Resumen de: CN121370368A
本发明涉及一种基于云模式的脑出血穿刺手术区域协同方法、系统及介质,涉及医疗手术区域协同技术领域。第一服务终端响应于获取的需要实施脑出血穿刺手术患者的脑出血穿刺手术信息,生成脑出血穿刺手术协同请求并发送至第二服务终端,第二服务终端响应于收到的脑出血穿刺手术协同请求确认是否同意协同的指令,若是同意协同的指令,则向第一服务终端发送同意协同的反馈,第一服务终端响应于收到的同意协同的反馈,向第二服务终端发送确认信息;第二服务终端响应于第一服务终端的确认信息,制定脑出血穿刺手术协同方案,制作脑出血穿刺手术3D打印导板。该方案,可以在患者不需要转院的情况下,及时提供可靠性更高的脑出血穿刺手术,促进便民医疗。
Resumen de: CN121378794A
本发明涉及柔性热电材料领域,公开了一种适配复杂热源的光固化3D打印热电水凝胶及其制备方法与应用,其制备方法包括:将氯化胆碱、丙烯酸、甘油混合配制成深共晶溶剂,然后加入HEA、PEGDA和TPO形成前驱体墨水;采用前驱体墨水通过3D光固化打印机进行打印,得到深共晶凝胶并用有机溶剂进行洗涤,再在含有铁氰化钾、亚铁氰化钾、盐酸胍的混合水溶液中浸泡处理,得到适配复杂热源的光固化3D打印热电水凝胶。本发明的3D打印热电水凝胶可以实现形状定制化,在不规则热源收集、定制化可穿戴热电设备和健康监测等领域具有良好的应用前景。
Resumen de: AU2024233284A1
A method of manufacturing a patient-specific microfluidic device and a patient-specific microfluidic device are provided. The method includes obtaining three-dimensional (3D) information associated with vascular geometry in a region of interest from one or more clinical images associated with a patient, and fabricating the patient-specific microfluidic device using said 3D information. The patient-specific microfluidic device includes a flow channel having a geometry that substantially corresponds to the vascular geometry in the region of interest.
Resumen de: CN121371168A
本发明提供一种复合支架材料及其制备方法与应用,涉及复合材料技术领域,制备方法包括:将六水合氯化铁、无水乙酸钠加入乙二醇中反应,得到Fe3O4纳米颗粒;将铁氰化钾、分散介质加入盐酸溶液中溶解,再加入Fe3O4纳米颗粒反应,得到Fe3O4/PB异质结;将Fe3O4/PB异质结与左旋聚乳酸混合研磨,通过激光打印形成PLLA‑Fe3O4/PB微波抗菌复合支架材料,本发明以PLLA为载体,负载Fe3O4/PB异质结构建支架材料,通过磁‑介协同效应增强微波吸收性能,在微波照射下,借助界面极化与偶极子极化双重机制,同步实现微波热疗与微波动力,二者协同对金黄色葡萄球菌感染的骨髓炎展现出高效抗菌效果。
Resumen de: CN121371309A
本发明涉及生物医用材料与再生医学技术领域,尤其是一种基于胶原纤维‑羟基磷灰石合成的复合弹性支架及其制备方法、应用。所述的复合弹性支架由胶原蛋白与羟基磷灰石复合形成,胶原蛋白自组装形成胶原纤维网络,羟基磷灰石在胶原纤维网络中均匀分散;其制备方法如下:将酸性胶原溶液和羟基磷灰石悬浮液混合形成打印墨水,经超声与低速离心除泡后在卡波普支撑浴中进行三维打印→温控孵育形成胶原纤维网络结构→含盐缓冲液洗除支撑浴→交联处理→冷冻干燥得到多孔弹性支架。本发明表现出弹性结构特征、可观察的血液吸收及因子凝集行为,并在动物骨‑软骨缺损模型中显示出良好的修复能力及生物相容性,用于骨软骨损伤修复等组织工程领域。
Resumen de: CN121371323A
本发明公开了一种基于羟基磷灰石、氧化镁和单宁酸的多孔复合材料的制备方法,该方法以聚乙二醇二丙烯酸酯为光交联单体,二苯基(2,4,6‑三甲基苯甲酰基)氧化膦为光引发剂,通过将纳米羟基磷灰石、纳米氧化镁和单宁酸均匀分散于单体溶液中,形成光固化浆料,并在紫外光下通过光固化3D打印技术成形。其中,纳米羟基磷灰石提供骨传导性,纳米氧化镁释放镁离子以促进成骨细胞分化,单宁酸赋予材料抗菌抗炎性能;采用三周期极小曲面中的Gyroid结构作为支架结构,该结构结合各组分的功能协同作用,使制备出的复合材料骨支架同时具备高孔隙率、优良的抗压强度、显著的生物活性以及主动的抗菌抗炎能力,能够有效促进骨组织的修复与再生。
Resumen de: CN121370458A
本发明公开了一种基于3D打印的可吸收冠脉支架及其制备方法,其包括沿轴向依次排列的若干环形单元以及连接相邻环形单元的连接单元;所述环形单元为闭环的环形基体,所述环形单元沿轴向进行功能分区,具体包括:用于提供径向支撑力的第一单元,布置于钙化区;用于实现药物释放功能的第二单元,布置于长病变区;用于提供刚柔过渡以及应力缓冲的第三单元,布置于大弯曲区。本发明通过结构、材料和功能的协同分区,解决了传统支架径向支撑力与柔顺性的对立矛盾,有效降低了支架植入后的局部应力集中,提高了支架对血管的长期兼容性,并实现了药物的精准时序释放。
