Resumen de: US2025129138A1
The present application provides a preparation method for biosynthesis of a human body structural material. A polypeptide has the amino acid sequence of SEQ ID NO. 4, 5 or 6. Recombinant type-VII humanized collagen prepared in the present application has high activity of promoting cell proliferation and does not produce an immune response when applied to a human body, and the preparation method therefor is novel and can obtain the recombinant type-VII humanized collagen on a large scale, and is widely applied in the preparation of human body structural materials.
Resumen de: US2024374359A1
A computer-implemented method for generating a color 3D model for a dental restoration. The method receives color information, a color distribution map. and shape for a tooth. The color information is assigned to the color distribution map. The color information and the color distribution map are then combined with the shape to generate a digital color 3D model. The resulting 3D model includes volumes for different color materials for the restoration to provide for color transition zones, which can be 3D printed from the 3D model to made a corresponding restoration.
Resumen de: CN119654116A
The present invention relates to a step (S01) for generating and storing, by a computer, a plurality of tooth images that are provided so as to be moved step by step in the order of orthodontic stages, a step (S02) for displaying any one of the plurality of tooth images, in which in the tooth images displayed in step S02, in order to determine the overall shape of a transparent orthodontic appliance, first a transverse reference line is provided for each tooth, and then a transverse reference line is provided for each tooth. S03, displaying the reference line, setting a cutting line of the orthodontic appliance in the tooth image displayed in the step S02 and displaying the cutting line, and displaying the semitransparent state of the transparent orthodontic appliance covering the upper tooth and the lower tooth according to the cutting line set in the step S04, and displaying the transparent orthodontic appliance according to the semitransparent state of the transparent orthodontic appliance covering the upper tooth and the lower tooth. And a step (S05) of displaying the first treatment image.
Resumen de: CN120485595A
本申请涉及金属材料增材制造技术领域,尤其涉及一种通过纳米铁粉均匀掺杂抑制β‑fleck缺陷的钛合金及其制备方法与应用。提供的钛合金材料以微米球形钛粉为基材,基材的内部均匀分布纳米铁粉;其中,以钛合金材料的总质量为100%计,纳米铁粉为0.5‑2.0wt%、微米球形钛粉为98~99.5wt%。由于纳米铁粉尺寸小、比表面积大,在激光粉末床熔融过程中快速溶解并均匀扩散至钛基体,避免了微米铁粉因扩散不充分导致的局部铁元素偏析的问题,同时纳米铁粉扩散速度快,并且避免了局部铁富集,确保无出现β相富集区(β‑fleck)和脆性TiFe析出相,有利于钛合金材料的广泛应用。
Resumen de: CN120478721A
本发明涉及生物医用材料技术领域,公开了一种改性聚己内酯支架及其制备方法和应用。所述改性聚己内酯支架包括由以下原料制备得到:聚己内酯、羟基磷灰石、纳米粘土和溶剂;其中,所述纳米粘土选自蒙脱石、层状双氢氧化物、凹凸棒石、海泡石、高岭土和合成型纳米粘土中的至少一种。本发明提供的改性聚己内酯支架,基于羟基磷灰石和纳米粘土的协同作用,实现了力学性能、生物活性和免疫调控功能的协同优化,支架具有接近松质骨的抗压强度,通过多级孔道结构和亲水性表面显著促进细胞粘附与迁移,羟基磷灰石与纳米粘土的协同作用不仅诱导干细胞成骨分化,还调控巨噬细胞向促修复的M2型极化,创造了利于骨再生的微环境。
Resumen de: EP4454601A2
The invention relates to a custom tool for forming a dental restoration in a mouth of a patient including an occlusal plane. The custom tool comprising a facial mold body for a patient-specific, customized fit with the facial side of at least one tooth of the patient, wherein the facial mold body includes a restorative portion and a first engagement portion extending away from the restorative portion, a lingual mold body for a patient-specific, customized fit with the lingual side of the tooth of the patient, wherein the lingual mold body includes a restorative portion and a first engagement portion extending away from the restorative portion. The first engagement portion of the facial mold body interlocks with the first engagement portion of the lingual mold body. The facial mold body and lingual mold body are configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of at least one tooth to be restored. The first engagement portion of the facial mold body and the first engagement portion of the lingual mold body extend generally perpendicular to the occlusal plane, and wherein either (i) the first engagement portions are sized and shaped to be adjacent the posterior teeth of the patient, and the restorative portions are sized and shaped to mate with the anterior teeth; or (ii) the first engagement portions are sized and shaped to be adjacent the anterior teeth of the patient, and the restorative portions are sized and sha
Resumen de: US2024099816A1
Methods and systems are provided for diagnosing and generating a treatment plan for temporomandibular joint dysfunction where a polymeric shell appliance is utilized to generate one or more activation forces that facilitate tooth movement. The polymeric shell appliances may comprise one or more tooth receiving cavities, in which each of the plurality of tooth receiving cavities is shaped and arranged to provide a counter moment of each of the plurality of teeth.
