Bioimpresión 3D

NOVEL FIBRINOGEN-BASED BIOINKS FOR WOUND HEALING AND TISSUE REGENERATION

Resumen de: EP4631538A1

The present invention relates to a bioink formulation comprising fibrinogen and a glycosaminoglycans (GAGs)/collagen (Col) matrix, preferably comprising human cells, preferably human mesenchymal stem cells (hMSCs), keratinocytes and/or human dermal fibroblasts (hDFs), and its use in the treatment of tissue or bone injuries or damages, specifically skin tissue injuries or damages.

3D FAT TISSUE STRUCTURE, PRODUCED USING LIGHT-BASED STRUCTURING CURING, FOR USE AS A BREAST IMPLANT

Resumen de: CN120322257A

The present invention relates to a 3D adipose tissue scaffold for use as a breast implant for surgical, therapeutic, prophylactic or aesthetic recovery, construction or replacement of human breast tissue, in which the 3D adipose tissue scaffold has a matrix consisting of a biocompatible polymer, the matrix being colonized with a plurality of biological cell types, wherein the colonization of the plurality of cell types is carried out during the formation of a matrix made of a biocompatible polymer, accompanying the formation of a network of vascular structures within the 3D adipose tissue scaffold. Light-based structured curing of a photo-polymerizable or photo-crosslinkable liquid is used to build a matrix composed of a biocompatible polymer. The invention also relates to the use of a 3D adipose tissue scaffold as a human breast implant, the 3D adipose tissue scaffold having a matrix consisting of a biocompatible polymer, the matrix being colonized with a plurality of cell types, the colonization of the plurality of cell types being carried out in the process of forming the matrix consisting of a biocompatible polymer, the present invention relates to a 3D adipose tissue scaffold, in which a network of vascular structures is formed within the 3D adipose tissue scaffold, characterized in that a matrix consisting of a biocompatible polymer is constructed by means of light-based structured curing of a photopolymerizable or photocrosslinkable liquid.

Patient-specific humeral head guide device and systems and method for manufacturing same

Resumen de: GB2640326A

A patient-specific humeral head guide device may be designed and manufactured to contour the shape of a patient’s humeral head from medical images. A humeral shaft is identified and two or more points along the shaft used to define a humeral axis along with a colinear point based on a centre of lesser tuberosity. A humeral sagittal plane is identified, as is a coplanar anterior axis. A resection plane is also identified based on the sagittal plane and an angle of inclination from the longitudinal axis. Computer aided manufacturing (CAM) printing instructions are generated to print a resection channel for a cutting device. The humeral head contouring body may be of loop style and may have an extended footprint to contour a portion of lesser tuberosity. There may be fixation wire channels, at least one of which permits visual confirmation that a patient forearm aligns with an anterior axis. There may be a channel for receiving an intermedullary reamer aligned to a humeral canal centre. The CAM instructions may include G-code that causes a three-dimensional (3D) printer to manufacture a patient-specific humeral head guide device and for other various portions of the device.

SYSTEM FOR EDGE CASE PATHOLOGY IDENTIFICATION AND IMPLANT MANUFACTURING

Resumen de: WO2024151669A1

Systems and methods for identifying edge case pathologies for inspection in a patient-specific orthopedic implant procedure are disclosed. A system can analyze patient data, such as implant data, pre-operative data, post-operative data, or implant manufactured data to identify edge case pathologies in the patient data that can affect installing an implant in the patient. Based on the type of edge case pathology, the system sends a notification for a human, such as a healthcare provider, to review the patient data prior to installing the patient-specific orthopedic implant in the patient.