Resumen de: CN121375114A
本发明涉及牙托打印技术领域,具体涉及3D打印透明牙托表面后处理方法,包括以下步骤:步骤一、使用树脂清洗剂对牙托打印件进行清洗;步骤二、对清洗后的牙托打印件进行打磨处理,以去除牙托打印件表面的缺陷结构;步骤三、采用树脂在牙托打印件表面形成厚度在8‑15μm的流体树脂层;步骤四、对流体树脂层做固化处理,得到成品牙托。本申请能够制作透明度较高的牙托。本申请在牙托打印件表面形成厚度在8‑15μm的流体树脂层,并固化流体树脂层,此时,成品牙托的外表面为流体树脂层的外表面,流体树脂层可以通过填充方式使得牙托打印件表面平整,例如,流体树脂层可以填充打磨过程带来的划痕,避免这些表面缺陷影响到成品牙托的透明度。
Resumen de: CN121384121A
本发明提供了一种防数据造假的实验动物体征信息采集装置,包括信息采集模块、实验目标放置模块以及信息处理模块;所述信息采集模块包括图像采集部以及旋转部;所述旋转部带动所述图像采集部以实验目标为中心转动,实现360°采集实验目标的图像数据;所述实验目标放置模块包括托盘和压力传感器;所述压力传感器用于对实验目标进行称重;所述信息处理模块收集图像采集部以及压力传感器的信息,并反馈通过信息处理模块的显示屏显示出来。应用本技术方案可实现实验动物各种体征信息的同时采集。
Resumen de: CN121370444A
本发明涉及一种增材制造的空心股骨髁假体及其制作方法,属于人工膝关节假体技术领域。本发明的空心股骨髁假体包括股骨髁本体、堵销及可选的多孔结构。股骨髁本体设有连通的空腔,空腔可配置加强筋以增强刚性。假体内型面(如前髁面、远端截骨面等)用于与股骨远端截骨面匹配定位,外型面(如外侧髁、内侧髁)与胫骨垫和髌骨形成关节面。非骨水泥型假体设有多孔结构,其厚度为0.6‑2mm,用于骨长入生物固定;骨水泥型假体设有骨水泥凹槽用于术中固定。假体关节面采用高抛光氧化锆涂层(粗糙度低于Ra0.05),有效降低磨损。假体采用钛合金或钴铬钼合金通过激光增材制造一体成型,确保精度和强度,提升制造效率。
Resumen de: CN223819114U
本申请涉及3D打印材料领域,且公开了一种义齿3D打印材料的过筛装置,包括箱体,所述箱体的上表面固定连接有进料口,所述箱体的内侧壁滑动连接有第一过滤筛和第二过滤筛,所述第一过滤筛与所述第二过滤筛的上表面均贯穿开设有下料槽,所述箱体的侧表面卡合连接有第一接料盒、第二接料盒、第三接料盒,且所述第一接料盒位于所述第一过滤筛的下方,所述第二接料盒与所述第三接料盒均位于所述第二过滤筛的下方;本申请能够对义齿3D打印材料进行双重筛分,从而提高了义齿3D打印材料的筛分效率和均匀度,进而提高了筛分效率与筛分质量。
Resumen de: CN121371305A
本发明公开了一种采用双重冷萃冻干工艺制备的颅骨组织工程支架及其制备方法,本发明首次创造性地提出引入“双重冷萃冻干工艺”,以实现“打印‑干燥‑交联‑再干燥”的温和处理过程,在保留支架形貌精度的同时,显著增强其力学性能与结构稳定性,为3D打印骨组织工程材料的临床转化提供了全新思路与技术支撑,在临床骨修复领域具有广阔的应用前景。
Resumen de: US20260020963A1
An implant having two adjacent solid parts, a third solid part disposed between the two solid parts, and a porous part extending from the solid parts. The implant is fabricated by a process that includes first assembling the solid parts before additively manufacturing the porous part on surfaces defined by the solid parts. This process may include positioning a first fabricated component adjacent to a second fabricated component such that a side surface of the first fabricated component and a side surface of the second fabricated component form a build surface. Then additively manufacturing a structure on the build surface such that the structure extends across and is permanently fixed to both of the side surfaces of the first and the second fabricated components such that the first and the second fabricated components form part of the implant.
Resumen de: AU2025287348A1
