Alerta

PREDICTION FUNNEL FOR GENERATION OF HYPO- AND HYPER-GLYCEMIC ALERTS BASED ON CONTINUOUS GLUCOSE MONITORING DATA

Resumen de: US20260102124A1

0000 Certain aspects of the present disclosure relate to methods and systems for providing decision support around glucose management for patients with diabetes. Time-varying inputs including blood glucose, meal intake information, and amount of infused insulin are processed using a machine learning model to obtain predicted glucose levels for a plurality of prediction horizons and uncertainties for the predictions. A confidence interval is generated for each prediction and the confidence intervals are compared to hypo- and hyperglycemic thresholds. If a confidence interval is entirely below or entirely above the hypo- and hyperglycemic thresholds, respectively, then a decision support output is provided.

ARTIFICIAL-INTELLIGENCE TECHNIQUES FOR NEUROTOXICITY DETECTION

Resumen de: US20260106042A1

Detecting neurotoxicity associated abnormalities due to certain medication therapies can be significant for identifying various neurological disorders. The present disclosure relates to detection of neurotoxicity related disorders by leveraging an interface including one or more sets of queries and a set of components to receive a set of responses corresponding to the sets of queries. The techniques, as disclosed herein, may use one or more attributes of the set of responses including consistency, complexity, grammar and spelling correctness, and time taken during the responses. The disclosed technique may preprocess the responses, extract features and generate one or more metrics corresponding to the one or more attributes of the one or more responses provided by the subject during a session with the interface. The generated metrics over a baseline session and subsequent sessions may be used to determine trends in the metrics which may be used to estimate the extent of neurotoxicity developed by a subject and may trigger an alert about a potential neurotoxicity or a preventative measure to reduce a likelihood of further neurotoxicity.

NOVEL 3D PRINTING SELF-STABILIZING CERVICAL INTERBODY FUSION CAGE

Resumen de: US20260102258A1

0000 A novel 3D (three-dimensional) printing self-stabilizing cervical interbody fusion cage is provided, including a fusion cage body, circular-arc notches arranged at four corners of a front side surface of the fusion cage body, and threaded openings are formed in interiors of the circular arc notches and screws are correspondingly mounted in the threaded openings. An inner wall of the fusion cage body is of a circular arc structure, and a reserved circular opening is formed in the middle position of the front side surface. Each of the circular arc notches is positioned to form an angle of 45° with a horizontal plane of each of the four corners of the fusion cage body. Screw are self-tapping screws with threads, and the threads of the screws are in fit with threads of the inner walls of the circular arc notches.

DESIGNING PATIENT-SPECIFIC SURGICAL ITEMS

Resumen de: WO2026078555A1

A method of designing a patient-specific surgical item comprising: obtaining, by one or more processors, a 3-dimensional (3D) item model representing at least a surface of a patient-specific surgical item that is shaped to conform to one or more anatomical structures of a patient; determining, by the one or more processors, a size of a 3D primitive shape and a position of the 3D primitive shape such that the 3D primitive shape is collocated with a protrusion artifact of the 3D item model; modifying, by the one or more processors, the 3D item model to exclude portions of the 3D item model collocated with the 3D primitive shape; and generating, by the one or more processors, output data based on the modified 3D item model.

MULTI-FUNCTIONAL POLYMERIZABLE COMPOUNDS AND METHODS OF PRODUCING AND USING THE SAME

Resumen de: WO2026080633A1

The present disclosure provides synthesizing multi-functional polymerizable compounds and methods for the synthesizing the same. The methods include reacting a compound of Formula (Ia) with an epoxide of Formula (Ib) with quantitative conversion, requiring only an aqueous work-up for purification. Further provided herein are methods of producing polymerizable composition, methods of forming an article by additive manufacturing processes (e.g., via 3D printing), such as orthodontic appliances with increased stain resistance.

3D STRUCTURE-FUNCTIONAL DESIGN OF BIOMASS-DERIVED SOLAR PHOTOCATALYST FOR ANTIMICROBIAL EFFICACY AND CHEMICAL DEGRADATION AT AMBIENT CONDITIONS

Resumen de: US20260102758A1

The subject invention pertains a stable, three-dimensional (3D) photocatalyst composition comprising TiO2 doped with carbon derived from lignin. The photocatalyst composition has a stable, hollow, spherical or spheroid nanoparticle structure, which improves photodegradation under visible light irradiation over unmodified TiO2 photocatalysts. The subject invention also provides methods of preparing the photocatalyst, as well as methods using the photocatalyst to remediate contaminants such as pharmaceuticals, pathogens and persistent organic pollutants.

