器を利用する利用者が有する情報通信端末に関する情報と、水回り機器の利用時における水回り機器の機器利用情報とに基づいて、記憶手段に記憶された情報を情報通信端末に提供することを特徴とする。【選択図】図１

一种基于血糖监测数据的注射装置智能联动控制方法、系统、设备及存储介质

Resumen de: CN122889245A

本发明公开了一种基于血糖监测数据的注射装置智能联动控制方法、系统、设备及存储介质，涉及数据智能控制技术领域，包括获取血糖监测数据和当前状态，对血糖监测数据执行时间对齐、异常跳变识别和数据置信度评估，生成有效血糖序列、数据置信度；训练风险识别模型，通过有效血糖序列提取多时间窗血糖演化特征；将多时间窗血糖演化特征、数据置信度和当前状态输入风险识别模型，输出分层联动控制策略；通过分层联动控制策略执行联动控制。本发明所述方法在数据处理可靠性、风险层级输出连续性以及控制流程衔接性方面都取得更加良好的效果。

义齿打印实时缺陷检测动态补偿方法

Resumen de: CN122876653A

本申请提供义齿打印实时缺陷检测动态补偿方法，涉及义齿打印的技术领域，包括获取预设的当前层目标切片在预设采样时刻的第一平行偏振图像和第一交叉偏振图像；对第一平行偏振图像和第一交叉偏振图像进行分析，以确定曝光许可结果；对当前层目标切片和曝光许可结果进行分析，以确定义齿补偿操作；根据义齿补偿操作控制预设的义齿打印设备对义齿打印过程进行动态补偿。本申请具有保证提高义齿打印缺陷动态补偿的准确性的效果。

一种支抗钉定位导向装置及制作方法及使用方法

Resumen de: CN122874153A

本发明涉及一种支抗钉定位导向装置及制作方法及使用方法；包括基板，所述基板上开设有支抗钉导向通孔，基板内侧面与目标植入区域及相邻的两颗牙齿的外侧面相互贴合，支抗钉导向通孔的深度与择取的支抗钉长度相等，支抗钉导向通孔内径不小于择取的支抗钉钉头外径；实现对‌骨内植入深度的个体化、量化精确控制‌，降低过深损伤结构或过浅不稳定等相关风险。

一种基于悬浮生物3D打印的多层骨软骨支架及其制备方法

Resumen de: CN122874654A

本发明公开了一种基于悬浮生物3D打印的多层骨软骨支架及其制备方法，属于生物医用材料技术领域，该多层骨软骨支架包括软骨层、钙化软骨层和软骨下骨层，利用悬浮3D打印技术制备得到，制备软骨层墨水、钙化软骨层墨水和软骨下骨层墨水；软骨层墨水包括基底成分、软骨细胞和聚凝胺；钙化软骨层墨水包括基底成分和成纤维细胞生长因子；软骨下骨层墨水包括基底成分、纳米羟基磷灰石、骨髓间充质干细胞或成骨细胞和骨形态发生蛋白；依次在悬浮支撑浴中进行软骨下骨层墨水、钙化软骨层墨水和软骨层墨水的打印，光固化后即可得到多层骨软骨支架。该多层骨软骨支架生物相容性好、避免了层间连接不紧密的问题。

錠剤印刷装置、錠剤印刷方法および錠剤検査装置

Resumen de: JP2026163520A

0001 【課題】錠剤の検出を良好に行なうことができる錠剤印刷装置、錠剤印刷方法および錠剤検査装置を提供する。 【解決手段】実施形態に係る錠剤印刷装置１は、制御装置が、第１の主撮像装置で撮像される前の錠剤の表裏のいずれかの面を撮像する、照明部を備えた先行撮像装置の撮像画像に基づいて錠剤において撮像された面が表裏のどちらの面であるかを判別し、この判別結果に基づいて、当該錠剤を撮像する際の第１の主撮像装置および第２の主撮像装置の照明部の照明条件を切り替える。 【選択図】図１

一种兽用长效缓释植入式给药装置的精密制造方法

Resumen de: CN122874182A

本发明涉及给药装置技术领域，尤其涉及一种兽用长效缓释植入式给药装置的精密制造方法，该方法首先获取对应治疗场景的多阶段梯度释药需求谱；进而构造反映释药动力学特性的梯度孔隙率特征，并筛选匹配的可降解材料降解区间；同步分析药物扩散速率梯度与材料降解波动，识别由界面粘附及不均匀降解导致的释药偏差区域；建立偏差区域、孔隙连通性变化速率与药物释放动力学模型的映射关系，量化评估腔体结构参数与释药要求的匹配度；最终基于评估结果生成精密加工参数以完成制造。本发明实现了从临床需求到制造参数的精准闭环，有效解决了传统工艺中释药速率偏离预期及批次一致性差的问题，显著提升了微柱的释药稳定性与治疗安全性。

一种术后3D打印瘢痕器及其制备方法

Resumen de: CN122874236A

本发明涉及医疗辅助器具技术领域，具体为一种术后3D打印瘢痕器及其制备方法，旨在解决耳部瘢痕治疗中压力施加不均、不适应个体解剖等现有问题。瘢痕器由医用级光敏树脂支撑，是基于患者患耳三维模型数据定制而成，由三个零部件组成且边缘设有带螺丝的贯穿孔，瘢痕器可以调节对耳部的压力并实现压力均匀分布，瘢痕器制作时先扫描患者耳部获得高精度数据，随后进行三维数据重建，然后3D打印，最后抛光固化消毒处理完成。本瘢痕器能精准复刻患者的耳廓结构，还可以根据瘢痕恢复情况调整压力或重新定制；本发明佩戴舒适美观，能够有效控制耳部瘢痕术后增生，提升患者治疗依从性，还能够提升瘢痕疙瘩治疗的精准性、舒适性和疗效。

錠剤印刷装置及び錠剤印刷方法

Nº publicación: JP2026163110A 09/10/2026

Solicitante:

芝浦メカトロニクス株式会社

Resumen de: JP2026163110A

【課題】錠剤に形状及び配置の少なくともいずれかにおいて不規則な模様がある場合でも、錠剤の外観又は印刷における異常を適切に検出できるようにする。【解決手段】錠剤印刷装置１０００は、搬送機構２０により搬送される、大きさ、形状及び配置の少なくともいずれかにおいて不規則な模様が外面にある錠剤Ｔに印刷する印刷部５０と、印刷部５０による印刷の前段階及び後段階の少なくともいずれかで錠剤を撮像する撮像部（第１の撮像部４０、第２の撮像部６０）と、撮像部と搬送機構２０との間に配置される、模様の色に対応させた光学フィルタ部（第１の光学フィルタ部７１、第２の光学フィルタ部７２）とを備える。【選択図】図１