Creating a replica of an anatomical structure. In one embodiments a method includes: accepting pictures of the anatomical structure of a subject; creating an object file that contains an initial model of an outside surface of the anatomical structure; cutting the initial model to a predetermined exterior shape circumscribing the anatomical structure to create a positive model; creating a negative model from the positive model; placing a stem tool object on an outside surface of the negative model in relationship to an orifice, thereby creating a final negative model; placing a zeroing and angling object to align the negative model to a predetermined angle; placing a base tool object by coupling the base tool object to the outside surface; and casting the replica of the anatomical structure using the negative mold. ec e c
Resumen de: US20260021487A1
A novel portable, and attachable device allows precise positioning of micro-tissues, tumor spheroids, and other biological samples during bioprinting. The device features an interchangeable connector for handling samples of various sizes and uses a manually adjustable pressure system for suction and deposition. A programmable control unit coordinates pressure and positioning based on input commands, enhancing accuracy and consistency in tissue handling. Compatible with multiple bioprinter systems and supporting both manual and automated operation, it streamlines workflows and improves user experience. This device addresses challenges in high-throughput biological positioning, critical for tissue engineering, clinical, pharmaceutical, and research applications. It supports advancements in customized medicine, biological models, and environmental monitoring, meeting the growing demand for precise biologic handling in the multi-billion-dollar bioprinting and biopsy markets. The device offers superior control over tissue biopsy positioning compared to current manual devices reliant on operator skill.
Resumen de: US20260022330A1
A composition which is a hydrogel including, in an aqueous medium: at least one hydrophilic thickening polymer, and particles of eggshell membrane, in an amount of less than 5% by weight of the total weight of the composition, wherein the particles are rod-shaped, needle-shaped or fibrous, having a specific particle size. Also described is a bioink including the composition, a method for manufacturing a 2D or 3D product using the hydrogel, a kit including the hydrogel or bioink, and to uses thereof.