一种牙齿3D打印机用可调式操作平台

Resumen de: CN223431997U

本实用新型涉及3D打印设备技术领域，提供了一种牙齿3D打印机用可调式操作平台，包括：安装板，驱动电机，通过架体设置在所述安装板的表面上；还包括：两个槽口，开设在所述安装板表面的对称处，其中一个所述槽口的内部设置有螺纹杆一，所述螺纹杆一的一端设置在驱动电机的输出端表面上。本实用新型，通过旋转滑槽内部的螺纹杆二，带动滑块在滑槽的内部进行移动，使得连接板表面的安装架进行横向移动，带动放置板对准打印机本体，通过驱动电机工作，带动输出端螺纹杆一表面的U型架沿着导向杆进行横向移动，使得打印的牙齿对准打印机本体的输出端，配合电动推杆工作，带动移动板表面的安装座进行纵向移动，完成打印机本体的打印工作。

三维自组装支架

Resumen de: US2025313799A1

A three-dimensional scaffold includes a plurality of scaffold elements. Each scaffold element includes at least one peptide component, which comprises a stretch of amino acids, and at least two nucleic acid components. The at least two nucleic acid components of the plurality of scaffold elements are configured to mediate self-assembly of the three-dimensional scaffold.

假肢打印方法、装置、电子设备、存储介质及计算机程序产品

Resumen de: CN120770988A

本申请公开了一种假肢打印方法、装置、电子设备、存储介质及计算机程序产品，其中，方法包括：获取第一用户的第一生理数据组；调用第一人工智能模型对第一生理数据组进行处理，得到第一约束参数组；第一人工智能模型用于基于输入的生理数据组推荐约束参数组；约束参数组表征该输入的生理数据组对应的机械性能要求相关的约束；以第一约束参数组作为约束，调用生成式设计算法对第一生理数据组进行处理，得到第一设计参数组；生成式设计算法用于基于输入的生理数据组生成满足对应的舒适度要求的设计参数组，且设计参数组中包含假肢的多个设计参数；基于第一设计参数组与切片参数组，生成第一文件，并输出第一文件至三维打印装置。

原位润滑3D打印Janus骨软骨修复支架及其制备方法

Resumen de: CN120771351A

本发明涉及一种原位润滑3D打印Janus骨软骨修复支架及其制备方法，其中，所述支架由3D打印制得，包括软骨下骨层及软骨层，其中：所述软骨下骨层由GelMA和NAGA负载nHA制得，以促进骨愈合；所述软骨层配置两性离子单体，实现原位润滑。本发明可通过软骨层支架结构润滑改性实现原位润滑，通过软骨下骨层支架负载羟基磷灰石促进骨愈合。

用于制备再生型植入体的激光增材制造系统

Resumen de: CN120772553A

本发明提供用于制备再生型植入体的激光增材制造系统，属于激光增材制备技术领域。该系统包括精细动态聚焦模块、成形模块、烟尘净化模块和风场调控模块；精细动态聚焦模块包括：光学聚焦单元，包括同轴设置的激光器、变倍扩束镜和振镜组件及场镜；水冷单元，其位于变倍扩束镜与振镜组件之间，包括水冷遮光孔板与外设的冷水机；动态变焦单元，通过驱动场镜位移形成混合变焦系统实现动态变焦；成形模块包括：成形缸；粉末床；加热器阵列，安装于成形缸内部侧壁与顶部并环绕粉末床的加热器阵列；温度传感器阵列，分布于粉末床上；风场调控模块在成形缸内部形成高温强迫环流。本发明解决了现有技术中再生型植入体激光增材制造的精细微孔制备难题。

一种丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石及其制备方法和应用

Resumen de: CN120771340A

本发明公开了一种丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石(HAP@AM)及其制备方法和应用，涉及骨修复支架材料技术领域，所述丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石为表面接枝有甲基丙烯酰胺化阿仑膦酸钠的纳米羟基磷灰石；丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石中甲基丙烯酰胺化阿仑膦酸钠的接枝率为1～5wt％，丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石的平均粒径为200～800nm，Zeta电位为‑12～‑22mV。本发明制备的HAP@AM在GelMA中具有优异的分散性与稳定性，与GelMA制成3D打印墨水，还具有优异的打印性能和力学性能。