PATHOGEN MONITORING SYSTEM AND METHOD

Resumen de: WO2026080101A2

The portable sensor system (100) includes a containment portion (102) and a sensor portion (104). The containment portion (102) may include a shipping container such as a jar. The sensor portion (104) may include a cap (106) that may be selectively coupled with the containment portion (102). The cap (106) may include a battery module (108), a processing module (110), and a sensor module (112). In a specific example, the portable sensor system (100) may be provided in four layers (a battery module layer (108), a processing module layer (110), a sensor module layer (112), and a coupling mechanism layer (114). The coupling mechanism layer (114) may be configured to selectively lock the cap (106) to the containment portion (102). In a more specific example, one or more of the layers (108, 110, 112, 114) may be 3D printed. The portable sensor system (100) may be utilized as a smart-monitoring device for the presence of a pathogenic bacteria in the shipping container.

INJECTION MONITORING MODULE

Resumen de: WO2026078408A1

An injection monitoring module comprises an indicator of rotational movement about a lengthwise axis; a sensor configured to contactlessly detect rotational movement of the indicator about the lengthwise axis; a processor connected to the sensor, wherein the processor is configured to receive and process signals from the sensor; wherein, in a first axial position of the injection monitoring module, the indicator of rotational movement is prevented from rotational movement about the lengthwise axis; and wherein, in a second axial position of the injection monitoring module, distinct from the first axial position, the indicator is free to corotate about the lengthwise axis along with a dose dispensing component of an injection pen system, onto which, or into which, the injection monitoring module has been mounted.

Systems and Methods for Determining the Orientation of Motion-Sensing Devices During Physical Activity

Resumen de: US20260102656A1

0000 A computer-implemented method for providing real-time performance feedback includes receiving uncalibrated time-series motion data generated by one or more motion sensors coupled directly or indirectly to an athlete while performing a downhill snow sport, the motion sensor(s) having an unknown rotational orientation relative to the athlete; determining an estimated rotational offset of the motion sensor(s) relative to a body-segment coordinate frame of the athlete, the rotational offset determined using a calibration model; transforming, by the one or more processors, the uncalibrated time-series motion data to calibrated time-series motion data according to the estimated rotational offset, the calibrated time-series motion data aligned with the body-segment coordinate frame; and processing the calibrated time-series data, with the one or more processors, to determine one or more metrics for the athlete.

DEEP REINFORCEMENT LEARNING BASED ROBUST NEUROVASCULAR MAPPING

Resumen de: US20260105597A1

Systems and methods for generating a patient-specific vascular tree are provided. 1) one or more medical images of a patient and 2) a vascular tree template comprising a plurality of points are received. The plurality of points of the vascular tree template are iteratively adjusted based on the one or more medical images using one or more AI (artificial intelligence) agents to generate a patient-specific vascular tree for the patient. The patient-specific vascular tree is output.

SYSTEMS, METHODS, AND DEVICES FOR TARGET CONTROLLED INFUSION

Resumen de: US20260102564A1

0000 A system for programming infusion devices for target controlled infusion is disclosed. The system includes a docking station and one or more processors configured to determine a first infusion device docked with a docking station and accept user input of one or more of patient-specific parameters, drug-related parameters, and a desired target concentration of a therapeutic agent in a workflow on the first infusion device for programming a target controlled infusion (TCI) therapy. After receiving a particular set of parameters, the set of parameters can be copied to the second infusion device to pre-complete and bypass a number of workflow steps of a second workflow of another infusion device. When the second workflow is accessed, the number of workflow steps of the second graphical interface workflow are pre-completed and bypassed.

REGISTRATION AND TRACKING BY 3D SCANNING THE TOPOLOGY OF ANATOMIC STRUCTURES

Resumen de: WO2026080793A1

A system and method for registering and tracking anatomical structures during surgical procedures by leveraging continuously updated 3D topological data of objects within the surgical field. Registration allows different datasets such as preoperative CT scans and intraoperative 3D scans to be aligned, combined, and transformed into a common coordinate space, enabling more precise surgical planning and execution. Tracking involves continuously registering these datasets over time, monitoring changes in position or orientation, and keeping objects aligned within the common coordinate space, updating the spatial alignment of registered objects multiple times per second, which allows for dynamic monitoring of anatomical structures and surgical tools as they move throughout the procedure. Unlike traditional systems that rely on physical optical markers (OMs) and optical tracker constellations (OTCs), the system and method disclosed herein utilizes the data captured by a 3D scanner to perform Continuous Anatomic Auto Tracking (CAAT).