Resumen de: CN120484471A
本发明属于生物医用材料技术领域,提供了一种聚L‑丙交酯‑己内酯复合材料及其制备方法和应用、血管支架。本发明的复合材料以聚L‑丙交酯‑己内酯(PLCL)和金属氧化物(三氧化二铁、氧化镁、氧化锌和二氧化钛中的一种或多种)为制备原料。相比PLLA,本发明的复合材料具有更好的强度和韧性;金属氧化物可以提高聚合物PLCL的降解速度。所以,本发明的复合材料兼具优异的韧性、强度和降解速度。进一步地,尤其是当金属氧化物为三氧化二铁时,所得复合材料的断裂伸长率和拉伸强度都有显著提升;且体外降解速率也有显著提升;同时,具有优异的生物相容性。
Resumen de: CN120478739A
本发明公开了一种可体温回复的形状记忆血管支架及制备方法,其制备方法包括:将聚乳酸粒料烘干后,加入PEG增韧,熔融共混,再加入聚乳酸纤维作为增强相,螺杆挤出得到复合材料,该材料相对于纯聚乳酸材料而言,提高了形状记忆材料的韧性,降低了形状记忆材料的形状回复温度,实现“人体体温”下形状回复。通过3D打印制备血管支架,本发明制得的形状记忆血管支架具有较好的回复率、固定率、更低的回复温度以及良好的生物相容性。
Resumen de: CN120478726A
本发明涉及材料制备技术领域,特别涉及一种用于3D打印构建组织工程皮肤的复合生物墨水及其制备方法和应用,复合生物墨水包括氧化海藻酸钠‑明胶生物墨水和AgNPs胶体溶液,氧化海藻酸钠‑明胶生物墨水通过氧化海藻酸钠与明胶构成席夫碱网络完成凝胶化。通过聚多巴胺原位还原#imgabs0#溶液,得到AgNPs胶体溶液。本发明提供的复合生物墨水具有良好的可打印性、机械性能,可用于3D生物打印;不仅拥有优秀的生物相容性还兼具自愈、抗菌、促进皮肤成纤维细胞增殖、分化的功能,可用于组织工程皮肤支架的制备,促进皮肤组织伤口愈合与功能重建,有较高的应用前景。
Resumen de: CN120478195A
本发明公开一种微藻光合治疗水凝胶面膜及其制备方法,利用悬浮浴3D打印技术与面部扫描技术,使用微藻生物墨水定制化生产3D贴合的面膜,使之在使用过程中利用光合作用产生氧气并释放有效成分,起到产氧消炎、促进细胞迁移和清除自由基来促进皮肤修复的作用,在二次交联的过程中引入小分子胶原和Se元素,促进细胞增殖与迁移,起着支撑、修复、保护的三重抗衰老作用。本发明可持续和环境友好,配方简单、设计科学,直接利用微藻、以可再生、可降解材料为原料,制备和使用过程无污染排放,原料可回收,与传统的面膜制备方式相比更加低碳环保。
Resumen de: WO2025166443A1
One aspect described herein is a method of 3D printing a tissue model in a contained volume of photocrosslinkable bioink located on a print surface. The bioink may contain living cells. The method may comprise maintaining, with the print surface, a cell viability temperature of the contained volume; locating an objective lens vertically in a bottom working plane within the contained volume and successive working planes located above the bottom working plane by moving the lens vertically relative to the surface; and in the bottom working plane and each successive working plane, moving the voxel horizontally by directing the laser beam into the objective lens at different angles at different times; focusing, with the objective lens, at each different angle and time, the laser beam into a voxel; polymerizing, with the voxel, a portion of the contained volume at each horizontal location; and moving the contained volume horizontally.