一种运用3D打印技术制作可降解的乳房植入物的方法

Resumen de: CN120756090A

本申请提供了一种运用3D打印技术制作可降解的乳房植入物的方法，包括以下步骤：在3D打印喷头的加热腔内灌注打印材料；对加热腔加热至温度到达预设温度时3D打印设备开始打印工作，包括打印喷头的喷嘴挤出打印材料，并按预设程序在打印平台上方移动，保持加热腔温度稳定在预设温度；预设程序包括打印路径以预设图形的中心为起点，沿径向从内向外逐层打印，完成预设图形最后一层时打印工作结束；停止对加热腔的加热。通过加热腔稳定持续的加热，材料分子量逐渐减小，结合3D打印方法自预设图形由内向外逐层打印，使得乳房植入物的分子量自中心向外层逐层减小，解决了现有手段制作的乳房植入物的降解方向与细胞再生进程无法动态协同的问题。

一种仿生灯笼框架复合内固定装置及制备方法

Resumen de: CN120753772A

本发明公开了一种仿生灯笼框架复合内固定装置及制备方法，涉及骨科医疗器械技术领域，包括植入体和多棒桥接结构，多棒桥接结构由多个纵向连接棒与横向锁定钉组成，植入体由多个多层级仿生结构组成，多层级仿生结构包括两个对称设置的六边形上下层结构以及设置在两个六边形上下层结构之间的中间螺旋层结构。本发明从蜂窝与耗牛角宏微观结构中受到启发，采用耦合仿生技术制备出的多层级仿生结构具有优异的力学性能，缓冲吸振能力强，可有效匹配天然骨力学性能，可有效避免患者植入后二次损伤和“应力屏蔽”效应，通过电化学沉积方法引入的复合涂层弥补了单一植入体结构生物相容性不足、抗菌性不足、成骨分化能力弱的问题。

功能化丝素蛋白基生物墨水、仿生软骨水凝胶及其制法

Resumen de: CN120754319A

本发明属于生物材料与组织工程技术领域，涉及一种功能化丝素蛋白基生物墨水、仿生软骨水凝胶及其制法。该墨水含有引发剂、SFMA、GelMA、PEGDA和OBC，各组分的配比严格控制；将该墨水与干细胞混合均匀后，引发固化交联反应，制成多重仿生软骨水凝胶。该水凝胶包括多重网络结构水凝胶以及同时分散在多重网络结构水凝胶中的OBC及干细胞，具有和真实软骨组织匹配的压缩模量以及多孔结构。本发明提供的功能化丝素蛋白基生物墨水及多重仿生软骨水凝胶，解决了现有技术中供体不足、免疫排斥、仿生维度单一、力学性能不匹配等问题，能实现高精度打印并高效促进软骨再生。

一种距下关节固定装置

Resumen de: CN223416347U

本实用新型提供了一种距下关节固定装置，属于医疗器械技术领域。该距下关节固定装置包括足托，足托套设在穿戴者的足跟部；足托包括底板以及设置在底板两侧顶端的第一侧板与第二侧板，第一侧板与第二侧板相对向内折弯，第一侧板与第二侧板顶端分别向底板方向凹陷形成有凹槽；第一侧板与第二侧板与穿戴者的脚踝相贴合。该距下关节固定装置结构简单，适应性好，能充分开放前足活动空间，减少穿戴不适感，达到用户自我锻炼重塑肌肉韧带及行走发力问题，安全性高。

SYSTEMS AND METHODS FOR OPTIMIZED PATIENT SPECIFIC TISSUE ENGINEERING VASCULAR GRAFTS

Resumen de: US2025009937A1

It has been established that optimizing cell seeding onto tissue engineering vascular grafts (TEVG) is associated with reduced inflammatory responses and reduced post-operative stenosis of TEVG. Cell seeding increased TEVG patency in a dose dependent manner, and TEVG patency improved when more cells were seeded, however duration of incubation time showed minimal effect on TEVG patency. Methods of engineering patient specific TEVG including optimal numbers of cells to maintain graft patency and reduce post-operative stenosis are provided. Closed, single-use customizable systems for seeding TEVG are also provided. Preferably the systems are custom-designed based on morphology of the patient specific graft, to enhance the efficacy of cell seeding.