METAL OXIDE BIOLOGICAL IONOMER AND METHODS

Resumen de: US20260102509A1

A nanoparticle compound comprising buckminsterfullerene C60 bonded to ester functional groups of pyruvic, citric, and hyaluronic acids, with oxygen-bridged components selected from vanadium, gallium, and bismuth is provided. At least one component enables quantum-mechanical spin-wave activation. Ultrasonic irradiation activates the compound, inducing electrical induction for tissue healing and cell growth. The compound integrates with native and 3D-printed tissues, enhancing their properties through interpenetrating networks. It exhibits anti-inflammatory, antioxidant, and antibacterial effects, reinforces connective tissue, and modulates stem cell growth. The compound treats arthritis, enhances gut health and barrier function, supports bone health, improves voice quality, counters cancer cell proliferation, and mitigates osteoporosis. The gallium component creates an alkaline environment for calcium deposition, while vanadium enhances chondrogenic differentiation. Administration methods include topical application, oral ingestion, injection, and infusion through bandages or sutures. The compound serves as an adjuvant for analgesics, enhancing their delivery and efficacy.

SYSTEMS AND METHODS FOR BIOPRINTING CORNEAL STROMA EQUIVALENTS

Resumen de: WO2026078545A1

Synthetic corneal stroma are created though a bioprinting process. The bioprinting process utilizes Digital Light Processing (DLP) in the formation of the corneal stroma. A hydrogel is formed to serve as the basis for the DLP printing. The DLP printing process provides control exposure of the hydrogel to UV light. The bioprinting through the DLP printing process forms a synthetic corneal stroma.

3D SCANNING METHOD, SYSTEM AND APPARATUS FOR DENTAL APPLICATIONS

Resumen de: US20260102230A1

A method and device for aligning face scans with intraoral scans in dentistry applications. Digital intraoral scans capture the upper and lower arches and a bite registration. An Anterior Extension Device is affixed in the patient's mouth. A working scan of the upper arch scan is trimmed to remove the areas covered by the Anterior Extension Device. A rigid reference link extends between the Anterior Extension Device and base of the patient's nose. The working scan is rescanned to include the Anterior Extension Device and rigid reference link and patient's nose. A facial scan is taken while the patient is smiling. The rescanned working scan is aligned and merged with the facial scan on the basis of at least three points of reference on the patient's nose. A prosthetic device is designed using in combination the intraoral scans aligned with the facial scan.

3D BIOPRINTING PLATFORM FOR GENERATION OF FUNCTIONAL PRIMARY AND HPSC-DERIVED ORGANOIDS IN HYDROGEL CONSTRUCTS

Resumen de: WO2026080718A1

The disclosed concept includes the preparation and use of biocompatible bioinks, as well as techniques and methods therein for bioprinting, preparing and 3D printing primary cells and patient-specific cells and forming functional soft tissue in a three-dimensional construct form that incorporates the cells and mimics native tissues. The biocompatible bioinks include alginate, methylcellulose, and primary or iPSC-derived cells in the form of single cells or aggregates. The bioprinted 3D construct includes one or more of the iPSC organoids, human islets, as well as TEPCs.

APPARATUS AND METHOD OF DETERMINING A CARDIAC IMPLANT SIZE AND METHODS AND SYSTEMS FOR TRANSESOPHAGEAL ECHOCARDIOGRAM GUIDED IMPLANTATION OF LEFT ATRIAL APPENDAGE CLOSURE DEVICE

Resumen de: WO2026080652A2

Apparatus and methods of determining a cardiac implant size and methods and system for transesophageal echocardiogram guided implantation of left atrial appendage closure device. The apparatus includes an ultrasonic imaging device, at least a processor, and a memory communicatively connected to the at least a processor, wherein the memory contains instructions configuring the at least a processor to using the ultrasonic imaging device collect a plurality of ultrasonic images using a 3D cardiac model generation machine learning model trained on a training dataset including example ultrasonic images correlated with example 3D cardiac models. The processor is further configured to generate a 3D cardiac model based on the plurality of ultrasonic images, generate at least a cardiac measurement based on the 3D cardiac model, determine a cardiac implant size based on the at least a cardiac measurement, and using a display, display to a user the cardiac implant size.

SYSTEM AND METHODS FOR LOCATING DRIVERS OF ATRIAL FIBRILLATION

Resumen de: US20260102102A1

The present disclosure applies to methods of cardiac ablation that use an algorithm to determine where in the heart a driver of atrial fibrillation is located. Catheters with multi-electrode arrays are used to measure electrograms from cardiac signals wherein abnormal signals are identified as electrogram deflections with characteristic shapes. The electrogram deflections are compared to each other in pairs to determine which came first in time in order to determine the net direction of propagation of a fibrillatory wave. The signal that came first is assigned a positive point value so that once the plurality of electrograms have been compared, the signal with the highest point value can be identified as a driver of fibrillation. The data can be displayed graphically as a map of atrial fibrillation drivers on a 3D representation of a heart, allowing surgeons to quickly and easily identify where on the heart the driver is.