Resumen de: US20260020978A1
The present invention relates to a system (1) adapted for providing a thermal and therapeutical effect to a patient (10) at a specific point of his body. The system comprises an element of contact (20a, 20b), adapted to be placed in contact to the point of body. The element of contact comprises a structural element (21) defining a tridimensionality shape. The system also comprises a thermal regulation device (50) and a regulation fluid circulating through the thermal regulation device and the element of contact. The present invention also relates to a process adapted to manufacture such a structural element.
Resumen de: US20260022324A1
A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.
Resumen de: US20260021222A1
A biological 3D printed multilayered scaffold is provided, which comprises a crosslinked native or non-modified protein containing a di-tyrosine matrix: the scaffold being configured for containing living cells introduced thereto during printing or post-printing.
Resumen de: US20260020865A1
A low-cost disposable. 3-D printed cutting guide. The cutting guide may be made with modular attachment spikes. The cutting guide may be provided in connection with a femoral trial for use in preparing a patient's bone to receive an implant.
Resumen de: US20260020643A1
A device and method for the formation of customized footwear insoles and pads is provided. The system employs computers operatively engaged to scanning components to produce individual electronic footprints of a foot of a wearer. Software operating to the tasks of employing the digital data from one or a plurality of electronic footprints, correlating to scans of the feet of a footwear user, will customize an insole or pad for positioning in the footwear to more comfortably support the foot therein.
Resumen de: US20260021632A1
The invention generally relates to microneedle devices, methods of making same, pharmaceutical compositions comprising same, and methods of treating a disease comprising administering same. Specifically, the disclosed microneedle devices comprise a plurality of biocompatible microneedles having one or more of: (i) a curved, discontinuous, undercut, and/or perforated sidewall; (ii) a sidewall comprising a breakable support; and (iii) a cross-section that is non-circular and non-polygonal. The microneedles may also be tiered. Alternatively, the microneedles may be tiered. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Resumen de: WO2024189093A1
The invention relates to a system (1) for forming a deep-drawn object, wherein the system (1) comprises: - a generative manufacturing device (2) configured to generate a three-dimensional (3D) object on a build platform (3) and - a deep-drawing device (4), characterized in that the deep-drawing device (4) comprises a receiving structure (41) configured to receive the build platform (3), particularly the build platform (3) with the 3D object (5) on the build platform (3), such that when the build platform (3) is received by the receiving structure (41), the deep-drawn object can be generated by the deep-drawing device (4) based on the 3D object (5). The invention also relates to a deep-drawing device (4) and a method for forming a deep-drawn object.
Resumen de: CN120917036A
A recombinant bacterial collagen-like protein, preferably having an amino acid sequence at least > = 60% identical to the amino acid sequence of SEQ ID NO: 1, where the amino acid sequence comprises the deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO: 1, where the recombinant collagen-like protein is functionalized with at least one thiol group. The present invention relates to a functionalized recombinant bacterial collagen-like protein, a bio-ink comprising the functionalized recombinant bacterial collagen-like protein, at least one solvent, and optionally at least one photoinitiator, a method of producing a hydrogel by cross-linking the functionalized recombinant bacterial protein or the bio-ink, and the hydrogel obtained thereby. In addition, a scaffold for tissue engineering comprising the hydrogel.
Nº publicación: EP4680622A1 21/01/2026
Solicitante:
EVONIK OPERATIONS GMBH [DE]
Evonik Operations GmbH
Resumen de: CN120882736A
A recombinant bacterial collagen-like protein, preferably having an amino acid sequence at least > = 60% identical to the amino acid sequence of SEQ ID NO: 1, where the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO: 1, where the recombinant collagen-like protein is functionalized with at least one non-terminal alkenyl group. The present invention relates to a functionalized recombinant bacterial collagen-like protein, a bio-ink comprising the functionalized recombinant bacterial collagen-like protein, at least one solvent and at least one photoinitiator, a method for producing a hydrogel by crosslinking the functionalized recombinant bacterial protein or the bio-ink and the hydrogel obtained therefrom. In addition, the scaffold for tissue engineering comprises a hydrogel.