Resumen de: US2025257011A1
The invention relates to a set of chemicals for the production of a ceramic dispersion or a ceramic gel, a process for the production of a ceramic molded part and a ceramic molded part produced by this process.
Resumen de: US2025256078A1
This disclosure generally relates to devices for printing a graft onto a wound. In some embodiments, the devices comprise one or more reservoirs adapted to receive and/or contain a biological material or a synthetic material. The devices may further comprise a cooling component adjacent the reservoir configured to cool the internal portion of the one or more reservoirs at greater than or equal to −30° C. and less than or equal to 10° C., according to other embodiments. In some embodiments, the device comprises a dispenser configured to dispense the biological and/or synthetic material onto a surface of the wound. In some embodiments, the device preserves the native structure of the biological and/or synthetic material after deposition. This disclosure also provides methods for printing a graft onto a wound e.g., using the devices contemplated herein.
Resumen de: US2025256248A1
An apparatus may be for producing nanocarriers and/or nanoformulations. A process may be for producing a nanocarrier and/or a nanoformulation with this apparatus. According to the preparation, a first liquid phase and a second liquid phase are mixed first to give a primary mixture using a static mixer. In a subsequence mixing step the primary mixture is diluted with a third liquid. An aspect of apparatus may be that the arrangement of the static mixer inside a linear pipe conducting a third liquid phase. Thus, the primary mixture exiting the mixer is instantaneously diluted with to give secondary mixture. The volume flow of the third mixture is chosen larger than the volume flow of the primary mixture. By these measures, nanocarriers with improved morphology and homogeneity are produced. Encapsulation efficiency was enhanced as well.
Resumen de: AU2024221303A1
A method and apparatus enabling additive manufacturing of individualized oral therapeutic capsule forms containing multiple medicinal ingredients, also referred to as a personalized polypill process. A process and supporting apparatus to fulfil the formulated therapy prescribed by a physician to address the medical conditions of an individual patient, furthering the practice of personalized medicine. The methods and apparatus apply to the powder forms of active pharmaceuticals, dietary supplements, and specialized chemicals, such as diagnostic inks and dyes. The methods teach the deposition of computer-controlled amounts of high-potency powder forms of active ingredients deposited in sequential layers into a single delivery form. Each active ingredient layer is sequentially deposited to a programmable dosage accurately controlled with closed-loop gravimetric sensing, enabling sub-milligram mass deposition accuracy. Cumulative doses are compacted into segregated layers of programmable density with the optional addition of an inert barrier film between each chemical entity to minimize interactions.
Resumen de: US2025255737A1
A prosthetic assembly includes a socket and a liner. The socket includes a first interlocking feature and defines an inner volume. The liner includes a second interlocking feature. The first interlocking feature and the second interlocking feature are configured to engage each other when the liner is inserted into the inner volume of the socket. The liner is configured to receive a distal limb of a patient. At least one of the socket or the liner include inner voids extending within walls of the socket or the liner.
Resumen de: US2025255781A1
This invention relates to methods of producing 3-D printed pharmaceutical products.
Resumen de: US2025258479A1
Methods, systems, and apparatuses are described for guiding placement of transducer arrays on a patient.
Resumen de: WO2025168626A1
The invention relates to a device for producing three-dimensional screen-printed workpieces, in particular a 3D screen-printing system, comprising a printing device having a printing screen for producing at least one screen-printed workpiece layer by layer in a plurality of printing processes and comprising a metering device (18) for metering a pasty printing compound onto the printing screen, wherein the metering device has at least one container (20) for storing the pasty printing compound, a dispensing device (24) for dispensing the printing compound onto the printing screen, and a supply line (26) extending between the container and the dispensing device and supplying the printing compound from the container to the dispensing device.