HYDROGEL-LIKE BIOMIMETIC MATERIAL COMPRISING REGIONALLY DISTRIBUTED MICROENVIRONMENTS, METHOD OF MANUFACTURE, AND USES THEREOF IN RESEARCH, INDUSTRIAL, AND THERAPEUTIC APPLICATIONS

Resumen de: WO2026078632A1

Hydrogel-like biomimetic material comprising regionally distributed microenvironments, method of manufacture, and uses thereof in research, industrial, and therapeutic applications The hydrogel-like biomimetic material (100) has a three-dimensional distribution of biomimetic microenvironments (110), wherein each biomimetic microenvironment (110) comprises (a) a polymeric network (A) that simultaneously provides structural support and functional activity; and (b) a water-based suspension (B), wherein the water-based suspension (B) is sustained by the polymeric network (A).

TREATMENT PLANNING FOR TUMOR TREATING FIELDS

Resumen de: US20260102612A1

A method for generating a transducer layout for delivering tumor treating fields includes storing medical images of a subject, identifying one of the medical images as an anchor medical image, and registering computed tomography medical images with magnetic resonance imaging medical images. The method further includes segmenting abnormal tissue in the medical images from other tissue types and defining a region of interest (ROI) in the medical images. The method further includes creating a 3D model of the subject. The method further includes generating a plurality of transducer layouts for application of tumor treating fields to the subject, selecting at least two of the transducer layouts as recommended transducer layouts, presenting the recommended transducer layouts, receiving a user selection of at least one recommended transducer layout, and providing a report for the selected recommended transducer layout(s).

METHODS AND SYSTEMS FOR VAGINAL THERAPEUTIC DEVICE FITTING

Resumen de: EP4725409A2

0001 Pelvic organ prolapse (POP) and urinary incontinence (UI) are common, often distressing conditions, where, at present, physical non-surgical devices are fitted by best guess or trial-and-error with devices offered in a range of standard designs and sizes. However, each user is unique and accordingly methods, systems and devices providing a personal pelvic health characterization and provisioning approach are outlined that factor user specific anatomy and physiology, user lifestyle, user experiences and automated assessments into provisioning custom vaginal therapeutic devices. Further, user specific anatomy and physiology should be obtained in a reproducible manner with devices and systems that remove measurement artifacts, errors, bias etc. whilst providing the patient with an improved experience and the medical personnel with ergonomic, efficient, and easy to use systems exploiting combinations of dedicated multi-patient measurement equipment with user specific consumable items for cleanliness etc.

PATIENT SPECIFIC INSTRUMENTATION AUTOMATION PLATFORM

Resumen de: WO2024257100A2

The present invention, in some embodiments thereof, relates to a surgical guiding joint integration group (JIG) and, more particularly, but not exclusively, to a surgical guiding JIG for varus de rotation osteotomy (VDRO) procedure.

METHOD FOR PRODUCING A REMOVABLE DENTAL PROSTHESIS, AND REMOVABLE DENTAL PROSTHESIS PRODUCED ACCORDING TO THE METHOD

Resumen de: WO2024251724A1

The invention relates to a method for producing a first connection element of a removable dental prosthesis, said connection element being suitable for a sliding connection between a first fit surface of the first connection element and a second fit surface of a second connection element of the removable dental prosthesis. The invention is characterized in that the first connection element is produced by connecting a stability-granting material and a ductile material which forms the first fit surface in an additive multi-material manufacturing method.

CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS

Resumen de: WO2024254134A2

The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having at least one coating layer provide drug storage and drug release tor the treatment of various diseases, disorders, or conditions, One aspect of the present invention includes a packaged medical device including a medicament. Another aspect of the present invention includes a drug delivery contact lens. A farther aspect of the present invention includes a. method of making a drug delivery contact lens. An additional aspect of the present invention includes a method of using a drug delivery contact lens. A further aspect of the present invention includes a medical device including bimatoprost and N-vinylpyrrolidone.

BIO-PRINTED SKIN MODEL, RELATED THREE-DIMENSIONAL PRINTING PROCESS AND DIRECT PERFUSION DEVICE PROVIDED WITH SAID MODEL

Nº publicación: EP4724558A1 15/04/2026

Solicitante:

BIO SYSTEM LAB S R L [IT]

Resumen de: WO2024252292A1

The bio-printed skin model (1) comprises: - at least one dermal layer (2) comprising at least one polymer matrix and a mixture of fibroblasts and endothelial cells and configured to simulate a human dermal tissue; - at least one epidermal layer (3) comprising at least one mixture of keratinocytes and configured to simulate a human epidermal tissue; wherein the dermal layer (2) comprises at least one inner duct (4) formed by fibroblasts and endothelial cells, configured to simulate a vascular channel of human skin and provided with at least two end stretches communicating with the outside and connectable to a system for active perfusion of substances.