METHOD FOR PRODUCING A DENTAL RESTORATION

Resumen de: KR20240080147A

The present invention relates to a method for manufacturing a dental restoration, comprising the steps of: (s101) determining a first space area of a dental restoration subject to a higher load than a second space area of the dental restoration; and (s102) manufacturing the dental restoration in the first space area with a different manufacturing material from the second space area.

一种带有螺硫吡喃基团的聚氨酯丙烯酸酯及其合成方法和应用

Resumen de: CN120757748A

本发明提供了一种带有螺硫吡喃基团的聚氨酯丙烯酸酯及其合成方法和应用，涉及义齿基托材料技术领域。带有螺硫吡喃基团的聚氨酯丙烯酸酯中将螺硫吡喃的C‑S弱共价键引入聚氨酯丙烯酸酯主链中，利用其在外力作用下易发生均裂的特性来耗散能量，并通过自由基介导的点击反应实现链间交联，从而增强机械强度，使其适用于义齿基托、口腔修复体、生物医学植入物等领域。

SERIES OF DEVICES FOR PREPARING THE DISPLACEMENT, IN PARTICULAR A PERMANENT DISPLACEMENT, OF THE OCCLUSAL PLANE OF A PERSON, AND ASSOCIATED METHODS

Resumen de: US2025312125A1

A series (100) of devices for assisting in the displacement of the chewing plane of a person (P) is explained, comprisingat least two devices (10),wherein the devices (10) each comprise at least one jaw device (11, 12),wherein the at least one jaw device (11, 12) comprises an upper jaw device (11) and/or a lower jaw device (12),and wherein the devices (10) are designed to be worn by the person (P) according to a predetermined sequence.In at least one device (10.1, 10.2), the at least one jaw device (11, 12) comprises at least one height element on a first side. At least two contact areas, preferably local contact areas, are formed on the at least one height element at mutually different positions of molar elements. At least one further contact area is formed on a second side of the at least one jaw device (11, 12), in particular a further local contact area. The at least three contact areas define the plane (GE),wherein the plane (GE) deviates from a starting chewing plane of the person (P) or from a current chewing plane of the person (P) with respect to its inclination changed by the at least one height element in a frontal section or sagittal section and/or deviates with respect to its height position changed by the at least one height element, andwherein in at least one other device of the series (100) a different inclination in a frontal section or sagittal section and/or a different height position of the respective plane is adjusted by at least one further height eleme

COMPACT ENDOSCOPE DESIGN FOR THREE-DIMENSIONAL SURGICAL GUIDANCE

Resumen de: US2025311915A1

The present invention is directed to endoscopic structure illumination to provide simple, inexpensive 3D endoscopic technique to conduct high resolution 3D imagery for use in surgical guidance system. The present invention is directed to an FPP endoscopic imaging setup which provides a wide field of view (FOV) that addresses a quantitative depth information and can be integrated with commercially available endoscopes to provide tissue profilometry. Furthermore, by adapting a flexible camera calibration method for the 3D reconstruction technique in free space, the present invention provides an optimal fringe pattern for the inner tissue profile capturing within the endoscopic view and validate the method using both static and dynamic samples that exhibits a depth of field (DOF) of approximately 20 mm and a relative accuracy of 0.1% using a customized printed calibration board. The presented designs enable flexibility in controlling the deviated angle necessary for single scope integration using FPP method.