Resumen de: US2025256194A1
The invention relates to a multi-step method with a number of processes and sub-processes that interact to allow for the selection, design and/or manufacture of a protective sports helmet for a specific player, or a recreational sports helmet for a specific person wearing the helmet. Once the desired protective sports helmet or recreational sports helmet is selected, information is collected from the individual player or wearer regarding the shape of his/her head and information about the impacts he/she has received while participating in the sport or activity. The collected information is processed to develop a bespoke energy attenuation assembly for use in the protective helmet. The energy attenuation assembly includes at least one energy attenuation member with a unique structural makeup and/or chemical composition. The energy attenuation assembly is purposely engineered to improve comfort and fit, as well as how the helmet responds when an impact or series of impacts are received by the helmet.
Resumen de: US2020015573A1
The present invention relates to a system (1) for applying at least two kinds of liquid onto respective targeted areas of a substrate (S). The system (1) includes first and second storage unit (10a, 10b) that accommodate first and second liquids (F1, F2); a pressured gas supply unit (20) that is fluidly connected to the first and second storage unit (10a, 10b); first and second applicator (30a, 30b) that are fluidly connected to the first and second storage unit (10a, 10b); and a controller (40) that is operatively connected to the applicator (30a, 30b). The pressured gas supply unit (20) causes pressure of a pressured gas to act on the liquids (F1, F2) within the storage unit (10a, 10b). The first and second applicator (30a, 30b) each include at least one nozzle (300a, 300b) disposed so as to face the substrate (S). The first and second applicator (30a, 30b) spray the first and second liquids (F1, F2) within the first and second storage unit (10a, 10b) from the nozzles (300a, 300b) toward the substrate (S) by the action of the pressured gas from the pressured gas supply unit (20). The controller (40) individually controls the first and second applicator (30a, 30b) so that the first applicator (30a) sprays the first liquid (F1) toward a targeted area for the first liquid (F1) on the substrate (S) and the second applicator (30b) sprays the second liquid (F2) toward a targeted area for the second liquid (F2) on the substrate (S). The present invention also relates to a method f
Resumen de: EP4599783A2
A surgical instrument comprising a jaw assembly is disclosed. The surgical instrument further comprises a motor-driven drive system configured to manipulate the jaw assembly. The surgical instrument also comprises a control system configured to control the drive system and, also, control a power supply system configured to supply electrical power to electrodes defined in the jaw assembly. In use, the surgical instrument can be used to apply mechanical energy and electrical energy to the tissue of a patient at the same time, or at different times. In certain embodiments, the user controls when the mechanical and electrical energies are applied. In some embodiments, the control system controls when the mechanical and electrical energies are applied.
Resumen de: AU2023365980A1
A melt electrowritten soft tissue scaffold, comprising: a first region having one or more sets of fibres and a second region having one or more sets of fibres; and an interface region joining the first region and the second region, the interface region being electrowritten along with the first and second regions in a continuous printing path, such that fibres in the interface region each join between a respective pair of fibres in the first and second regions.
Nº publicación: EP4599762A1 13/08/2025
Solicitante:
RELANCE SAS [FR]
Relance SAS
Resumen de: EP4599762A1
A method (10) of manufacturing a customized saddle cushion (30), such as a bicycle saddle cushion, the method comprises applying a molding paste (14) onto a saddle shell (16) to form a probe saddle (18); letting the molding paste of the probe saddle deform under a weight and motion of a rider (12) riding the bicycle during a riding session; obtaining a 2-D pressure map (22) on the geometrically stable deformed molding paste ; obtaining a 3-D saddle cushion model (21) of the geometrically stable deformed molding paste; and associating the 3-D saddle cushion model with the 2-D pressure map to obtain a 3-D saddle cushion pressure mesh (24) to be used as a reference for 3-D printing the customized saddle cushion. A density of the 3-D saddle cushion pressure mesh is correlated to the 2-D pressure map.