AUTOMATED METHODS FOR DESIGNING AND FABRICATING AN INTRA-ORAL APPLIANCE

Resumen de: US2025312122A1

A method for designing a custom-made intra-oral appliance includes obtaining a virtual 3D reconstruction of an oral cavity, identifying an appliance region, obtaining a 3D appliance mesh from the appliance region, and processing the 3D appliance mesh for obtaining a volumetric appliance mesh. A method for obtaining a virtual 3D reconstruction of an oral cavity, the virtual 3D reconstruction being suitable for use in designing custom-made intra-oral appliances, and a method for designing an intra-oral appliance. The method for obtaining a virtual 3D reconstruction of an oral cavity includes obtaining at least one 2D image of an oral cavity, wherein the at least one image is acquired by a consumer electronics product, transforming the obtained at least one 2D image into an initial virtual 3D reconstruction of the oral cavity, and transferring information included in a further virtual 3D reconstruction to the initial virtual 3D reconstruction.

DENTAL IMPLANTS

Resumen de: US2025312130A1

The present teachings relate to an assembled dental implant comprising a metallic body manufactured at least partially via an additive manufacturing process: wherein the body is provided with a cavity having an opening on one end of the body. and an inlay part at least partly introduced within the cavity and scalably connected with the metallic body thereby sealing-off the cavity. The present teachings also relate to the metallic dental implant body and manufacturing methods.

PATIENT-SPECIFIC HUMERAL HEAD GUIDE DEVICE AND SYSTEMS AND METHODS FOR MANUFACTURING SAME

Resumen de: US2025312048A1

A patient-specific humeral head guide device may be designed and manufactured to contour the shape of the humeral head of the patient, as determined from the medical images. For example, a system may generate computer-assisted manufacturing (CAM) instructions based on one or more medical images of the shoulder of the patient. The CAM instructions may include G-code that causes a three-dimensional (3D) printer to manufacture a patient-specific humeral head guide device. The system may generate G-code for other various portions of the patient-specific humeral head guide device. For example, the system may generate instructions for manufacturing a patient-specific humeral head guide device to include a footprint (including a body and an extended footprint) that contours the humeral head, a plurality of fixation wire channels (for drilling to receive a respective fixation wire), a reaming channel, a resection channel (for cutting), and/or other portions described herein.

COMPOSITE POSITIVE AND NEGATIVE POISSON’S RATIO TISSUE ADHESIVES

Resumen de: US2025312511A1

Some tissue adhesives include a solid having bio-absorbable fibers and at least one of nano-spheres, micro-spheres, nano-tubules, or micro-tubules. A first layer of the solid has a positive Poisson's ratio and a second layer of the solid has a negative Poisson's ratio. In some cases, the second layer has been transformed from a positive Poisson's ratio material to a negative Poisson's ratio material. In some cases, an entire face of the first layer is in contact with an entire face of the second layer. In some cases, the second layer includes one or more pores, at least a portion of the one or more pores containing a secretion from one or more barnacles. In some cases, the secretion is configured to adhere the tissue adhesive to one or more layers of tissue to at least partially close a wound.

METHOD FOR MANUFACTURING POLYMER-BASED MICRONEEDLE PATCH AND MICRONEEDLE PATCH MANUFACTURED THEREBY

Resumen de: US2025312584A1

The present invention relates to a method for manufacturing a polymer-based microneedle patch designed to maximize skin penetration performance. The polymer-based microneedle patch of the present disclosure can be manufactured to have enhanced penetration power and flexibility as microneedles formed of a polymer with both rigidity and flexibility are combined with an elastic and breathable substrate.

MEDICATION TRACKING

Nº publicación: US2025316367A1 09/10/2025

Solicitante:

BLUESIGHT INC [US]
Bluesight, Inc

Resumen de: US2025316367A1

A system and method is described for printing a label with an RFID tag. The system includes an RFID reader that queries a first RFID tag coupled to a first medicinal container that includes a medication. In response, the system receives a first unique identifier and uses the first unique identifier to determine a status of the medication, associate the first medicinal container with a medical provider and print a second label that includes a second RFID tag for a second medicinal container.